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<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0I4T7</accession>
    <name>R0I4T7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_51621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="KB908881">
        <property type="protein sequence ID" value="EOA80665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031705.1">
        <property type="nucleotide sequence ID" value="XM_008033514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I4T7"/>
    <dbReference type="STRING" id="671987.R0I4T7"/>
    <dbReference type="GeneID" id="19405184"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1820503_0_0_1"/>
    <dbReference type="OrthoDB" id="3925403at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA80665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="142" mass="15468" checksum="87DD0E12B056F5E5" modified="2013-06-26" version="1" fragment="single">KVLGKQDVGFRLVEQEQALHAVLEKQTPLIVVLPTGGGKSLLFTLPACVEETGVTVVVVPYRALIEDLVGRIQRCGVDCIEWKYGENDPASVVVVSADVAGDIKSGGNFLGMLVRHATYVRASTVRPNARYFVSWCQRGKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6G1</accession>
    <name>R0I6G1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_100448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031628.1">
        <property type="nucleotide sequence ID" value="XM_008033437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I6G1"/>
    <dbReference type="STRING" id="671987.R0I6G1"/>
    <dbReference type="GeneID" id="19394794"/>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025883_0_0_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA81091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="505" mass="57306" checksum="26B945DD5022AB62" modified="2013-06-26" version="1">MEHHRDIVEAVRSRVQHFYATKAGFRIYHGSTNSTRHADFDRNAIVDVSILDQVISINHDTKTALVEPNVPMDVLVQETMKAGLLPPVVMEFPGITVGGGFVGTAGESSSFKYGFFDRTVLSAEVVLADGTLVTASASQNTDLFEGLRGSFGTLGVLTMVEMQLIPLRQMVEVTYHPTFSFENATGTMKYHVSDARNDYIDGIIFSKGTGVVVTGRLIDTPISTSSRLPVQRFSRPWDEWFWIHARTASSRGIVTKELVPIQDYLFRYDRGAFWMCMYAYRYFMVPFTWMTRFLSDYFMHTRIMYHALHTSGHTDRYIIHDIAFPANNATPFLEYADEAFSLYPIWLCPLRRDGRSSMGHAKLFSGLVGGKPVDGCEGEGISVGLWGPYPSNEGEFVRANRDIEAKMRELGGLKWLYSRVFYSEDEWWQVYDKHGYDELRRKYHATSLPSIWDKVKDRGRRQDFGTGVKGLLKRLVKSNAFLSGLYGIYKAVKGGDYMLKKQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8W2</accession>
    <name>R0I8W2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_165494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030317.1">
        <property type="nucleotide sequence ID" value="XM_008032126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8W2"/>
    <dbReference type="STRING" id="671987.R0I8W2"/>
    <dbReference type="GeneID" id="19399491"/>
    <dbReference type="eggNOG" id="KOG2274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008920_1_1_1"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA81955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113521" checksum="1B379550E8A2BA0B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0I921</accession>
    <name>R0I921_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_97377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030347.1">
        <property type="nucleotide sequence ID" value="XM_008032156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I921"/>
    <dbReference type="STRING" id="671987.R0I921"/>
    <dbReference type="GeneID" id="19406302"/>
    <dbReference type="eggNOG" id="KOG3108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051033_0_1_1"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="7">
        <location>
            <begin position="64"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="8">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA82000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="261" mass="27504" checksum="6732F67D02D8A831" modified="2013-06-26" version="1" fragment="single">GAGGGAGGGGFIPGEGGSTQSPGGRRDHAQDSLRPVTIKQILDAQGEAGSNDTFKIDGTAISQITLVGQIRNISNQTTNTTYRLDDGTGSIEVKQWVDTDAAEQTNPTKAKLVEGAYCRAWGKLKSFNDRKSVGATVIRPIEDMNEISFHMLEATAVHLYFTRGPPNQAGGAATNGAVQQQATAGGNFGSYDLAGYSQVAKRVFQFLRETEQSNEGLNQYEIAAKLGIDAADVAKAGDDLLSGGLIYTTVDDQTWAILEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0I978</accession>
    <name>R0I978_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_165484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030304.1">
        <property type="nucleotide sequence ID" value="XM_008032113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I978"/>
    <dbReference type="STRING" id="671987.R0I978"/>
    <dbReference type="GeneID" id="19399484"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="9">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="10">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA81941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="216" mass="24155" checksum="9AA0D7D55F1BA582" modified="2013-06-26" version="1">MYGEAANKLVQNAKRTLALPHLPPYATELTRSIVREVRDLDKDVSSILAPYGGSFNPSASPETACALLVNHLCMRRNKRCLLAYHRVRSDKLEEYCWEGVDVLEQQGSRDHSGEAGRSALGAGGGREESSLSPEEEEYVRQYSDLLAAYKGQWTDIDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGSITLTKNSQFYVRQGDVERLIAQGYLQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9A3</accession>
    <name>R0I9A3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_181310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030392.1">
        <property type="nucleotide sequence ID" value="XM_008032201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9A3"/>
    <dbReference type="STRING" id="671987.R0I9A3"/>
    <dbReference type="GeneID" id="19401838"/>
    <dbReference type="eggNOG" id="KOG2580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020932_2_0_1"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="391"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA82065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="551" mass="61368" checksum="0EC4F07DA3A99C50" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9U2</accession>
    <name>R0I9U2_EXST2</name>
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        <recommendedName>
            <fullName evidence="18">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="18">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Phospholipid methyltransferase</fullName>
            <shortName evidence="18">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_165674</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 18">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 18">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA82235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_008030504.1">
        <property type="nucleotide sequence ID" value="XM_008032313.1"/>
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    <dbReference type="STRING" id="671987.R0I9U2"/>
    <dbReference type="GeneID" id="19399545"/>
    <dbReference type="eggNOG" id="KOG4142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086119_0_0_1"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="18">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EOA82235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="200" mass="22047" checksum="87AFB36351300452" modified="2013-06-26" version="1">MSEYIDFGKRSLWISAASIVFNPTFWNIAAQQEYHNKVITKLFGGNSRLGCYALAVAIFSLGIFRDALYKDALGDQPVHPALLSPVVKYSVIPLFLTGNVLVLSSMWALGVTGTYLGDYFGILMDEPVTSFPFNVSSSPMYHGSTMSFLATALWYGKPAGILLSGLVSVAYSIACKWEDPFTAMIYQKREEQRAQGKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0IA85</accession>
    <name>R0IA85_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_165676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030508.1">
        <property type="nucleotide sequence ID" value="XM_008032317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IA85"/>
    <dbReference type="SMR" id="R0IA85"/>
    <dbReference type="STRING" id="671987.R0IA85"/>
    <dbReference type="GeneID" id="19399547"/>
    <dbReference type="eggNOG" id="ENOG502SA5X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048021_3_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="259"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="259"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="320" mass="35071" checksum="8B3029E59B5AEB07" modified="2013-06-26" version="1">MLAGALCRLAADVPRRSPHDMPQLARHLGRTLLALSAREAPAARALPCALYSHRSYATTATATRATKPTATVKKAVKAAAAEKPPPKKAAAPAKKTTAQKPAAKTTKKAEAKKPAAKKARPGRKRKVLTDEEKEKIKIRDLRAKALKEPVTQRALSAYNAFIAEAAVGKVDEGAKQATKIADLSRQFKELTPAQLEHYNHLAQQLNAANKAKLDAWINSHTPEEIRVANRARALLRKKLMGKQKSAPAYTSKLHDDRQVKTVPSAYIFFFTARHASGDFKNIKAQDASKLIGNEWKALSDAEKKKYEEERQAAKQRVNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAP2</accession>
    <name>R0IAP2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_43457</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029494.1">
        <property type="nucleotide sequence ID" value="XM_008031303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAP2"/>
    <dbReference type="STRING" id="671987.R0IAP2"/>
    <dbReference type="GeneID" id="19404853"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027519_0_0_1"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="136"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="424" mass="46239" checksum="96959395BCB90EE1" modified="2013-06-26" version="1">MMAPGGNSTKGPTPISVLQRMTCRDPGVRGRIWVAKVRFGVPGGVGVLKGESGEREEEGEDDVRNTVFNAIQEMREPYDPYDDIHWDHKIGSHPLTAEWTGYRSAADANTPEPADVSEAQKYECLMQETTSKITTLYFHGGAMYLLDPATTRATTGRLARETGGRVFSVRYRLAPQNAFPAALLDAFTAYLTLLAPPAGSLHEAVAASEIVFAGDSAGGTCCTALLQLLLHLHRQAPAGQVPRVRFHGKNVSIPLPAGVALASPWLDITRGLPSIESAVAFDYLPAPSALATHEYPVEEGVWPAEPPRADLYCEAGALLHPLVSPLAAKSWTGSPPLFFSVGHEMLRDEDAVLAQRAVAQNVPVVWREFEAMPHCFAMLLEGIAETQVHWEEFASFCRHVVQDRDSVVTNETSNTHSNHKKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAQ6</accession>
    <name>R0IAQ6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_22497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029342.1">
        <property type="nucleotide sequence ID" value="XM_008031151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAQ6"/>
    <dbReference type="GeneID" id="19402562"/>
    <dbReference type="HOGENOM" id="CLU_1176039_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="236" mass="26834" checksum="8F906C10E8B72093" modified="2013-06-26" version="1">MSSPFVFDTDDIDLRLKSTHLQENWDTTMASEDGKTAVNDEATDSPKPSNSPGHQISTEPQRLSPSVEEEDTNDEEEEEPDTSLQPRNKPSPSSSLSPPPPSSSPASQTPTKPVRKLTLNLKFSAPKTPLNMTNPLFMPRARNHVWQAAWEKHIKMRVTPLRGKRGVMDGKWKRGEVKGRNVWDLLQSSEMELDGDEDEIERWIGRRSGEEEEEESDAEKWFRKKLWGAGRWASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0IB17</accession>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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    <sequence length="345" mass="38473" checksum="7C9F5128DAB70695" modified="2013-06-26" version="1">MYHDSRHSCVEITPMKMSAERLLAYSITHRFVSRLGPLQIVKSFGKDDWAIIVALISFGLGNRLEVLEENVTSYRRLLLARLLHQVFVVLAIGLVKISICMFLLRLVTKKLYVWFLWGMVAFMSAFTIASVLTIVLQCDSISAAWDYSLRLPPMEVGHSKCYSLNTFKHIGLFNGGMRIMKHTPPNLVADDTVIHILTDVLLALLPTLLIWRLHMVRRVRLSLIAVLSIGILAAIAGIIRQVSAGPLDEYDAYSIWNLVELHLGIVAASLPALKRIFIKVFETIGSAASAARTAKYDVSNSIVLPSYGNATAVRGAWKLEDTSQIDVLCARDNIRVTREVQVDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0IF73</accession>
    <name>R0IF73_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_155255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028376.1">
        <property type="nucleotide sequence ID" value="XM_008030185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IF73"/>
    <dbReference type="GeneID" id="19397496"/>
    <dbReference type="HOGENOM" id="CLU_2759418_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="70" mass="7639" checksum="BD0B9E201C25B673" modified="2013-06-26" version="1">MACFSTQHRCDSSLPQVTDVAAIKGPHKSPRSLILSRSKYGAFHATLVPPMQSAEKETWDHLTPNTDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0IM92</accession>
    <name>R0IM92_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_169254</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026138.1">
        <property type="nucleotide sequence ID" value="XM_008027947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IM92"/>
    <dbReference type="STRING" id="671987.R0IM92"/>
    <dbReference type="GeneID" id="19400842"/>
    <dbReference type="eggNOG" id="KOG2916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA86120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="311" mass="35171" checksum="0BD75C23F1C2F5A2" modified="2013-06-26" version="1">MSLTNCRFYEEKYPEVESFVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKDKGYIDLSKRRVSPEDIVKCEERYNKSKMVHSIMRHVAEKTQTPIEEIYQTIGWPLNKKYGHSIDAFKLSITNPEVWNDVTFPNEVVKEELQSYIGKRLTPQPTKVRSDIEVTCFGYEGIDAVKSALRCAEAKNTPENQVKVKLVSPPLYVLTSQCLDKNAGIACLEQAILDIKENISNAGGDCQVKMAPKAVTENDDAELAALMEKRERENQEVSGDEDESTSDEGGVAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IMV0</accession>
    <name>R0IMV0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_150854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025975.1">
        <property type="nucleotide sequence ID" value="XM_008027784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IMV0"/>
    <dbReference type="STRING" id="671987.R0IMV0"/>
    <dbReference type="GeneID" id="19397087"/>
    <dbReference type="eggNOG" id="ENOG502SYFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_0_1"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="134" mass="14635" checksum="72B6E2ED4200630F" modified="2013-06-26" version="1">MPTAPAADAPAATYNASCHCGAFAYSVTISPPLDSPSSTVTECNCSICTRNSYLLVYVPNERVVFSKGRIEQFCSYSFATKKMDHYFCGACGSACMVRSRFEHFFPGMTAVNVRMLHHVDVKRLNTKAADGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0IN25</accession>
    <name>R0IN25_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_169283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026174.1">
        <property type="nucleotide sequence ID" value="XM_008027983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IN25"/>
    <dbReference type="GeneID" id="19400854"/>
    <dbReference type="HOGENOM" id="CLU_2098344_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="116" mass="12652" checksum="92D2A991737E2BB4" modified="2013-06-26" version="1">MSVSSLKYSGAHPQWSSSRCTNSSPYVSSKNSSPARTGHEAEYRGATIDPHASHSDDRMSFGSRAKSGPISITRSQISSWRLPPKLPCHTGITASWLFPIPTSSEAIRFEASIWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0INT3</accession>
    <name>R0INT3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_161307</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026037.1">
        <property type="nucleotide sequence ID" value="XM_008027846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0INT3"/>
    <dbReference type="STRING" id="671987.R0INT3"/>
    <dbReference type="GeneID" id="19398141"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010480_1_0_1"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015275">
        <property type="term" value="F:stretch-activated, monoatomic cation-selective, calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000345">
        <property type="entry name" value="Mechanosensitive ion channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.60:FF:000006">
        <property type="entry name" value="Predicted mechanosensitive ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <location>
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        <location>
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        <ligand>
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        <ligand>
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        <location>
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        <ligand>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024772.1">
        <property type="nucleotide sequence ID" value="XM_008026581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IS96"/>
    <dbReference type="STRING" id="671987.R0IS96"/>
    <dbReference type="GeneID" id="19401519"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF1">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="147"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA87536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="464" mass="50632" checksum="1AEC883B70857A23" modified="2013-06-26" version="1">MGSKSPEDHRRGPNGSPEHAAIAVVNPPKSAVASGLLQGMLEGQGENGDDDDDDDDDEENVGADVKTTDGAKKKRKRNKKKNKKGPATQQSFPPRVPLTQLFDGRPYPEGQIVEYPAKNDNLQRTTAEEVRHQAALSNMDDEFLSDYRKAAEIHRQVRHYAQKLAKPGVSMTYLAEEIDESVRALTGHHGLSPGDSLKAGLAFPTGLCLNHIGAHWTPNAGAKEVFLQHDDVLKVDFGVHVNGRIVDSAFTIAANPVYDNLLAAVKAATNTGLKEAGIDARIDHISASIQEVMESHEITLAGKTLPIKAVRNITGHNILRYRIHGSKQVPFVKTKTTQRMEEGDVFAIETFGTTGTAVLRDDIGVYGYARNEHANTAGLHHASAHALLRTIDQNFGTLVFARRQLERIPGVKSYHLGMRSLVNSGIVDAYAPLVDVPGSYVAQFEHTVLLRPNCKEVVSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISS3</accession>
    <name>R0ISS3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_185141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908573">
        <property type="protein sequence ID" value="EOA87666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024704.1">
        <property type="nucleotide sequence ID" value="XM_008026513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ISS3"/>
    <dbReference type="STRING" id="671987.R0ISS3"/>
    <dbReference type="GeneID" id="19402094"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026724_0_0_1"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="335" mass="37042" checksum="157D76B39C96B658" modified="2013-06-26" version="1">MKSLRSKDRLQEPVLTHRYLASRFFKDKSSPEKKAAVNDKLDVEYNAGIQGAITKKPSRFFGRKYDKYDKLNKPLPALPLNSSSSTILAPVENKTAAREHNDDFDNLSDYDDDNDLESPQCPSTAKRTRTGGLETAKLKSYSSLATLRSKSSRIFSGKMTTSSHSPPPPPLPQIPVDIASIYAQRPIATASSTYRSTHSARSLFANPHDRSISISRPQLRAQVSSPPVLERTSTIPYDKRPGPAPVRPVRPASLDDETAAFMRETNTRMVLPRRTRDTSSTATTSTLRSHSSSIEARLGIPCGHGTVGWWSGVEYGVGVCCMLYAVWNVMWRAGL</sequence>
</entry>
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        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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    </dbReference>
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        <location>
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            <end position="156"/>
        </location>
    </feature>
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        <location>
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            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="172" mass="18691" checksum="7CF4D9314FB07600" modified="2013-06-26" version="1">MAMQRPVTPSAAYHSVPQVDDPAHLSRGYGSAPHSHAAINDFSPSSPAAHHDRERRGRFDEDFDAPTRGSSVVDGDMRPRSESRSSTLNQGPAPSRSGTLKKKGSIKRSASMKRSASRKSLHAGSIRGVPVDDQDGGYDREDSVFYTPVPTKGSPTDILAERFQGTWMQVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_26062</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="3799586at2759"/>
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        <location>
            <begin position="154"/>
            <end position="173"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA89735.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="255" mass="27657" checksum="AC0F41EFA6652E9C" modified="2013-06-26" version="1">MSPPIFAGVTERSQKFYNGTYTWDSDGFTDDTGVHRYFDCYDPVARAPTPLPPMGLAGDDKGEVQDQSGTLSVNHDKFGATKSFTFALDGGSKRGTVTVQCHELFRDRADREHLIGKMEGVLVASKAHNVDLTLEECYQLCGIPYSDTRVGKALPENITPPSSPSNNKCTESKLWSPSSLSELSSCPSDLSEWDVAQAPKNQATATKIAPQELPLKVEKPKPKPGTRGIAQKVKNGVKKPAAKLATYAHTPQFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYD1</accession>
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            <fullName evidence="2">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_167419</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022546.1">
        <property type="nucleotide sequence ID" value="XM_008024355.1"/>
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    <dbReference type="AlphaFoldDB" id="R0IYD1"/>
    <dbReference type="STRING" id="671987.R0IYD1"/>
    <dbReference type="GeneID" id="19400163"/>
    <dbReference type="eggNOG" id="KOG3715">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_030576_0_0_1"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="2">
        <location>
            <begin position="201"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="433" mass="46666" checksum="C7548BECA5D88AFC" modified="2013-06-26" version="1">MDFTISLAHFCEVHGPTSIICTQASTSPCGSCNPCVTPPSDEPHDACSFNHLYDQPTSLKLNPPRPPHVTSPFDSPPTSPHSPSHNPYFPSLSSSSSASSFGGRRPSSTLDSDSDVCENCQMVVPQKYSDKIPNGAPGSPTKDGRGRNGSPVLRSSQSYPVRRPVSRDDVSSTDSSDVSDTEQSASFQSATSSLYPDSIPTSPLMGSRAVHTHTLNYISTSQPQSPSTYSLLRRTCIRTLSTEVLPLSKPSGPIMFGDSVAGYTIAYVFRLQDPRSRGAKRTYALIAMAGRDCRRATKAMVKITEAFESIANRIISLADRVLERESAASQGLSRPLTAVSTSTPAASTSSTPPPHASQKERTSSTSSAPNFRNITPVSSFLSAKKLDPDGFPRVSRDVMKAKSLIEIVGQENFFVDLHTLFCRLLHSLIKQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYR6</accession>
    <name>R0IYR6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="8" type="ORF">SETTUDRAFT_167639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022808.1">
        <property type="nucleotide sequence ID" value="XM_008024617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IYR6"/>
    <dbReference type="STRING" id="671987.R0IYR6"/>
    <dbReference type="GeneID" id="19400255"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="242"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA89920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="436" mass="50236" checksum="04D3E0910C298171" modified="2013-06-26" version="1">MADSAAAGANVAEQYSLLPKLMPHLDRHLIYPLLNFSSDEEAEQTAEQKKLLLELLKPTNMTDFVGQLHQEVHGLADMSDEYKKKREEVLQKRDQLEDATSKISGLLDDENVVTNLRSDKQQNLAYLKESHGVDMEMVNQLLEFGQFQYSCGVYPHAAELLYRFRVLTTDGDKEREATWGKLACEILSVNWDSAMEEINKLKEIIDTRLFNNPLAQLQHRTWLIHWSLFPLFNHETSRETLTDMFFSPAYINTIQTSCPWILRYLAAAVITGRNRGRNSNQYQKQLKDLIRIVRQEGYEYSDPVTDFIKALYIDFDFEEAQKKLGETEEILKNDFFLLGAADQFVDAARHLISESYCKIHQRIDIKDLSTRLGLSQDEGEKWIVNLIRDTRVDAKIDYQAGTVVMNHPPQSVYQQVIERTKGGFFRTQVLSAAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZ99</accession>
    <name>R0IZ99_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_167603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022777.1">
        <property type="nucleotide sequence ID" value="XM_008024586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IZ99"/>
    <dbReference type="STRING" id="671987.R0IZ99"/>
    <dbReference type="GeneID" id="19400239"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_4_2_1"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="484"/>
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                <person name="Wang R."/>
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                <person name="Han J."/>
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    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03524">
        <property type="entry name" value="RPA2_OBF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA91665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="253" mass="29137" checksum="56EF6420DBACC372" modified="2013-06-26" version="1">MSTRPYRLYPAYCFRASPTFNTWVKLTAAGVQALRSEKDFEGQRIYFHLNHPIRYVRLVGAVVAIDDINLRYTVLTLDDGSGATIELKIVRTIPADKNPVDTSSKTEVDNVDIISRLGVFEVTVDSQPLDIGSVIKAKATISEFRGVKQLEMKRVSIVTTTDEEARAWAETAAFKQKVLSKPWHISSSEHRKIKHSIKAEKKQLREYERRKAEYEVKKEEHRLARETYNQEREKKLEARRRKEEVIMNAGALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0J5S5</accession>
    <name>R0J5S5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_73012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020331.1">
        <property type="nucleotide sequence ID" value="XM_008022140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J5S5"/>
    <dbReference type="STRING" id="671987.R0J5S5"/>
    <dbReference type="GeneID" id="19405378"/>
    <dbReference type="eggNOG" id="ENOG502SNM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_8_5_1"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA92066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="308" mass="35672" checksum="B3D48CD6BEEFBFE0" modified="2013-06-26" version="1" fragment="single">YFIDVEKYCLVAQPQFGHSFRYAALSYVWGKSTDNTFQTLIENFDSLSETNAFKLPENYGRLPNTIKDSIFLTRALGIQYLWVDRFCIVQDDETAKPYQLAAMASIYSNSYVTIAATEGPHSNYGLCGIEKSRPRKPPFEILDFSPSRRMFAASPTRSTRDIYHSRGWTFQEWTFSRRMIVFHDQTVTWVCQKYMQQENGHTPFRVPARTPLTLWTKRPNPGSYCAEVEQYSSRNLSDPADVLAAFDAFITVQGRAMKGGMLYGLPELYFNNMLCWHHDFGSVQNRRRDREGNILKQFPSWSWAGWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJN7</accession>
    <name>R0JJN7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_165971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030967.1">
        <property type="nucleotide sequence ID" value="XM_008032776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JJN7"/>
    <dbReference type="STRING" id="671987.R0JJN7"/>
    <dbReference type="GeneID" id="19399650"/>
    <dbReference type="eggNOG" id="KOG3066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067225_2_1_1"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA81528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31049" checksum="AD2CF3CAFA34B191" modified="2013-06-26" version="1">MFEGFRAELDEHHDRRERIIKASRDITASSKKIIFTLQRVRTIGQALPPWVTKKNAEYWETIEDRYKNIAADLQGLNAYRYSHNITGGNQEFMEALSFQHYLETQSLISYEEAKARINAMSGGAGPINFTPEDYILGVCDMTGELMRFSVTSMATSGKLPSGKQAESNKRLKHDHEEDGGDKMEIDEQAPAASEAQKPRTVLDDLRAVRLQLEMFDVRGGSKFAAELETKKMPVMRECVDKVEKGLYGLTVRGNERPKGWMPDMSSGRGAEVESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLZ3</accession>
    <name>R0JLZ3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_34987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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    </reference>
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    <sequence length="417" mass="48128" checksum="8036EB86807F4EA1" modified="2013-06-26" version="1">MANRIMYRSYWIPEMNDTPPNKLGRLTAWRGQAFPIGGLMRWSLDLPPERLKNAMEGKMRMSAERYSMDQRDFKAVKQTIDAAVKYFKDGKSLNFTSIKVDELDSLWPDGVTAMEQLTDLVHCEDDTKVRRRFYQAFGIEILEKALKQKGNGNPTARDIEQLLGTDKYKALRDTISSAATARLQHHLSLPISFTELVLCRRDKKNQQKAQQIVAIFGAYMENIQHFPFVPEKTPMSARLKEFFKVTNFPGSKDEWFTISQTHWHSFEEARNYTRTIGFSEHIENTDDEEILRINSLYGRELQYHNLLCVKHESMEFLTVATAITPGTILGIIPNEHRYPHPRQPERHWLRLPKGVYCEPLPSPFTLLFQREVSESSPGNISLGYDRIRDPFTGVAPTYRLFAVATEPIAPLEPLIIC</sequence>
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    </gene>
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Exserohilum</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
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    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030534.1">
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    <dbReference type="STRING" id="671987.R0JM12"/>
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    <dbReference type="eggNOG" id="ENOG502QQNE">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
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    <dbReference type="InterPro" id="IPR012094">
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        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
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            <end position="250"/>
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            <end position="624"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JPS9</accession>
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        </submittedName>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
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    </reference>
    <comment type="similarity">
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    <dbReference type="Proteomes" id="UP000016935">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="39"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="131"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="357" mass="39457" checksum="960B25B6EEBB3CCA" modified="2013-06-26" version="1">MIDQTKSYTIKPRVLYLGVPKHQSSRIRDQYSELFDIDILDVSTRAEALEDIPRIVASRGPYQCLVCRLGPQPFEPFDSQLLGPLLPDLRIVVSAQSGFDDFHVDWMTRQGIWFCNTRHAMVESTAEMALFLIMAVSRNTSRAEQSLRSGMWRGRLPLSRDLRSTTLGIVGMGSIGACLARKAVALGMQVRYHNRSGKAAGNKAPAGSVCCATLDELLQTSDIISLHCPLTPGTRHLMSDKQFQMMKDGSYLINTARGGVVDSQALIRALEKGKLAGAGLDVFENEPTGIDPYFLESDKVVPIPHMGGLTEGSFEIAEQECLTNLQEIQQLFPSAEIASTEFDRVHYFGGGYWPIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0JQ32</accession>
    <name>R0JQ32_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_61372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028886.1">
        <property type="nucleotide sequence ID" value="XM_008030695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQ32"/>
    <dbReference type="GeneID" id="19405267"/>
    <dbReference type="HOGENOM" id="CLU_073903_1_1_1"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="141" mass="16032" checksum="9FE1A6ACF61D7CC3" modified="2013-06-26" version="1" fragment="single">HIQEVLVLPGAPSAVRYEAVQPVPVEGVYSNEAPWLVVYEMPDIEYRSSDAFLNLSVRNPPPKELIDEIYMNTRFDVRFYEEKQKKRGGNTHIKTSAPATFVISSALHPASDADSLTSFDSWYREEYLPALSRIPGFVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JS67</accession>
    <name>R0JS67_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_138658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028394.1">
        <property type="nucleotide sequence ID" value="XM_008030203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JS67"/>
    <dbReference type="STRING" id="671987.R0JS67"/>
    <dbReference type="GeneID" id="19396475"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_2_1"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="185"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA83953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40492" checksum="3B2B7410C8F86D6F" modified="2013-06-26" version="1">MTDSTYQPLSGLWEPTQLQRLHYGADSVNKYLLACLPKESSKAFVITGNSLATKTPLVKQVEELLGGKHAGTFSKIGEHAPVAQLDEATDLVQKDGSIDTVISIGGGSPIDSSKAISYRLHEKTGKFLHHIAIPTTLSASECTFMAGYTQANGVKTGVKAQELAPQVVLYDAKFALHTPERLWTSTGLRALDHAIELLYHPTASEMPARWLALQSAATLLDALPKYKKSPKDEDLITKLQLAAFGSLGSLGYNVKGGLGLSHALGYALGSPYGIPHGITSCLTLGHVVKLKAQDPSAAQQVARLLPFIGEPVSGNTQADAALVGDRILKLVKDLELDSDLRNYKVGRDQIPVIVERATGGMKEGLIHDAVEGLVKGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0JV92</accession>
    <name>R0JV92_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Steffenson B.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025218.1">
        <property type="nucleotide sequence ID" value="XM_008027027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0A6"/>
    <dbReference type="STRING" id="671987.R0K0A6"/>
    <dbReference type="GeneID" id="19398540"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="14915" checksum="5CE3A11DE3CB047C" modified="2013-06-26" version="1">MSGKRGRGSTSGNKLKMTLGLPVGAVMNCCDNSGARNLYIISVKGIGARLNRLPAGGAGDMVMATVKKGKPELRKKVMPAVIVRQSKPWRRADGIYLYFEDNAGVIVNPKGEMKGSAITGPVAKEAAELWPRIASNSGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0K119</accession>
    <name>R0K119_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_19358</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024901.1">
        <property type="nucleotide sequence ID" value="XM_008026710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K119"/>
    <dbReference type="STRING" id="671987.R0K119"/>
    <dbReference type="GeneID" id="19402188"/>
    <dbReference type="eggNOG" id="ENOG502RXSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2172644_0_0_1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF18">
        <property type="entry name" value="MALTOSE FERMENTATION REGULATORY PROTEIN MAL13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="110" mass="12043" checksum="BDEB2758826EC0A9" modified="2013-06-26" version="1">MAMAPRKGTRRACDPCSVRKVRCDGNQPCARCEAAKWDCTYLKTHGKSGPKGPRRTTEAAIRRLQERSKTSHHGSRSASETSRETGSPVNELPYLTPLPHVGDANLDPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1V2</accession>
    <name>R0K1V2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_19624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024929.1">
        <property type="nucleotide sequence ID" value="XM_008026738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1V2"/>
    <dbReference type="GeneID" id="19402216"/>
    <dbReference type="HOGENOM" id="CLU_1856537_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="138" mass="15321" checksum="4FE304664CDB957E" modified="2013-06-26" version="1">MSSIETVIMPNTSSSSILAGAEDQDIMITYPLTRVWANTPLIVPTSNTASTSLRHHHHHNRRANAHEDEEDEDMHLCTLALCTVDSVDLIRRDTAERNTRRSSASSRTASEIKGKVGGLVGVLNQKVRGWVRRLSCKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2E3</accession>
    <name>R0K2E3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_164211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028279.1">
        <property type="nucleotide sequence ID" value="XM_008030088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2E3"/>
    <dbReference type="STRING" id="671987.R0K2E3"/>
    <dbReference type="GeneID" id="19399040"/>
    <dbReference type="eggNOG" id="KOG2081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005996_0_0_1"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA83789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="952" mass="107524" checksum="6CE543180012ACD2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3M9</accession>
    <name>R0K3M9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_119226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028541.1">
        <property type="nucleotide sequence ID" value="XM_008030350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K3M9"/>
    <dbReference type="STRING" id="671987.R0K3M9"/>
    <dbReference type="GeneID" id="19395775"/>
    <dbReference type="eggNOG" id="KOG2463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024666_2_0_1"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="452"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="140"/>
            <end position="151"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Steffenson B.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5D0</accession>
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                <person name="Henrissat B."/>
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                <person name="Bushley K.E."/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11659" checksum="25ED897E63B804A0" modified="2013-06-26" version="1">MASPESWSQRLREHCLVRGLPEPTYTDLSDRRGGRTAWTTMVAVSGTSYQARFWYDGTYLHQAKEDCSEVALRSITGYTNSAQTPPPASHYRSLATQLDQSITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6S4</accession>
    <name>R0K6S4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_163922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA85239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6S4"/>
    <dbReference type="STRING" id="671987.R0K6S4"/>
    <dbReference type="GeneID" id="19398947"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="formate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="29"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="150"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA85239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37592" checksum="D6E9CA9EC63AC9A4" modified="2013-06-26" version="1">MHHEIVALEKQLQPLPIDGFGLPAGTTYTLTVYESTPSRELLHARIRHATIVIVTTVRLDAETLHPTVTPHLRYIAVSATGTDPVDLDACRARRIRVTNCPGANLDAVSEHALGVYFAARRRTVLLDRVTRAQPSEWRDKGSVIHCMRLPDGTPPVTCSDEVMGIIGYGGLGKRIAALGRALGMRVLVASRKPPAMPVSSGFVPTPSTSDDGRIPFDEVLRQSTVLVLSLPRNPDTLNLISTPELAHMNPYTVIINIARGGIVHEAAVVQALRERRISGYATDVFQVEPAGGPQDSPLLEEDTKGLNITMSPHVAWFAQRTIKNLGDILKATVQGWVSGQEINVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7F7</accession>
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        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 35 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_21565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028032.1">
        <property type="nucleotide sequence ID" value="XM_008029841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7F7"/>
    <dbReference type="STRING" id="671987.R0K7F7"/>
    <dbReference type="GeneID" id="19402450"/>
    <dbReference type="eggNOG" id="ENOG502QUR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027430_0_0_1"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000135">
        <property type="entry name" value="Beta-galactosidase, putative, bgl35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.20">
        <property type="entry name" value="putative beta-Galactosidase from caulobacter crescentus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040719">
        <property type="entry name" value="DUF5597"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18120">
        <property type="entry name" value="DUF5597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 42 N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5597" evidence="4">
        <location>
            <begin position="394"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA84207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="559" mass="62482" checksum="455DBDB2D8BC39D4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7L4</accession>
    <name>R0K7L4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_92831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Manning V.A."/>
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                <person name="Han J."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908648">
        <property type="protein sequence ID" value="EOA85719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026664.1">
        <property type="nucleotide sequence ID" value="XM_008028473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8D0"/>
    <dbReference type="STRING" id="671987.R0K8D0"/>
    <dbReference type="GeneID" id="19395491"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA85719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57100" checksum="46C60A0652CAEE9E" modified="2013-06-26" version="1">MPNIEPHSYKLYYAYGFVPIFLFFLARYVYQTLASPLRNVPGPFLARFTRLWELQSIRKHDNPTLNIALHERYGKLARPVVRLAPNGYSLNSSESAKVILGHRNGLDKSKYYHPFGLASVFNVFTETRLSVHATIRRPLAQLYSQTALLSYEPFVDTCNSLLLKRLEEYAENGETMDLRDMMQFYAFDVIGEITVGTRFGFMEVGDTTGIITAIEKGTTYACFMGLLPEWHWWVSKLSEILKRQPGFKKVVNFVCHHVDNRISGRTKSPGDHSDFLDKMLRVEKEGKATRFHIEEATIQNINAGSDTSAIALTTAIAHLCVYPNTLAALRNELDAAAAAAAAGSLSDPVTFQEAQKLPYLQAVIMEALRIHPAVGAPLTRVAGPEGLQIDGYYFPPGTEVGVNAWAVHNNTSIFGPDAHVFRPERWLTENKEERAVLDRNLLSFGNGARTCIGKNISLMEMSKVIAHIVQKYDFDLQPNDQGQKFSWKTRWFAKPIVHAVVKRRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8V4</accession>
    <name>R0K8V4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_55134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026427.1">
        <property type="nucleotide sequence ID" value="XM_008028236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8V4"/>
    <dbReference type="STRING" id="671987.R0K8V4"/>
    <dbReference type="GeneID" id="19405208"/>
    <dbReference type="eggNOG" id="ENOG502SUWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668295_0_0_1"/>
    <dbReference type="OrthoDB" id="5372703at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="219"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="412" mass="45548" checksum="517EF809BDD6428F" modified="2013-06-26" version="1" fragment="single">LVERWLSNCSCIYKQEEMAPSTPRSASISLHHSMNRHRHGQGSQTSTRTKIPQPQTYRKRNMHHAGVHIGQLAELPVGIDEQVRGILGIRSWGDRVAAPNTLETESRFTGLAERFLADSKKNASDCSLEADWQLSLSSVVRAIADFSNGVVGAHATEKVWNSDLKPTASLLDESHDEVQRGTAVTFTSTQPRFPSFTQSRVTTDSTDNLGSVSMPSYSESVASTTSTQAAGPYYITTPKPDITVGLADTAFILNHQRLLVDHQAAGSTISDPHAAEIGIRFPFLIVESKGWSSKGTLISAQNQAAVGGACMLKILKDLSYQAMRGPGTDLKSDLAEHHLPCQRFVFSIVNEGPVYELWVHFEFEDTFHMQNLQTWRTTKQRGAEELVNSLGHIMEWGKGKFKDCIVDRLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBE6</accession>
    <name>R0KBE6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_79497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908687">
        <property type="protein sequence ID" value="EOA85552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026818.1">
        <property type="nucleotide sequence ID" value="XM_008028627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBE6"/>
    <dbReference type="STRING" id="671987.R0KBE6"/>
    <dbReference type="GeneID" id="19405425"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
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            <end position="545"/>
        </location>
    </feature>
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        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="61283" checksum="E94B52F40C17ED8A" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBM0</accession>
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        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">SETTUDRAFT_111648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908670">
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        <source>
            <dbReference type="EMBL" id="EOA85607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="55830" checksum="21910A525ACD214F" modified="2013-06-26" version="1">MPYVPQLGLAQGTSMAEHDFSVPGSKSYYSSSTVVSGGLVADSGGCVRKDSLTSKYGIFNDTDLLISDDGEHNDTGDIQRHERATQIRHAPLLGVDVILQNDQHLLPQYGLIGLYGEAKDIRSKLFMNTNVPFSMFLCGVQGSGKSHTTSCILENSLIPSKHLGRLQNPLSALVFSYGHFNGDGIGFSISEAAFLGSSGARISGAAHVKKVHVLVSPSNYVRISKLYLQLPNVSVTPFKIKHRNLNITTILTLMNVNESEETPLYMAQVTQILREMSTTGGPFDYKAFKLHPKKQKFNPAQTNMLQMRLSLLESFLDMTDTSPEMAFLPGEITIMDMSCPFVDANTACVLFEIGLQQYLQSKGTGKMIVLDEAHKYMLKIPGAKSLNGALLQTIRLQRHHGARIIVSTQEPTLLTDLIALCSVTVIHRFSSPAWFSAIRRHVPITDENRDDLMRKIESLKTGQAIVYSPNAVLGFDDCSRLVMGTSGMIYVRVRRRLTSDGGQSVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBR4</accession>
    <name>R0KBR4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_132316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908659">
        <property type="protein sequence ID" value="EOA85632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026715.1">
        <property type="nucleotide sequence ID" value="XM_008028524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBR4"/>
    <dbReference type="STRING" id="671987.R0KBR4"/>
    <dbReference type="GeneID" id="19396150"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_12_1_1"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="39"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA85632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="400" mass="43582" checksum="F9A58ED8D0761599" modified="2013-06-26" version="1">MTTSTPTRHQHAGHCHHHHDNTFLLSKNKNDAGVRITRVGLYVNLGMAISKGFGGYVFNSQALVADAIHSLTDLVSDIMTLATVGWSLKPPTQRFPTGYGKVESLGSLGVSGILLGGGFFMGWTALIALCQQFFPGAAEVAEHWGLLPHHHHHHHHGVDGLGPNINAIWLAAGSIVIKEWLYRATLKIAEERKSTVLASNAYHHRVDSLTAFVALLLIAGSNVFNNAQWLDPVGGLVISLMVVQAGWGNTKQALLELADVGVDQEMKDNVRKAAAKAVQEITTSAEPVNVRAIQGVKAGQNYLMDVELGVAGAWTVDQTRRVEDVVRERIGAQVRGVKKVRVRFVSNTAQEPDFLDEFIPADSAATAESEHDHSHDNSHDHDHDHNDKHSATDSSARRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KC39</accession>
    <name>R0KC39_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_163057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025502.1">
        <property type="nucleotide sequence ID" value="XM_008027311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KC39"/>
    <dbReference type="STRING" id="671987.R0KC39"/>
    <dbReference type="GeneID" id="19398638"/>
    <dbReference type="eggNOG" id="ENOG502S6UI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160285_2_0_1"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA86959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="82" mass="8873" checksum="5FF274871288CD1E" modified="2013-06-26" version="1">MPAAEQTSADARRKAAREVIDILHEIATLLNTHLDRQQLSYCVSLIENGANPEALAKVILQLREEYPTSSIDGDAEAGAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KC67</accession>
    <name>R0KC67_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_178891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025522.1">
        <property type="nucleotide sequence ID" value="XM_008027331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KC67"/>
    <dbReference type="STRING" id="671987.R0KC67"/>
    <dbReference type="GeneID" id="19401640"/>
    <dbReference type="eggNOG" id="ENOG502QU74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011527_0_1_1"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="62402" checksum="AF2393B1336455B8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCD6</accession>
    <name>R0KCD6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 69 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_161615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA85877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028271.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19398180"/>
    <dbReference type="eggNOG" id="ENOG502QRBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343222" evidence="1">
        <location>
            <begin position="33"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="426" mass="48788" checksum="CF37E137CAD7F6DC" modified="2013-06-26" version="1">MGAYRGMRMLLRVLASLIFVFFLIAELAPSHSRDILSAIEYSFTVLVYSSTAGVRLDPQELVPKTGKETYDEAEAQTNPYIHAIMDPSDSAFSRLECPQPKLERYNYLRDLTESSALDQLPKYVFALDLHQSIDILPRLIGSIVESIRFLGPQNCVLSIVEGRSDDGTIEVLDELRSSMELLGIRYQLQSSNLNPTATGTDRIESLAKLRNLALEDLIAYPEQYDKDTTVIFSNDIALCMEDFLELIHQRKFLGADQTCAMDWTYVGENPTFYDVWIARGMTGDLFFNIPEDGSWDNAWNLFWNDQKTRMRLYTWRPFQVFACWNGVTAFTAKPLMEKKIIFRAHKEGECFQGEPNLFAKDMWFHGYGRTAVVPTVNVEYSDEAAKKIKQLEGYVSKHVENERGDIAIHWDTSPPKNVKCMPDYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCU7</accession>
    <name>R0KCU7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_184791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028107.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0KCU7"/>
    <dbReference type="GeneID" id="19402053"/>
    <dbReference type="eggNOG" id="KOG1822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000503_0_0_1"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1855"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1998"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2010"/>
            <end position="2021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA86017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="2032" mass="220724" checksum="00E409DFD9932C43" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCZ5</accession>
    <name>R0KCZ5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_87333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025692.1">
        <property type="nucleotide sequence ID" value="XM_008027501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCZ5"/>
    <dbReference type="STRING" id="671987.R0KCZ5"/>
    <dbReference type="GeneID" id="19405643"/>
    <dbReference type="eggNOG" id="ENOG502S35J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024412_2_0_1"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="147"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="526" mass="56370" checksum="22DEAFF89651DF0E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDP0</accession>
    <name>R0KDP0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_110193</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026250.1">
        <property type="nucleotide sequence ID" value="XM_008028059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDP0"/>
    <dbReference type="GeneID" id="19395404"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF42">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="540" mass="59499" checksum="EFDCFCA4F4B27E42" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDP2</accession>
    <name>R0KDP2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_166860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021679.1">
        <property type="nucleotide sequence ID" value="XM_008023488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDP2"/>
    <dbReference type="STRING" id="671987.R0KDP2"/>
    <dbReference type="GeneID" id="19399955"/>
    <dbReference type="eggNOG" id="ENOG502RDU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056802_1_0_1"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354117" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="40"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="254" mass="28099" checksum="F5722D9D944B4ADA" modified="2013-06-26" version="1">MYLSNALLGLISLATATHVPAPQHLFANPSSADGSVYKIPTVHESAVQARRIMRLENIGTLSTVFPSPPHSTEQRPSDVGGTPIGLMDYFGDCEPDTGNPTILAITIATSFKNVNAGSNITLSMRWHPQDNKWRSPASLPRFSLIGHLEDIDMDAIEKLGVTACFVKKHPDAAWWLPGNRIHESKWVRLVVDEIYWIGGFGDRAYIGWIPKDEWFSVTQEEIDSIQLPGEKSSAWGTLGTWFGLGQQEQGIFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>R0KE41</accession>
    <name>R0KE41_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_169193</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
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        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA86432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
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        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
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        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
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        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
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        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
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        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
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    </dbReference>
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    <dbReference type="PRINTS" id="PR01161">
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    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="249"/>
            <end position="394"/>
        </location>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <lineage>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908548">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502T521">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="759" mass="84172" checksum="63C227CDD99DCDBD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGU5</accession>
    <name>R0KGU5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">SETTUDRAFT_107606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023896.1">
        <property type="nucleotide sequence ID" value="XM_008025705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGU5"/>
    <dbReference type="STRING" id="671987.R0KGU5"/>
    <dbReference type="GeneID" id="19395244"/>
    <dbReference type="eggNOG" id="KOG3185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="246" mass="26395" checksum="A627DA6564C0273D" modified="2013-06-26" version="1">MAVRAQFENSNEVGVFSTLTNAYAIVAVGASENFYSVFEAELQDVIPICHATIAGTRIVGRLTAGNKKGLLVPTTTTDQELQHLRNSIPDEVKIQRIEERLSALGNVICCNDHVALVHPDIERETEEIIADVLGVEVFRQTIADNVLTGSYMALSNQGGIVHPKTSIQDQDELSSLLQVPLVAGSVNRGSAVVGAGMVVNDWMAVTGLDTTATELSVVESVFRLGEGNGPANINTTHKDAMVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KH19</accession>
    <name>R0KH19_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dimethylglycine oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_31638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025081.1">
        <property type="nucleotide sequence ID" value="XM_008026890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KH19"/>
    <dbReference type="STRING" id="671987.R0KH19"/>
    <dbReference type="GeneID" id="19403564"/>
    <dbReference type="eggNOG" id="KOG2844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_11_2_1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="381"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="438"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="747"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA87367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="93696" checksum="1783708D898D0EA2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0KI51</accession>
    <name>R0KI51_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_47173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024561.1">
        <property type="nucleotide sequence ID" value="XM_008026370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KI51"/>
    <dbReference type="STRING" id="671987.R0KI51"/>
    <dbReference type="GeneID" id="19405116"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="54"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA87702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="492" mass="51166" checksum="78FDC46C8804EBEB" modified="2013-06-26" version="1">MPASTTLLSRAGAQLSLRGSIALRGALPAATCSARTPALAALARYYASKSYPPHSVISMPALSPTMTSGNIGAWQKKVGDSIAPGDVLVEIETDKAQMDFEFQEEGTIAKILRDAGEKDVAVGSPIAVMVEEGEDVSAFESFSVDDAGGDKKPASSPKQGEASEASEPPSTGSKTAPPAKEAPAPAAIESDSTGARLETALQRQPAVSPAVKKLALEKGVPLGSIKGTGKGGAITKQDIENYKPAAGAAPAAGSAFTDVEASSMRKVIASRLTESMQQNPHYFVASNISVSKLLKLREALNSSANGAYKLSVNDLLVKALAIAARKVPAANSSWREEGGKVIIRQHNTVDVSVAVSTPVGLMTPIVKNVNGLGLETISSQIKDLGKRARDGKLKPDEYQGGTITISNMGMNPAVERFTAVINPPQACIVAIGATRKVAVPGEATEDGSASIEWDDQIVITGSFDHKVVDGAVGGEFMRELKKAIENPLELML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KIC2</accession>
    <name>R0KIC2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RSE1/DDB1/CPSF1 first beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_47226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
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            <topology evidence="1">Single-pass type I membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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    </feature>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023416.1">
        <property type="nucleotide sequence ID" value="XM_008025225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KL87"/>
    <dbReference type="STRING" id="671987.R0KL87"/>
    <dbReference type="GeneID" id="19395140"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF9">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="285"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA88732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="408" mass="43766" checksum="1D5D1928DF1B0C2A" modified="2013-06-26" version="1">MATFTKAARSILQKSPNDVVLLSAVRSPINRSFKGGYKDAHPEDILMPVMKAAVQRAGIEKSDVNDVMIGNVLAELGFAKTGRMALNHAGFPNSTTFHTVNRRCSSSLQAITHIAHSIMVGQIDVGLAGGVESMSRNYSSRGIPTDVSPTLLGSNVKDAHDCLMPMGITSENVAERYNVDRKSQDEYAVRSHGRASRAQKEGRFDWETVSVKVQRIDEATGQPAEFEVTKDDGIRHGLTFEKVSGLKPVFGENGKSTAGNSSQISDGASSTILARRLWAEERGLQPLGRFVGTQVKGCAPDEMGISPVFAIPALLKWTGVELKDIDVIELNEAFASQTIACIRKLGLDEDRVNPNGGAIALGHPTGATGARQTATLFGELRRQDKELGIVSMCASTGLGVASLFVRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLP3</accession>
    <name>R0KLP3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_36700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021869.1">
        <property type="nucleotide sequence ID" value="XM_008023678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLP3"/>
    <dbReference type="STRING" id="671987.R0KLP3"/>
    <dbReference type="GeneID" id="19404174"/>
    <dbReference type="eggNOG" id="KOG3200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059836_0_0_1"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="113"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA90039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="302" mass="32936" checksum="3F2E3293DB0ECDEE" modified="2013-06-26" version="1">MTDQETFGAKHDLEVFRVTSLPRSFYYIPNFISAEEEASILQKPTSGSSNMPNLCKIPAQRWTHLSHRRLQAIPSTLTKNNTLLASPLPAYLTTPVVDRFKALGIFEHTPHQQPNHVLVNEYRPGEGIMPHEDGDAYAPVVATVSLGAALCLDVVRKPAKARDEEDGSSNRRRSSSENGPVAAPEDQIHDGEEEKEEASSSSSSSTNGEFKLPTRIYQERRSLLVTTGAAYCTLMHGISGIAVDEGLNEESVANWQLVGDTRTLEAMGGMSARGVRTSLTYRDVLRVSAAASKVLGGGFPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KM88</accession>
    <name>R0KM88_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_106166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023654.1">
        <property type="nucleotide sequence ID" value="XM_008025463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KM88"/>
    <dbReference type="STRING" id="671987.R0KM88"/>
    <dbReference type="GeneID" id="19395152"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029367_2_0_1"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902413">
        <property type="term" value="P:negative regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000039">
        <property type="entry name" value="Cell division control protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="38"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="335" mass="37067" checksum="CF8505BB1CE73A33" modified="2013-06-26" version="1">MTNLDMLLLKGASASDAEEYLQELRYTILTKGIPANSEGMSELRIYIWLILLNAPPLRTDVYLDLVRQGASPAHAKIQNDTFRTFQGDPLFRRRVTQNSITRVLNAVAWRLNDAHEARVNGWQSPPTLSEFGGSPDTSTIMSRHSATTGGARTEASTTNDAEQIGYVQGMNVLCGPFLYAARSEVEAFTAFEKLITHECPGYVRGSMEGVHKGLALVDRVLEVVDPKLFEHLMAHHMEARIYAFASVLTMCACTPPLPEVLQLWDFLFAYGPHLNILCIVAQLVLIRADILNSPSPNTILRNLPSLNAQKVIGVAMSFAGKIPEDMYAEIINHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KN87</accession>
    <name>R0KN87_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_103700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022352.1">
        <property type="nucleotide sequence ID" value="XM_008024161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KN87"/>
    <dbReference type="STRING" id="671987.R0KN87"/>
    <dbReference type="GeneID" id="19395001"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010969_1_0_1"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344444" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="168"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA90534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="709" mass="78542" checksum="4C0FF9DC21457FFD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KP34</accession>
    <name>R0KP34_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_36331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021285.1">
        <property type="nucleotide sequence ID" value="XM_008023094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KP34"/>
    <dbReference type="GeneID" id="19404119"/>
    <dbReference type="HOGENOM" id="CLU_090372_0_0_1"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA90829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="212" mass="23948" checksum="CA7C038911667606" modified="2013-06-26" version="1">MESSSGFGPKVAIPQLKRPNQQTVFSKSPRISSERVSQALLFVDILCELTCVELKCSGTRPRCTNCTKYDEDCIYHLSRRDRLREAAHKIEVLSTLLKDIRGALNDENAKRIDDVLKEFEDDTPPLPPSVHTKSWNKRLRPSSPNEADCDRQALNKAHVSSSVDSNKDLNFLEEDVLENLRPIEANYMGCNSQIAWMTTLQRSQDQSGRGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQT8</accession>
    <name>R0KQT8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_167089</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022056.1">
        <property type="nucleotide sequence ID" value="XM_008023865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQT8"/>
    <dbReference type="STRING" id="671987.R0KQT8"/>
    <dbReference type="GeneID" id="19400034"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012842_1_0_1"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000458">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001875">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="551"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="517"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA90147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="594" mass="63652" checksum="577C1BAD8F94B8A1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0KR30</accession>
    <name>R0KR30_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19402150"/>
    <dbReference type="eggNOG" id="ENOG502SB4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5304367at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA92339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="138" mass="15341" checksum="B1E6BABBE0760FA1" modified="2013-06-26" version="1">MPKAADGMSEASKPTSGNAPPRLSRNRGIINGRTVMAPLAAFTMAGLLFVYARTSIRAAKLNAQKHREADGGQISWHKESLRRHGQIERVDDDRGTFGEALMGDIRRKKQQKVEENQNVSTERSDNEAELRKIIGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTZ0</accession>
    <name>R0KTZ0_EXST2</name>
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        <recommendedName>
            <fullName evidence="7">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020015.1">
        <property type="nucleotide sequence ID" value="XM_008021824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTZ0"/>
    <dbReference type="STRING" id="671987.R0KTZ0"/>
    <dbReference type="GeneID" id="19401661"/>
    <dbReference type="eggNOG" id="KOG3841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017049_0_0_1"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="7">
        <location>
            <begin position="67"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="67"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="675" mass="75821" checksum="A9B73DB2C66D1E87" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KUA2</accession>
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        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020166.1">
        <property type="nucleotide sequence ID" value="XM_008021975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KUA2"/>
    <dbReference type="STRING" id="671987.R0KUA2"/>
    <dbReference type="GeneID" id="19403374"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_080773_1_1_1"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA91377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="173" mass="20485" checksum="C5B5ABBCAF3E61DA" modified="2013-06-26" version="1">MFEAEYQIIGRHLPSEANPAPKIYRMRIFAPNEVVAKSRFWYFLGKLRKIKKANGEIVSVNQIHEKKPQKVKNFGIWIKYDSRSGTHNMYKEYREMSRVAAVEALYQDMAARHRTRFRSVQILKVVEVEKTDDIRRPYIKQLLTKNLKFPLPHRINKKAGKKVFSANRPSTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KVE6</accession>
    <name>R0KVE6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_80947</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020340.1">
        <property type="nucleotide sequence ID" value="XM_008022149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KVE6"/>
    <dbReference type="STRING" id="671987.R0KVE6"/>
    <dbReference type="GeneID" id="19405439"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_3_1"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="15">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="16">
        <location>
            <begin position="85"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA91722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37188" checksum="02C898F1C3CCB602" modified="2013-06-26" version="1" fragment="single">CLQSSLQAQDACAPTNTTCICLDAPLMTSISNCVLASCTLKQALVARNNTATMCGEPVRDNTRITPIISGVSGGAAILAILARCYAVGKSFAVDDLFAVISLILALPMGIVEFFMSVDGFGKDVWTLAPDKINSVVRLTWITEVFYFAAVATTKMSFLLFCLRIFPRKQFRRAAHILLVVCVVFCIVFTFVTIFNCIPVSYIWTNWDREHKGKCINFNAFTWSHAAINIFLDSIILGIPIPELLNLSMSSQKKIYIIMMFSIGALTTVVSIIRLQTLVKFAKSPNPTYDYVATAYWSVLEAFLGIFCVCMPALRRFLAILVPSCFGSTHNSNQYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KX26</accession>
    <name>R0KX26_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_30722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020254.1">
        <property type="nucleotide sequence ID" value="XM_008022063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KX26"/>
    <dbReference type="STRING" id="671987.R0KX26"/>
    <dbReference type="GeneID" id="19403462"/>
    <dbReference type="eggNOG" id="ENOG502S1UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017096_0_0_1"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA92257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="315" mass="34496" checksum="FFD6468A0248FBE0" modified="2013-06-26" version="1">MAVPMPLRHPPSQKDILHANQQSNRTLAPAAPIPVPNGSNPHLVYQHIHELASKRISTLDYLRKAHEGRIYWFNTLLFSKTDLTRLPSYTTRNQARRATHYLLLGFSLPTILDLNANSPSDYLKALNALLIEFEQYQSIHPPDGSTPSTLSRARLPQMFKRANMGMTMGMGSKGRRSSSATGDFPMLTPSNSFTGNESTSIDSPPTDDLLPNESYTHLQTPSLPFDPDFFSTFATLCDVLIDCYTRILSMLSTPESVTMAGGGAPSLVGDLFNKADTRVRKIILAGVVKEFEDSCRAGVKSEVGGVGKVVLGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5L5</accession>
    <name>R0I5L5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_35827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_140924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029761.1">
        <property type="nucleotide sequence ID" value="XM_008031570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IBF7"/>
    <dbReference type="STRING" id="671987.R0IBF7"/>
    <dbReference type="GeneID" id="19396591"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="440" mass="48510" checksum="E2095429F89C8EA2" modified="2013-06-26" version="1">MASSRENTSVIVVGGGGTIGSSTALHLVRSGYTPSNITVLDTYPIPSAQSAGNDLNKIMGIRLRNKVDLQLSLEARQMWKEDDLFKEYFHNTGRLDCANGEKGVEDLKQAYQALLDANAGLEETIEWLDSEDEILKKMPLLDRKQIKGWKAVYSRDGGWLAAAKAINAIGKYLCGQGVKFGFGGAGSFKQPLLAEGVCIGVETVDGTKYYADKVVLAAGAWSPVLVDLEEQCVSKAWVYAHIQLTPKEAAEYKNAPVVYNGDVGFFFEPDEHGVIKVCDEFPGFTRFKQHQPYGTKAPKRISVPRSAAKHPSDTYPDASEVSIRKAIATFLPRFTKKELFNRHLCWCTDTADAALLICEHPEWKNFVLATGDSGHTFKLLPNIGKHVVELLEGTLADDLAHAWRWRPGTGDALKSRRAAPAKDLADMPGWRHDEWATSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0IE60</accession>
    <name>R0IE60_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Glycosyltransferase family 57 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_120495</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029268.1">
        <property type="nucleotide sequence ID" value="XM_008031077.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IE60"/>
    <dbReference type="GeneID" id="19395820"/>
    <dbReference type="eggNOG" id="KOG1245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002631_0_0_1"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="WAC" evidence="17">
        <location>
            <begin position="483"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="16">
        <location>
            <begin position="939"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="734"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1005"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1233"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1460"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1511"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1156"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="29">28A</strain>
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    <reference evidence="28 29" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 30">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="KB908692">
        <property type="protein sequence ID" value="EOA85535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_008026835.1">
        <property type="nucleotide sequence ID" value="XM_008028644.1"/>
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    <dbReference type="AlphaFoldDB" id="R0IKA3"/>
    <dbReference type="STRING" id="671987.R0IKA3"/>
    <dbReference type="GeneID" id="19401560"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_0_1_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 24" id="KW-0274">FAD</keyword>
    <keyword evidence="7 24" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="17 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="26">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="27">
        <location>
            <begin position="210"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00037104"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EOA85535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="442" mass="49646" checksum="6FD797B29FFCDADC" modified="2013-06-26" version="1">MADCVYSLAEVAKHNSKTDLWVTLWNYVYDVTDYQEDHPGGKEFLLENAGADATTAYEDIGHSTDAREILENFRIGRLADDDWTDHEANKMPTIKPRRARIVDRLPPPKVSLTNLPAMGFGLASIVLSFAYGRKVSPYLHHLQSSGFWKGFAVSSIASMVIAGYASMWAAKRLDVAHMDLRAYPAHFRAKSTSSRPSRKKDINLGVLNARIYQPFPLIEKANISHDTVRLVFGLPSKNSILGLPTGQHVAIRHEADGKQITRSYTPTSSNKDLGRLELTIKIYEGGKLTPWLNKLNIGDMVEIRGPKGEMKYHKNLVKELGMIAGGTGITPMLQIIRRICEDPRDNTKVTLLYANKTEDDILLKDQLDKFTQENEQFKVHYILSNPSSSWQGEKGRISKQLIDKVFLCGPDPMVESMSMHLQERGFKAPGSISKPQDEIFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILI4</accession>
    <name>R0ILI4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_161640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026487.1">
        <property type="nucleotide sequence ID" value="XM_008028296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILI4"/>
    <dbReference type="GeneID" id="19398182"/>
    <dbReference type="eggNOG" id="ENOG502RXAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013219_0_1_1"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="474" mass="53813" checksum="27E501204C670580" modified="2013-06-26" version="1">MLTYSPPPAVICAENIALLYLLHSVPVPPSCNEIKKPPSRQGGYSSSFVQERDLASTLAFLSYTEDDPNHIPALCVEENPKLMSLDVVVAVNKKNEADGNEALQNIEQNLEKIFTILSEISQERDNNRAIEHQIFNAIISIYSHRVLSRLRFMAKTRGTPRQPLRVVLGEAINSLKQVNHQTLSSLPFSLFIERAKDVIRLADAWAKHQKSAELGNLVEGIYQLKQTGDVQALLGSIPNRAMGPSSRQNLFNIIKKVSRYREAARFLYRTAKKIPLLRRAKVVIASLPKEAFDRISDENYTPQLTSTISRMNTNCQGPVVRHLCRLLNTSGPQLNDQFADQTRKTMREAKIHAEIQLVFHYELNFSRLPPRVVCSSKDACFLCNAFILMHGKMHTPRYHGRLYPGWRLPLMSDLNDLDIRLNSALEDQIKDSLKTLLSRQKKTMVCHRPVALSRAKRNFTLQMSLRFTSSTSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IN15</accession>
    <name>R0IN15_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_169278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026165.1">
        <property type="nucleotide sequence ID" value="XM_008027974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IN15"/>
    <dbReference type="GeneID" id="19400850"/>
    <dbReference type="eggNOG" id="ENOG502S61K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101490_0_0_1"/>
    <dbReference type="OrthoDB" id="3877279at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="25829" checksum="14E154B62754FDD1" modified="2013-06-26" version="1">MQYSPALSAHSDMTDEELDKYFASCVPLSNLPTPPPAKEPTPTSHTCTCAPSPTQLAYATHLANLVPLNVSTHRPHASVIQGFLVRAALPDDVVAFAACLLDALSSRFAATWRDARQGIHVSPDVVVLAALSLAHGFLVDRLRSSRHWSLKESAAAFTVSQIEAAKRAMLHDMDYGLSRISHDMVQRRLRNMQPANASPALAAPPAPSAIKPSRRRNLSIALHGTAVWHHGVHTPEPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPS6</accession>
    <name>R0IPS6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_171101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025332.1">
        <property type="nucleotide sequence ID" value="XM_008027141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPS6"/>
    <dbReference type="STRING" id="671987.R0IPS6"/>
    <dbReference type="GeneID" id="19401081"/>
    <dbReference type="eggNOG" id="ENOG502QQ9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033363_1_0_1"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="2">
        <location>
            <begin position="147"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="464" mass="50742" checksum="C3E3406D319057B7" modified="2013-06-26" version="1">MGRHANPDIRRAFAEFQDQDTPSKCNKVRCRHCGFVRAKNTTRQIEHLQDCQAYLASSDAQAHVLAQQQDGTPVDGSTAAGPSPILSGQQPNPNLQVQRRGPNASKRARDGQPIAPVLAPAAPVTPSLTSHLLNTCAAPFRQATQRPFLSHAGCGSLAAEPLSQWLVQDGHYARGYIRFVGQLLAKIRLPQTPNSQFHPMYRTMDLLISALNNMRREMQFFEITATKYGLALGTEPPNPITRALMDLFVNATSSSASLLEGMVALWGTEHCYRSAWQYAATFTSALPTSASDSHIIALHQVLIPNWTSPASSKFLDATRALVDELANITTTRDGKEEMARCEEVFRQICWLAERFWPAIDDNGDEGPRPRIEGPMAAIGPTMDTTSMQGGMPNGLPMAMNRNNMHANMAGPSMHNTAINMHGNPVNTNTTNTNMAAPTQTPNMHPHNKYGMPHRKSMDSAGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPU3</accession>
    <name>R0IPU3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_162919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025346.1">
        <property type="nucleotide sequence ID" value="XM_008027155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPU3"/>
    <dbReference type="GeneID" id="19398587"/>
    <dbReference type="HOGENOM" id="CLU_2723816_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="72" mass="7555" checksum="A8399F40AD4791F7" modified="2013-06-26" version="1">MAGIAARTKGLKVTSSLEISTSRVILQATGSTASGGFCSLFHRFNASCKSPANTPYGFSPSIETESTCWHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQ94</accession>
    <name>R0IQ94_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_19417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024910.1">
        <property type="nucleotide sequence ID" value="XM_008026719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQ94"/>
    <dbReference type="STRING" id="671987.R0IQ94"/>
    <dbReference type="GeneID" id="19402197"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA86901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23191" checksum="7081A0093CABCD73" modified="2013-06-26" version="1">MVQTSYSNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDITNKKTFENTRKWVDDVRAERGNDVIIVLVGNKTDLNDKREVTTAQGEEEAKKNNLMFIETSAKVGHNVKALFKRIAQALPGMEGEGQQGQSQMIDVNINPSQPAQENSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQK8</accession>
    <name>R0IQK8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_153905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025652.1">
        <property type="nucleotide sequence ID" value="XM_008027461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQK8"/>
    <dbReference type="GeneID" id="19397350"/>
    <dbReference type="eggNOG" id="ENOG502S2YX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039318_0_0_1"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="482" mass="53186" checksum="ABC1EC85BA7019D6" modified="2013-06-26" version="1">MPASSSIQSYFAPSSTKNSDGFTRGEMQSALAPTGASAPSAWMPTVEYEEAELGSLEPGPRHLSLMGRIVNFNDQAKPSKSHKAAQGCIKVTLSDDTGVLTVRLWYAEARYKLKLGQLVSVWTVHISSSSEYNSLAPNSAPLFTSIFPESERHCHFMLHENSDDGTRFKRPYRVRESKVLTGLMTLKSFTDGGYDIDEPKLLVCVKSIGARKKYMNRNGTTSELVSLGIFDDTSEAVLTLYSTMCDSASLFVPSQTVLLISNPGWRIDKTAKLTITSNSRVDIDPDMGDARLLRALAQRLTKKEHVNPPFSIPHTQVADFEAASVKALYTLADIDSVARSLSISNSRETIAGYLSVIMTNLNIVSPFKRNMLLSTECCGIPLFSNQVTMQCRQCGNIVTLRINPRILGPIVDETGQISTGKLILADTAWCQLLGRTAQQLVETDIHVLRYLEQRLLFLRVTMGFALQLEDGIGRLAIWCVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQS8</accession>
    <name>R0IQS8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_163246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="match status" value="1"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="331" mass="36878" checksum="55FC0E901085401E" modified="2013-06-26" version="1">MGFGDFQSICEKASIPVCAVVGHQAINNGVGIQTRCFARTIEIANTLIFEVANDFMHILALVMTVVMIIHVRSKFTAVGRKEITTFFYIYMLLTIVSFVLDAGVTAPSSATYPYFVAAQNGLVSALCTCLLINGFVGFQLYEDGTTLSVWLMRLSSLTMFIVGGAVNLLTFKGWAGLSPGNPIGVFVVTYIVNAICLFIYVVSQIILVVGTLEDRWPLGDILFGIFFFVIGQVILYVFSDTICDGVQHYLDGLFFATICNLLAVMMVYKYWDSITREDLEFSVGVKQHNWELKEAYPEDDKRGTIYQDSDYTPSLYQQPYGRNSHYSVVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRL3</accession>
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            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Bushley K.E."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <strain evidence="2">28A</strain>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008025698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IV25"/>
    <dbReference type="STRING" id="671987.R0IV25"/>
    <dbReference type="GeneID" id="19400515"/>
    <dbReference type="eggNOG" id="ENOG502SCSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049925_0_0_1"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA88481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32435" checksum="E50B61C83835DD85" modified="2013-06-26" version="1">MDELRRRYHQDGYLFLKGLLPRQDVLAARQAYFEMLAPSGVLKPNTAPVDGIFDAARDAADFPGIGAGASPNNGKPGGTTASTFVDLVLQAHYADWYKETFCKHPLLKDFVARITGWADNTVAVRRSLLRNNTPGNKAIGVHYDQIFLRHGEPTSVTAWVPMGDISLTGGGLIYLENGHTLGREVEQDFTRKAAESGLSDEETRNAFNQNMLSTGLLADGPREYAQTFGRRWLVTSYEAGDVVLHNPFAIHASTINYDPNNVIRVGTDLRFVDGSKPWDKRWDKLYEFNDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IWP4</accession>
    <name>R0IWP4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_105259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023006.1">
        <property type="nucleotide sequence ID" value="XM_008024815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IWP4"/>
    <dbReference type="STRING" id="671987.R0IWP4"/>
    <dbReference type="GeneID" id="19395094"/>
    <dbReference type="eggNOG" id="KOG3100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075129_1_0_1"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA89155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="232" mass="26253" checksum="FA133FF01D82C6DF" modified="2013-06-26" version="1">MELPTHQPLAHDTDDDLSDDHIRDLLSEAAVRMRADAAQSASRPPAPFKLPKLTPAHIADTHETTDGNITRLDHSKLVDKNQKALANGIKKIEDPIQAKKQKQEEKKATAGAQWFNMPKTDLTPELRRDLQLLKMRSVLDPKRHYKKDNSKSDVPAFSQVGTIIEGATEFYSSRLKNKDRKQTILEEVIAQEQDSGRFKRKYEDIQTSKASGKKAHYKALKAKRNKGKIVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IX35</accession>
    <name>R0IX35_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_167709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022983.1">
        <property type="nucleotide sequence ID" value="XM_008024792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IX35"/>
    <dbReference type="STRING" id="671987.R0IX35"/>
    <dbReference type="GeneID" id="19400274"/>
    <dbReference type="eggNOG" id="ENOG502SBXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145518_1_0_1"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA89126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9024" checksum="6DB2B3EF0B76E488" modified="2013-06-26" version="1">MAPRPSITGFDPKKFAAASANGTKGDPWARYEQWRYTGPFTRFNRFKGSFPGLGIATVAFAGYLVAEQLFFQDKGHHDDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXS6</accession>
    <name>R0IXS6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_105656</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA89381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008024982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IXS6"/>
    <dbReference type="SMR" id="R0IXS6"/>
    <dbReference type="STRING" id="671987.R0IXS6"/>
    <dbReference type="GeneID" id="19395116"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025505_0_0_1"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="570"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
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        <location>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="517"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="615"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA89381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="694" mass="77532" checksum="28B0EB659049D124" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZ19</accession>
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        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
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    </protein>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502SQNJ">
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    </dbReference>
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        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
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            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="196" mass="22920" checksum="92013065CE809342" modified="2013-06-26" version="1">MPAKTSAKKMAPTPRPTDDIRLRRLARPSRESVEKQLSIPETISPLDNYPPLLRIPSEIRREIFRYVLPSSNKRFILYTDCDSRSISRKWNKICRPHPDQHLTLDILRTNRLIYHECLSVLYSENQFHFYAFNYLPVLDFIRHLSPEAKNQVRNVRLTPLTDKQDDPPASHDIFCTVIHDSLPGLSQLQADPVIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0J007</accession>
    <name>R0J007_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1993 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_146100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022211.1">
        <property type="nucleotide sequence ID" value="XM_008024020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J007"/>
    <dbReference type="STRING" id="671987.R0J007"/>
    <dbReference type="GeneID" id="19396852"/>
    <dbReference type="eggNOG" id="ENOG502S868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21205" checksum="4D7EF3E3D2D33CA9" modified="2013-06-26" version="1">MSLTFHAIAIAPAISALKNAHAFISKGHQHALANNIDPETYLAASLHPDMKDFRFQIYRATDAIKFVPPRINPALQDMTLPDEEKTFEELLARIEKTIKYLEGFSVQDFEGTEGNEVVLKLAAMGKQIRSPALEYVVRFAHPNMWFHLVTAYDILRMKGVDVGKFDFLNGAKSFVVEDLQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0A8</accession>
    <name>R0J0A8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease III homolog</fullName>
            <ecNumber evidence="15">3.2.2.-</ecNumber>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="15">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NTH1</name>
        <name evidence="18" type="ORF">SETTUDRAFT_167288</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022280.1">
        <property type="nucleotide sequence ID" value="XM_008024089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0A8"/>
    <dbReference type="STRING" id="671987.R0J0A8"/>
    <dbReference type="GeneID" id="19400119"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_4_1_1"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000027">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="17">
        <location>
            <begin position="178"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA90435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="508" mass="55638" checksum="8FE134AAADD5A6BA" modified="2013-06-26" version="1">MRTSRISRDASRIVAASRAQRSLRQTRSAANAPAPSINPPIVKQEAEKGASANSDSELSSAPSDSNSDYEAQPALKKRKRGQGAPVLIKQEASIAALASPKKDTKVKKARRTPAKKIKDSDGSIKIEPPANWEEIYALTREMRNENVAPVDTMGCESLADRKMTPRDQRFQTLVALMLSSQTKDTVTAPVMRGMQERMPGGFNLESVLALEPTQLNAFINKVGFHNLKTKYIKQTAEILRDKWNSDIPDTIEGLVSLPGVGPKMAYLTMSAAWGRTEGIGVDVHVHRITNLWGWHKTQQPEQTRAALESWLPKDKWHDINNLLVGFGQTICLPVGRKCGDCKLADRGLCPSAVVTKRTKVKKEAVVKVEILNNDAIAEEAPNNDGLVKKEASDNDVTVKKEAVVKVEASDNDTVAEEAPSNSFIVKVEAVVKVEASNDAIAEEAPNNSVIVKEEAAVKMEASDNSVTVKEENIVADVDQTKAEDVESAVPDIEDIRRVPRKRTTRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0L5</accession>
    <name>R0J0L5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_167212</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022188.1">
        <property type="nucleotide sequence ID" value="XM_008023997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0L5"/>
    <dbReference type="STRING" id="671987.R0J0L5"/>
    <dbReference type="GeneID" id="19400080"/>
    <dbReference type="eggNOG" id="KOG1720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017787_1_1_1"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120105">
        <property type="term" value="C:mitotic actomyosin contractile ring, intermediate layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030869">
        <property type="term" value="C:RENT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140013">
        <property type="term" value="P:meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051229">
        <property type="term" value="P:meiotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031536">
        <property type="term" value="P:positive regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140429">
        <property type="term" value="P:positive regulation of mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902846">
        <property type="term" value="P:positive regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000073">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="236"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="308"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="401"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA90311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="617" mass="68592" checksum="C595AE8074A6542E" modified="2013-06-26" version="1"> </sequence>
</entry>
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                <person name="Henrissat B."/>
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                <person name="Steffenson B.J."/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="127" mass="14430" checksum="D87EEF3D9D0B30A4" modified="2013-06-26" version="1">MDYMHHRQSSPGPRPASPRRSMQRQRSNSFPIIEALGCTTPEARLILAESRAAVRKRRRRRNQSVEEATRAFNPREALPLTPRRRLSGRSLPAARGALASACLISAHARTHTHTNTHARHYSQRHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2Q4</accession>
    <name>R0J2Q4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_162021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020552.1">
        <property type="nucleotide sequence ID" value="XM_008022361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2Q4"/>
    <dbReference type="STRING" id="671987.R0J2Q4"/>
    <dbReference type="GeneID" id="19398249"/>
    <dbReference type="eggNOG" id="KOG3284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076417_0_1_1"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA91245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="235" mass="26490" checksum="3D2F21416D770A54" modified="2013-06-26" version="1">MYTTRPLAYAPTPYIPRSNLAATINLDEEAKLSTTNAERDLNDSLAEIYSIIITLDAVEKAYLKDSIAEADYTETCSRLMKQYKSNLANETVARAFGDLNQFAREWHMECPRAVERLRVGIPATVEQGPSRPAQQGDFADATLVVNATETFITLLDAIKIGLVEKDTLHPLLVEIIQAVNKVTDVDFESKGKIVQWLITLNQMRASEKLDDEQVREFQFDMDQAYYGFKSTLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3G7</accession>
    <name>R0J3G7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_162214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020689.1">
        <property type="nucleotide sequence ID" value="XM_008022498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3G7"/>
    <dbReference type="STRING" id="671987.R0J3G7"/>
    <dbReference type="GeneID" id="19398303"/>
    <dbReference type="eggNOG" id="ENOG502S3WR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023639_0_0_1"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="245"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="517" mass="54750" checksum="33BA63F89F64EAB3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4I0</accession>
    <name>R0J4I0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_152689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA91621.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
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    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
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    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
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    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="434" mass="48638" checksum="3DED9809653A0270" modified="2013-06-26" version="1">MANKEPTVLIIGAGTFGSSTAYHLSKLYKDPSRITLVDRWDTTSPLEEKHAAAIDTNRIIRTDYDSHLYCNLANEAIHFWFWSIAVQGHFHKTGWTFLERGGDYTRDVAPEELEQYAVTRGVRTERLGKGYFNPEAGWCDAEKATQSFTKVALELGVKRVTGEVQELLLKSDQSGLAGVKLRDGGILTADKVVLAAGAWTSTLMSPLEDALGIPEQDRIERQVTAVGRVSAYYTLNEQDTQGMIDGNLPVVVIGGEVDIIPPSQPNRTLKINDLRSEIVNTVTTPSGHRITAPSPRNQNDVPERLKRESAQVMHQAMPEWTRSKTPSRWRMCYDAVTPSEDWLMCQHPHSQLANLYLSVGGSFHSYKFLPVAGAYMCNVLFGKSNGEEKDRAWQWKSQEWLDKCKGKGKEFGSSRRKLERKELSEYEDGAVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4M5</accession>
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        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">SETTUDRAFT_162302</name>
    </gene>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Exserohilum</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020774.1">
        <property type="nucleotide sequence ID" value="XM_008022583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J4M5"/>
    <dbReference type="STRING" id="671987.R0J4M5"/>
    <dbReference type="GeneID" id="19398345"/>
    <dbReference type="eggNOG" id="KOG0416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_7_1_1"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010637">
        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="174" mass="19716" checksum="039829F4B95400A8" modified="2013-06-26" version="1">MSSPKRRIETDVMNRRLMSDYEVTLVNDNTPFEGGLWKIHVELPDQYPYKSPSIGFVNRIFHPNIDELSGSVCLDVINQTWSPMYDMINIFEVFLPQLLRYPNPTDPLNGEAAALLMREPKSYDAKVKEYVQKYASKDTAEDSDKDDGEDDEMSSVGSYESGDEDGAAGNMDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4N8</accession>
    <name>R0J4N8_EXST2</name>
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        <recommendedName>
            <fullName evidence="9">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_162469</name>
    </gene>
    <organism evidence="10 11">
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        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020920.1">
        <property type="nucleotide sequence ID" value="XM_008022729.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0J4N8"/>
    <dbReference type="GeneID" id="19398402"/>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018931_0_0_1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06228">
        <property type="entry name" value="M14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000155">
        <property type="entry name" value="Zn-dependent exopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353360" description="Peptidase M14 domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="9">
        <location>
            <begin position="125"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA91905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="479" mass="51555" checksum="2AA9E67D6882FDA0" modified="2013-06-26" version="1">MKYALAAALILQGTTVLGSLLPVDFKAPTPAHFLDIVNNGTYDLGCRPKAVAHPDGHYELHALLTEEQIAHLSKEYENSEEVSLHRRDLSKRAADAPIGSGDRFQGGAVTPSGLGTKASGSTISSIMNVNEINSAIKGLVNGYGISTVTLPYKTFNGATQTAGYVGAGTDKTKYKLYLSAGMHARERGGPDQLIYWISDLLAANKAGTGLTYGRKSYTNAQVKSVLAAGIVFFPLVNPDGVTYDQSSGSLWRKNRNTRSGTSGASIGVDINRNFDFLWNYPKYFDPSTSPASNSPRSEAFYGTAAASEPETKNHVSIYDSFPKIRWFMDIHSATGDILYNWGDDETQSTNTQMNFLNSAYDGKRGRIGDTTYKEYMPSADVSNIRSVASKTAAAMAAVGGRSYSSMQSVGLYATSGASDDYAASRVYAKSGANKVHGFTMEFGYATNFYPTLTEFNQNILDTNAGFMDWALAAIAVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4W5</accession>
    <name>R0J4W5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_18437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020083.1">
        <property type="nucleotide sequence ID" value="XM_008021892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J4W5"/>
    <dbReference type="STRING" id="671987.R0J4W5"/>
    <dbReference type="GeneID" id="19402032"/>
    <dbReference type="eggNOG" id="KOG1655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079409_0_0_1"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23653" checksum="556303BB5829C657" modified="2013-06-26" version="1">MNRLFGAKSNAPKPTLNSAISNIDTRIESLDVKLAKLNAELGTYQQKLAKMRDGPGKTAIKQKALKVLQQRKQYEAQRDQLQAQSWNMEQAGMMQDNLKNNMTTIDAMKTTTKELKKQYGKINIDQIDKIQDEMADLLDMGNEIQDAISRSYDVPEDVDESELDAELEALGDEVEFEGIGESSGVPNFMLDDAAPPQFIDEAPVAGGKVKEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4Y6</accession>
    <name>R0J4Y6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_84995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020370.1">
        <property type="nucleotide sequence ID" value="XM_008022179.1"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="290" mass="31463" checksum="BC35F386A8DD15D2" modified="2013-06-26" version="1">MSPPSATEPQQAHDTHLATVASDSTVLNKKELAKAPRPPTFDDPYKEREYLKGRLAAAFRIFGKYGFDEGVAGHITLRDPVDPTTFWVNPFGVAFSLLKASDLILVNGKGEVIDGGEYRMLNTAAYMIHHAVHTARPDVVAAAHSHSIHGRAFCSLGRTLDTISQDSCAFHNDHVLYESFNGVVLAEEEGKNIAQTLGNKKAALLQNHGLLTVGRSVEEAVFWFVSMEKCCQAQLLADAAAAGRGGETVKISDEDAMYTYKAIGSPIAGWFSAKPLFDVIHKESNGDYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLB8</accession>
    <name>R0JLB8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_23301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030045.1">
        <property type="nucleotide sequence ID" value="XM_008031854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JLB8"/>
    <dbReference type="GeneID" id="19402650"/>
    <dbReference type="HOGENOM" id="CLU_2110495_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="115" mass="12875" checksum="AFC49CDDA259952C" modified="2013-06-26" version="1">MQYFRHQATPTDPDFVLINILLVVLCVAIIMLIRLEYREFISAQEEPQAITDTRIPQGEKMVYMRVPPASAAEPHVPRAPRLEPMLCLPPLRPIPLFPSLSLPLPSSSALPSSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0JM47</accession>
    <name>R0JM47_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_165735</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030566.1">
        <property type="nucleotide sequence ID" value="XM_008032375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JM47"/>
    <dbReference type="STRING" id="671987.R0JM47"/>
    <dbReference type="GeneID" id="19399565"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA82323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="299" mass="32773" checksum="6C886754B9BA1C95" modified="2013-06-26" version="1">MANVIANSGHDDMIHDAVLDYYGRRLATCSSDKTIKIFEVEGEKHTLVETLRGHEGAVWSVAWAHPKYGNILASSSYDGKVLIWREQSNSWQKIYEVALHTASVNLVAWAPHEAGCLLACASTDGNVSVLEFKDNNWTHQLFQAHGSGVNSVSWAPAVAPGQVVSASANQTAAARRLVTGGSDCQVKIWEFSPESGSWQNVHILPGGHLDWVRDVAWSPTVLSKSYIASASQDKTVIIWTSSDLRGEWKRTKLDVDAAAWRVSWSLSGNALAVSTGDNRVSLWKERLSGGWECVKTIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0JRK9</accession>
    <name>R0JRK9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_51497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0JRK9"/>
    <dbReference type="GeneID" id="19405182"/>
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    <dbReference type="HOGENOM" id="CLU_001880_0_1_1"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
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    </dbReference>
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        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="247"/>
            <end position="582"/>
        </location>
    </feature>
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        <location>
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            <end position="136"/>
        </location>
    </feature>
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            <end position="671"/>
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            <begin position="1"/>
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            <end position="23"/>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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    </protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030968.1">
        <property type="nucleotide sequence ID" value="XM_008032777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JVL4"/>
    <dbReference type="STRING" id="671987.R0JVL4"/>
    <dbReference type="GeneID" id="19401304"/>
    <dbReference type="eggNOG" id="KOG3893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024220_1_0_1"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA81529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="432" mass="49076" checksum="452432D1377B72B5" modified="2013-06-26" version="1">MSLSSFFRSPVLVFTTSIIFRAVFLMYGLWQDANSPMKYTDIDYYVFTDAARYISRSQPPYARDTYRYTPLLAWLIYPTVWTGKFWFSSGKVLFAIGDVATGWMMFRILKEHKKMTDERALKFASIWLLNPMVATISTRGSSEGLLGVFVTALLWAVLAKQIPLAGFLLGFAVHFKIYPIIYAVSIVLFLDETQFNTAGEANSQSQSLIGQIKAFLNPSRLMLAFYSLLTFASLNLLMYSIYGWPFLEHSYLYHLIRSDHRHNFSPYSTILYLSSSPKPSGLHSAPPSFGLERLAFLPQLLLSAVFIPLALSKKDLPDTMLAQTFAFVTFNKVCTSQYFLWYMMFLPYYLPQSTLLQSPSIGVFALLSWIAGQAAWLFQGFQLEFNGNSTFVPALWIATILFFIINVGILSVIINDTKQKPVQAVVSQKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JVM8</accession>
    <name>R0JVM8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_91865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027520.1">
        <property type="nucleotide sequence ID" value="XM_008029329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JVM8"/>
    <dbReference type="STRING" id="671987.R0JVM8"/>
    <dbReference type="GeneID" id="19405938"/>
    <dbReference type="eggNOG" id="ENOG502RXKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048316_2_0_1"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="285" mass="31253" checksum="78A0EE5539272301" modified="2013-06-26" version="1">MVLLAMTPGIARAVARAEQLAPDDYAGLHRDDEPALADPQPGNPISHRQLIGLSKLLKKHLPRPCPETTIEETAIEETTQDAEEEAIPRTLAALLANTTLYTPPPPPKPPKTPEYEALMARLRAEQEALSYDRMLHPPPTRETFSQRFPRAPAPFSIGAAQAASDEDDVSYEEVHRQIILIINILVSIVCVAIFIWVAARHWSVGSRLGLSMGGALAIAVAEVAVYSGYVRKVREAKRLEKKKPEIKEIVKTWVLGEPGQAAAAEATGCKDKDGDGVRFRKGKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXZ8</accession>
    <name>R0JXZ8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_100919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031638.1">
        <property type="nucleotide sequence ID" value="XM_008033447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXZ8"/>
    <dbReference type="STRING" id="671987.R0JXZ8"/>
    <dbReference type="GeneID" id="19394820"/>
    <dbReference type="eggNOG" id="ENOG502S8FX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031555_3_1_1"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA81112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="43345" checksum="F814A6B1651F244A" modified="2013-06-26" version="1">MSMVTHEIDPFADTIVILKNPCKNFAPWDETLVSSQIEVPEPEEKQLINAQTIELAEPASGPTQSEDDEIHYLVSSRHLMLASPWFRRTLTKEEFVESSKNASDGRYHIQANDWDEEALLILLNIFHVRTRQVPAAVSLEMLAKIAVLVDYYELENAEVMERDVRDWTANVRRSVAIPSSYCRDLMLWICISRVFHMSEEFEKATAVAIKGSEGWIQTLDLPIHQEITSSIDCSRCNALEHVVSELHRLLGVYRDFNYCCPHNPSYSFQCGAFLFGALMKYMERWGCLWPRPENPFMGISLNKICNRSGMTKNTKWWVKSDCYDYYRRHDHEKFEVHSCSLNVKIDEVVQDTMAKVRGLKLQDFRDNSQVSFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0JY01</accession>
    <name>R0JY01_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_33954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029404.1">
        <property type="nucleotide sequence ID" value="XM_008031213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JY01"/>
    <dbReference type="STRING" id="671987.R0JY01"/>
    <dbReference type="GeneID" id="19403835"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="342" mass="37333" checksum="E3CDA8807AE3724B" modified="2013-06-26" version="1">MASQSPLKIILGTHMIGDTNKDPGTVRFDKKEDVQALLDAFHGRGYSHLDTARDYSPGDQGASESRLGRASAVSRFTVHTKVHSTSPGDHEPAKLALSISQSLRDLQAPSVETMFLHFPDRQTPFEDTAKAMNDALVQGKFRGFGLSNYSAAEVYRFLEICEEHGYAKPSVYEGHYNAIARGCEKELFPLLRKHGMSFYCYSTSPAAGGLFSEHSETSGRWQKDVSKPQQASTQPGLTMQNFIGKPYNIMYGKPPVHAAVAMILELAEEHGMNGHAAAIRWTAFHSNLDGKYGDGIIFGVSSVGQLNKTLDALEAGPLPAELADAISEVYEVVEGAEPPYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZ11</accession>
    <name>R0JZ11_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_165947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030933.1">
        <property type="nucleotide sequence ID" value="XM_008032742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZ11"/>
    <dbReference type="STRING" id="671987.R0JZ11"/>
    <dbReference type="GeneID" id="19399639"/>
    <dbReference type="eggNOG" id="KOG3801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120076_0_0_1"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
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        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA81477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="113" mass="13267" checksum="BDB5F5D59E126E4A" modified="2013-06-26" version="1">MSLAQATKGNMAYQVRSLYRSLLRQSNQFAAYNFREYAKRRTRDAFRDNKSITEERTIQELVQKGLSELQMLKRQTVISQFYQIDRLVVEGGKEGKQKGDRSDIVRVKDQGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZ72</accession>
    <name>R0JZ72_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_161392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026172.1">
        <property type="nucleotide sequence ID" value="XM_008027981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZ72"/>
    <dbReference type="STRING" id="671987.R0JZ72"/>
    <dbReference type="GeneID" id="19398148"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090201_3_1_1"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF23">
        <property type="entry name" value="JUVENILE HORMONE ACID O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="76"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="218" mass="23251" checksum="28407EA7F0D705A9" modified="2013-06-26" version="1">MAASDTQTSDPLLARAFAASSPSESRSLYDQWASTYDTSMSAHNFTAPQLVAAAVARGLKTNHIAPSAPLSGLKILDAGCGTGLVGIALSQLGATAIVGVDFSEGMLAVAQNTRAYNELRIADLTQRLEFGDATFDALTCCGVFTHGHLGPKPLEEFVRVVKCGGVVVATVLESFWNEQGFERVMGMLEAEAKVDVVEKKLWAYREGVEGRVLVLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0L3</accession>
    <name>R0K0L3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_23241</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="10"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030036.1">
        <property type="nucleotide sequence ID" value="XM_008031845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0L3"/>
    <dbReference type="STRING" id="671987.R0K0L3"/>
    <dbReference type="GeneID" id="19402641"/>
    <dbReference type="eggNOG" id="ENOG502QQE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_2_0_1"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF26">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA81992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="282" mass="30761" checksum="874C56CC5D6322EA" modified="2013-06-26" version="1">MGFALGTKMANGQCKTQQDYEADFDAIKFQSDATMVRGYSAADCDMAKHALAAAKAKGFKVMLGIWPDVEASFKRDLAAVIAVASSYPGTLYAVTVGSETLYRRNFTGAELADKISTVKAQLPEGVKVGTADTWNRIADGTANAVLGVSDILLINAFAFWQGAARNDAPRILFDDMAQAVRRVESELKGDKDKIPEIWGGETGWPTSSDSHYEDAVGGLDNARYYYQHGYCGIVNWGYNAFYFEAFDELWKPMSVGKNGHAADETTWGAMTADRKAKFSLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0N4</accession>
    <name>R0K0N4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_23256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="11"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA82007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="340" mass="38012" checksum="213E9FA0984DE3E6" modified="2013-06-26" version="1">MATLCTLVAVWRLAIRLQINRRLTLSDWLMAGGVVLNFLGCLPYAVLAAKGGQGRLMSDPWWLIPGRMSNELHMIFITQCLNVYAMFLVKASICAYLMALDFGRSYRVLIWTSVVIVVLCNFVMMLILHFAYCRPYYSRWDFAVQGECWPEAVSDVTAYVQIASNIITDLIYAAAPIVYLRNVKLSTQTQWGVRTVFLLALVGTGLSIAKIPITAKFLRSEELMWDAIDLSICSINEVCVGIIVANLPPLRKTILGVFSRILPESFATAIGVSRKHNSQFNAVSLQYTSKGRTKLQDDADGESERCILKLGERQQHWNIMKTTHVSICDEAAGGKETITV</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">SETTUDRAFT_65791</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83319.1"/>
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    <dbReference type="AlphaFoldDB" id="R0K0V7"/>
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    <dbReference type="eggNOG" id="ENOG502SSCW">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718776_0_0_1"/>
    <dbReference type="OrthoDB" id="3933088at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="384" mass="41713" checksum="C37A70C8B0644E7B" modified="2013-06-26" version="1" fragment="single">MSDYEDDYDDGDADFFYVEDEYMAADDLAEHAVASPPPATCGDEDMEDDWDRFDYFNDLEYASDGYDDTRFQALDVKGVKTGIKRKRAVGGRSRRKNVPQVDATAHTEPSAPGHSPIVWRSHADRGLKPKMLDDNAQPYALFKDWREKLTETPDWAKGSPPNSPGASSLPSDKEKGDMAFVTKPASPPYDDDDEDEDDKEGDEDDMSTQGHGISQEALLAALQRQLAAAGGPLSGMDPQQLLEFATRMAADKDAGDDIAGEMADAMLEGEDEEDDGEAEEKLLSWVAQQRNSTKETADDESTSADATPSSKQPPTPPSSNHNRSTATSQTSTTTDSKTTTSSRKRKADNEPAAKGATHAVKKRNTRSFDAPTASSQAKAALPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1J0</accession>
    <name>R0K1J0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_142410</name>
    </gene>
    <organism evidence="12 13">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032354.1"/>
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    <dbReference type="STRING" id="671987.R0K1J0"/>
    <dbReference type="GeneID" id="19396672"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003632">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028395.1">
        <property type="nucleotide sequence ID" value="XM_008030204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2W3"/>
    <dbReference type="SMR" id="R0K2W3"/>
    <dbReference type="STRING" id="671987.R0K2W3"/>
    <dbReference type="GeneID" id="19399083"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="671" mass="72827" checksum="7C9C9CE4F9E73D9D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0K356</accession>
    <name>R0K356_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_92221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028444.1">
        <property type="nucleotide sequence ID" value="XM_008030253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K356"/>
    <dbReference type="STRING" id="671987.R0K356"/>
    <dbReference type="GeneID" id="19405962"/>
    <dbReference type="eggNOG" id="ENOG502RZN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1115659_0_0_1"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28210" checksum="ACFD104E939585F1" modified="2013-06-26" version="1">MAPPKRALFSLNLDTDADHVYQKVEDHSKSGDDRVRVLETRGPTHGHTDLSFVTKPFEKTVNRAVNDVIDGTGKRVASKQGEITYSTTTNRRSTHQTPLRIVVGCDDAGVGYKNTIIKDLEGDARVASVTDVGVPSNTDKTAYPHVAVNAAQLVASGQADRALLICGTGLGVAIAANKVPGIRAVTAHDSFSVERAILSNDAQVLCMGERVVGIELARRLVREWLGYRFDQGSASAKKVEAIMEHEKKNYAGLVKDQAGQSC</sequence>
</entry>
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            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">SETTUDRAFT_109438</name>
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        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024778.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K377"/>
    <dbReference type="STRING" id="671987.R0K377"/>
    <dbReference type="GeneID" id="19395364"/>
    <dbReference type="eggNOG" id="ENOG502SQ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_4_1_1"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
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    </dbReference>
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        <property type="entry name" value="HET"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="55"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="284" mass="32086" checksum="D74F7E3597C2A4F8" modified="2013-06-26" version="1" fragment="single">MRLINFNRLKAWLHTCLTDHVHQEPEAASSIANLRVIDCHHSGRVVVPAPTECEYVALSYVWGVQGPGNFEDADGFPPTVMDAVIATKKLGYRYLWVDRYCIDQSDENDQHNQIKQMDLIYSHAKVTIIAAAGKDPSYGLPGVSRNSFEKVYTEPLNSNWALKTELPPLFSCFITSNWFLRAWTLQEGILSKRKLCFTDYGVLFLCNSNTTGNTCLECESFKDHAKKYKQLSIPMESAMNGIIPNNILEAQTSEEKLSIIKVFLDAYSQRELTYESDSLNALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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    <name>R0K3H8_EXST2</name>
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        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
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    <gene>
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    <organism evidence="5 6">
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="19404789"/>
    <dbReference type="eggNOG" id="ENOG502SK68">
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    <dbReference type="OrthoDB" id="5361565at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353957" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="45"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA84119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="501" mass="55074" checksum="8CC922828BDCCF68" modified="2013-06-26" version="1">MASSLLYLSATVLLAQSTVALNCSKPPVYVDIHKRAVHDSPVFQYGSFIGLGTPAQNQSLWPSLQQNVTSFASTEYCKGNTTLKNCDTSTGGFYSPQDSTSFEQKDGFKTLDAAQDNLLGFFGQETVRLYTHYFETDAASQTLVSNTTIQVAESGSITPGRVGVGSSSTLLRDLVAQNIITGSTYSLYIGQGFDRAGGVVNGSNVFGGYDSGRFTGDAHQYPMNIANTNPMSVRVKDIIITKTSDNSNTSLFDNTVFTDMQSRPDAFEAQITTEQFPFSLPYQITQNLIKQLGAEQDNTWGDNSLKLKNSFDGTLSIVLEDGFTVTLPPEVLMNASNITPVQDRAKSADTPFYLGTAFLGQVYLMADYDSNTFYLAEAIQKNNMVMPVTFCPRTTPVAYQRPKQSEWARQGLAGAVVGGVIGGMGIIAASYCLWVAWMRKKDKRRLQRELQRNSQRKLEQLDIEDGRPPPPKFDPPPQQQQQSVNAAKAMFWRKNKPGTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5G7</accession>
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    <protein>
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            <fullName evidence="11">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_130076</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024303.1">
        <property type="nucleotide sequence ID" value="XM_008026112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K5G7"/>
    <dbReference type="STRING" id="671987.R0K5G7"/>
    <dbReference type="GeneID" id="19396102"/>
    <dbReference type="HOGENOM" id="CLU_408295_0_0_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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            <end position="461"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="485"/>
            <end position="498"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA88283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="66968" checksum="1F48F7241EDDD09B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0K629</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_163743</name>
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    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="88410at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724:SF2">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="57" mass="6229" checksum="8C0476E1B1E4A712" modified="2013-06-26" version="1">MCKKASCDSCHKTTWWGCGNHIAGVMESVPSDQWCTCGPRIEKEGHQYPPMGTLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0K685</accession>
    <name>R0K685_EXST2</name>
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        <recommendedName>
            <fullName evidence="7">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_91286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027521.1">
        <property type="nucleotide sequence ID" value="XM_008029330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K685"/>
    <dbReference type="STRING" id="671987.R0K685"/>
    <dbReference type="GeneID" id="19405890"/>
    <dbReference type="eggNOG" id="KOG0212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007740_0_0_1"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="606"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="967" mass="106771" checksum="DE342946D1092ED3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6J4</accession>
    <name>R0K6J4_EXST2</name>
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        <recommendedName>
            <fullName evidence="7">DWNN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_137559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EOA85139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0K6J4"/>
    <dbReference type="GeneID" id="19396419"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
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            <end position="424"/>
        </location>
    </feature>
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        <location>
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            <end position="573"/>
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    </feature>
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        <location>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="392"/>
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    </feature>
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        <location>
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            <end position="548"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="573" mass="63148" checksum="F1DC13EACA6C1CC1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0K743</accession>
    <name>R0K743_EXST2</name>
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            <fullName evidence="3">glutamate--tRNA ligase</fullName>
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            <fullName evidence="12">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="17" type="ORF">SETTUDRAFT_172617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84097.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_008028493.1">
        <property type="nucleotide sequence ID" value="XM_008030302.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0K743"/>
    <dbReference type="GeneID" id="19401196"/>
    <dbReference type="eggNOG" id="KOG1147">
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    </dbReference>
    <dbReference type="eggNOG" id="KOG4575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002839_0_0_1"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000005">
        <property type="entry name" value="SH3 domain protein (Cyk3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="EOA84407.1"/>
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        <source>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023064.1">
        <property type="nucleotide sequence ID" value="XM_008024873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8F8"/>
    <dbReference type="STRING" id="671987.R0K8F8"/>
    <dbReference type="GeneID" id="19397959"/>
    <dbReference type="eggNOG" id="KOG2414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_2_0_1"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="136"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="363" mass="40076" checksum="DEA830947B171E6F" modified="2013-06-26" version="1">MVNVYVYKIRWEPEDRPFLMVIRPQVQATADEDDAVVANTTFLVPRFEEARARMLSMPFENDIHVVAYEEHWNYYTTLSLSEIWGDTLSPKLMVDDEMRDFIQRGLASNGFTVAGLAGQVEATRQVKTAREIGILKAVNTGTAQAIRAMRQCLYPGVTENQVKLVLDDTLRAAGLDPFFDIVEFGKSAALPHGGYDVTRKLEAGMFVLIDVGAKLYGYSSDVSRTFYPPFEAAPQASEHNQTEQLHVWQLVLDAQKAAVMAMVPGATAASVDIAARDVIQAAGYGPYFTHRLGHGIGIKAHESPYLNKGNLATTLRPGMVFTAEPGVYLMDQFGVRHEDVLVVKEDGEAENISGGFAKGPWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9L7</accession>
    <name>R0K9L7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_159257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022630.1">
        <property type="nucleotide sequence ID" value="XM_008024439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9L7"/>
    <dbReference type="STRING" id="671987.R0K9L7"/>
    <dbReference type="GeneID" id="19397916"/>
    <dbReference type="eggNOG" id="ENOG502QV1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_13_1_1"/>
    <dbReference type="OrthoDB" id="3686395at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="488" mass="55753" checksum="F50C78C0ADE20340" modified="2013-06-26" version="1">MTLHDVGMLQRCDVDQFYKYTSGRWLWNEKHQLARRYVKFDLPELLQVSAQATGARSCDKIEKLPEGNFSKVFLITMNNGRELIAKLPNPNAGRPHFTTASEAATMDYVRNVLGIPAPRVYGWSSSTDNLVGAEYILMERSRGERLEVIRTLVGYEKAFVCVNLPMYGSLYYAKDLPSPSPNQFLDPANSVHKDSVQVDRGPWLSLEEFIHSRAARELACVDKFSSYLGQQGLFRGPNQYRPSRALKVRVLGDYLKIATQILPNDFNLSKPTLWYPDLHSDNIFVGPSQPTRILDIVDWQAVNMSPLFLQARHPSLIEFEGPIPQGFEPIALPDNFDDMSEEAQHQAKNLRAAQSLYKVYEILMLRQCPDIAHALHFRDTLPGQITGLASSNFSDGEPVLQGMLIRLQNEWETYVTSSTPCPLSFTPDDRMQQQRVELMHEVSAEIGAYQGWDGWVNHSNYPVYKERLARCRENFLHRYAKTDEERSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9Q0</accession>
    <name>R0K9Q0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_117439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027479.1">
        <property type="nucleotide sequence ID" value="XM_008029288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9Q0"/>
    <dbReference type="STRING" id="671987.R0K9Q0"/>
    <dbReference type="GeneID" id="19395724"/>
    <dbReference type="eggNOG" id="ENOG502QT79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266976_0_0_1"/>
    <dbReference type="OrthoDB" id="5284003at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="623"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA84982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1245" mass="140738" checksum="189DF57905200BA4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA27</accession>
    <name>R0KA27_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_26158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022419.1">
        <property type="nucleotide sequence ID" value="XM_008024228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KA27"/>
    <dbReference type="STRING" id="671987.R0KA27"/>
    <dbReference type="GeneID" id="19402984"/>
    <dbReference type="eggNOG" id="KOG4603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063266_3_1_1"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="6">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="211" mass="23459" checksum="151CF10E7739E93B" modified="2013-06-26" version="1">MAPRKKTEEKASASEAADMVLQYLRKQNRPYSAIDVSANLHNKVTKASAAKILKDLHEQKLIEGRAAGKQIVYHALQDAADICTTEQLAALDATILHLRSQTATLNATAKTLRSALSALNSTLSTAELVAGVDALEREKVEIEGRLDGLRKGKGRMITPAERKAIEKEWRARASVARKREKIAKDMWKIIADYLPDDEAREEHREMFDLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAL9</accession>
    <name>R0KAL9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_154863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027723.1">
        <property type="nucleotide sequence ID" value="XM_008029532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAL9"/>
    <dbReference type="STRING" id="671987.R0KAL9"/>
    <dbReference type="GeneID" id="19397448"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067602_0_1_1"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA85292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32706" checksum="6437108CF5E52349" modified="2013-06-26" version="1">MASVQQQPNGNGTAVRPPQSEHEGSKENIFLFIPNLIGYSRVFLALTSLYYMPLHPRTCTLLYSISCLLDALDGYAARKYEQSTKFGAVLDMVTDRCTTTCLLVFLAQAFPRWSIVFQLLISLDLASHYMHMYATLSMGGSSRSHKNVDESRNWLLKQYYSNNKVLFTLCAMNEIFFIALYLLSFSSPYLSPTLFSDPKNPSSLKPGSPAAPEPSLFFASPFSAAAMEMARANKMDSTVPWIFMVVSLPFMLIKQWINGVQMKTASQWLAEGDREARRLAGLPRKGSAKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBW1</accession>
    <name>R0KBW1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_29034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908648">
        <property type="protein sequence ID" value="EOA85702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026628.1">
        <property type="nucleotide sequence ID" value="XM_008028437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBW1"/>
    <dbReference type="STRING" id="671987.R0KBW1"/>
    <dbReference type="GeneID" id="19403306"/>
    <dbReference type="eggNOG" id="ENOG502SE9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018936_0_0_1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="91288" checksum="2B0E18A798D87797" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KD28</accession>
    <name>R0KD28_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_19807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024956.1">
        <property type="nucleotide sequence ID" value="XM_008026765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KD28"/>
    <dbReference type="STRING" id="671987.R0KD28"/>
    <dbReference type="GeneID" id="19402243"/>
    <dbReference type="eggNOG" id="KOG3332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034979_0_0_1"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354098" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA87284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="279" mass="31079" checksum="7A4FCFC07EC8CCB9" modified="2013-06-26" version="1">MNWTVWASVPVLVFAFWMYASALASTFPTLENKRIVLLIAHPDDEAMFFAPALLALTRPERGNHVKILCLSSGDADGLGEVRKKELVKSGLQLGIGSKQDILVIEDKNFPDSMTATWPPRLIANVLSTAFAPNMSSTSPKDAPQATVDAIITFDAHGISGHPNHKSLHAGAHGFLKALMHRHSGWECPIKLYTLTTTSIFRKYLSLLDAPATLIGAIVRKKELGRYPTPLLFVSSPARYRTAQKAMTTAHESQMRWFRWGWITLSRYMVLNDLKLEKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDL1</accession>
    <name>R0KDL1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_166850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021666.1">
        <property type="nucleotide sequence ID" value="XM_008023475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDL1"/>
    <dbReference type="STRING" id="671987.R0KDL1"/>
    <dbReference type="GeneID" id="19399951"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_0_1"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA90983.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="582" mass="64629" checksum="2567FA8C72D4A050" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KE85</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
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        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="238"/>
        </location>
    </feature>
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            <end position="52"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="243" mass="26587" checksum="C0936F31B3A24CB2" modified="2013-06-26" version="1">MARARPLARSTWSLQRCAAPPFAPRQCPQCSRSFASSPPYRQSAKRQMQTATAYRPSSLYPEPPPRNAGVPDTSIAGGATAPRSTTPPAPPQERDAASQSELPKATIPEGEAQKPQQTASPSKPLRPRRYNFGPRKATIKLSPSAVAHLRELLELPEPKLIRIGTKAKGCSGLAYHLEYVDKPSPLDEQVEQDGAKVLIDNKALLNIIGSEMDWLEDKLNERFIFKNPNITEQCGCGESFSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEE3</accession>
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        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
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    </protein>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA87684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024585.1">
        <property type="nucleotide sequence ID" value="XM_008026394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEE3"/>
    <dbReference type="STRING" id="671987.R0KEE3"/>
    <dbReference type="GeneID" id="19398093"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000011">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF15">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="43"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA87684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="483" mass="52146" checksum="47D836F8F2E4D4A7" modified="2013-06-26" version="1">MAALPAPTPITEWPDYNTNPAGGDPMTTDLNAPYDKGDLCWMQITPAIGFLYAGMHRRKAALTMIFQSLFCACAAGIQFWVYGYSLYQSHTTGPFIGDLSKAGLHNTLAYPSLANSDIPDIMYACFGFTFVTATAMILAGAMLERGRLGPSMLFLLCWTTFVYYILAYAEWNPSGWLYNLGVLDFAGSGPVHIASGFSALAWAVMLGPRVDPHNESHHPRIPHFKPHSPFLVGLGTIFIWFGWFAFNGASTANISIRSIYIVCNTNLAACGGGVAWVLLEYLFTRKFSIIGFCSGIISGLVGITPACGYIPIETSALVGALTSCSTFFVVKYKHLLRVDEGLDIFAIHGVGGFVGDILTGFFAAKNIPALDGVSNTYEGGWWNHNWKQMGYQLAAATTCATWSFVISVILLFIINKIPGCHIRATEDDELKGLDYKYFSDADGDIVVLNGYGATTPGATSLGLPSGGSAASHQDIPVEAAKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KF81</accession>
    <name>R0KF81_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_88610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008027181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KF81"/>
    <dbReference type="GeneID" id="19405718"/>
    <dbReference type="eggNOG" id="ENOG502QXCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
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        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34580" checksum="44FBE80766A1877E" modified="2013-06-26" version="1">MTRPLSSTPISIVPSASELGSGLLGQRNLEIAIRALARDGLVVLEDMVEHAVLDRLNQKMVQDAYQLQARKDSPFNYNKGNIQQDPPMTADWFSSDIYTNPIVIQVTSTALGPKPSLRFVSGNTALPPTEASPPVSQPTHNDADFDHPSIPFALVVNVPLVTMTPENGSTEVWLGTHNNTTIADQEGEHGDRASGRIKKHLLDARGEIRPPSQPVVNKGSIIIRDLRLWHGGKPNLTSEPRVMLAMIHFAPWYRNAMEVEFAEELAERLSPAKTGLDVAAKFIAAEHLLKNYMNRSFGNAYDFDQRDKIEGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFA2</accession>
    <name>R0KFA2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_162219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020695.1">
        <property type="nucleotide sequence ID" value="XM_008022504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFA2"/>
    <dbReference type="STRING" id="671987.R0KFA2"/>
    <dbReference type="GeneID" id="19398306"/>
    <dbReference type="eggNOG" id="ENOG502QR2R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010712_1_0_1"/>
    <dbReference type="OrthoDB" id="2113314at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
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        <property type="entry name" value="CBM87_Agd3"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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</entry>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA86952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="122" mass="13284" checksum="30945566DABB264C" modified="2013-06-26" version="1">MSAIGSLVFCTDCGNLLDGSVGQQQNVVLTCGVCGAHNKDTSSKTVVTVSKPTAFPSTLRAKRSEVQTISEEDVQTTSVINHPCEKCGKEQVRYYTQQLRSADEGTTVFYECDCGHKWNTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0KG03</accession>
    <name>R0KG03_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_108159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024270.1">
        <property type="nucleotide sequence ID" value="XM_008026079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KG03"/>
    <dbReference type="GeneID" id="19395281"/>
    <dbReference type="eggNOG" id="ENOG502SSTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821332_0_0_1"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="338" mass="37066" checksum="D8E07A9F8696EBDD" modified="2013-06-26" version="1">MEIPGYNELVYYSTPPNSYIGTAIFLSYIVAAVYATTSTTYSLYSQYSSIFNTPAAKEDTTRNAALAARARHVKIYAFIASLSFATLAYHMLMFLITHYLEWSGKKSSSLGAVNIEQLKSWMLESTLFHDFGQELVQNAPNAAWTEAAILATWFWNIYMAQKARARNYDASTMRNYILLSQTLPISFAVSLFLIQLHLSSPDIAPAQTSKDPAKPVAAPQRRKPIASLQIPNILVNASLLALPPLRSNSIFMVLLLVTRAVLLVPHWALMSLKDSDVVKCITISGGFVVANMAMMKKDFSPAALRGSLEDGGHAIKALGWDTVLGALVYIVLGWGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGK9</accession>
    <name>R0KGK9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="8">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_162540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="8"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020981.1">
        <property type="nucleotide sequence ID" value="XM_008022790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGK9"/>
    <dbReference type="STRING" id="671987.R0KGK9"/>
    <dbReference type="MEROPS" id="C01.085"/>
    <dbReference type="GeneID" id="19398426"/>
    <dbReference type="eggNOG" id="KOG4128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_1"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
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                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Barry K."/>
                <person name="Schmutz J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2832805_0_0_1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
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</entry>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <location>
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            <end position="51"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="118" mass="13210" checksum="2E29A037D065FCC1" modified="2013-06-26" version="1">MAYQQLPKLQQNVQVEPLDERYSPPPLAHHSMEDVRSFEYEQPSPQSSEPQSIRHKAHWSSSTHTTAVTSETSSQQSSRKPSRARTWVFEMMAIAVALGAVGSIIGVVFRYNGQALPD</sequence>
</entry>
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    <accession>R0KJ15</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
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    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
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    <dbReference type="STRING" id="671987.R0KJ15"/>
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    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
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        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_tran_Xtn"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA"/>
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    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="620" mass="69173" checksum="4F9A1C03FA74514C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
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        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
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    </comment>
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        <subcellularLocation>
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    </comment>
    <comment type="similarity">
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ascomycota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKC7"/>
    <dbReference type="GeneID" id="19398028"/>
    <dbReference type="HOGENOM" id="CLU_2759414_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354247" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7626" checksum="3D8C29CCA9863A6C" modified="2013-06-26" version="1">MTGTTITALYCCSLSLSLSWHNNNNDDDNDNVHASLTLRFTLCSSFFTIPIQPNPAQPDPADPTNLDTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KL79</accession>
    <name>R0KL79_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="6" type="ORF">SETTUDRAFT_167634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022802.1">
        <property type="nucleotide sequence ID" value="XM_008024611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KL79"/>
    <dbReference type="STRING" id="671987.R0KL79"/>
    <dbReference type="GeneID" id="19400252"/>
    <dbReference type="eggNOG" id="KOG3350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074410_1_0_1"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA89914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="240" mass="27407" checksum="992E6A950536289B" modified="2013-06-26" version="1">MAPLIEDDDIPQLSGDALAALQQFYGERDERAKQFQELKAKAEDDFEGKLSMEAFTEDWNASQFWYSDETATVLAKQLLDGATDETRIAVVSAPSAFIQLKNLINSGEVKCRPQIKLLEFDDRFAVFKEFVPYDFEKTFQLPPELKGSFDAIICDPPFLSQDCQTKAALTVRWLAKSWTQESLRLIVCTGERMESLVTEKLYGKAGVKTTDYEIMHTKGLSNEFRCYANFECEAWKWNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRB9</accession>
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        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_167256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022224.1">
        <property type="nucleotide sequence ID" value="XM_008024033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KRB9"/>
    <dbReference type="STRING" id="671987.R0KRB9"/>
    <dbReference type="GeneID" id="19400098"/>
    <dbReference type="eggNOG" id="ENOG502QQN3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_4_1_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="133"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="349" mass="38214" checksum="876F3D90FD660F68" modified="2013-06-26" version="1">MAITNTSSTVQGIFSLHVITAGCSIILFLAAIALFARQVTGGPARPRMFMPFWQSTGKGHSAAATHFFVISGLFCLLLAYSTQSAIVALQSRFPGSSFAITPAYSYPRYTSAYGYNPDIPYAKIISILSFLYQCACILLQACIVGGIWILANHMHSNGTHIPEPGFLSLVLNAFWLVAIVGLGLASWIVGLARRGSGNSASAYPEMVQRDYTARTLYVTYVAVVITASMSVTIEAVLCWIGMRKHGRVGNRFQAPLTRLIALVTPLVWIRNCFSIAQIVIIYYNVTNWSRTTNQALAFLFIIFGELCDLGILAVLLLGAWSFGRRDEVPEGAVKEVRYSESVVRDDIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSP1</accession>
    <name>R0KSP1_EXST2</name>
    <protein>
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        </submittedName>
    </protein>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="R0KSP1"/>
    <dbReference type="STRING" id="671987.R0KSP1"/>
    <dbReference type="GeneID" id="19394877"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_32_1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
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    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
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    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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            <end position="85"/>
        </location>
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    </feature>
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            <end position="212"/>
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    <feature type="repeat" description="WD" evidence="3">
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            <begin position="423"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="463" mass="49196" checksum="8AE90951A65153FF" modified="2013-06-26" version="1" fragment="single">MLEGHSDYVNAVAFSHDSTRLASASDDRTVKIWDASSSACLQTLKGHSGSVSSVAFSHNLMRLASASYDRTVKIWDASSGACLQTLEGHTSRVNSVAFSHDSTRLASASYDRTVKIWDTSSSACLQTLKGHSGSVSSVAFSHDSTRLASASYDRTVKIWDASSGACLQTLEGYHSGYVSSVAFSHDSTRLASASYDRTVKIWDASSSACLQTLEGHSDYVNAVAFSHDSTRLASASSDNTVKIWDASSSACLQTLEGHSDYVNAVAFSHDSTRLASASDDRTVKIWDASSSACLQMLEGHSDYINAVAFSHDSTRLASASYDSTVKIWDASSGACLQTLKGHSGSVSSIAFSHDSTRLASASYDRTVKIWDTSSSVCLQTLEGHTSRVNSVAFSYDSTRLASASSDNTVKIWDASSGACLQTLKGHSGSVSSVAFSHDSTRLASASYDRTVKIWDASSGACLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSR4</accession>
    <name>R0KSR4_EXST2</name>
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            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="6 7">
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
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                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Han J."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Schoch C.L."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">28A</strain>
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        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
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    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
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        <location>
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            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005145278" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA91287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="546" mass="59361" checksum="B7F90933684C398C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0KVC0</accession>
    <name>R0KVC0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_113614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020790.1">
        <property type="nucleotide sequence ID" value="XM_008022599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KVC0"/>
    <dbReference type="STRING" id="671987.R0KVC0"/>
    <dbReference type="GeneID" id="19395605"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013153028" evidence="8">
        <location>
            <begin position="16"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="150"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA91687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="396" mass="40562" checksum="5BE531166DE91C34" modified="2013-06-26" version="1">MQLSLLLALLPAVLALPAPVIVPRAGTPIPGRYIVKVKNENVENLINNALKLLTKDPQHVYKFGGFGGFSADITDDIVNRLRNLPGVDYIEQDAVIKANLGEFDEAPLEKKAYVSQSGAPWGLSRISSQSRGGTTYTYDSTAGAGTCAYVIDTGIYTSHPEFEGRATFLANYAGDGSNTDGNGHGTHCAGTIGSKSYGVAKKTQLYAVKVLGADGSGTNSGVIAGINFVANDVKTRSCPKGAVANMSLGGSRSTAVNSAAANAVTAGVFMAVAAGNDGRDAANSSPASEPTVFTVGATDSSDRIASFSNYGSVVDILAPGVSILSTWIGGRTNTISGTSMATPHVAGLGAYLLSLEGARSPAALSSRIQSLSLKNKITGVPSSTVNYLAFNGNPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0KWH2</accession>
    <name>R0KWH2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_162584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021011.1">
        <property type="nucleotide sequence ID" value="XM_008022820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KWH2"/>
    <dbReference type="STRING" id="671987.R0KWH2"/>
    <dbReference type="GeneID" id="19398443"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007860_1_0_1"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="512"/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Salamov A.A."/>
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                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030414.1">
        <property type="nucleotide sequence ID" value="XM_008032223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9E1"/>
    <dbReference type="STRING" id="671987.R0I9E1"/>
    <dbReference type="GeneID" id="19399517"/>
    <dbReference type="eggNOG" id="KOG2646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037994_1_0_1"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="258"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA82095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="422" mass="47404" checksum="8896A02C4288C0D5" modified="2013-06-26" version="1">MSVCRPARCLFTKAVSTTLPKPPPQRTFHASAPRQARKKRPHYPSIKADELKLLNQAAEAEYPKYDTSETALLEKKYTPSQIAAIQAAESTIDARDVLTQGQRRTDFWRLNYEDDLAEVDPVTDRPEKLTSDNIEGPKTFRVANEVERDENISRIASENLAKMFPDGIPDDDEGLPGAMQAAITQATLDPRATYTSNNPAALQALGDERYSVIAPDLPRLENRMARQTRRLATEEQEDPRQKRLLQYLGWNKEKLRGIKVKTLVVHGVTNQTRMGKIRSLYYLTIAGNQNGLLGVGEGKSVEPDEGRKQSVMSAIRNMRPVPRYENRTTFGDLEKKVGATKVQLFSRPPGFGLRVQHLIFELARAAGLQDLSAKTPRSRNKMNVIKATWEALTSQKLPDEIARARGKKLVDVRKVYYGGSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAG4</accession>
    <name>R0IAG4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_35045</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030140.1">
        <property type="nucleotide sequence ID" value="XM_008031949.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IAG4"/>
    <dbReference type="GeneID" id="19403974"/>
    <dbReference type="eggNOG" id="KOG4645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001999_2_0_1"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028319.1">
        <property type="nucleotide sequence ID" value="XM_008030128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IFK0"/>
    <dbReference type="STRING" id="671987.R0IFK0"/>
    <dbReference type="GeneID" id="19397489"/>
    <dbReference type="eggNOG" id="ENOG502RYB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_1_1"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004352944" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA83841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="292" mass="30738" checksum="3A9819183081096F" modified="2013-06-26" version="1">MKASAVFSAAASLFATVSAHGAVDKYIVGDTSYAGWLPYNSAAGQKSIQRQYPSFDPLYIKDLSTVNIRCNNAGVLGTGLTGTIAAGATLKTHWAQWTHRPTSFLVYMAKCPGSCNSWDGSGKVWFKIYEQGLISGTENAGIWAGDAILDTLYATVTIPATLVAGEYLIRHELIAVHQANNPQFYPECAQFTVTGSGTASPPSSVLVSFPGAYSASDPGIDFNIDSPAAKTATSYPVPGPPVWDGASGGTAPQPQPSCHACAVGIGRAPGDLPGPEVWPVWRQVVYRLYGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IG27</accession>
    <name>R0IG27_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_164416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028538.1">
        <property type="nucleotide sequence ID" value="XM_008030347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IG27"/>
    <dbReference type="GeneID" id="19399125"/>
    <dbReference type="eggNOG" id="ENOG502S43V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054062_0_0_1"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA84160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="253" mass="27356" checksum="F92C7977F7137C91" modified="2013-06-26" version="1">MSLPRLDSAPKAEDFTPLSEHQQQTPTSFFGAKPVLHAHYEAVTLSVAADRLKQDAAFSSFGSRREGEEDLVDGVDVWVSSENLILFQNSPSPVGISIPYPSLALHATMKYKSTIEALYMNISLNDAETVNEDDDIHMLEITVLPPSYDTKPTDTCISEFFAALNTCADLHPDPDGSDDGEDIMDDTAPGASGWITADNIDEYLDENGNFKGMVIGEELGPGAGTVRTRDDGDEGSNGVNGADGHEEKYHRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0II00</accession>
    <name>R0II00_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_20330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026887.1">
        <property type="nucleotide sequence ID" value="XM_008028696.1"/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Steffenson B.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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        <property type="protein sequence ID" value="EOA85695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IKV5"/>
    <dbReference type="GeneID" id="19404577"/>
    <dbReference type="eggNOG" id="ENOG502S5RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058850_0_0_1"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42389" checksum="DF31231C18BD32D1" modified="2013-06-26" version="1">METNTNLPPRPGPFGWKRYADKVCNALTDRTAKFLEKYLGVDLIIVTGPAGTGKSSFIKSVTGNEIYTASTLESGGAPYASHGTRQTALVPTLIGGKKYLFLDMPGFDAIDLDDWQIFIMLTTSMATIERYVNFRGLIYVDSFDNVRATKSAEKILKWVHQFCGSSYMANVTIVTTKWDVQADDAVSEKLERYATWRQSALLQPLVSNGATTFHHGLVWNADDWRKLSLRNQQEERNMYARAMIRDRYGTFSNFTLKFYREIAQGSTVEGTSAGKCLRPGPSSQPRQAHQPNSSTENSTRFDWAKETKSWISLLLKAARVYREISGTNNTGMWDFESEPDINWEDGFLFEEDEVHDINLGDEHEELDTSSRCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0IL94</accession>
    <name>R0IL94_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_151928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908637">
        <property type="protein sequence ID" value="EOA85840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026622.1">
        <property type="nucleotide sequence ID" value="XM_008028431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IL94"/>
    <dbReference type="GeneID" id="19397149"/>
    <dbReference type="eggNOG" id="ENOG502SSW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073903_1_1_1"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="285" mass="30535" checksum="21CA0BC65F2791DC" modified="2013-06-26" version="1">MAFSSTFTTSSTTTPGIILSFIQPPSTNTNTTNTTNPEQPEAPETQQQQQEQQQEEAKQEENLSLLPLLFTSHILGTTSSTRYKAAHPDYAKTHVVVSAVADVQRVNVRQVRKFWADQGVAGGGGGGGVDVRVFKEVQVYGKAGGKGGDGDSNTPAHTILLALMQPPPDGAAELDSWYRSEHNEHMSLQPGWRRTCRYLLVAQENSSSDSDNGTNSGSENGNGSGSGSGSSGHSNEQQLSFLAIHEFSADNDLGDTVKPLQPVSEWTKKVMSAALGIDAAIYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IMB3</accession>
    <name>R0IMB3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_169259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026145.1">
        <property type="nucleotide sequence ID" value="XM_008027954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IMB3"/>
    <dbReference type="GeneID" id="19400845"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_3_2_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342447" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="81"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="429" mass="45672" checksum="40AC27E03E64C62F" modified="2013-06-26" version="1">MYLFRGLALALLAGTAPHLVSAWPTAILDAAASDPQLLRRAEEAVRALQGRQVGAGAATAVFEPLRIFNAQAQYVDVSEGSGHEYRAPGPGDLRGPCPGLNALANHNFLPRNGYASVTQYVEATSKVVGMAPGLALFLSTLAGAIDGDILSWSMGGKPSLMQGGLTGVLANGLIGSHNKYETDASPTRADLFQGGNNFKLVTSQFQQLIDYSPGGIVTMDSLMAFRAVRVNTQKKTNAYFFNGPFTGVLVQPAAYAFIFRFMANHTAENPTGILTHEVLQSWFGVQGKSGSYTAVQGGERIPENWYRRPIEYAYDVAYLVADALAAANLHPEFLDIGGNIGTPNSFVAVDVADLTSGVFNTDNLLKGNNLGCFLYQVAAQAKPDIIIGALTSLTDLVGNLVGSLSCPKLQSIDPSKLQQFPGYTRQPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0IMN7</accession>
    <name>R0IMN7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_28681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="192" mass="20767" checksum="E70C81C97466BE06" modified="2013-06-26" version="1">MYFVPLLVFASILWKCSSQLILGTIAVIEFTIEFMEMEAVVATAEISVEGPVVGVTESAVESEVLLQTQELEVGGSYTVRAGIPGQLGRRDVSGSFGFDNVRITDTTVSGSVDITLRPLRVNFDTTTPRVQVSVPYQAGITFGPRHGPGPSHGVSFSMHDAVVHGRGRFGIGRNSHLIWRIRSSTGRFLGSR</sequence>
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                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="20">28A</strain>
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            <name>Zn(2+)</name>
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    <comment type="subunit">
        <text evidence="4">Monomer.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28A subfamily.</text>
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    </dbReference>
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        <property type="entry name" value="PA_dom_sf"/>
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    <dbReference type="InterPro" id="IPR007484">
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    <dbReference type="PANTHER" id="PTHR12147">
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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                <person name="Condon B.J."/>
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                <person name="Kosti I."/>
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                <person name="Salamov A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025072.1">
        <property type="nucleotide sequence ID" value="XM_008026881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IRA0"/>
    <dbReference type="STRING" id="671987.R0IRA0"/>
    <dbReference type="GeneID" id="19403555"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_6_2_1"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA87191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="447" mass="49270" checksum="0F5077B5BB93EA1E" modified="2013-06-26" version="1">MPASSFMHPFASPNAIPPRTSSTGIPNPNTAATSTLKQPSRTSVLRPLSEIDWLGQSKKSKTSHAGEPLNTHPPHQNPPSMASNMSTPTNTDAPLESSTNYPTPLSPPLESTKGIGEELIYGNGVAWTEEKERILLGPYDYLYGHPGKDIRSQCIAAFNQWLKVPPERLDVITNVVGMLHTSSLLVDDVEDSSLLRRGIPVAHAIFGTPQTINSANYVYFRALALLLSMNNPRLIEIFTEELLNLHRGQGMDLYWRDTLTCPSEVDYLEMVGNKTGGLFRLAIKLMQAESQVEMYVSPCISQQRPPQPNQLRNSDCTPLVSTIGLLFQILDDHLNLSPTSGYSTLKGLCEDLTEGKFSFPVIHAIRADPSNQILINILKQKTTDDQVKSYALGYMESKGSFEYSKGVIAELRAKTDEHVSRIEAILGDEGRGGADALRAMLERLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISG1</accession>
    <name>R0ISG1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SETTUDRAFT_184402</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">28A</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024655.1">
        <property type="nucleotide sequence ID" value="XM_008026464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ISG1"/>
    <dbReference type="STRING" id="671987.R0ISG1"/>
    <dbReference type="GeneID" id="19402037"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000055">
        <property type="entry name" value="Intersectin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="139"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EOA87780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="400" mass="45072" checksum="75EB9842E7C9CC39" modified="2013-06-26" version="1">MAPNRIEQDEIEKYWEIFSSLSNGGTHLDGAQAAPVLKNSHLRDDQLERVWDLADVDNDGKLDFEEFCVAMRLIFDLINGVSLDVPKVLPDWLVPESKAHLVQATRALTGSQPAYETVEDDDDTPGLRDGFDWYMSPGDKAKYEEIYTANRDGHGNIAFDSLAGLFESLEDVPDSDIRFAWNLVNPKARESVGKDAALAFLHILNQRSEGFRVPRSVPPSLRVSFEKGNIDYDLNSTANSRWAATRDESTSTGRKAKFGDAYLTRLGVGDRANTYGARGGKGTDFGGRTTEDWEEVRLKKQLRELEQKIADVEKEAEKRRHGRNKDSKPALVKRELELLLDYKRNVLKELDNDEGGAVKGLAGIREEIETVREQVEGLQGHLDNRKAALEDLRRQIEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0IU77</accession>
    <name>R0IU77_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_46927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024128.1">
        <property type="nucleotide sequence ID" value="XM_008025937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IU77"/>
    <dbReference type="STRING" id="671987.R0IU77"/>
    <dbReference type="GeneID" id="19405093"/>
    <dbReference type="eggNOG" id="ENOG502SJXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057891_0_0_1"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="385" mass="42293" checksum="B839889B320ED7C8" modified="2013-06-26" version="1">MATRSQAWHATAPAISPQLIDILVLILYADFLSSDLRIRPFTKLSANMISTCLDLALLCHPVLALLTIQRPKMQTQQSLWQYFLLSFLSLLAVRYVSSTGTQPHILVEAVTGVCQTCTQPNPIAVTYPNNATGVLNGTISVVPISLALARKLIPPQYRILEHAYRHLLPSFPKDMYPVVVQAMLDHDIQAFGFKIPDFSRAGLEFPFLDLLGDNSTSFKWVPSLLITANNSVAIKGSADYGTHTFPATFDSACNAYSGVPDAKRPGTTTSSSAKSTDATTSNTTAALATLFSATTKKPYPISFFANVTNQVIFADAKSCDNQIRLFNTSLSTAPNKIEFVRGSVRAKFWPFDTEHVWNNVYGVRLATAFIENNYLPCENFRGYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVX4</accession>
    <name>R0IVX4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_168012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023436.1">
        <property type="nucleotide sequence ID" value="XM_008025245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVX4"/>
    <dbReference type="STRING" id="671987.R0IVX4"/>
    <dbReference type="GeneID" id="19400391"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_1_0_1"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000089">
        <property type="entry name" value="Threonine aldolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA88756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="376" mass="40579" checksum="317A2BDBF0C8A932" modified="2013-06-26" version="1">MGEASQYTGKSSNSLLDAATIEGVTWGHEKNPAAFDFRSDVHTTPTLSMLKAIQTCSLLDDVMEEDTTTLSLERFVADLTGKEAALLVLSGTMGNQVAFRSHLTSPPHAVICDRRGHIINYEAGGVATLSQAMIQSLDATNGTYLTLEDIQKYAVISDDVHACPTRMLSLENTLNGAIMPLSEVKRISAWARQHGIIMHLDGARLWEAVAAGAGSLKEFCAEFDSINLCVSKGLGAPIGSILVGTTAFIKRSRWIRKSIGGGLRQSGVVAAPMRVAIEETFLGGKLAQSHKNAKRIAKMWTDLGGKLQYPVDTNMVWVDLKASNVDLDSFIELGNKYGVVVRGGRFVVHYQIGEEAIEALRKVFTDALTGKEPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0IW90</accession>
    <name>R0IW90_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="10">PME-1</shortName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_38346</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023343.1">
        <property type="nucleotide sequence ID" value="XM_008025152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IW90"/>
    <dbReference type="STRING" id="671987.R0IW90"/>
    <dbReference type="GeneID" id="19404344"/>
    <dbReference type="eggNOG" id="KOG2564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024818_3_0_1"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="13">
        <location>
            <begin position="96"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA89040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="376" mass="41070" checksum="B0371EB7597582E2" modified="2013-06-26" version="1">MSSLAREFAKTKLSSLPPPEPLQEEPPECEDDSSSASSMSSTGTVRPSGTLRPAPAIHWSDYYAQEFYLEHDRHGAGHAKFHVYLTPPASPKAPLIVLHHGAGSSAMTFALAAKEIRKAMPELGILAIEARDHGSVVWNASGEVDNDLSIAQLSQDLVDMLLLTQAKMGWKELPTTVLIGHSLGGAVVTETANKALLGNKLLGYGVLDVVEGSAMETLGHMHTYLASRPKSFPSLPAAIEWHIRSRTLRNPQSARASVPSLLLQTADGRWAWRTELSSTEPYWENWFTGMSGKFLRGKGAKLLLLAGTDRLDKELMIGQMQGKFQLQVFPAAGHFLHEDLPEKTAEVVVEFVKRNDRSTLVLPPKVSDLLAQGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYE8</accession>
    <name>R0IYE8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_167553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022718.1">
        <property type="nucleotide sequence ID" value="XM_008024527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IYE8"/>
    <dbReference type="STRING" id="671987.R0IYE8"/>
    <dbReference type="GeneID" id="19400220"/>
    <dbReference type="eggNOG" id="KOG0361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="165" mass="16686" checksum="062E228BCC6921C2" modified="2013-06-26" version="1">MTRSSTLGLTGTDLAMGAGGMGSSAGAVQRAGAVLGVGRNVSRVCGGGRGFGCRPLPLPLPLPLPLPLPYTPTTTTTTATTTTTTDTATTTATTTATTTTTPTTPTTPTPARRYRYASTATTAPRQPASTWGPIAAPMPSQMLPAESRIHGDSSMAARSSHRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3M1</accession>
    <name>R0J3M1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_30080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020186.1">
        <property type="nucleotide sequence ID" value="XM_008021995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3M1"/>
    <dbReference type="GeneID" id="19403394"/>
    <dbReference type="eggNOG" id="ENOG502SYWT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162135_0_0_1"/>
    <dbReference type="OrthoDB" id="4788789at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353358" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="120" mass="13487" checksum="4E7D01834E477360" modified="2013-06-26" version="1">MYLHITLLLPAFWSAVAAREYDFCSCQYDSNTQIYFAITDLIAEDCAQPYIYGQANNELWIPAPNGYGPRFSGRYLKLPNGKIDGTTFYNLCKSYGAGDSTCFDCGGFQWNPDRTVMCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3P5</accession>
    <name>R0J3P5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Leptomycin B resistance protein pmd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_133267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020729.1">
        <property type="nucleotide sequence ID" value="XM_008022538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3P5"/>
    <dbReference type="STRING" id="671987.R0J3P5"/>
    <dbReference type="GeneID" id="19396186"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="238"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="593"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="932"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA91570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1177" mass="126113" checksum="A6E6502D50E36C8A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4Z9</accession>
    <name>R0J4Z9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_40880</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020292.1">
        <property type="nucleotide sequence ID" value="XM_008022101.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0J4Z9"/>
    <dbReference type="GeneID" id="19404650"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001935_2_0_1"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 16" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="18">
        <location>
            <begin position="572"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="19">
        <location>
            <begin position="825"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1307"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1368"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1454"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1584"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1623"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1639"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1692"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="15">
        <location>
            <position position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EOA91995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1713" mass="189500" checksum="CD3A4514F2039107" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJ25</accession>
    <name>R0JJ25_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_181592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030843.1">
        <property type="nucleotide sequence ID" value="XM_008032652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JJ25"/>
    <dbReference type="GeneID" id="19401855"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA81348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="574" mass="65491" checksum="E2A680E678BAB88C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJS4</accession>
    <name>R0JJS4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_165985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030987.1">
        <property type="nucleotide sequence ID" value="XM_008032796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JJS4"/>
    <dbReference type="STRING" id="671987.R0JJS4"/>
    <dbReference type="GeneID" id="19399659"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_9_1_1"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF158">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G08970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="131"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA81558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="512" mass="56979" checksum="B978B665E51BA014" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0JMS3</accession>
    <name>R0JMS3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide hydrolase</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_140664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029634.1">
        <property type="nucleotide sequence ID" value="XM_008031443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JMS3"/>
    <dbReference type="STRING" id="671987.R0JMS3"/>
    <dbReference type="GeneID" id="19396572"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_0_0_1"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF57">
        <property type="entry name" value="PEPTIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PA" evidence="7">
        <location>
            <begin position="126"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="8">
        <location>
            <begin position="241"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA82523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="469" mass="48290" checksum="CB222E1144DE385C" modified="2013-06-26" version="1">MRTAIFAALAAAVTANPTLRSRQSGKELVTPDALKAEIKVENLMAGAQTLQTFADSQSNGTRVLGSAACNSTLRWVKDELDATGAYDVELQQVRVVRQVSGQINSSMVNGTNVTASLLEYSPSGSVTATLVPVANLGCEASDYPSAVAGKIALISRGTCAFGQKSALAGAAGAAAAILYNNVNGTLGGTLSPGPRPEGAYIPTIGIAQELGVGYVAAIKSGASISATINVKTEIQNMTTYNVLATTKTGERTNKLCLGAHTDSVAEGPGLNDDGSGTIGILEVAKALAKYQVHNAVVFGFWAAEEAGLVGSKHFVSSLSAEDLAKIRAYLNFDMIASPNYINGIYSSANAPTGSAALESVLNASYASAGANTKPITYLTGLSDHASFQDAGIPVSGIFTGGSELKTEEEARLFGGQMGVSHDRCNHKACDTAGNLSADAFLLSARGVAHAVATFAVSWEGVPERRRVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNQ6</accession>
    <name>R0JNQ6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_165236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029845.1">
        <property type="nucleotide sequence ID" value="XM_008031654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNQ6"/>
    <dbReference type="STRING" id="671987.R0JNQ6"/>
    <dbReference type="GeneID" id="19399399"/>
    <dbReference type="eggNOG" id="KOG1599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048151_0_0_1"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA82848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="300" mass="34292" checksum="111815C5FE775CAE" modified="2013-06-26" version="1">MSRLSYARYGKDNVRLYKVDKDPQTGIHTVVEQTVRILLEGDIEPSYTKADNSVVVATDTQKQTTYILAKQHPIDPPEQFAAIIGDHFIKTYPHIHAAHVKIIQHRWTRMKIDGKDHPHSFYRDGEETRVIESVTRENEGVSIRSKIEKLLVLKSTGSAFHGFHRDEYTRLPETWDRILSTEIEAGWQWKLFKTLDEVKAIDFGAAWKAARDITMKVFAEDDSASVQATMYKMCDLILAAVPQVEAVDYSLPNKHYFEIDLSWHKDIKNTGKDATVLAPQTDPNGLIQCTVTRKDPKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JSV9</accession>
    <name>R0JSV9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_42825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028162.1">
        <property type="nucleotide sequence ID" value="XM_008029971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JSV9"/>
    <dbReference type="STRING" id="671987.R0JSV9"/>
    <dbReference type="GeneID" id="19404793"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056777_0_0_1"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA84133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="284" mass="31925" checksum="E2462BAEEE29EE2E" modified="2013-06-26" version="1">MSQFQFGEASRSASSDDDDDNIASLPFATPLRRSDFLVPDFSPATYLSTLHNRHQTLEDLRSELRARSQLLSKELLDLVNSNYQDFLNLGNSLHGGEEKVEEVRVGLLGFRKEIDGLMGVVGQREKEVGELLEEKRDVRRKIEVGRRLIDYDARLKELEAELLIDTPGQEATNLAGEVSDSDEDEDEDEEEEGYSVSVAKLRRNVVQYQLVLGLEKELGEHPFVAAQALRKTKVRTTLLMDLSTALRQAKRKGAQGAGRVMKIMKIYGDMDESAEAVKVLKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUJ4</accession>
    <name>R0JUJ4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_44918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031308.1">
        <property type="nucleotide sequence ID" value="XM_008033117.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0JUJ4"/>
    <dbReference type="GeneID" id="19404960"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002493_0_0_1"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="101"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="627"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1322"/>
            <end position="1351"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="78"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA82164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="329" mass="37092" checksum="DD56A96C9ECDCC23" modified="2013-06-26" version="1">MSLVDTLLRPNMRDPLPPPSLLVQATKSFADRLGLTTLPYHVHEILLGFLGYHFILYVLSPAVSRLVCPKTYHGFDKRTRFNWDIHWVSMIQALFICAAALWVIIKDEQRHEMDWRGRLWGYTPASGMVQGFAAGYFLWDLQISAQYINIAGTSALIHAIGALAVTCIGFKPFGNYYGLSFVLYELSTPFLNVHWFCDKLGMTGSKLQLYNGIALLVTFFGCRIVWGTYQSIMIYSDIYRALTMSHADPMSSLLETQKCDATSTNNSSMGLDDPGNCSIGDLPMWLVCVYLVGNTALSMLNFFWFNQMIKAVRKRFVPADAKAQAKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXL1</accession>
    <name>R0JXL1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_40161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB908659">
        <property type="protein sequence ID" value="EOA85638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026692.1">
        <property type="nucleotide sequence ID" value="XM_008028501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXL1"/>
    <dbReference type="STRING" id="671987.R0JXL1"/>
    <dbReference type="GeneID" id="19404585"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA85638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="379" mass="42937" checksum="0E5D3644DF4030E7" modified="2013-06-26" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTQQKPLSPERDISSARLASALLTSTGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFAIYLNYTRSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNAQAIAQAANQGQGDEDDKGRGRHVTTTAAANAGTAAGTKRGPVNARQEGTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXR0</accession>
    <name>R0JXR0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_40104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908648">
        <property type="protein sequence ID" value="EOA85698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026634.1">
        <property type="nucleotide sequence ID" value="XM_008028443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXR0"/>
    <dbReference type="GeneID" id="19404578"/>
    <dbReference type="HOGENOM" id="CLU_132230_0_0_1"/>
    <dbReference type="OrthoDB" id="3683014at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="173" mass="19255" checksum="B686DF2A67BE1603" modified="2013-06-26" version="1">MRSLASVVETGPHLLPVVNPDSLHQDNNSMTTIKDATDLFDAGFQKASFMLTSTTTTSDVAQALCGSVTGQVGGTMRTFLKIENLSPYYRLKACMVLSTADEENEHEENLAATRYWLKKATEALEETKRVYVHDPDDAKLLQTMADTIEEENEALQMREKAFYSDDDSDEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYX3</accession>
    <name>R0JYX3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_44361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
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                <person name="Dhillon B."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
            <dbReference type="Pfam" id="PF17107"/>
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        <source>
            <dbReference type="EMBL" id="EOA82852.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="652" mass="75062" checksum="2B87EF16F154F081" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="597"/>
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    </feature>
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        <source>
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        <source>
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</entry>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Zhong S."/>
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        <source>
            <strain evidence="13">28A</strain>
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    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
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    <dbReference type="EMBL" id="KB908844">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
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        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="363"/>
            <end position="485"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="35"/>
            <end position="40"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="120"/>
            <end position="124"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="161"/>
            <end position="162"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="307"/>
            <end position="310"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="506" mass="55304" checksum="DF3ECE394B72B40F" modified="2013-06-26" version="1">MATHTRHDSPIPAAPYQQPAEPKSSRRITKICCVGAGYVGGPTSAVMASKNPDIQVTVVDYDANRIAAWQSDELPIYEPGLMEVVKPARNGIPNKRVPNLFFSTDVDRGIAEAELILLSVNTPTKMLGQGAGHASELCYLEAAVRQIGAVARDNKIIVEKSTVPCRAADTLRDVLRATSKPGVEFEILSNPEFLAEGTAISNLSSPDRVLIGSLNTPQGLAAARALADIYSAWVDVDRIITINLFSSELAKLAANALLAQRISSVNAMSAMCEAVGADIDEVSYAVGLDKRIGPKMLKASVGFGGSCFRKDILSLAYIAESLNLFEVAAYWRSVVDINEYQKDRFTRRIVRCLYNSLSNKTIAILGFAYKKDTGDTRESAAISVVNNLLAEGANVKIYDPQVKESQIRYNIESSNPNPRETKNRLAVCTSTYEACTDADAVVILTEWDEFSNKLARPNGHISWTRVSQVMRRPMYVFDGRNVVDPVPLEALGFRVESIGRSRETYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4G8</accession>
    <name>R0K4G8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_29655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908731">
        <property type="protein sequence ID" value="EOA84449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027921.1">
        <property type="nucleotide sequence ID" value="XM_008029730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4G8"/>
    <dbReference type="GeneID" id="19403348"/>
    <dbReference type="HOGENOM" id="CLU_2607521_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="79" mass="9310" checksum="026BFF0DAB48D11D" modified="2013-06-26" version="1">MENPTWNSRAPIKQHDSSNARATDVQHWPKIVTKENCDDNSTRRPYNSDKRLFNISINFPQQSRAQFNFPGSQRKQYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0K575</accession>
    <name>R0K575_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_43275</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028875.1">
        <property type="nucleotide sequence ID" value="XM_008030684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K575"/>
    <dbReference type="SMR" id="R0K575"/>
    <dbReference type="STRING" id="671987.R0K575"/>
    <dbReference type="GeneID" id="19404841"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000143">
        <property type="entry name" value="Dolichyl-phosphate beta-glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="128"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="413" mass="45568" checksum="091B831C34CA7B86" modified="2013-06-26" version="1">MSRENRAFDTEAFGAGYGFESFPTRAVEMPPTWVLGVGLGFLLCALGFWAYVALTLVAPVPRPPRRSEKQYITILPDGARSGPQELPCWLDKWAAEKEAAKQRAAKEPGSKVVVPPQMPIEEAELFISVVVPAYNEEDRLEGMLEEAVEYLQSKYGDAHAGEKGGTSEKGWEILIVNDGSSDKTVDKALDFAKEHQLSLHPKAKPGPWSTDKTPHSTHIPHGSIRVISLEQNRGKGGAVTHGMRHVRGRYIVFADADGASRFSDLGALVQGCQSIEDKHGRGVAIGSRAHLVGSAAVVQRSRLRNFLMHSFHLLLRIMTPPATARIKDTQCGFKLFSRPSLPYIVPYMHSEGWIFDVEMLMLAESAHIAMIEVAIGWKEVMGSKLNVVWDSLGMAWGLALLRACWIAGIYRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0K577</accession>
    <name>R0K577_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_136615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="R0K577"/>
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    <dbReference type="eggNOG" id="ENOG502SMPD">
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
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    </dbReference>
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        <location>
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            <end position="21"/>
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    <feature type="chain" id="PRO_5004344230" evidence="1">
        <location>
            <begin position="22"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="424" mass="45185" checksum="C783467FE57674A8" modified="2013-06-26" version="1">MRSHLILAAASLAVASPAPQAFDVNLFNNIPNNAPQGPPAGVVSNKAYDDTKAVVDAAAKASGPATAQLAKKSAMPDLERRWGSSWNNWNCALPPANEPSTNMAPSSCTPVSWTNTFAFTAAPGCATDIEVGTYCGFINPEDPCAAQPNAYGPHVTPDTADAFQNDAALHELAISAKTPSGYTKAFTDLSASVSGSGYLGYYELTAYDPATCAAKCESTKSCTGFNVFIERDPQFNPRQCSCTSPPSVTRFKCSLWGQDVTTQSATNTGQDQDGFQVIIIGSNGYNKQTYTPPNPPSCSRPQSCGTGLINQQPYCMGQTTIPGPFNPSLCAAYAQKQNQVNRQTGLMGTFLSMFGMNKGGCVQFQAAYLEKGGVGFGTHCRLFTKKFAPSNVNLDIKVSTNSQWGCQKSYLWDVDVNADFTWGR</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="2">DUF7371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">SETTUDRAFT_171776</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502SRUH">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073107_2_0_1"/>
    <dbReference type="OrthoDB" id="5385013at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055795">
        <property type="entry name" value="DUF7371"/>
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    <dbReference type="Pfam" id="PF24086">
        <property type="entry name" value="DUF7371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="266" mass="28656" checksum="E64F28164EAD509C" modified="2013-06-26" version="1">MFPSSAPSRSFSTSFVTLVPIANVSSSSVMLNSSTSTTTSTSTITAPSTVAQPDLPGPSSCGESGNFTIGFDDTVVDEQSTGLLVASGMNNPYHHLFYANGYTYVPDKWEPYPAISQPNVAMFMPLGGRLLPNTPFAGTMLPGELGAGPRAPVNAYWFNAYSGYFGCALNGLTPCTLRISGFRWDNVVGQEVVVAEQKVTIPACFGYVGCRLTQVVFDEGFRALSGIQFKAYTYNLNIPQVHMMDDLQMEWYNNTCSAGILRIGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5G4</accession>
    <name>R0K5G4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_149807</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008026110.1"/>
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    <dbReference type="AlphaFoldDB" id="R0K5G4"/>
    <dbReference type="STRING" id="671987.R0K5G4"/>
    <dbReference type="GeneID" id="19397037"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd04077">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
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        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Subtilisin-like"/>
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    </dbReference>
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        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344235" evidence="8">
        <location>
            <begin position="22"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="156"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="346"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA88278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="401" mass="42323" checksum="62F941481BED2008" modified="2013-06-26" version="1">MQYFTRFLGLTLAAAPFFAQAAPLSTRSTEHSITEKYIVQLIPGVEIASVTAHHEQVRSIKARNLGRRDGSDEAAGINEFDLGDFKGYSGLFDSATIAELKTLPQVLLVEKDFEMHTTLSQQQNAPWDLASLSSRTRGATDYFYDSTAGLGTYSYVIDSGIRTTHVEFEGRASWGYNAVDTINTDSLGHGTYVAGIIGSRTYGVAKKTNLIAVKVVKGDGVVNFSYFLDGLNWALRDIVAQNRRPTAVINISLGGPASSALDNAVASVSNQGVLIVVAAGNDNAPADYYSPARAPTALCVGSVDANDARSPWSNYGSAVDIWAPGSSIITTSHTSDTAIVTQSGTSMAAPLVAGLVSYLRALEGPSIGQAARARVLALATTGRLTDTLGGPNLLAYNGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0K690</accession>
    <name>R0K690_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glycosyltransferase family 24 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_137335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA85034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029335.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0K690"/>
    <dbReference type="GeneID" id="19396407"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354015" evidence="10">
        <location>
            <begin position="27"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="41"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="273"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="410"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="666"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1202"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1484"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA85034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1504" mass="168492" checksum="150D5310BA9F77DB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6C8</accession>
    <name>R0K6C8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_168410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023948.1">
        <property type="nucleotide sequence ID" value="XM_008025757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6C8"/>
    <dbReference type="SMR" id="R0K6C8"/>
    <dbReference type="STRING" id="671987.R0K6C8"/>
    <dbReference type="GeneID" id="19400538"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA88558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41639" checksum="0520E7883A359B80" modified="2013-06-26" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAISRVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGISDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6S6</accession>
    <name>R0K6S6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_92557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028436.1">
        <property type="nucleotide sequence ID" value="XM_008030245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6S6"/>
    <dbReference type="STRING" id="671987.R0K6S6"/>
    <dbReference type="GeneID" id="19405980"/>
    <dbReference type="eggNOG" id="KOG1861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015513_0_0_1"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="214"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="456" mass="52028" checksum="23FF1A96731294A0" modified="2013-06-26" version="1">MAPEAPKKKVEWPPAVREYVRRAFDPANAIPGISQAEMQARLKTTIGWFAERNSHDTVHWPTFPLPQELLLEERRVAALGTPVNGGVNGMQTTYVNGSAEQTNQTTPLSKKRNVHDTEEAQAEQGQTTMPPWRKTNLASRMTYADGHSEKRQKKNAFAESASKFDQGELDKRRQRFQLSNNGSKTTPPPWGSPRKDEDEMSSGPVVGTNEKLEKSYFRLTAPPKAETVRPLHVLKKTLAMLVERWKAEKNYNYICNQFKSLRQDLTVQHIKNAFTVKVYEIHARISLEKGDLGEYNQCQTQLKSLYGQKLGGNPAEFKAYRILYFVYTCNKTDMNDMLAELTLADKTHPWIKHALDVRSSLALGNYHKFFRLYLEAQNMGAYLMDIYVNVTLRFLTDELGFDNDESCREFLESHGGQNIIEDRGDGQHRVRIREVAADIERLRAAAFSKVDIKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0K796</accession>
    <name>R0K796_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_32615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027050.1">
        <property type="nucleotide sequence ID" value="XM_008028859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K796"/>
    <dbReference type="STRING" id="671987.R0K796"/>
    <dbReference type="GeneID" id="19403672"/>
    <dbReference type="eggNOG" id="ENOG502SNQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021599_2_2_1"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="482" mass="53211" checksum="9DC89316F70253A2" modified="2013-06-26" version="1">MHYLPKEKEGYDLVQPACGQCVGRGIACGGYDSDRIFIYQRGGSNRSAPKGDTSPTPKTYVDEPSRHSFQIVPATSVSAIEVRNPSFTSVSILPPAGLAKSAYSQKTIAAFLDMYNPAGTIETTNVDAKELVTLLPMLSTRDEALQMAALAVGIAQLGITTKNEHLTRQGRALYGKALKETAVALRNPARANSESILVVPRVMALFELLFGAEPQSANQAKSWLSHAVGELAIIVSRGPAAFATDDVAHNLFTNARYRLLGPAIRCRRATILNTEEWKTLPWQGRTKTSEDLLVDILCGIPEILEAVDRLQYESMDSGERSAPGTWAQAEANVIYTPEIADTCTQITFPNIDVACITVRYWLTSLFLYSSLDIAAGIDLSTDFSLSHPDRPHPRPFARMITRSVDYFMQEKFGVTGLVALWFPLGNTLFYLNRNREADVEYIKTIMKAWNQPKLPSVMRDFLMSFRMTVDMTTLLATPIQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0K875</accession>
    <name>R0K875_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein FYV10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_147384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022994.1">
        <property type="nucleotide sequence ID" value="XM_008024803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K875"/>
    <dbReference type="STRING" id="671987.R0K875"/>
    <dbReference type="GeneID" id="19396916"/>
    <dbReference type="eggNOG" id="KOG0396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027445_2_0_1"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="9">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="358"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="8">
        <location>
            <begin position="358"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA89138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48355" checksum="0D05CF164A6115D8" modified="2013-06-26" version="1">MAELTSTKLNAESHLLLDQPLLRMPYELSRRNFKNAQRAIEHSTTAFTTSLNATTKAASKGTAAPAATLESLDTLITKMQGLKRKLEGLHEEESRIHRSAKARLQHLQDLYGVHSLVDVKYDEWSRTRLSRLLVDYLLREGYAESAACLAQSKGITELVDVDAFVGCHRIERSLREGMSTTLALEWCKEHGKELKKAGSMLEFELRLQQYIELVRQGHEAGLSGMDGVETADEGGSMHGVSIRGGSGGGEAKLVEARAHAKKYLSTSGDFKLMRQAAGMLAYRPWDEVEPYASLYSRSRWSHLADIFLSTHHNMYSLPPRPLLHIALSAGLSALKTPACHSEYTSSSTNASSSATTVCPICSAELKELARNVPYALHTKSIVEDGPVVLPNGRVYGSERLRVFNEKIGTEKGWVRDPVGGLAGEKWKESELRKVYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9M8</accession>
    <name>R0K9M8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_146765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022643.1">
        <property type="nucleotide sequence ID" value="XM_008024452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9M8"/>
    <dbReference type="STRING" id="671987.R0K9M8"/>
    <dbReference type="GeneID" id="19396886"/>
    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039352_2_2_1"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="150"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA89683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="295" mass="32368" checksum="356558CD38F8C941" modified="2013-06-26" version="1">MSDAERAPKKRKAESGERQAGGNKRAKGRKNWDMPKRDTSNRAIQAGDAGIWATCAMKKEAKSVADLRDLFQEYATQLYGTTESSGAAADTDSDSEGDIEAEINKELADIRKPATKPLFTSVKLDTQCLVFFRTRSPLEPVSFVHKICQDIADGAQPKNLTYVKRLTAITATAKATPQGLDSVAKQVLAPHFHGPDQAGKKFAIRPSIRNNKEFSRDHVIKTIAAAVGPGHKVDLKSYDLLIIVEIYQNVIGMSVVGPDYEKLKRFNIEELRQPLSSAVPETKENANKATSEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9S0</accession>
    <name>R0K9S0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_39623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1620093_0_0_1"/>
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    </dbReference>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="164" mass="16797" checksum="B127D7F3904FADE8" modified="2013-06-26" version="1">MIAGDAPAVIPDRKDERSDFAHGGDECAIAWQDCVCTASVSEEHVQKASEAATPAAAGPNGAEGPALGPKQQALRAAHFNLPSSAPICTHAAASPRPQHQGSPANSPMKLVSRGDGHKHHDHHWVVDKSCIYLAVTRHGRPPALGASSRVPSQGSAAVTGGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9W1</accession>
    <name>R0K9W1_EXST2</name>
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        <recommendedName>
            <fullName evidence="3">geranylgeranyl diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_163772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.29" evidence="3"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027519.1">
        <property type="nucleotide sequence ID" value="XM_008029328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9W1"/>
    <dbReference type="STRING" id="671987.R0K9W1"/>
    <dbReference type="GeneID" id="19398887"/>
    <dbReference type="eggNOG" id="KOG0776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_1_0_1"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA85027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="459" mass="50038" checksum="EF5CA448A7F55E92" modified="2013-06-26" version="1">MSSRTPGLATLIARPQTSSSPSALRRSSCPYSSFALSRPRTSQNAVSPPYHHPSRRRPQSSWAAAVNVAQHVRSTPPPDAPIKMDPFQTVAREMKFLTGNIRQLLGSGHPTLDTVAKYYTQSEGKYVRPMLVLLMSRATALTPHRNVARGDMGIGRQSADASITSPSILADDNPDTNPITSIRHDSAYTPDDSDILPSQRRLAEITELIHTASLLHDDVIDHSVSRRAAPSANVEFGNKMAVLAGDFLLGRASVALARLRDPEVTELLATVIANLVEGEFMQLKNTARDEKNPVWTEDTLTYYLQKTYLKSASLISKSCRAAAILGGSTPDVVDAAYLYGKNLGLAFQLVDDMLDYTVSEAELGKPAGADLELGLATAPLLFAWKENQSLGKLVGRKFSQQGDVQQARQIVSQSSGLEQTRALAQEYVDKAIDAISFFPDSEAKTGLLKMCTKVMKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA29</accession>
    <name>R0KA29_EXST2</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_28670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026096.1">
        <property type="nucleotide sequence ID" value="XM_008027905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KA29"/>
    <dbReference type="GeneID" id="19403266"/>
    <dbReference type="HOGENOM" id="CLU_2086283_0_0_1"/>
    <dbReference type="OrthoDB" id="4492972at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="117" mass="12720" checksum="00E71609D6541036" modified="2013-06-26" version="1">MAQTSGISTSSPDSPSVDIMTCKACRRFDICAKSTVCISMSSGTSQSVVEKYRYEILFGTWLAVTGATFLRIKRQPYSTSLKIEQYESIFKGTSLSAVLIGIGITPARSTARRFTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAM0</accession>
    <name>R0KAM0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_158652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021961.1">
        <property type="nucleotide sequence ID" value="XM_008023770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAM0"/>
    <dbReference type="STRING" id="671987.R0KAM0"/>
    <dbReference type="GeneID" id="19397846"/>
    <dbReference type="eggNOG" id="ENOG502SKYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_2_2_1"/>
    <dbReference type="OrthoDB" id="2932980at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA90013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="275" mass="30536" checksum="5100D30870D457C7" modified="2013-06-26" version="1">MVNITGLLSSLITANHILSYHNVLDSFGHVSVRNPETNTTFFIALQLGPAIISGRADIGEYHISDGSPLPGTKGGYSERFIHSEILKRYPDINAVVHSHAEDVLPFTILPDVAVEPTYHMAGFLGSAVPIFDIESAYQDGDARDLLVDTVRLGSKLAERFGRNESRWQSPKHSTVLQRGHGFVTVATSVQQVTDWAYYVASNARVQWKAVVLAGAQQQSHGCGHGVQYLSQRERLDTAEMNRWIVFKPWRQWVIEVERSGRYINELGTPPLGDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAZ2</accession>
    <name>R0KAZ2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_89812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027813.1">
        <property type="nucleotide sequence ID" value="XM_008029622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAZ2"/>
    <dbReference type="GeneID" id="19405797"/>
    <dbReference type="HOGENOM" id="CLU_064143_0_0_1"/>
    <dbReference type="OrthoDB" id="3799546at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="368" mass="40767" checksum="ACB208261C1F099F" modified="2013-06-26" version="1">MTAKVPASDTYRKLHRAMTPAEKHAKQQLLDDQVSFIIVMRDNNKPDVYGQTSTTCGPLPWSAVATAYNERYNVSVTPAAMEKRARQHRDEWLENNPTYPTKIEYAKKARTPRTSATSGIVKTGAPRARGSVENGVRRAMATGITVRPWRGGEATQASFYNNRIGGWLPPCGIREQANIQEYMKSASISHTRVAIEIVDAHGVSLGSVTADREAIRTSSAVLRGCLDDNTGMKMQLRGPSVDAVRWYIHCVSLGMMVDFSKYGNCDSASLVELYCLATQLGDDHVRELVLHQWQLFAEQNAEMELEIDDLNLLFESTEDGDPARDWWVETVCASGLAGQLLEMARHPALATQMRTLPSSEICLDMGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCM7</accession>
    <name>R0KCM7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_144602</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021428.1">
        <property type="nucleotide sequence ID" value="XM_008023237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCM7"/>
    <dbReference type="STRING" id="671987.R0KCM7"/>
    <dbReference type="GeneID" id="19396771"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120105">
        <property type="term" value="C:mitotic actomyosin contractile ring, intermediate layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902846">
        <property type="term" value="P:positive regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902854">
        <property type="term" value="P:positive regulation of nuclear migration during mitotic telophase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905758">
        <property type="term" value="P:positive regulation of primary cell septum biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="252"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="556"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA90633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="655" mass="74735" checksum="EC3797DB329C6EFB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCT7</accession>
    <name>R0KCT7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_56680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025157.1">
        <property type="nucleotide sequence ID" value="XM_008026966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCT7"/>
    <dbReference type="GeneID" id="19405218"/>
    <dbReference type="HOGENOM" id="CLU_2892251_0_0_1"/>
    <dbReference type="OrthoDB" id="3795878at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="61" mass="6883" checksum="3C46212706FAB051" modified="2013-06-26" version="1" fragment="single">PYRFRPWDSLNYKVTISRKTKEEEATAHTAYIQSRMGDNFTAIYSDASKIQEGKGIGVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCV6</accession>
    <name>R0KCV6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_19723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024943.1">
        <property type="nucleotide sequence ID" value="XM_008026752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCV6"/>
    <dbReference type="STRING" id="671987.R0KCV6"/>
    <dbReference type="GeneID" id="19402230"/>
    <dbReference type="eggNOG" id="KOG0280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036100_1_0_1"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA87189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="380" mass="41795" checksum="D78468A3F5C15AF4" modified="2013-06-26" version="1">MSSIQSLTSFRLHLPPSCIEFFPLNPQYAVIGTYNLENPDDKEAAGSAPHDGKVSAKNQQRNGSLILVKIDGDNVNIVRTLATPSAVLDIHFLTHVTSSNFGVATSTGAFSIYELQSWQRNPHISHIKTIQYFPEDILITAFSWHPESFMVGMTLSNGQVCLGVIDSESQDDAPTKLQVASHDLEAWTLAFLPDGSGILSGGDDSALRFAELSDGSGGSVPWMDGKIHGAGVTAILPVHLDSQGCLLVTGSYDDHIRIVHVPISGRRQVLADTNLGGGVWRLKLLDRNPKLPAHHRVEKWRSEPPPEAILLLVSCMHAGAKIVKLTKNASKDWQIEVLAKFEEHESMNYGSDCQPDVNSQGQRTFISTSFYDRRLCLWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDD3</accession>
    <name>R0KDD3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_36420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021303.1">
        <property type="nucleotide sequence ID" value="XM_008023112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDD3"/>
    <dbReference type="STRING" id="671987.R0KDD3"/>
    <dbReference type="GeneID" id="19404137"/>
    <dbReference type="eggNOG" id="ENOG502RIXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1267575_0_0_1"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="218" mass="24511" checksum="281BA6148844A223" modified="2013-06-26" version="1">MKTHVKLALRLYAKGKLSLQNVQSQNIDVKFLSRATDTSGKQRILDRKADYTLSYSHDTAPFEALYARLLQHRNQCISHTTDAFTKTTAVFSGVEVKPANGDKLEAQYQLSIWMAANLRKKTKLARHAGLPDTTYLIEPGFTVVGHELYFYIAYMDSRQGEAVRILEFGNAATSSISGAFRQLRMWRNVIEYGLEEGPDGFWGGFLKPVLEKLAAGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDJ6</accession>
    <name>R0KDJ6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microtubule associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_88387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA87434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008027648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDJ6"/>
    <dbReference type="STRING" id="671987.R0KDJ6"/>
    <dbReference type="GeneID" id="19405702"/>
    <dbReference type="eggNOG" id="KOG4302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
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    </dbReference>
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        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        <location>
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        <location>
            <begin position="701"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="87284" checksum="CA5C3966DED7DA0A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDN3</accession>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
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        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
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        <subcellularLocation>
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        <subcellularLocation>
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            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="125"/>
            <end position="207"/>
        </location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA87459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="235" mass="26281" checksum="FB5221ADB0944310" modified="2013-06-26" version="1">MPKSKRAKVVHLTKTDKKGKELSLKLFANVQEAADTFQHIFVFAVENMRNSYLKEVRAEFSDSRFFFGKTKVMAKALGQTPAEEHLTNLSQLTEHVNGNVGLMFTNRDPGEITEYFANYSQTDFARAGVVATQTFTVPAGVVYSRGGELPEEEDVPLPHSMETTIRKWGMPTRLDKGKVILDAPYTIAEEGKPMNSHQTALLKLFGVAMADFRIDLKAYYSKTTESVTEVGAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KE33</accession>
    <name>R0KE33_EXST2</name>
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        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">SETTUDRAFT_158566</name>
    </gene>
    <organism evidence="12 13">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025190.1">
        <property type="nucleotide sequence ID" value="XM_008026999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEC4"/>
    <dbReference type="STRING" id="671987.R0KEC4"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="GeneID" id="19396267"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="10"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="241" mass="26784" checksum="8637D3CE6A7D3EDC" modified="2013-06-26" version="1">MSTAQTYSKHFIPLESNPEVFTELAHKLGLSASLEFEDVFSLDEELLALVPRPVLGLILVFPTTEEYEKKVEDEDALLESFQSSEQSEDVVFFKQTINNACGLYAILHTVCNGEARDRLKNDSVIAKVLNTSSSVDELVEALENSTELETSYASVACKGNTEAPSSAEEEVDYHYIAFVKCKNDHLYQLDGDRKRPIDLGQLTADEDVLAERCLIAIRSMMALEADNVNFSLMALVEAAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEE9</accession>
    <name>R0KEE9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_132689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020544.1">
        <property type="nucleotide sequence ID" value="XM_008022353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEE9"/>
    <dbReference type="STRING" id="671987.R0KEE9"/>
    <dbReference type="GeneID" id="19396161"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344343" description="CN hydrolase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA91233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="299" mass="32799" checksum="E7B3E5FBC096E0EE" modified="2013-06-26" version="1">MASLLKKSLKLALIQLASGADKTANLRSARQKVLDASKAGAKLVVLPECFNSPYGTKYFDRYAETLLPSPPSESQSQTFHALSQLAKEAGVYLVGGSIPERDSQDSKKLYNTSLTFGPSGELIATHRKVHLFDIDIPGKIRFKESEVLSPGNKITLVELPEYGKIAIAICYDIRFPELAMIAARKGAFLLLYPGAFNLTTGALHWELLARARATDNQVYVGLCSPARDMQAEYNAWGHSMVVDANAQVVEQLDEKEGVLMAELEAGKIEEVRKGVPLYGQRRFDVYPDVSEGGRFEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFI1</accession>
    <name>R0KFI1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_163004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="514"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EOA88089.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="535" mass="55779" checksum="A03763687B6E1639" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KG12</accession>
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        <recommendedName>
            <fullName evidence="4">DUF3176 domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_133621</name>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="671987"/>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="254" mass="29335" checksum="A5FAAF03AD943AEA" modified="2013-06-26" version="1">MSPRQPDPGSPSASHDAVPDQRTKVVKSRTKKSSLKYRNGLLKAEISTRSESMHIARRNATESPLLRLPAEIRNKIWQFTLGYHRIMIYYQFANIYGIGRRAIQLAHSVYAGDPTTEGSIVQPGFALPIVCRQTYVEAFAMVYSLNTFNFSHRSTLDHFIRNRALGQRRLVASIVVPCDYFRLYRSDRRKRFRQTFPNLKHVRVLVDSNRLGWNLFLEPDREQFLNTEIKDFILSKEGDGLEVDFVVDFHGISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KI74</accession>
    <name>R0KI74_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_184376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024620.1">
        <property type="nucleotide sequence ID" value="XM_008026429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KI74"/>
    <dbReference type="STRING" id="671987.R0KI74"/>
    <dbReference type="GeneID" id="19402034"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF11">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="298" mass="32255" checksum="AB3F495B4CA1DAF5" modified="2013-06-26" version="1">MTTFTIPDSQLDAIRDQVVLITGASSGIGLATLRRVIQHGGKVFASDINPLPQPEGASVPFIKANVASWQDQVDMFKAAEKEYGKIDHVFANAGVGMSAPLVDDEVDEKGEPRPPKLDTININLIGVMYSVKLGIHYLRKNPCGGSIVTTASGSSFTRVELSDYSQANTVQAMSKHAVLGLTRALYRELHPKLPIRINSIAPSWTDTAIVPREVIALFGEGSYQTADVVARSAMILMVDQTRHGEMVYSDRGKFVEMENGATGFHAQTKKTLGFAEDEETSEAKAWQRAQEGFAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKB6</accession>
    <name>R0KKB6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_46681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023770.1">
        <property type="nucleotide sequence ID" value="XM_008025579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKB6"/>
    <dbReference type="GeneID" id="19405072"/>
    <dbReference type="HOGENOM" id="CLU_1769257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA88432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="147" mass="16311" checksum="3288531D5581E6FD" modified="2013-06-26" version="1">MGARPSDPLHQLILGASIRMLHGGHLRSICRPETEHPEKDRPVASDAFHFARGKADSTVPDDSCCTLNGTPRTEGPARVNTLRGDMKLISFGFFHGALGGVKTAKTSYMWFYRHKGESILSRQQTKDPAVCQSITLHICWYRPHAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKY4</accession>
    <name>R0KKY4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-14 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_26135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022414.1">
        <property type="nucleotide sequence ID" value="XM_008024223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKY4"/>
    <dbReference type="STRING" id="671987.R0KKY4"/>
    <dbReference type="GeneID" id="19402979"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017137_1_0_1"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
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            <end position="288"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA89809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
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        </source>
    </evidence>
    <sequence length="344" mass="39245" checksum="DD665B97D3E98387" modified="2013-06-26" version="1">MLAVETGMSDMRVLDDSDSSANSVETAASHSSPVPAASNAPGNRPGCRRVLVPITSDTEFFTRLTSEVSGLEKLQEREQKRMNVQIEALGKQVAKLTDPDRRSSRKMLTTWRHIFQIYVEEGIFFGTTELDHKSHDSQKAMARLATFSNKIAKAGLVEQLKKKDNLVALNTFMHINREILQGLRFGEINHNAMTKILKKFDKRTALGVKSTFPRQVEYPEFSEHLAKAVCAQVNTQILSHVPQIDDYSCPMCMEIQWRPVKLSCNHTFCIRCLIVMQNNKQYNCPFCRERTIFNANSDNLDTEKAAFLKKWFPNEVKDKQRYNEMMAGVDQYGEVYANEKCTVM</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="328" mass="36516" checksum="DB212BC04B1B7772" modified="2013-06-26" version="1">MATVGAFFYSQLFVTPPKPTTDLTGKTVLVTGSNVGLGKEAARHYTRLNASTVILCVRSLEKGEAARLDIESSTGRTNVVKVMHLDMSSYASVLDFARQASESLSRLDIAILNAGVLRKTWEIYEQDESTITVNVVSTFLLAFALLPKMRDTATKFNTRPTLTIVSSEVHHWTKFKERLAPEGHLFERLNQKEVAGKKVSMQDRYMVSKLLEVLFVRAFCERNSAERVPVTVNLINPGLCQSEFGREAPFFDAIFRFLLGRTTEVGSRTLAHAGLQGAESHGKYLSDCKIEEPSSYVRSAEGKKDQQRVWTELVAKLEAIKPGITEGY</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
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    <dbReference type="STRING" id="671987.R0KLS2"/>
    <dbReference type="GeneID" id="19394986"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36554" checksum="F93517BAF47606CD" modified="2013-06-26" version="1">MNGDEAKRLGEKLLAEVQVKDLSSVPTFHFNIAELDALIPGSKPPILELVSPPLTHDASGSGKTSLLYLIIATAILPRTMSCIQLDGHESAVILFDPLHHFSVVRLAEVTLHVVMTKLQAASVGIDSTTKQQMREVVKTALSHVHIFHPPSWPLFLATLRSLPDYLFDATKHHSTHRRIHSIILEDVDAFVPEIRSSAPASSFSSSTSSSSANALSPASSTLAFHLTKLSSLLSSAVITTSHSTSPLYYRPALPTSWPRDTLVTRLALRRVPVAKFAPGISNEEAEAEREKRWEVVSRARFECWKVGMGVGGQGSGGFVFRIGRHVETERKMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0KM60</accession>
    <name>R0KM60_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_36838</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="HOGENOM" id="CLU_1918390_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="132" mass="14385" checksum="D200CADBCB6B2506" modified="2013-06-26" version="1">MARRGRAEQSRASNTWQEDEQEDEQEDEQAQERRCANVRRRTHAPTAGEGAGAAFWVDGLAVGGGGGGSNQSHGQAWCILDTWTYMDRDIDGCMLQCSTDADADADAAGCSVRRDPWQIPSESCADYHVCMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0I841</accession>
    <name>R0I841_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_98919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031083.1">
        <property type="nucleotide sequence ID" value="XM_008032892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I841"/>
    <dbReference type="STRING" id="671987.R0I841"/>
    <dbReference type="GeneID" id="19406402"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA81690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="545" mass="61201" checksum="BFCC04C88106222D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8N2</accession>
    <name>R0I8N2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_34648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030097.1">
        <property type="nucleotide sequence ID" value="XM_008031906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8N2"/>
    <dbReference type="STRING" id="671987.R0I8N2"/>
    <dbReference type="GeneID" id="19403931"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
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        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA81880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14317" checksum="65852AFBD9761749" modified="2013-06-26" version="1">MSAPKVKTAQLWNKSKDELAGQLADLKSELIQLRTAKVTGGSNTKLTRIHDVRKGIAKVLTVINANQRAQLRLFYKGKKYTPLDLRPKQTRAIRRRLTKHEASLVTEKQKKKQTHFPQRKYAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8P4</accession>
    <name>R0I8P4_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_166133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
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    </dbReference>
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    </dbReference>
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            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA81771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="308" mass="34959" checksum="952281A4A87BCD11" modified="2013-06-26" version="1">MASHEQYILRVTAGPTYDVAQHDPVPVNSERPVRITSDLIDAKLHMRIKDFRGLPEGSPATSPYFSTPQHVYDRYSISFSFTPRSDIAGDKLVFGNDFDHPIRDRLPPLFDKAFGIVKWWIDPGLDGDVYADEPYLYGALLSSINVLRIGAKNEEEKPGDASEQGEAAIYEEGADGDGMDIRKAKGVPDKPGARQKFFLTQQNRDDFTFEAGREYMCDFFNPYLDFNEFALKIGYGLPNISMIRHWDGQPLRYVLKNRETNQELFVVVIELVPTEQAKKDGVEDAKEKFEEVHGTKDEDTNGHQDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAA0</accession>
    <name>R0IAA0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_23500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG4439">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5383027at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SNF2_N"/>
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    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="772"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1006" mass="114421" checksum="42D2E9CE412E3CA6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICY0</accession>
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        <name type="synonym">Setosphaeria turcica</name>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031295.1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1661874_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="159" mass="17340" checksum="CCA7FEEB5C86BEE1" modified="2013-06-26" version="1">MATKSPISVICGYSADRVSAVHAVDIEYADYYGRSSSVITGQGAMMTAWIVILHLSRLETSDKLIEESKHQISKHSCTKESNKPSKNRGFTRRAARRNLLDSICKILTFVRNFEGNPSAYGDSAPSAPTLTQTCVSLYQGAQGVCPIVGHAACILNDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0IDM0</accession>
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        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_94839</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008030968.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA83445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="90" mass="10079" checksum="5413FDEC78EA72E5" modified="2013-06-26" version="1">MDSFGSSDPKTAVMRQVQQEAAMQNARMLVEKLNEHCFERCVPKPGTSLSKGEENCFTACMEKYMSAWNTVSKQYVGRIQRESAQGGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IE89</accession>
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        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_33758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908833">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="R0IE89"/>
    <dbReference type="STRING" id="671987.R0IE89"/>
    <dbReference type="GeneID" id="19403818"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2537459at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
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    </dbReference>
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        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004352913" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA83466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="410" mass="42896" checksum="7AD4D91293306A3C" modified="2013-06-26" version="1">MDLRSSTTLLGLATLSTILLSIPAGAADWTYSYCSSLNTGDQSTSYTWPYQSNGNCTNHCKQDGGPWAFAVIQYTNCWCSNYVPGTTADSSGCLVDCPGFPDEKCGNKDKGLYIYVQMDGQPSGTQGGSSSTAAPASSSQNSPPSSSPPPPPPSSPSPKPTSAPPPPQVVTSILTQNPETIEKTVTVQPAPSSSPPSTSTVFRFEPSVSHLLTGVQTKKPSTNDSPAATEQPVTVPTLVTESGMVITRTVVITPIPAASTGQDSNKSSTDVGAIAGGVAGGVVGLLAIVGVILFLLMRRRRQREQNGQEGGAGITRNVSTMSRAGLLGGQAEKTTPLTTTFGSQRSRHDDDSITPVTPSTRRLSQPILVDSRLNPAAVLTFHGNQSRESLGSIDDSRDYGRQLNVRNPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0IFR6</accession>
    <name>R0IFR6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_93687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028483.1">
        <property type="nucleotide sequence ID" value="XM_008030292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IFR6"/>
    <dbReference type="STRING" id="671987.R0IFR6"/>
    <dbReference type="GeneID" id="19406049"/>
    <dbReference type="eggNOG" id="ENOG502SEIT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513849_0_0_1"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="486" mass="55626" checksum="C7A5198756F70EA1" modified="2013-06-26" version="1">MASNNDDSRRDNRRPEDNPFIAFRRFADSQVSSLLNTVFTLPATLANYNNAHQARERCLFGKADQRQCDRLHGIEAEIAELRNEGRELFRVGDVQAVLRNSEELMKLDRKADDIRREILHDSDGETQKDMARGSDTELVERVANKKGQEWGWSWDWGFPRPFDHERRNARETSEEQDADVFAALERLLRLQAEASRLAQDFEDKAWNDSATKVPRIWSWSKSWQWPPQADASQPDNDPYSPRALEQNHALDKAGVPWRVAYEDLLRIKQNERPHDAASEERTEWANGKIPVTQRQSQEEMERGNESSYPRLAAQDEPSYEYSHDHEDQHDDPPTPKRAQFPFNAFRRDASSQPPRAAAEYGDYLKEWQEAATEMDAYEHLDATSANTAVSSSSRTDKTNEANPSILSTLTTTERTVAPDGSITTKVMLKKRFADGREESSETVHTQRGQETDAPARDPWKALQNAQSSSSSEGEANKKKNGWFWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0IFY4</accession>
    <name>R0IFY4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_164300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028397.1">
        <property type="nucleotide sequence ID" value="XM_008030206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IFY4"/>
    <dbReference type="STRING" id="671987.R0IFY4"/>
    <dbReference type="GeneID" id="19399085"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_1_1"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CGS_like"/>
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    </dbReference>
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        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA83956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="450" mass="48304" checksum="5C8DFB0CF0E886FB" modified="2013-06-26" version="1">MAGESSKKAAAAGKAAIPLDIDGHNLPPSPAPSSPRNGRKYALMTELVYTESSDQYNASSVPIYQTATFKQESGSGGGEYDYTRSGNPTRTHLERHLAKIMNANRALVVSSGMGALDVITRLLRPGDEVITGDDLYGGTNRLLKYLSTHGGIIVHHVDTTNPEKVREVVNNKTAMVLLETPTNPLIKICDIPAIASIAHAANPTAIVAVDNTMMSPMLLNPLDLGSDIVYESGTKYLSGHHDLMAGVIAVNDSALGDRLFFTINASGCGLSPFDSWLLLRGIKTLGVRMEKQQANAMRIATFLESHGFKVRYPGLKSHPQYDLHWSMARGAGAVLSFETGDVTISERIVESARLWGISVSFGCVNSLISMPCRMSHASIDEKTRKERNMPEDIIRLCVGIEDAEDLVDDLSRALVQAGAVNITTEGFRALGTEAPAADEPTEAVSAPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGP7</accession>
    <name>R0IGP7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase organizer 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_180227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028539.1">
        <property type="nucleotide sequence ID" value="XM_008030348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGP7"/>
    <dbReference type="STRING" id="671987.R0IGP7"/>
    <dbReference type="GeneID" id="19401746"/>
    <dbReference type="eggNOG" id="KOG0316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="35860" checksum="67FBA5E2F4F96914" modified="2013-06-26" version="1">MSFPATPIAKLTGHNGIVHAVAYSSGTQSYILTGSSDRTIRLYNPKNAPSNSVAPTQSSQRPAGLVNKYTAHGYEVLSIDVNEGNDKFVSTGGDKTVFLWDVQTAQTVRRWTGHSGRVNRGVFGGEGDSVVVSGSFDGTVRIWDVRSNAYKPIMTLSDAKDSISDVAIHDAEIVAASVDGRVRSYDLRTGMCQVDVIGPSCTSLAVSKKGTEVLVSSLDSTVRLMDRANGALLKTYKDDAFVNKDLRVRSTLGLNDSVVVSGSDDGMVFAWDMLEGTCLHKFKHSEMREMSDSAPNTQVKGKKDLVSAVAFCQTRREWCSGGGDGNVVVWGMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHQ5</accession>
    <name>R0IHQ5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_171762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
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    </reference>
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        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
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            <end position="150"/>
        </location>
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        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="439" mass="50590" checksum="91723882EF2563C3" modified="2013-06-26" version="1">MTANDWQYESYVQPAQVELYDDDPLPPPPPLHTIPQGPPPPMPPEQLHGSPVGKQTYNFAEIRRQIDELAKSREDLRGYRFRMQRERKEISNIREQTGSKEGSALNQLRNLLHRQSIAVPREIEEILEQIEALRDQLGALEAEYEDDERMYTRREIEYSEQEYDMVERLGDVHSHYSPQSDFQQNPANGGISRKSLAAVTDSRQLTPQYEDTDIAPSKKALQLVLQANLNYDVQDQIQNQEIDDTYTAEIELYANRDDVENWLCDMIFQSPLQQIERQNARQTNEPGPVSLLDQIPHDWYWIDSFGAQFHSTDLNRSHVTGKQQYFTISRPGFLSHRSSASVPRAILPKGPGLYAKRSLYQQPLVQIMSLRGSKSTGDVSLMRDQDAFSTVEIQHPQSCEMSRMYRRRSLSCSSIALEQSPALGRPKNFHENQRKPVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIU3</accession>
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        <submittedName>
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    </protein>
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        <name evidence="8" type="ORF">SETTUDRAFT_91778</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
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    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="Histone-fold"/>
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        <property type="entry name" value="TFIID_TAF13"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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    </evidence>
    <sequence length="359" mass="41282" checksum="40CE13D0B3CFD078" modified="2013-06-26" version="1">MSEKDKMAKYRTEIQQMMFVSGETGEPSPETTTLIESIVQDQVQHMLRECTVLATRRGSKSIATDDLFMLIRHDRAKISRLRHFLQWKDVRRSVKDSDDKGGDAGADVGAGDADIAAGVVGAGGPGAAPVDASKKAKRAKVDLVWDVQSFFTEIPPQKDDVEDEEEEEMNYATLQRLKNADERTKNMTREEYVHWSDCRQASFTYRKGKRFKEWAGFGLITDSKPSDDIIDILGFLTFEIVQTLTEEALKVKDAEDLYKKNHGGEQNRLKRKRERGLFDPPEEAREPVQPVHVQEAYRRLQRGNNKAKAMLNFTRNVHRSALKLVSTAQRACVRESVLTICRFRDKARRWSWHWIWRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IKA8"/>
    <dbReference type="STRING" id="671987.R0IKA8"/>
    <dbReference type="GeneID" id="19397450"/>
    <dbReference type="eggNOG" id="ENOG502SGBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_416880_0_0_1"/>
    <dbReference type="OrthoDB" id="5422351at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF1">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE GLYCOGEN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="413"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="77"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="856"/>
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</entry>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="PANTHER" id="PTHR42973:SF32">
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    </dbReference>
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    <feature type="chain" id="PRO_5004342420" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
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            <end position="486"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA85426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="486" mass="51755" checksum="2B4D0399BCF14092" modified="2013-06-26" version="1">MASRVVLSLLSLVGLTSAVTPGNIQSYLKSHLSSSAEVLLPSDPAYKTDLTERWNSYQAPSYVVGVKPSTAEDVATIVRYASQNNIPFMGTGGGHGYTTTTSAIKNGINIDLGGFKSIAIDAAANTMTIGGAVTFGDVLNPVYNAGKEIQIGSCSCVGMVGATLGGGIGVYQGLHGMIIDALQSVTLVTGKGNIVNASASENSDLFWGIRGAGQNYGIITSATYKLSDQTNGGQALNGDFLFPVSANATIFKILKSFAGKQPDALSLTTAIQYSPTLNTVVIMVNTVYVGAEKAGRDVIKPFLSIKALQSNVTMMPYNRLIKENRFGADALGCIAGLPEAAYGLNLYNFDVATYQETLAAYVDFYATTKLTTSFMVTEMFPTKVALSTPDAATAYPYRGTMAYLFMSFSGFSTDAQVSAISKFALERRAAFVKLNGAKGLQVYVNYAHGDEGRDAWYTAAKLPRLETLKGQWDPHNLFNFTNGFDY</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="318" mass="35685" checksum="B7BD4B66F60FBDC8" modified="2013-06-26" version="1">MGADEEPTRDEAGAVKFGPKTLKETLKELDAINKSIIKLDEENDPFDGLRKTLFRFLMIHEYSVDEPLDNTVKLPAVPTELISEIGVHLSSRDLQTLRYTSKRFRYGVKTIFGKELVNAQTVFPTYVSVASFLALLRCESFFPGMVDTVTLVGEAPRIHEHGSDWAWERLEDSERAVVTPGDRMLQRGINAAHAAWCSVNDDFCYSGGYRILLTMMLSRLPNLKTIKIRKLRAGEHVPDVDGMDALPDLSFYRPKLPVNDIFYGDWQYDTVHKRVTVYTDEYGEEIVEAGAGPQASFIDDVVAAMGNARTSAVLESIV</sequence>
</entry>
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    <accession>R0INI5</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA86336.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="62" mass="6278" checksum="BB7E4EC830D7086F" modified="2013-06-26" version="1">MYLATAPINTHGYSVQPQAPGSPAGEKGSKPQVSSFPTREVKSGRHDPLGGVAALSAGDDVS</sequence>
</entry>
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    <accession>R0IPY1</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="R0IPY1"/>
    <dbReference type="STRING" id="671987.R0IPY1"/>
    <dbReference type="GeneID" id="19402181"/>
    <dbReference type="eggNOG" id="KOG0236">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_3_1"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
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    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GCP_C_sf"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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            <dbReference type="Pfam" id="PF17681"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="3">28A</strain>
        </source>
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        <location>
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            <end position="26"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <location>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
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        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
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    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
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        </cofactor>
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        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
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    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
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    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
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        <ligand>
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        <ligand>
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            <position position="203"/>
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        <ligand>
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    <feature type="binding site" evidence="16">
        <location>
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        <ligand>
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            <end position="226"/>
        </location>
        <ligand>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
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    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022496.1">
        <property type="nucleotide sequence ID" value="XM_008024305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IY61"/>
    <dbReference type="STRING" id="671987.R0IY61"/>
    <dbReference type="GeneID" id="19405010"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF24">
        <property type="entry name" value="HYPOTHETICAL FRUCTOSYL AMINE:OXYGEN OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="433" mass="48498" checksum="72CC48E141FBDE1C" modified="2013-06-26" version="1">MPQTSHSNLLIIGAGTWGCSIALELARRGYTSITVLDGSSFPADISAGNDLNKIAEEANEPSESDSDEGYFWNRMTQLAMHAWKHDPLFSSFYHDTGFIMSAVGDAAYERCKEYARTEKTTPVALNSKEDFQCTMPKDVLQGEFPGWRGFWKKQGAGWVFASGALRAMHNEAVRLSVSFVTGDAGKVQELLYSLDKSVVLGARVADGAEYVAKHTILAAGAGSDLLLDFEKQLRPTAWTLAHLPLSAEEAEHYRNLPVLYGVDRGFFIEPDMENHEMKLCDEHPGYINPVISNGELRSVPFARHQIPKEAEARMRCLLAETMSQFAERDFSFARICWDTDTVDRVFLIDRHPKISSLIVAVGGSGNGFMACPAIGMLVSDVFEDKCETRLRETMRWRPEISIDRDWWDAQGRYGAHEKVMDFRDVDEWTTIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0T0</accession>
    <name>R0J0T0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_25646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021843.1">
        <property type="nucleotide sequence ID" value="XM_008023652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0T0"/>
    <dbReference type="STRING" id="671987.R0J0T0"/>
    <dbReference type="GeneID" id="19402930"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000331">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF187">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="18"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="438" mass="49018" checksum="9F2FB749C6CADD15" modified="2013-06-26" version="1">MSSLEINGNDAAPRTGIKVIIIGAGFGGLSTAIECIRHGHTPVIYESFPELKILGDIITSGPNAGRIFARWSGGRIAREMRKVSIDLTNYGFNIHKWDTGEIVLNQKTPPRDETAPNFNGHRGELHEIVFDYAREIGVEINLGHRVEQYWENDNEAGIVLEDGTKVTGDVVVASDGVRSKARTLVLGYEDRPKSSGYAVWRAWFPNKDMIADPETKHFCDNGDTFNGWIGPDVHFLFSTIKNGSDCCWVLTHRDSHDIDESWSFPGYLNDVRTVLEGWDPMCWKIVSKTPEEKLVDWKLVYRDPLPNWVSGYGSAPGHGRICLLGDAAHPFLPTSAQGATQALEDAVTIAVLLRKAGKENVKAALRAYQDVRYERVKAVQKTGETTRDRWHKTDWEEVKKDPTLIQFPREDWIFLHDAQKHAEEVGDEAIKKAGSVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0J227</accession>
    <name>R0J227_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WDR59/RTC1-like RING zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_101874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021688.1">
        <property type="nucleotide sequence ID" value="XM_008023497.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0J227"/>
    <dbReference type="GeneID" id="19394890"/>
    <dbReference type="eggNOG" id="KOG0309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001497_3_0_1"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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                <person name="Grimwood J."/>
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                <person name="Han J."/>
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    <sequence length="104" mass="11389" checksum="E955462604AC55FF" modified="2013-06-26" version="1">MLRTSIIKSARAIAAPRYFSASALRLTEGATGSGASRPTGMAGGDAFTKREAAAEELYIRQEEKAKLLGIKEKLRQQKKHMDELEKHIDDVIKESEASGQGEQK</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA80748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="168" mass="19105" checksum="2311F9871A46C244" modified="2013-06-26" version="1">MNRFRAGVPITRSLWKRTAIQTRPARRQVQQRDFAAETQPPPPPRKEPSRAGAYYGTFGSPLLKCFLGALFTYQLAYYLWYKLETIEEQHETRSEIAELQEELRQAIEKQRHFAQEKLGHAAEVVQREKHELGEAVDAVVAEVKEGADEVGKGTKAVGKVAGGGWWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0JHM7</accession>
    <name>R0JHM7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_157872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031491.1">
        <property type="nucleotide sequence ID" value="XM_008033300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JHM7"/>
    <dbReference type="GeneID" id="19397768"/>
    <dbReference type="eggNOG" id="ENOG502S625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037244_0_0_1"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353501" evidence="3">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA80898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="385" mass="39305" checksum="199FBC52F76B31E5" modified="2013-06-26" version="1">MRPSVGLVGLLLVAAPAVLAQAQNPPNQPRPDGTTTSTTQPVQPATTTSEKTTQPATDPPKPTQPATSETSTSATTTVAQTGSTSVFNLAGAPTLAGVGVPVQQVPNTAGAPFMQKSNLPDGTVFICVGAVLAFFGAALLVWRALVAWSLHRSVKRAAMTQNMTDIKTMAAMPTGKRGMYNVVGANSTMSLDRLNGAPVGRSVKPSAAAAGNGPQRPLSSLFFSPTAGGAAGMRDSMVNRSSTYLPAGYYAAGSSVAASGSPQTHIGGQPHHNISALSLSSPGNRFSTRSGVSPPESPSLPPSRGGYPRPPPSREGLSVYNRNSMATLNTPGNTRSGVFGQDNNVSQLSLNVPGGTNVPGGRTPSGYLDDLFENHGTGNGGNARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JHZ5</accession>
    <name>R0JHZ5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_35885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031258.1">
        <property type="nucleotide sequence ID" value="XM_008033067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JHZ5"/>
    <dbReference type="STRING" id="671987.R0JHZ5"/>
    <dbReference type="GeneID" id="19404064"/>
    <dbReference type="eggNOG" id="KOG0397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA80998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19865" checksum="09E7714E95986B64" modified="2013-06-26" version="1">MTDSKASNPMRELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRKRNFSESGNFGFGISEHIDLGIKYDPSIGIYGMDFYVCMTRPGERVAKRRRCKSKIGPSHRVNQAETIKWYKNRFEGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0JID8</accession>
    <name>R0JID8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_59177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031318.1">
        <property type="nucleotide sequence ID" value="XM_008033127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JID8"/>
    <dbReference type="GeneID" id="19405245"/>
    <dbReference type="HOGENOM" id="CLU_115009_0_0_1"/>
    <dbReference type="OrthoDB" id="3939900at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA81098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13577" checksum="B3179EBC823067AD" modified="2013-06-26" version="1" fragment="single">LPQELLSEICAYLPADGLVALKLAHRILDAQVQINPWAWSSGQISQCARVAIRTYLAPPDSARKQQWCTLCHRNYPASMFCSSNSPICTRRSLIQQESEVEVLKLPPRMCCWHAGRLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJA0</accession>
    <name>R0JJA0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SETTUDRAFT_157349</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">28A</strain>
        </source>
    </reference>
    <reference evidence="27 28" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030894.1">
        <property type="nucleotide sequence ID" value="XM_008032703.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0JJA0"/>
    <dbReference type="GeneID" id="19397725"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="26">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="820"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="1072"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1576"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="471"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="775"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EOA81418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1706" mass="194338" checksum="640CD5882DB922D6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLN5</accession>
    <name>R0JLN5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_165594</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
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        <property type="protein sequence ID" value="EOA82128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030435.1">
        <property type="nucleotide sequence ID" value="XM_008032244.1"/>
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    <dbReference type="GeneID" id="19399524"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_4_2_1"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0071897">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
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    </dbReference>
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        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="611"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="842"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA82128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="884" mass="97860" checksum="F8DBCCDC6212EB8D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0JRG8</accession>
    <name>R0JRG8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_164163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028222.1">
        <property type="nucleotide sequence ID" value="XM_008030031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JRG8"/>
    <dbReference type="STRING" id="671987.R0JRG8"/>
    <dbReference type="GeneID" id="19399017"/>
    <dbReference type="eggNOG" id="KOG3894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047847_1_0_1"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="238"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA83708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="328" mass="37045" checksum="E210E162D24F21C5" modified="2013-06-26" version="1">MFRVEALDDFVKEAYRIRTHITKLHTDLKSIRQSYLSTANPPRRKQLARTNTATDKDTKYLSDAQRNEIDIQAKQSIHQLNDAIKRLGVAEQARQAAQSQLALRRRAKQGLGALGRWAAGGAITAKSPEEEIEEAKANTIKAHRESIIWSLQKQLEQCGRFQSDMMEIRLTREVEKSKSVLYKTRTTGPSTMGYGTGADSTDYRDKASYRPDETDAVIEQQLDAEQLQLFAQENQDMLKQYEDQLDKVRATEKSLTEISELQSTLASNLSMQAAHIDQLVEDSLNTRDNVGSGNKELKRATERGSTAQKVFWATSVFCAGLVLWDLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0JSD0</accession>
    <name>R0JSD0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_172561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028428.1">
        <property type="nucleotide sequence ID" value="XM_008030237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JSD0"/>
    <dbReference type="GeneID" id="19401187"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA84003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="545" mass="61063" checksum="BD60062670613920" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JSY9</accession>
    <name>R0JSY9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_93623</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028549.1">
        <property type="nucleotide sequence ID" value="XM_008030358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JSY9"/>
    <dbReference type="STRING" id="671987.R0JSY9"/>
    <dbReference type="GeneID" id="19406046"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="244" mass="27721" checksum="88607E9645595790" modified="2013-06-26" version="1">MMASQNDEDPFLQVQADVLSALNNARPLFKSYLRIRSSASSANSPELREARSELEQTLQDLSQDLEDLVESVKAVEHDPYRFGLEIDEVERRRTLVKDVGYEIENMRDELQQTVQHAKNKGKNAANGGDMLPDPDTFEDDDNYAAFEQERQMEMMHEQDEALDGVFRTVGNLRQQADDMGRELEEQGELLTDVDNIADRVGGKLQTGLKKVGWVIRKNEDSWSSCCIGVLIFVLILLLVLLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0JT50</accession>
    <name>R0JT50_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_35625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031235.1">
        <property type="nucleotide sequence ID" value="XM_008033044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JT50"/>
    <dbReference type="STRING" id="671987.R0JT50"/>
    <dbReference type="GeneID" id="19404041"/>
    <dbReference type="eggNOG" id="ENOG502SRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831567_0_0_1"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="30"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA80699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="343" mass="38760" checksum="BE6CB046672CD8D9" modified="2013-06-26" version="1">MSSSMTSSSLFSRARAHTAVMPSPKKLRGFLALPGEIRNGIYSYYFGSEYHCEITAQGSQFKQRRPHTIKLWSGLAARKDHASRPDTKPGMPALNIVRFSGPLGLQTNWLGSPYALSLTCKQVHLETAAFLYSKTVFIFDAPKRILNFFNVVPSTSLDKITKLHFHYDTYGPPHRADHQVWQAKHSQSWFNACKAASKKLTGLQELQVWAQLHDSAPKFSLREKWITPLLQFQRHTRCTSRMKAVDDAAAATASPKANDTHTSYLENVQVHIRTRWSHSPLTAFLNNKRLAQASTELHVLYGHAVSLAIKGAKEEEAMAAFDAAWGGKYRQWRHHLQFAQTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0JTG8</accession>
    <name>R0JTG8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_33355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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            <strain evidence="11">28A</strain>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">28A</strain>
        </source>
    </reference>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19398925"/>
    <dbReference type="eggNOG" id="ENOG502S65B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4157259at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="163" mass="17947" checksum="C7761D4CB63314AB" modified="2013-06-26" version="1">MASSSNAIAIPRRKDKHPAASRHSVDSSSSSAASTPSTPSYNPNPRNYHFSPTDSRFSYRGYGGGESSASSPGTSPLSASTMRRRESLMSATFSKAEHTVINVGEEECPRLITCVKASQGFDWNQEIFLPSYADYHFDDLECRQDPVQDIILTDEEIKNMFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWE8</accession>
    <name>R0JWE8_EXST2</name>
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            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_32494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWE8"/>
    <dbReference type="STRING" id="671987.R0JWE8"/>
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    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="Fun_TF"/>
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        <property type="entry name" value="Sterol_Uptake_Regulator"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="387" mass="43104" checksum="979906E1A905B34D" modified="2013-06-26" version="1">MDRAKTRKSHKKSRNGCLPCKGRHVKCDEQKPNCTNCVKQGTAYEYRPPASSEASHTSPLPGQQLLPRLGAAANTASAGTGLALNIPQLRLLHHYMTATAKTLAAHTDAEDVFKTTLVEIAFEHPYLLQATLSLSALHMSRLVRPEEAQEYLIQAQEYREAALDDFHNTVRNIDESNFKAVMLFTGTLFPHACITSIAASNDLDYAFESVISNLVVTRGVRPMIMGFYAQMKTMSKTLSFIKKSHGPIQSLFSSTNSQTSSITYTPPDIVDAYKHACHLLEVIFQVAAESSKSPSDALLKTWIHLVSERYIELLSQKQPGALIIFAHFAVLVNRASKHYWYIEGLAEQIIRVAEHMVPSEWGSWLQWPREQILGIPGHPMPSPGYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWV3</accession>
    <name>R0JWV3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_35656</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EOA80732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031240.1">
        <property type="nucleotide sequence ID" value="XM_008033049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWV3"/>
    <dbReference type="STRING" id="671987.R0JWV3"/>
    <dbReference type="GeneID" id="19404046"/>
    <dbReference type="eggNOG" id="KOG1721">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013258_1_1_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000978">
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="564"/>
        </location>
    </feature>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031685.1">
        <property type="nucleotide sequence ID" value="XM_008033494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JY85"/>
    <dbReference type="STRING" id="671987.R0JY85"/>
    <dbReference type="GeneID" id="19399835"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_0_1_1"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
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    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA81187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="324" mass="36139" checksum="65C49DF605D53B77" modified="2013-06-26" version="1">MALIDRVPGDLNLYIGGMFTLRRREALEQANITHVLSVLRTPLDRDLFAPFAHMVVEVDDVDDENLLEHFPATNRFIRDGLHGGGGVLVHCAMGKSRSATVVIAYLMQEHNISPSEALSHVRQARSICEPNPGFMKQLDLYADMHTPEDVENTPAYQRWVYQREIELSRACGQAPGADKIRFEDEHVADEASSFELRCRKCRRALATSQYLLSHGSSVNAKDSEAQVPASAKCAHYFIDPLSWMRPELEQGRLDGRLECPKCHTNVGKYAWQGMQCSCGEWVVPGISLAKGRIDEARKATFGIRRPPGAPVQPPLGAPHSRENL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
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    </dbReference>
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    <dbReference type="GeneID" id="19402482"/>
    <dbReference type="HOGENOM" id="CLU_1384932_0_0_1"/>
    <dbReference type="OrthoDB" id="3810729at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="197" mass="21520" checksum="381B619453AE7D36" modified="2013-06-26" version="1">MAKKYAARMSLDIFKRAASTFHMTLTALRTREEEPRVALTSSILMSPGYTAFAHQIVAVTELYIDAFRPKRGGILADEMGSGETHTVLATFWMNMLAVAQIHSGIPNLEFPPMSSGAVNGVPPRVGATFISASPQGLKVWPQAYDGASYASYAQEFGGEEKGIYSSMSANEWAEILPQPDWTRSRAPIQPPHHTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0K173</accession>
    <name>R0K173_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_88198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025466.1">
        <property type="nucleotide sequence ID" value="XM_008027275.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0K173"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <location>
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            <end position="61"/>
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    </feature>
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        <location>
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            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA86908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="325" mass="36093" checksum="67C518007AD4A25A" modified="2013-06-26" version="1">MLSSWSTSLNLIFLSVAWTTIAASYSPLQLELVAPLVLRLSLYIIPSLAFLLFDIGVPSLAVEFKSQGKWGIPSNQKGGAKVVRRVVAWSCANVLLTVVLQAGIEFLVTDVLRMKSLLLIKGSRWGLNHLPNPWIMVKHGIIGLVSRNVLQYYIHTHLLHSPTGGILSDLHQSWHHSIRIPYSFAANYDHPICHLLHRFVPLYLPAIALRMHILTYLIMVGLFSLEETFVYSGYNVLPSTIMLRGMARRADAHMMSEGEGNYGCLGVMDWFHDTTLGKDVVEDLKAEMDKHNVEAKAGKAFETAGDAANGFAGKFGRSKKGKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
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    <name>R0K1R6_EXST2</name>
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            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">SETTUDRAFT_120466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="15"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="189" mass="21148" checksum="F2EE46E1FF47DEC4" modified="2013-06-26" version="1">MFETGTARREIDECTEVPKSTNPYVKLLVRLYKFLARRTDAPFNKTVLRRLMMSKTNRPPVSLSKIVSIAANKNTAKTHEGKTIVIVGTVTDDNRMLELPKLSVAALRFTASARARIEKAGGECLTIDEVATRSPTGANTLLLRGPKNSREAFKHFGFGPHSGKKPYVESKGRKFERARGRRRSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3L0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_169070</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908581">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026669.1"/>
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    <dbReference type="AlphaFoldDB" id="R0K3L0"/>
    <dbReference type="GeneID" id="19400776"/>
    <dbReference type="eggNOG" id="ENOG502S5KA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2428440_0_0_1"/>
    <dbReference type="OrthoDB" id="2589819at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025494">
        <property type="entry name" value="DUF4385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14328">
        <property type="entry name" value="DUF4385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="91" mass="10867" checksum="34DD3675AD67E867" modified="2013-06-26" version="1">MDMSRKFLQMGMTRAKRYANHAGGKKYDKNTGEKLDKSKGHKGMKEKLEASEVFKEVWERAKMHDGYVDKKERFLKEQKEWDKARRRGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3P9</accession>
    <name>R0K3P9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_39178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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            <end position="160"/>
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    </feature>
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    </evidence>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
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        <source>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025948.1">
        <property type="nucleotide sequence ID" value="XM_008027757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KA66"/>
    <dbReference type="STRING" id="671987.R0KA66"/>
    <dbReference type="GeneID" id="19400783"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA86319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="365" mass="41008" checksum="340E04EB4ED3436B" modified="2013-06-26" version="1">MAPQFEPMKNNLILRTARGEKVERPPIWVMRQAGRYLPEYHKEKGNNDFFECCRSPEIASNLTLQPIDRYAGLIDAAIIFSDILVIPQAMGMEVIMVDKKGPHFPDPLQTPDDKQYKEVLERKVNVAESLDYVYKAITMTRQKLAGRVPLIGFCGAPWTLLCYMVEGGGSKMFIQTKTWIYKYPEQSKALLEKIAELCVEYLALQVQAGAQMIQVFDSWAGELSPSCFKTFALPYLNHIADNLPERLRSKGLEPVPMTVFAKGAWYALSDLCETNYNTIGLDWLHAPAEAYKVAQAKGKVLQGNADPGVLYGSRESITKAVEEMVAGFGGGKQGWIANLGHGITPFVKPDDLKFYFEEIHRLTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAK9</accession>
    <name>R0KAK9_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_169223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026060.1">
        <property type="nucleotide sequence ID" value="XM_008027869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAK9"/>
    <dbReference type="STRING" id="671987.R0KAK9"/>
    <dbReference type="GeneID" id="19400831"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LEC1-like"/>
    </dbReference>
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        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="208"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="966" mass="109715" checksum="04FB8E0D33C470D2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBS2</accession>
    <name>R0KBS2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_162978</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025426.1">
        <property type="nucleotide sequence ID" value="XM_008027235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBS2"/>
    <dbReference type="STRING" id="671987.R0KBS2"/>
    <dbReference type="GeneID" id="19398611"/>
    <dbReference type="eggNOG" id="KOG3255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_1"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="193" mass="21884" checksum="EA8D3D73B90823A9" modified="2013-06-26" version="1">MKYIHSEEELTIPDGVKVNIKNRYVVVEGPRGKLTKSLGHLAVSFTHPKKNVIKIELHHGSRKSVATLRTVRTLINNLIIGVTKGYKYKMRYVYAHFPINVNLEKNSETGCWEVEIRNFIGEKLVRRVVLRPGVDVEASKSQKDQLELSGNSLEDVSQGAADIQQICKVRNKDIRKFLDGLYVSERGNIVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KC73</accession>
    <name>R0KC73_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_103304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022339.1">
        <property type="nucleotide sequence ID" value="XM_008024148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KC73"/>
    <dbReference type="STRING" id="671987.R0KC73"/>
    <dbReference type="GeneID" id="19394978"/>
    <dbReference type="eggNOG" id="ENOG502SSB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046870_0_0_1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA90518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="363" mass="40502" checksum="11964B3E10AD975B" modified="2013-06-26" version="1">MTSISKDQFYQAAYPLIVFTSLFVFARIGIQIWKRRALELQDYLLYAGFVLFLAMSICYVIVAPVIILMDKVNEGQIAPWPDMMADVVLCIRMSFVTTGLFWLSLWSVKLSLLALYKKLMNGLPAVYMRLWWAVLTFCIVGLVGCFVSYATSCPDIIATLSMGDCPKNERSVRGQLACLYASYAVDIASDFMIMFLPIRLVWNLRIARGQKIAIIALFASGLVCIAFATLRVVQIGDTAGTNKFPSPAWIALWTIIETSVALCIGCGPAFAVLYRSTQTPHVSSDRHGYFQHPRNGSREASNNLNAIKMRSVTVSTSRKTPSKPNTWWDDTKSSQEELAAESKRITVTTTLEQEYRGSAANEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCW4</accession>
    <name>R0KCW4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_166659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Turgeon B.G."/>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <begin position="17"/>
            <end position="204"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="214" mass="23259" checksum="8DF73FF99BC588B4" modified="2013-06-26" version="1">MHDPIADAKAQEATRRYEFRAATRADIPALQQMIGDSLRALGKGYYTQAELDGSIGYLFGPDSVLIHDETYFILHPVSQPEVICACGGWSFRKTLYGGDSAPSLLRMPEKRDPAVERASIRAIFTSPAYARRGLGTMMMRYCEQQAAAGKAGETAGFSRLEMGATLSGVALYERCGYVRSGREDAILCPNGAQIRILHMTKDVKDGEDADGGAP</sequence>
</entry>
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    <accession>R0KD87</accession>
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            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
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    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_166782</name>
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        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0KD87"/>
    <dbReference type="GeneID" id="19399922"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343242" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA90883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="449" mass="49092" checksum="235A93F43845654D" modified="2013-06-26" version="1">MKFPSALGALGASSLLLAGVGAVELDINSPDSIKAAAKALALNMRSYYTGDRPGDVAGNLPDPYYWWECGAMFNAFIDYWYYTGDETYNGITTQALQHQMGDDGTFMPSNQSRTLGNDDQAFWGMAALSAAENKLPDLPDGQPSWLELAQAVFNTQYKRWDTSTCGGGLRWQIYTFNNGYNYKNTISNGCFFNIASRLYKYLGNQTYADWAEKVWEWERAIGLMSPDYHFYDGTDDTQNCTSINHIQWTYNAGIYMSGAAAMWNATQSDIWKTRLQGVISGIGVFFQDNVMTEVACENNGKCDVDQRSFKAYLSRFMAYTAAVAPWTRPQLDPLLQASAQAAAKQCIGGVNQTSCGLRWIDGGANDGSFGVGEEMSALEVIQSLLYPTKEGPVTEKKGGISKSNPNAGNTASDAPIVFDTVTTGDRAGAGILTVLVLVTILVGAWWMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDA8</accession>
    <name>R0KDA8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_101410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021609.1">
        <property type="nucleotide sequence ID" value="XM_008023418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDA8"/>
    <dbReference type="STRING" id="671987.R0KDA8"/>
    <dbReference type="GeneID" id="19394854"/>
    <dbReference type="HOGENOM" id="CLU_1010315_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="276" mass="31043" checksum="EBD63D3DAB2FBD55" modified="2013-06-26" version="1" fragment="single">RGHIFRKLAPAVGPGLAAVLPNLRSFYWEFGEVDDTSINVESRASFAKMLEQTRLDKCSAAEITFHPDPPADHRVAEPSRIPTGALYDPLSASLRLFLQTLTSLVLDGFVDSTLFWPSSLETSSMPSWPALRKLMVLFNMAAPSGEWYFDGTPGEIEEQFRHHADARTLGPFVTAFARAVQNMPVLEHFLIETELGYDTGYWDISYHAPGIQADGDENDDDAKLRRVYYSVGETWRPDAFVAEAFRGLGRDTHGPALIERFQGLRTWALESPWSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDV2</accession>
    <name>R0KDV2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_169112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025963.1">
        <property type="nucleotide sequence ID" value="XM_008027772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDV2"/>
    <dbReference type="GeneID" id="19400791"/>
    <dbReference type="eggNOG" id="ENOG502SJ96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052363_0_0_1"/>
    <dbReference type="OrthoDB" id="5283561at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="55055" checksum="F03727C6144AFC07" modified="2013-06-26" version="1">MHLNDFPYEILAQILHEVTKANVREGPTYTFGLQQAPLPLERAKLQRYVRGPVPPELLKWDATATLRSVCWKWHEWALEHSLKDVYIRRWKGGERWAELSNRRESYPLYELIDRPTGTAVYRDPFASLKRTVKICNDYPQVASKVRRMWVHGFYTAETDRMIFESLKNCTNLTSLSIPWTTIRHVDAKAWRTMLTGSGKSLESLELQCVDPTSQQATDKDNLVDLEPLQSVNFSQLRRLKIFGDTSFMPITDNDLFAIARTATQLEEFHLTCNSSITIDGVMAIVKASRKTLRVLEHSPRSQDGFWHPHPGSPSDSEHLCDTFRNCPKLETLSISLPSVCSHLFSNEDAKFAGDLQVRALHLCEHEHGRSTHEATDALQKLLEQARRFIRLRAESAIPRELYIELFFADCIFEPGFEAVHGDFSLAQISSEGHWPQNVDFSGKGPYGSTGLYGKEEEAQFQRIDEAEFLAGVHRRLHSIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEB5</accession>
    <name>R0KEB5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_170198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020525.1">
        <property type="nucleotide sequence ID" value="XM_008022334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEB5"/>
    <dbReference type="SMR" id="R0KEB5"/>
    <dbReference type="GeneID" id="19401026"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
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                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="381" mass="42942" checksum="59704822FC5D803A" modified="2013-06-26" version="1">MASPPPLETFTNLPILPLSAALSPDTKPQFLADLRSALLHVGFLYLTDTGLPDDVVHGVVRECVAFFDTLPLHQKERIEMKNEKSFLSWSRVDNETTALNPDHREQLDLSTPHPVPGPDAPIYHNLLAPNQWPSPDYLPDFRPVYEDYIRRMSHIATLFTSLIAEAIGLPPTAFDKFFDPDQQHKLKIVKYPEVHVPDLPPGATEMERKKWEVKRQGVGPHKDSMLTSYLLQASNQRGLQAQNARGEWIDCPPIPGTLVVAIGQGMEALTDGVCASTTHRVLSPRKGEGARYSVPFFQGVSYDARFEAMDVPDEVVRLRDEARKQPRDDVEFTFVKGRWGHLGEATLMNRIKSHPDVGERWYAEQLKQIRGQQQAAMVTRA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37758" checksum="B9C796CE04C74CA0" modified="2013-06-26" version="1">MSAPNLLTIPVELRELIYGFLFSSYTIRHGFKHPRAPSTDDESLNRTSLLLTCRQISIEASRHLPLNCTIHFRGTENLLETLLSIDQSVLTRLRHIRVRAYPFPLYPAQTTQYYPAYYAANALTLLPGLCLDTLVVEDCWHGFGMGDGWRDVTTYFDIESLLNSDAWRELTYITPCTDFIASGYDHRSKRSAQPETWDALIKERDGAEYGAEVKMFIVPYDQTTATGSARTPDGRIMQPWAAKPGNEVIQNWRIAGPEQDLKGEVRIIAKRGARSRAVQLGLSEKRTWKELKGKASGSFAPEGWTPYHNDMADAVGWIYGGYGRRMQLADAALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGS0</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_149057</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="R0KGS0"/>
    <dbReference type="STRING" id="671987.R0KGS0"/>
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    <dbReference type="eggNOG" id="ENOG502QQSQ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF1">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="467" mass="51153" checksum="4EF8276FA8FF31C9" modified="2013-06-26" version="1">MVSSNYSNVPTPVPFPQPDDIDNEDASTPATRKRSSTSASAMSNRLRTATGRLMEASPPPGMWAATGHAVAKAPSLKDIRTGSFGSDGWNEHAQRSRAGSRASRSTAATTTASSEQTDRPRGAARKTSSINILASETFPAVAEEDAHHEAQHDGQHDSTAAGMQPKQSGEKAAEPIHHDRPHTPKRTSSGHYANGYVPPPKLPWTQAFAIGLRSFWKWFLTPLGFFITLYGLNVVAWGGMLFLLLCNAAPAMCKPDCNDINSPRRKWIEIDSQILNALFCVTGFGLAPWRFRDLYWWGWWRISGPKRRVTGIRRLAGIHRGWFRLPGSDELPDDADATVVDPKNPAVPIPVTAIPDPPPTAIRAPPTRSWTMDLVVWFNVLNTLLQVLLCFYMWHYNRINRPSWATGLFVALACIASGIAGIVTWQEGKQVKKFEGVPVTKDYKDEAKDAEASAGIPLVTAGVAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KI10</accession>
    <name>R0KI10_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_168102</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023521.1">
        <property type="nucleotide sequence ID" value="XM_008025330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KI10"/>
    <dbReference type="STRING" id="671987.R0KI10"/>
    <dbReference type="GeneID" id="19400424"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_0_0_1"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000300">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="891"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="944"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="897"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="979"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA88869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1071" mass="120195" checksum="A134CDACDBEDEE1F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJ12</accession>
    <name>R0KJ12_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic phosphate transport PHO88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_167713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022990.1">
        <property type="nucleotide sequence ID" value="XM_008024799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJ12"/>
    <dbReference type="STRING" id="671987.R0KJ12"/>
    <dbReference type="GeneID" id="19400277"/>
    <dbReference type="eggNOG" id="KOG4554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
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    <comment type="subunit">
        <text evidence="3 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
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        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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    <dbReference type="PANTHER" id="PTHR12949:SF0">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="505"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="679" mass="76766" checksum="649FA9304F713B02" modified="2013-06-26" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
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    <dbReference type="eggNOG" id="ENOG502R8Y8">
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
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        </location>
    </feature>
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        <location>
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            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="225" mass="23254" checksum="CA004BAA59C71919" modified="2013-06-26" version="1">MAQDNLLTFLYLDLLGIGVSTLVFVASDDIATTYENYCPPTPTLSTPTPAQTAPSHLSAPQELPRPTFCANFTMFQGPSTWGLNRTITRSNLQTYNGDCTWTGSGAFTAVPITCDADAKGEMYGREFSRGTPVTFQPSELSAKTNGFGFAVATVVSGTETGTTGSSMVRETGEGNGGEAEATGTGTQGMGTQTGSQAMAGRAPFPTGVVAMVGSAFVVGAAAWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Barry K.W."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022523.1">
        <property type="nucleotide sequence ID" value="XM_008024332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNN6"/>
    <dbReference type="GeneID" id="19400155"/>
    <dbReference type="HOGENOM" id="CLU_2729358_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="72" mass="8598" checksum="33FAB88EF331595F" modified="2013-06-26" version="1" fragment="single">MMRRQHQEETHQRALEYLAKRPITMQHLNDWRRRFENGPEDEDEDEADHPPSPPPPPEPRQTAPNLRPVIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPS6</accession>
    <name>R0KPS6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_166883</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021698.1">
        <property type="nucleotide sequence ID" value="XM_008023507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPS6"/>
    <dbReference type="STRING" id="671987.R0KPS6"/>
    <dbReference type="GeneID" id="19399963"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="309"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA91029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="443" mass="50118" checksum="692D882B47407BC7" modified="2013-06-26" version="1">MSWKRSERLMETIKHYSKFPATGVSLRQMVQFGEKPSTGTLFRASQFLSEELPIRLAHRVQELTELPDGLSEMPSISRVRDWYAQSFEELVELPRPTLSSEVKERLLKPAKSSGDKSLMSKATQNPSIRTGQYRSAPATNGNGNGNGHGITREVKGASRRYYAAADDGLDWPPELGAYNRKFADTLEKIKRRHDSVVTTVAQGILEWKRKRQRMQIDHNIQAFLDRFYMSRIGIRMLIGQHIALTDQRARTDPNYVGIICTKTNVKELAQEAIENARFVCEDHYGLFDAPKVQLVCNPDISFMYVPGHLSHMLFETLKNSLRAVVERHGQEKEDFPVTKVIVAEGKEDITIKISDEGGGIPRSAIPLVWTYMYTTVDQTPSLDPDFNKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQ58</accession>
    <name>R0KQ58_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_112185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908498">
        <property type="protein sequence ID" value="EOA89992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022378.1">
        <property type="nucleotide sequence ID" value="XM_008024187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQ58"/>
    <dbReference type="GeneID" id="19395541"/>
    <dbReference type="HOGENOM" id="CLU_2910564_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="62" mass="7452" checksum="4AB5C8C0163E16DA" modified="2013-06-26" version="1" fragment="single">VNNKILHHENTNLREVLAIKNYLKKQKKPLELQQSKQYYTPAVVWSPRTIEDARAQERQKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQG9</accession>
    <name>R0KQG9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxidase</fullName>
            <ecNumber evidence="11">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_158705</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KB908493">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0KQG9"/>
    <dbReference type="GeneID" id="19397857"/>
    <dbReference type="eggNOG" id="ENOG502QT8W">
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    <dbReference type="OrthoDB" id="2113341at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Haem_peroxidase"/>
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        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
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        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF48">
        <property type="entry name" value="PEROXIDASE 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
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        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006993983" description="Peroxidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="12">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA90072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="295" mass="32369" checksum="DCEC5809375639D4" modified="2013-06-26" version="1">MRFSPIPLLAVLAATPILAEELAPRYDACPPVWKDVVNYLKPKFSGCSRSAHKIIRAAFHDCINNGCDGSLALSDERTHPENQGLQETCELVVDLKKRFSVSAADAIQFGAALAIASCPLGPRVRALVGRHDHSQPAERFSVPSSRDSVNKILVAFDKHGLSPRDVVALLGIHSAAFQEFDIPSLGVVALDSTPYIDDMRYYQETIAGTAPHSLQSDRLMTKAPQTKDAFAEFASDAYAWNKAFVEAFGRLSTIGNEHVKFTDCSHLIPNSPPVPRKRQIQNLKFTQKLAEKFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQX5</accession>
    <name>R0KQX5_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_25478</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021832.1">
        <property type="nucleotide sequence ID" value="XM_008023641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQX5"/>
    <dbReference type="GeneID" id="19402919"/>
    <dbReference type="eggNOG" id="ENOG502SA6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085124_0_0_1"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019240">
        <property type="entry name" value="DUF2196"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03833">
        <property type="entry name" value="YwbE family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069:SF1">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="228" mass="23927" checksum="C8232B58D283AA86" modified="2013-06-26" version="1">MQTGRRGHPNRQPRSSDRGGRGGRGRGQARGGFSDRARGSNTSRGSFRGHSSSSAYTPVPAYASIHAGGAVAIVLKQDQPTGHRVSGIVADVLTRGDHPRGVKVRLRDGRVGRVQSLVSEAEGERGEALVGGAGAGLGRDGEAGGARARIAGGRMERDIRDDNGYLFDESKCVNVADTGLFAALEEADRRHEERWAGGAADSAVCPVCGDFEGDEMAVARHVEGHFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0KT18</accession>
    <name>R0KT18_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_166833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA92022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="196" mass="21521" checksum="7EF966F410B91BC4" modified="2013-06-26" version="1">MTRRTVYAAGLALTLACTVMTIASISMPRWVSYSPNGEREYSYGLHTRCSAVTGTCVPFPKSSDCTKDPSFCNMWRTVGFLTSFGVVVELCAIVAFVVIISGGVQRRAAGWQVAVGVLSFSALVQCAAMAIVAFLFDHDERFWKGWHLDLSWSLCTASWTMLILTSIGMAASAFYLPNEGEYELIPEDLYGPPDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KWB3</accession>
    <name>R0KWB3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_162570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020999.1">
        <property type="nucleotide sequence ID" value="XM_008022808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KWB3"/>
    <dbReference type="STRING" id="671987.R0KWB3"/>
    <dbReference type="GeneID" id="19398438"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_3_2_1"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="200"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA92027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="588" mass="65205" checksum="7E96B9D08E2DD8EC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5F9</accession>
    <name>R0I5F9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_181982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031431.1">
        <property type="nucleotide sequence ID" value="XM_008033240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I5F9"/>
    <dbReference type="STRING" id="671987.R0I5F9"/>
    <dbReference type="GeneID" id="19401882"/>
    <dbReference type="eggNOG" id="ENOG502QS3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003963_1_0_1"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6X4</accession>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
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                <person name="Condon B.J."/>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA81506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="262" mass="28806" checksum="214358E667B8B2D0" modified="2013-06-26" version="1">MGKPPNLYAFQGTAELAPSLRTYVLDAQNAALERHHVFRVAVSGGSLPKTLAQALLKETNGEGRIQFDKWEIFYADERAVPLDHEDSNHRLVKEELLDKIPADLGTPKVHPIDVKYLDDVQELADQYEKTLVSVFAARDSVKLPLFDLLLLGCGPDGHTCSLFPGSDLLRETEAWVLPISDSPKPPPKRITISLPVAQHGLKIAFVATGAGKKDIMRKIFDTDEGQQLPCGLVNLKGADRVSWFVDYAAIEGVAFPARRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0I825</accession>
    <name>R0I825_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_23965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030622.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I825"/>
    <dbReference type="GeneID" id="19402723"/>
    <dbReference type="HOGENOM" id="CLU_1661876_0_0_1"/>
    <dbReference type="OrthoDB" id="3688570at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="159" mass="18515" checksum="2F676EC549E5AC48" modified="2013-06-26" version="1">MTQRFRLEHDPYHDSCISSDVGVLHHKSEHHIKRKAHSNTYTKPRRSKKLRYSNRHIQALSTPRQNVPYPMDANTASSPTTHNNVLHSRTQDEHRALNSLESALEQHFQALKREYEAKRGKAWTPLRPWTGEHSMCESESEWTEDDDDISMSRTAESQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8H6</accession>
    <name>R0I8H6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_35520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030699.1">
        <property type="nucleotide sequence ID" value="XM_008032508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8H6"/>
    <dbReference type="STRING" id="671987.R0I8H6"/>
    <dbReference type="GeneID" id="19404026"/>
    <dbReference type="eggNOG" id="ENOG502QR5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_4_2_1"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000028">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein (AFU_orthologue AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF38">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="217"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="607" mass="66809" checksum="4D348A1CC3818730" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8I1</accession>
    <name>R0I8I1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_157599</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="153" mass="17231" checksum="982D8253688AD782" modified="2013-06-26" version="1">MKTPSAAVIAILLSPFLAAAVAIPESSDIADIEVRSADVAQVDNVEKRADCWIRANWYNNWPSGGFRRYGVRLDAGPDSRRRDLLNIFCAILQGNNKQNINNKACYAEPDGTFKADITTFEGSHGHDLYLDFFQQNFNDWRGRTNCDVDNRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IE74</accession>
    <name>R0IE74_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor ISY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_164828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029164.1">
        <property type="nucleotide sequence ID" value="XM_008030973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IE74"/>
    <dbReference type="STRING" id="671987.R0IE74"/>
    <dbReference type="GeneID" id="19399259"/>
    <dbReference type="eggNOG" id="KOG3068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043453_2_0_1"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA83451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29060" checksum="680C55F1462D3CAC" modified="2013-06-26" version="1">MARNSEKAHSMLFRFRAAQAAEAGIIDISRTRRPKLITSVTSIPVCEKWRGQVLKEISRKVTKIQDEALSDYQIRDLNDEINKLMREKHMWESQIRGLGGPNYMRGGRVLDEEGREVPGGGKGYRYFGRAKELPGVKELFERQSRPEDDMDKGREKRSELRQKVDAGYYGYNLDEEDGTLLAYEKAKEREAWDNFLLLGDDLSEKASKTQKEWIELPGDAGDGIRWRVPTLEEVNNELVERRRRKLLEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0IEP6</accession>
    <name>R0IEP6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="5">1.1.1.n12</ecNumber>
            <ecNumber evidence="6">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SETTUDRAFT_164201</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.n12" evidence="5"/>
    <dbReference type="EC" id="4.2.1.119" evidence="6"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028265.1">
        <property type="nucleotide sequence ID" value="XM_008030074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IEP6"/>
    <dbReference type="STRING" id="671987.R0IEP6"/>
    <dbReference type="GeneID" id="19399034"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_18_1_1"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
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    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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        <location>
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            <end position="493"/>
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        </source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    <sequence length="903" mass="97945" checksum="68A8B2CB673194D2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">SETTUDRAFT_84068</name>
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            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="183"/>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="183" mass="21730" checksum="C052BCC6B89209DE" modified="2013-06-26" version="1" fragment="single">IRNEMLSQQRQADWLFTKLNEVMIEECYRYRKNEQPQRDSLVDAKQWEQFVNTAQSKIRTSKQCLAPLVKTAQYWGMNKVQHYEWASMGLKYCDVLAAAASRNPIWEDARVKLNQLLLRRITEGRFLRKTSNPFYLVDLEHLIAWTGKTDFERKGRRAYTLKYETIAQSDLPVDYVLDRFGII</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>[2Fe-2S] cluster</name>
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    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84370.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="174" mass="19462" checksum="B66C5EA0AEB32CAD" modified="2013-06-26" version="1">MSFLVSPFSRPSRAHNAWFCAGPASSYPNLDDTVRVGERRSCGANFVPGCRVFHVPQDDSSNATEVAIDDWKDPELGGNSKDQVMVFQYRGKFVAVNHECPHSSYPLSNGVPFDIEDFGVVLSSGIQCPKHDWSFDLHTGRSDRGSYKLQVWEVQQQAGAEGNEIWVRRKQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIG5</accession>
    <name>R0IIG5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="6 7">
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        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0IIM3"/>
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    <dbReference type="Proteomes" id="UP000016935">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="396" mass="43442" checksum="57BA792CE76F77DA" modified="2013-06-26" version="1">MRLSTAIVSAASIFSVAARVIDWPISNESELQPTIAFWDDDYAASGEWTTYTAKGGALMCALQGSDQTAGLQLKDTRSPPSAASHFNTDLKTELHTWYWRSVDPASFSCSFSDHWGFSKAMQALGLSGKPASQGGDNKCYRIEHWDPEKRDDNGNQIPALNQWYNVAGIEQQFRATKAHYEFAVNTAGGAIYGLFLLSPQASAKSLWHADKKDADKNALPQLRLFSDILWGFWVRDNPNVKNIRYFLMIGISNDVTNRLIASCLRDVGSELSAWPGTQFTMDTEQGHALLGSPNGAAFAYFLIQHKAQLGQKTITKVTVFRPENDDDIAFVDASLCFHVEDGVLAGDDGAGGDGDGDGRDGGDAPAIEVKNDYLIRETMVQPDKGNSITRVHEVYL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
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    <comment type="subcellular location">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">28A</strain>
        </source>
    </reference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Kosti I."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="329" mass="35678" checksum="78E05524EDDB311E" modified="2013-06-26" version="1">MATTTTQTPTPDLSKPPTTPVKTLTTVTPPGTPNATSTAAHQLVSEIRDIHDALCELTSLAPAPRINALLTRLVDLCVVPYSVDFTTRFFQISGVEVLCEKLRPICSAAEGELEKHWAQRMIDELDTNPHTPATTILQTFPYYTNYIDLSRLEASIINSFIDTPPTSIAFLGSGPLPLTSLCFLSRYPYATLHNVDRDATALALSSALCTKLGVAARMKFEREDVSLEVEGQDGGNVVGVGAKWTQAQVVFLAALVGMDTQTKLGILRDVVGKLRKGTLVVVRSAWGVRGVLYPILTLSEDLQALGLEVLAEVHPWTKVVNSVVVLRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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            <dbReference type="EMBL" id="EOA90956.1"/>
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    </evidence>
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    </evidence>
    <sequence length="390" mass="43765" checksum="114BC61E28C7595F" modified="2013-06-26" version="1">MYPRLPEGQDDAIRFDEGLAQAADGIAAFTRGLVDEVAKCISLSDPESLTEGEIAAMKASIDDLDSKQRSIFVSAGLNNLTSSLRHWTDHASILSNNIEIEHGPTPWSQKAKEVEAARKKDDEAVRQLQALTAEHRATVLKIHEREQIIATKELEIEHLSAKIRDAASKTEGVEALQEELAQRHEQIMELEEQNRAQAMDLEALKERLANVDESRRNDPELTTENTTAPIEQPQQAADPRSVPGGLKTFIDALQNENHWLRERQHKEAFDRNFREIFSTMDHSRHAAQMPSMSRLDALELAWLTDDDSEGVEASSRTSSPIPGDSNLAYHIPHAHAYGRPKMSALELTHISLGWEERAHSHKLALEQAEEELMLMSMIQEDDDDLSFIAP</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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    <dbReference type="AlphaFoldDB" id="R0J3M7"/>
    <dbReference type="STRING" id="671987.R0J3M7"/>
    <dbReference type="GeneID" id="19403395"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="426718at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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            <end position="17"/>
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            <end position="301"/>
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            <end position="232"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32138" checksum="1A424034C760FC6F" modified="2013-06-26" version="1">MLRIGAILLGAVYSVTAMPVELDTRAVSADVLSQLQFFSQYSAAAYCLDNNNSPNTKVVCPQGNCPLVQAANTNTLTEFENSLLTDVTGFVATDTTNKLIVVSFRGSRSIRNWITNVQFPVTPTTICSTCSGSLGFWNSWGEARQKVLAAVALGKSQFPDFRVVATGHSLGGALAGLAAGELRARGTPVDLYTYGAPKIGLEGLATYLTQTNNGSTYRVTHKADPVPKLPPTTLGYRHYSPEYYITNGNGVQPGTGDIQVLNGILNLNGNEGDLGFDIPAHLWYFGNISSCEGAPGIEFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0J468</accession>
    <name>R0J468_EXST2</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_162336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908481">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J468"/>
    <dbReference type="GeneID" id="19398363"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd17330">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
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    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="337"/>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="453"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="478"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="522"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="560" mass="61352" checksum="F5D6CD58DB928867" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0J590</accession>
    <name>R0J590_EXST2</name>
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        <recommendedName>
            <fullName evidence="15">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_153061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021013.1">
        <property type="nucleotide sequence ID" value="XM_008022822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J590"/>
    <dbReference type="STRING" id="671987.R0J590"/>
    <dbReference type="GeneID" id="19397252"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Glycerol uptake facilitator protein"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
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    </dbReference>
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    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA92065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43180" checksum="87D59E770806BBA5" modified="2013-06-26" version="1">MTAQGPMVPGPPMTHDWADNHSSSHLDSITSGNSAIPLTQSRTQQSTGSTDSKLSTQRTSSSAQRKRSVLGLHPQAPIDEGHEEAPQSGLVWSRIRTVMREPFAEFWGTAVMVMFGNGSVAQVLLSAGQSAAPGGNGFGQYQSINWGWGLGVMLGLYVAGDFGAYLNPAITFTNCIYRQLPWRRLPVYFAAQMLGGFVGSGIVYANYISAIDWFEGGKMRTVPPAEKATAAIFCTYPQPFLTKTSQFFSEFIASTLLMFVVFALKDPSNNGVPKSDKWFPLCLFFLIFGLGSCFGWETGYATNIARDFSPRLMSYAVGYSHEVWSAGGYYFWIPMIAPFLGCAFGGFLYDVFIYTGPSPVNSPWLGLKQLMPENAMWTRREHLRREKQEGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0J5L3</accession>
    <name>R0J5L3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_178459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022896.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S2F8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079969_0_0_1"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA92190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27647" checksum="B533AF7E6621B087" modified="2013-06-26" version="1">MASLPGFTTNFAAGYPTFQTPAGTFAHGSSSSGESPSVPNPPAEPHFDIFDWHPAYQSCQRYFLDHAQHDNGVQAVCALINICLPFQWSPNPLINASAPLPHASAPAAYNMPWPRQGPMTTARGQPPPAWVSLVPFIRRLVVTGMDSSGIMHGFFGEDWRKGVGPMHECERRNYLFTAKSVGWAKVKCQYDMSPHESVPFLKPLQEVQLAEIEGAEKTWSQWLAMEDWMVGPRAPDAQDEQLDARRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0J5Y8</accession>
    <name>R0J5Y8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_134561</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021166.1">
        <property type="nucleotide sequence ID" value="XM_008022975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J5Y8"/>
    <dbReference type="STRING" id="671987.R0J5Y8"/>
    <dbReference type="GeneID" id="19396262"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_8_1"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000692">
        <property type="entry name" value="Serine/threonine protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA92325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="567" mass="62249" checksum="9169DDEA96BAA001" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0J666</accession>
    <name>R0J666_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_114456</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021079.1">
        <property type="nucleotide sequence ID" value="XM_008022888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J666"/>
    <dbReference type="STRING" id="671987.R0J666"/>
    <dbReference type="GeneID" id="19395626"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="196"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA92176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="3853825at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
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            <end position="98"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81268.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="178" mass="20316" checksum="0AEBD8937B9670E0" modified="2013-06-26" version="1">MDGIEAMGARRAMSLMFTVPERFIGFAHMDQKTFFDLSDWILANVASQITPQISVEESLFVFLDIVAQGNSFSHVAYGWDHDLELTHGIFLNVLNALTVLRASREIADTCPPFTQARKRWEVTRRWNQKRSRPNPGGIVRIGYDEMSRDGLEVDQECLKEALMALNNFIHENADHDES</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="1093" mass="118052" checksum="FB10B704DC50C69A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0JMC7</accession>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
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    <dbReference type="AlphaFoldDB" id="R0JMC7"/>
    <dbReference type="STRING" id="671987.R0JMC7"/>
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    <dbReference type="eggNOG" id="ENOG502SK0G">
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    <dbReference type="HOGENOM" id="CLU_046574_1_0_1"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="374"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA82398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="393" mass="44304" checksum="A885D323C12F3760" modified="2013-06-26" version="1">MSPGVLSAEPGFTVTPMSKTEKEKPNFGAVIEDLDLESINADEKALAETIWTHKLVVVKGQKNLSPIKQWELVTRFDPEAPQVHSHGDVKTFHKQGGLLTKGRDVIGIPGAENVRLIGKGHQGEDHYGLKDVTVQKGVLHAWHDQPPTDEEYQAGHTRFQRWHIDAPLYARDPAWFTTLRCIRRPTAPTLTIHWDDGSGQTMETEPGLTAFMSSVQTYDMMTDEEKKIADHSWVEYAPHPYQWMGDCKGQPNGLGVVSQCQEKRLEDLGDYDQKDIKRYPMTWVNPVTGERAFMVHGICVRRAFFRSSAHEEPRVVDDVAAIRAWLKPIQERVLKPEFILLPRVDEGDVIMWANYQLFHTAVDYPDHWGVRTMHQANIGASAGPVGPVPIPVA</sequence>
</entry>
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    <accession>R0JRH7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_155087</name>
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    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3051910_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="54" mass="6096" checksum="BC2AC248F7872BB7" modified="2013-06-26" version="1">MPSRCQQSRRRSLSRPVGGYVDSSTLAYRIQYIFEPPGLGASWGHHPRAEISVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JT57</accession>
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            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
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        <name evidence="8" type="ORF">SETTUDRAFT_119389</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028608.1">
        <property type="nucleotide sequence ID" value="XM_008030417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JT57"/>
    <dbReference type="STRING" id="671987.R0JT57"/>
    <dbReference type="GeneID" id="19395780"/>
    <dbReference type="eggNOG" id="KOG4600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062495_1_0_1"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="272" mass="29966" checksum="38B00B6C14323A67" modified="2013-06-26" version="1">MLLPRIFAPVRASIATSAAFIAPSTRVIDALRVANGSTAPAPVLSFVRHSAHQAQGRANGAKDGPGKRLGAKKSGGEYVIPGNIIFRQRGTSWFPGENCKFGRDHCIFATESGYVRYYRDPRKHPNRQYIGVALEKDHKLPYPPNAARRRRLNMLAVPITSSSKPSADAVVVAELQVGDATGSPSSIRETPRETANKGLRLTTGKGYAYRQANWEIGRAAERAGVKVKEFVPGDRWTAWRKRNIRIQANMERKRLKNAGKKASKPKARKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0JTL6</accession>
    <name>R0JTL6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_52555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031094.1">
        <property type="nucleotide sequence ID" value="XM_008032903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JW41"/>
    <dbReference type="STRING" id="671987.R0JW41"/>
    <dbReference type="GeneID" id="19406376"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087356_0_2_1"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA81704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="167" mass="19591" checksum="F42E7558611D22B2" modified="2013-06-26" version="1">MSLGPPNSAPLPSSFDENADFYNENTMDKIWRRLREEPLVPLGCGLTVWAIVGATRSMRKGDHKMTNLYFRRRLYAQAFTIAVLVAGNMYWQKDRVKRKEYEAKVADKERMDKRDRWLRELEMRDEEDKAWKERMAKRARGAADEAKGVTDMVAEKTKELKDQTWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0JW73</accession>
    <name>R0JW73_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_174378</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031115.1">
        <property type="nucleotide sequence ID" value="XM_008032924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JW73"/>
    <dbReference type="STRING" id="671987.R0JW73"/>
    <dbReference type="GeneID" id="19401320"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
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                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EOA82254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="294" mass="34297" checksum="B1824BEC719E53F5" modified="2013-06-26" version="1">MVASHSITFNENRTKLMSLLGFSQEENFYEWRQSEYFLSAWDTFQNEFIPSYDLAEEIASYTTKDILEYIGNMPENYFTRFDSPDIIDGPFEWCIWTVSLLIRLNSDWPKGAPNLRYKVCDMKIQSIDQAKSNAIYDTDRKYRYDIMLEVVDHEVRFANDIEKDIARLTRALKIPCSTDVSKYPDVGLVEIFWENGFDFVETEAERRCIINGICGNTMSTFVDRVREIFRLKERKQTIVALGMVSEWGTVDYHSFSLLRTQRLSIKANGQRSFRLLTKQIPEVACVGGQFSVND</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="23">28A</strain>
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        <text evidence="18">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
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    <comment type="similarity">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <source>
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    <sequence length="621" mass="67040" checksum="959E3DD962B51413" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K091</accession>
    <name>R0K091_EXST2</name>
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        <recommendedName>
            <fullName evidence="9">SH3 domain signaling protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">SETTUDRAFT_164567</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
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    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53647" checksum="7B3F6F6BD841B28B" modified="2013-06-26" version="1">MQRMQRFTGRFLTRTPNEADVEAMLKDFNDSKVMLEKLEASAKQWRDAWTNILNHQLSSVECLYTIFKPLGGEGGSATHVHAETPAAVLERVHGLHEAFAELKTDMMEEVKDIDRKLVVPAKLARDALKPMEKAIKKREDAKIDYERYKSRCESLQNKKTRSERENSALAKHEADLERSTHAYQLADENLRERLPRLNAATFSILPHLLSNQIVLQNNLIGNLYTVLQQYSQEQGYPDPPPEPEEVIPIWDSSFTPLRTEMETSLGLLKTGKAVHQPMRLPDKGDTVTGLGIRNKVLPGRRASSNDSVPTISSSRPARPSQTLSPTSEGGPPPISLANKPSYSSLNASKPKISSSPHLSAGQDMYGRRLSSTSQASSYSNGTNGDGYFGKPAASSNGSTPSGYPTSPNPAAGKKKPPPPPPPKKIGSFQAEYVTAMYDFDSLTPGDLSFREGDRIRVIKKTQSSQDWWEGEIHGQKGSFPANYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0J9</accession>
    <name>R0K0J9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_33523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028798.1">
        <property type="nucleotide sequence ID" value="XM_008030607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0J9"/>
    <dbReference type="STRING" id="671987.R0K0J9"/>
    <dbReference type="GeneID" id="19403788"/>
    <dbReference type="HOGENOM" id="CLU_1184921_0_0_1"/>
    <dbReference type="OrthoDB" id="3695594at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="219" mass="25107" checksum="B1114D442CCBF04F" modified="2013-06-26" version="1">MDRIYAGAYVTVVACVGEDADYGLPGVSRRREVQPCAMLPEFNLAASLPPLSTAMRNSKRMTRGWTYQEAMLSRRCLFFTNKQVYFVCPNMGCCESLLVHSSARQSYHDDPWQVHTSLSTKMFEEDSYAQLSRNLWKHHTDPSVLHFGELMNHFLQYIPRQLTHQEDILDAFHGLLNRSSFYSYYGVVIALAGNPIAPGEFEHGFIRGLFWTTVPDLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0K132</accession>
    <name>R0K132_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_173832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030423.1">
        <property type="nucleotide sequence ID" value="XM_008032232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K132"/>
    <dbReference type="STRING" id="671987.R0K132"/>
    <dbReference type="GeneID" id="19401275"/>
    <dbReference type="eggNOG" id="ENOG502S8V0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132206_0_0_1"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14811" checksum="AE394EBE757E11E0" modified="2013-06-26" version="1">MAIFGTALNGVGALLLTHAVYSAHEHTATFATSPLPLDITLELLTSILLLSLGIVVSFAPLKPIYCAQWAGQISREGRHSEGQYTNEGEEVLSEGDPYAFLGLDGGIGGKSEGRKGFWDVKGKRKEFETWMREGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K255</accession>
    <name>R0K255_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_138258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028211.1">
        <property type="nucleotide sequence ID" value="XM_008030020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K255"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HET"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA83694.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="531" mass="60400" checksum="9132F734F8901B4F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2N0</accession>
    <name>R0K2N0_EXST2</name>
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        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_22603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008031165.1"/>
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    <dbReference type="STRING" id="671987.R0K2N0"/>
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    </dbReference>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="HET"/>
    </dbReference>
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        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="342"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
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    <feature type="repeat" description="WD" evidence="6">
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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    </feature>
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
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            <end position="1139"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1251"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA82622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2Q5</accession>
    <name>R0K2Q5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_164277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2Q5"/>
    <dbReference type="GeneID" id="19399073"/>
    <dbReference type="eggNOG" id="ENOG502T6G4">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_197719_0_0_1"/>
    <dbReference type="OrthoDB" id="3889179at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="78" mass="8888" checksum="95B3CF1573FE9B2D" modified="2013-06-26" version="1">MPEAERTSNGDYEEIDYCTFEAVDYDRLMSWKAGDGRISVGVREMTQQNARIDTIDALLPRGRSVIVNKMSFKLVRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0K352</accession>
    <name>R0K352_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Short chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_177123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="213" mass="24945" checksum="F5A711C78356DBE2" modified="2013-06-26" version="1">MSNTLPDFPFFVSTGDGWRHETARYVRDRPQRGWYQDGRKLRDVKASKAFIWPKDGKNGSSWGRIKDVLRNNGPDIYVAFGARQTDCVSNRPPRSQWAGYPHLDDRGMTFSFNSQKFAPWTKSSMLGGREYGLSYDFRTRKYVKPNRWTWTDAIWQQEPYKNRKANSYPEAVRMLDGQWFQDTQYLPQFLAGHIDNEFGVGVPFHHLPFSPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3L3</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
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    <dbReference type="eggNOG" id="ENOG502T52U">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="91" mass="11109" checksum="2AB817D1F91F4435" modified="2013-06-26" version="1">MSELPPLRKDPYALAYRYKEYMTKYPRRRKESRNPYYDKLLANLPDPAEDAMDNRSRAIRYAKKHYECYYEIRDIRRIVAWLPPVEEESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3S4</accession>
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                <person name="Martin J."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Bushley K.E."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502RI25">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="432970at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
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        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT/MYND zinc finger-like"/>
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    </dbReference>
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        <property type="entry name" value="ZF_MYND_1"/>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="4152607at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="179" mass="20275" checksum="BF21E725D6F06D85" modified="2013-06-26" version="1">MTQDIEHLDATVFMPHGMLEGLSDQFDCIPHYLFRTSSPRSGGTTNETHVASVAAINHFDQSDILARDWDEAVVMLQQHLLWEPYAEDNLVSWTSSFIFVVQHAIRREETDKPTSASNSIYISVLDTRKVPRGTFLPARALLKAYDLPDEGKLKHDFYYGEYISQGSLYSDAISTTTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0K672</accession>
    <name>R0K672_EXST2</name>
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        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_138458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="protein sequence ID" value="EOA83822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028305.1">
        <property type="nucleotide sequence ID" value="XM_008030114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K672"/>
    <dbReference type="GeneID" id="19396458"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF20">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA83822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="565" mass="61499" checksum="269C893489AD5CA1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6N5</accession>
    <name>R0K6N5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_163894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029463.1"/>
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    <dbReference type="STRING" id="671987.R0K6N5"/>
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    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_1"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
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        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="13"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="510" mass="57847" checksum="2AF2DF6B271A99DC" modified="2013-06-26" version="1">MTSEEQKATPENNTLFQGFEWNVPDDHKHWKRLAEQIPKLKAIGIDNIWLPPGCKAANPKGVGYDIYDLYDLGEFDQKGATGTKWGTKEELVELTKVAKEHSIGLYWDAVLNHKAGADRTEKCRVVEVDANDRTKEVSDAYEIEGWLGFDFPGRGEQYSQMKYHWEHFSGTDYNQANEKKAIYKILGDNKGWSKHVDDEQGNADYMMFADIDYSHPEVQEDVKKWGVWITKELGLKGFRLDAVQHFSSRFTSEWIKNLREQCGDVFIVGEFWSGDVKEMSDWLDEMNREFALYDSPLLNKFGSLSTTESADLRTVFDDTLVQLRPVDAVTVVTNHDTQPGQVMETKIEEFFKPLAYALILLRQEGYPCPFYGDLYGLSEPHETPASCGGKLGDLILARKLFAYGAQEDYFNEANCIGFVRRGTWDKVAGLACVMSNAGPGQIRMAVGEMHAGEKWSDVLGWEQGEVEIDREGYGLFKCPGTSVAVWVRSDAEGRERFPTKFDADVYHKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0K882</accession>
    <name>R0K882_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_152128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908659">
        <property type="protein sequence ID" value="EOA85669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026744.1">
        <property type="nucleotide sequence ID" value="XM_008028553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K882"/>
    <dbReference type="STRING" id="671987.R0K882"/>
    <dbReference type="GeneID" id="19397164"/>
    <dbReference type="eggNOG" id="KOG4835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064339_1_0_1"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="370" mass="40694" checksum="AB0E2A62F76C5DBD" modified="2013-06-26" version="1" fragment="single">MDPQIDLPELVEDLEVNIDELSTALEPLLATPLHTTASSLPLLDKAKLYCLSAYAIESLLFASLTASGVNATEHAIFKEIARLRQYNTKIKVIEDRGIKGSAEGRARLDVAAAGRFIKHGLAGNDKYDLERQERMARERARAHLKAQQINKKFDDEGKEVKGEGVTPKKRGADEVDDQDESDEELEGLEESEPAIKKARVNAAEPMDIDSEAASSSHADSKKQKKKGKAKGKRGQKKRKQSTEDSDVEAGDDVDKDESLAEPQAEMDSTRQAKQRGRLPKKDKKAAKQEDGSTDVDATPSQAEARVTRKRNKRLSNQNMDDDEGEEEGDEEKESMMPTPDRAPKTRSETFTALLDGSIGDKHKKSKAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8E1</accession>
    <name>R0K8E1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_91360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZPS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027172.1">
        <property type="nucleotide sequence ID" value="XM_008028981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8E1"/>
    <dbReference type="STRING" id="671987.R0K8E1"/>
    <dbReference type="GeneID" id="19405898"/>
    <dbReference type="eggNOG" id="ENOG502RTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048223_0_0_1"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11307">
        <property type="entry name" value="M35_Asp_f2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000043">
        <property type="entry name" value="Major allergen Asp F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354002" description="Putative peptidase domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="306" mass="32158" checksum="C233D1A6CFB102E5" modified="2013-06-26" version="1">MAARASALLLLGASAIMAGPIAVRDTTVATTANVQAVVGTTTWNVGAVDSFPIHGSCNVTQRVMLERGFNEAIALARHARDHILRWGHDSEIYTKYFGKAPTGEPIGWYTKIADGDKAGILFRCDDIDGNCSQDGWAGHWRGSNATSETVICDLSYQIRKPLEAMCMLGYNVANGATNYFWGSDLIHRLLHVPAVGEGAVEHYAESKDGKYPAVLSLAKNNATFAARDSDAIQYFALEAYAYDIAVPGVGCPGRYTPPKASPTGTATPSPTVSPSATPASASAAAAAATSSAAAPAEACQPHGDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K908</accession>
    <name>R0K908_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_90044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027302.1">
        <property type="nucleotide sequence ID" value="XM_008029111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K908"/>
    <dbReference type="GeneID" id="19405811"/>
    <dbReference type="eggNOG" id="ENOG502SX1S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760727_0_0_1"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="331" mass="33952" checksum="487AF4AC550B774A" modified="2013-06-26" version="1">MSAGPPPGHAWHPNVGNNPNINREPPPPPLDGAAPFAPAPAPAPAQVVVEHQHHNPVYAPPLPIGIAPPLGIPIGAFPPIFMDPFVGFAPHPLPGAAPLAPIRSGNFLPNAQYGIGFGLHAAGVPIPPPPPGSTLAPFAAAAPLWTMGGGGLAFGNVPVAGVPPVVPMVPMGGGIMGGATQHARAAPLFHDANNGHAAQPAQTDVSQIAGGIPAGVMLVESAEHTIFMRITGNICPWLSPGAQLPVEQLAAASTTGLNRLIQICNEGVPVEELEGTAVTECIELGNGLWEKGQTFRYNDAVSKVLTMKDAGWDNTRNRAGGNSLHLWGHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBS1</accession>
    <name>R0KBS1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">SETTUDRAFT_169661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="function">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="110" mass="12313" checksum="0800C50757878233" modified="2013-06-26" version="1">MPAPAEQAPLAPPTPLNVKQLNRIQKRRIAREKLQAHLALKRENAKLYGESPPYSSRPQQIQGCMRRPRGPNGRFLTPEECILIQTMNTLALQNSKPPSPPPLFTAKAKL</sequence>
</entry>
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    <accession>R0KED7</accession>
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            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <strain evidence="4">28A</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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    </reference>
    <dbReference type="EMBL" id="KB908592">
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        <property type="nucleotide sequence ID" value="XM_008027009.1"/>
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    <dbReference type="AlphaFoldDB" id="R0KED7"/>
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    <dbReference type="eggNOG" id="ENOG502SN6V">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="HET"/>
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    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
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            <end position="107"/>
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            <end position="348"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Pfam" id="PF06985"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEH4</accession>
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            <fullName evidence="12">Mitochondrial inner membrane protease subunit</fullName>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="12"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008026418.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0KEH4"/>
    <dbReference type="GeneID" id="19400697"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9996127at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMP2"/>
    </dbReference>
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        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA87719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="208" mass="23879" checksum="AFD9C9C919D71293" modified="2013-06-26" version="1">MCAMLFVRDHFVEFQHVRGSSMAPTLSPDAHETGREDYVIVRSYLWRGKRASEEHDAAWDIQRGDVVTFWKPHKPSEMGIKRVVAIEGDTVYPTRGYALDPASYQSRMQGFPDGLADRDPDSIVPEPEVGKVVVPYGHVWIEGDNWRRSLDSNDFGPISKGLIQGKAVKVWRNWFSLMDVADERKRRENDMRSRIVEGRSEIPQAYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KET4</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_53802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024568.1">
        <property type="nucleotide sequence ID" value="XM_008026377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KET4"/>
    <dbReference type="GeneID" id="19405196"/>
    <dbReference type="HOGENOM" id="CLU_2801138_0_0_1"/>
    <dbReference type="OrthoDB" id="10381720at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="68" mass="7818" checksum="68E837AFE1A6F1E0" modified="2013-06-26" version="1" fragment="single">GHMEDVEGMDSEKCDLLRVNYRRDTHEFAKGDSHYQLRRELCDEGVMDHVTLDLALNKSFDGGGRGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KF45</accession>
    <name>R0KF45_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_162915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025340.1">
        <property type="nucleotide sequence ID" value="XM_008027149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KF45"/>
    <dbReference type="STRING" id="671987.R0KF45"/>
    <dbReference type="GeneID" id="19398586"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_4_2_1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OSBP"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
    </feature>
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        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="523"/>
        </location>
    </feature>
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        <location>
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            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA86722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="64138" checksum="8BCBF9C274E02304" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KF57</accession>
    <name>R0KF57_EXST2</name>
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        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_41289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KF57"/>
    <dbReference type="STRING" id="671987.R0KF57"/>
    <dbReference type="GeneID" id="19404686"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="311"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="431" mass="47406" checksum="4BE93B89FB103391" modified="2013-06-26" version="1">MAKETSRLDVAIVGGGISGLSLAIALLKKCPHMHVTVYESASAFGEIGAGVGFEPVMVRTMKLIDPRIAAAFEKCTKGNTVTEPPRWFTVRFGDERKKDVQLGEEVFVMPARRGPRGGVHRAHFLDELVKLVPDGIARFGKRLQNITEAEDGSGDAVLHFADGSTAQHNAVLGCDGIKSRTRSIILGDSETSTAVFSGKYAYRGLLPMTKAVEILGEVIPKTPQMYMGYHGHVLTFPIANGTLLNVVAFASRQTWDNPEWVVQTSHEDMLDDYKHWTPTVRDMIGNLQKPDIWALFDHPPAPTYYSAKPLVCLVGDAAHASTPHQGAGAGMGVEDVYILGELLSRCDAKSDITKAFQAYDAVRRPRSQKLVKTSREAGMLWDLEGEGVDDHLEAHKQNSLSRMDWIWDYNILDDLARAMEIMETGTNVETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KH66</accession>
    <name>R0KH66_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_162671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021102.1">
        <property type="nucleotide sequence ID" value="XM_008022911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KH66"/>
    <dbReference type="GeneID" id="19398480"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_20_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022289.1">
        <property type="nucleotide sequence ID" value="XM_008024098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMW8"/>
    <dbReference type="STRING" id="671987.R0KMW8"/>
    <dbReference type="GeneID" id="19400123"/>
    <dbReference type="eggNOG" id="KOG3121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088622_0_0_1"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="213" mass="22065" checksum="A6224E0A943D077F" modified="2013-06-26" version="1">MSRPAARKAAPKGEYIETDSGNKVSRRSAITGTANITLGGRTVIMADVQLRGDLHPTRSAPSQSGKDVTPTSISIGRCTVISQGSVIKPPSRISRGQVHYYPMKIGDNVFVGQNSTIQAISISSHVHIGQHCTIGPFAIIKENVKILPHTVVPANMVIASGSVIGGRPARVVGDVGEGWGVSGGGGGGLGVGGGGEEKWVEGGDLRELVRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNC6</accession>
    <name>R0KNC6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_126756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022376.1">
        <property type="nucleotide sequence ID" value="XM_008024185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNC6"/>
    <dbReference type="STRING" id="671987.R0KNC6"/>
    <dbReference type="GeneID" id="19395993"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035836_0_0_1"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1180:FF:000001">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="455" mass="51833" checksum="63553B5279D3A575" modified="2013-06-26" version="1">MAATPSIRQFTTCLRCVRQLPSANGTRRLLSTSAVAREELHTPSANATPPPPPSNPPEGAAQKAPAPAVPEYMQKWGTLDPQMVENKKQERRLLRREHALPVGSRRRRAVLRRSALQKTPEIPFEQLPYQCFQEARKFLLEDRQEKIKEIETQQLRIKNLMAQDPSVSGGPAAKEHRLRSMRKHLNELIILADINDPVVKKRFEDGQGDMNKPIYRYLADKKWRQYKRLVLEQRVTQLAIIPDLLPSLDLVADIDLGFGRKTIPPGEFVDSAISEKLPRLNVQTFTPGEKLVTVVVVDADVPVPETDSFTYRCHLIASNITISPNNTSIPLQRIAQDDQKTEDPSAKKIALPWIAPWAHKGAPYHRLGIFVLEQNAGQQLDVTKFNTVKRMGFNLRSFVDTNKLKPITATLFRTKWDESMAGVMERAGLKSQIDVEFKRKKVEPLPYKRRTERMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNH0</accession>
    <name>R0KNH0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_105135</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023232.1">
        <property type="nucleotide sequence ID" value="XM_008025041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNH0"/>
    <dbReference type="STRING" id="671987.R0KNH0"/>
    <dbReference type="GeneID" id="19395084"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_127_1_1"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="136"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA89462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="421" mass="47744" checksum="E1E564CB6E44EAE1" modified="2013-06-26" version="1">MTSRLSSMMGIKSSANGDKNGDVKATTNGATANGRSPPARQTSVNKREGPSAPYKRFWTNEDGSHEHHLKVAKRQEKLSDMFQNLMLGKKKGEAPEDQPLSLMSNWVDVMRNEKEKLAEQKNAVNALPQTLVQKYGKCQEVVGRGAFGIVRVAHKQDPKDSKREQLYAVKEFKQRPGESAKRYQKRLTSEFCISSSMQHPNVITTLDLLQDEKGTYCEVMEYCSGGDLYTLVLAAGQLEVAEADCFFKQLMRGVEYMHEMGVAHRDLKPENLLLTTHGSIKITDFGNGECFRMAWEKEAHMTAGLCGSAPYIAPEEYVDKEFDPRAVDVWACGIIYMAMRTGRHLWRVAQKGEDEFFDRYLEDRKEEEGYRPIEVLRRRQCRNVIYSILDPIPARRLTAHQVLASEWVSEAKVCRAGNEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPN0</accession>
    <name>R0KPN0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_26138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022417.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPN0"/>
    <dbReference type="STRING" id="671987.R0KPN0"/>
    <dbReference type="GeneID" id="19402982"/>
    <dbReference type="eggNOG" id="ENOG502R9DT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068279_3_2_1"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18738" checksum="8412E656527D60FB" modified="2013-06-26" version="1">MTTKKKPDHGRIPVEAAVNMQDVVTVNVGSKPEKYIVHSGIISNTSKFFNNCLKPAWSASHATGDIDLTDEDPVIFGIYLNWVYCKTLPTIITGDGTDGPGEYDTLSECYVMGERLFDIDFKNDVMDAFVEAMHRHPFDCHRSSRTGPVDIIYGGTPEGSPARRLIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQ15</accession>
    <name>R0KQ15_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_158567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021751.1">
        <property type="nucleotide sequence ID" value="XM_008023560.1"/>
    </dbReference>
    <dbReference type="SMR" id="R0KQ15"/>
    <dbReference type="STRING" id="671987.R0KQ15"/>
    <dbReference type="GeneID" id="19397836"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_3_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="359"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1575"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1192"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1347"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1523"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA91104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2358" mass="258952" checksum="854D6DAE6327C2D8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQJ0</accession>
    <name>R0KQJ0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_162047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020569.1">
        <property type="nucleotide sequence ID" value="XM_008022378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQJ0"/>
    <dbReference type="GeneID" id="19398259"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="4160219at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="440" mass="46264" checksum="BA33D0EDCFD8DF11" modified="2013-06-26" version="1">MAISIGSIVTCTSMSFEHFILGRVITGAGGGGIFIVASIMAIQMTSPKRRGLYMGLANTAMTVGVSLGAVIAGALEPRIGWKPLFGIQVPLSFIAGLCLLLSIPASHNSNSIKYTNLSIRDKLARIDYTGALLLTATIVLFLLGLSGPKVLPTPIILSAVALPLFVLNEAYVASDPVIPVSVLRSRGTLLTCLATTGFMMSRWSILFYTPVYSLAIRGWAPAVAGSILIPTNAGFACGGLLAGVFHIKRTGSFYLHTLISMALFPITMVVLAFISTPTSPWTLYVVVVFSNGLATGAAMNYALVHLLHVTLPEVHPIVISLLATFRGFSGSFGSAIGGGYFVRVLHKALDEGFAQSGLKNRGELTRRLLGSPALVSKLDGKDKAVAVGAYAHAIKALFICAVGLSLLAVFVQAGTGWKAPEQSEQREEEAEVEGNVPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRA9</accession>
    <name>R0KRA9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosylmethionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_162240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020711.1">
        <property type="nucleotide sequence ID" value="XM_008022520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KRA9"/>
    <dbReference type="STRING" id="671987.R0KRA9"/>
    <dbReference type="GeneID" id="19398316"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030437_1_0_1"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="42669" checksum="7477E2B45807E674" modified="2013-06-26" version="1">MSASLTGAGLPPSTTLPSLRSPQSASEARLTSALSNLRALYCPVRLPTLISSPTSRRDHRSITSPPRPVDSGYASHDDDDDAAAAADAATLQDVTAALRADPFERSFAIQWLNSLIARSDDLHMHHDARERLVDDAAVILSSLFESTTSHDEEALTRNFAFAMPSGEAIKVTLNDAPLSTTDHTAVGLQSWGASIVLSSLMCADPTRFALDSPSLAPHPHITELGAGTGLVSLVLAKLLPAMHVATATILATDYHPAVLQNCTANINTNFPPTCHDAPPVKTAILDWAQPPPHLKATSHLLIASDVVYAPEHAAWLRDCAAHLLTTTGTFWLMVTVRKTGKFEAIPDTVESAFAPKLCPRNDSGMTFQILEKDFVDKRRGIGRGDETGYNLYRIGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KS76</accession>
    <name>R0KS76_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_101380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021423.1">
        <property type="nucleotide sequence ID" value="XM_008023232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KS76"/>
    <dbReference type="STRING" id="671987.R0KS76"/>
    <dbReference type="GeneID" id="19394851"/>
    <dbReference type="eggNOG" id="ENOG502T0Y7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725920_0_0_1"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344509" evidence="1">
        <location>
            <begin position="25"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="383" mass="41476" checksum="89C2532E24A54511" modified="2013-06-26" version="1">MLALSSLASLPPLLFSALIAHAHASHDGVIGDNKRPSRPTYATALTGGEGCDLTEIDDVRDGFSEMTSLFAAATPFDLTSQPARELFGPSIAANYSDMIAKSLQRAANYGVVNGEAGAVNANIHIRCDDPMDLCDKGNRREGKHAAYNIGNEPHINFCPDYFAMDSLQTRVDVKSNDQIQKDRLMEYYNRASLWARMVMHFSDIGTAIVQRPRPAPPNSTSEWLIDAYEGPMNTSVLAGVLNEQGDGPIDRQTLKYAYGATRAKLLASLSTQMPYDAANNAENYALYALSKYIIKTKGFYPAVPIMDFPNEASVLTNENLQDGERCKYAFFDMLDVVARPADMESKGAPLPSAASSVHAPLSSAMMGVAGVVMMYAFVASSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSA7</accession>
    <name>R0KSA7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_166608</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021444.1">
        <property type="nucleotide sequence ID" value="XM_008023253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSA7"/>
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    <dbReference type="GeneID" id="19399869"/>
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        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
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        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
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    </dbReference>
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    </evidence>
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        <source>
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</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">SETTUDRAFT_86238</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </feature>
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        <location>
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    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="532" mass="58206" checksum="C1A68E166E7E9727" modified="2013-06-26" version="1"> </sequence>
</entry>
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    </protein>
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        <name evidence="6" type="ORF">SETTUDRAFT_44859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Pleosporales</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
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    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="METTL2/6/8-like"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="PANTHER" id="PTHR22809">
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    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
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    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="222"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA81040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="492" mass="55748" checksum="9037D78686B864FF" modified="2013-06-26" version="1">MAAETDAATAPAQHVASGAHSEQSSDPRFQTDNSVSRKPQPKQQLSKAMEHMRFAVTADPIPHSSTPKSPPQQPARDASSPSTEQQQIPENDAYGVPASFAPVRAPQSRSHDPSNNQKRSDPFAFGSRYLEEGDDIFEFNAWDHVTVDANYLAFSEEQYSKQRSEPVSEFDRKRFNEQPEKWWNQFYKNNKTNFFKNRKWLAQEFPILEELGAEDGPEATLLEVGAGAGNSAFPILQRSRNKRLKIHACDFSKKAVELIRNHELYNPELIQADVWDVAASPDSDNGGLPPGLSEGSVDVVLMIFIFSALSPKQWDQAVRNIWRVLKPGGQVLFRDYGRGDLAQVRFKKGRYMEENFYVRGDGTRVYFFEQEELQQIWAGKESQLRDTQTGNVADTTTITTTTTTEDPHALADKIQNIDLRHPDVQSPAQANADAADLLTPRPAFQVAHIGVDRRMLVNRQRRLKMYRCWLQAVFRKAGEESCVPTRYKMEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6B5</accession>
    <name>R0I6B5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_158064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031646.1">
        <property type="nucleotide sequence ID" value="XM_008033455.1"/>
    </dbReference>
    <dbReference type="SMR" id="R0I6B5"/>
    <dbReference type="STRING" id="671987.R0I6B5"/>
    <dbReference type="GeneID" id="19397784"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_37_5_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="6"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="945"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2406"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="945"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1096"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2499"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2522"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="977"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA81125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="2907" mass="319129" checksum="5EEFD2640CA5D561" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6S4</accession>
    <name>R0I6S4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_99381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
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                <person name="Han J."/>
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                <person name="Bushley K.E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="115" mass="12778" checksum="F2BF9EA2AD888CF1" modified="2013-06-26" version="1">MSVFVAVPGPLLPYARYQGASILDTRQPRAHCSSATPIGTALGWDICASKLQPRSETAMEPIFCRVGRIHDRQMHVGVLYGARTSLIESGVSTQARRNERWVQTRLLFSESEDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IFJ3</accession>
    <name>R0IFJ3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_138482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028316.1">
        <property type="nucleotide sequence ID" value="XM_008030125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IFJ3"/>
    <dbReference type="STRING" id="671987.R0IFJ3"/>
    <dbReference type="GeneID" id="19396460"/>
    <dbReference type="eggNOG" id="ENOG502QS7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_7_1_1"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA83836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="216" mass="22332" checksum="10E4293DE9A0487E" modified="2013-06-26" version="1">MAHHPPSGPARGLAATMGWGARPALLVVDVCKAYWSDGSPLDTSSNAAAAAVPAAIARLVAAARRGAAPLIWTRVEYSEPDMADAGLFACKAPLLDVFHRDDARGLGAWMPGLAPAPADVVVCKRYPSAFFATDLATRLRLASVDTLVICGVSTSGCVRATALDAMCLGFRPMVVGTACGDASPAVHDANLFDMNAKMADVIGEPDAVDRLSAGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IH92</accession>
    <name>R0IH92_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_119530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028668.1">
        <property type="nucleotide sequence ID" value="XM_008030477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IH92"/>
    <dbReference type="GeneID" id="19395786"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA84351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="543" mass="58839" checksum="F04307B3F20D3E71" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHU9</accession>
    <name>R0IHU9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_136808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="190"/>
        </location>
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            <end position="473"/>
        </location>
    </feature>
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            <end position="63"/>
        </location>
    </feature>
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            <dbReference type="EMBL" id="EOA85125.1"/>
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</entry>
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            <fullName evidence="4">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <strain evidence="10">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="565"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="422"/>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <sequence length="758" mass="83159" checksum="0EC4F494E1435A07" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0IKK4</accession>
    <name>R0IKK4_EXST2</name>
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            <fullName evidence="3">chitinase</fullName>
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    </protein>
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        <name evidence="13" type="ORF">SETTUDRAFT_152014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
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    <comment type="similarity">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Chitinase_insertion_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA85615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    <sequence length="431" mass="46789" checksum="562603DA1422E7F0" modified="2013-06-26" version="1">MRTINLLVGVTSLLQSSAIVQAFPIAQANSNSTMPAATSGYKNVAYFVNWAIYGRNYNPQDLPAEELTHVLYAFADVRDTGEVFLTDSWSDTDKHYANDSWNDVGNNVYGCVKQLFLQKKRNRNLKVLLSIGGWTYSSHFVVPASTPEGRAKFASSAVAILANVGFDGLDIDWEYPADATQANNMVLLLAAVRQALNDYSNAYANGQHLLLTVASPAGPTHYNTMKLAAMDQYLDFWNLMAYDYAGSWDSYAGQLANWAPSASNTNSTPFSTVKAITDYVAAGVPASKIVLGMPLYGRSFANTAGPGTPFQGVGQGTWETGVYDYKALPQAGAQIYTDMQITASWTYDSNSKLMISYDTPEIIARKSQLIIQNGLGGGMWWESSSDKKGSDSLISTYVNGVGGIGALEQSPNLLSYPQSKYDNLRAGLPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0IM48</accession>
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            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026358.1">
        <property type="nucleotide sequence ID" value="XM_008028167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IM48"/>
    <dbReference type="GeneID" id="19400909"/>
    <dbReference type="HOGENOM" id="CLU_126889_0_0_1"/>
    <dbReference type="OrthoDB" id="3796976at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="167" mass="18657" checksum="3F9F917DA5BDA7B9" modified="2013-06-26" version="1">MTVYRCSRCEEKNLRCFVDTATGRCASCISVKAKCSLFVSKEEWEKVQQEREQKELEVARAEEAAARLRRELLKVKSRERSFARRDLAILEFQDRAKEKAEGSSAPGTDLPSTGPSLPAQSTDLGWLQADSSSFDPLSLDFFLSYENPILASVDVSNSTHVLVTCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0IM62</accession>
    <name>R0IM62_EXST2</name>
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        <recommendedName>
            <fullName evidence="14">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">SETTUDRAFT_161582</name>
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    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_008028172.1"/>
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        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
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        <property type="entry name" value="ER"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
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        <property type="entry name" value="Ketoacyl_synth_C"/>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
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        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="53"/>
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            <begin position="985"/>
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    </feature>
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            <begin position="1"/>
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    </feature>
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        </location>
    </feature>
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            <begin position="1133"/>
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    </feature>
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        <location>
            <begin position="1"/>
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            <position position="1017"/>
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            <position position="1199"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS52004"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="2305" mass="251255" checksum="6D3B9BAC82BC8600" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>R0INE0</accession>
    <name>R0INE0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_19016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Wang R."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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                <person name="Han J."/>
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        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA86745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="375" mass="42582" checksum="741B91D78A0C2313" modified="2013-06-26" version="1">MVPRPYFTQDKKVLPFDKVIELERIDDSTFRSIIKAYAPTGEKSGAYGGHVFAQAAWAAAQTVQEGYLIHDITGWFVLAGQSNEHYTYRVQKIRDGYNYCIRTVTVRQVEAKGEMFTCTCSFKREENSSVDVQEQVNLKETFQDALKGKEDEPMEHPSIPSVDSAEFREVYLPAHPEHFNPFGGLHMRKVDMSDYNATRTPLERKQLQFYTLRGSLPLPTAPYPPLPNPGQAAALTREANMHACAHLYASDCHSLFIVPNHLDRPWDFTRMGSLCHSVVFHVGIKDLIMQPEPRIDHPNADPTLWEDGSLPLCNIDGYGQGDKDGRKWFVQESWLTRAAGGRALHRGRLWDYHSGVHIATTFQDGLVRFKDNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPB7</accession>
    <name>R0IPB7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_19329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024898.1">
        <property type="nucleotide sequence ID" value="XM_008026707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPB7"/>
    <dbReference type="STRING" id="671987.R0IPB7"/>
    <dbReference type="GeneID" id="19402185"/>
    <dbReference type="eggNOG" id="KOG3034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068770_2_0_1"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="292" mass="32979" checksum="31253B85F83DB509" modified="2013-06-26" version="1">MAKRKSERDPEELPDASEKRPQQDDDDSGSDEEMDIVNVDFEWFDPQPAVDFHGLKNLMRQLLDVDAQLFNLSELADLILSQPLLGSTVKVDGNETDPYAFLTVLNLQTHKDKQVIRDLTCYLSKKATSIPALPPLLSESSTAQVGLILTERFINMPHEVVPPMYTMLLEEIQWAVEEKEPYTFTHYLVLSKCYSEIQSQLPSGDAPPSKKKNKKADVGQETFYFHPEDEVLHKHAVGYTSFEYDTPVDEGASDSKRAFQEMGVKPKGHMVLIEADKFQGAVEAIKNFLNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQD0</accession>
    <name>R0IQD0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_163135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025612.1">
        <property type="nucleotide sequence ID" value="XM_008027421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQD0"/>
    <dbReference type="STRING" id="671987.R0IQD0"/>
    <dbReference type="GeneID" id="19398672"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006921_0_1_1"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052706">
        <property type="term" value="F:L-histidine N(alpha)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903257">
        <property type="term" value="P:selenoneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="4">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="3">
        <location>
            <begin position="547"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="3">
        <location>
            <begin position="739"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA87110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="839" mass="94823" checksum="2E7D6122AA13A872" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISS0</accession>
    <name>R0ISS0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_168706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908559">
        <property type="protein sequence ID" value="EOA87895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024423.1">
        <property type="nucleotide sequence ID" value="XM_008026232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ISS0"/>
    <dbReference type="GeneID" id="19400641"/>
    <dbReference type="eggNOG" id="ENOG502S3RH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039661_0_0_1"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA87895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="46087" checksum="5E35458E799BB339" modified="2013-06-26" version="1">MAGPITAVNKLALASAVFVIICLLIFSTTTGLRETSTKVVEQLKESAKETTNNLCNNDRPVFGKPSLSDSFFRLYEPIRYPVDEPTYTDASGKVHEVKEDAPWWREPLRNQVLIVDIDTRIPDKENELWNEHRLNWETMKAEGDGGMVSASFMNHFFYAQIHGYDYRFINAADMEGMHNTWVKPHVLYSLLKSYKFVIFIDADATIQHLELPVEWLFNRWGITPDTSIAMPLDTRQILNGDEHASEDSRGKLALNTGVVIAQALPHTFDMLEAWKECPTSDRYPECKQWANEWSHEQKAFSEYIRYDFNPNGTNIVEIPCNDAMGYPGITDHSWITSKCTGQFIRHHTIDKHRTKKSTEAAMMQSLTDLLHQELHGKRDTYLVKEKVVTDTKGNEPELIGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISS8</accession>
    <name>R0ISS8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_176992</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024575.1">
        <property type="nucleotide sequence ID" value="XM_008026384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ISS8"/>
    <dbReference type="STRING" id="671987.R0ISS8"/>
    <dbReference type="GeneID" id="19401507"/>
    <dbReference type="eggNOG" id="ENOG502R701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047420_0_0_1"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05642">
        <property type="entry name" value="M28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="146"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA87671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="481" mass="52252" checksum="13AD55B259F2C6FC" modified="2013-06-26" version="1">MQYLSVLYTAALLYRASAHDIHERNLPPLVAVNDESYTKCANAAWPPSDVGTELVPQAPDAEMRSMLNQVSAANIEATIKKLVSFGTRHTLATYNSSTRGVNAARDWIASGMQKYADESNGTMTVQVQSYLQGVATRIPFPVTISNVLATVKGSEDPSRVYVMTGHYDSRVTDVLNYEADSPGANDDASGTAIAMEMARILSKHQPESTIILGAVSGEEQGLYGSTHFANTLKNASTNVEGMLNCDIVGSSTGDRGQKDPYTVRAFAEGISLTGQSYLTPTLRLQMGGENDTPARELARFSAEVAANDATGMNIAIIYRLDRFLRGGDHTGFLRAGYPAIRYTEPNENFAHQHEDVRTENGTVYGDRIEFVDFEYTARVGKVNLATLWSLSQAPGMPRNVTIDTVIFDNNSRIQWIASDSPDVASYEVVWRPTTASLWTHAVDVGKAGNAILPLTKDNVIFGVRAVGKNGYKSPVVYPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISZ8</accession>
    <name>R0ISZ8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_168904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1778621_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="97"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88286.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA88750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_159891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023393.1">
        <property type="nucleotide sequence ID" value="XM_008025202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVS4"/>
    <dbReference type="STRING" id="671987.R0IVS4"/>
    <dbReference type="GeneID" id="19397991"/>
    <dbReference type="eggNOG" id="KOG2351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110332_0_0_1"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="44"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="169" mass="19167" checksum="56686E15A31A8668" modified="2013-06-26" version="1">MERDADNTASQRPEPPIFKAPRLVSRPKPPVQQDEEMGSDIKLGDFEDVHALSVSEARAVVTAVHEARKKKDPENNPLRDRIYNDSITITQFLDYLDNFARYKEEDSLHSIAALFDAHPEISVVEKALLGTLTPDTAEEATTLIPSLKMDEDELQLILDELNKMQDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVW7</accession>
    <name>R0IVW7_EXST2</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_148505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025377.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IVW7"/>
    <dbReference type="GeneID" id="19396977"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001514_0_0_1"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000018">
        <property type="entry name" value="Lid2 complex component snt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
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    </dbReference>
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        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="8">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="9">
        <location>
            <begin position="591"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1144"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="974"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1325"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1515"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1603"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1658"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="82"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA89985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="806" mass="90071" checksum="85955833D7B0B12B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0L1</accession>
    <name>R0J0L1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_37150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021916.1">
        <property type="nucleotide sequence ID" value="XM_008023725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0L1"/>
    <dbReference type="GeneID" id="19404221"/>
    <dbReference type="HOGENOM" id="CLU_1027328_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="271" mass="28461" checksum="FB87C8EE4F4BEC09" modified="2013-06-26" version="1">MSETLGLMRNHTDGSVPACACGPATRNGGLGAAAMRPFAHCIQSVRPCRGRGRVSGSARSDGSMCGSSRPSWPSSTHRKTRAPDSSGSVASTSQSLAGGQAGRRSNGAYATSRRYWPARSKYTSSLPSAALDPPAQSRPRCTATATPLLPLPHYCHYHTTATPPPPPLPPLPPLLHATHCHPMPPTPPRLPPPCLKPSRRLNSQLARAPLPHLGTEAALPNPHAHGETCSQLAARLPPAHDEQCLPTLLQPVVNAPISPATTPLPSTCQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0Z6</accession>
    <name>R0J0Z6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit sigma-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sigma1-adaptin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_159031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022288.1">
        <property type="nucleotide sequence ID" value="XM_008024097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0Z6"/>
    <dbReference type="STRING" id="671987.R0J0Z6"/>
    <dbReference type="GeneID" id="19397896"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037043_0_0_1"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA90446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="487" mass="55648" checksum="773440CC11CFD56D" modified="2013-06-26" version="1">MTIKYLILLSRQGKVRLAKWFTTLAPKDKAKIVKDVSQLVLARRTRMCNFLEYKDTKVVYRRYASLFFIAGCDATDNELITLEIVHRYVEQMDKYYGNVCELDIIFNFQKAYFILDELLLAGEMQESSKKNVLRCIGQQDSLEDMEYLDLCALHEVNLALNFDTQDTAIIGGCDLWTVKAAGSDKKLYKRIEKTLEERHKDLLSAVAGLSEQSAAQFADQVDISRDTPFGSFSEAANRHTFAYLIATLNATHIDYDFANTLNPDEFRRETMHSFMHKIDTTMYYLRPQVYSAGLPAGAVTPLGSPIWSPRSWQLVDSEMDMSNCEYYAWEPSDDPFADDGAIWSHHFFLYNKERKRVVYFYLRGISALSNSPSVAMSLMSKFKASKYESSANAGSRKRAEYWLGARAKKGLEAYGESDELDNMVIDHPGEVVDAEEEQYLPAREMSMDAEYYYESDGDSDVESLVGRERTVGKVRTMSEGVVEKMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1A2</accession>
    <name>R0J1A2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_167376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022365.1">
        <property type="nucleotide sequence ID" value="XM_008024174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J1A2"/>
    <dbReference type="STRING" id="671987.R0J1A2"/>
    <dbReference type="GeneID" id="19400150"/>
    <dbReference type="eggNOG" id="KOG0846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_5_0_1"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000011">
        <property type="entry name" value="50S ribosomal subunit protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="115"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="331" mass="36299" checksum="21ABA2DACBA06716" modified="2013-06-26" version="1">MPPRLRAVRFVSSLVYSPARSCATPLPAAFVLPAQQRCASILSSLSDNAGAYNKKIRRGRGPASGKGKTAGRGQKGQHAHGKVPTGFEGGQTPQWITNPERGRGKRNPFKVEMSPINLDRIQSWIDQGRLDPKKPITMKELAKSRCLHGVKRHGVKLLARNAEQLTTPIHIVVSRASAEAIARIEALGGSVTTRFYSPTTIKRVLRGESHPIISLQSSPELVSLASRLPTVKIPSPILSALQTAAEEKKSEAMATVMKQVGTKYKYRLPDATARKDIEYYRDPAHRGYLSYMVKQGESPSLFFKPPGEAKDKKKQSAKRDAAKASADNRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1E8</accession>
    <name>R0J1E8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="10">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_144891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="10"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021542.1">
        <property type="nucleotide sequence ID" value="XM_008023351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J1E8"/>
    <dbReference type="STRING" id="671987.R0J1E8"/>
    <dbReference type="GeneID" id="19396789"/>
    <dbReference type="eggNOG" id="ENOG502RPHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_0_2_1"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343749" description="AA9 family lytic polysaccharide monooxygenase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA90805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
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        </source>
    </evidence>
    <sequence length="330" mass="34292" checksum="2EC67A4745750934" modified="2013-06-26" version="1">MFTKALLTTVLLSAVSAHQNLQQFWVNDVSPGRQVGIRMPPSNSPVTDVTSDDIVCNVGGSKGSGVKTIEAAEGDTIKVGWDNSGHPGPITHMLYGPVDDASQATGIGAGWFKIDEADYTNGKWASLLMEQDNMTHTFKLPTVLAAGEYLLRSEMLALHSAQTKDGAQFYIGCMQLKIKGTGSKGACTPQIELPGAYKADDKNIYIPNFYNGFDATDYKAPGGPLATCGGAGGAAPPASNTTAPLPSLAPARPASNSTVPSATPIVPTTFATLVLPSAGITPPVGAVPTGSAGAAKLYEQCGGQNFNGPTTCESPAKCVKQNDFYFQCVN</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <subcellularLocation>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG1840">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28306" checksum="A5D1219A57CED8AA" modified="2013-06-26" version="1" fragment="single">GLNIVAEGQSPVVDIVAVHGLNGHRDKTWTATNGVQWLRDLLPNDIPNARVFCWGYNANTHSKHLSCQYLYDHAKTLVSELCLQRALTGALIHSDAAREGALKEHRSIKTSTYGIFFMGTPHQGGNGVELGKLLLNVASVFVTADDRLIKHLGEQSEWLQQQLGQYGPISRDFVTKFAFEEYETPTIRGHSLLLCFCFSTRYSRLLYRSFPKHQQLSPAQPTLSRLPSMPIIETWSDSNRRRTALTRLSLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_162376</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
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            <begin position="363"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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    </dbReference>
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        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91940.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="375" mass="41541" checksum="9B251A91934FE433" modified="2013-06-26" version="1">MRAFAGGYYRNLQRLYDHLGVRYRQQPFLFDFVHGHAAYFTHASNLHRLPPRPAPVARLRHVAQLLCLAVAYAWFALCCFLVAPARGETLQQYLRRTHTPDLFVTWYLLPLLSSVSTCPHTALLAFPASDIVGYKRDTHGAPHYTVSEGVAAVQARLASGLDVTLNATITAVEPCDKGVRISWTQGPGPGADTHTERFDRVVLAVAPDVVGRIFRPLEHHMCRIPTALVESVVHTDYSVLRASNAPKPGNKNAQLIRLNTCTQQTPKTESHHVQPCGAIVTTCPYTPLDAAHTLHSARFTRVLRTPESQRIVNAMFASEPLSCPDDKAVPLWRNGDDNVWLVGGWCWDGMVLLEGCVVSAMRVAEAFGVTVPWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Zhong S."/>
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            <strain evidence="7">28A</strain>
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    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
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        <property type="entry name" value="ER"/>
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        <property type="entry name" value="GroES-like_sf"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
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        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="2"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA81123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="311" mass="32675" checksum="EE32C0404725EFA1" modified="2013-06-26" version="1">MVTHFPVPGNQSGCDFCGIIEKIASGSTETTFPPGTRVSGGTFPYSRTEAESGAFAQWIAVDSQLLLKVPDNMSDLEGAALGGVGWGTAGLAFYDSEALALDGTPSNPTSTNEPILVYGGATATGTMACQLLKLSGYAPIAVTSTSSASLALKYGAVGTAIYTSPNCVQSIKEIAGGKPVKKVLDCITSEESAAHSFAAIARTGGRYACLEGFNEAFRTRQTIRTKEVMGYEGLGVKIDLGPTPYSREANQTLFDVTARVAAEMQKLVDAGLIKTHPVKEVPGKWEGIIKGLEMLHRGEVRGQKLVVRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLE3</accession>
    <name>R0JLE3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_142012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030396.1">
        <property type="nucleotide sequence ID" value="XM_008032205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JLE3"/>
    <dbReference type="STRING" id="671987.R0JLE3"/>
    <dbReference type="GeneID" id="19396648"/>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026938_0_0_1"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="401"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="187"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA82073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="590" mass="66479" checksum="8DF833B0AB5D8987" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0JM20</accession>
    <name>R0JM20_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_157115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030541.1">
        <property type="nucleotide sequence ID" value="XM_008032350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JM20"/>
    <dbReference type="STRING" id="671987.R0JM20"/>
    <dbReference type="GeneID" id="19397699"/>
    <dbReference type="eggNOG" id="ENOG502QVWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003680_0_0_1"/>
    <dbReference type="OrthoDB" id="10057598at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01236">
        <property type="entry name" value="Haem_oxygenase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="744" mass="83173" checksum="A8E36C99A87F60C2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0JMA7</accession>
    <name>R0JMA7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_22378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
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        </reaction>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Membrane</location>
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    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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        <location>
            <begin position="20"/>
            <end position="211"/>
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        <location>
            <begin position="8"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA82383.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="211" mass="23051" checksum="879BA8450BCB8765" modified="2013-06-26" version="1">MLFPASLLVVPLLTYPVFAQTYTDCDPTKKSCPADPALGTSTYSHDFTKGADDDNWKVTAGSINYTKDGAEFTVAKAGDAPTIKSKWYMFFGSVSFIMKSAPGTGIVSSAILQSDDLDEVDWEFLGGVPENVQTNYFSKGNTKTYDRQANASIPSGNSQTATHNYTISWTKDSLEWIIDGAVMRTVSYAQVNDAYGYPQTPMNVRIGKGRQ</sequence>
</entry>
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    <accession>R0JPV8</accession>
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        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">SETTUDRAFT_55443</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028883.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JPV8"/>
    <dbReference type="GeneID" id="19405212"/>
    <dbReference type="HOGENOM" id="CLU_013929_17_4_1"/>
    <dbReference type="OrthoDB" id="3942738at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7706" checksum="2DF7A4D4ECC87C9C" modified="2013-06-26" version="1" fragment="single">MDPIQEAIAEIESRELGDKFSYQAIAKKHGVARMTLMRRHRGETEAYGVRNLSLHPQHEKELVRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JQJ4</accession>
    <name>R0JQJ4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_180589</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA83443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008030966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQJ4"/>
    <dbReference type="STRING" id="671987.R0JQJ4"/>
    <dbReference type="GeneID" id="19401776"/>
    <dbReference type="eggNOG" id="KOG2018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_9_3_1"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="ThiF/MoeB/HesA"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
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        <location>
            <begin position="104"/>
            <end position="360"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA83443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="503" mass="55291" checksum="F466DE417FA70A60" modified="2013-06-26" version="1">MPSWISKASDSPNARLVATAAVSGFVVGTAILGYQKARRMTRVADLKASIPDLSDDHRPSRLTEYGAASHVFAPSKEDERSMALAARARKGDYDDDLILEQLARNRVFLTDEGLAKLRNAFVIVVGCGGVGSHATAALARSGCAKLRLIDFDQVTLSSLNRHAVATLADVGTPKVHCLRKRLEQITPWTHFECRNELFGEQTAAAQLAPLNGQPPDFVIDAIDNIDSKVALLAYCYMNNIKVISSMGAGCKSDPTRIFIGDISASTDDPLSKSTRRKLRLKGVKDGIPVVYSTERPGPGKAELQPLSEEEFAKGNVGELGVLADFRVRILPVLGTMPAIFGLAVANHVILSISGYPQEYLPSKSRDKMYDGILGALQGAEERLARTIFNEDPLGLKIPLTQDDVGYLVEEVYSGRSIISGISTRLILSRWRKPAKSFVDQSIPGQKHSHLEMKDLVLMTKEEASKHEKEILKGEKSLEDLYSAETIERVNKRMAEEERFERFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JS50</accession>
    <name>R0JS50_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_164289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008030192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JS50"/>
    <dbReference type="STRING" id="671987.R0JS50"/>
    <dbReference type="GeneID" id="19399080"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051532_1_1_1"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="265" mass="28495" checksum="BA6EF2506ABC3F7D" modified="2013-06-26" version="1" fragment="single">MPVLAFLSHRHALGTLSTKTCIYPFHSVPLISVLDGFAVFVNSSAPNTHASAIWKVTPLFANWIASPTNFLFTTSLLSSSSTVLELGAGVSGIVALSLGPSVGHYIATDQAYVLKLLRQNIAENLETVFPPQRKAKNAKGGGGKRGGNASDAAGSGDRITTLEQDWETDSVAQLPPVDLIVSCDCVYNEALIEPLNSTCAAICKLRDGEEKPTLCLIAQQLRSPDVFETWLKSFHDKFWVWQLPDAMLGEGLREGSGFVVHLGIV</sequence>
</entry>
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    <accession>R0JSE5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_496957_0_0_1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="588" mass="64624" checksum="611A25D4D6A272C7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0JTE2</accession>
    <name>R0JTE2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008033233.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S7FM">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    <sequence length="326" mass="36789" checksum="3D184B9E28E39D63" modified="2013-06-26" version="1">MAFFISPTWRLPKVVWFLIVFELPFTVANLALFGIASPNLYRTILWRIGGEMGFNSQPSTVLYAYANYRPVKIPLVWSNFNTQYHLVIGVVCTFFWLVKVTLWLLKVLYPVLSLPLHIALMCLWAYGIHVQTAPDTIDPDHMNKGAPWYITKNCNIVQDDRIRGYCMQAKSSFAVSVIMLSIYAVFVIMSIYSLIPTAAQKEAHAARKAEKKAEKEKWASSPYDNEMTAEEQWQHMWELQQLPRTPGTMGGIKSPMTPRTLAFNSLGGEEAGQGGYYVPAGGNGWYAPPQHGGVPTQTVSPIMEQDDYQYNHEGKGKTMGWNGNAY</sequence>
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    <accession>R0JYJ8</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS quinate transporter QutD"/>
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        <property type="entry name" value="SP"/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA82704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZ24"/>
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    <dbReference type="HOGENOM" id="CLU_2795577_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="68" mass="7489" checksum="C01395C18380ABD3" modified="2013-06-26" version="1">MDNIARAVSLPPDPPTRSCLRAPISPERPCGCPASLAYHTSRHLQRFSNASPRPFKAKSTFATYMPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZF8</accession>
    <name>R0JZF8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_43657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029506.1">
        <property type="nucleotide sequence ID" value="XM_008031315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZF8"/>
    <dbReference type="STRING" id="671987.R0JZF8"/>
    <dbReference type="GeneID" id="19404865"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_1_1_1"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:negative regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA82844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="174" mass="19171" checksum="C7B1529F225419D3" modified="2013-06-26" version="1">MSQVIGKTRLAYARSWHHLDIGSDPRALGRVASAIALTLMGKHKPIFDPSTDCGDYVVATNCAQLHTTGKKRSQKLYRTHTTRPGSLKEISMDKLMQKWGGGEVLRKAVSGMLPKNRLRKERLARLKTFEGNAHPYKENLLVVGNGGGQSIMDHHDVKRTFAQSKPQDAAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0I1</accession>
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        <recommendedName>
            <fullName evidence="7">ORC6 first cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_122060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030325.1">
        <property type="nucleotide sequence ID" value="XM_008032134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0I1"/>
    <dbReference type="STRING" id="671987.R0K0I1"/>
    <dbReference type="GeneID" id="19395867"/>
    <dbReference type="eggNOG" id="ENOG502SAT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045412_0_0_1"/>
    <dbReference type="OrthoDB" id="5367324at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA81967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="353" mass="38694" checksum="C7971417837D9394" modified="2013-06-26" version="1">MSRASIEQALTGLVPTLSGPLPPELIELALSLLTRSQTVATSLKSDEEIARPYACAQLACERLKKRLNLPSITSRPPCPPRIYKKLYNYLSSALPDSFANSEPQTPRKKAVPAPAASVRNTPKTPLSTKRGRESNAEPPEWVVPAIRALAKAFEYPAVIPHVYTGVESIYPLLARMSAAAAESPSKRPKRATASALSSADVSDTRLLGLIVVVFLLVFSRMRDVDVSVDKYNEWLVKATSTVLKNPSAQHVTSEELVPVIEQTMAMAKEEGWLQMQWFESVKPVADGEEMEGVEMTGNMNVKSGALHLRSGSPYIGLGTMMQDATDYLGERQQEDYAKWKAQILARVENIEAA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="8">Malic acid transport protein</fullName>
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            <taxon>Dothideomycetes</taxon>
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                <person name="Henrissat B."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Bushley K.E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K5A9"/>
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    <dbReference type="HOGENOM" id="CLU_858338_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="324" mass="34057" checksum="59BE53FC39A51CC2" modified="2013-06-26" version="1">MGFFNIFKSASIPPPLYLRTLHLPTHLPTLVYGSPGNPNSFLSPIPPRAAPSHNDPSASRSVSVLAVVPVEANPRFPTRRGVSVRVRGPVAGHGSGDGRVGNENASSHGAGNARGNPSHGALGNTASGRNIAPCTRSVSGIQRGIAGAGFRFGASLEPGERRAGAEMSTSVGMGMDMDMGRGARARGRAWAIHRGYGRGRDRGHGHETIRHQDENEDIFPPHPRTSSAPAPDVSARFAPEPNHHRGNGRGSSADPVQISRDTTDIRRARDGFSSVPGRAYSVRGRGRAGSERARPSVRPFAGVGSSGLGDMRGRGAFGRRGPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6F2</accession>
    <name>R0K6F2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_137461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027571.1">
        <property type="nucleotide sequence ID" value="XM_008029380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6F2"/>
    <dbReference type="STRING" id="671987.R0K6F2"/>
    <dbReference type="GeneID" id="19396413"/>
    <dbReference type="eggNOG" id="KOG1167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA replication initiation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903468">
        <property type="term" value="P:positive regulation of DNA replication initiation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060903">
        <property type="term" value="P:positive regulation of meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905263">
        <property type="term" value="P:positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905342">
        <property type="term" value="P:positive regulation of protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904968">
        <property type="term" value="P:positive regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="73"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA85094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="458" mass="52555" checksum="743D9BC28741E934" modified="2013-06-26" version="1">MAKARTLLRNGEGIDVHEDPIKAEDAEETMDESMDPLDESGQTVDTSDEEVEDAVQEDMARFEETFVGISKRFRLINRIGEGTFSTVYKAEDLEYHKYNNSWDVDERENSKWMSPSRRKQSGRRPHYVAIKKIYVTSSPIRVFNELELLYDLRDSDSVCPLITAFRHLDQVVAVLPYFQHRDFRDYYRDMKVSDMRPYFRSLFTALAAVHQKGIIHRDVKPTNFLYNTSQSRGVLVDFGLAEREGTDWHNCACHMNEEDRRHRISHSVYAQTQSAGHNAAAYPKNDTRNSRRANRAGTRGFRAPEVLLKCTQQTCSIDIWSVGVILLTMLSRRFPFFHSADDIDALLEITTIFGRKKMRETALLHGQVFETNVPSYSEGGHSLEKIILWCTGRTGDKTQPKKELEEDEKEAVQFLHRLLECNPAKRITAAEALQHPFLANAHEESEAEPNESADAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0K725</accession>
    <name>R0K725_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_176233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">28A</strain>
        </source>
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        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA88798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008025273.1"/>
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    <dbReference type="STRING" id="671987.R0K725"/>
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    <dbReference type="eggNOG" id="KOG3394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MRH_dom"/>
    </dbReference>
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        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343138" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="17"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="148"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="85"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="243"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="511"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA88798.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="528" mass="58689" checksum="25F6DC7E47A63CF6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="98" mass="10940" checksum="AA56D61D7FD10560" modified="2013-06-26" version="1">MSGIETSPNTTHAPSEQPAIEEPTRRKQLTCILCQSDQVPLASNIPSRLGERHATKYLFFGQTESQPLVSDVPVTRSCPYKPYYASGRIRHGSFLIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K860</accession>
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            <fullName evidence="7">Ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_154191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008028945.1"/>
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    <dbReference type="AlphaFoldDB" id="R0K860"/>
    <dbReference type="STRING" id="671987.R0K860"/>
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    <dbReference type="eggNOG" id="KOG3419">
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="FunFam" id="3.30.1320.10:FF:000012">
        <property type="entry name" value="37S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA84507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15075" checksum="D84E97FA3037863B" modified="2013-06-26" version="1">MVLRIRLARFGKKHAPFYNIVVAHARTARNSRPLEVLGTYDPKPQPPRPGDTHGRPWKDIKLDISRARYWVGVGAQPSDTAWRLLSMVGILEPQYRIGQIQGQVVKADSAYKSLIPERPKNKVENVGGGANKVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8J4</accession>
    <name>R0K8J4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_159684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023098.1">
        <property type="nucleotide sequence ID" value="XM_008024907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8J4"/>
    <dbReference type="STRING" id="671987.R0K8J4"/>
    <dbReference type="GeneID" id="19397966"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA89278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="261" mass="29965" checksum="87FBBDA81217E020" modified="2013-06-26" version="1">MSWTGFKKGVNRATTQVLMKTGQVERTNDRDFETEQRRYRTMETAANKLQKEAKGYLDSLRAMTASQMRIAETIDAFYGDAGTKDGVSRSYKQAVTDLDAETIKALDGPYRTTVLDPIQRFCSYFPDINACITKREHKQMDYDRMRAQVRKLTDKPDKDVTKLPRAEKDEQLAKAVYDQLNDTLTTELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDANTRDQYAQGELDARVEEVLQEIRDLSIAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9K0</accession>
    <name>R0K9K0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_167479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022615.1">
        <property type="nucleotide sequence ID" value="XM_008024424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9K0"/>
    <dbReference type="STRING" id="671987.R0K9K0"/>
    <dbReference type="GeneID" id="19400192"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083737_0_1_1"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    </reference>
    <comment type="similarity">
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    </dbReference>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="452" mass="50153" checksum="1CAEB6CC1D23565F" modified="2013-06-26" version="1">MEDVHRELLPEELSAALKVMVYLQEKTIIEQDTPAESITAWLQARVLPHAEDTTCIPKAPPIPRKRLCYICRLAITRAFPSHPSLCVPCGAFNHASSQLSMPPRLTLPRTFTALVTGARVNLGYHTALRLLRCGAQVIATTRYPHDAIVRYIQEPDSHLWEGQTQGGGRRFQQCLRQWADGGDARLYALINNAAQTLTDSVKKEEHATQREEELRGRVKHHTFLIERSYKARVRGGALPLALESGESTCIERLEGHGDAMWSLDASKASTTEMEPYSKSSWVQGMSEIPYEDVGSALSVNTFVPFILCRELVPLMGTTEPLPPGTASKPQGYIINVSSREGIFEDHITSSAKRGKHVHTNMSKAALNMLTETEADPAWRTRKVAMNTVDPGYMSAAPEYEDAFDWTRPIGWEDGAGRVLWPIAVGEVEGQVVRGRFLKHYGAVEVDPGMGRG</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86164.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="241" mass="27635" checksum="BF73A322EF9BB782" modified="2013-06-26" version="1">MTRLTPRKRESKWAQWARRESRERTQQRLVIPGQTGNAAALNPVATPPRRSYAGKSFSQTRPQVTTPPRTGPRPRRQGIKSPSSPVPLSSTSSVSGDLALTPTRFPKQDKSYHSVLQNHPTATDLLQEQIARQQAAALERERAEKRKEELRKDPSANYRHILEVYKLIPLDRKHGELPSPYLLRLLANRPMPDDEESELALAIVYAKDHWGDFAMWPQDTKRYADYERERRKKEKVGVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KB16</accession>
    <name>R0KB16_EXST2</name>
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    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">28A</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <topology evidence="4">Single-pass type I membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="5">Belongs to the ATG27 family.</text>
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        <location>
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            <end position="26"/>
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        <location>
            <begin position="27"/>
            <end position="363"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
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            <dbReference type="ARBA" id="ARBA00005363"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
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        </source>
    </evidence>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA85442.1"/>
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        <source>
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    <sequence length="363" mass="40730" checksum="F22AE70C52A154D9" modified="2013-06-26" version="1">MAPSRPRASLLSLLALTPFLPHSAWAFDCKDILADGAHFNFKDLGGPHVVHWEESEIEKELKFKYNFTLDICNPLKWHKGGSLDTECHHGARVCGIREMIDLNKDNNLTITPIDIAGTYALQNGRKIDAKFENLGHSKSNSDAREGVRATLNGGRFPFDDKKEGMDQRAIIEFVCDKDRSGLEGGEKDDSPHEDGDKDEKENDGDKKKDDEKKGDDKKDDKKDDDKKGEKLKTRNDNTKGKCEDSDASLRFCGYEVETEAKDKKIRTLRLEWRTKYACADAPEPDSGSSWGFFGWFFIVVFLGIAAYLIFGSWLNYNRYGARGCDLLPHSEALRDIPYIAKDFARKVMDTVQGGGARGGYAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="490" mass="54136" checksum="F228E64DBAF80456" modified="2013-06-26" version="1">MPKAPKSPGVRDQRHNPLAEEYAPSDPWKNKGPKRQKRSKGEKDEDEQKYVDSKSSRKILEIGRELEEEDARESKAQRPQEANPAFDFETRLGEDDMVEGDVQAEDDDEAWGDDDEVEEVEIDANDLAAWNKFIPTDDNPIVWPGQEAQPSGQGTDLAALILEKIAAHEAGGEVQQPEIQGGGAPEDAIELPAKVVEVYSKIGLILSRYKSGKLPKPFKILPTIPAWETLVAITRPDDWTPNATFAATRIFVSAKPQTAQMFLNTILLPLVQQNIRETHKLNVHLYNALKKALYKPSAFFKGIVFPMLTDISCTQRDAAIVASVVAKVSVPVLHSAAALHRLCEIAAEQMSSDPDAAGPCNMFIKTLLEKKYALPYKVVDALVFHFLRFRGVGASSADVMDTESVAGDLGNTGKLPVIWHQCLLAFAQRYRNDITEDQREALLDLLLTRGHRSISAEVRRELLEGRGRGVVVEPQAVGIDGDDTMMAVDS</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="113" mass="11905" checksum="47CE87772F572417" modified="2013-06-26" version="1">MKAPSSSSVALVLTFLSPNANIFANADRLPVTAGFNPYIPSALCCNTDFVWTPFNTPNGQGPIWSWQYCCKLGTDPNSGNGCDGDDGFNVGREQLSKFYGPGCGGGAVQVYGN</sequence>
</entry>
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    <accession>R0KE00</accession>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023539.1"/>
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    <dbReference type="STRING" id="671987.R0KE00"/>
    <dbReference type="GeneID" id="19399975"/>
    <dbReference type="eggNOG" id="ENOG502QT3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="KPA_reductase"/>
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        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="323"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
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            <end position="503"/>
        </location>
    </feature>
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            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91078.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="83820" checksum="AF28F5DFB51397A9" modified="2013-06-26" version="1"> </sequence>
</entry>
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    <accession>R0KE47</accession>
    <name>R0KE47_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_169199</name>
    </gene>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908593">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10265971at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
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        <property type="entry name" value="MGS207 PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
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    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="430" mass="48666" checksum="3C66C9AEA942CBBD" modified="2013-06-26" version="1">MFSLPRISLPSFLRGGAGSYLAVDLPSVQVHDIETAADKRPRTLKHLLKANHANHAIIYHNLTFHNHTPHILGSAYLLGGTAEHLNDIYEKEAEQLEPWHDAPGEITKDDWRDFLGKREYQRAFIDFFEDQLVTKRYSVEEVLDEFLFEGKEPLINGIICGLAHPLIHLGYAYELNSKTVAIEALAMGACFYSSLHKYIDDPKYTKPSPHSTAGAQSSLVDILEKVRQDARFDGLYDHRSGDISKVLEEQEEAFLEYWNAWEITNPNEQFRAAQELGAGLLVGTPAPAPGQYDFFIVHVLTSSHAIRILLPLIPAKFHVSLLRQWWLFALAVFIAQTRPEIDMDKLMLMEDSKKSWKHVVDRALNGPHAIDAPYVKALRAMKVAEETWGASENESSHWLKAAVKFADEFEGWGGFGMAEDEARMAYPENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEG9</accession>
    <name>R0KEG9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_112904</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022366.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0KEG9"/>
    <dbReference type="GeneID" id="19395575"/>
    <dbReference type="eggNOG" id="KOG0391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_24_2_1"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000655">
        <property type="entry name" value="Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025330.1">
        <property type="nucleotide sequence ID" value="XM_008027139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KF34"/>
    <dbReference type="STRING" id="671987.R0KF34"/>
    <dbReference type="GeneID" id="19398581"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="505"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="720" mass="81778" checksum="292B7301186A2E9A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFP9</accession>
    <name>R0KFP9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">SETTUDRAFT_85857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020431.1">
        <property type="nucleotide sequence ID" value="XM_008022240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFP9"/>
    <dbReference type="STRING" id="671987.R0KFP9"/>
    <dbReference type="GeneID" id="19405553"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_3_1_1"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lucas S."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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                <person name="Condon B.J."/>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023744.1">
        <property type="nucleotide sequence ID" value="XM_008025553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGL9"/>
    <dbReference type="STRING" id="671987.R0KGL9"/>
    <dbReference type="GeneID" id="19404362"/>
    <dbReference type="eggNOG" id="ENOG502SHCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_1_0_1"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354179" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="43"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA88424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="353" mass="39403" checksum="E1BBE41DB54122BB" modified="2013-06-26" version="1">MRFSNVLASLAIANSALASPFPPPNDSPDSLYKSMLAAGKQFMGTALTLRNSSEEDAIIKSDFNGFTPENAMKWESTEPSRNNFTFNDADRYAAYAKQNKLQVHCHTLVWHSQLPLWVSNGGFDNQTLIGIMENHIKTLMTRYKSVCTRWDVVNEALNEDGTYRPSVFYNTIGEAFLPIAFRLANKYRGKAELFYNDYNLEYNQNKTAGAARIVELIKSYGVRIDGVGYQAHLASEITPTASSVTPDQATLEAALRHTADLGVKVAYTEIDVRMNTLATPEKLQVQADAFERVAKSCIAVKKCIGMTVWGISDKYSWIPGVFTGEGAALLWDENYQKKPAYFGFLKGIKSKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGT1</accession>
    <name>R0KGT1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_163241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025700.1">
        <property type="nucleotide sequence ID" value="XM_008027509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGT1"/>
    <dbReference type="STRING" id="671987.R0KGT1"/>
    <dbReference type="GeneID" id="19398703"/>
    <dbReference type="eggNOG" id="ENOG502SHX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006237_2_1_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50689" checksum="504222B9557D891C" modified="2013-06-26" version="1">MNGLNNVSMSQGLESRSSTEDIQDAPNTSIDQDMDECIDLMSKLDLAIEADGPPVHLESGLRLIHSLRSRMAVSRQSRHSKPVPTRYGRPWRPPAMRLEEADRATVDLLFWLGVTFDTLSAAMHKRSLVVSDEDSDIVLNETMQMNGPGCPETTPAFKTESDGLWDGYLFARQQQQVEQAPIRWPCSFEQAATTLCEAAPVKVLLFRRVCRIQTLLTRSARGTKVEEAVRAALDVCNHWDTLYAPFVRDCIQYHDRLPPRVQSWYVCVAGHWYLATLLLADLMEVVDESEMGLQHATEQRNLSAFIAKFRENNCRALSDLAGCACPRQDASLQQSHAFHFAMNEGPLLTDPWTAVLIRAFAKAGVLLLESEALLPCDVDQEDAFRRADDCIKALWFLGRKSDMALAAARILGDALKQRRKSAQDRVNDMSFFLESQLWHDLDGAFAVDCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGZ9</accession>
    <name>R0KGZ9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_168404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023934.1">
        <property type="nucleotide sequence ID" value="XM_008025743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGZ9"/>
    <dbReference type="STRING" id="671987.R0KGZ9"/>
    <dbReference type="GeneID" id="19400537"/>
    <dbReference type="eggNOG" id="ENOG502QT50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079101_0_0_1"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
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                <person name="Bushley K.E."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022850.1">
        <property type="nucleotide sequence ID" value="XM_008024659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLG0"/>
    <dbReference type="STRING" id="671987.R0KLG0"/>
    <dbReference type="GeneID" id="19395064"/>
    <dbReference type="eggNOG" id="ENOG502SHGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_3_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA89979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="620" mass="69914" checksum="BEB332B21BBB320D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQM1</accession>
    <name>R0KQM1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_167058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022026.1">
        <property type="nucleotide sequence ID" value="XM_008023835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQM1"/>
    <dbReference type="STRING" id="671987.R0KQM1"/>
    <dbReference type="GeneID" id="19400023"/>
    <dbReference type="eggNOG" id="ENOG502QVVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_8_2_1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000100">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="53"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="479" mass="54550" checksum="565E2F3ABEF3DC9E" modified="2013-06-26" version="1">MRYRYHHGTNLGSVYVIERWLQNSRFPEGAEGSSELSAVKAWVDRIGIAGTKQKFEEHWANIVSEDDIAWLADVAKCTTVRLPIGYYDLPGPVFTQGTPFEPYAEVYAEAWNSILTLILRLRTRSIGVLLDLHALPGGANAQEHSGTNSGRAELWPSPANRALGLRCCQFIAEDTKFVAELAGLQIVNEAEWGSEGMYEWYDECIAAISAINPEMPIVVSDGWDLGRATEWALQKNSVYAHPLCPVVVDTHSYWAFSDEDKAKSPQQIITEAGTKLRELNSKEGPIHERGAVQVIVGEYSCVMTEDSWAKRGDMPREELVKHFGQVQSKRYQERAGGSFFWTLKMDWMPGGEWGFQAMTEYGSVVPPDYRTISANDKRAMIEHALSVKEDRWGLAFHQHVLYCSGLDPDGRYEYVKFWYGWQLGYQDALEFFKRGDRIGMLELWFLKRIRESGYRGGFTWLFEQGLRRGVQDCYAVFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KS99</accession>
    <name>R0KS99_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_166599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021436.1">
        <property type="nucleotide sequence ID" value="XM_008023245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KS99"/>
    <dbReference type="GeneID" id="19399864"/>
    <dbReference type="HOGENOM" id="CLU_2980569_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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                <person name="Han J."/>
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            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="12" type="ORF">SETTUDRAFT_166441</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
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        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <source>
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        <source>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    <sequence length="427" mass="47372" checksum="EE5F3694393F0251" modified="2013-06-26" version="1">MLLPTRHPRHHALERRALSKQARTFVVIGVIAVVIFAILIITYFTTRKFRASSRGTRKAQQASKDKLPSLFSWKYFRKRPRRNGYSTTLQDTEYRGSASRASGEMSGATPADPERQIGSTAANGVDRNTSIRSVMTLPAYSSAARENERVLGREGERAGMDNVIELPETQDEEERLREEEMESLYQIRLARRIEAAEREARRQARREARARGDAQALADIRRRAEQAADLSISQMLIAEHQARQRSRDHRVSSVAYGDLGVARHDGTRLRANSSESDNRPLLDSAASFSGVSGRSRGYTATSNETHQRGLSVTSLAQSVESHGSDDYDFADASRTNSQTHSHTNSEGFEVIPLHPETSHSGSSAPSPHADIPTEDAPAYEDPPNYENPVNDRAPQLPALNLDLERLPSIQVTTEPTPVDGRAPSPLR</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ciuffetti L."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
    </reference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Kosti I."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="198" mass="20947" checksum="EB2BBBFFDF034C80" modified="2013-06-26" version="1" fragment="single">MRFAPAFILASVFVTASGQFIIGALVLIEFTVEFLEAAEVVATLDATVDIGITADEVESGDILLTAEETSTSGAVTIRSSPHVQEVAHSVSGRLSLQPVPAGASTSTGQFALDVEPFVLNPETAYPHVRVEIDWLADFARTARHGPGSSSTPGFSMSNLRLGRPNYSGYGGRGELNVDTKDFVSADILTSMSLSRLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="637"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
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            <end position="824"/>
        </location>
    </feature>
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        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="61"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
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            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <end position="957"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    </gene>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008028308.1"/>
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    <dbReference type="AlphaFoldDB" id="R0ILK7"/>
    <dbReference type="STRING" id="671987.R0ILK7"/>
    <dbReference type="GeneID" id="19400928"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_008964_7_2_1"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006897">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000266">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016559">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Dynamin_GTPase"/>
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        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
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        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="33"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="607"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA85950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="694" mass="78044" checksum="CF56DFF53F021012" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILN8</accession>
    <name>R0ILN8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_111387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908648">
        <property type="protein sequence ID" value="EOA85721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026666.1">
        <property type="nucleotide sequence ID" value="XM_008028475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILN8"/>
    <dbReference type="STRING" id="671987.R0ILN8"/>
    <dbReference type="GeneID" id="19395485"/>
    <dbReference type="eggNOG" id="ENOG502S2XP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037431_2_0_1"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA85721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="464" mass="51716" checksum="0A422121A202F10B" modified="2013-06-26" version="1">MTEAWKALEQCLPPRDSNSDTWWQLTGRHLATILDAAGYPVEKQYEALLFHYHWTVPYMGRAPGQPQRSPSEVAWKSLLALDGTPIEYSWKWNTAEDGSLPNVRYVVEPIGRDAGTELDPLNQQASRELLFKLKRILPGMDNTWACHFFATLFDHDHAVFMTEAARGGHLGTSVQLAVEFHDKATAIKSYFFPRKYGQAGLMPLEQWRMCVDELKAGHKSDSGAPAAAFSTPARTAVDQFLSTSPYGQKLTPISLAVDNVTPEASRLKWYFHTTQTSFASVRHIMTLDGAIASPKVDQLLDQLASLVNVVNGLEDKFPEDAEVPAGSELETSLDFGELTQALKGYLYYFDIAPGKAVPEIKLFVPTRYYGRNDLVLGRALTRWMEANGRGSHCQRYLEMLERLAGHRRLDEGKGLQTYVSCLFKKGELDITTYLGAEAFHPGRLGSTGGGLLTKASTLRRGDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILS2</accession>
    <name>R0ILS2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3'(2'),5'-bisphosphate nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_169550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908637">
        <property type="protein sequence ID" value="EOA85766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026566.1">
        <property type="nucleotide sequence ID" value="XM_008028375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILS2"/>
    <dbReference type="STRING" id="671987.R0ILS2"/>
    <dbReference type="GeneID" id="19400940"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_1_0_1"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
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            <position position="70"/>
        </location>
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        <source>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0INR9"/>
    <dbReference type="STRING" id="671987.R0INR9"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="234" mass="25756" checksum="7E46D009E357C882" modified="2013-06-26" version="1">MNSFFYSVKSSAKRVYPVPDGLDEKDVVAILHDHSLLSQIFWPHSMAAVRAEQPGNSSSSRPGESKFQVVEQNGGLSFKAAICSQPGGAVSCTEELPVGSHITVSYALVRGDELGDYEKQEEEEEEEEEEEEEEEEEEEEEWASDTASTLLETKDARNDDRLWLAEQRSMTTFKVFSPFVKLKEGGFVLKTRNLLRVLQSLGVHGRDMAGALAELNGARLGADGDAGLGKAKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0INY6</accession>
    <name>R0INY6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="5">3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_151100</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="5"/>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026073.1">
        <property type="nucleotide sequence ID" value="XM_008027882.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0INY6"/>
    <dbReference type="GeneID" id="19397103"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="19">
        <location>
            <begin position="227"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="18">
        <location>
            <begin position="685"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EOA86481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="915" mass="103753" checksum="1DA49D0FD90C8D3F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0INZ7</accession>
    <name>R0INZ7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_162871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025284.1">
        <property type="nucleotide sequence ID" value="XM_008027093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0INZ7"/>
    <dbReference type="STRING" id="671987.R0INZ7"/>
    <dbReference type="GeneID" id="19398568"/>
    <dbReference type="eggNOG" id="ENOG502QPRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_0_1_1"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353168" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="113"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA86655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="378" mass="41508" checksum="865510EF45198C14" modified="2013-06-26" version="1">MVQFTHALAAALLATGAIAHGDVNKEILRRRAHLEHPYRRSVLDCKRDLEASGWARKNLERREARLNELRVEAGFAKRDELARREPQLYNPDARTAQGCTTLDQEQTEGPYWVSGELIRQDIVTGEPGVKLHLDINVIDVTDCTHVVDTFVELWGANSTGVYTGVQSVVNGDGSASSLSSNALRGIQPTDANGTARFITVVPGHYVARTNHLHTIIHQGAKLLPNNTIEGGVIPHVGQFFIEQDWLDRIEKTDPYNTNKQKVVLNKDDGLYVWGFKGGDNPNIQLSLIGDKIEDGLYGTIDVGINSTYRLDPSPVNQWTDHGGIPAEGSLWKGYPNPATCIGCRPQNDTAPQSSSSPSPSPESSPEPPHKIVDLDLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQA3</accession>
    <name>R0IQA3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_163029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025468.1">
        <property type="nucleotide sequence ID" value="XM_008027277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQA3"/>
    <dbReference type="STRING" id="671987.R0IQA3"/>
    <dbReference type="GeneID" id="19398627"/>
    <dbReference type="eggNOG" id="KOG4163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="88"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA86911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="562" mass="63024" checksum="479FA9A6977D602A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQM2</accession>
    <name>R0IQM2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="8">HIBADH</shortName>
            <ecNumber evidence="3 8">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_163099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 8"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025556.1">
        <property type="nucleotide sequence ID" value="XM_008027365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQM2"/>
    <dbReference type="STRING" id="671987.R0IQM2"/>
    <dbReference type="GeneID" id="19398660"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000630">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="69"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="241"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA87026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="373" mass="39594" checksum="7FA592B12C1DAC9B" modified="2013-06-26" version="1">MQNAETASNRSPQYISDLDDNPATSALYNDTMRTVSALASTVQRRTPIAVRQGTRRCFSSSQNLQATWGFIGLGRMGYPMAKNLRAKIPAEDTLFVHDVNTAATKQFLEEHPQGVQVAQNVRELAENAETIVTSLPEPKHVKAVFKEMLEPPTLLSDGVVKKERFFIDCSTIDPMTSGEVAHTVHSTGQGKFVDAPMSGGVVGAQAGTLTFMIGAPEEAVEGATKVLSLMGKRVVHLGGPGAGLKGKLANNYLLALNNIATAEAMSMGVKWGLDPKALAGMINTATGKCWPSEVNNPVPGVIEGSPASRGYEGGFGIALANKDLKLALKAAAEADVKLALGEAARALYDAVEQAENCKGKDFSVVYRYLGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IS00</accession>
    <name>R0IS00_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_169046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024834.1">
        <property type="nucleotide sequence ID" value="XM_008026643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IS00"/>
    <dbReference type="STRING" id="671987.R0IS00"/>
    <dbReference type="GeneID" id="19400767"/>
    <dbReference type="eggNOG" id="ENOG502RXIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_0_0_1"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353250" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA87620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="354" mass="37475" checksum="98822940BD1C4B9F" modified="2013-06-26" version="1">MRFQLRAALIAALGLASSADALKILMGNDDGFGSGNLRELYKLLVGAGHEVLIVAPAQQQSGKGTTVIWSESANLTKPSQYDIVPAGSPSVGRDPSDKNIWYYDGTPAACTFVALDYVLPRYYPEWKQTADLFIAGPNYGTNLGPFVMALSGTVGATFAAISRSIPGIATSASNKAVPYFNVTGPSHPAAVAAKVTFEVVNEFIKNTPKDQKVLPLGYGVNVNIPDLVNGTMPPVVKTRLTGNANTDVAVYDETTGLFDWDNVDPLAAGINAQYNGDTSLPDETWAVAGGAIAVSAFTMDWSAPDIGYTDAVYAKVDGLLSESSTVNKSGYSKRMVEERMRKRGVMLTGRDGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISH6</accession>
    <name>R0ISH6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_168914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <end position="128"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA88231.1"/>
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    </evidence>
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        <source>
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    <sequence length="194" mass="21554" checksum="585CB2DEA36FF001" modified="2013-06-26" version="1">MEANAPNLNVEELAAYATTKSQAGVPDEEILREITQMLREDGWKEAAIGPTIEAVVKRSSVVGGKGSPRQEGSPKANQNAVAQVMEQMMQLLSLMASRLEALERNQAEGRSESSPRVDTPPPPLTTVAEPAARKNKFPDLERFNGTRDNYLEDAKVQYVLSRTKGKANQVLLLWVLENKERTTAGLWEHMDTYF</sequence>
</entry>
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    <accession>R0IUL2</accession>
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        <name evidence="23" type="ORF">SETTUDRAFT_168365</name>
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    <organism evidence="23 24">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
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        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
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    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
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            <topology evidence="2">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="19">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29646" checksum="AB647F106F4CC103" modified="2013-06-26" version="1">MERKRSAVSQTSDAAPTDSTDTFHEDPTSQARKLRLSNKLVDRACAYSGLLYTSFSFIFFIASGNFPPAAPTLTAEQVVQHYHDHNVGYKVGASFFLLAGAFYGSFTAAMSQQMKRIPGVGHTLISAQEVSGAWACITFAVPAIFFATTAYRLDRPPEITQALNDLSWLMTFMPFAPFIVQGWAFAGAIFLDQRVKPLFPPLVAWVNFVSPILLGSGIAMHCVKRGPFAWNGALTFWLTAVVFGIQSVVNIFYTLKAIETETTAELEAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVY6</accession>
    <name>R0IVY6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_27004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023299.1">
        <property type="nucleotide sequence ID" value="XM_008025108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVY6"/>
    <dbReference type="STRING" id="671987.R0IVY6"/>
    <dbReference type="GeneID" id="19403078"/>
    <dbReference type="eggNOG" id="KOG0427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_15_0_1"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA88955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="148" mass="17163" checksum="6E732ABCEE8457DE" modified="2013-06-26" version="1">MFAAKRLGKMHEKLPPGITLVKADDFETWLMDIQVMDANPIYQGETYRLKFGFSPQYPIEAPEVVFVRDETHPIPWHPHIYSNGIICLDLLDRSGWSPVHNVESVCVSVQSMLTSNTKKERPQGDENFVRYNTQRPRDISFVFHDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IW42</accession>
    <name>R0IW42_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_128580</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023492.1">
        <property type="nucleotide sequence ID" value="XM_008025301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IW42"/>
    <dbReference type="STRING" id="671987.R0IW42"/>
    <dbReference type="GeneID" id="19396054"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_3_1"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353287" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="20"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Hamelin R.C."/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="425" mass="47158" checksum="09A2D03B75087856" modified="2013-06-26" version="1">MTGETLADEKTPQSPASPASPTNTDTDATLAGDGFVETAEDAHSTIQSSVRTDSIDIESAQPQGRKKRPQLLKRITKPFCSDPEPEYVTENRTRKLEQTPNGFPRLAAFQSSEPNFSLYRSFNYLHSRVLLDLQDEITSLEKELDEIDWDDYDQDANRLKCRDFDSQQPDGDGAPRTRRIVLGEIKSKLIEYDEVLIKARTLESFQRPSDRNYRSVRRYCHNEKPLLDAEMDALRSKEDIVSLHNGREWATFDGGVETLIGQIDRVLRKVFRTESLPLQKYFRTPEAQEKTTNPYVSFYSSSRIDKLVNVLITIVIFALLVVPVVTMYQLTNTAAHYESPSSPSSSSSAASSSSAAAAAAVNAGAANVNKRDTFNAVGVLMVFTLLFSAAMSLLTKAARHELFAASAAYCAILVVFIGNFTGPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZZ0</accession>
    <name>R0IZZ0_EXST2</name>
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    <gene>
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    <organism evidence="11 12">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022195.1">
        <property type="nucleotide sequence ID" value="XM_008024004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IZZ0"/>
    <dbReference type="STRING" id="671987.R0IZZ0"/>
    <dbReference type="GeneID" id="19400084"/>
    <dbReference type="eggNOG" id="KOG3460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_5_1_1"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA90320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="96" mass="10911" checksum="ABD2558DE9B7FF1C" modified="2013-06-26" version="1">MDEKEETNEPLDLVRLCIDEVVIVKLRGDRELKGRLHAYDSHCNLVLGDVEETVFIAEEDEDDQEPRVRTVKKQSEMLFVRGDSVVLIAPAEGTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0R8</accession>
    <name>R0J0R8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_167258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022230.1">
        <property type="nucleotide sequence ID" value="XM_008024039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0R8"/>
    <dbReference type="STRING" id="671987.R0J0R8"/>
    <dbReference type="GeneID" id="19400100"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035338_0_0_1"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000404">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="333" mass="36926" checksum="BFB3D71BC640D51C" modified="2013-06-26" version="1">METSRSKETARVPPPIVTSAPPVAMPSPPPSQSGHAGDAKASMDMVDNNTPPFSPSSQTPVLQQEQEEFEGTLDINNDIPTEQDLSQVADMLVLDADGQSRPFKELYQAPHVASRQLIIFIRHFFCGNCQEYLRTLASSITPDDLLALPTPTFITVIGCGRPELIPMYTETTGCPFPIYADPTRKLYDHLGMTRTLNLGAKPQYMQTNVLINSVQSIFQGLSTGRKALKGGDFKQVGGEFLFENGECTWAHRMKTTRGHAEVSEIRNLIGLDSTKPPMRRKWSHEVKGPDKNKRRTLSWGRLRSKSKGGKDVSTDRDSSKQTTPDRILEEQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1W8</accession>
    <name>R0J1W8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_45189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Han J."/>
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                <person name="Wang R."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="580" mass="63468" checksum="FD956F651AABEB0C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJG1</accession>
    <name>R0JJG1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_165942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030929.1">
        <property type="nucleotide sequence ID" value="XM_008032738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JJG1"/>
    <dbReference type="STRING" id="671987.R0JJG1"/>
    <dbReference type="GeneID" id="19399637"/>
    <dbReference type="eggNOG" id="ENOG502SKYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_2_2_1"/>
    <dbReference type="OrthoDB" id="2932980at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="323" mass="35010" checksum="12EF8B7CFB8AEF59" modified="2013-06-26" version="1">MSAGYFPKREKVGLEDLFRGLVTACHILEHNGVVDAYGHISVRSPDNPATFWMPCNMPPALVSSPDHLVEYKVDGAEAVEKDAKPGYLERYIHSEIYKRFPAINSVMHSHASDVLPYCISGVPFKATIHMAGFLGTKVPVWNAANSYPSGAKHDLLVRDTTLGASLAASLKPATSTGFIYSKVRSALPAQLGGGASAEPKLEPDHAVVLLQNHGFVTVAHGIEEAVYQAIYTREAAKAQTAAMTLLNAHTGYALEGKVDTEAGGKIKSGHAKIEGGSLNYLTDKECHDAWESMSNTMTRAWALWCRQVEVNPLYKNECPEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLX9</accession>
    <name>R0JLX9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkaline ceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_34974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030134.1">
        <property type="nucleotide sequence ID" value="XM_008031943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JLX9"/>
    <dbReference type="STRING" id="671987.R0JLX9"/>
    <dbReference type="GeneID" id="19403968"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063293_2_0_1"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37950" checksum="73DF18CB048171F1" modified="2013-06-26" version="1">MATLLSHLPSIPYPPEQDGWFSPVTSTLDWCEEAANSSKNYVVTHYVAELVNTFTNLLFMYLAAKGIRNCLKNGHDTVFLVAFVGYLIVGTGSFWFHASLKYPMQLVDELSMIYTTCLMNFATFSYGKSRLYATMLGVGLMSLAVFITLYYHYLQDPTFHQNAYAALTAIVLFRAVYVMEINIRPRFRTREREAANPRLHGGAKGARQKEDQRDQEIISTMWTMIAFGLSIFVGGFAIWNLDNVYCSKLIRWRREVGMPWGFVLEGHGWWHLMTGVGAYFYIVWGIWLRHCLNYRQDEYELRWRNFWTMPEVVRRQDAGANGPAKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0JN60</accession>
    <name>R0JN60_EXST2</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">SETTUDRAFT_34169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1907989_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MgtE N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="133" mass="15973" checksum="77941FF2F7F73812" modified="2013-06-26" version="1">MNTILLILRRLQLEVDRVSTLDVPAFRAYIGDIEPHNLARLWRTIDDSRFRRKLSEDIDVSIVSNALEMLPYELKAELLKYMSNRQRLRVVRTWSPEKQLDELNRLENWQDMEDGNWENRIADTRVMTEHLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JQ24</accession>
    <name>R0JQ24_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_155837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029039.1">
        <property type="nucleotide sequence ID" value="XM_008030848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQ24"/>
    <dbReference type="STRING" id="671987.R0JQ24"/>
    <dbReference type="GeneID" id="19397563"/>
    <dbReference type="eggNOG" id="KOG2464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022500_0_0_1"/>
    <dbReference type="OrthoDB" id="21018at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="531"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="560"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA83283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="717" mass="80130" checksum="C3974236E0F7AC8E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JQV5</accession>
    <name>R0JQV5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_22226</name>
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    <organism evidence="4 5">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028749.1">
        <property type="nucleotide sequence ID" value="XM_008030558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQV5"/>
    <dbReference type="STRING" id="671987.R0JQV5"/>
    <dbReference type="GeneID" id="19402519"/>
    <dbReference type="eggNOG" id="ENOG502SQ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021599_6_0_1"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="502" mass="56578" checksum="F990779110CF506D" modified="2013-06-26" version="1">MPKRSTGCFECRKRKVRCDEAKPECNTCLKRGTKCPGYRPTQAFILHEFDAKGDKPALIKEDENRYRFANSQQPVQPQSQAIDRRDSTIHGPGEIHIPKQVSSVAADRIQHVGTFISLYLPKTEGPALPPPSALMLGLPSMPANSEVLMAAIDALSAAQLAVNNRDHPLIHRSRSLYGTALTQMMRAIQNTKVALKDETLLSTYLLSLFEVFVGVTSGQGFFCHVQGLLHLLKQRGPESFQSRLSMQIFHAIRYNSLSIGYLMRKASMLDTPEWLAVTARAARIDPYVALLDIVMGIPQLLERTDDLAKPGSPPEEIDKLLNDCDQTAGRAFDWLNNFERHGPRYNKVDVASIDGFMDICADRVFDPVFQFHYFAAGICYLIYWMSMLIMQGNTFKLLRQHRQLDPKQLMAWGRQLENFADSICRSVPYHCRPLTGYSGRFGSLTPLMVARKYYEMRGATAQATWCLNVYMGARVPELYDAPPPVNPLAEMGVQVKNNPRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JRI2</accession>
    <name>R0JRI2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_118499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028234.1">
        <property type="nucleotide sequence ID" value="XM_008030043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JRI2"/>
    <dbReference type="STRING" id="671987.R0JRI2"/>
    <dbReference type="GeneID" id="19395751"/>
    <dbReference type="eggNOG" id="ENOG502SC4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029214_2_0_1"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="2">
        <location>
            <begin position="398"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="507" mass="54696" checksum="F1AEC2671E9A696A" modified="2013-06-26" version="1">MTLDELNALPTPESNGDSKAQGRKARGSAAQSKSSAAATKAPAKGRPVARRTSGTSAVVMKKKAAGAKKASAKGGRKAQAESGDANGSETEEVDGFDDDEPAPPAKSTKRGRPAKKAQEEETQEEEAAPPPAKRGRKPAAKEAVEKKETKAKPTAKSRGTKRALEPEPEPEQMTIPETQPEPDADAMDISESIEMEEIPESMPPPVRPSARRAHAQPNSRARRTSAGVRRTGSVSDSERDPVMRRKVGDLTKKLDAMTAKYEALQEAASSGKETNFDLLKKRTDQTVKDQDAVIKSLRQQVSDLQSRTGDLSSLKKDVAAAAKESARLAAENKRLHDALTTAQNENKTLSSKLAAARASSAQPETKTVPGSAVKPRTTGVVLPGTAEAVKEATLARQKVDLYSDLTNLVVLSVKKSDDGDDVYDCLQTGRGRTLHFHLTVTADSASPEDTEFIYQPLLDEQRDRELLDILPDYLTEEICFPSAQAVKFYCKVLDSMNKKVVLEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JTZ6</accession>
    <name>R0JTZ6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_44830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
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        <source>
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</entry>
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    <accession>R0JWQ1</accession>
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        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_143585</name>
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    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="65093" checksum="FE3D85E3958D824D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWW6</accession>
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        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_143720</name>
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    <organism evidence="11 12">
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
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        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
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        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
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    </comment>
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        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:protein targeting to vacuole"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
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        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="10">
        <location>
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            <end position="639"/>
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        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA80747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117226" checksum="A07A54F9A5409E0D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXT2</accession>
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        <name evidence="2" type="ORF">SETTUDRAFT_169634</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908648">
        <property type="protein sequence ID" value="EOA85728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="InterPro" id="IPR025337">
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="113" mass="12560" checksum="41AA8AE3BB9FE23F" modified="2013-06-26" version="1">MPSEMTAPTQSLFAVPDHIDEAAKREPDAIWALIPRSNTSLKLGCYQYKYAELARAVDDLEWWIEKEVGIPGHIGQTIGYMGVNDLNYLLVHAATLKVGYVPLFVSPRNSIDG</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13417" checksum="68833E4D6E07BC6E" modified="2013-06-26" version="1">MYESALEGYKNTFGPEQLDTLRTMDDFAGVLVNQRNYKEAEALFRQLLAGHEKALGNEHPDTLRCAQNLTQILKRMLRNRNKDSDEKDAGQEDVKTMKRGREVTDEAYEVPKKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZ68</accession>
    <name>R0JZ68_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_151198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026168.1">
        <property type="nucleotide sequence ID" value="XM_008027977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZ68"/>
    <dbReference type="STRING" id="671987.R0JZ68"/>
    <dbReference type="GeneID" id="19397108"/>
    <dbReference type="eggNOG" id="ENOG502QT3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF26">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="201"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA86163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="338" mass="36824" checksum="F17EF1108C61E05F" modified="2013-06-26" version="1">MSVNVLIVGAGAIGAFYASRLALVSGTSVSVICRSNYKAVKANGFQVTSPQYGDYTFTPANTFANPEEAKKSAIEWDYVVVSTKALPDVSDDSAILEGLVSDKTAIVLIQNGMGVEDPYSKRFPKAAICSAVTIATCAQPEPGHIKHNRWTRINSGPYLPHLDTGAPKDSDPSIIEKNDAFIALLKEGGIKDAEAYSHAKLQLVRWHKIAINASMNPTSVLTLGSPNSLMAQDPELQRHLMGVMTEILETAPKVLGQPMPKEFATPEQIIKSTLKNTSGSKPSMAIDWEGGKKMEIEVILGNPLRIARERGFEMPRLQSLYAMVRMAQEIRDQKKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZA5</accession>
    <name>R0JZA5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_177413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-222 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026201.1">
        <property type="nucleotide sequence ID" value="XM_008028010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZA5"/>
    <dbReference type="STRING" id="671987.R0JZA5"/>
    <dbReference type="GeneID" id="19401533"/>
    <dbReference type="eggNOG" id="KOG2960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053727_0_0_1"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        <ligand>
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            <end position="112"/>
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        <ligand>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Secreted protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="100" mass="10818" checksum="CDCC03D5BBA571D4" modified="2013-06-26" version="1">MAPPRRGSVLTCIRIGATTAAAATAAAAGYGYPDVAATKEKHQPEGCSRLRHSSKTQTLPAWRRRLLGSRTERRSRGLRQVCCTPLLARRPDEGLFGLST</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032139.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19395869"/>
    <dbReference type="eggNOG" id="ENOG502RIAY">
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    </dbReference>
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    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA81977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="385" mass="42538" checksum="A1050F9AAE408411" modified="2013-06-26" version="1">MLASLATAVPLQRLALHPRDMDKIQTPNTAGETASDRTIYTITSLVFIMILSLLLGSRFARLRRSIVLKRSLMSLLVVFLYILVFIFIIVSDTLVSGQGLHTESLCMAGTWVCLCFYTLIKATIYTFFVERIHVVRAPFVNRRKDKIYLACMAMIALMYSCVAINAGINHVVELKDSDGRCYFGIRAVVAVPFVVVNFFTDAALTAVFVYLLRPVLQKQGGSAYSCMIVRRSGKADGPTHGGEDTPMRKNIRNLLWKSIIGSLLIEISSAANMVQIIATKGDELGMICMTICLVDVFWDVLVIHWLLFGLSGSAPDRDPMPSKATFSEGPSTLAPGRAQSELKSQLDMNRFCQDLGDLRIGGSDMRCNESCDSVSGLILPERAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0Q7</accession>
    <name>R0K0Q7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_141924</name>
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    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
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        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
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            <topology evidence="9">Peripheral membrane protein</topology>
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        </subcellularLocation>
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        <source>
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        <source>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <end position="258"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
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        <location>
            <begin position="289"/>
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            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="491" mass="54548" checksum="30842AA43A2AAABB" modified="2013-06-26" version="1">MLLQPDPTLAEVPGFTKEQLDALARSVELRRHQLETDIASYIRCKQDELRNYGHQLIDQYRSTQCPQQLASDRKSPASNADDAVKAPEPDDRIKQKKHTKVHKREQELYGLVTPVFLPLLDARDSSPDKRRTPKPPTPYGANDAADSPPARPSRDAEQTKARKQRKDNKDLESPAPGALAKDKQSGEAPKKMKRSTMKKSALRHKDKPRTPRKRVSLVIDGQTVHPSDTVDEPLLTSPSSETTSASNSIASLDDMIDPRLTTSDPPLFLEHRNDIHHSLPLPMANAIQSASKAYSESHTPTPVSIATDHSPPLHSPRSPSIPSKPTQPPMRTFLDPSPIQQSHSIPETAGPDPIYSISPVTTTELESDSLAEEEQDFDTYVGGLHGSGVADVDQAGSYGYPSSLGASYMESYMQNRPLRVRMEAATKAGLSEAEKRRLLEERVEEEEDHVHDDVDNDEDDSDDLSDIDMDHTRKKSKDLGEDHFMGDMDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1B5</accession>
    <name>R0K1B5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_115571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025493.1">
        <property type="nucleotide sequence ID" value="XM_008027302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1B5"/>
    <dbReference type="STRING" id="671987.R0K1B5"/>
    <dbReference type="GeneID" id="19395657"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA86948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="468" mass="51121" checksum="E5B07D71C82E8FCA" modified="2013-06-26" version="1">MSLEKITTISPITNKPLLTRNGLSEADVESIPETASAAFASYRQTPLAERKAIVKKALKILSDRQDVLGKEITEQMGRPIAYTAKEVATAVMRGEYLLKISDETLKDTDGEPEKGFKRYIKKVPLGPVLILFPWNYPYLTLINSLVPALLAGNSVILKPSPQTPTSAEQIQQIFKEAGLPDGVLQIFHSGSSIQIEAIARSPKIQLVCFTGSVANGLAIQQAANDRVPLRIGLELGGKDPAYVRSDVDVKWAAEELVDGAIFNSGQSCCSVERIYVDEKIHDEFVSAVQEVLSGYKLGDPFDKSTHVGPVVSKRSAEAIQAHIKDALDKGARNATPENDTFKNPPADGNYVAPTLLTNVTHEMAVMTEETFGPVIPVMKVKSDAEAIKLMNDSQFGLTASIWTKDVSKGHELADDVEAGTVFVNRCDYPAPDLAWVGWKDSGRGQTLSKFGFDQFVKLKSYHVKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1C0</accession>
    <name>R0K1C0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_96879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030481.1">
        <property type="nucleotide sequence ID" value="XM_008032290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1C0"/>
    <dbReference type="STRING" id="671987.R0K1C0"/>
    <dbReference type="GeneID" id="19406270"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="74"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="512" mass="54163" checksum="BAB0C8C9B92CE569" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K275</accession>
    <name>R0K275_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_164164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028226.1">
        <property type="nucleotide sequence ID" value="XM_008030035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K275"/>
    <dbReference type="STRING" id="671987.R0K275"/>
    <dbReference type="GeneID" id="19399018"/>
    <dbReference type="eggNOG" id="ENOG502RXUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_0_1_1"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA83714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="307" mass="34871" checksum="559195244643CFFF" modified="2013-06-26" version="1">MPYSHHSHSGQFCGHATNTLEEVIQTAIAKRFQTFCLTEHMPRPLEDFYPNEAEKYTPQSLVDLFENFLAEAHRLRDVYAGQIQLLIGFETEYIRPSTLGLIRGILDKHTFDFFMGSVHHVHTVPIDYDRPTYEQAREKAGGTDERLFEDYFDLQYEMLQELRPLVVGHLDLIRLLSDHRDDGFKDMGGVWQRIQRNLEFIASYGGLLELNSAGLRKGLAEPYPCLPICQMFLRMGGGFVMSDDSHGVDQVGTNYGRLLAFVKKAGIDRIYYVDGAGEPKDSRFPNAGVSSIALADLEQLPFWAAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2C5</accession>
    <name>R0K2C5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_163271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025738.1">
        <property type="nucleotide sequence ID" value="XM_008027547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2C5"/>
    <dbReference type="SMR" id="R0K2C5"/>
    <dbReference type="GeneID" id="19398716"/>
    <dbReference type="eggNOG" id="ENOG502SA4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111658_1_0_1"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="PHI-base" id="PHI:123376"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344195" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA87293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="135" mass="14344" checksum="AC116C3919F699EE" modified="2013-06-26" version="1">MKFLTSILLLVAPIALALPTSDATLEVRQSCYVQCGNTCYSSNQIQAALNAGFNYYSNDDQAGSSTYPHRYNNYEGFDFPVSGPYQEFPLKTSGVYSGGSPGADRVIFNTQGQLAGEITHTGASGNNFVGCSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2H2</accession>
    <name>R0K2H2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_165069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029674.1">
        <property type="nucleotide sequence ID" value="XM_008031483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2H2"/>
    <dbReference type="GeneID" id="19399351"/>
    <dbReference type="eggNOG" id="ENOG502SCEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133919_0_0_1"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="2">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7871" evidence="2">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="76" mass="7850" checksum="1EB2FE92EF76EB4D" modified="2013-06-26" version="1">MVCCGRNNGACVCAQEATCSCGKQPALQCTCEKAATENKLPESTCACGKRAEDACNCSRSQNSGSSSLETDFTTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0K349</accession>
    <name>R0K349_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_156478</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029812.1">
        <property type="nucleotide sequence ID" value="XM_008031621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K349"/>
    <dbReference type="STRING" id="671987.R0K349"/>
    <dbReference type="GeneID" id="19397628"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005898_0_0_1"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="686"/>
            <end position="861"/>
        </location>
    </feature>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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                <person name="Han J."/>
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                <person name="Bushley K.E."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023413.1">
        <property type="nucleotide sequence ID" value="XM_008025222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6W1"/>
    <dbReference type="STRING" id="671987.R0K6W1"/>
    <dbReference type="GeneID" id="19395198"/>
    <dbReference type="eggNOG" id="ENOG502SIXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076412_0_0_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="314" mass="34508" checksum="57A6715F41452E65" modified="2013-06-26" version="1">MPASSPLKVGVIGPAGFGGSYLAVELLNRGHTVIGISRNPSKLGKHERYIPRSVDIDNAPIEEIAETYKGIDVLVCEFGPHTAGVGALLYMPFLEAVRKIILAYKLQPARYFLFVGGAGSLHIPGTTLPCVDHPDFFLAYRRTISTSLAHIAYMEERLGILGTSLRRYRTARLASPKSAEDAAVIAEYEKQIRQKDTASDFIKAGRTAYMFFEDRTSFEWSFVSPPALYRPGKRVGKYEISVDEMVLVGEQKEGDDMFEGRLTGISVADMAIAIADEVEARNLVWKHWSAWGDISEDVPAPAYASLESVEGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0K728</accession>
    <name>R0K728_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_168048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023469.1">
        <property type="nucleotide sequence ID" value="XM_008025278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K728"/>
    <dbReference type="STRING" id="671987.R0K728"/>
    <dbReference type="GeneID" id="19400405"/>
    <dbReference type="eggNOG" id="KOG3065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020823_2_0_1"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="361"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA88803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="424" mass="45441" checksum="43A6740B7ECF475B" modified="2013-06-26" version="1">MGLFGKKKDKGAEAEDSNRSALFGNRKGKESPAAQNPYAAPPANDPYAQPPPSYSNSGPDNSFRQEKTPAVTGPGQSYGQQSGGYGAQGGSYGAQSGYGNDRYGGGGATQRPGGYGGLGRTPSNDTMATDAGRNELFGNAAQRQQARPQQESGGYGQSGAYGDSQSGAYGGGASGGYGSTPGGYGTYEDRQLTAEEQEEEDIKATKQEIKFIKQQDVSSTRNALRLAEQALETGRGTLSTMAAQGERIHNTERNLDLAAIQSDRASGQTKELARINASMFSIVPNPFTGNSKREKEMQRAMDQHARDRETREATNKAAWESNARANAAQRGLQTAGAGIGGNKASLAQRSKYQMEPDSEDDEMENEIENNLDQLHIAAKSLNHLGRAMGEEADRQNEHITRITGKTDNVDDKIARNRLKLDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7N4</accession>
    <name>R0K7N4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_172761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028643.1">
        <property type="nucleotide sequence ID" value="XM_008030452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7N4"/>
    <dbReference type="STRING" id="671987.R0K7N4"/>
    <dbReference type="GeneID" id="19401207"/>
    <dbReference type="eggNOG" id="ENOG502S3DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_9_0_1"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1907985_0_0_1"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="133" mass="15565" checksum="1EFE9E581A8BCC9D" modified="2013-06-26" version="1">MLPSPSIADREELTLNPEHELKGYILAHAFCSATNRLWVATLDEQKDESLYHLYRIEPNRDDYHNFTTKRDYVHKITSDEIYLQRRSFMLDTVQEQLNLEKEQIPRFLAISRTGDVALENQVAELTSGEALRQ</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <end position="16"/>
        </location>
    </feature>
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        <location>
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            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
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            <end position="547"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA89558.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="552" mass="59352" checksum="3D57178880C280DA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA46</accession>
    <name>R0KA46_EXST2</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="388" mass="43574" checksum="270931DC2A5049AB" modified="2013-06-26" version="1">MARNKKDAQPTATSTQMPTRPMGQLVQLDALIESNGVTFKFDQLPPVDDFVFGAVGTLHLKDKNTHAEKLFLGQNATRRTWALLKYWSVSAHKGSEVIFYNEMSNGLSLAVKELSEMALMYPFKVFKEKNLVQSIRHLSHFVQYIYLYTGKVSKVFPVSLLTAEEVLLSAVGTIYTAYEKKGGVEVIPDCHGPGPFDDVSLDDDQIPLLDKDAIRKAALNSAEQVIESSPDPELPDIYAPGPSTEYKGKGKQKETDPIDSDDDGDAQSVISKGRHDMALGRSERGLTPLTDVLSGIKRKADGEEPYHQYRRLKNRKQKELQREKELQKQLKEIQARKPTYDREMQMLLDQQSKDELVRWALANSVEGSEENDEEEENNGQPNASLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="COMT_C"/>
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        <property type="entry name" value="COMT_dimerisation"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
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        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
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            <end position="383"/>
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    </feature>
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        <location>
            <position position="314"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA85722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44059" checksum="B67AC2EFF4FE4AD3" modified="2013-06-26" version="1">MTAPPSTLLSLVRTITHLGDAFDAANGFAHQETRCQLVDAAEKLAIAARYPDENVFFAVTRTTQNACIRIACALNIFAVVPWSNSAAESPPASISVADIASAVGADGVVVARIMRALASCHIFTETGQDAYAHNHLSRAFLVPESLSMFSEIYDMAGKAAFALPDFLAKTQYKNPDDYNHSAFHLGAHTDLGFWEYLQADESKFQAFNNGMRSQATVKEFDSSYPFEAELNAVPLAQDEVVLVDVGGGRGHALERIKQRFPGLKGKLVLQDQAPVIKDAVAGGLSPAIEAQAASFFEPNPVKNARAYFFRRVLHDWSDAVCQSILQNTAVSMGPDSRVLIAEYEVPATGAPAKLTMQDVNMMGIGGCERTEDMWAKLLDSAGLKLEKMWRTPGSNFVVVEGRLHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCA6</accession>
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    <gene>
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    <organism evidence="8 9">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022356.1">
        <property type="nucleotide sequence ID" value="XM_008024165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCA6"/>
    <dbReference type="STRING" id="671987.R0KCA6"/>
    <dbReference type="GeneID" id="19394932"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="18"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA90538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="352" mass="37435" checksum="7B87E27DCD30C819" modified="2013-06-26" version="1">MSTSIPTTQTAGWIQDPGPDCVLQIRNDVPVQTPAAGEVLVKMEYSGICHSDCHNLAWPGKYTEVPGHEGVGTVVSLGPNVSSDLLGKRVGIKWLWNACKQCSSCKKGKENHCGKQKNTGRNTWGTLQQYIVADADFLTHIPEGLKSEIAAPLLCAGLSLTGAVSKLEPDLQKGDSVVIVGAGGGLGHIGVQIASIKGYNVIAVDSGAEKEKLSKEMGATTFIDYAKQDVVKAVKDLTDGEGAHGVICVSGSEQAYTQAPSLCRTSGVFVCVGLPRDTFMFPMSPIHISNKKGLTIRGSSTGSAKQMEELLQMAVEGKITPKVEVYDFADSPKILQELKRNEVTGRKVVRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCM4</accession>
    <name>R0KCM4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_153857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008027420.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SA8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3642840at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="628"/>
        </location>
    </feature>
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        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA87109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="947" mass="107130" checksum="865FE76EC28EAB74" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCR5</accession>
    <name>R0KCR5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_135723</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025624.1">
        <property type="nucleotide sequence ID" value="XM_008027433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCR5"/>
    <dbReference type="STRING" id="671987.R0KCR5"/>
    <dbReference type="GeneID" id="19396328"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="58"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA87139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="487" mass="53282" checksum="97C657556D74E6F4" modified="2013-06-26" version="1">MCPPTEETPAANGHSNGTNGTPVSKEGFTGVHTKQNPHPSHRSPYQPVGDFLSNVGRFKIIESTLREGEQFANAYFDLEAKIKIAKALDNFGVDYIEVTSPAASEQSRRDCEALCKLGLKAKILTHVRCHMDDARIAVETGVDGLDVVIGTSAYLREHSHGKDMTYIKNTALEVIEFVKSKGKEIRFSSEDSFRSDLVDLLSIYSAVDKVGVDRVGIADTVGCASPRQVYDLVRTLRGVVSCDIETHFHNDSGCAIANAFCALEAGATHIDTSVLGIGERNGITPLGGLMARMIVADREYVTSKYNIKALKEVEDLVADLVEVNIPFNNYITGFCAFTHKAGIHAKAILNNPSTYEIINPQDFGMSRYVHFASRLTGWNAIKSRAEQLGLKMTDAQYKECTAKIKAIADIRKIALDDTDSIIRTYHNNLHTTEEVPLLPGMTEEEKAKFAQAEAELSGVNEKRELDATADAQAEVPVAKKNKVVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KD25</accession>
    <name>R0KD25_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haloacid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_166696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021548.1">
        <property type="nucleotide sequence ID" value="XM_008023357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KD25"/>
    <dbReference type="GeneID" id="19399903"/>
    <dbReference type="eggNOG" id="ENOG502S0RM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_2_1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22300" checksum="C711842C6F229564" modified="2013-06-26" version="1">MQVMHKIEARVEREHGQLKYSQVLAMVLPELCESLGLEKPSNEECTRFGASIGDWPGFPDIPSALERLSKFYKLVVLSNVDHDSFKRGNANGLKGFKFDAVYTAQDIGSYKPDPRNFEYMLSHVEEEFGVEKHEVLQTAQSQYHDHHPAKDMGIKSSWIYRPGAVMGNRDDPVYNWRFDTLAEMADAVEKEFAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KE14</accession>
    <name>R0KE14_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_28413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025897.1">
        <property type="nucleotide sequence ID" value="XM_008027706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KE14"/>
    <dbReference type="STRING" id="671987.R0KE14"/>
    <dbReference type="GeneID" id="19403246"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="261" mass="29884" checksum="4049A4B37BC00498" modified="2013-06-26" version="1">MPQNEYIERFTKQHGKRFDHDERKRKREAREGHNASKKAQNLRGLRAKQYAEKRRKEKIQMKQKIRAHEERNVKSNEAPEPATEALPSYLLDRSSEKNAKALSSAIKQKRNEKAARFSVPLPKVKGISEEEMFSVVKTGKKTKKKSWKRMITKPTFVGPGFTRRPVKYERFIRPMGLRYKKANVTHPELNVTVQLPIISVKKNPQQPLYTQLGVLTKGTIIEVNVSELGLVTAGGKVVWGRYAQVTNNPENDGCLNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEQ5</accession>
    <name>R0KEQ5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_87121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020505.1">
        <property type="nucleotide sequence ID" value="XM_008022314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEQ5"/>
    <dbReference type="STRING" id="671987.R0KEQ5"/>
    <dbReference type="GeneID" id="19405627"/>
    <dbReference type="eggNOG" id="ENOG502S7RA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043191_0_0_1"/>
    <dbReference type="OrthoDB" id="5394557at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="493" mass="53282" checksum="DEAFE768E70EBCEB" modified="2013-06-26" version="1">MEYENPRTCLSQNIPYPNCGYGERNAPLTLAHNTRENPRSYPVGGPVGGMHNRGMMAREDSVMETGPARRRIAVACARCRKRKIRCSGDPGNGSGCINCRQASVDPMSCQFHRVGSDSYDKVIGNFTMVPSLSSMANAQHMVPLYQTGGSTAVYPRSVSVPSFSQYQQTDNRSVCNPVWAAPYSEDMSPVDTYNFDQPPPYASIYGSQHRGGDLAARPLQYGGTCFDHESLNASHYTTSNGRLNPSDLSPLDTSMASLQLSVSERLQPRQPHPSESSGPRRELPVPQPNLSQSSRNVVDQMQDARLLRYAPPIGSIMDNRVSFSKPLIPWDLDGSKQTNAPVVASVSAHQAQLSDSMESPTSCISTTTSAPNNTATTSTSSQLDLSFSTAGPLDGMSAPTAATPYSCVRASRHMAPADSPTNLYGFGNTRPIKRNASNDDLANECSLVSGHRYSLNPSPPQNSQGSRKTHRDSCKGRNAQLQHAATGNLNACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0KER0</accession>
    <name>R0KER0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_40464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020268.1">
        <property type="nucleotide sequence ID" value="XM_008022077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KER0"/>
    <dbReference type="GeneID" id="19404626"/>
    <dbReference type="eggNOG" id="ENOG502RMEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052361_0_1_1"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07257">
        <property type="entry name" value="THT_oxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="59"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="205"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="375" mass="42504" checksum="F5560F2EACE31B4E" modified="2013-06-26" version="1">MAFDELNDKITPANPSREVSPNRGSSVHQSAAIPKPCKPLRQWQQENNIDRSAQIKLTKLVHMRYQHPDMDEITQFLRDFGMSVAQKSEGKKWFKGYGDDQYVYYAQQGEKKFLGGCFEVESYAELEKASKVPGASPIQELTDAPGGGFMVTLHDPEGFPINLIHGQTKREPGPFPEILTTNYEHEKPRVARFQRFKPGPAAVHKLGHYGLCVQNFQEEMQWYTRTFNIVPTDFLYVPTNTSSDDTSSPSSPQQKDVAIFAHLDLGPGYTDHHTIFLSSNPTSHVHHCSFEVHDFDTQNLGHEWLAQKGYKSVWGVGRHILGSQLFDYWWDTTGNMIEHYADGDLVNEDTPVGWGEAGDESLAVWGPEVPMWFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KG05</accession>
    <name>R0KG05_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_133600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020842.1">
        <property type="nucleotide sequence ID" value="XM_008022651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KG05"/>
    <dbReference type="STRING" id="671987.R0KG05"/>
    <dbReference type="GeneID" id="19396205"/>
    <dbReference type="eggNOG" id="KOG4042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085418_2_1_1"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="228" mass="24397" checksum="74F107584B17F3AA" modified="2013-06-26" version="1">MSAQPTSSRPTSDRRSFTAPKRTSLLPKPSSIVLDSSVLIAQHAQITGIHPITIGPNTVLHPHSKLSSALAPVVLDEGCVIFERAKIGVGTAAELDAESRRTSIAPARSSAHIRNSMRSEGTVLGRNVVVESGAVVEAAEVGEGTVIEVGAVIGRGSIIGKYCTITASSFLPANSRLPDYTVVFSGSQQRIDRTLQLRPEILRAKMTVHAKQLDMFKRLIPNNIAKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KHV6</accession>
    <name>R0KHV6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_169025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024824.1">
        <property type="nucleotide sequence ID" value="XM_008026633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KHV6"/>
    <dbReference type="STRING" id="671987.R0KHV6"/>
    <dbReference type="GeneID" id="19400762"/>
    <dbReference type="eggNOG" id="ENOG502QPST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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            <begin position="23"/>
            <end position="554"/>
        </location>
    </feature>
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        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="11">
        <location>
            <begin position="394"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA87607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="554" mass="58938" checksum="843A2AB685CEF3C6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KIV7</accession>
    <name>R0KIV7_EXST2</name>
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        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_37632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022901.1">
        <property type="nucleotide sequence ID" value="XM_008024710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KIV7"/>
    <dbReference type="STRING" id="671987.R0KIV7"/>
    <dbReference type="GeneID" id="19404278"/>
    <dbReference type="eggNOG" id="ENOG502QSEW">
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    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="212"/>
        </location>
    </feature>
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        <location>
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            <end position="820"/>
        </location>
    </feature>
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        <location>
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            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="684"/>
        </location>
    </feature>
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        <location>
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            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="820" mass="88643" checksum="0DF30C027A2758D1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KK00</accession>
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        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_167949</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023256.1">
        <property type="nucleotide sequence ID" value="XM_008025065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KK00"/>
    <dbReference type="STRING" id="671987.R0KK00"/>
    <dbReference type="GeneID" id="19400369"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036369_3_0_1"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA89494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="332" mass="38524" checksum="88B673CCAE709890" modified="2013-06-26" version="1">MRRGVTIFLLVTAVVLGFAVHSVWTLLGLLVATGREDAILRGELPAPNSSAINHAPQLIPKIIHQTYINESIPAHWKAPQQSCIDLHPDYEYKLWTDKKAREFIAAEYPWFLETFDGYPYPIQRADSIRYFVLHHFGGIYIDLDDGCNRSLDPLLAYPAWVRRTVPTGISNDAMGAIPRHPFFLKAIDSLTDYNRRWPLPYITVMASTGPLFLSLVWRHYNNAGPVDEERVRILFPEEYNNHSWSFFTHHLGNSWHRTDVKVIFWLARHWLLVTILGFIAGFTILGLLYKFFVMNKRSSGPGSPKIRFLNQRMPFYRRISQKSFELDDRHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKP8</accession>
    <name>R0KKP8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_167519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022655.1">
        <property type="nucleotide sequence ID" value="XM_008024464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKP8"/>
    <dbReference type="STRING" id="671987.R0KKP8"/>
    <dbReference type="GeneID" id="19400206"/>
    <dbReference type="eggNOG" id="ENOG502S8N8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054609_1_0_1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000013">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA89699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="303" mass="34003" checksum="4F10DB44A2AC9E8C" modified="2013-06-26" version="1">MSPRRSDSMEAQDNIRKRVCKACDRCRLKKSKCDGASPCSRCKADNAICVFGERKKSQDKVYPKGYVEMLEQQQGQLVAGLRELYSRLQRGESWPGQPLQETAAGHPLTHDILERLDLLHASTDSPNHYDGFEEDCSRMQQRLIEGGAPFTRRRASVSSESDHGHVSSNSSYNGTPTTRTFAYESPFARNNAPPTPPMNSPFPRQSQVVEPVKQEPVMASPPFMPTSVMDPSALSRTPWINDAIIMDDTIDFKPMYAFDSYGAYDQNMMVDTAAITPNDPMMPDWNTHNELDFNNFIQNPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKX4</accession>
    <name>R0KKX4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_107517</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023978.1">
        <property type="nucleotide sequence ID" value="XM_008025787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKX4"/>
    <dbReference type="STRING" id="671987.R0KKX4"/>
    <dbReference type="GeneID" id="19395232"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="119"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="219"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA88597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="316" mass="33965" checksum="78F8F7FC62F2837C" modified="2013-06-26" version="1">MSGKQQDKSVMGMPGFMVDFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMLKSGRLDRKYNGIVECFSRTAKNEGVLSLWRGNTANVIRYFPTQALNFAFRDTYKSMFAYKKERDGYAKWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKKGGERQFNGLVDVYKKTLASDGIAGLYRGFMPSVAGIVVYRGLYFGMYDSIKPVLLTGSLEGNFLASFALGWAVTTGAGIASYPLDTIRRRMMMTSGEAVKYKGTMDAARQIVAAEGVSSLFKGAGANILRGVAGAGVLSIYDQAQLLLFGKKFKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KN52</accession>
    <name>R0KN52_EXST2</name>
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        <recommendedName>
            <fullName evidence="10">Sucrose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_147756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023150.1">
        <property type="nucleotide sequence ID" value="XM_008024959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KN52"/>
    <dbReference type="GeneID" id="19396929"/>
    <dbReference type="eggNOG" id="KOG0637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018303_0_0_1"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF76">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
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            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA89352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="57292" checksum="39C889D992B9B5B9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNY6</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">SETTUDRAFT_36297</name>
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    <organism evidence="2 3">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNY6"/>
    <dbReference type="STRING" id="671987.R0KNY6"/>
    <dbReference type="GeneID" id="19404111"/>
    <dbReference type="HOGENOM" id="CLU_1533499_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="175" mass="16768" checksum="A1AC6797415DF97F" modified="2013-06-26" version="1">MAWHGMHPASSEQHTDTYAGTQMSGLRICNVCMYHISSSGSSASASSSNGADVTSTVAVIVSSATSAAGSAASSVRSSMTSMASSAASEAASLTSSIMSDANSALSSLSSEASEIMASASSAISSATESAASAAESATGSGSEASGTATNSEGAAPRVTGLSFAAGAGMAAWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KP48</accession>
    <name>R0KP48_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_52159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Han J."/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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        <location>
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            <end position="180"/>
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        <location>
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            <end position="357"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
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        <location>
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            <end position="346"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="588"/>
        </location>
    </feature>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KWX6</accession>
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        <recommendedName>
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            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="10" type="ORF">SETTUDRAFT_162660</name>
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    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022900.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Glyco_hydro_27"/>
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    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
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        <property type="entry name" value="Melibiase_C"/>
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    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLHYDRLASE27"/>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354451" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="551"/>
        </location>
    </feature>
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        <location>
            <begin position="330"/>
            <end position="401"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF17801"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA92197.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5R1</accession>
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        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
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        <name evidence="12" type="ORF">SETTUDRAFT_182079</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
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        <property type="protein sequence ID" value="EOA80970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502RGMX">
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    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_98184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030289.1">
        <property type="nucleotide sequence ID" value="XM_008032098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8S8"/>
    <dbReference type="STRING" id="671987.R0I8S8"/>
    <dbReference type="GeneID" id="19406354"/>
    <dbReference type="eggNOG" id="ENOG502RZ3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038171_1_0_1"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="177"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="397" mass="44481" checksum="A215B888FFBF32A7" modified="2013-06-26" version="1">MAITDNLPKSDSPSLALVHPTEAEKHMQFTLNAAEWRGALKLPAYLRREAHLAQTDMTRNGGISYWILVDTSLPNNPLDPHSGTRLPLASCETYRKKALVWQDGVLKQVICHGIGSVFCANHLRKRGYAQRMMTELGNILETYQTDDGTECLFSVLYSDIGKKFYNSFGWEPFTSSHLSLSGTPSQNTSGLPTARPLYAQDLPDLCDIDVASVRRNLESRPKGSNTAVAIIPNLETIRWHHAREEFVGNELHGKMPEIKGAIVGTEKGKRVWCYWTRMWYNQDPTDTKGNTLHILRLVVEDAGWEGSSSHAHDHSHDAAIAALMAMAQREAEAWKMENVEMWAPTPTAVAAANRLDPSAKVVDRHVESIASLRWFPEHKGPVADKIDWLGNEKYAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBB7</accession>
    <name>R0IBB7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_96094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029727.1">
        <property type="nucleotide sequence ID" value="XM_008031536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IBB7"/>
    <dbReference type="GeneID" id="19406211"/>
    <dbReference type="HOGENOM" id="CLU_013929_2_0_1"/>
    <dbReference type="OrthoDB" id="4357141at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="152" mass="16953" checksum="7DBC6551FD7B4198" modified="2013-06-26" version="1" fragment="single">MLGSVKVLVSKDDLRDYRGAGVKRTQVTAIECISADGRSLLPLIIWPASTHRSNWTTFSTPGWHYGHSENGYNDSKISLEWLTRVFDPQTSGRANGKPRVLICDGFGTHETLEVLEFCFANNITMCRLPSHTSHKLQPCDVGVFGPLKTAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBS0</accession>
    <name>R0IBS0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">beta-glucosidase</fullName>
            <ecNumber evidence="5 14">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_156525</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5 14"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029855.1">
        <property type="nucleotide sequence ID" value="XM_008031664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IBS0"/>
    <dbReference type="STRING" id="671987.R0IBS0"/>
    <dbReference type="GeneID" id="19397633"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable beta-glucosidase"/>
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        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
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        <property type="entry name" value="Fn3-like"/>
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    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="687"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA82860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="766" mass="83406" checksum="D6822F44FBEA300B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBU4</accession>
    <name>R0IBU4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_34222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19403886"/>
    <dbReference type="HOGENOM" id="CLU_966973_0_0_1"/>
    <dbReference type="OrthoDB" id="3695542at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="288" mass="33658" checksum="D0FE2379DECAD300" modified="2013-06-26" version="1">MSTSLETIPDELKLEIFQYLPSRLNLDLTSRHLFWITPGDLVRRAKTPDSVAEAIRAIRYMILFSEERVSDGLNILFDKFLIRVSDYVIYFLQHGSFKEAKAMLQAWEQLPLQEHIPAEHLLKVLKQLDISLLRRSKMKISERQKTTLEIMKQQPCTSIMPKDFCLAPLNQIKEWIIRIIRDGTNRYEHLRKAKEALQFIKKIPAEAKVPKNFFLDVVKTGRDIILQAFREEQLRFGSLYVADGVARIIMLFNMIIPENYFLEIIKRGQDIICQAAEIPTRELTRGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IE63</accession>
    <name>R0IE63_EXST2</name>
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        <recommendedName>
            <fullName evidence="10">Indole-diterpene biosynthesis protein PaxU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_94446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA83436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029150.1">
        <property type="nucleotide sequence ID" value="XM_008030959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IE63"/>
    <dbReference type="GeneID" id="19406109"/>
    <dbReference type="eggNOG" id="KOG2521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036503_0_0_1"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA83436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31911" checksum="85102EE508498D39" modified="2013-06-26" version="1">MDPPTPPPGDAKPLLDFQKIGHNTYVWTSAAYLSKSPPETPLILLFSWNAAAAKHIAKYTIAYQSLFPTSRIVLVRCFTEDLFRTNAAYARLFKPAMDLVSSHTESGGQVLVHSFSNGGGNQVNEFAKAWKKKFGAKMPMRAQILDSSPTKGPWMKSHAAISASLPRTLFWAWVGGALVHLFLACTWLADLIRRKENTMVVLCRELNDETVYDNSVPRVYLYSRADMMVGFEEADEHAEIAMSKGWDVTKVHFEKSAHCGHIREDANKYWAAVMEAWKKGPRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IF90</accession>
    <name>R0IF90_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_164182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028241.1">
        <property type="nucleotide sequence ID" value="XM_008030050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IF90"/>
    <dbReference type="STRING" id="671987.R0IF90"/>
    <dbReference type="GeneID" id="19399024"/>
    <dbReference type="eggNOG" id="ENOG502SHGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070115_1_0_1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA83731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="346" mass="38695" checksum="D4318F555B7D38E8" modified="2013-06-26" version="1">MHIVTSIIIQALLLGLAFVVTCLRCWVRMRLENRKLTVVDYLVWGGWLCTLGWFTCSTKSLYILIDHPLDEETRSDSVDYLKTVFASVYFFDAGLYFPKASLVAFYWWLIPVGFKRLRIAIYVSAGVVSTSFLASILTDTLIAPNISDNWSIENQLQSTWNTFANLVINWVLNFGTDLLLFILPFFIVNCLTLRKRQRIGLVGVFSLGLITMGISLGRFIVYNMDYDLADADGNLWCTAEMCTAVIVVSLPFFKTLIMRSTPPNSTNRSNSGYVKGSSNQANAHGGSGFTSRTRGGPMDDEVELTLQDRERKGSLTPTGATDEARTPDGKDHVTLATDWTVTRDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IF99</accession>
    <name>R0IF99_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_164299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028396.1">
        <property type="nucleotide sequence ID" value="XM_008030205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IF99"/>
    <dbReference type="STRING" id="671987.R0IF99"/>
    <dbReference type="GeneID" id="19399084"/>
    <dbReference type="eggNOG" id="KOG4532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012621_0_0_1"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="313"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="694" mass="76978" checksum="2F18A3A2A9658E4B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJ84</accession>
    <name>R0IJ84_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Blue (type 1) copper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_81904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028930.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0IJ84"/>
    <dbReference type="GeneID" id="19405448"/>
    <dbReference type="eggNOG" id="ENOG502S40X">
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    </dbReference>
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    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="252"/>
        </location>
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        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA85210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="252" mass="25083" checksum="8F63B356324A85E7" modified="2013-06-26" version="1" fragment="single">MYFSRTAIVSALAGLSCAQSMPPAPAASGMAGMVMMHVVQVGGPNGSLAFYPNNVQAEPGDMVQFQFHPKNHSVVQATFDKPCTPIQNVMPNMTTAFFSGFMPTNASFEAKKEVLTYTIRVTDKKPIWFYCSQAKHCQAGMVGAINAPTTGAKTMEAFIALAAKATENITPGQAPGSGGSTGTSPTNGGNSTGSSSGGSSGGSNGGSRGGSGGGAAGGASGTSSSTLPQSTSGAISTISAQSFVGIAAAAFA</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908670">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IKI7"/>
    <dbReference type="GeneID" id="19403320"/>
    <dbReference type="HOGENOM" id="CLU_1960936_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="128" mass="14245" checksum="3214C2EE98530DC4" modified="2013-06-26" version="1">MPVSKYEIDAKADTVIVFKTPSPSFSPWSPAEVEGSMTTLDQGLASEDADQTISVKVAIVPDNESESIPNDTKGDEIWYYVFWRRLISTSFTMSVRCESQALRDVNEAGRYLAHGVPEKSCRIGKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IKQ6</accession>
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        <recommendedName>
            <fullName evidence="7">AA1-like domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_164086</name>
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    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027834.1">
        <property type="nucleotide sequence ID" value="XM_008029643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IKQ6"/>
    <dbReference type="GeneID" id="19398993"/>
    <dbReference type="eggNOG" id="ENOG502T4HA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797165_0_0_1"/>
    <dbReference type="OrthoDB" id="3672834at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51895">
        <property type="entry name" value="AA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343606" description="AA1-like domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="7">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="144" mass="14977" checksum="5F7CA6A052DEDC09" modified="2013-06-26" version="1">MRSQIFAGLALAAVVAAAPLECRASDEPITIDNASFVREDSNSNDNWDTITFLGFDLTTPSGTVSCSANSFPNPSVPSNVYACANAAYSFQISSRPGYDLYAITVTHKVSDSVTLTGTANVGCNGPIPKSCSQTRTGKATLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILV5</accession>
    <name>R0ILV5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_39794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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    <dbReference type="HOGENOM" id="CLU_2224829_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="106" mass="11368" checksum="E71358E1EE53DB31" modified="2013-06-26" version="1">MHLSVQHATGGTELSTKSDRIGPILAFSVSSTLPGRGGREFYASLFGSSGRYHDRHLQANGRSRSVKGRGSSGHYVLTLVMQPSRTRDVANRLLKGNSAGPMLVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IP28</accession>
    <name>R0IP28_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_134976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025319.1">
        <property type="nucleotide sequence ID" value="XM_008027128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IP28"/>
    <dbReference type="STRING" id="671987.R0IP28"/>
    <dbReference type="GeneID" id="19396284"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002512_0_1_1"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057912">
        <property type="entry name" value="OB_CYT4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25522">
        <property type="entry name" value="OB_cyt-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="544"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1043" mass="116907" checksum="1E46A19418E365B3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0IP35</accession>
    <name>R0IP35_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_89066</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025328.1">
        <property type="nucleotide sequence ID" value="XM_008027137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IP35"/>
    <dbReference type="STRING" id="671987.R0IP35"/>
    <dbReference type="GeneID" id="19405749"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="104"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA86705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="239" mass="25088" checksum="1EC146DD547824BD" modified="2013-06-26" version="1">MSAPLPASATSPANAPLQADATAAHPPAHQPDPTLESNDHGSSQGRLTTTGPSATAELASLKAKLRASLRLFNDFPKPGVLFEDIMPLFASPALHEDLLRGLELAVETQFGAPGKPDVVVGLDARGFLFGPSLALRMGASFVPVRKKGKLPGPCETAEYEKEYGSDFFQMQADAVKSGQNVLIVDDIIATGGSACAAGTLVKKLGGNVIGYLFIDEVPFLKGRDKLDAPVHTLLFAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0IS92</accession>
    <name>R0IS92_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_168856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024599.1">
        <property type="nucleotide sequence ID" value="XM_008026408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IS92"/>
    <dbReference type="STRING" id="671987.R0IS92"/>
    <dbReference type="GeneID" id="19400692"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_0_1"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="195"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA87705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="582" mass="64825" checksum="355677D96598C481" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISH0</accession>
    <name>R0ISH0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_150406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024662.1">
        <property type="nucleotide sequence ID" value="XM_008026471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ISH0"/>
    <dbReference type="STRING" id="671987.R0ISH0"/>
    <dbReference type="GeneID" id="19397063"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003430_0_1_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="712"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="957" mass="109318" checksum="B71A8D557795CED9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISH9</accession>
    <name>R0ISH9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_169010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="4">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="4">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908548">
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</entry>
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    <accession>R0ITP9</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
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        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mediator hinge subcomplex-like"/>
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    </dbReference>
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    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA88145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="188" mass="21359" checksum="F574489907B0568B" modified="2013-06-26" version="1">MEFIADQLKMQGVFQDWQYEQLYPSSGDNNSATTSATQQQTITTNAASIDHQNYLFRFLRSILLSYISLLGIMAADPTSEQKDQKLKDMMTMVANMHALINEYRPHQARQTLIERMEEQVRRKRAEVEGVRKMADKVREVLGSFGAVDGDDKAEHADAGRDENGVGKQQARKMDAQRDGWETLDEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IU26</accession>
    <name>R0IU26_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_27574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908548">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IU26"/>
    <dbReference type="GeneID" id="19403145"/>
    <dbReference type="eggNOG" id="ENOG502S89Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA88111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="523" mass="57910" checksum="7AA71AB8B1D7671D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVQ9</accession>
    <name>R0IVQ9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_184048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024030.1">
        <property type="nucleotide sequence ID" value="XM_008025839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVQ9"/>
    <dbReference type="STRING" id="671987.R0IVQ9"/>
    <dbReference type="GeneID" id="19402013"/>
    <dbReference type="eggNOG" id="ENOG502S731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025399_0_0_1"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="308"/>
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    </feature>
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        <location>
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            <end position="525"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="EOA88676.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    <sequence length="536" mass="57721" checksum="59456C67AE0FB51E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IW93</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">SETTUDRAFT_168116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
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    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA88886.1"/>
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        <source>
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    <sequence length="88" mass="9949" checksum="4B0696802E174382" modified="2013-06-26" version="1">MGYKPFRSTYYDDRMRASPALLRARAPYLVKNTITGFAICSLVIGIYTYTINAISQDEFEDVIVPDKPLDRSAQPTTQALQQAMDARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0IWG8</accession>
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    </protein>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
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    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008025393.1"/>
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    <dbReference type="AlphaFoldDB" id="R0IWG8"/>
    <dbReference type="STRING" id="671987.R0IWG8"/>
    <dbReference type="GeneID" id="19396982"/>
    <dbReference type="eggNOG" id="KOG3875">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034386_1_2_1"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="301"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="373"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="436" mass="45599" checksum="714202C01A82C5F1" modified="2013-06-26" version="1">MSSPSPPKPWETSTGATSASVGLTGSTSSTAPSTTTATAASPSSAAAPPLPSVPDSLSTVANRNATTYSGMNNRYTSPYASGYGGMNTYNSPYSTMGGGYGSMYGGMGGMYGGMGGMYGSMGGMYGGMGGMPGDPNSSLTQSFSQSTAATFQLIENIVGAFGGFAQMLQSTYMATHSSFFAMVSVAEQFGNLRQTLGSVLGIYTVMRWIRTAIAKLTGRPLPADATALTPASFAAFNGRMPDGSPAPPKPSKKPFVVFMLAVFGLPYLMGKLIKALARSQEAEEQRRMLENPQAGQVLDPNKLEFCRVLYDFTPNANMQGMDLSVKKGDMVAVLSKSDPMGNASEWWKCRSRDGRVGYLPGIYLETIQRKTPAQITSGSQVGSPASSRSQTMTSSSAAARTAAMAVSKESDKAGPKVETKAGDMGVESFQKGAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>R0IX85</accession>
    <name>R0IX85_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_175928</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023017.1">
        <property type="nucleotide sequence ID" value="XM_008024826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IX85"/>
    <dbReference type="STRING" id="671987.R0IX85"/>
    <dbReference type="GeneID" id="19401432"/>
    <dbReference type="eggNOG" id="KOG1360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_6_0_1"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902117">
        <property type="term" value="P:positive regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="187"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA89171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="622" mass="67074" checksum="104DF3ABEAE1F960" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXL8</accession>
    <name>R0IXL8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_37201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022441.1">
        <property type="nucleotide sequence ID" value="XM_008024250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IXL8"/>
    <dbReference type="GeneID" id="19404224"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2062916_0_0_1"/>
    <dbReference type="OrthoDB" id="10556102at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13494" checksum="CFB027708549A90D" modified="2013-06-26" version="1">MQAPDLTPIDFVPDTGARTSIIKRKYLEHYPRVNIKQASKDEQMEITGIGSTAIFAEHYIEDFPLTMQAVDGEIIRLYRRVYVVDKLPVPCIIGNNILRLNGVNIMFNDVLGDFAALRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXV0</accession>
    <name>R0IXV0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_167435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022565.1">
        <property type="nucleotide sequence ID" value="XM_008024374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IXV0"/>
    <dbReference type="STRING" id="671987.R0IXV0"/>
    <dbReference type="GeneID" id="19400172"/>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_1_1"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA89580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="229" mass="25455" checksum="1A097F476067A896" modified="2013-06-26" version="1">MSSQFGFQSQCNAQPAEQQTPRAISLPIPYVTETTGGGWKTSDIFSRLLQERIICLNGEVDDYMSANAVAQLLFLEADNPEKPISMYINSPGGSVSAGLAIYDTMNYIRCPVSTICMGIAASMGSLLLAGGAEGQRYILPHARVMIHQPSGGYRGKASDIADHAKEILRIRDKLNRIYLTHITKKRTLEEIEKYMERDYFMDAQEAVDFGLVDKILERREAPAKEGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYC2</accession>
    <name>R0IYC2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_167546</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022694.1">
        <property type="nucleotide sequence ID" value="XM_008024503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IYC2"/>
    <dbReference type="STRING" id="671987.R0IYC2"/>
    <dbReference type="GeneID" id="19400217"/>
    <dbReference type="eggNOG" id="KOG4513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
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                <person name="Barry K.W."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
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            <dbReference type="PubMed" id="23236275"/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="19"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        <source>
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    <sequence length="128" mass="13304" checksum="2006CDE35511AC9B" modified="2013-06-26" version="1">MQFSTIALLFCAAFTVSAAPGAEMLAKRSCGTLTGTALQVCQDACKATCTVATLGVAQKLCTAACDLPPLKARAEEEEDVADEEDDTDDLAERSIGKSVCDAACDVTCNSTVLALDQLECLKVCKGKC</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
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        <text evidence="1">Belongs to the AHA1 family.</text>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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            <end position="151"/>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="100" mass="11291" checksum="8E1A9BAB953D9560" modified="2013-06-26" version="1">MHLLFRALFPTTTTKHQPPSRAPVPTNTLASAPYTISIRSPNKNWLQGTSPIRSRPINIRPPQAFCRANLCYPDVAATHRDEAYFPQTFCTGHKHQAFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNF0</accession>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029760.1">
        <property type="nucleotide sequence ID" value="XM_008031569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNF0"/>
    <dbReference type="SMR" id="R0JNF0"/>
    <dbReference type="STRING" id="671987.R0JNF0"/>
    <dbReference type="GeneID" id="19399372"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="291" mass="30144" checksum="456A6C3CD5BF4C88" modified="2013-06-26" version="1">MASSSKRVDQIAGHLNYPKGMLAGQTAIITGSGQGIGAEAAKLFAKEGAKVVIADVDGQKAEGVVAEIKAAGGSAIAVPGDVLDDEYIKTLIAKAAEFGGGKIHIIVNNAGYTWDGVIHKMTDKQWHTIVDLHGTAPFKIVRAAAPYFRVKDGEPRNIINISSTSGVHGNAGQINYALAKAGVQGMTKTIAKEWGPQFGVRANTVAFGHIQTRLTAAKEEGAFITTPDGQKVALGIPQAQMGAAQADPHADIPLRRPGTATEAASAVLAVASPLFGYVNGETIKVTGGRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0JR33</accession>
    <name>R0JR33_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_120461</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029256.1">
        <property type="nucleotide sequence ID" value="XM_008031065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JR33"/>
    <dbReference type="STRING" id="671987.R0JR33"/>
    <dbReference type="GeneID" id="19395816"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="108"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA83583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="568" mass="61955" checksum="94BB92C7AAC6C1E4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0JSZ8</accession>
    <name>R0JSZ8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_164429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028557.1">
        <property type="nucleotide sequence ID" value="XM_008030366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JSZ8"/>
    <dbReference type="GeneID" id="19399128"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_1_1_1"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA84188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41282" checksum="BAB630D0E9C2FAC0" modified="2013-06-26" version="1">MFPPAQGLRLDIDAISQIFGSISIACWIVVFSPQIIENWKRSSADGLSVVFIVIWLLGDFFNIIGAVLQGVLPTMIILAVYYTLADIVLLLQCFWYKGFTLRDDFKKPMNESDQDSEVSEQSPLLAESRPQSNGSPYTNQNGNGIEVQRPRISDYERRGSGHSQGSFRERFLSIDGTHLSPVTPLIDDPACGYGNGAVVTSPPPSQSNLQTIVFNVSTVILVCAAGVFGWYLSARNSTAPNPPDEHDPSSDATLHFNLWGQISGYVCAALYLGSRIPQLLLNYRRKSTEGISMLFFLFACLGNLTYVLSILVYKPKCGGLACHGGQARAEYGKYIAVNMSWLLGSFGTLLLDAGVFVQYFMYRKDEDESSDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JV49</accession>
    <name>R0JV49_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_142838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030869.1">
        <property type="nucleotide sequence ID" value="XM_008032678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JV49"/>
    <dbReference type="STRING" id="671987.R0JV49"/>
    <dbReference type="GeneID" id="19396690"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_5_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="130"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA81384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="594" mass="65494" checksum="96D5AB714E20CD65" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0JV91</accession>
    <name>R0JV91_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_179526</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027441.1">
        <property type="nucleotide sequence ID" value="XM_008029250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JV91"/>
    <dbReference type="STRING" id="671987.R0JV91"/>
    <dbReference type="GeneID" id="19401685"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_1"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
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        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="14">
        <location>
            <begin position="43"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA84933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="448" mass="48627" checksum="653667000EAEA979" modified="2013-06-26" version="1">MPETQIQPVDPQKLGKIAFRQSQDLIDDWDIEYDESVQAGDQFGNLKAAARDLVDTDVPVAFPTETVYGLGADATRSAAVREIFARKGRPADNPLIVHIHSLPQLRALLAGKLDVTGDGKIDGRDAIPEIYRPLIERFWPGPLTIILPTPENTILAPEVTAGLSTFGARMPRSIIALSLLRLCGRPLAAPSANASTRPSPTAAEHVYDDLNGKINRIIDGGPCEVGVESTVVDGLSSPPAILRPGGVTVEQLRQCPGWENVVVGYKDKQAEDSSKPRAPGMKYRHYSPKAAVLLFEAGAQQPAPEELKSKSRIGIIRTKSWKPILDLNGEKVKTTDSNGWKACCTPETPASVAADASSLRQSNLVRSVMQHQIPRSDHYIVKPEALHVWDINLGADTEDIARGLFSALRELDKKGVESIFVEGIDDKSGDDIAAAVMNRLRKAAEIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0JW36</accession>
    <name>R0JW36_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_163862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="Barry K.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="351" mass="38737" checksum="C2D91817E7CAB23F" modified="2013-06-26" version="1">MPGHLRTRLKRVLTAGSNKLAKPEEPESDFYKPGEKMPPLKYRRAVDPEHKKKLEAFSFATAWRRHSNASLYSPMGSRLPSRRSSFRRRSRSRSMHRSRRGSCSSEYDPESEWVDSGIGASIAGDDRPANIKEASDDEGDVLNVGLSRNPTEDPRDARRKQSQGPGRTSDARQPSRPATASDRTRQASQPFSAEELEMALQKSHLAATREESDRSAGESPFEDFDDPSPFLRPRGGSIYVPYNGQGTPPKLPFWGTAYPSCDDTLSAGHFSRRASVFLSPDESCTPQYEGGESYFSHADAPGLSQARRASVFVAADDNVCACPTPPREEPKRKVHPCAPCDAVAAILARPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWG7</accession>
    <name>R0JWG7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_173663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030237.1">
        <property type="nucleotide sequence ID" value="XM_008032046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWG7"/>
    <dbReference type="STRING" id="671987.R0JWG7"/>
    <dbReference type="GeneID" id="19401260"/>
    <dbReference type="eggNOG" id="KOG2038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003417_0_0_1"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="442"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="754"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="877" mass="98943" checksum="2E7C28C455BDE359" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0JX85</accession>
    <name>R0JX85_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_100446</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031479.1">
        <property type="nucleotide sequence ID" value="XM_008033288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JX85"/>
    <dbReference type="STRING" id="671987.R0JX85"/>
    <dbReference type="GeneID" id="19394793"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA80882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="308" mass="33694" checksum="801970C4C592255F" modified="2013-06-26" version="1">MPAEMHLFVDKHVRYVQSLDTRKDELEYWLTEHLRLNGLYWGLTALHLLGHANALPRSDILDFVVSCLHPHGGFGAAPGHDAHMLYTVSAVQILATLDAFAELDERIPGARHKIGLFIANLQDAETGTFAGDAWGEQDTRFLYGALNALSLMGLLDLVDVAKAAQYVDSCANFDGGYGTSPGAESHAGQVFTCVGALTIAGRLDLVDRDKLGAWLSERQLNNGGLNGRPEKKEDVCYSWWVMSSMAMLDKLHWIDAAKLTTFILQCQDPELGGLADRPGDMVDVFHTVFGIAGLSLLKYPGLEEVDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYN6</accession>
    <name>R0JYN6_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_96403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029671.1">
        <property type="nucleotide sequence ID" value="XM_008031480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYN6"/>
    <dbReference type="STRING" id="671987.R0JYN6"/>
    <dbReference type="GeneID" id="19406231"/>
    <dbReference type="eggNOG" id="KOG4690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062297_2_0_1"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="221" mass="24434" checksum="6A01C4134320D9CA" modified="2013-06-26" version="1">MGLQNSNRIQRRFKGYIAPEGEQARPITGFYEALDMLKKPLSQVQSLSHTSPEPPKEPPKTPKEETFAKARIIFGSTTALEERRQEIMKSSQNIAGVLVPPRPEEPDNCCMSGCVNCVWDMYRDEMEEWAEKHAQARAAMQAQRQEAKGTGSMVAGEATPSHVATSMDDDGGGSETNWDGGLDDTDKDKLFADIPVGIREFMKTEKKLKQAQKQAETAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYQ2</accession>
    <name>R0JYQ2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_142823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030864.1">
        <property type="nucleotide sequence ID" value="XM_008032673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYQ2"/>
    <dbReference type="STRING" id="671987.R0JYQ2"/>
    <dbReference type="GeneID" id="19396688"/>
    <dbReference type="eggNOG" id="ENOG502RRIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011673_1_0_1"/>
    <dbReference type="OrthoDB" id="5408102at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="580" mass="65353" checksum="D690D1610CBCE991" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZJ1</accession>
    <name>R0JZJ1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_166011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031023.1">
        <property type="nucleotide sequence ID" value="XM_008032832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZJ1"/>
    <dbReference type="STRING" id="671987.R0JZJ1"/>
    <dbReference type="GeneID" id="19399672"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
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        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="180"/>
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    </feature>
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        <location>
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            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA81607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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        </source>
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    <sequence length="354" mass="38507" checksum="23769F3A17D857FC" modified="2013-06-26" version="1">MPECAASNDYDGRMGTRISSIFVILVASTFGAMFPVLARRSRHKFVPDWVFFVAKYFGSGVIIATAFIHLLAPANEALTNECLTGVIAAYPWPEGIALMTIFLMHFLELMTMRYANFGGDHQHDASHTHAAIPAAASNSSSIEETKGHDIEAAGPGNPNIRGDDHLGHQRQHNAEGEYGSELEPRHLVPSDYAAQLTAVFILEFGVIFHSIFIGLTLAVAGSEFITLYIVLVFHQMFEGLGLGSRLAEVPWPASRRWTPYFLGLGYGLSTPIAIAIGLGVRQSFAPESKTTLLSNGIFDSISAGILIYTGLVELMAHEFMFSPYMQNGPVSRTLKAYALMTLGAGLMALLGYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0F6</accession>
    <name>R0K0F6_EXST2</name>
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        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_141802</name>
    </gene>
    <organism evidence="8 9">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032118.1"/>
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    <dbReference type="STRING" id="671987.R0K0F6"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="9983560at2759"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
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        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343742" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="591"/>
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    </feature>
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            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA81947.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="591" mass="64808" checksum="2CD1EFA8F8C9AA76" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0Q6</accession>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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        <name evidence="7" type="ORF">SETTUDRAFT_155823</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008030837.1"/>
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    <dbReference type="AlphaFoldDB" id="R0K0Q6"/>
    <dbReference type="GeneID" id="19397562"/>
    <dbReference type="eggNOG" id="KOG2533">
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    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
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            <end position="358"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA83269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53030" checksum="44B23D61CED56940" modified="2013-06-26" version="1">MASYADEKGDVAAIERMESKISSSDAAINRFTPEEQKNIIRKVDLRLIPTLGFMYCVSLMDRTNLGVAMVAGMGVDLKLTSERYSTVVLLFFITYVALQPPATVVLRKLGPKLFLPSIVVIWGAVMIAFAFVKEWTTLIPLRLLLGIFEAGFFPGSAYLLSCWYKRYELQKRNTFFFLIGMLSSAFSGILGYLFSLLNGYGFQAADPTKSAPNTPVGFGPGLSGWRWIFMLQGIITVAIGLVGWYYIVDFPELAAKPSKIQKKFLEQDEVDFVVARIQQDRHDVVAEEFNLRKYLAGSLDLKVWGFALIYMFTTTITYAIAYFLPIILKDGMGFSVAASNCLVAPPYVFAGFVMMGLAWAGDKYQVRSPWVIANGVLALIGLPMIGFSKNFGANNIRGQWKRALCSATLVGAGGIGGILGGTVFRTQDAPDYFLGIVACMVSAGFIIILSLMLNLKFWRANKRAASGGKVIEGLEGFRYTL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR43662">
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    </dbReference>
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            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="356" mass="38653" checksum="3564687A1119779B" modified="2013-06-26" version="1">MFALLFFAALAQAIPQFGGNQRFTMLRFGCAQTVIDRIDPLVNPGQAPSPHMHQIAGGNAFNTTMQSTDISKLATCTTCGYSEDLSNYWTANMYFKARNGTYKRVPQIPNRDLFNDKYTGKTTGGFVVYYVSGGKGDVTAFKPGFRMLVGDVTSRVSKNRKSQSCFRCYTAPNFGGDNAAPCQDAKLDTEGFPTTPCPGGIRSNILYPTCWDGVNLDSPDHKSHVAYPVNGPALFTGTSTGGACPSTHPVKIPQVMLEIVWDTSKFNNKADWPADGSQPFVLSMGDNTGYGQHGDYVFGWKDDSLQKAMDDAKGCMGANCGTLKTQQPADGNKCVVPNRVREDHDGWMTALPGMSM</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="R0K3I8"/>
    <dbReference type="STRING" id="671987.R0K3I8"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
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    </feature>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87628.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30511" checksum="3AFEE9D841D3ED14" modified="2013-06-26" version="1">MAIGQRITAPYTGPLDPTRFVTSWALPSSLLFGYRALLALYAFTTLFTIFGWNGAHGRSAESRHSFSYFTNLTYWGLAFYYAFAAAHTGSYWLTGTSFLARWPKPLQVAHSIFYSTIVVYPWIVTIVFWGLLAANFPTTFSIWSNTSQHALNSLYAFCEIFFPCTKPLPWLDLIPIILLLALYLGLAYLTHATQGFYVYPFLDLQRHSSGVVAGYIIGILVAAIILFLIVRYLIALRVWVTETKLGMKGKVSPRVSASAELEDISLHNTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0K406</accession>
    <name>R0K406_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_93166</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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    <dbReference type="STRING" id="671987.R0K4Z3"/>
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        <property type="entry name" value="PHDIOXRDTASE"/>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
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            <dbReference type="PROSITE" id="PS51384"/>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="62211" checksum="9C0A581278EF5143" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0K569</accession>
    <name>R0K569_EXST2</name>
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        <recommendedName>
            <fullName evidence="9">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_163530</name>
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    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051642">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:establishment of mitotic spindle orientation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="137"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="353"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="373"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <begin position="394"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="414"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA84644.1"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
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                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Manning V.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="337" mass="37185" checksum="C3A01632E15515C5" modified="2013-06-26" version="1">MLASFRLRYALALLPLLPFVKPDEYQVKNLIVDTDIFDAIDDAAALLLACTLPNTNLLAVNVNVNSTYSALAASAIINHYGYHSVPIGLPRPYGNITSSEPFGGEYASKVAAEWSGGSVPWFQVNKTWNPVELYRKTLSEAKNSSVTIASIGFMGSISGLLNSTADQYSPLDGYALVKAKVKELVVMGGGYLPERSLDQEYNFARQEAPHVVNTWPDCVPMTFLGAEVGVEVLTGARLTTCGPSDDPVRASFVWWGGTNHSQYSWDHLTMVYAGEGLGKWFEYGNANGYNYVYPNGTNIWVEDERRTSQHYLKLKISNTTVAKELDRLLLRGAWKYA</sequence>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908670">
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    </dbReference>
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    <dbReference type="AlphaFoldDB" id="R0K7S7"/>
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    <dbReference type="GeneID" id="19397167"/>
    <dbReference type="eggNOG" id="ENOG502S8FX">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42545" checksum="EB8CAD38C5933503" modified="2013-06-26" version="1">MLLFTHEIDPFADTIIILKNPCKNFAPWDETLVPAQIEVVGGVENPSVQLAEPASGPTQSEDDEIHYLVSSRHLMLASPWFRRTLTRKEFAESSKNPSDGRYHIQANDWDEKALLILLNIFHVRTRQVPAIVSLEMLAKIAVLVDYYELENAEAIERDTKNWIASVRRNVAIPSSYCRDLMLWICISRVFCMCKEFEKATAVAIKESKGWIQTLDLPIHQGITSSIDRIRCNALEHVISELHRLLRVYRDFNYSCPHNPSHSFQCGAFLFGALMKYMERWGCLLPQPENPFMGISLNEICNRSGMAENTKWWVKSDCYDYYRGYDHEKFEVHSCSLNAKIDEVVQDAMAKVRGLKLQDFRDNSQISFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8A8</accession>
    <name>R0K8A8_EXST2</name>
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        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_159596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EOA89178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008024832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8A8"/>
    <dbReference type="STRING" id="671987.R0K8A8"/>
    <dbReference type="GeneID" id="19397953"/>
    <dbReference type="eggNOG" id="KOG0872">
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    <dbReference type="OrthoDB" id="6354873at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:C-5 sterol desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Fatty_acid_hydroxylase"/>
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        <property type="entry name" value="Sterol_Desaturase_Related"/>
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        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="352" mass="41270" checksum="29E67C19621EC17F" modified="2013-06-26" version="1">MDIGLEVADAFLFDPLYATLLPAWPSRTTANASLSGLREEPTAFARPHATWQYEPATQFFSTTPSKYAYMSQWTRDDWRRQALSLYLITWLFGVLVYFVFASASYFFIFDKSTFNHPRYLKNQIKLEMKQANIAFPIMAIFTVPFFLAEIRGYSKLYDTVDQGPGLWYNYMQFPFFLLFTDSLIYWIHRGLHHPAVYKHIHKPHHKWIMPTPYASHAFHPLDGYAQGLPYHIFPFLFPLSKFAYVLLFVTVNIWTVLIHDGEYAHNSAIINGAACHTMHHLYFNYNYGQFTTLWDRLGGSYRKPSDELFQKELKMCQSAWKKQAEAVDRMVQQVEGDVDFRTYVSEEGKKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAA6</accession>
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            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
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        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_167633</name>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022801.1">
        <property type="nucleotide sequence ID" value="XM_008024610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAA6"/>
    <dbReference type="STRING" id="671987.R0KAA6"/>
    <dbReference type="GeneID" id="19400251"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043530">
        <property type="term" value="F:adenosine 5'-monophosphoramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA89913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="135" mass="15010" checksum="13F8408DC9526235" modified="2013-06-26" version="1">MSSASCIFCKIIKGEIPSMKIFESDNTLAFLDIGPLSKGHSLIIPKYHGAKLHDIPDDQLAEVVSVTKRIAVAQNLQDYNILQNNGRIAHQMVDHVHFHLIPKPNEQEGLGVGWPTKEADKGELSKLLEEIKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAF3</accession>
    <name>R0KAF3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="9">ALO</shortName>
            <ecNumber evidence="4 9">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_32411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="4 9"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027027.1">
        <property type="nucleotide sequence ID" value="XM_008028836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAF3"/>
    <dbReference type="STRING" id="671987.R0KAF3"/>
    <dbReference type="GeneID" id="19403649"/>
    <dbReference type="eggNOG" id="KOG4730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_1_1"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="34"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA85187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="587" mass="67346" checksum="992F8D89CB78E19C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KB07</accession>
    <name>R0KB07_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_72477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025850.1">
        <property type="nucleotide sequence ID" value="XM_008027659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDM4"/>
    <dbReference type="SMR" id="R0KDM4"/>
    <dbReference type="STRING" id="671987.R0KDM4"/>
    <dbReference type="GeneID" id="19397379"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA87454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="351" mass="39143" checksum="10CF50EFF7C584DB" modified="2013-06-26" version="1">MADMNQETIQQKIQLARRDAEALKDRIKRKKDELADTTLRDVARDRVEALPRLTMKTKRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYSPSGNYVACGGLDNICSIYNLSAREGPTRVARELSGHSGYLSCCRFISDKRILTSSGDMTCVLWDLETGSKVHEFADHLGDVMSLSINPLDHNQFVSGACDAFAKLWDIRQQKCVQTFAAHDSDINAIQFFPNGNAFGTGSDDASCRLFDIRADRELASYQIPEPVCGITSVAFSVSGRLLFAGYDDFECKVWDVLRGERVGTLQGHDNRVSCLGVSNDALSLCTGSWDSMLRIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDS1</accession>
    <name>R0KDS1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_158499</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021694.1">
        <property type="nucleotide sequence ID" value="XM_008023503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDS1"/>
    <dbReference type="STRING" id="671987.R0KDS1"/>
    <dbReference type="GeneID" id="19397828"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003051_1_0_1"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="685"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA91023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="960" mass="104926" checksum="570CCAC2A843F96B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KF79</accession>
    <name>R0KF79_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_168767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA87974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KF79"/>
    <dbReference type="STRING" id="671987.R0KF79"/>
    <dbReference type="GeneID" id="19400659"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="V-type proton ATPase subunit"/>
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    </dbReference>
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        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA87974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="366" mass="41437" checksum="22FE575AC414594C" modified="2013-06-26" version="1">MEGLYYNVKYGYIEGIVRGYRNALLTSQNYSNLTQCETIDDVKLQLAPAYGDFLNSLPPNPSTSALAAKTTDKLVAEFRYLQANATGSLSKFMEYLTYGYMIDNVALLITGTLHERDTRELLERCHPLGWFETMPVLCVATNIEELYNSVLIETPLAPYFKGSLSHQDLDELNIEIIRNTLYKNYLEDFHQWINSCPEIAGTPTADVMSEVLEFEADRRSINISLNSFGTELSKAERKKLYPELGKLYPEGTLMLSRADDVEGVRIAVESVADYKMFFDQTGLSQSSNGGVGNMAGGVGGETRSLEDLFYQKEMEISKLAFTHQFTHAIVYAWVKLREQEIRNITWIAECIAQNQKERIGNYISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFD2</accession>
    <name>R0KFD2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_135175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025404.1">
        <property type="nucleotide sequence ID" value="XM_008027213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFD2"/>
    <dbReference type="STRING" id="671987.R0KFD2"/>
    <dbReference type="GeneID" id="19396297"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="214"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
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    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025714.1">
        <property type="nucleotide sequence ID" value="XM_008027523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGU2"/>
    <dbReference type="STRING" id="671987.R0KGU2"/>
    <dbReference type="GeneID" id="19405777"/>
    <dbReference type="eggNOG" id="KOG2594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024534_3_0_1"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA87262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="385" mass="42130" checksum="CBA4A1159E55F73C" modified="2013-06-26" version="1">MPGKHIAAAPDEPCRRCKAAAVLVVRSEPLCHDCFARYVHTKCIKRLESFRVNFGAEKQRRVLVPLSFGFSSISLLHVLDVHLKTQKSKTGRTGFEISAVHVQEPGEAAGSADELLAKIRAQYPDHEYASLPLHDVFRLVPDDAALRSLVPQSEQNAEAGTEEQLVHMINSLSSATARADVISTLRTRLIVEHARLSGCESILWGDSTTTLAQKTLAETAKGRGFSLPWQISDGLSPFGLHFHYPLRDVLKKELVSYVHMSDASLAQLIDETSSQGSTHASTSSKNTTIDDLMKQYFESVEENFPSIVANVVRTTSKLEVRPDALSDPQCSLCSMPVPGGRFGIHGWGGDQHDSSDNVEPESTRQNICYGCTRSLPKALSSANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KH07</accession>
    <name>R0KH07_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_160425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023939.1">
        <property type="nucleotide sequence ID" value="XM_008025748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KH07"/>
    <dbReference type="STRING" id="671987.R0KH07"/>
    <dbReference type="GeneID" id="19398036"/>
    <dbReference type="eggNOG" id="ENOG502STGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298782_0_0_1"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="963" mass="109048" checksum="E6DB95B2E19C7286" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0KH27</accession>
    <name>R0KH27_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_163337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025801.1">
        <property type="nucleotide sequence ID" value="XM_008027610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KH27"/>
    <dbReference type="STRING" id="671987.R0KH27"/>
    <dbReference type="GeneID" id="19398737"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
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                <person name="Barry K.W."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Han J."/>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_176435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023663.1">
        <property type="nucleotide sequence ID" value="XM_008025472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KIN9"/>
    <dbReference type="GeneID" id="19401468"/>
    <dbReference type="eggNOG" id="ENOG502SDPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095773_0_0_1"/>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354216" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16784" checksum="51D79B96A60EA8DB" modified="2013-06-26" version="1">MAAMASMWWGWSDVCCALLSPPPPSDLLARHFGTTPKITEHGPEWAQSRLPFLAKTFTGTRQCEDYFQMMSQVLDLSLPSDAFPGKDGFIVDAEANMVSVVGKGTLTSRKTGKAWDEHFIYRFSEFDHEGRIGHWEIWADPLSAWEAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0KK54</accession>
    <name>R0KK54_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_66493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022517.1">
        <property type="nucleotide sequence ID" value="XM_008024326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KK54"/>
    <dbReference type="STRING" id="671987.R0KK54"/>
    <dbReference type="GeneID" id="19405325"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_2_2_1"/>
    <dbReference type="OrthoDB" id="5425161at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="172" mass="19199" checksum="70A8D8A5231D3CBB" modified="2013-06-26" version="1" fragment="single">QLGNREWVTVIQGVGASGRRIPPFVVFAGKVLINVYLAWLEHFNTHTKRHTIGGYQLLIINGHESHCSIDFQDLCKEKNIILLCMPPHSSHLLQPLDVACFSPLKRKYGDAVSGLARNRTHYISKETFLLAFKAAFKQSITKENIQASFRGAGLVPHDPQAVLSKLDVVVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KMJ8</accession>
    <name>R0KMJ8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_175424</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022221.1">
        <property type="nucleotide sequence ID" value="XM_008024030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMJ8"/>
    <dbReference type="STRING" id="671987.R0KMJ8"/>
    <dbReference type="GeneID" id="19401396"/>
    <dbReference type="eggNOG" id="KOG3657">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001524_2_1_1"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
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        <reaction evidence="1">
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</entry>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
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    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023182.1">
        <property type="nucleotide sequence ID" value="XM_008024991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNA1"/>
    <dbReference type="STRING" id="671987.R0KNA1"/>
    <dbReference type="GeneID" id="19400333"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA89397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="308" mass="32765" checksum="F738729464C3F191" modified="2013-06-26" version="1">MATELPTTNGNGTAQDGENNFAVKAGLARMLKGGVIMDVVNAEQARIAEEAGASAVMALERVPADIRAQGGVARMSDPKMIKEIMDTVTIPVMAKARIGHFVECQILEALGVDYIDESEVLTPADAIHHVSKHPFRIPFVCGCRGLGEALRRIAEGAAMIRTKGEAGTGDVIEAVRHMRTVNAEIARAKGMTDEELRVYAKELQVDYALLKETAKLGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDAAKRAKAIVQAVTHYNDPKVLMEVSMDLGEAMVGINCSTMGEQEKLAKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNP6</accession>
    <name>R0KNP6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_36181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
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    </dbReference>
    <dbReference type="RefSeq" id="XP_008021261.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNP6"/>
    <dbReference type="GeneID" id="19404095"/>
    <dbReference type="HOGENOM" id="CLU_1816997_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="142" mass="16131" checksum="E3FB95A7BFF30B9B" modified="2013-06-26" version="1">MTIHMAIIPRPLSMPESASMPACLPACLPVRLSVWRRFDGYELDMRIYCMSMPNHLFHVHARRQPLSPAMSASAPEACLQLARLAALCLHHRGKLHAPTHTCIHTYTLPTPYCHTTKPPIAMCIQYQYMCTYISRCRLGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPK9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_166842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021659.1">
        <property type="nucleotide sequence ID" value="XM_008023468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPK9"/>
    <dbReference type="GeneID" id="19399949"/>
    <dbReference type="eggNOG" id="ENOG502SPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622542_0_0_1"/>
    <dbReference type="OrthoDB" id="10037289at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
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        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="420" mass="47482" checksum="7D9EC9CA8881790E" modified="2013-06-26" version="1">MPSAKKQKTARGSKASSSSTASAPAPPPNKNSSATNEQDGASSEEGEDPAPYDYICIPRHFFDFQGENWLARQNKSSDYVSNKTFNKRYKSYLEEVVKMNLFKASPSDHPGHKWVIMWNAYLKMDLLGRKAEYCNPDNFNMNMYTDWRGWGMQEILEREMIAFDKAFRSKGPMRIEDMWVIISAIGLWLNNEDYMDVLIHNEDGDTTCELIGLLVCALLTVLAAIEDAGELKPDSRFLDLTLVIGYYLELLHDLPDYGIEGDCIRGRKEVVNYFKKGNLDTDKALSTTKVRLEKLEKVNEYDEEIPQESTEENTGSGVIQASQSSTPAKGKGKAKGKGKRKRNEDDVEGETSATKKKADVWDWTGNFKKYKKGRWPVMGGEHYDITKMSRSDRAEAAYDGKDPLADIPVKDLKNNLIDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPQ0</accession>
    <name>R0KPQ0_EXST2</name>
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        <recommendedName>
            <fullName evidence="5">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_25103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPQ0"/>
    <dbReference type="GeneID" id="19402870"/>
    <dbReference type="HOGENOM" id="CLU_1864957_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344092" description="WAP domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15413" checksum="81C1BA157E7E1350" modified="2013-06-26" version="1">MLVAVALVGLLVLVNASPTVTDRKAVTGEQPSMSTQSVNQNNEENTYHCDDDPSAIACPAMDDCSAQGPLAIAKRDTPDTQAQENKRYECSKDHTGVLICRYGFCSTDHYCKKNTKCSDKCACCKKGRDILRDIGVFKDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQS8</accession>
    <name>R0KQS8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_167081</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA90137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008023858.1"/>
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    <dbReference type="STRING" id="671987.R0KQS8"/>
    <dbReference type="GeneID" id="19400032"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="729"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA90137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="844" mass="92208" checksum="3418108270E3D445" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTA1</accession>
    <name>R0KTA1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_84840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020361.1">
        <property type="nucleotide sequence ID" value="XM_008022170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTA1"/>
    <dbReference type="GeneID" id="19405483"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="117"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA92139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="581" mass="62996" checksum="C4D944C353456A57" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0KUM5</accession>
    <name>R0KUM5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_152582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020678.1">
        <property type="nucleotide sequence ID" value="XM_008022487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KUM5"/>
    <dbReference type="STRING" id="671987.R0KUM5"/>
    <dbReference type="GeneID" id="19397207"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_2_1_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000147">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="549" mass="60770" checksum="6A5C315F74A047C2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0KVQ2</accession>
    <name>R0KVQ2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_162404</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA91837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
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        <property type="entry name" value="Peptidase_M41-like"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="273"/>
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        </location>
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        <location>
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    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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    </feature>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KWW2</accession>
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            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA92177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="273" mass="29998" checksum="DD7A7060BB4A971B" modified="2013-06-26" version="1">MSSKDDPAAACPVDHKTREAWLAQARAQNANAPPNPHSTPIPTPDAPPAASSRPTAKSAVQQSCDSSSLDQSTSSPPPTSTGIFSQIRLGTEREVSTIPRALPDDAAPASARPANNERDTGADKKTGNWIYPSEQMFFDAMRRKAYDPSAPDMRTIVPIHNAVNERAWHEIKNWEKGRGSEACGGPKLASFSGLSTSLTPRARWKSFLGYQAPFDRHDWVVDRCGTKIEYVIDFYAGKDEGKVGKALNFYLDVRPKLNSWEGIKTRVLKFWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0I532</accession>
    <name>R0I532_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_99885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031394.1">
        <property type="nucleotide sequence ID" value="XM_008033203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I532"/>
    <dbReference type="SMR" id="R0I532"/>
    <dbReference type="STRING" id="671987.R0I532"/>
    <dbReference type="GeneID" id="19406456"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_3_1_1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342838" description="Fungal lipase-type domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="119"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA80770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="388" mass="43139" checksum="591A85183FB3FB24" modified="2013-06-26" version="1">MGSLRGLLLCCLVLVTPFAAHSSHAHQQPLFRGTATANTTLISQKLFWELEELARIVDISYCVGTAGLGIKRPFSCASRCADRDFETFDLVTAWNTGPFLSDSCGYIALSHHPAEPRLIIAFRGTYSIANTIADLSTIPQEYIPYPGDDDENDSSDFISPPAGAEDGNPPPAEPPKCDNCTVHTGFYSSWLNTRKVILPYVTEALERYPDYKLVLVGHSLGGAVATLAGLDFKARGWDAHVTTFGEPRLGNKEFNAYVNERFNITANHEHNKLHRVTHVGDPVPLLPLAEWGFSMHSEEIFISESSLPASVSDVYYCEGDEDVNCIAGSDADKPAWGVPSRFKFWQLFFAHRDYFWRLGLCLPGGDPRDWYDKYQGDNDDHLPEVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5R8</accession>
    <name>R0I5R8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SETTUDRAFT_144150</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8K6</accession>
    <name>R0I8K6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_24117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030644.1">
        <property type="nucleotide sequence ID" value="XM_008032453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8K6"/>
    <dbReference type="STRING" id="671987.R0I8K6"/>
    <dbReference type="GeneID" id="19402745"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_8_1_1"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012316768" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA81731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="134" mass="14548" checksum="357235ACD5FEF0FD" modified="2013-06-26" version="1">MKVALLIALATAAMADIINNEHLKTEVLTPAKCTRKTQAGDKINVHYRGTLTDGTEFDASYGRGEPLSFTVGQGQVIKGWDQGLLDMCPGEKRKLTIQPDWAYGSRGAGPIPPNSVLIFESELMSIDGVEKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9L8</accession>
    <name>R0I9L8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_165548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030385.1">
        <property type="nucleotide sequence ID" value="XM_008032194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9L8"/>
    <dbReference type="STRING" id="671987.R0I9L8"/>
    <dbReference type="GeneID" id="19399511"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_1_1"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="392" mass="43817" checksum="56EE25E928D9755C" modified="2013-06-26" version="1" fragment="single">MPVNILAQAFNEGLDSIPYGWTILKAACVFAVVYLFKWFFNGAANGSERNMHSKVVMVTGGTAGIGAEVVRGLASRGAQIVLLVRQPLVDPFLVDYIEDLRTQTGNELITAEHVDLESLHSIRQFATKWVDNAPPRRLDMIILCANTMTPPGGKAMQTEDGLESTWGLNYIANFHLLSILSPALRAQPADRDVRIIVGTCSSYMGGKLPSMDEKSKKNGKSEPGQLDFTPSTVYATSKLALMTFAVAFQKHLSNYSRPDKKPMNARVIMVDPGWTRTPGMRRYLTFGSLWGLAIYVITWPIWWLVLKSGDQGAQTFLYAAMEAQWGRGEGGYLLKECRRSIWTRKEIDDEVLQKKLWESSEKTIEILEKEGAKKRAAEKKQKEKSESKSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAL2</accession>
    <name>R0IAL2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_40322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908852">
        <property type="protein sequence ID" value="EOA82356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAL2"/>
    <dbReference type="GeneID" id="19404615"/>
    <dbReference type="HOGENOM" id="CLU_1397126_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="195" mass="21259" checksum="9040F304F0FDBC2F" modified="2013-06-26" version="1">MTSTHATHAASSCAPPILASANNTPNIILAKNNDDDDGDDNNTNNNNNNNNNTINNNNNNNNNNNNNNNNNNNNNNNNNNNRNVNTRAALTLLLRPARLRLPLMPCQVSRTRNRRPRVPPIHTIHVHAAQDSPMYVCIVALCFATLNRTRFTMVASGRAVHERPAVRAVGMGTTPVPVPVPAPPASTQVPKLMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAN4</accession>
    <name>R0IAN4_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_156164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAN4"/>
    <dbReference type="STRING" id="671987.R0IAN4"/>
    <dbReference type="GeneID" id="19397596"/>
    <dbReference type="eggNOG" id="ENOG502QSYC">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
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    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="473" mass="52926" checksum="EDD1FDE8D79FE71C" modified="2013-06-26" version="1">MSVRQSFQLRPSGWEHDPAEERFKLSTIDYTLNCAYNHYAVFFRMKDARKIQAVDFLRAGLERTLSQARHMCGTIEADPEGGFSFVKKRDSAVQFVVHCLHPLGGHPSLDDIEKAHFSGRSGLRDINLWGIPELTWGERPEAEPDRSPVVSGYQVTSTKGGLVLSMHHHHYSCDVMGWNAFTRQLSANCYAVAKSTSFPPWDAACLDVSRFTKDVPQNSLVEGPPVAQKHPGHVEQQAVLFHLPKSKAAALKELAKPADSASPWISTYDAVCAYIWRMLSRVRAPHYKTDPSTVLWMGEAVNMRPRLSNPLPERTVRNVIAGAFSDMAPVAPLTAGEVMSEAPLSTLAVYIRRLTESCNEGHFLGLLDAIAAIRNKRALALCLDARPPMSMFVTDHRSADISDFDFGFAKPIAYRHFWGDTKSPGVIVIYAPVRSSANADEGWMFTLTMEKELVPRLRETAEWAKYFEYRGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBG7</accession>
    <name>R0IBG7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_95619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029771.1">
        <property type="nucleotide sequence ID" value="XM_008031580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IBG7"/>
    <dbReference type="STRING" id="671987.R0IBG7"/>
    <dbReference type="GeneID" id="19406178"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_0_0_1"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA82745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
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    </evidence>
    <sequence length="341" mass="38245" checksum="96D43A47BD1CF6EA" modified="2013-06-26" version="1">MGWFWADSTPAAPAARVAPHPMPRGSMEPPPECPMHKKPAPPVVAEKTPQGACPYVPPEKSSAGASEPPPKTGLLARLNPLNNMFSDLSNERAEKQAQTLPLERETSTIPKGDGSLWEYPSPQQMYNAMLRKGYTDTDITAVESMVGVHNFLNEGAWAEIMGWERRFSRGLAEGYEICKKGEDVANFMLGTAENPFDTTTWDQKDIPPPKLLRFTGRPTEPTPKSQILQWLGYVMPERFGTAPPFDRHDWFVERCNEKGCKEIRYVIDYYEGAPEATGEPVFYLDVRPAVDGPTSAAERLIRSGTDLWWRASGGVTREIKRLEAEKKAKEDEWAAKSRQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICF8</accession>
    <name>R0ICF8_EXST2</name>
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        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_181030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343490" description="CFEM domain-containing protein" evidence="10">
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            <end position="471"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
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        <property type="match status" value="1"/>
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            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
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            <end position="380"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA82991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="446" mass="50158" checksum="06E24F981A2BAB23" modified="2013-06-26" version="1">MAVSTDAAPQPKAPRPRWVLHIQAQFWRVLMAIGMVLHRLARPLPPRPAFHRDIEATVSPIKGKFRLHFYVPKDYKRYKKLKGTKRYPVVVNFHGGGFVLGTAHDDARWCGVVVDQVGAVVVSVDYRLAPEYPFPTAVEDGADALLWLAQHADELMLDADRFAISGFSSGANMSFTVPLCLQGELFDRTPSGTRIVDERAGSLPPYAYSHTLTPAGSRVPLVRQQSRLDRIAILRKTGSSSLSLITSYKDSSGVSVMSEGSNAVLKIRGVVSFYPPTDYTQTRAQRRATCVRVDQNLPAVFTDLFDDSYLQPPSLDLSHPWLSPGVAPNHMLHALPDDIVLFCCEWDMLLAEGERFRDRLQKDLGKRVHYHCVPGVPHAWDKAPNPLRESPGARQQYMVACKELKRMFDIEEEEDDAQSQHQDMPCRQYHRSMDASNLHLTAYQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICW6</accession>
    <name>R0ICW6_EXST2</name>
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        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA83031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029994.1">
        <property type="nucleotide sequence ID" value="XM_008031803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ICW6"/>
    <dbReference type="STRING" id="671987.R0ICW6"/>
    <dbReference type="GeneID" id="19399445"/>
    <dbReference type="eggNOG" id="ENOG502SJSY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046029_0_0_1"/>
    <dbReference type="OrthoDB" id="10061782at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA83031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27237" checksum="07A9C4E2667A0A7A" modified="2013-06-26" version="1">MTGQDTAAGGAAYTPVFLRVIYDNLILGLYCSYVWRCSSAKLLKFYDETVTSTGKQVKASNMGSEPVRLLDIGVGTGYFLEHASIPAGAEVTLIDLNENCLETAAARVTKSHPSTLVRTVHADFLDSDMESNSAITPKRLNEAKFEVISCFLLLHCLPGPPRRKAEAVARLRRHLNTNGVIIGATVLGNGAQHNLPGKAIMWWHNRVGIFDNHPDDVQGLVGPLEEVFKTVKWEVVGATLLFEARHPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IEW3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_21189</name>
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    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027992.1">
        <property type="nucleotide sequence ID" value="XM_008029801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IEW3"/>
    <dbReference type="STRING" id="671987.R0IEW3"/>
    <dbReference type="GeneID" id="19402410"/>
    <dbReference type="eggNOG" id="ENOG502SDW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190851_0_0_1"/>
    <dbReference type="OrthoDB" id="2555959at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="67" mass="7547" checksum="AAACE5B49EE9B7F3" modified="2013-06-26" version="1">MAVWQWFKSMQPKTRMFIGVGVMAYAGAGLYLSDVAEEKLGFTPTEKDKEELRDALPKIAAVEKRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IFI2</accession>
    <name>R0IFI2_EXST2</name>
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        <recommendedName>
            <fullName evidence="12">V-type proton ATPase subunit</fullName>
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    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_164240</name>
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    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
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        <property type="protein sequence ID" value="EOA83826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008030118.1"/>
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    <dbReference type="AlphaFoldDB" id="R0IFI2"/>
    <dbReference type="STRING" id="671987.R0IFI2"/>
    <dbReference type="GeneID" id="19399052"/>
    <dbReference type="eggNOG" id="ENOG502S76V">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_170555_1_0_1"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
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                <person name="Han J."/>
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    </evidence>
    <sequence length="67" mass="7096" checksum="85FFB5AA959CA256" modified="2013-06-26" version="1">MLTTCTTGNTPDVVNTRSAHDGSSPAIAMPPQDRSREDPPSPPPQPPPSPAHWSRIVSIESLAPLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHJ9</accession>
    <name>R0IHJ9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_169750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908704">
        <property type="protein sequence ID" value="EOA84461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027891.1">
        <property type="nucleotide sequence ID" value="XM_008029700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHJ9"/>
    <dbReference type="GeneID" id="19401001"/>
    <dbReference type="eggNOG" id="ENOG502SRM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_4_0_1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA84461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="252" mass="29452" checksum="DA32DCB3586D392C" modified="2013-06-26" version="1">MSPLLYSKVSSESSREDSIEQQENVRRPSRWRRIKEKVHILRWPVTFFLLITILFCEFSILRHQPSKPQVGSDINGIIPTFSLEKKVFHNDKRFASDHRTTESINATMREWDNLIPFGGGFLEVADYTSYDLPPPMHFPNIPGKQVFSLAIFHQLHCLMHLSDFMDKLVVQIRNRDFSLDDNFLWHNDHCFNYIRHAIMCFGDTTLEGQTLTPGLEHVPGTDGTGATHMCRNFDEIREFAEKRRLSEKKEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIP4</accession>
    <name>R0IIP4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_32050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026994.1">
        <property type="nucleotide sequence ID" value="XM_008028803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIP4"/>
    <dbReference type="STRING" id="671987.R0IIP4"/>
    <dbReference type="GeneID" id="19403616"/>
    <dbReference type="HOGENOM" id="CLU_1907986_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="162" mass="18480" checksum="107BC4654FD9524B" modified="2013-06-26" version="1">MDQRLPFLDGEFQRIANDLRQVVEQFVSSMIASTTNLNSCIKHLSNLDVCCSEHGASPKAVGQAAHILLERDTAEGIENEIAIEDMVLIVSRDIKWDGISMPKPKYSKTTTIRNLESWQKTGQRGTIMSWLRSQQVRYNPDREDIYLLCPNEYNNVVAKNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJU9</accession>
    <name>R0IJU9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Late sexual development protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_20913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026946.1">
        <property type="nucleotide sequence ID" value="XM_008028755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJU9"/>
    <dbReference type="GeneID" id="19402373"/>
    <dbReference type="eggNOG" id="ENOG502SM3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045147_0_0_1"/>
    <dbReference type="OrthoDB" id="5293813at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37427" checksum="4C4C6BB3679981DD" modified="2013-06-26" version="1">MAVSVAYAAPFTARGNSKGVSFPLANGFPNPSQSAINQIQKDAQGTLPNGAPPPSMTPEGLTNLKLIALNELFEVAFFTELAANISSRAPGYDLGEKQGYVLDAIKAIVAQEELHLLNANGALKHFNQAEIQPCRYSFPVTDFESAIGLAQTFTDLVLGTLQDVSDIFARSQDYGLVRAVASVIGNEAQQDGFFRSQQKKIPSAQPFLTGSARDFAFTAIQSFVVPGSCPNIHTIPLKTFKGLTIKTKKVQPKTQHLKFAFSKKDAGMFQIEHLRVVYLNGQSVPVVKPLMDVQTKGDSVTFSAEFPYDEFVMDGLTIAAVTSGADSFDGPDAVAQKTLFGPGLIELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IK71</accession>
    <name>R0IK71_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_164126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA88015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IT61"/>
    <dbReference type="STRING" id="671987.R0IT61"/>
    <dbReference type="GeneID" id="19397057"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="499"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="355"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA88015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="631" mass="70517" checksum="60849D07F1815619" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0IT64</accession>
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        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008026509.1"/>
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    <dbReference type="AlphaFoldDB" id="R0IT64"/>
    <dbReference type="STRING" id="671987.R0IT64"/>
    <dbReference type="GeneID" id="19398104"/>
    <dbReference type="eggNOG" id="ENOG502SIA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411114_0_0_1"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
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        <property type="match status" value="1"/>
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        <location>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="48"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0IV86</accession>
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        <recommendedName>
            <fullName evidence="3">Glycogen debranching enzyme</fullName>
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    </protein>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023082.1">
        <property type="nucleotide sequence ID" value="XM_008024891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IWX3"/>
    <dbReference type="STRING" id="671987.R0IWX3"/>
    <dbReference type="GeneID" id="19396029"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_1"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="118"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA89260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="431" mass="46339" checksum="CFE5D60F8E504D85" modified="2013-06-26" version="1">MTENVRVLLVGNGGREHALAWKLLQSPATEHIYVCPGNGGTATLSPKVTNVTHVKDTDFAGLVQFAKEKEINLLIPGPEAPLVAGIVDYFKDNGLESIKAFGPSKKAATMEGSKTFSKDFMKRQNIPTAAYENFSKYEDAKAYLDTISHSVVIKASGLAAGKGVIIPQSKEEAQAALKDIMLDREFGAAGDEVVIEEFLEGDELSILTFSDGHTIKSLPPAQDHKRIFDNDQGPNTGGMGTYAPTRIAPRDVLDRIDKEILQPTIDGMRNEGFEFKGVLFTGLMMTKDGPKVLEYNVRFGDPETQSLLALMEGDLAQVMVACADGRLQDVDVKVSDRSAATVVVAAGGYPGSYAKGTVMTLDPTPEDVVLFHAGTSFSDNTLKTSGGRVIASTATAPTLEEAVAKAYEGVNCIHFDGMQFRKDIAGRALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0IX69</accession>
    <name>R0IX69_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_147848</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023185.1">
        <property type="nucleotide sequence ID" value="XM_008024994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IX69"/>
    <dbReference type="STRING" id="671987.R0IX69"/>
    <dbReference type="GeneID" id="19396936"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030471_1_1_1"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA89400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="523" mass="58062" checksum="E4207604641DF7FE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXB2</accession>
    <name>R0IXB2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_127772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA89206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023044.1">
        <property type="nucleotide sequence ID" value="XM_008024853.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19396026"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="168"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA89206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="436" mass="49209" checksum="7731A9D0E06934E2" modified="2013-06-26" version="1">MLSGILIFNQKGENLIFRAFRNDCRPRLADVFRIQVISNAQVRSPILTLGSTTFSHVKHENIYLVAVTKSNANAALVFEFLYRLVGLGKAYFGKFDEEAVKNNFVLVYELLDEILDFGYPQNTETDTLKMYITTEGVKSERTMEDSSKITMQATGALSWRRADIKYRKNEAFVDVIEDVNLLMSATGTVLRADVNGQIIMRAYLSGTPECKFGLNDRLTLGEDHLHQPSGNKAGAKATRAAAGSVTLEDCQFHQCVKLGKFDADRIISFIPPDGEFELMRYRATENVNLPFKVHAIVNEVGKTKVEYSIAIRANYGSKLFATNVVVRIPTPLNTARITERTSQGKAKYEPEHNNIVWKIPRFTGQSEFVLSAEASLTSMTNQKAWSRPPLSLSFSLLMFTSSGLLVRYLKVFEKSNYSSVKWVRYMTRAGNYEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXU8</accession>
    <name>R0IXU8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_167884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
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    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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    <dbReference type="eggNOG" id="ENOG502SZ4D">
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    </dbReference>
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    <dbReference type="OrthoDB" id="4138121at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020301">
        <property type="entry name" value="Mrx7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10906">
        <property type="entry name" value="Mrx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="EOA89696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="75" mass="8903" checksum="0D454379FBEA514B" modified="2013-06-26" version="1">MGPWFALFEAWAVARLIRSPAFNRAVQKAYRKIHRLPDFEQKNGGGRTGPSSFDHFKDEVKNQFRELTWQKRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZE5</accession>
    <name>R0IZE5_EXST2</name>
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        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_147190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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    <dbReference type="OrthoDB" id="68581at2759"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="GOC"/>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
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        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="167" mass="18474" checksum="FDF4276DB8F797B1" modified="2013-06-26" version="1" fragment="single">LARIRYLEETRVTKVVSGGYMSGALSEQGELFLWGMPCPGGSGELLLLRNQGGHEQQQQQQQQQQQQQQQQQQQEEQDEFVKVVDVRIHGAEASVYDVAIGHGHVLVAAECEGERAVFAAGENSRGQLGLDGPDFCNVFREVVALRGKRVVQLYAAGWSSYVVTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1C3</accession>
    <name>R0J1C3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_166556</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021379.1">
        <property type="nucleotide sequence ID" value="XM_008023188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J1C3"/>
    <dbReference type="STRING" id="671987.R0J1C3"/>
    <dbReference type="GeneID" id="19399840"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000002">
        <property type="entry name" value="Sphinganine-1-phosphate aldolase Bst1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA90571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="568" mass="62170" checksum="20A2D47D9731FDFB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2S5</accession>
    <name>R0J2S5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_17962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020026.1">
        <property type="nucleotide sequence ID" value="XM_008021835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2S5"/>
    <dbReference type="STRING" id="671987.R0J2S5"/>
    <dbReference type="GeneID" id="19401697"/>
    <dbReference type="HOGENOM" id="CLU_1939439_0_0_1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="130" mass="14918" checksum="FF8835228812AEC1" modified="2013-06-26" version="1">MLTNACEIGPSERLWELESLPGKNTITNVQAAMIIAYHMSTNSLEQVGAVYAKRAREMGEKLDLFEPNYCGLGMNMNEARVFTAWALFSWQAMFSFYQSRRPYFRETPRIPLYLHRKDIYISPLGGSIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2X4</accession>
    <name>R0J2X4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_36575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021318.1">
        <property type="nucleotide sequence ID" value="XM_008023127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2X4"/>
    <dbReference type="GeneID" id="19404152"/>
    <dbReference type="HOGENOM" id="CLU_2185577_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="109" mass="12280" checksum="1B582C0877E715B7" modified="2013-06-26" version="1">MADKPHVTRWCEQPLIHPAPRHILPRAMFNSMEAQAEKQASVDLFMETQHQLEAQPDGGIVSKANVRKDSGTCHGPDYLRRKTPFPGDDDDAVLKMPKGLKDWKECGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3D3</accession>
    <name>R0J3D3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_162018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3D3"/>
    <dbReference type="SMR" id="R0J3D3"/>
    <dbReference type="STRING" id="671987.R0J3D3"/>
    <dbReference type="GeneID" id="19398248"/>
    <dbReference type="eggNOG" id="KOG0086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_6_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
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    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="333" mass="35640" checksum="27F4F9BD5F9965E7" modified="2013-06-26" version="1">MGRNRAVSNASTRSSEPPLQELGSMYDYLAKVILLGPSGAGKSCLLHRFVKSEWRVLSSQTIGVEFSSKIVHIADRRRSPSSSASRKRMKLQLWDTAGTERFRSVSRSYYRGAAGAILVYDVSSWRSFEQLQTFLNDARALAGPDLTIILAGNKSDVENEGEPVGVAGSHGASGGGGYASYGSTPSSESGLPPPTPSSHSSRASLNANLHASYTIAPEGREVPTETASRWAGQNGIPVAVEVSALNGENVDELFNRLARMILAKIELGEIDPDDPASGIQYGDLGWDDGGGSVKSGFGDDGVRYRRRGKKPGGLGEWEEVFRLGGSRRKRGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JHU9</accession>
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    <protein>
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            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_166386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008033344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JHU9"/>
    <dbReference type="STRING" id="671987.R0JHU9"/>
    <dbReference type="GeneID" id="19399783"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140672_1_0_1"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA80963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="106" mass="12060" checksum="B2F4BCAF44883530" modified="2013-06-26" version="1">MPKEVKQKSGLIVGLNAGHKVTPRTPAPRISRRKGFLSKRTAFVREITKEVAGLAPYEKRIIELLRNSKDKRARRLAKKRLGTFGRSKRKVDEMTKVIAESRRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLH7</accession>
    <name>R0JLH7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-terminal nucleophile aminohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_97211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030416.1">
        <property type="nucleotide sequence ID" value="XM_008032225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JLH7"/>
    <dbReference type="STRING" id="671987.R0JLH7"/>
    <dbReference type="MEROPS" id="T02.004"/>
    <dbReference type="GeneID" id="19406293"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_5_2_1"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="414"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="64835" checksum="C4DBF1BE1C3926FF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JPA5</accession>
    <name>R0JPA5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_96534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029988.1">
        <property type="nucleotide sequence ID" value="XM_008031797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JPA5"/>
    <dbReference type="STRING" id="671987.R0JPA5"/>
    <dbReference type="GeneID" id="19406246"/>
    <dbReference type="eggNOG" id="ENOG502SPBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024655_0_0_1"/>
    <dbReference type="OrthoDB" id="5355161at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="438" mass="48961" checksum="9482C078F3A478A3" modified="2013-06-26" version="1">MPKHTESNACGACARSKRRCGRQMPSCARCAERGWTCIYPRGTSRLTSTQALMPSAERYLSPIIDSGLPDKVADSAPTSDTGPIFSEDLALDLNLSPLANSCFAIASPSSGIPDLTALKADWFTAPDSWHISHEWNRAVMGTNTNADMKIYIARVQSWLQRWINTGSNPFIHKKLYSVNFPASVQIAYATLASYIHRTPSNTDTVLKIVEDRSTALLRDNGAVLQEEKWVCRQEEEEDHSVDLFAQLARLHALMTYQMIGLFDGDIRARYFAEGRLALQNAWAIKLFHAAGSVLPNADGCAVQLVGSLPRWSDYAQQQWYSWILAESIRRTYMVAVSIMPIYTALQQGWAKCPGGIKFTNRSGLWGATSAVEWEKQCREKGAGFLHRSECDWFLDNATPGDVDEFGIAVMDMTFRSDLLQRWREKGRGVWSEGHVGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0JPF5</accession>
    <name>R0JPF5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_21763</name>
    </gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 7"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028981.1">
        <property type="nucleotide sequence ID" value="XM_008030790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JPV4"/>
    <dbReference type="STRING" id="671987.R0JPV4"/>
    <dbReference type="GeneID" id="19401216"/>
    <dbReference type="eggNOG" id="KOG2696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="9">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="278"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="513" mass="59118" checksum="2760B375655045B7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JT90</accession>
    <name>R0JT90_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_174460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031376.1">
        <property type="nucleotide sequence ID" value="XM_008033185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JT90"/>
    <dbReference type="STRING" id="671987.R0JT90"/>
    <dbReference type="GeneID" id="19401325"/>
    <dbReference type="eggNOG" id="ENOG502QW7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008109_0_0_1"/>
    <dbReference type="OrthoDB" id="5229455at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA80749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="747" mass="83073" checksum="564025B2767277B5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JTB3</accession>
    <name>R0JTB3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_21679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353790" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="109" mass="12042" checksum="A96E6D81EC35D791" modified="2013-06-26" version="1">MHSSMLAIFFAIGAPVVSAVATVNSELGCVCMERAPRGHRDQANYDRTQGGCDLYGGFVTNTQDFYGRATYYCVISDNSITPATWDQDWCRKHWPTSSYGFCNKATPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JVJ6</accession>
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        </recommendedName>
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    <organism evidence="8 9">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029316.1"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AIM24"/>
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        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
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        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
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    </dbReference>
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        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU363045"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <sequence length="385" mass="41953" checksum="F8115AAB21AE677B" modified="2013-06-26" version="1">MLRPAAAPWRSLCRPRTPTAHTSSAAAARCINISATTSPSEPALQQAVSVEGTATPSPMHSPDARFEVIGTPFSLLSVSLSASQTLYTRRGTLVGLSGKSENTLSTLSILEPFQRAPVGIPFLYQKVSSTSPVTALVSTKNPISSIVSVNLDGRDDWIISQRQALLAWTGLTLRLKPQYNVKLGLANWGNTYITGRGLLALTGNGQIYQVQVKAGESYVAHPSNVVAYTASNTPPMPFRFKSSNVRFQVPDLGFGSMIQNTDFFRNMSKTATWRALATTYYTLKTWLRRTVWGDRLFLRFEGPTTMLVQSRASRISDVLTLRDVDEIADSPPGAVQDAISRKIKEEIKSIGEEGTKAPIPNTDPSGTVRHPTIKDGKPEFEKPSV</sequence>
</entry>
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    <accession>R0JVU5</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="R0JVU5"/>
    <dbReference type="STRING" id="671987.R0JVU5"/>
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    <dbReference type="eggNOG" id="ENOG502RYFW">
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    <dbReference type="OrthoDB" id="5302380at2759"/>
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    <dbReference type="InterPro" id="IPR058317">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="392" mass="45638" checksum="EAAFB20F71D2FDF4" modified="2013-06-26" version="1" fragment="single">MLCTLQQEIQVMYDLDLDARPGMSARERSVQMITNYLSQHGLDDLRNNVRHALGLLAWAEQDTVRWRQGYLESFVHLAGLMTPELEERPDFKRLSVVTRRNLGIAGKTLQLRIMEAEDKLATFDFNDLWEDTPKATSSPVYQSYQSFRQFLISHFTRIYGNWPPSSDRPWLNRKIVQGLQEDFGSLYDYLVDRDVIWNPREERATRKWEMSHRRIDGFNADLPELGMTDILVTYDVKSGYAHIPHPYPLLPREVPKGVKEKEKKGFFASLKKEKPKDATKDAKAHLQLSIIFTDATNIEKLDANFNGSTLIDKFEQFEIMTDLRHMSPREARLGRWVLLYGTLQVLSTLSIDVQGLKHTEGVRYFLNTDLKRMPEWVNHGQTEHLEATQHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWA9</accession>
    <name>R0JWA9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_98269</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
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            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41066" checksum="9446A8C07166DBAC" modified="2013-06-26" version="1">MEARAHPSPPPASSSAPFAAVDSGIDAGSSSEFDQENSGNHALEAHDDTSEASTDEGYADSDASSFLSSILSEVRRGVEIEGRLYPSYGKHEYGMPIDEKELDRNDLQHHKYTLLLRDRLFVAPIAESRFDHGNSRVLDLGTGTGIWAIDMADKYPKTEVLGVDIAATQPAFVPPNCVFEIDDVEDEWPYRPAHFDFIHGRDLMTAIRDWPRLMAQAYTHLKPGGWIQLASTIPGALSDDDSIPENSGYLESARLYFEIAEKMGAPLDAPRSWSAQMKEAGFTNVEDEIYKLPMGTWPRSKRLRTVGKLEQIMILDGGFEAYMLRGYTQVLGGKAEDLQIILALAKREVRDPAIHTYVQFHITYGQKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWT8</accession>
    <name>R0JWT8_EXST2</name>
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        <recommendedName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_164055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWT8"/>
    <dbReference type="STRING" id="671987.R0JWT8"/>
    <dbReference type="GeneID" id="19398985"/>
    <dbReference type="eggNOG" id="KOG3353">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="10254664at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
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    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA85413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="186" mass="20586" checksum="A470EECCA634A739" modified="2013-06-26" version="1">MVRYGATSIDGAKSARARGSYLRVSFKNTRETAQAVNGWKLERALTYLGNVLEHKEAIPMRRYAGSTGRTAQGKAFGVSKARWPVKSAEILIGLLKNAEANADTKGLDTSNLIIKHIQVNQAPKQRRRTYRAHGRINPYMSNPSHIELILAEGSEAVQKSSSALDRRLNSRQRGRAVRKAITASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JX07</accession>
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            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_165532</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030367.1">
        <property type="nucleotide sequence ID" value="XM_008032176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JX07"/>
    <dbReference type="SMR" id="R0JX07"/>
    <dbReference type="STRING" id="671987.R0JX07"/>
    <dbReference type="GeneID" id="19399504"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA82024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="499" mass="54213" checksum="AFCEF459D4FCD637" modified="2013-06-26" version="1">MSETLAKLSTPQTGEYEQPTGLFINNEFVKGVDGKTFEVINPATEEVICSVAEATEKDVDIAVAAARKAFNGPWRKETPENRGRLLVKLADLFEQNAELLAAVEALDNGKAYNMAKNVDLPAAAGCLRYYGGWADKIEGKIVDTTPDTFNYIRKEPIGVCGQIIPWNFPLLMWCWKIGPAIAAGNTVVLKTAEQTPLSAYVACKLIKEAGFPPGVINVITGFGKIAGAAIASHMDVDKVAFTGSTVVGRQIMKAAAGSNLKKVTLELGGKSPNIVFADADMDEAINWVNFGIYFNHGQCCCAGSRIYVEESIYDKFIARFRERAAQNAVGDPFAKDTFQGPQVSQLQFDRIMSYIEDGKKSGATVETGGKRKGDKGYFIEPTIFSNVTEDMKIQQEEIFGPVCTISKFKNKEEVIKIGNSTSYGLAAAVHTTNLNTALEVANALRAGTVWVNTYNSLHWQLPFGGYKESGIGRELGEAALDNYVQTKTVSIRLGDVLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXK8</accession>
    <name>R0JXK8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_165656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030490.1">
        <property type="nucleotide sequence ID" value="XM_008032299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXK8"/>
    <dbReference type="STRING" id="671987.R0JXK8"/>
    <dbReference type="GeneID" id="19399544"/>
    <dbReference type="eggNOG" id="KOG0896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063065_4_0_1"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="139" mass="15607" checksum="D4A958697BBCCEE5" modified="2013-06-26" version="1">MGAKVPRNFRLLEELEKGEKGLGAEACSYGLDNGDDLLMSDWNGTILGPPHSVHENRIYSVSIHCGPDYPDTPPEIKFTSKINLPCVNPQNGKVDPTKLPCLAQWKREFTMETILIELRRYMALPQNKKLPQPPEGTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYA8</accession>
    <name>R0JYA8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_22452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029335.1">
        <property type="nucleotide sequence ID" value="XM_008031144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYA8"/>
    <dbReference type="GeneID" id="19402555"/>
    <dbReference type="HOGENOM" id="CLU_1526100_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="176" mass="19426" checksum="DD15662AB5B609C6" modified="2013-06-26" version="1">MPWAPPPTPPPPPPPPPVPTNVGQLQLLNRMLDIISRPESSQPGIRIKGAATEDETTRKRSASAYEVDVETDTPQQARTGRPIAMPRRQFARARTPTPRQMQPAPARPTQPASTQQFFADAQARNNEEHASSSSTIAGAVGNGVHDMLDVDDMPDPNEDWPQHSWSAQTYVRFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYB5</accession>
    <name>R0JYB5_EXST2</name>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_156228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029598.1">
        <property type="nucleotide sequence ID" value="XM_008031407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYB5"/>
    <dbReference type="GeneID" id="19397605"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_0_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF60">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57577" checksum="3EDD74B0E0D42E98" modified="2013-06-26" version="1">MGHDIETAPQAVRVSVDDGSLKPTKVGREELADIVPPHESYEGRHRFDPHATWTAEEERRVLDRGNVSNALADNLLKDLGLTSDDYNNGTTIQLVCFLAAEFPVQFLTKRYGFKYILPSMMFAWGTASWAQSWMHDRTSFYLGRAAIGLCEGGFIPGVILFATYFYKSKELSMRLAAFWSTLNIARVISALLAAGILEMRGIGGKPGWFWLFLLEGILTVIIAVVSFLYLPVSPTSTKNVLWPNGWYTEREEVIMVNRILRDDPAKGLTALKEPATFKDVRAAWSDSSMWGLYFIGLIAYIPASPVQGYLTLTLKRLGFSTFNSNMLTIPSAALQVITMLALAYSSDYFNERTFHCVFGEFWIMPLLIALLTLPDGGREWGRFSLITLISGYPYFHPLVSSWISENTFDVKKRAITAATYNVIVQIGSLISSQIYRKYDGPYYKQGNSVLVSICALSLVTFLVQRVVLMRINKKKQDTWDAMTSEEKAVYQADVVAREQDGNKRLDFRFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYH5</accession>
    <name>R0JYH5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_47751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026424.1">
        <property type="nucleotide sequence ID" value="XM_008028233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYH5"/>
    <dbReference type="GeneID" id="19405151"/>
    <dbReference type="eggNOG" id="ENOG502S5NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030288_2_0_1"/>
    <dbReference type="OrthoDB" id="3686371at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="179"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="621" mass="69572" checksum="773DF979733009E6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0A9</accession>
    <name>R0K0A9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear localization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_97011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
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    <sequence length="295" mass="32225" checksum="46AE2EDF6447F1FD" modified="2013-06-26" version="1">MAGTVHATHVLGLELTLPADLNSNNSFDSGASLMSNFNNGGFSLDHVSAFTAINDHSVAAGSTRTVSPKDIFNDGFGSAPPSTALTNLTSPDIGDSPFINDSFECSPMFNGEPNMTDTSDWFSLFPEQETKIPDAVYAPAISMPLERTISSQSMERSASSSTGSPIVLDNYTRRKSSVTNSPATNGISKSRRRKGPLPSITVDPNDKVAMKRARNTLAARESRQRKFDHVSTLEQRNSELMAEVEKWKSIAMAHGYSGHSKLEERGPHQVKATSEIYVDEKRNQNAYEWYGLDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0K279</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_92429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028231.1">
        <property type="nucleotide sequence ID" value="XM_008030040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K279"/>
    <dbReference type="STRING" id="671987.R0K279"/>
    <dbReference type="GeneID" id="19405973"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_566400_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="482" mass="51436" checksum="C57F09D2DD125AF5" modified="2013-06-26" version="1">MRTHIPNQSVQNIPGQCRSCGTCVRSQAPLNFFRMFRFGTAADSGRGDANGGRGSPSASGGDGDEDGEGRMVPIIIVGIRSIQPGSGTGQEDASIPPFLDALSSFPTPPTSPGDASIIQPPQNGTRFSHRRRASMGGFNFPTSHDGQRQHRANAQDRPRPWSSVTDSPPGPQPPPSTPATTLNLSAGPSGATTPATSTSPPSPTTQSSAPSRRNSFIRRGAGSTLEPTAEEPQAHPRNARPRRLSESDFTRYGAGAPRRRGVVEPDNNPGEGSRSWIIYVLGGSYPENHPILTTPSLFTDSPTYEDMMLLSSILGPAKPPVASEEDVASAPGLFRIHSNAGVLVAEAAEGDESIHLVPGARCLVCLCDFEADEEARKLVKRRLGCRHRRRHRCHAMPTLCCRSAATGETYQRCRRAWPPGCRRPRARRPWQRRPARAAGTARRPGPRPGAAAGRFPYSRPRATASVACAGAQSCCVAAAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2L8</accession>
    <name>R0K2L8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_140843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029703.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2L8"/>
    <dbReference type="GeneID" id="19396586"/>
    <dbReference type="eggNOG" id="ENOG502SR19">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062455_0_0_1"/>
    <dbReference type="OrthoDB" id="5420711at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="325" mass="36363" checksum="AFEB626DE26644A5" modified="2013-06-26" version="1">MTATSLVDGRLPASSLLRLPLEIRLMIYEYLLLPSKTPCAGRGTSVANLIPDFHTYFSEDTNNDPFTLSVRTVDPWLGGHGARTWRKRSTYHVRTGPFLTTTAPTTYRVLLSPYTAHLRYTVPSLMCINSQIHAEASKILYSTYTFSFHMSVEAVVPFLSDLTPRSRASVRHLSLTKKALPYAKEFDRAEWAEMCAYLAAAAAANTSMEEGAPAMQLSTLQLQTIAGKPDEAWEAITPMTPSDFDTMLRMKNEWLGGRSDFGGVDLEWAEQVMAIRGLRDITVKALVERCARPVSEKQAFWVAFSKSVAEGKFGEWMRGRMLLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2M5</accession>
    <name>R0K2M5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_22600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029354.1">
        <property type="nucleotide sequence ID" value="XM_008031163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2M5"/>
    <dbReference type="GeneID" id="19402574"/>
    <dbReference type="HOGENOM" id="CLU_633353_0_0_1"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
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    </evidence>
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                <person name="Henrissat B."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="434" mass="48606" checksum="F9464C8A22327952" modified="2013-06-26" version="1">MALRGVASFMVVCGHLCTAFVPWLHRPAADPKTAPHLFQLPFFRLAVGGRSAVALFFLVTGYVNSIGPISKSRAGNYDAAFHAIARSALARSGRLILPTMIATIISWFMAQTNAYHMTKHVDAQWIRQGWHRQEPSLWMALTSLFKAQVETWTIGWDEYDGTQWTLHLFLQGAFLVYTTMLATVLVRPKARFIIYAVMYAYFWQVGKEITVGSIEGLNIVTGMFVAELHNHYKDSATSVLPAPIPAIMIVCGMFMAGFPQEAFGNARWSDTMSKIMLSLTAEKTDIRRYWDHLGAATVLLGIFFSRNARKLLTSPVFNFLGRVSFPVYLIHNTFIKTVLTWMIYLPSAMNPPVNEKGEQQDLQRGSVPHILIAIAVFYYILYRSASLWVRYIDPVCANIVNAATKWATGEPQPKDIRPILGNGSTADKTTVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5U6</accession>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
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    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027406.1">
        <property type="nucleotide sequence ID" value="XM_008029215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K5U6"/>
    <dbReference type="STRING" id="671987.R0K5U6"/>
    <dbReference type="GeneID" id="19398851"/>
    <dbReference type="eggNOG" id="KOG3218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058320_0_0_1"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="161"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="234" mass="26897" checksum="8F16E279B6B04982" modified="2013-06-26" version="1">MDGEKYSPSLIRLWRVWRTAKEMMNDRGYMVVEDDMTMSLDEFSRRYAREDGEPDRSRLNFSCQPSEEMLAKYTDAPTKKNPNPLPSIGTIWVEFNADENVGMKQLREYMAHLVNGSFHSGIMVTVKPMTGMAIRLLRGATSITDGPKGGVEVFVEQDLLVNITKHELVPKHVLLSDEEKQQLLQRYRLKQTQLPRIQSTDPVAKYLGLRRGAVVKIIRKSETAGRYASYRWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6P1</accession>
    <name>R0K6P1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_168456</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024012.1">
        <property type="nucleotide sequence ID" value="XM_008025821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6P1"/>
    <dbReference type="STRING" id="671987.R0K6P1"/>
    <dbReference type="GeneID" id="19400560"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000119">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="231"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA88643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="326" mass="35390" checksum="BA992E6428FAC8BB" modified="2013-06-26" version="1">MAQVQEKAAESTSSVPHSAAAPQSDNVAHALAGAGGGLLSMALTYPLITLSTRAQVESKRAQSSTLNAARRIIKREGVAGLYAGMDSALFGITVTNFVYYYWYEWTRSFFEKAALKAGRASSKLTTIESMIAGAIAGSATVLMTNPIWVINTRMTTRKSEDSESLPGGAPAPKAPSTLGTLFALVRDEGPARLFAGVMPALVLVINPILQYTVFEQLKQLLEKRRRVTPKDAFYLGALGKLLATSITYPYITVKSRMHVAGKDGPRESMMTTFRRIIREEGYTGLYGGIGPKVTQSVITAAFLFAFKDVLYAYMVQARKKLALRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6P9</accession>
    <name>R0K6P9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_154796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027667.1">
        <property type="nucleotide sequence ID" value="XM_008029476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6P9"/>
    <dbReference type="STRING" id="671987.R0K6P9"/>
    <dbReference type="GeneID" id="19397440"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="85"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="467" mass="53011" checksum="45302E58D6751B87" modified="2013-06-26" version="1">MGSESRHSSPARAGSQPVSEKDTDQHQPSMPFAASDDEKSHTDVPVDPNGVHHPSMVPDPDGKRELREWECWDKLAYSWPKWKKAMYLASIAGIQISMNFNTSVYPSAVNPVAEHFGISAQAARVGQMIYLVFYSFGCELWAPWSEEFGRWPILQLSMFLINIWEIPCSVAPNFGTIVVCRALGGLSTAGGSVTLGLIADMYEPETQHWPLCFIVLSSTIGTSIGGVIGGPIERYLTWQWNFWIQLIFGVVVQAVHFFMPESRATILIDREAKRRRETGEDPNVYGPNELKKPRISLKEAGKIWLRPFEMFIREPIVLLLSLLSGFSDALIFTFLEAFNVTFPNNFGFGTLEVAWAFIPINASYFFTYFLYWPWFWRDDHLRKKNGPDWMTPERRLKPLLLLALFEPIGLFGFAWTCMGPPQTHWIAPMIFSFLVGLANFAIYYSSVDYMRDEGQVLEEVAASAWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7S6</accession>
    <name>R0K7S6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_164522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028672.1">
        <property type="nucleotide sequence ID" value="XM_008030481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7S6"/>
    <dbReference type="STRING" id="671987.R0K7S6"/>
    <dbReference type="GeneID" id="19399159"/>
    <dbReference type="eggNOG" id="ENOG502S1PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_1_1_1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="147" mass="16344" checksum="8B8A460FA0AD9511" modified="2013-06-26" version="1">MAHLQHYCYPGFGEAKREELWYSQAVRVGDYIEIAGQGGWDPETSKIPTDLDEEIDQAFANVEHCLKHAGGKGWSQVYKIRLYLTDLSEQSVVACVRNFKKWLPDHRPILTCIGVNQLGLPGMRVEIECKAHDEEGAKAAAAAKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8A7</accession>
    <name>R0K8A7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_111413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908648">
        <property type="protein sequence ID" value="EOA85694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026650.1">
        <property type="nucleotide sequence ID" value="XM_008028459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8A7"/>
    <dbReference type="STRING" id="671987.R0K8A7"/>
    <dbReference type="GeneID" id="19395489"/>
    <dbReference type="eggNOG" id="ENOG502SI3C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539877_0_0_1"/>
    <dbReference type="OrthoDB" id="3792344at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57986" checksum="CCECB8C4FAACA4D5" modified="2013-06-26" version="1">MSSASNFDIISKLYHDVVQLYVLDGHTLNEVKGLVEKQEPNVNMTIAQWKSHLRAMRIHKNNSSAGSGLALTIMKEMGYGSDQCMVLSNGILLDMLEVERYRKRRKSLESSPGLCSPSQDLIFVPLSFKFSQISDLGYFKSFRRLLWFTSVHFDTCFDRGIWTTDERGVYCRSDVLKSGLSNLSRLHNMICAALEYMRRGHSSAGWIKIRAAFELLKAVVQTYHHRQLPDLLAIVLILHRADRSDLVRVLMEQLHGLAEIILQRNDPRKKVFQEISQLSMDAAGDLYVAFDACCRQLWMKKAAGDDKIKAYYGYNQASLPRTTSGGFYSLYDRKSGREIRDILQQVDQKFEPFEHPRICLWHTAIRYLIQEKELDEAKAVCNHLMASMLHCQEPSAQSQQRQWNVDISLTYYLLGSINEYHNLPSEAVRCFRFCVIERSKVIAEESWDPTLCAALNKIQDLAPRTSDFDLLDYSTRLLGAIESALAKEDMMRSELWHLQNVANNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8I2</accession>
    <name>R0K8I2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_127871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023085.1">
        <property type="nucleotide sequence ID" value="XM_008024894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8I2"/>
    <dbReference type="GeneID" id="19396031"/>
    <dbReference type="eggNOG" id="KOG3975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018394_3_0_1"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40300" checksum="3E1712F83D13E29F" modified="2013-06-26" version="1">MSSTPASLIHLRTPPEPGKKSASRTYIIYFVTGNPGLVEYYRTFLTHLYGLLSHNTASDRDVEFQVYARSLSGFEMNTAEIKTIKWRKQPPYGLQDQIRHAEDELTDLVEEVKEQGAKDVRVILMGHSVGAYISLEIIRRLRAHGLAGDDFETRVVGAIGLFPTIVDIARSESGMKAAPFLKNSNFAVFASLFVYFLTCLLPMSFIATLVAKFMGFPPDAANTTAAFIKSPHGIQQALHMARDEMFQIDTDIWDEEIWGASASEPPTKHPHPRPILRFLFARTDHWVADATRDALINSRGRFDAGEVDEADGLGENWKPIMDIDHREGWPHGFCIRHGVPVAEKVAGYVRSIVAQDMARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0K938</accession>
    <name>R0K938_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_163618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027332.1">
        <property type="nucleotide sequence ID" value="XM_008029141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K938"/>
    <dbReference type="STRING" id="671987.R0K938"/>
    <dbReference type="GeneID" id="19398823"/>
    <dbReference type="eggNOG" id="ENOG502QRMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_0_1_1"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45021" checksum="2A682A24C9BE1EAC" modified="2013-06-26" version="1">MGKEGIRYAAKVDLNKPASEQECLHNRWHPENPSYATIKPGEVVKIECVDWTGGQIGNNDSADDVRDVDLTKIHYLTGPFDIETAEAGDVLVVEIQDVQPLDEQPWGFTGIFAKENGGGFLDEIYPEPAKAIWDFEGIFCSSRHIPGVRFAGLIHPGILGCAPSAQVLETWNKREAELISTHTHLQRIVAEPPQPTNVHAGSAPAHLKAKIGQQGARTIPGRPEHGGNCDIKNLSRGSKVYLPVHVSGAKFSVGDLHFSQGDGEISFCGAIEMAGVITLKFSVMKDGMAQLGIKSPIYIPGPVEPQFGPGRYIYFEGFSVDEAGKQHYLDATVAYRQTCLRVIEYLRRFGYSDYQIYLLLSCAPVQGHVAGIVDIPNACTTMGVPMDIFDFDISPHVPAQKRDMGACAYVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9D5</accession>
    <name>R0K9D5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_161533</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026321.1">
        <property type="nucleotide sequence ID" value="XM_008028130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9D5"/>
    <dbReference type="STRING" id="671987.R0K9D5"/>
    <dbReference type="GeneID" id="19398162"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA86044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="567" mass="65368" checksum="041A16C5DA66B909" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA45</accession>
    <name>R0KA45_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_163808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027563.1">
        <property type="nucleotide sequence ID" value="XM_008029372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KA45"/>
    <dbReference type="STRING" id="671987.R0KA45"/>
    <dbReference type="GeneID" id="19398901"/>
    <dbReference type="eggNOG" id="ENOG502SR1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906178_0_0_1"/>
    <dbReference type="OrthoDB" id="4186058at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="306" mass="34792" checksum="977B276098333FC7" modified="2013-06-26" version="1">MTAHDQPPFAPLNGHLQSPPMTPSPEAHTRFPPPPHPTSPKYKRMGNCVQTPPLEFIEPTGFNHHFSFTRPQSCEPSSRPSSDSERAFAATTCESSDSEIELYDDDDDDNETDDESDGEEEIPLRRVDHAQFVLEELDSDPGYDCDVEILRPDHCEDARSDRGGVKAEISARMNELQLEEDSSEDEERVRKYRQKKKRWSAGIFKRSHSQSVEGDSSYSDNDPLDDLDQNSRRLRRRVRGPRRGSLIFEDQGVSNTNNILEVEEPEEGTVLHSKGPPSIPSDDGFTLDELPFWRAHVTMDFESDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAE4</accession>
    <name>R0KAE4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_177297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Han J."/>
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            <strain evidence="19">28A</strain>
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        <ligand>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
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    </reference>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
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                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Dhillon B."/>
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                <person name="Kosti I."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025165.1">
        <property type="nucleotide sequence ID" value="XM_008026974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDH4"/>
    <dbReference type="STRING" id="671987.R0KDH4"/>
    <dbReference type="GeneID" id="19405349"/>
    <dbReference type="eggNOG" id="KOG3315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073154_2_1_1"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA87419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23575" checksum="2ABEB36BC33530DF" modified="2013-06-26" version="1" fragment="single">MNGNPGQASGLRYPSNKKSIYDRNLNRSKNAELSRAAFAYLFIEMIAYAQKGAKDVGDLEQRLNSQGYPIGLRLLDLLLSRTANPLASIRPTRILPLLQFIAQQLYRYLFGRPADALEKSGTDPGQYMLFDNEPMVNQYISLPKELSSLNCAAFVAGIIEGVCDGAGFPTEGVTAHSVGEEEGKDGKGMWPGKTVFLIKFKPEVLEREEILGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDN0</accession>
    <name>R0KDN0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_110320</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026244.1">
        <property type="nucleotide sequence ID" value="XM_008028053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDN0"/>
    <dbReference type="STRING" id="671987.R0KDN0"/>
    <dbReference type="GeneID" id="19395416"/>
    <dbReference type="eggNOG" id="KOG3724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006103_0_0_1"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="845"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="894"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="963"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="14">
        <location>
            <begin position="99"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="15">
        <location>
            <begin position="690"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1011"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1011"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA86267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115707" checksum="151DC78D8538D680" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEA4</accession>
    <name>R0KEA4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_109586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024839.1">
        <property type="nucleotide sequence ID" value="XM_008026648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEA4"/>
    <dbReference type="STRING" id="671987.R0KEA4"/>
    <dbReference type="GeneID" id="19395372"/>
    <dbReference type="eggNOG" id="ENOG502S5QH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_1_1_1"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29922" checksum="96805FDD72879A20" modified="2013-06-26" version="1">MIEVVYIVRHAFRTSWSVDPQTGVYTASMARSPTGIPTDPPLTAKGVQQSKELAEHLAAIDPPIDRIYSSPFYRCLQTLKPFSDKVLSEGKAGGKIRVDRGIGEFFGRAHFEHPAPPTLEHLAPHFDNLDSDYVSLHVPGSNGESILELHQRVRKALEHIITTLDHEPHQPRTVLLCTHAATMIAAGRVLTGLMPENPDDDDFQCYTAGLSKFVRRSRDADKGVAGNWDCELNSDTSYLSGGAERGWRFNGEESFVDFSDTGMTGDVDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEJ3</accession>
    <name>R0KEJ3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_162800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025222.1">
        <property type="nucleotide sequence ID" value="XM_008027031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEJ3"/>
    <dbReference type="STRING" id="671987.R0KEJ3"/>
    <dbReference type="GeneID" id="19398542"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_12_0_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF385">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="222" mass="24083" checksum="325B78CEFF4911C8" modified="2013-06-26" version="1">MPHLPRASALSAFRAAPRFRAPVTKRFFTPSAYNMTIKAYFDCTWSGPTVEIDQAGTVTKTGEVAEQTGRINFELFDDVVPKTAENFRALCTGEKGFGYKGSKFHRVIPQFMLQGGDFTRGNGTGGKSIYGDKFADENFKLQHDRPFLLSMANAGPNTNGSQFFITTVVTSWLDGKHVVFGGVPEGDVESYKVVRAIEACGSPSGTIKNKNAPPTIVAAGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KH55</accession>
    <name>R0KH55_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_168422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023964.1">
        <property type="nucleotide sequence ID" value="XM_008025773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KH55"/>
    <dbReference type="STRING" id="671987.R0KH55"/>
    <dbReference type="GeneID" id="19400542"/>
    <dbReference type="eggNOG" id="ENOG502SBV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152072_0_0_1"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="101" mass="11174" checksum="7A51486C3CA2E07D" modified="2013-06-26" version="1">MSASSFAHHGKTPAAVSMRSSYKAYRSPFGPQYTIPKNYHGITVGTVARFGTLAAGFGGVAGFFALFFFAEVPRVREDIMKKVPILDKYFTYEIPPEDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KHG5</accession>
    <name>R0KHG5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_27453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023727.1">
        <property type="nucleotide sequence ID" value="XM_008025536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KHG5"/>
    <dbReference type="GeneID" id="19403129"/>
    <dbReference type="eggNOG" id="ENOG502S764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107661_0_0_1"/>
    <dbReference type="OrthoDB" id="2555434at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15398" checksum="47B3C2AE46883DF4" modified="2013-06-26" version="1">MFEGRHAADRYRLHLHRARSVVLTSDELVEIRAAQRTFEGAYVRTAIGQFSFALVVLKIFTAEFYSIGALFAVYGAGILFTSLFRRQQGNKQFFSEVGSDGLHRKKFRTSGNVVFVLTALSVSAYICLLVLTLKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KK31</accession>
    <name>R0KK31_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_167965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023270.1">
        <property type="nucleotide sequence ID" value="XM_008025079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KK31"/>
    <dbReference type="STRING" id="671987.R0KK31"/>
    <dbReference type="GeneID" id="19400375"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="190" mass="21534" checksum="6694B98056E072EE" modified="2013-06-26" version="1">MPAYHSVFLDEPNQQLIGNFALLPLRTRTRGPAVQLPALPADVTELTIDASHDSYDPLDEVLALFRANTFFRNFEIKGPADRVLIYGILYVSEVLGKIKPSMSRREAEKAVMNSALDTNFAIPGDAGFPLNQAFEPPPDRNSAEVLRQYIMQMRQELATRLLNRVYADETNTPSKWWLSYTKRKFMGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KME2</accession>
    <name>R0KME2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_126238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022169.1">
        <property type="nucleotide sequence ID" value="XM_008023978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KME2"/>
    <dbReference type="STRING" id="671987.R0KME2"/>
    <dbReference type="GeneID" id="19395984"/>
    <dbReference type="eggNOG" id="KOG0171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_3_1"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000015">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="40"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA90289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="210" mass="23181" checksum="1EB734400214E73A" modified="2013-06-26" version="1">MPPPWSFIHRFHRQSAPAILNPKTWTQNTILVGKFFFVGHIVFTYIGGVGSTSGISMVPTIPHSFGSHPWIVYSTLHRRGRGIQVGDVVTFTHPLFPQDSSCKRVVGMPGDFVSVVTPGRTDADVDAVDGEGKWASVREEVVRVPEGHCWVQGDNLEWSRDSRLFGPLPLGLVRSKVLAVILPFSEAKWVGSKVDVVEAQGGERDWVVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNB7</accession>
    <name>R0KNB7_EXST2</name>
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        <recommendedName>
            <fullName evidence="8">YTP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_37924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022929.1">
        <property type="nucleotide sequence ID" value="XM_008024738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNB7"/>
    <dbReference type="STRING" id="671987.R0KNB7"/>
    <dbReference type="GeneID" id="19404306"/>
    <dbReference type="eggNOG" id="ENOG502QRB1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034579_1_0_1"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354299" description="YTP1" evidence="3">
        <location>
            <begin position="22"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="157"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA89412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51967" checksum="C741C6FC18E4D131" modified="2013-06-26" version="1">MHLLTRSAAFVALLCSSPAMAHIHAVNKIQEGEAISQDPIDSVLWTHMLIQGLAWGIIFPTGMVLGIIRSKWHVPVQSVGTVLAIIGYFLGHKHGGRQFSPDNIHSTFVPVIMLMLLSQIVMGIYLKLHLEKGINGKIRNIIVKVHGVVGKALPVVTWVQFLFGGITALGFCREDHTGQCLAHFIMGSAFIAYGIILLILLLVGQMWLRRTGKSQEFFDSLVIAAWGCVNTFTEHRWGGPWVHNDLQHTSMGIVWWAAGLVGIWLSRKRNGQPKRNLIPGIVILMTGWAMSAHPQHLPLSAMIHTVFGYTLMAAGAARIIEISFVLKDRTSIHTDGSDPNSFQYMTPFLLIAGGFMFMGATEEQMQLLSDANVTHVSYVLILFSIAFVLFLFVNVLIHLYAVYAWEQDDKADDEAPHVNGHANGYTRVDRRIRDAEEFELEGLDSDDDDNDTQLRHKESRTHAARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPK2</accession>
    <name>R0KPK2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_159355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022712.1">
        <property type="nucleotide sequence ID" value="XM_008024521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPK2"/>
    <dbReference type="GeneID" id="19397927"/>
    <dbReference type="eggNOG" id="ENOG502S1U0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068908_0_0_1"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="188"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA89782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33795" checksum="F5FB3534F6D06585" modified="2013-06-26" version="1">MDALTPSDLFSPSKARQQRAQAHDWAQIDLWLSYKYAGRTVPTFERNDDTLKALRELSVANERADEERAVMERVEREALRELDEVQSNEHDERILSQLRASLTPEGEQALDALASTAVALNTPTANPESIAHALIYNTTTSQNLTNQLAHIAALQGYVDKQQSLLRTQLHDIQTNPAFSTPPTLQRQTTEQTRQIKHLRTKIREYEDKLSSVQSSQSRNMTPGSKNIGSAEAINDMLEQQKALDELRERVEAVEREVREFAGLPADKEAARKEVGKLEVRLDEVRRRRDELFEGLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQZ0</accession>
    <name>R0KQZ0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_170348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020648.1">
        <property type="nucleotide sequence ID" value="XM_008022457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQZ0"/>
    <dbReference type="STRING" id="671987.R0KQZ0"/>
    <dbReference type="GeneID" id="19401035"/>
    <dbReference type="eggNOG" id="ENOG502S04V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041456_2_1_1"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="38"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="256" mass="28594" checksum="57BB3DB520DC39D6" modified="2013-06-26" version="1">MATTASTLPQGFLEGPAPNLTKTKIDFAKGGIPECEKSWAVVLDGVLTEEECETLVRAAEATTDGKWERAMVNVGGGLQAMYEDTRKCGRIIWDNKDIMAKIWARVESSVPEIHTLQNWAEVTGNGPVKRGETWVVTRLNERGRYLKYTGGEYFKPHCDGAYETPDRTERSYFTLHLYLSDAFGKDGTKQLEGGATTFFNGSMTRRIDVTPKIGRVLLFQHCLLIHSGGDVVSGTKYTLRTDIMYALKENVEKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRN9</accession>
    <name>R0KRN9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_178115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
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            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
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        <property type="protein sequence ID" value="EOA91649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="reaction ID" value="UER00003"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
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        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="354" mass="37765" checksum="3BDF65E7ED753D99" modified="2013-06-26" version="1">MSRALLTTTTTTLRASARLTPRIYSSVKTPIPTPICTAAPPSPSQTRWSSHSPLGTTPAHARKPVTITTLHSMHRKGEPITMVTAHDFPSAHVADHAGMDMILVGDSLAMVALGMEDTSEVLLEEMLLHCKSVSRATKTAFTVGDLPMGSYEISPAQALSSSILMLKTGRVKAVKLEGGAEMAPTISTITRAGIPVLAHIGLTPQRQNSLGGFRVQAKSAGSALKLLRDARAVQDAGAFAVVLEAVPAEVAGLVTAELKIPTIGIGAGNACSGQVLVQVDMLGNFPPGRFLPKFVKQYGNVWAEAQRALELYRDEVKSRVYPAKEHTYPMAKEAFDEFKAVVEEEEERGKSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020457.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSU5"/>
    <dbReference type="GeneID" id="19405579"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011715_0_0_1"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="567"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA92034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="886" mass="96137" checksum="A27ACBB0CA586468" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KT17</accession>
    <name>R0KT17_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_134145</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="166" mass="17019" checksum="A7C0D0FEA53DB22E" modified="2013-06-26" version="1">MRFSTAVAITLSASASLVAAQNKCDAQNIVDTCVQGYKSRIDGCNQKPNDFICLCDVYRDVLVCYNNCPNSLDKPPVENTVTSYCNAAEPLRAAASSSMASVASVAATQSHAAATKTSAESTPTGTGTTTDKSPSPTASSFKSTGNQNGVQVGAAVMALLGAARLL</sequence>
</entry>
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    <accession>R0KVM4</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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    </evidence>
    <sequence length="72" mass="8025" checksum="1EF4F97B4729EE56" modified="2013-06-26" version="1">MPGAIYCAVAISLPTCARPRYTKYLLLRLAKASPRKRNPISLLRGVRARPRHLGFLVRLLPAAVCLCLPSWP</sequence>
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    <accession>R0KWS1</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">28A</strain>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="310"/>
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        <location>
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        <location>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA92127.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1064" mass="120273" checksum="5D287B6BC2818127" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KWV5</accession>
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        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_134260</name>
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    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="671987.R0KWV5"/>
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    <dbReference type="eggNOG" id="ENOG502S18D">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_RING_CS"/>
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        <property type="match status" value="1"/>
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        <location>
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            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA92167.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="551" mass="61320" checksum="776E324D6DBE9ED9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>R0KXA0</accession>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_134587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">28A</strain>
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            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
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        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA81051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031303.1">
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0I6A4"/>
    <dbReference type="GeneID" id="19404955"/>
    <dbReference type="HOGENOM" id="CLU_064325_0_0_1"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
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    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004352740" description="CFEM domain-containing protein" evidence="12">
        <location>
            <begin position="31"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="13">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA81051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="388" mass="41757" checksum="17AE5B86B9633510" modified="2013-06-26" version="1">MRLSALFPWTIQRLGIFILVFGALIQQACTVPHGVHVRQTPLSLLKLPDCALRCFVNHVVADNCAVITDFACHCGDESLFDSYSSCIAQRCDQSLRENAMTALREDCGSSLNTNDVTKANGTTPVDASPRIGTRNATSTGTSQLSSMTTNEAEPAQSSELRSSTLITSTSSQQLSVVVQTTIVSITTTETSRATLSPAQPTSTETEVQISPIAQSTELSHAARAGIGVSVAVVASVVTVGLGWYICRLKRQLHAAQEVIIARTDLMDRHDAAVPLPPPPTARTRQCVRSWLSTNAEPVSPISAHPRPMEDGPTTISNIGYGMVLKKRGEILSILIEREGEGDEYAERVVREPVPGQREGLTSPLELDGIATGLFEMPAVVTPRRSIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0I701</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_44298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I701"/>
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    <dbReference type="HOGENOM" id="CLU_1027266_0_0_1"/>
    <dbReference type="OrthoDB" id="3936754at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343390" evidence="2">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA81355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="301" mass="33094" checksum="F23CA2DEA20BCF18" modified="2013-06-26" version="1">MLSNTLAASLLLLTPSALAAPTRTHCSCKIVYNDTTSTSPPPSLYTPSTAHWTPGNPSEDESKSPLPAPIAVSVAVCASLGSELERFRHTEPELYDLYMGEEQRRKQEETSTTERRPLPTAVLLRGDQDIINPGHNSHKHHDDHTSRPSKPQGRIVCFASPGTLPPHDYQTSSMGLCALQLIVVLSIFACIVEGLQLCRNFIKQQFFSSSAPENDPLPPSGSLRLNGAEKRLLAIPETHPTDPRYPLCSSPGAEKKMRAYENSSHLSISPTKYFVHHGVGGRREFIAYDDDSDDEVNRPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8F3</accession>
    <name>R0I8F3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_166052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031064.1">
        <property type="nucleotide sequence ID" value="XM_008032873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8F3"/>
    <dbReference type="GeneID" id="19399683"/>
    <dbReference type="HOGENOM" id="CLU_2943286_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA81666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="60" mass="6693" checksum="95B71EACC214464F" modified="2013-06-26" version="1">MACTRHAPRPGKPPSLRSPFAGCLPWAALLCRHPTLSLSQETLVVERYVHVQRTRLAVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8K4</accession>
    <name>R0I8K4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_99548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="50840" checksum="E2F5B800F5A6F9B2" modified="2013-06-26" version="1">MAKITDLSNELLINITSYLSTGDEYAVKTLLYLCRTSRVLLGVAQPALYTSVRIVESTTDPLIHLKLFLRTVIECPSLAQKTKELALFNDHGILARLPNLRHLHLTTQIEAPRSLMQRMHEMQADLSILSKLKTFHLHKQYEDGPVDIEDYIPLMQYPSFERFSSESDVPDTPHGSRATNVITHTNAELSWCIRPLSTMEKLLDACPHLTVFKLDIPSETRYRWLWDVGYDPLVTPRDLVQALLRTHRQKLQTLYLNYGSNYNLNDPELQEEIEMSGDSVLDYPSYHIFTYPSFRDFETLSRITIEFERLYQFQDLPASLEHLQIICCHFEDLNRARLSNLIRLKDKWCPVIQSVTVCDYEEINQGINIVRDHATSLGMSVRVSAYGRVLTILGAGYHLTVKNLAYPMLDVSTHEDVMDISNLKMLLLWIQSRVQVVDLIN</sequence>
</entry>
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            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="19404902"/>
    <dbReference type="eggNOG" id="KOG2841">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ERCC1-like_central_dom"/>
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        <property type="entry name" value="Restrct_endonuc-II-like"/>
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        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        <location>
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            <end position="355"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <begin position="1"/>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA82200.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="355" mass="39200" checksum="71372815A29DCBE2" modified="2013-06-26" version="1">MDNAPPRPPRPPASPPKVAQPKPQALPSRSGPSSILVSPRQKGNPILSSVRAVAWEYSDIPADYVVGATTCALFLSLKYHRLHPEYIYNRIRDLKGQYTLRILLTMVDIENHEDPLRELSKTSLVNNVTVMLCWSAQEAGRYLELFKTFENAAPTSIRAQQAGTYSESMVDFITVPRSINKTDAVGLVSNFGSIRTAINASPEEIGLIAGWGDKKVQRWCNAVREPFRVQKAARRGLVEESRNMPVAEGEDQAPTATHAGDTAHQRVDDAIPLAKELERSAPFAPSGSDADKRPEHRPAEYLNEDDEQAMREAEMSGDLEANSAQSPLAKPAKRKQPDEQISEGVMAALNELRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG0013">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
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    </feature>
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            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="295" mass="32234" checksum="B87997C1A492FB76" modified="2013-06-26" version="1">MGCCASRPTDDGTPAVRAHSSSSRNITAPSTRRAPTTSPRASHVSQPNAPPSRSRSEVIERPNTALKPIPPAQRSRLPTTLASSASKTSSRIKPLTDPTSLTWTRARLQKERDDWWDTQVTGSEEIWGAIRLAAQHLQAGQLQEAQTMLDVTGCTCPTGLFWRGVYDPTGVQYKVPEWVVVEPDGLVEDHVDDKMLAGPVAASPDAQDDDDDGPDELASVRVRTSHDSKDVILDIHKKDSVAVIIGKLKEAAQINASARVRLAYGGRVYHDYEVLEAQPHWNFANGFVLNALVFQ</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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            <begin position="293"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="397" mass="43165" checksum="2B808BC803B01A37" modified="2013-06-26" version="1">MHSRLVFLTAAAASLSFVRSEDICYSYGVDFVDEGSYFINSESTDDFTAVSYFKGCNQDMADVLLVAPEDTPGETEFLCERIPTTPDNQNQMSTCPIKKNQMSSGHWLLLVLGNNGKGGQPFAWQRDLYLTVGPQITTTYTPTLTMSITTTPTITEMTTTTFTDVITTGPFSTVTMPSGTAKKIKTVTPKAVTTTSTKTMTRTKVSTTKVTGYTTKTVTATCTTPEHTGKPDKPCEYSPTKLHPAALVTPTSIPKWRRFSPRSDREVDYEWARARVEAAKQRRAEALQRRTPDAPTVTVTYDTPVPTTTTLTADATTTTETVLESTTSTSTIPAPTVLSGILTMTTTLPTPTKTKLKLGYATTTKVITFGATYTKTTTVTPPASITACKKNGGHYWS</sequence>
</entry>
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    <accession>R0IAU3</accession>
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            <fullName evidence="4">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
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        <name evidence="2" type="ORF">SETTUDRAFT_165044</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031458.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38298" checksum="4A78F7E4398C9BD9" modified="2013-06-26" version="1">MKSTDPVRPSSRRAASGAWNRLKPVREDILETYGLPSKGETRLNDFKTQEVYFNRITERYMKLCALNREELDRLFASVSIPPAAPADSKSSDATSKLTSSFSSLSLSKHAPPEYQNTRPPPLTTTSTSASAPASTHSIPQKAFAPSIQELATVLASLRKLREAITASSRSDAFALRAYTFAIHVSVLCHDWASYLPSLLSLLNTIHPRNPLPPSTLHEFVGLLILDQACRQSDFAGARQTKLQYGYKDWRVETVLKCLVADDFVGFWRVRRAVDGYQRSVMEWADGGVRVHALKCLGKAYLSADRAFVERVTERRWEELVQEGVGWELSADGERVIIKKPKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICI2</accession>
    <name>R0ICI2_EXST2</name>
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        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
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    <organism evidence="8 9">
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031319.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0ICI2"/>
    <dbReference type="GeneID" id="19404869"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA82911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="460" mass="50736" checksum="A79D1BF1F964E837" modified="2013-06-26" version="1">MAARPSNIGIKAIELYFPSQCVDQAELEKFDGVSQGKYTIGLGQTKMSFCDDREDIYSLALTTVSSLFKKYNVDPKTIGRLEVGTETLLDKSKSVKSVLMQLFEESGNYNVEGVDTVNACYGGTNALFNSINWVESSGWDGRDAVVVAGDIALYSKGAARPTGGAGCVAMLIGPNAPIVMDAGQRGSYIRHTYDFYKPDLTSEYPIVDGHFSLRCYTEAVDACYKAYNEREKTLKSQQNGNGVNGSSHQIETAVDRFDYMAFHAPTCKLVAKSYARLLYNDYLVDPSNPIFAEVPAELRDLDYATSVTDKTVEKTFMTLAKKRFAARVQPSIQVPTQCGNMYCGSVYGSLCSLLANVNSQDLQGKRIGMFSYGSGLASSLFSFTVKGSTESIAKHLDIQNRLESRRVVAPQVYDDMCHLREQAHLQKDFTPKGNPDTIVPGTYYLTGVDSMFRRTYAIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICI8</accession>
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        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_94405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028905.1">
        <property type="nucleotide sequence ID" value="XM_008030714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ICI8"/>
    <dbReference type="STRING" id="671987.R0ICI8"/>
    <dbReference type="GeneID" id="19406103"/>
    <dbReference type="eggNOG" id="ENOG502QRU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010014_4_0_1"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
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        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="251"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="621" mass="70559" checksum="AC4EF9225F298DA1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGA0</accession>
    <name>R0IGA0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_172593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA84046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028462.1">
        <property type="nucleotide sequence ID" value="XM_008030271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGA0"/>
    <dbReference type="STRING" id="671987.R0IGA0"/>
    <dbReference type="GeneID" id="19401192"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
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        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
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    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="208"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA84046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="373" mass="41554" checksum="A26C8F84BF7CA203" modified="2013-06-26" version="1">MAPSIPEPDQTTYDEARNGAAAYLQSRLSAKDNDVNENFMIPFIDLTPSFSKSPADRQRVASQIRKACTTSGFFYITNHGVPKSACDGILHQAERFVTQLPLEKKEALHLKNNKFGLGWEPSEYTSIAGDKEEKEVFNFAYEAELDPTGGDGKYKNLDGSTGKSNMWPSLEDLPGFYDGVKEYYGSVLNLARHLFRLFALSLDLPEDYFDSMTTHPGGIARLLYYPPPKHPISPNTVSTSDEKIGLGAHSDYECFTLLLTSTTPGLEILKPSGQWHIASYIPGALIVNVADFLMRWTNGLYKSTVHRVVNRSAAPRYSVPFFFSVNYDTVIETLPTCLKDGEESKWRPIRAGEAQCYDGVWGRVPTGHQRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0IH18</accession>
    <name>R0IH18_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_92929</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028627.1">
        <property type="nucleotide sequence ID" value="XM_008030436.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IH18"/>
    <dbReference type="GeneID" id="19406002"/>
    <dbReference type="eggNOG" id="KOG1246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000991_2_2_1"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15519">
        <property type="entry name" value="PHD1_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15518">
        <property type="entry name" value="PHD_Ecm5p_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000010">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000014">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000322">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="12">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="11">
        <location>
            <begin position="148"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="467"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="609"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1336"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Lindquist E.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA84915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="286" mass="31851" checksum="6705991F6534AB43" modified="2013-06-26" version="1">MDDILNEQFGRVEKALTTLVDSIAAYNPATQAAIDLVAADDQLSEGLDQLAKHQANHARIQTLRAEADALEEQLKTSVKKLAELRRELFATPATTFPHDSRAVPFDELLQYATNISRYTVPPTYRERVPTTEKDKDEEDGISSGAPTNGVNTPAIVPDAPDAPNEGPEAQKGAEDADGAAPDITAEEEEWLKKLKASNLAWYPWPSTEKIRNGILYRLSYWREKGNDLDEFNIPAYLEEQRKKALGDEEKSEEAPEQATEEQPHRETARPTMPLSAFTGLDDMDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIL0</accession>
    <name>R0IIL0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_136838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027323.1">
        <property type="nucleotide sequence ID" value="XM_008029132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIL0"/>
    <dbReference type="STRING" id="671987.R0IIL0"/>
    <dbReference type="GeneID" id="19396383"/>
    <dbReference type="eggNOG" id="KOG0278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_6_1"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="317" mass="34630" checksum="AC89C01F4A4E284C" modified="2013-06-26" version="1">MPETTKVVPLTCHGHSRPVPHIHFSSLVDEDQYYIISACKDNNPMLRDGITGDWIGTFLGHKGAVWQARLSSNASLAATASADFSAKVWDTHTGEALHTLAHNHIVRAVAFPNQPHPQILATGGMEKKLRIYDLSRSDATSFEIGAGVHTGTIKSIVWTSDPNIIVTAAEDKKIRWWDLRQEATIGEHAVEGTVGSCELDNTSSDGILSVAAGNSAYFFNSLSPGSLIKSVKTPYELASVALHNGERKFVTGGSNQNDTWVRVWDFDEEKELETNKGHHGPIWSASFSPDGKLYATGSEDGTVKLWKFTTGPYGLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIX1</accession>
    <name>R0IIX1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_163693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027411.1">
        <property type="nucleotide sequence ID" value="XM_008029220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIX1"/>
    <dbReference type="STRING" id="671987.R0IIX1"/>
    <dbReference type="GeneID" id="19398852"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="503"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA84891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="540" mass="58762" checksum="E5A586F1F71E6B19" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJ60</accession>
    <name>R0IJ60_EXST2</name>
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        <recommendedName>
            <fullName evidence="10">Ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_163747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA84981.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJ60"/>
    <dbReference type="STRING" id="671987.R0IJ60"/>
    <dbReference type="GeneID" id="19398875"/>
    <dbReference type="eggNOG" id="KOG3257">
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    <dbReference type="HOGENOM" id="CLU_074237_1_0_1"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR006519">
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18285" checksum="520583C9C97D7C5F" modified="2013-06-26" version="1">MARKAIAKDQIVKLIVGAGQASPSPPVGPALGSKGVKSMDFCKEFNARTAHYTAGTPIPARITVRPDRSFHFQIRTPPTATLLLSAAGVLPTKNKIRGAGNVPGPMNNHEGQKGKTSTSSPTVGNAVKGTVGTVSLKHVYEIAKIKQSETRLSGLSLEGIARSVVGQAGSLGVVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IK99</accession>
    <name>R0IK99_EXST2</name>
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        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_65325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027113.1">
        <property type="nucleotide sequence ID" value="XM_008028922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IK99"/>
    <dbReference type="GeneID" id="19405315"/>
    <dbReference type="eggNOG" id="ENOG502QS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_0_0_1"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="45"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA85296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="296" mass="32224" checksum="2C4283B4B9F6584B" modified="2013-06-26" version="1" fragment="single">NTTFNPLHGIQPFPLSSYSTNMTRRAPVIALSHGGGPMPLLGDPSHAPITKSLQTRVPHILKLGTPDAPKAVVLVTAHWSTDKVTISSGAAHELLYDYYGFPPESYHIKHNAPGSPEVAEQVARALDEAGIEHVKDPQRPWDHGVFVPMKLIDPSATTPIVQVSVLASESAAQSYAVGRALAALRAQNIAIIGSGFATFHNLRLFSQLANPALQAQTKEWSRAVTDAALTDDDAQREHKFLHWRSWQHAYSMHPRGGAEHFLPLIVCAGAAAATKGKAYADSLRGTDMWSYYWDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILJ5</accession>
    <name>R0ILJ5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_110964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026494.1">
        <property type="nucleotide sequence ID" value="XM_008028303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILJ5"/>
    <dbReference type="STRING" id="671987.R0ILJ5"/>
    <dbReference type="GeneID" id="19395461"/>
    <dbReference type="eggNOG" id="ENOG502SAX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353064" description="Nephrocystin 3-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="207"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA85940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="440" mass="49550" checksum="60FEB31427608A6C" modified="2013-06-26" version="1">MDPLSVTASIIAVLQLSAKVLVYLNDVKDAPKGRTQCAIEISNLHSLLYRLKDHVENGDFRQSWHLAVQDLAIKNGPIDQFKQALETLQSKITDGRRLQKVGEALVWGFKKEEVAGILDRIEHLKSLVEIALQMDHLAISLTYSSKVSQAIKDDTNFIRMHVPVIQSGVDEIRQDQDATKHRRILEWISPTDYPAQQSDIIKRRQEGTGQWFLDAPQVATWLSEPRAILFCPGIPGAGKTMVAAIAIDSLLKSVQSSSHGVAYVYCNYKAQEEQDTSRMLAAILKQLVQARPSLVEPVERLHEKHAGRGTRPSPDEVFSALRDVLAHYSTIHIVIDALDECRDSDGTWRQFLAKLRDLQAGRDVRLMATSRLIPEIVDWFNEGLKLEVQASEEDVKRFVAGQIYRLPKCIQRDPALQEVVQEKIVEAVDGMYVRPSQLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILY8</accession>
    <name>R0ILY8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_184978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908637">
        <property type="protein sequence ID" value="EOA85836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026619.1">
        <property type="nucleotide sequence ID" value="XM_008028428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILY8"/>
    <dbReference type="STRING" id="671987.R0ILY8"/>
    <dbReference type="GeneID" id="19402077"/>
    <dbReference type="eggNOG" id="KOG0315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wang R."/>
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                <person name="Han J."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908593">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="110" mass="11988" checksum="25CB6B2D26CA44DB" modified="2013-06-26" version="1">MAARMQVRIGGPSKSEVEAVAQQNVGSQGCANIDSRFNGTRKARMWLRDQHKEKRCGTEALYNADPVSCMMSADTDAASTSDKAAPTAWRSRAFALSIPRPVQRTVCVDI</sequence>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IP12</accession>
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    <organism evidence="8 9">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
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    </dbReference>
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        </location>
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        <location>
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            <end position="541"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="566" mass="65363" checksum="D79E5806B75502E3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0IUX8</accession>
    <name>R0IUX8_EXST2</name>
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            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
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    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
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        <property type="entry name" value="Proteasome_alpha"/>
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        <property type="entry name" value="Proteasome_alpha-type"/>
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        <property type="entry name" value="Proteasome_alpha_type_5"/>
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    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
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    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA88580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="245" mass="26779" checksum="876C35DDCE15FDBE" modified="2013-06-26" version="1">MFIARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATGEGVILGVEKRVTSTLLETSSVEKIVEIDRHIGCAMSGLQADARSMIEHARVESQNHAFNYAEPLRVESCTQAICDLALRFGEGAEGEESIMSRPFGVALLIAGYDEDGPSLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEFHKSLTLAEAEVLTLKTLKQVMEEKLDSKNVQLASVTKDKGFRIYTDEEMAEVVGRLPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVA0</accession>
    <name>R0IVA0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_167966</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023388.1">
        <property type="nucleotide sequence ID" value="XM_008025197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVA0"/>
    <dbReference type="STRING" id="671987.R0IVA0"/>
    <dbReference type="GeneID" id="19400376"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="192"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA88690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="363" mass="39074" checksum="86074641443A1FF4" modified="2013-06-26" version="1">MTSPAEFNGWLGLDKTAAQGNMKWSSFKPKPFTDIDVDIKISHCGICGSDIHTLRSGWGSTHYPTCVGHEIVGHVVRVGDKVTKLALGDRVGVGAQAFSCLKDDCEECRAGLEQYCTRTVNTYNSKYPDGSWSMGGYADHVRVPAHFAIKIPAALKSEDAAPMMCGGITVYSPLKTNGAGPGKKVGIVGVGGLGHFGILFAKALGCDKVVAISRKRNKVQDAKAMGATDYIATAEDDKWARKHSRSLDLIISTVSSPDMPLESYLRLLRTGGSFIQVGAPEDKLPQISAFGLIGKGCKIGGSSVGSPGDIEEMLNFAAEKGIKPWVQKRNMKDANKCIVDMEEGHARYRYVLVNTDNADRARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IY72</accession>
    <name>R0IY72_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_103912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022652.1">
        <property type="nucleotide sequence ID" value="XM_008024461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IY72"/>
    <dbReference type="STRING" id="671987.R0IY72"/>
    <dbReference type="GeneID" id="19395017"/>
    <dbReference type="eggNOG" id="ENOG502QSRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030125_1_0_1"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="51"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="426" mass="47690" checksum="A77EBC29ED7DB937" modified="2013-06-26" version="1">MPSAIVTGATGILGREIVSELSQHRQQWPTIHALSRSKKEDYSDNVIHNHIDLQSDPDSMASDLKNVRGEYIFFAAYLAQDKEEDAWEVNGRMLSNFLCALEKTGVITEVKRIILVCGAKQYGVHLGLPKLPMHEDAPWLTSSEWPPNFYYNQQNILHDFCTKHNKEWVVTYPNDVIGFAMGNFMNLSAALALYVLVSKEMSSGSGIEFPGSPTFYTHFDCFTSSKLHAEFCAWAALEPRAANQAFNVVNGDVESWQNLWPKVTAYFGISVKPDQFKNAFGTSNSTGSMTEKIMEKVVGTNTPASSTMDMAPRPPISLQADAIGVEGTPVLHPNKVEQHIDLVQWSQRADVQQAWHALAEREGLDKTAFDKATWSFLGFVLGRNFDLVISMSKARECGWMGYSDTWASLKHVFEQMEDARVLPRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYN7</accession>
    <name>R0IYN7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_104033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
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            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA91256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1246" mass="143080" checksum="7B53AC63A67E9E8C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0J445</accession>
    <name>R0J445_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_152771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020803.1">
        <property type="nucleotide sequence ID" value="XM_008022612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J445"/>
    <dbReference type="STRING" id="671987.R0J445"/>
    <dbReference type="GeneID" id="19397223"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYROSINASE"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TYROSINASE_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342600" description="Tyrosinase copper-binding domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA91705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="344" mass="37420" checksum="698A9BF12C4B5E9F" modified="2013-06-26" version="1">MRFNSLALLITAGTLSSALPAPQNDATLPTEPSSDPAVANEQIKQLALFAQQQVNATLEASSAKRGTCNINNVAIRREWNALSKKERKAYTDAVLCLQSKPAKTPSSIAAGAKSRFDDFVVNHIQNTLFIHFTGTFLAWHRYFTWQYEQALRNECGYKGYQPYWDWPKTAESGLDNSPMLDGSEYSMSGNGEFIPGQGEVVIAGTGPPEIRLPPGTGGGCIKSGPFKDMKVNLGPTSLTLTNGSTISNGDGLAYNPRCLKRDLTDYANKKWADAPSVASLILKNNDVWNFQMTMQGWPGTPDLGVHGGGHYSMGGDPGRDFFVSPGDPLFYLHHAQIDHAETKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0J524</accession>
    <name>R0J524_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_134018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020991.1">
        <property type="nucleotide sequence ID" value="XM_008022800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J524"/>
    <dbReference type="STRING" id="671987.R0J524"/>
    <dbReference type="GeneID" id="19396231"/>
    <dbReference type="eggNOG" id="ENOG502QQ2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010539_2_0_1"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA92015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="78157" checksum="EE6CC03A66958B2C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0J670</accession>
    <name>R0J670_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_41001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020306.1">
        <property type="nucleotide sequence ID" value="XM_008022115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J670"/>
    <dbReference type="STRING" id="671987.R0J670"/>
    <dbReference type="GeneID" id="19404664"/>
    <dbReference type="eggNOG" id="ENOG502TJEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017128_0_0_1"/>
    <dbReference type="OrthoDB" id="5431456at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA92181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65159" checksum="7CD4545F0B58E2AA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JIK3</accession>
    <name>R0JIK3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_100475</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031668.1">
        <property type="nucleotide sequence ID" value="XM_008033477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JIK3"/>
    <dbReference type="STRING" id="671987.R0JIK3"/>
    <dbReference type="GeneID" id="19394798"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_1_1_1"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="15"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA81158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="450" mass="50841" checksum="52BF8297BFB7D634" modified="2013-06-26" version="1">MASGSTSSNVVGVHYRVGKKIGEGSFGVIFEGTNLLNQQQVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCNRKFSIKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGTKSANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTPIKDLCDGFPEEFNKYLSYVRNLGFEDTPDYDYLRELFTQALKSTGEVEDGEYDWMKLNNGKGWEVMKSHPSAAQAMHHSNVNPNSSMAVNHQGQQHRQQKTHLPIDHHRLNEPLPKPGATRAQPGRSPRENMNRDSQIKRKSMGELAPPEGASTQAQFQHSQPNLSQNRAAPASSPTPQQPRQQTPEKPSFMQKLASALCCGASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJB1</accession>
    <name>R0JJB1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_98330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030897.1">
        <property type="nucleotide sequence ID" value="XM_008032706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JJB1"/>
    <dbReference type="STRING" id="671987.R0JJB1"/>
    <dbReference type="GeneID" id="19406364"/>
    <dbReference type="eggNOG" id="KOG0526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017374_3_0_1"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="377"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA81428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="566" mass="63161" checksum="1B03CEB89BBB68BB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0JMQ0</accession>
    <name>R0JMQ0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_140637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029623.1">
        <property type="nucleotide sequence ID" value="XM_008031432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JMQ0"/>
    <dbReference type="STRING" id="671987.R0JMQ0"/>
    <dbReference type="GeneID" id="19396569"/>
    <dbReference type="eggNOG" id="ENOG502SKSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007381_0_0_1"/>
    <dbReference type="OrthoDB" id="5341924at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="114" mass="11896" checksum="D00F9AC761E27BC1" modified="2013-06-26" version="1">MAPGPKRKNTTKHLSLFACDAGGRGRGRGRGRGRGRGPCSTSMGPCRQPLDARGDRVMGAASPASCGHHSYPPSIHPSTHPPIHPTLHSPPPTHAHAHAHAPSHTPAPLPFNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXD2</accession>
    <name>R0JXD2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_100776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031515.1">
        <property type="nucleotide sequence ID" value="XM_008033324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXD2"/>
    <dbReference type="STRING" id="671987.R0JXD2"/>
    <dbReference type="GeneID" id="19394811"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_1_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006529582" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA80932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="210" mass="22820" checksum="4596FAD2A40D74E4" modified="2013-06-26" version="1">MATFQRAVVSLLLILSITFVFFAQASEATKGPKITHKVYFDIKHGDEDLGRIVMGLYGKTVPKTAENFRALATGEKGFGYQGSGFHRIINAFMIQGGDFTKGDGKCTGGKSIYGEKFPDENFKLKHSRKGLLSMANAGKDTNGSQFFITTVITSWLDGRHVVFGEVLEGYDVVEKIEGVEKGPGDKPKKPVTIAKSGELEVPAEGIHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXN2</accession>
    <name>R0JXN2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_165678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030510.1">
        <property type="nucleotide sequence ID" value="XM_008032319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXN2"/>
    <dbReference type="STRING" id="671987.R0JXN2"/>
    <dbReference type="GeneID" id="19399549"/>
    <dbReference type="eggNOG" id="ENOG502SCTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122140_0_1_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13366" checksum="015AC3641CD7ED97" modified="2013-06-26" version="1">MSMPNEALQKVLQEISQKKAFAEQQLAIVKQQKAARARESRMLQLTSSEVSSLPEDTKVYEGVGKMFVCTPIPDVQKRLKEESEALTKEMANLDKKEDYLEKTYANSKSSLEQVLKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXU3</accession>
    <name>R0JXU3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_169641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="67"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="168" mass="18593" checksum="0F55766B051ED617" modified="2013-06-26" version="1">MDFRCKRCEEKNLRCFVKTTSSRCASCISVAAKCKVQRARREKELEIARAEERQALAMAETARLRRELLEVKNREHTYARRDLALLNLQDRAKEQVEGDSAPGTDLLSTGPSLPGQSTDLGWLQADSSFDPSFDYFLSLEDSVPSSLDVSGGIHVPVTCSSSPAILAI</sequence>
</entry>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="103"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="305" mass="34536" checksum="6AD6C69A5D930046" modified="2013-06-26" version="1">MPSNRKRYKGCTFRRRYVGAFLFLLASILIGLVASTDGPEPSVEAYYSSLESRLGYWLLLGNVRHCGLYAKGQLSPFPISKAQQAMEDKLYRRLGLNPGDRVLDAGAGSGYVAMTMARRGLDVQAIDITPHHIADAKKNIEKYGLQDRIKVDYANYHNLSQFPDASFDGIYTMETFVHADDPIRVLNNFKRLLKTGGVLVLHEADISRDSGKLHDVLRLSHCQNTLPQGAYEELVKTAGFKDFSLEDLTDEVLPMWRLFGVLCYVPYQIFKLFGIQDRFINVMAGVDTWLNWGDRRYISVRAVKP</sequence>
</entry>
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    <accession>R0JYK6</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="nucleotide sequence ID" value="XM_008032637.1"/>
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    <dbReference type="STRING" id="671987.R0JYK6"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:FAD binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
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        <property type="entry name" value="Oxid_FAD_bind_N"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="367" mass="38992" checksum="3A70DF8CD0E45D20" modified="2013-06-26" version="1">MSAPPATITTAPLIRRAVTTIGYISTNEYDGTTFWDTITANDQGNIIATSDNLFQICDVSKPCTFFTCSSDWVVFATTSLFCGGSSSTCSYWELATDINDKNPLTNYWCDAKTSVGGIIYMKTPEAVSASTTRTGSSVSSATGTSKSSIAPVTVSFTSASVIASERVTSISSLGPGLDQTNGKNDSKGKSTPVGAIAGGVVGGVVVLGAIIFGVWFWLRRKKHNQTNNANITQPTQQTSLPPSQMQQQSPQQPPAGVQYYHEQKPVPQPQVQQVPPPAPAPALAPAQQPYGHYDPNAHSTYVQQSQGSYSMSPDQTTTSVTTAQHHQTHSYYAESGSISPVPQYSPSPSPAVPPVPPNMNELSSERM</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82232.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_008030072.1">
        <property type="nucleotide sequence ID" value="XM_008031881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1D8"/>
    <dbReference type="GeneID" id="19402677"/>
    <dbReference type="HOGENOM" id="CLU_126889_0_0_1"/>
    <dbReference type="OrthoDB" id="3796976at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        </location>
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    </feature>
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    </feature>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA82232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="219" mass="24526" checksum="BAE498EB3D654105" modified="2013-06-26" version="1">MPKVQKPRAPRAQTSTEQKRTRAARVEQEGVEMDFRCKRCEEKKLRCFVETSSGRCAGCISVGAECSLFVSEKEWEEVQAECERKELELAQAEERQALAAAESSRLRRELLEVKNKKRGFARRDLAIIAVQDRAKEQAEGSSAPGGTSLPVVEPSLSESSADLGGLQADFYDPSFDYLSLDFFLSYENPVLVSVDASDGTHVLDFFDYVLVVFEFDVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1W4</accession>
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        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
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        <name evidence="2" type="ORF">SETTUDRAFT_95247</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343770" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23991" checksum="A177EC683183DCC0" modified="2013-06-26" version="1">MFNKTSALLLLTLFSTQISSAPTPQQDPASAFLPIQYICHHVYPSDLTIVNSRYPSPGSERLHGSTSMFMLRRQRANEGEIATRVQFTGLPLILSNYTCRLEFVLPREDLQRIAGANPSFHVYQVTREAGAVATWETYEGNGNASLFGTVNGEEEALRRTKSVSGVAAVKETACNETLTFQMGLMYDGEYTPNYWQFLNVGPPAYPVQGFRIAYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2D2</accession>
    <name>R0K2D2_EXST2</name>
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        <recommendedName>
            <fullName evidence="10">MTHFR SAM-binding regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_93247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028272.1">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2S4"/>
    <dbReference type="GeneID" id="19405954"/>
    <dbReference type="HOGENOM" id="CLU_1396071_0_0_1"/>
    <dbReference type="OrthoDB" id="3670100at2759"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="195" mass="21580" checksum="19362746C77A6A87" modified="2013-06-26" version="1">MTKTIQDVYSNYNLVDESSHEALKERISQKARDLLPRYMEPVPLDFAVHNYESLMRTSYDAGTGIGLTNVALQAFTDVKESSRGGLGSKIDIIVVKGTVPRAHVGFLLETNIEIQNSIYTSKKSKRLQIMDSCGICFAILPNTGAGDIWNRLSYRGNRNRGFCNSVELPTNISPHAVTGEFVRRMVLGSAYSTAV</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">SETTUDRAFT_21387</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K388"/>
    <dbReference type="GeneID" id="19402428"/>
    <dbReference type="HOGENOM" id="CLU_1170479_0_0_1"/>
    <dbReference type="OrthoDB" id="3684928at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="220" mass="23546" checksum="72DF7FA677E5BB1C" modified="2013-06-26" version="1">MGDLAVQFNAATPTNVDGVMVNAIASNSLSVRVGTEERLPGTYTLLISGNGTCNPSSSSSLCKMQPGLISSTQKTLVNGKMVYELVDPSKPSSESQAAAELSTDYLPLLDGSKQLLINTTDGQPQDTATLVAEPFATEHTVASNVYKASTQRGLGRMGFNLATRTMVARARKSREPRPRKPVRNITLNFGNRTQSEGSSEILHTTSLIWAFAALTIFHVV</sequence>
</entry>
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    <accession>R0K4R9</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4R9"/>
    <dbReference type="STRING" id="671987.R0K4R9"/>
    <dbReference type="GeneID" id="19401664"/>
    <dbReference type="eggNOG" id="ENOG502SX4G">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="191139at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR002110">
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50297">
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49521" checksum="6F1DC09A3B5442C2" modified="2013-06-26" version="1">MPSARILVIHDDTFHARFPTRPQACISHQYEVLTHVYNKCKTGIKMAELVSSIITIATLGLAAIKECASYIEAVRTVDKLVDRLLEKITNLHEMVRHVNLTHHKAEADESSESSKLVRDKIILCRQRLRQIKPRIVDLASLNSETLMEKTILKRNFDQVTRDIEFAVQDINNYMADINTLFNCWRLELAHSARRHSEISRLHAPSASHRRASESMRPQSNPFELRGPLSSSASVESNHELHTLVRTQSAARSDFHSPPSTFSQSPLDDTESVSSAPSSAPPKDEEEWKYFHSKILKCIDDEFLVDEIRSMLEHAPDAVALANIPGKCQRVPLHIAAQRGFRRVACVLLEFDADINAKDTEPSSVLDHALANRQTDFVAFLLEHHVDETGILERNIPALRQAKSTIKLQTDQVARRSSVPVRNEGCKFSFIRRRKHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5P6</accession>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporineae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023810.1">
        <property type="nucleotide sequence ID" value="XM_008025619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K5P6"/>
    <dbReference type="STRING" id="671987.R0K5P6"/>
    <dbReference type="GeneID" id="19400492"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_0_1"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA88358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="340" mass="39192" checksum="28EAE6C7B22A1131" modified="2013-06-26" version="1">MWTDDSIKTEGPTIAEKDALLKRENGVSEQSPMRLRMEQFIKQHQKQIIAELEKVDGTKFKIDAWQRPEGGGGITCVLQDGNVFEKGGVNTSVVYGRLPRAAIQKMRVNHKALDPDVDSLAFFAAGLSMVLHPHNPNAPTVHLNYRYFETADEFGNTNAWWYGGGCDLTPCYLYDEDAILFHGAIKQACDKHDKAYYPRFKKWCDDYFNNKHRGETRGVGGIFFDDLDETEKDQEQLFCFIQDCLSAFLPSYLPIINRRKDMPFTPEMKQWQQIRRGRYVEFNLVHDRGTAFGLNTPGSRVESILMSLPLTARWQYMHAPEKGSREERLLEVLKKPKEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7E0</accession>
    <name>R0K7E0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_21540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028024.1">
        <property type="nucleotide sequence ID" value="XM_008029833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7E0"/>
    <dbReference type="STRING" id="671987.R0K7E0"/>
    <dbReference type="GeneID" id="19402442"/>
    <dbReference type="eggNOG" id="ENOG502SJ5Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_1_0_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005145267" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA84182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="449" mass="48258" checksum="D7B331C6F8A754BD" modified="2013-06-26" version="1">MKARLLLSVLGAAVAPALAAVATRQTKGNLPPVTVKGNAFFTGNDRFYIRGVAYQPGGASDAADPLLDLTSLKRDVENFKKLGINTIRIYTIDNSKNHDEGMKMLDDAGIYLALDANTPKYSLNRENAKTLHTSYNDVYLQSVFATIDAFAPYNNLLVFFSGNEVINAKNNSNAAPYIKAVTRDMKQYIANRYNRAIPVGYSAADVSENIEQQAFYFNCGTDDERSDFFAFNDYSWCDPSSFTISGWDQKVKTYGSYSKPIFLSEFGCITNTRQWGEIASLYSKNMTSVYSGGLAYEYTVEPNGYGLVEVGSGGKITPNADFDRLAKALKNTPNPTGDGGYKQDGKASECPKESDNWQVEGTSLPAIPKKAAQYMKDGAGKGPGLSGDGSHFSGEPSESTATAGSGQPSRTPGSGSSPNNQGAAAGLDIPLRFLGMIAASTLFGAVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8B7</accession>
    <name>R0K8B7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_40110</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="291" mass="32941" checksum="2686AC3BF1F14C42" modified="2013-06-26" version="1">MPSIEHPTIKDGWFREISGMWPGQAMTLQVKEVLHHEKSKYQDVLIFESTDYGTVLVLDNVIQCTERDEFSYQEMITHLAMNSHPNPEKVLVIGGGDGGVLREVVKHDCVKEAVLCDIDEAVIRLSKQYLPGMSVGFEHPKTTTIVGDGFKFLEDKKGEFDVIITDSSDPEGPAEALFQKEYFQLLNGALREGGVITTQAENQWLHMPLIVNLKKACKEVFPTVEYAYTTIPTYPSGQIGFMVCSKDATRDLKKPLRSWSTEEEESLCRYYSKEIHEASFVLPIFARKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KC02</accession>
    <name>R0KC02_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_163039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025481.1">
        <property type="nucleotide sequence ID" value="XM_008027290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KC02"/>
    <dbReference type="STRING" id="671987.R0KC02"/>
    <dbReference type="GeneID" id="19398631"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073203_0_0_1"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA86929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="255" mass="27933" checksum="F78AB84E951C1AF9" modified="2013-06-26" version="1">MSSSTVSVSAATPTQHHPFQRKVDDVKPSKTDINFVIMDYLVSEGYPRAAEKFAKEANIQLPLEEESIQSRVEIRRAIHAGDIDTAITKINDLNPQILDTDPALHFDLLRLQLIELIRACTSSAASDITPALNFASSQLAPRAATNADFLRDLELTMSLLIFLPAAPGTLQRELNELLEPSLRRNVASKVNEAILTSMGARGECRMRSLVRLRQWAETKARAAGKDLPSSLPLGLQDADDRPANGHGEAADVMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCN3</accession>
    <name>R0KCN3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_166601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021437.1">
        <property type="nucleotide sequence ID" value="XM_008023246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCN3"/>
    <dbReference type="GeneID" id="19399865"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_2_1_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="327" mass="36680" checksum="51B8894027D55E75" modified="2013-06-26" version="1">MPSAPPALIKTRFLVISDTHAASPSENAARNDTPFRPPLPRADVLLHCGDMTMVGLLEEYQKTLDMLEGIDAGLKLVIAGNHDISLDAEYYSRKGQRMHGIKHVDSCPARAREMWTGERAKKARVTYLDEGTHTFTLDNGANLRVYASPYQPEFCDWAFPYYRDEDRYNASHQCTPYAKPIAQNPVPDFPSIDVMMTHGPPMGVLDQTNRGESVGCQHLLRAARRCRPRMHCFGHIHEAWGAQKVLWNDGELDVHDPKQHIRKAEPIKVDNGSARNQRAVTVDISQGTHSAVTFGKETLMVNASIMTLQYAPWNGPWLVDLDLEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCU4</accession>
    <name>R0KCU4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_135770</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908593">
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        <source>
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    </evidence>
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        <source>
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    <sequence length="102" mass="11063" checksum="7A223219005647B8" modified="2013-06-26" version="1">MRSSTIILGLLSLIGSAIAGKHHNCGCDIQGKYDVDLSHKTCDRWARNNNPNTHFDGYSCVDKGTGRGIDGAPWEATCRDEWTSTAGHLGTDVTGDCWHDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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            <end position="123"/>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="123" mass="14050" checksum="78484218E85B90F2" modified="2013-06-26" version="1">MRCIHISSPMRIYLYMGMLTMAAQLCMAAHPGQAGTNSYCNTEDDGRKRRGPRCTAEASDQCIDQYCQDQCNNDRSVHRYNLPTPGEPLQCDCYSSIGTPRPQLFGTTTQPRRRYTKLERFET</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
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    <dbReference type="EMBL" id="KB908482">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KE92"/>
    <dbReference type="STRING" id="671987.R0KE92"/>
    <dbReference type="GeneID" id="19399995"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020349_0_0_1"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="163"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="447" mass="50972" checksum="89EA6597C1DD5598" modified="2013-06-26" version="1">MQSSVTPFGYSSESCGYCKDAAQGRRTANSRASYYFSSKSLTVDVYQLLVDRGWRRSGSIFYKPDVLRHCCPHYTIRLPVASFKPSKDQRKAINRWNDHVLGESYLKEASRLYPLSKEEKARLKNTFDLAREVHKAELHNVKRPPEPAHRFEVTLEPASFTHEKYDLFNNYQQTVHKEKPSEISQSGFKRFLCETPLKRTSRTVDGKEQPLGSYHQCYRLDGRLIAMGVLDLLPHCVSGVYMLYHSDFAEWQFGKLSALREAALALEGGYQYYYMGYYIHSCTKMKYKGDYKTQHVLDPESYEWHPLDGELRSLLDKKKYVSMSRERRRQLEKASAQDKTGDAEAAEQDDYSDYPLPTAAAAGEAVSSGMSLFELKVPGLMTAEEIEEKLDLATMPIRVGSRLVELQDLVSWESSDLRNPRSIQGVVGEMVAGMGPEAAWQIVIQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFH8</accession>
    <name>R0KFH8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_19384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024907.1">
        <property type="nucleotide sequence ID" value="XM_008026716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFH8"/>
    <dbReference type="STRING" id="671987.R0KFH8"/>
    <dbReference type="GeneID" id="19402194"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA86867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="443" mass="49195" checksum="4555EC19843AD146" modified="2013-06-26" version="1">MVAENFAAKQAEAVLGHDQQDSVTHTDIANPDRDGKKYADPSGEKMKALVWMGKNSSSSLGCGTKDVSKPKIVEDHDVLVRITGSTVCGSDVHLLHGVIIQTEKGDVLGHEFCGIVEEVGSAIKERKVGDRVVNSFVVSCGECRFCKQNLTTACDKTNSSALQKFLYGERTAGIFGYSHFVGGYAGGQAEYVRVPFGDQNLLKLPDNIPFEKGKLPNFFYAWKMLRKRRDLGLGPIGLMACVWAFKKGAKRVIGIDNNWRTEFAKQKIPGLETINYEELKKQSVPAKIHELVPGGVDACNEASGGEYAKAWTHKLRMLSGLEQDTSEMINECIYSTRKFGRVGIIGDYTGFTSHFNVGALMERGIRLVGCGQAPVQKYWKEILEMLEKGEIDPTIMLTHRFKIEDIAKAYYMQEKRKDGLLKCFVETRFSEPRASGTPELKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFI8</accession>
    <name>R0KFI8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_152662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020736.1">
        <property type="nucleotide sequence ID" value="XM_008022545.1"/>
    </dbReference>
    <dbReference type="SMR" id="R0KFI8"/>
    <dbReference type="STRING" id="671987.R0KFI8"/>
    <dbReference type="GeneID" id="19397214"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_4_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="6">
        <location>
            <begin position="382"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="7">
        <location>
            <begin position="1292"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1679"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1292"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1462"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2033" mass="219956" checksum="FAE63E43D92024B9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFQ7</accession>
    <name>R0KFQ7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SETTUDRAFT_162295</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020768.1">
        <property type="nucleotide sequence ID" value="XM_008022577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFQ7"/>
    <dbReference type="STRING" id="671987.R0KFQ7"/>
    <dbReference type="GeneID" id="19398342"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990305">
        <property type="term" value="C:RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990303">
        <property type="term" value="C:UBR1-RAD6 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090089">
        <property type="term" value="P:regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
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            <end position="150"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFY3</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the SEC3 family.</text>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="1496" mass="166043" checksum="9ABD6462A87D2CC1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA88327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="462" mass="51213" checksum="ED42562442BD27BB" modified="2013-06-26" version="1">MSAPASATSELPMRSPTMRSGDDEVVPGEDTSEVTKLFAERLQAWKHAVGYLEDYITATEKTNSAHGKEYERVLKTVKDPLKEGHHFDQSLGGIAGMFENIRSNTQGMSNQHYETAKQLKSVILPIFERLHTEIKNKSKELTKGAGKGSKAVDKARQQTQKHIEMLGQYAAAFDSHGSAQMKATDDPYIIRRGVNHRLNKQVQEENNNRQDLIAVQNSFAQFEAHIIQEIQHGMTQFLQVMTTQAEHTKASYGDMVGTCQRTPLDFEWNGFIQRNNTILIDPSAPARTLADISFPNQHHRSTQPLISGSLEKRGKIMRSYDTNYYVVTPSKFLHEFKTDDDFAKDPTPELSLYLPDCTIGAVNGNKFNIKGKDTSKGKIGGAFSMNHEINFKAHTPQAAQQWWDVLRQAAGSVTTDAPDSSVPTSPITPVSEKQPSPLQTQGLEKTGTNTTQPGSAVPASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLB5</accession>
    <name>R0KLB5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_168013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023437.1">
        <property type="nucleotide sequence ID" value="XM_008025246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLB5"/>
    <dbReference type="STRING" id="671987.R0KLB5"/>
    <dbReference type="GeneID" id="19400392"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_0_2_1"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA88757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="287" mass="31477" checksum="8959A7F8F9E406DD" modified="2013-06-26" version="1">MVSSQPPAASKIPSTKPDTRGFPRILCLHGGGVNAAIFEAQSRALIRHLQHSFRLVWADAPFFCDPHSDIIGVYSDYAPFRRWLRWLPEHPEVDDETCIEENGYAIRTAMEDDDQAGGTGEWVGLMGFSQGAKMSASLLLEQQAREADARKRGYTVVAPGPTGIPNLTWRFGVLLAGRAPLSNFNPQLLKSKALVDAGSLSEGFQFCSEVDEEATLKRPTLHVHGMADPGLNLHRKLLDEYCEKGSATLVEWEGAHRVPLKSGDVNRVVGAIYDIAEATGVRVLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLF3</accession>
    <name>R0KLF3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_38111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023324.1">
        <property type="nucleotide sequence ID" value="XM_008025133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLF3"/>
    <dbReference type="GeneID" id="19404325"/>
    <dbReference type="HOGENOM" id="CLU_1950157_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="129" mass="12968" checksum="E1190E08600D685A" modified="2013-06-26" version="1">MAAARPAVVWARSGGASSISGAGAGAGVGAGAGVVMSGVGGELQLLHNDYQYSQVPAVSVCLPVNCKADVNEFPMPLRISNVALFFGVVFVCVGSVARNIGVRPWLSSAMAASGEKQALCQSGAVSIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLY1</accession>
    <name>R0KLY1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF605-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_148533</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023581.1">
        <property type="nucleotide sequence ID" value="XM_008025390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLY1"/>
    <dbReference type="STRING" id="671987.R0KLY1"/>
    <dbReference type="GeneID" id="19396981"/>
    <dbReference type="eggNOG" id="KOG0917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030378_0_0_1"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="399"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA88952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47116" checksum="BF967ECFA37E1E47" modified="2013-06-26" version="1">MASVTPAKLKKLQLAEPAKRAAQLERIKPIITYWLRFYMVQKIIAGGLHSADQECTAYTTDLMERLEQAKAENPSEDALVDDTVASAYCEQFALQTLGKAEREMAENRVNGQTVDTLRAASTFLEMMSIWKNNDAEIAAKTKYAKYHALRILKAIKAGEDPNATNPVHDTPEQPVSPPALDPEDPEVQRINQAAAAQPPENPYQPYVESAPDTSVQPSPSLSAPPVSPPPPNLPSAPTGYTHTSHSDVSPISQPAQSRQGSVTSIGGGYFPKTDPPTFTGESAPPGLPTAPMDRDPLTSSLPTSPQVPQAPEASDPSGFYQNTASPPAAAPTQNSYQPPQNQFASPSPQPPQQQYAPPTSAFPPQQQYPPAPHQNPYAQPPPPSQPPQQFSNGPFRNDEDSIMLAQKHAKWAISALNFEDADTAVKELRTALRALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0KN18</accession>
    <name>R0KN18_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_37122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021914.1">
        <property type="nucleotide sequence ID" value="XM_008023723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KN18"/>
    <dbReference type="STRING" id="671987.R0KN18"/>
    <dbReference type="GeneID" id="19404219"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_82_4_1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="636"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="788"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1257" mass="141331" checksum="74CFD8047D81B9E9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>R0KN40</accession>
    <name>R0KN40_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_126628</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 22">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022325.1">
        <property type="nucleotide sequence ID" value="XM_008024134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KN40"/>
    <dbReference type="STRING" id="671987.R0KN40"/>
    <dbReference type="GeneID" id="19395992"/>
    <dbReference type="eggNOG" id="KOG0883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="308"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EOA90499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="567" mass="62329" checksum="62D5DF993D6B5AF0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNL7</accession>
    <name>R0KNL7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_101600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021425.1">
        <property type="nucleotide sequence ID" value="XM_008023234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNL7"/>
    <dbReference type="GeneID" id="19394867"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
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    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021786.1">
        <property type="nucleotide sequence ID" value="XM_008023595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQ73"/>
    <dbReference type="STRING" id="671987.R0KQ73"/>
    <dbReference type="GeneID" id="19399996"/>
    <dbReference type="eggNOG" id="KOG1639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059260_0_1_1"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="155"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EOA91159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="305" mass="34045" checksum="93A619032391853F" modified="2013-06-26" version="1">MSSAPLTLVVRPRGRPIKNLPETVTVSADASAAQIFEEIAKASKFSAHRLRVTKGSDGSPIPNTRDVKVYDTGLRNKSAVDVKDLGPQISWRTVFIVEYLGPLLIHPLFYYGRPLIYGTSAPPSELQKLTMLMCVMHFAKREYETLFVHRFSSATMPAFNIVKNSGHYWLLSGLNLAYWSYSPSSPAAGPSNPLLTYLGLALFAIGEVCNFSTHVTLKNLRRPGSTERGIPQGLGFNLVTCPNYMFESMAWIGVALVNCSLSTVLFIVVAVGQMGVWAWKKEKRYRKEFGDKYKRKRYAILPGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KR63</accession>
    <name>R0KR63_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_152589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020682.1">
        <property type="nucleotide sequence ID" value="XM_008022491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KR63"/>
    <dbReference type="STRING" id="671987.R0KR63"/>
    <dbReference type="GeneID" id="19397208"/>
    <dbReference type="eggNOG" id="KOG0265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_2_1"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA91494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37998" checksum="703F75ED001D62B1" modified="2013-06-26" version="1">MSREKRPANEAFGTSQLVKRTKSDANLGGSSAVAVVSGSGANGALIQAGSRSSALQSPVMELTGHSGEVFAARFDPTGQYIASGSMDRSILLWRSSGSCENYGILTGHKQAVLDLHWSRDSKVLFSASADMHLASWDVETGERIRRHPGHEEVINCMDVSKRGEEMLVSGSDDGHIGMWDTRSKDAVTFIPTDFPITAICLAEAGNELFTGGIDNDIKVWDLRKQAVTYTLIGHTDTVTSLQMSPDNQTLLSNAHDSTVRTWDVRPFAPADRHVQTYDGAPTGQERNLLKACWDVKGDRIAAGSGDQSVAVWETRSGKLLHKLPGHRGAVNDVRFHPLGEPIFVSGAAARCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRR5</accession>
    <name>R0KRR5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_133430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Kosti I."/>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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            <end position="1306"/>
        </location>
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        <location>
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            <end position="1505"/>
        </location>
    </feature>
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        <location>
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            <end position="89"/>
        </location>
    </feature>
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            <end position="241"/>
        </location>
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        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
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            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0I537</accession>
    <name>R0I537_EXST2</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_174481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="329" mass="35999" checksum="48E89A46464229D8" modified="2013-06-26" version="1">MPSTKSKNIIITGGARGLGRCTARHLLSLPVSHRVFIIDFNEEELEYAVNTHLAAYAPRVGSSVTNLCKPEEIRSAAAQAAEFFGGRIDVLINNAGIARGFFNAGNGTMEDVATGEQWEAYIATNLSAPFYMSQAVIPFMKSKNTQKEGAPGVDRKKDLKRTDEFNQLPLNLHGEDKLDEGGCIINIASFRAHQSDPDCEGYAASKGGVLALTQAMSISCQRWGIRVMAISPGWVHVDHECKAKDLKLKEAQNGSYKEVAPHEEAARKMRLQAWADDLDELYHKQHPAGRVGRGEDLAEMVEYVMGAGFLSGQELILDGGANRRKNPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5C5</accession>
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        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="4 5">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0I5C5"/>
    <dbReference type="GeneID" id="19399758"/>
    <dbReference type="eggNOG" id="ENOG502RX7Y">
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    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA80860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="667" mass="74263" checksum="DDDEB7DCA0BFCCD1" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5D0</accession>
    <name>R0I5D0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eisosome protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_124025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
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            <dbReference type="Pfam" id="PF03893"/>
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            <dbReference type="EMBL" id="EOA81330.1"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="314" mass="34508" checksum="2955AF5A33A541E4" modified="2013-06-26" version="1">MRAFSTLALAALLGAFTSNASPFAKRRPVSETLLADMKLMSQYASAAYCKPNIDSPGGTVYCGSGKCPLVQAANVESLEEYSEAETSTDVTGYIAADHTHKLLIVAFRGSRTPDNWITNFDFAMMPTTLCPKCVAHSGFWRSWTDARRRVVSALKNSTAQYPGYQIRVTGHSLGGAVATFAAAGLRTEGFDVAMYTFGAPRIGGPSVSDFISKQAGGNYRITHWNDPVSRIPFLTMGYVHVTPEYYIDVKNKQEVRTSDIKVLDGSWNLKGNAKWLAMDPEAHMWFFHHLNVCGGKKSKRRGALAEDMHVIARF</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35802" checksum="6CDF2E146365B0A5" modified="2013-06-26" version="1">MLDFPPVVRVELQPMPHEAHIRRPGEDWAGITNPKERKRLQNRLNKRVSRQRKRTMCYEDDSSDSTCSGGTSPDAFCMDICVPSAAVVVSAMAAVTESNCASPASSSSCITVSTFSHCSQADAAQKRAMLERFAQQALVSYMTADPCADHHLKLLQFNTINGFTKNAGALGYQFDWLVCAAVSPFGCNGPGRSAVGPAAAAVVPSSLKPTTMQLTTRHHPWLDLFPFPRMRDNLLIAAGVLSPEEEQQLFTDVMESDGGKDEWTGLVLWGEPWDPQSWEVSLPFLKRWAWLVNGCPEIITSTNHWRRKRGEDAISAPGFVLDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9P0</accession>
    <name>R0I9P0_EXST2</name>
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        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_43991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA82071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030161.1">
        <property type="nucleotide sequence ID" value="XM_008031970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9P0"/>
    <dbReference type="STRING" id="671987.R0I9P0"/>
    <dbReference type="GeneID" id="19404892"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021544_2_0_1"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="100"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="674" mass="74112" checksum="3F0D5113FB5BE721" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9Z9</accession>
    <name>R0I9Z9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_44034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030166.1">
        <property type="nucleotide sequence ID" value="XM_008031975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9Z9"/>
    <dbReference type="GeneID" id="19404897"/>
    <dbReference type="HOGENOM" id="CLU_592062_0_0_1"/>
    <dbReference type="OrthoDB" id="10635389at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="462" mass="52909" checksum="DBAEB9AB05A6D0D1" modified="2013-06-26" version="1">MPVNSGRHASSRKRLPPEGRPVQQTRPSSQKGKFKVWLGNTKRERHEPSESDVEVDLRDAQELESCIGSLWKGERLPRKLSLFCIKAKDVGMSLDRDQKRALLKALANTEIYPKKEMHLSIRTVKSETGGEHEGIDKKAELSYAAILIIDLALRDEQDIDTRDLFAEMVGCATPDTILELSFVLRYPFITLTELPTLIHCTVRHIARIDKNDRAKQPVKLAIETATAIATTLEHAEELQPQKLRADRSLWSGKYDRVGREKALVSSCKRALDDLLFGTLRRAKYLQENYYADDDDAARQNPVQTDEKNKEKESKEDRLYRYSRDLGCHAGLLLAGIQAYFLRSKENDEDMEIKCDLLIDVMSGFLNGVPTVGFVFGPAGSVAKTLFHKFSSEKKKKRREQVSQGIKEYFDESVWAPIFFDDEFFLEDAHGTALIAPEKVEWAVFSKWYEQIIRWNQAFVNWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IA55</accession>
    <name>R0IA55_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">SETTUDRAFT_34939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030132.1">
        <property type="nucleotide sequence ID" value="XM_008031941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IA55"/>
    <dbReference type="STRING" id="671987.R0IA55"/>
    <dbReference type="GeneID" id="19403966"/>
    <dbReference type="eggNOG" id="ENOG502QXG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792651_0_0_1"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA82201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="350" mass="37621" checksum="DDD3E05A2C748E50" modified="2013-06-26" version="1">MNSQSNGGYATTHTTTSSDRSPHSSLPMSHSLSQSAASASSQHPFSTPASTAGFLSSATIDSDGDATMEESVDDDVAASRNHRLSNHNRQPESPYTPDGRLKAAQGISGPQLFKLGTEKIQKSRPHASQNLIRLYRLEPLASSVARNDPVTGEKINKLRKSYEGHIKQMQIAGKPKATKMDGVFRDLLMLPEEIWQPNHVQNREPDKTALTPDGTGLAPEFSQLLDGAFAGMGPGSLPNADAAKYKAYLGTDDAIKPKAQDAPPQRTTPYTSSAPTPNNHINRGLVRPERSGSKRGYTDAAFQGYGEGFGDDYADSTGGEDTPGGTMANKRRKLQFERTSHSVEVGGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICN5</accession>
    <name>R0ICN5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_96395</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029938.1">
        <property type="nucleotide sequence ID" value="XM_008031747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ICN5"/>
    <dbReference type="STRING" id="671987.R0ICN5"/>
    <dbReference type="GeneID" id="19406230"/>
    <dbReference type="eggNOG" id="KOG4718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045153_0_0_1"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA82961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="333" mass="37748" checksum="AC3D0F961476CD68" modified="2013-06-26" version="1">MSRSASPFVRAPTEEEGYNSTHRAFLQAFHTHGVLTVNEMKPILAHIMTAYNPNRPWTQGDVTPAMLNTMIQTINGQLEAFDYEIRSMRDQQSKETMYALVNNTSDALTQFATTFSANEIAYIRRLLDHMFETNNTSVRETMAVKHTEASQLARASRRSRQSQGALHQHDTQDSQQADTSISIADADMVLDRLVAQAFLHKSRAGYYSLAPRALMELRAYLKETYNDDDGGDDDGDDAHAVIRIRDCEGCREIVTYGVRCNNRECGVRWHDACANSYYRGRRDSERKCPRCKTECTGDVFVGERADTMASRKSQGGRRGVDEEEEAEEEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0IDM7</accession>
    <name>R0IDM7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_164826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029163.1">
        <property type="nucleotide sequence ID" value="XM_008030972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IDM7"/>
    <dbReference type="STRING" id="671987.R0IDM7"/>
    <dbReference type="GeneID" id="19399258"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA83450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="185" mass="20380" checksum="6F0CEF63472D19A9" modified="2013-06-26" version="1">MRPLTEPETKTLFEKLASYCGKGITNLIADPAGGSDRNVFRVQGSRVYYVRESIANLATSVARDNLLSLGICLGKFTKTGKFRLHITALSVIAPHARYKVWVKQNGEMPFLYGGNVLKAHVGRWSEDCPEHQGVVVLSMNDTPLGFGVSARSTADARKLDPTGIVTFRQADIGEYLREEDSLFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0IEV2</accession>
    <name>R0IEV2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 16">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 16">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 16">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SETTUDRAFT_140307</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 16"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029279.1">
        <property type="nucleotide sequence ID" value="XM_008031088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IEV2"/>
    <dbReference type="STRING" id="671987.R0IEV2"/>
    <dbReference type="GeneID" id="19396552"/>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021710_0_2_1"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="19">
        <location>
            <begin position="46"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="20">
        <location>
            <begin position="256"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="17">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EOA83611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="426" mass="49319" checksum="F580B26C5234A6C0" modified="2013-06-26" version="1">MPTTAPTHAPPPQIPGFLIPNQEAQPLKQVVADLLERDNLRFPGAQPVSFAREHVAELQRNEYFMCEKTDGLRCLLFLHWHEGPTGAFEPLTFLIDRKNNYYNVQPPFRIPHYMHPNEPEPFLYGTILDGELVHDQYPNEPAPRLNFYVFDCLAVNEQNVTGRTLDKRLGRLHDWVIKPYEMYLTRTFGKNIRPDDLKPFALKGKKTYAAYKLEDMFSNILPNLRHGNDGLIFTCVSTPYQFGTDRHILKWKPPHENTIDFKLRLGEFPLMDPEDDEEGLIPDYDAMPCPIELLVQHNSNNYQVFSTLALTQAEWETLKSLNQRLDGRIIECYRTESGQWKYKAEADGTPRWRDDKKDANHISTVNSVLESIEAPVTEMDLLGNAENIKRETYRMQGKLDQYRPPQDAGEREAKKRKFSDSGMNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0IH52</accession>
    <name>R0IH52_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_21672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028048.1">
        <property type="nucleotide sequence ID" value="XM_008029857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IH52"/>
    <dbReference type="STRING" id="671987.R0IH52"/>
    <dbReference type="GeneID" id="19402466"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1161757_0_0_1"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="239" mass="25945" checksum="B6C9325A5D0FA59E" modified="2013-06-26" version="1">MGVNIIDVGVSRISGAREYQEDRYVTLLPGSLKSRKELAIFAVYDGHGGADVVNHVAQHLHTHLEQHFTNPKAANATEYKHAIQCALRAVDRELSRADLDGGSTVTLVLVDTKQNLLVQANLGDSHCYFADHDAQSPQSLSPHSPTRNNSTTSQAGWNVEPLSVEHTPDSPLEKRRIEESGGEINYTSGIALGRDTPSGARVGAPSPPTAMELSMPMRNKFRDPWGGINVATALHCLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0IH62</accession>
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        <recommendedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_20077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SJ74">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
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    </dbReference>
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        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBD9-like"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        <location>
            <begin position="24"/>
            <end position="471"/>
        </location>
    </feature>
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        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA84535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="471" mass="50757" checksum="47DC5FC0EC9B6065" modified="2013-06-26" version="1">MGLKQAVCMLLAVLALLISITTAENTASNITAASTFYLARTQTQFSVNIANDSQDVFIYFASPAYSWVGVGFGHKMAGSLMFIMYNNKDGSNVTISPRIGSAASEPTFNSSIDLTVLPGTWVNDSMLMLNARCSNCRSFIDTKSSTQPMIYAFGDGQNVMSNSPSAPLQRHVRYGFFTMNMLTATGPGGVPASSSAMNGVAIEGSMVRDHDRANLAHAVFGCLAVLIFWPMNVLAVTLFKNIKIHVVFSVLIMVLLIVSFALGGVISGQYNRSKAFNSPHQITAFLTILPLLLTSILPALTHLTTKVRALHTPLTSISFVLLVLTGGLGLRLSMQPTSLVLVYTGISIGVFIVLLILHTCLRKRGSAYARAQNRRPRSDTPDSPTTEEMLIMAKMHDSQNTAGLNPPPPYYPQQGYHSTGSAEFGADGQHVHPAQHSRSSSRTRQFGGGAMPGPQYLLNMHPGVPVQVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="GNAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="224" mass="25748" checksum="BF2D325F91FF56A3" modified="2013-06-26" version="1">MPDANLEISLLKPEEAEQYMRIRHQVFRPTINKILYARREPSEKTLNQVVEDIRDGILNKGIIYVKCIDKTTGEMIAGARWRYVKPKQEGAKERTWEEVDAGLTIPEPFEESEPEMWNSLFKLFAANKRELLGTRPYYVLDTLVTLDQHQRRGAGSMLVRWGCEKADEAGVEAFLEASPMGAPVYARHGFVPVKEVELDLRRWGGKEKLDFILMIRPAKQDSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIP9</accession>
    <name>R0IIP9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phosphoglucomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_154440</name>
    </gene>
    <organism evidence="16 17">
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        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027352.1">
        <property type="nucleotide sequence ID" value="XM_008029161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIP9"/>
    <dbReference type="STRING" id="671987.R0IIP9"/>
    <dbReference type="GeneID" id="19397407"/>
    <dbReference type="eggNOG" id="KOG1220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_1_1"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046115">
        <property type="term" value="P:guanosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006148">
        <property type="term" value="P:inosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="225"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="327"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="12">
        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA84816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="64333" checksum="BD3F65945279CBC7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIX6</accession>
    <name>R0IIX6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_137075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027414.1">
        <property type="nucleotide sequence ID" value="XM_008029223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIX6"/>
    <dbReference type="STRING" id="671987.R0IIX6"/>
    <dbReference type="GeneID" id="19396394"/>
    <dbReference type="eggNOG" id="ENOG502SMAR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="188"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="322" mass="34699" checksum="AF54F6F71AEC562F" modified="2013-06-26" version="1">MASGGQSRILLFGAGSVGAIYLHLLSKVASTAAVCRSNYDVVKQHGFVINSTIFGHDIRFKPQVVRDCAEASSLSPAPYDYVVVCSKAIPGVVPKLIASAVTPGHTAIVLIQNGVGIEDEYRHAYPDNPIVSAVLYLPATQRPAGVITHAEVELLQLGAFPSSSSNTHAKKFADLVTSAGGTAELHDDIQYMRWSKLLVNASWNPTCALARSKDAHVLTASPEATEVLRAVMLEIRDIAAAYGHNFTRELVDVQLSRAQDRVPNNTGIQPSMLQDVLAGRRIEVEAIVGNPVRLAKEKGVPCVRLEMLYVLAKALDLQIERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJ81</accession>
    <name>R0IJ81_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_90584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027660.1">
        <property type="nucleotide sequence ID" value="XM_008029469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJ81"/>
    <dbReference type="GeneID" id="19405846"/>
    <dbReference type="HOGENOM" id="CLU_1856542_0_0_1"/>
    <dbReference type="OrthoDB" id="2519291at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="138" mass="16015" checksum="E441343F5EEBEDB7" modified="2013-06-26" version="1">MNKNPPTKYPVVLTALTRRKEGTTIEEFLDYNENVFAPLVKKIAGKVYPLSWSRHYHVEDSECPMGLTRILVGSNVDESMDWDVIGEMLFEDELHLQQFITFLHSDAALEIFEEEAKFIDQSKKKMVVMKRAVTFRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILD2</accession>
    <name>R0ILD2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_39902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026398.1">
        <property type="nucleotide sequence ID" value="XM_008028207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILD2"/>
    <dbReference type="GeneID" id="19404538"/>
    <dbReference type="HOGENOM" id="CLU_1304750_0_0_1"/>
    <dbReference type="OrthoDB" id="3694496at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="219" mass="24512" checksum="BBB04FA2BEFD77E1" modified="2013-06-26" version="1">MANKKYATKTQALEARRICNKMAQRRYRDKKKQNQAGSKSSQQSRTMENETDGEALSAVQHPDASEQEASSEVENTPNKRRRPNPSSAPLTPLEHLAIMDQSVEALSVIDKDACDPKALMDGLTRIKTKLQHVVNHVHEWKQPALQQDASNVMSSHYNPHTSTVVSGSATSLNTKKIQALSAGMRRYCDEKKLHDMIAYYERAGTPAQLKITINPKLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IM56</accession>
    <name>R0IM56_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_28848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026380.1">
        <property type="nucleotide sequence ID" value="XM_008028189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IM56"/>
    <dbReference type="STRING" id="671987.R0IM56"/>
    <dbReference type="GeneID" id="19403282"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_0_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053212">
        <property type="entry name" value="DHP_3-monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054707">
        <property type="entry name" value="DhpH_subs-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469">
        <property type="entry name" value="MONOOXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469:SF2">
        <property type="entry name" value="OS06G0597600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22607">
        <property type="entry name" value="FAD_binding-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
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        <subcellularLocation>
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        <location>
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        </location>
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        <location>
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            <end position="475"/>
        </location>
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        <location>
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            <end position="551"/>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="1104"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
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        <property type="nucleotide sequence ID" value="XM_008026005.1"/>
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    <dbReference type="AlphaFoldDB" id="R0ITK2"/>
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    </dbReference>
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            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="301" mass="33301" checksum="AF3195C071569AAD" modified="2013-06-26" version="1">MPTFQANDGITLHYTTHGSRTAPPLILLHGFTGSSAVFKHNIDALAQHHHVIVPDLRGHGSSQKPQAGYHVSRLAVDVRNLLSHFRLTDSSNVRAIGTSLGAAILWSYSELFSTSVFSHLVFVDQAPLQNYLDDWGPEVGNRGCNSTESLREMQRSLISQPEHAHRGTIAACLGYRSHPRPGDPTAESQVWQEDEEFFLREAMRGEGWWYGKLMADHTANDWRYSIAQNLGPESGSAARVLVVASCRSGCFPAAGPLKVAELVNGGKEDGRATAVTVEWGGHWCYWEKPELFNKLVLEFLQ</sequence>
</entry>
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    <accession>R0ITP3</accession>
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        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
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    </protein>
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        <name evidence="6" type="ORF">SETTUDRAFT_168561</name>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008026017.1"/>
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    <dbReference type="STRING" id="671987.R0ITP3"/>
    <dbReference type="GeneID" id="19400588"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
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    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="787" mass="90729" checksum="E51CE8C68270FF49" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0J247</accession>
    <name>R0J247_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_166884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
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    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J247"/>
    <dbReference type="STRING" id="671987.R0J247"/>
    <dbReference type="GeneID" id="19399964"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="253"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="460" mass="52309" checksum="43DE27E759B1E3B7" modified="2013-06-26" version="1">MTDTNGSYAPNMRALPAGEFVKPSRKTNGAGVQAEDTRICVVMVGLPARGKSLIAQKVVRYLHWLSIKSKTFNVGQYRRTATPNPSAEFFDTSNPEGERLRKAAAEAAVNDMCKWFSEGRGLVAILDATNSTKSRRRWIQERCAADNIETLFVESKCDDEELIMSNILEVKTTSPDYVGQDPEVAAADFRNRIRNYEKVYQTIDEDERDLTYVKLINVGKQVIINQIQDYLQSRVVYYLMNLHIKPRSIWLSRHGESQYNLTGQIGGDANLSARGDAYAHALPGLVAKSVGDNRKLTVWTSTLKRTIQTARFLPFEKLEWKALDELDSGVCDGLTYAQIEEKYPEDFKQRDEDKYNYRYLGGESYRDVVIRLEPIIMELERSENILIVTHQAILRCIYAYFMNVPQEQSPWMEVPLHTLIKLTPKAYSTQEERLKADIPAVSTWRGKGTKAEHQQANGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0J378</accession>
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        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">SETTUDRAFT_85017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0J378"/>
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    <dbReference type="eggNOG" id="ENOG502QRI8">
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    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
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        <property type="entry name" value="RGS_sf"/>
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    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">28A</strain>
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    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF05064">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0813">Transport</keyword>
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            <end position="591"/>
        </location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00068864"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00081079"/>
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    </evidence>
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            <dbReference type="SAM" id="Coils"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF05064"/>
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            <dbReference type="EMBL" id="EOA91411.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="720" mass="70374" checksum="4B71F3224A3B4FAF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3X1</accession>
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            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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        <name evidence="8" type="ORF">SETTUDRAFT_170355</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020653.1">
        <property type="nucleotide sequence ID" value="XM_008022462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3X1"/>
    <dbReference type="GeneID" id="19401036"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000409">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000511">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="499" mass="55473" checksum="B00C93D910D5BEE0" modified="2013-06-26" version="1">MAAHNPAMPNDDMLEKHPVSLRENIDGSQDGSGYECEFTEREQRKIIHRIDRRLVVTVGVLYCISLMDRTNLSAASIAGMTAELHLKVLEGTISRYSVVTIVFFASYIVFQPPATVICRHLGPRNFLSFIVIAWGAVMIGMGFARSYGAMIGLRVLLGVLEAGFFPSCVYLLSTWYTRFDVGKRYSCFYILGSLASACAGILAYGLMQLKGREGLNGWRWIFIIEGALTCFLGFVGYWALVDFPDKAHKSWRFLTEREARFIIERVNRDRGDAKVEPWSLAKFLKGGTDIKIWGFAMIFFNTTTVTYALAYFLPIILTANMGFSVGAAQCLVAPPYAFAAIVMYTTGYLGDKYHLRGPIIIFNMVLCLVGLPIMGFHSNPNVRYFGVFLTTAGANSNIPATMSYQANNIRGQWKRAFCSAILVGMGGVGGIAGGLVFREQDAPGYEPGLYACIACCLLSIVLVCLITLRSWSLNKRADRGEIELEYNDDSDQKGFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0J477</accession>
    <name>R0J477_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_178050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020714.1">
        <property type="nucleotide sequence ID" value="XM_008022523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J477"/>
    <dbReference type="STRING" id="671987.R0J477"/>
    <dbReference type="GeneID" id="19401579"/>
    <dbReference type="eggNOG" id="ENOG502SKME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037866_0_0_1"/>
    <dbReference type="OrthoDB" id="4662583at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF11">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA91546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="435" mass="49784" checksum="49FCA2F7A3DDB805" modified="2013-06-26" version="1">MTNRTSSKTAPELKALDRSHETGAALSRLVEADGAGSWPPRANHGNWPIELLPYHEIYMDMVPFLSSGSPSLDDNVNIERRDRFRSLMIKKVNERVDMARVHGILTSIEAGDWSGCSREAYNGFYCCIGVLRHAYRWAIIPSVKVAQEEKIIDFPAQIDIPWVYLQRKFGFESDSGNNTSNVLHNFNDKGERAYKINQDVSEIVTATEDAFFRIFYDVEVMAYPMYQAMVGANIAFEQGNKVECLNHMRDINIQLRQLLKVFYQNLVESRVAKGVWLGYCQSFQAWGAGRMIDGEYVEFDGVSGSHNLCFMVIDAFLGMESYMTEQNMRRYIPHNQRAMIATFRKYSFFTKLQADKDKEISDEFCKIIQHLNVFRSAHRARVMPYLAQPAPERIMMTAGKSLNEATNDASHLEILDNMLVSRLKDTIVMAKQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4P5</accession>
    <name>R0J4P5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_152736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020786.1">
        <property type="nucleotide sequence ID" value="XM_008022595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J4P5"/>
    <dbReference type="STRING" id="671987.R0J4P5"/>
    <dbReference type="GeneID" id="19397221"/>
    <dbReference type="eggNOG" id="ENOG502QVCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473268_0_0_1"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA91681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="489" mass="55043" checksum="B12DA843E256E5B3" modified="2013-06-26" version="1">MAASHLMNECRLLEHAPDFARVRPEAYLDNVKTEYAAKLAVCELLSAQPVNSAAPPHCDVLIPAARHCGKSGSWWHAQAVVSSDKQCYPTFKERQYIQCLKSLQSTPQYWTSFSNARQNAVVMCQASRDAIERENHLEVFKNLTQVLGGVITNMQKTNEEYESLIRQQRRHSEEVRDTHQQLNEELQAVRAKAVSTVEAMDSKFHTFMESSISDFITALGTSQSKEMDKIRERMQEFSQDLIVESSQLAKYFSDQLQQYHERTLANLQVNHEAQVHSYTVLSGYMATAQKTMNTTNDVADRSLSKVDSIAQRLDLFESQTEHIAEGFAFLSAIPALFRLIVRRFVATIGTAFIFAILCRLNTRLATYTAGACSSAFLLHTSGVFDWLAAIPSSITNMQSQSPLAILITMSSWNKGTGLVLLLWLAAYPVCRLNIYLGTLVTTAARRLLAHLWLSEYTNDGGTGYLPSIEVPAITQRKDEKHTSYRQLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4Y2</accession>
    <name>R0J4Y2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_170586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020857.1">
        <property type="nucleotide sequence ID" value="XM_008022666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J4Y2"/>
    <dbReference type="STRING" id="671987.R0J4Y2"/>
    <dbReference type="GeneID" id="19401050"/>
    <dbReference type="eggNOG" id="KOG4759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057161_1_0_1"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="6">
        <location>
            <begin position="107"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="280" mass="30482" checksum="04618987F55CE478" modified="2013-06-26" version="1">MSRLAVPRVSLYSSLHGSPRTPLRAIESPCRILPVFRASRPQCSPQAVRSFSISPQLHKKAGKANKSHARTDSSPPISKAGAFTPTDEAYDVSGLEAQILQAIEKLTHELSQLRSGGKLNPDIVESLKVQLGTASHGKESVRLGDIAQVVPRGRLLNVICGEEGHIKPITTAIAASPHSLTPLSPEPSNPLTIQVPLPPPTGESRRAAVEAAVKAAERADRHIQQARQEHNKKLRKFDVNREVLPDDLQKAKKMMEDVVKKGHIEVKRISDGAKRVLESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0J5A8</accession>
    <name>R0J5A8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_178389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022831.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19401609"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018149_3_1_1"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA92080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="357" mass="40138" checksum="866A119B3667E1E6" modified="2013-06-26" version="1">MPYSPNLAAENQAALDHFIQLPVSSDMISYLAQKATQVIRCEPSINKNLPPTPPASPQHMATNSREPALPSVEEFITSIVERSHVQTATLMSSLIYLSRLRSRLPPVAKGMRCTVHRIFLASLILAAKNLNDSSPKNKHWARYSSVRGYDNFGFSITEVNLMEKQLLFLLDWDLRINTDDLYYHLEPFLAPIRVWQSRQAEKARLAEKERELARKQYQRSTESLSRSVHAYPSNTSMSSYASRPQRHRMQYMPSARAPSRTPSLSPPTRSSSASVSSTSPASFHDEPSEAVVHRYDADQGANVVYINGPIPYTQPKQQHALPLYEHQPSKKAKTSAGGIFSRMFGQTATFTGRQTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0JHR9</accession>
    <name>R0JHR9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_124302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031520.1">
        <property type="nucleotide sequence ID" value="XM_008033329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JHR9"/>
    <dbReference type="STRING" id="671987.R0JHR9"/>
    <dbReference type="GeneID" id="19395939"/>
    <dbReference type="eggNOG" id="ENOG502SF4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035048_0_0_1"/>
    <dbReference type="OrthoDB" id="5338512at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353531" evidence="3">
        <location>
            <begin position="29"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA80938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="439" mass="47326" checksum="92F11AF13242AB20" modified="2013-06-26" version="1">MAPITVSPRLSRIPLVCLAFLFITTTQASALFLRQAETCAGKSDLQQCGSDFPSSFCCPKDSTCMGLNSGSVKSVICCPAGSDCSYIQPTTCDVTQLNATLHPDNQMHLSKTEGIELPKCGDKCCTLGYTCQSNMCAKDTSPKPSPSSPSTATPSSTSPASASQTSDCPASSPVETKRSFSVRSFVAGFFPGLIVGALSTLALLWVIRKRRETQAKSRYSGDFGHVARQISDPIYDPQHAARTDFMRRGSRSARSSPNTINKVVQGMKETNNNTAAHGFTPRIKSMWERTPKLNFGFTASLPANPAPPAVRAGNPYNDPYQTPPPKPKRIHSARRTSSRRTSALPPHVQVRPSAVRTTSSETIDVLMPSSAAATSGNAVYPANHSNDSGFLQPPQAPGMRGANRYTADSAHTTFTKLMERAGFDEGPRQEVRDWRTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJJ5</accession>
    <name>R0JJJ5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_165956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030948.1">
        <property type="nucleotide sequence ID" value="XM_008032757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JJJ5"/>
    <dbReference type="STRING" id="671987.R0JJJ5"/>
    <dbReference type="GeneID" id="19399643"/>
    <dbReference type="eggNOG" id="KOG3351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035272_3_1_1"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="215"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="411" mass="44785" checksum="5120A5CEE7E67F41" modified="2013-06-26" version="1">MPPPPSTPLHHRALLLLPPAPAPPSYAALRAAYNAPVCTVLKELAATQRTAQGPTLVEIALPCPHLYRQLDAPRGPHYATTQQLVAGLYKLICLAASRDAIDTDDEDAIDARVVLVAYPRDGQLTAPLADATPEQELQGPAVDMHTLARSPRAWDTVYSVESEEGEQVLRAFGSLSKSQYAVKKVRGGIVSVDASEPGPCHDQAKATTNHLSVAVGGTFDHLHIGHKLLLTMFAFMLGRRQASTPETSPSVLTVGITGDALLKNKKFAQHLQSWKDRQESVHNFLSSLVYFGSPDDERIHVEEIKEAGPNGHAVHVTYPLGLTIKYVEIWDPFGPTITDKDISALVLSLETRSGGAAVNQKRDEQGWGLLEVFEVAVLDASEEDKVDETFQSKLSSTEMRRKRSERTRCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJY4</accession>
    <name>R0JJY4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_35438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA83448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008030634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQK0"/>
    <dbReference type="STRING" id="671987.R0JQK0"/>
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    <dbReference type="eggNOG" id="ENOG502SJDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
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        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343985" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA83448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="374" mass="42016" checksum="E2F122B197E9B316" modified="2013-06-26" version="1">MVALNFRILYALLASLTLLHVVVARDLVTDLVRRGRPAMNAAIANSTTCTKEKLRIRREWGDISAREKRAYIAAVQCLIKRPSQLDPVQYPGAKSRFDDFIVIHMKYTLRIHGTGNFLSWHRYYTFAYETALRTECGFNGTQPYWHWGRYADSPETSPLFDGSDTSIGGQGKFVPHNSSTVRPAGRGGGCIDSGPFKGLMINLGPVGMIDYPKPTNNSRADGYGYNPRCVTRDISNYLTSRYTRTPQIAALILNHTTIGDFQDTMQLRTGVHGAGHFTVSGDPGSDFYTSPGDVHFYFHHAMIDLVYSTWQSLDFPHRQQVIAGGTRMFDDANNSTRQTLEDVVDLEVLNVDGKKYKIKELVSTVRGPFCYLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0JRK4</accession>
    <name>R0JRK4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_155111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028253.1">
        <property type="nucleotide sequence ID" value="XM_008030062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JRK4"/>
    <dbReference type="GeneID" id="19397481"/>
    <dbReference type="eggNOG" id="ENOG502S13F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038839_2_0_1"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA83748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="373" mass="41628" checksum="5347375C580244AC" modified="2013-06-26" version="1">MNDDTVTLTASCLCRSQVHSATVPKSSLPLQAHICHCNTCRHLTGSLHTSLAFWRSPRSTVDLSNFQTFSFSPAFEMLFCPTCSSPIFGAFTDKTRPLGVVTGALDNIATEPEVVRWNDMGFVADTLDGGASLWLRNVNVSGPALKCFQYERRGDNAKEVPEEWYTQQHTIQSTTERNAAVSIRCKCHGVHFLLRRGDYENMSADDLPWNVDPDSRKLKAELCGCDSCRLQNGTDVFYWTFAEMKNISFAGDNDEAGFPLHMDDLTTLVDQRDPRIGSLTYYQSSARVHRYFCRDCSATIFYANSNRPRIIDIAVGVLEAKEGARAEGMLAWSFGTGVGTKEDANGGWRQGVFERIAKAVEEYGKKQDSMEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0JT52</accession>
    <name>R0JT52_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_21614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028043.1">
        <property type="nucleotide sequence ID" value="XM_008029852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JT52"/>
    <dbReference type="STRING" id="671987.R0JT52"/>
    <dbReference type="GeneID" id="19402461"/>
    <dbReference type="eggNOG" id="ENOG502SC34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059403_0_0_1"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
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    </evidence>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        </source>
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    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
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            <topology evidence="4">Multi-pass membrane protein</topology>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="179" mass="19953" checksum="72F6539716FB6E77" modified="2013-06-26" version="1">MEVIQKVPVLRMMSRPTAAPVNPPPQPPAENAYTGTPITSPRSLRQLSIYFLGSACLLASTAITRKAIWRRQLRIKPKFYDANTNPHEYFSPFSDACQALNLATMNCVSVGIMALGGAMWTFDIANLKEARAVLRSRLNYDRIYESEDKIPNTISEMIAASGQMRIIEEDVKDGSEKSQ</sequence>
</entry>
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    <accession>R0JW50</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JW50"/>
    <dbReference type="GeneID" id="19404027"/>
    <dbReference type="HOGENOM" id="CLU_1023654_0_0_1"/>
    <dbReference type="OrthoDB" id="3792140at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="272" mass="31286" checksum="917FB06249BBCA88" modified="2013-06-26" version="1">MDSSKQPATYQDWYDWHANINPEQESLLFHEDKLRLITENNLVDIFNASYDIQWNNLVERLRDVESPALLFDGHETLRERTYSGTTVIRVVPAIALIAVSLNNYVARCNLPFKFSWSHVSRSSHEGDLYMSFGAWPAEEREVWMSTSPGFRAKRCTVWESTIRSSSQAIRISYARRLTGLQIGTLTCGQLLFQWGNTKAHKGQCTTSEKLYEMLCRYYLASTSRKPWHDWSVEALAAIHKERGAGEKYVTSFWGKVKKKMDGSDAVPAMKEK</sequence>
</entry>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0JWD5"/>
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    <dbReference type="eggNOG" id="KOG4173">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA80917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="278" mass="30785" checksum="EDC9AF644C2F5EAE" modified="2013-06-26" version="1">MASNPPNPPPLSPAYPKSRLLRSIARHVSAPIDPSVRESEHHSSPTPKTSLLPPTSKHSLLSELSLAQSVASRLRRDRDTWRTLAAERAQDLESTYQSLQEQARMLSSILERSLKLQAECKATTKSTAKLYSQVTRFKTKHEKLIADLNDAKCTIVRLRRSDRSKDKVQQQNLRLKALLRICSLKGSTAVATSTHPVTDAETALREALGLALERIDDLEGSGSVLLDELEKHNDNGDDDAAESGTRLIEAQVVFRSILDDGFCKEQKESWGALVEKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908659">
        <property type="protein sequence ID" value="EOA85683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_008026690.1">
        <property type="nucleotide sequence ID" value="XM_008028499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXP9"/>
    <dbReference type="GeneID" id="19403315"/>
    <dbReference type="eggNOG" id="ENOG502SPRR">
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    <dbReference type="HOGENOM" id="CLU_084275_0_1_1"/>
    <dbReference type="OrthoDB" id="4831122at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342945" evidence="1">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85683.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="252" mass="27568" checksum="BE7FB82288386E44" modified="2013-06-26" version="1">MLLTQWLAFVASATVVTAAPAPAAGSGDIVITADDVVLHGNGRIQVMKRSEFKGLFGDYHAILANQTRHDANKVEHTEAQLNELKRNAKTKRDDRVILIPGRTDKFLDYDVQMSQIVKGIAGTGTRITIASGYSITNSLSINGGAEFNFVEDFFSASVDLTMTWETTSTQSQSLFADVPPGKFGCWVSNPLNTRTYLNIWKGQIGSPGSLQEVYVNKFTSRQYENLAWVDGLLQLCIGDQSPLPRCLGTGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXZ3</accession>
    <name>R0JXZ3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_111294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908637">
        <property type="protein sequence ID" value="EOA85793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026585.1">
        <property type="nucleotide sequence ID" value="XM_008028394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXZ3"/>
    <dbReference type="STRING" id="671987.R0JXZ3"/>
    <dbReference type="GeneID" id="19395477"/>
    <dbReference type="eggNOG" id="ENOG502T17B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068279_2_1_1"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="253" mass="29117" checksum="C52419BB78396281" modified="2013-06-26" version="1" fragment="single">VTLKVGPELKKFRVHKALLLKHSEYFRKALRGSWTEAKEGVVKIDDIEPAVGMLLSLNIFVHWLYTQSLPKPCDYKEWSGFGGSAVTVNKLRAYIFADRFQIPSFGQAVHNNLVQELQDQSLAICEEYNLSLITEAYDGLPTESPILQLLVDTLCEKRKACAHQGPDDINKLPPAFLARVVRNMLHSQHHRQQKQVAMKYRCYYEHATEMSLRACNTRKTHMKFNHEKEFGFFGLCGYCEESNTSDFKCDFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZL5</accession>
    <name>R0JZL5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SETTUDRAFT_121460</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029887.1">
        <property type="nucleotide sequence ID" value="XM_008031696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZL5"/>
    <dbReference type="STRING" id="671987.R0JZL5"/>
    <dbReference type="GeneID" id="19395849"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="113"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EOA82899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="509" mass="56632" checksum="3DD4FDB12CD3408B" modified="2013-06-26" version="1">MNRDSNNTQQQKLSGEHVAAHNNADSCWVIVHGRAYDVTEFLPEHPGGSKIILKYAGKDATEAFEPIHPPDTLDKYLDQSKHLGEVDMNTVQQDEKELDPDEEARQKRIERMPILEQCYNLMDFEAVARNVMKKTAWAYYSSGADDEITLRENHSAFHKIWFRPRVLVDVEKVDTSTTMLGTKCDIPFYVTATALGKLGHPEGEVVLTRGAHKHNVIQMIPTLASCSFDEIIDAAKDGQCQWLQLYVNKDRAVTKRIVQHAEKRGCKGLFITVDAPQLGRREKDMRSKFDDVGSNVQSTGGDNVDRSQGAARAISSFIDPSLSWKDIPWFRSITKMPIILKGVQCVEDVIRAVEIGVDGVVLSNHGGRQLEFARSGVEVLAEVMPVLRARGWQDRIEVYIDGGIRRATDIIKAVALGAKGVGIGRPFLYAMSAYGLPGVDRAMQLLKDEMEMNMRLIGASSIADLNPSMLDTRGLSMHTAPVPHDTLGLNVYDPLVGPQEKVVKEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0K002</accession>
    <name>R0K002_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted in xylem 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_34559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030087.1">
        <property type="nucleotide sequence ID" value="XM_008031896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K002"/>
    <dbReference type="GeneID" id="19403921"/>
    <dbReference type="HOGENOM" id="CLU_950087_0_0_1"/>
    <dbReference type="OrthoDB" id="5475247at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344151" description="Secreted in xylem 13" evidence="1">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32060" checksum="E36D0FFF72A6C405" modified="2013-06-26" version="1">MVSFTRILGLLTISYFQSCSSVYAELARWVSVEGNSTISLPFNETALLAVLTPNNYTTRSLTKYDVNDPLSKRVVDAYDPALHPNGRCPISSFYVPHNDDTMCDAQFHIGADASYASQSSSCSRSIFRRLHCQLCAGRNIRNPSEIKYYDTQCGKNQVCTQDSPRWNSWGRLEPQSYCHDANTLVELAVAKGATLREYCSQKFRFPKAGSGKTATFHAWLYDTVSGLRQPAQWIYLKVNGAYARAVQSSEDWTTKFPIDSGSSCEMCIFPFNTDYDLELDWSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0K174</accession>
    <name>R0K174_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_93976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029144.1">
        <property type="nucleotide sequence ID" value="XM_008030953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K174"/>
    <dbReference type="STRING" id="671987.R0K174"/>
    <dbReference type="GeneID" id="19406071"/>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="134" mass="15337" checksum="15A5543003C94749" modified="2013-06-26" version="1">MADSQVTLRTRKFIRNPLLGRRQMVVDVLHPNRANVSKDELRGKLGELYKAKKEDVSVFGFKTHFGGGKSTGFALIYDSAEAMKKFEPRYRLVRYGMATKVEKASRQQRKQRKNRMKAFRGTAKAKGGAKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1C4</accession>
    <name>R0K1C4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_164841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025614.1">
        <property type="nucleotide sequence ID" value="XM_008027423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1V8"/>
    <dbReference type="SMR" id="R0K1V8"/>
    <dbReference type="STRING" id="671987.R0K1V8"/>
    <dbReference type="GeneID" id="19398673"/>
    <dbReference type="eggNOG" id="ENOG502QRGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005987_0_1_1"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA87113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="967" mass="109688" checksum="5BB23426D24A8F60" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2W9</accession>
    <name>R0K2W9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_32968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028091.1">
        <property type="nucleotide sequence ID" value="XM_008029900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2W9"/>
    <dbReference type="STRING" id="671987.R0K2W9"/>
    <dbReference type="GeneID" id="19403719"/>
    <dbReference type="eggNOG" id="KOG3045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027694_3_1_1"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA83959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="571" mass="62271" checksum="6EF6A810C7E8A6BF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>R0K365</accession>
    <name>R0K365_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">SETTUDRAFT_165216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029823.1">
        <property type="nucleotide sequence ID" value="XM_008031632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K365"/>
    <dbReference type="STRING" id="671987.R0K365"/>
    <dbReference type="GeneID" id="19399390"/>
    <dbReference type="eggNOG" id="KOG3846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_4_0_1"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="121"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="171"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="505" mass="56288" checksum="397E52A8959B8921" modified="2013-06-26" version="1">MPYLHNPYLAIPEAKLCAEQFSQREDAKDGLSKLRSEFVIPTKGDLKARKYGFQHKEKRATAQSQDDEESIYFCGNSLGLQPRRTKEYINRYLDTWASKGVFGHFTNYEGGLPPWLHIDDAVKNQTAKIVGALPNEVVIMETLTANLHLLMASFYRPTKDRWKIIIEGKAFPSDHYAALSQIAHHNLDPSALITIDPPSASAPYLSSEHILSVISHHAPSTALVLLPGIQFYSGQFFDIELITRHCRSLGITVGWDLAHAVGNVPLKLHDWNVDFAAWCNYKYMNGGPGVIGGAFVHESHGKVEQVPTNQTNGTGSSSNRDTSLSYRPRLSGWWGSDKNSRFRMDNKFVPIPGASGFQLSNPSALDMTSVMASLDVFALTDMEALRQRSLNLTAYLEARLLKYPNGEPPYKIITPPNPAERGAQLSILLKPGLLDQVLHYIEERGVVVDERKPDVLRIAPAPLYNSFRDIHRFINIFHEACRIATRGAGDKRPHNNAVPKGIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3I4</accession>
    <name>R0K3I4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_66845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029528.1">
        <property type="nucleotide sequence ID" value="XM_008031337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K3I4"/>
    <dbReference type="STRING" id="671987.R0K3I4"/>
    <dbReference type="GeneID" id="19405329"/>
    <dbReference type="HOGENOM" id="CLU_013929_2_2_1"/>
    <dbReference type="OrthoDB" id="5425161at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="182" mass="20213" checksum="1EB2C813D1857DEB" modified="2013-06-26" version="1" fragment="single">LITGSEGYRKKKRIQPGNREWVTVIQGVGASGRRIPPFVVFAGKVLINLEHFNTHTKSSTVGRYQLLIIDGHESHCSIDFQDLCKEKNIILLCMPPHSSHLLQPLDVACFSPLKRKYGDAVSGLARNRTHYISKENFLPAFKAAFEQSITKENIQAGFRGAGLVPHDPQAVLSKLDVVVQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3U6</accession>
    <name>R0K3U6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_130624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024642.1">
        <property type="nucleotide sequence ID" value="XM_008026451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K3U6"/>
    <dbReference type="STRING" id="671987.R0K3U6"/>
    <dbReference type="GeneID" id="19396114"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_5_2_1"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA87763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="400" mass="45335" checksum="CC58FC2427E3398D" modified="2013-06-26" version="1">MAEQRVAKRKTHTKSRKGCFQCKQRHTKCNEARPRCANCVRLDIHCTFPTVPGSYSTPQPPISGANSPLAEPFAAESPAAAQSSPELPLADLKLLHHWTTTCAMSLHPNPAKRSAFWKEEFVELGFEHPFLLRGFLALSAVHQASLLPTKDRQDLLLQADSHISRALDTYRKNLETPKLELALPMFLLSSVLLTYNFGSALLEQPEDPISALHHCFMLLQGIKVVVMPHWDQLKDTVIFEQMTDLSNQEDLRALDELAGDDRPQEILRLNELTELLLDSQDKEVCAKAIDSLHNIYVRFRHLPPDRDEYSLLFVWSAQLSSHFLDLLAAHNPVTCIITTHFVALLAQSREVWWVSKWPRWILAASELLLAATPDLLQWLEWPRSIIGQQIWSSTPTPATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4I1</accession>
    <name>R0K4I1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_172923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029010.1">
        <property type="nucleotide sequence ID" value="XM_008030819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4I1"/>
    <dbReference type="STRING" id="671987.R0K4I1"/>
    <dbReference type="GeneID" id="19401220"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_6_2_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="6"/>
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                <person name="Han J."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="KB908659">
        <property type="protein sequence ID" value="EOA85624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026707.1">
        <property type="nucleotide sequence ID" value="XM_008028516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K844"/>
    <dbReference type="STRING" id="671987.R0K844"/>
    <dbReference type="GeneID" id="19400977"/>
    <dbReference type="eggNOG" id="KOG0636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_0_0_1"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfate adenylyltransferase"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
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        <property type="entry name" value="apsK"/>
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    </dbReference>
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        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="176"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="397"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="397"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="436"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA85624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="575" mass="64235" checksum="A69878906554C95F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8F0</accession>
    <name>R0K8F0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_26456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022870.1">
        <property type="nucleotide sequence ID" value="XM_008024679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8F0"/>
    <dbReference type="GeneID" id="19403022"/>
    <dbReference type="HOGENOM" id="CLU_1994016_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="125" mass="13530" checksum="431388777408D82F" modified="2013-06-26" version="1">MRREAHQAQEHTDADSGLNSDSGPSRLSPQKRLARPRRHRDHDHDDHQRPADQRATAQAINNAAVALHCHGHGQSQYHHMHTTATATPIPDQQVPLPGSTATLQLSPKAADGGGRDCKVVADPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9X0</accession>
    <name>R0K9X0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_90128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027524.1">
        <property type="nucleotide sequence ID" value="XM_008029333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9X0"/>
    <dbReference type="STRING" id="671987.R0K9X0"/>
    <dbReference type="GeneID" id="19405817"/>
    <dbReference type="eggNOG" id="ENOG502R6QN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003836_1_1_1"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057215">
        <property type="entry name" value="DUF7893"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF54">
        <property type="entry name" value="DNA METHYLTRANSFERASE DIM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25423">
        <property type="entry name" value="DUF7893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="10">
        <location>
            <begin position="333"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA85032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1012" mass="115004" checksum="6F2F06370DAF7653" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KB06</accession>
    <name>R0KB06_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_114943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025237.1">
        <property type="nucleotide sequence ID" value="XM_008027046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KB06"/>
    <dbReference type="STRING" id="671987.R0KB06"/>
    <dbReference type="GeneID" id="19395636"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA86574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="492" mass="52565" checksum="42D7990A5B9929A9" modified="2013-06-26" version="1">MSNIKVVKPDPAYTVPLLINGKEVTTQTTFAVTSPASHQQIWNSSSASLDDVKSAVSAAKAAFPAWSKMKHSAKRDIFLRAANVVEARTDELADYMKMETGAADMFSNGFNVPKMADMLRDVAGRISAVMGHIPSCEEEGTSALVVKEPYGVVLGIAPWNAPYILGMRAILYPLAAGNTCILKGSEFCPRTWWALGSVLSEAGLPAGALNVLVHRPEDAAQITKALIEEPAIKKLNFTGSTAVGRIIASTAGQNLKPVLLELGGKASAIVLDDANLQTAAVQCALGAFFHAGQICMSSERILVHKAIKPQFLEAFKGAVEGIFGGDKPAPILVAAPGVQKNKRLIADAVKNGATVVQGDHEKDEKHPDTNEPSATRMRPVIVDGVTKSMDLFHTESFGPSVSVIEISSDEEAVEIANDTEYGLSGAVFTENLGRGLRIAKQIESGAIHINSMTVHDEWTLPHGGAKSSGFGRFNGQWGIEEFVRMKTITYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBH8</accession>
    <name>R0KBH8_EXST2</name>
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        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_41294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBH8"/>
    <dbReference type="STRING" id="671987.R0KBH8"/>
    <dbReference type="GeneID" id="19404687"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="508"/>
        </location>
    </feature>
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        <location>
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            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA86744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="56127" checksum="A72361C5231E4CFA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBI0</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908670">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBI0"/>
    <dbReference type="STRING" id="671987.R0KBI0"/>
    <dbReference type="GeneID" id="19403317"/>
    <dbReference type="eggNOG" id="ENOG502SPYJ">
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    <dbReference type="OrthoDB" id="5429780at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="99" mass="11217" checksum="1EB42ADD17A22C49" modified="2013-06-26" version="1">MNDYGEDFDLASLECSLEAYLIKRVTQACNDVLAAGDGDGDNWTEAMTATGIITKELQYAIIDEELETIRGTQSLQAWLAEIFGKYFRTFEYMDEILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KC90</accession>
    <name>R0KC90_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_87922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <strain evidence="3">28A</strain>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="11">28A</strain>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="nucleotide sequence ID" value="XM_008026410.1"/>
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    <dbReference type="eggNOG" id="KOG0254">
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    </dbReference>
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    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS sugar transporter, putative"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
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            <end position="30"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA87709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="508" mass="55488" checksum="5EB5435680D8CE00" modified="2013-06-26" version="1">MALPPKVYQFLVGLFASLGSLLYGYDLGVIAQVIASKAFIREFNQPDDNATGAVVSVFTGGAFFGAAFAGPAGDKFGRRITILMGALVFILGGSLQTGAQSLSYLYAGRVLAGAGVGFLVMIVPLYQSEMVHPSIRGRVTALVQFMLGIGALAAAWISYGVDIGFADDNNGQWRTSLGIQVVPAVFLAALIMVFPESPRWLISKGKSEEGLRNLAKLHANGDETDAWVLAEYDQIQEAISFDREHEAQSYLDLFKDRSCFRRLFLACAIQASTQMTGVSAIQYYSITIYHQMGISSTDALKYQAISSVLALCGQALCIAFIDRLGRRWTLIGGNLGNCVTFIIATVMLAVFPPGSTGNAAASWGFIAVTWAYNFCFSSTCGPLSWIIPAEIFDTKTRSRGVSIATMTSFAFNTMIGQTTKPGMENIGWRFYLLFVICNFTNAIFFYCFLPETAKRPLEEMNYLFTNAPLLVPGMNKREWALDIERRVEEVAAKQGSISHTEHAPELKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEH7</accession>
    <name>R0KEH7_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_30881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEH7"/>
    <dbReference type="STRING" id="671987.R0KEH7"/>
    <dbReference type="GeneID" id="19403480"/>
    <dbReference type="eggNOG" id="KOG2084">
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    </dbReference>
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    <dbReference type="OrthoDB" id="438641at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="378"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="659" mass="73032" checksum="EE4DD7C9A6CCF8B4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFM9</accession>
    <name>R0KFM9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_27576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA88114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025859.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0KFM9"/>
    <dbReference type="GeneID" id="19403146"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019364_0_0_1"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
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    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="128"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="376" mass="41372" checksum="46776AEB9B23677F" modified="2013-06-26" version="1">MVKLTQQPWKGIYALGAVGFELLRFPYFVVAYLVASRRQNPTWSFRQAIGVRFLASALWHVATLQLQEPLPLTPGAEKERFVLVKPGKDEAYKGPLRNSKDVVPAEIGGTWYPAPLTPGSDKSNVKVILHTHGGAFVHGDGRSGATGFLTSLFLKHTPATHVFCPQYRLAKLPVSSSSDPFPAGLQDVVTSYLYLVHDLKVPAENIIVSGDSAGGNLTISLLRYIAEFGAEAGLPSPAAGLLWSPWIDTSDNKAEYARTNRNYMSDYLSPPFTVWATEAYAGPAGESVLSQPYVCHKNSMFKTQVPIWINTGGAEILYFDDVEWAEQMKKAGNNVELDIEDNVPHDIILLGNTLGFEKEAVGMAERVGKWIKEYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0KG56</accession>
    <name>R0KG56_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_168651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
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    </dbReference>
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        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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            <end position="147"/>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="227" mass="25852" checksum="BC1B83155C26F545" modified="2013-06-26" version="1">MPPALSDHESSDAEEVPPTRTQTKKPVEEDAVQDADEDEDEDGSDVGEDEYVVEAIYGHRFQKGVLQFDVKWDGYDDPKDRTWETEDNMEGAIDVMNEYFAKIGGRPEPKGQKRKGRPSISGTKSASGTPTASSKRPKSEKAHRVEKAWSPPPGSWEHDVSYVDTVEEMRDPKTGELGKFVYLVWLNQQKTQHPLKHVYQKCPQKMLQYYESHLVFTHTTDEPPNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_87572</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502T5KC">
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    <dbReference type="OrthoDB" id="3790619at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="66" mass="6993" checksum="7637D7360A0CB6CB" modified="2013-06-26" version="1">MSSPAPQYVYVPNLVGGQMLRLPVEDPSADGQASIAQQPIASPTLSSRYTRDSSPSPSVESVESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGU6</accession>
    <name>R0KGU6_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_153071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021020.1">
        <property type="nucleotide sequence ID" value="XM_008022829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGU6"/>
    <dbReference type="STRING" id="671987.R0KGU6"/>
    <dbReference type="GeneID" id="19397253"/>
    <dbReference type="eggNOG" id="KOG0592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_44_0_1"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
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        <location>
            <begin position="171"/>
            <end position="441"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <position position="200"/>
        </location>
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        </ligand>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA92078.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="744" mass="82708" checksum="67E99CFE4872B28A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KHB2</accession>
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        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0KHB2"/>
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    <dbReference type="OrthoDB" id="47007at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
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    </dbReference>
    <dbReference type="GO" id="GO:0006633">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="301" mass="32155" checksum="4F96DCE87E1417F6" modified="2013-06-26" version="1">MDARPAHTRTASTNLSASGQRILEGRTAIVTGASRGIGLEIARNLASKGCNVVINYTSDSSAQAAQNLADELQNDYGVKAITVQASMGSENGPKHLVEVAKNNFQHPKTGKFQLDIIINNAGVAGNNYVENVDCEDFARQFNVNVRGPLLLVQAAIPYLPNDRSGRIVNLSSVSSSLGYKGQSIYGATKAALESMTRTWSRELAERCTVNAINPGPVATDMYWSNDDAFIALNKPFIENTPLAATRKGIDPERIYEASQNAGGRPGYSEEIAGIVGMLCLPEAGWTTGSVMCANGGMKFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KHC5</accession>
    <name>R0KHC5_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_163387</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        </location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA88889.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="74577" checksum="2EE20C171E2592A4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJS4</accession>
    <name>R0KJS4_EXST2</name>
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        <recommendedName>
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            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
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    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA89434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="468" mass="51281" checksum="59A7B0BC4611EAF3" modified="2013-06-26" version="1">MEAITNKLQTVMGTASGPYSGKTALLLGAGFVTRPTVEVLAKSGVKVTVACRTLEKAQSLAKGIPNTHAISLDVNNADTLDAEVAKVDVVISLIPYTFHATVIKSAIRKKKNVVTTSYVSPAMMELDAQAKEAGITVMNEIGVDPGVDHLSAVLTIDEVHKAGGKILSFKSYCGGLPAPEASDNPLGYKFSWSSRGVLLALRNQAAFYQDGEVKSIEGPELMAEAKPYFIYPGYAFVAYPNRDSTPYKERYSIPEAQTIIRGTLRYQGFPEYIKCLVDIGFLSEEPKDFLKEGEKRTWRDATAQIIGAQSSKDEDLIWAISSQTKFASTEDKDRIISGLRWIGVISDEEIIPRGNPLDTLCATLEKKMQYEEGERDMVMLQHRFEIENKDGSKAVRTCTLVDYGDPKGYSAMAKLVGVPCAVAVQQVLDGTLSEKGILAPMTPEICKPLMKTLEDQYGVYFKEKTIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJW2</accession>
    <name>R0KJW2_EXST2</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_168660</name>
    </gene>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA88297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJW2"/>
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    <dbReference type="eggNOG" id="ENOG502S8VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019366_3_0_1"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="464" mass="52714" checksum="1069860292D01B66" modified="2013-06-26" version="1">MPELLDLCYDVLVQILEEINPEDLAACAQASKGFGDFIRENTRIYKTVYLKHFDDPRRRRPTDPEPEWVEALQRTVKCQKMLLSADNDLKRDEFNYIASTVDNLLGTMSLDDLGTSRNKTLITDLFLNISQNHDAFMCRSSLFERAGTAKQRPADDEEGRQLSAKLHSFFGFPPSGAGTKDLATHPYARSRVYDLRNYTDQNEWGPFRKDGSMRVDWEMVESIMIVVGHNSFFGAHNVPNPLRPPWFHPLDGVIPDVPVDAGQAMPDYMALLKQPDLPLDMKDPYRVQGIWSRIVCFLDYTDLYHYNFDSEARRMPADEPRAPLITEEATRHILMNLQVTDVTAPGPFEDPSMPIVHFRGKSKSVDAQWDPNANSGIRGTVRMTANGDIRWKTISVFHGGEERWRSDGVQIGGLRSPRGVVGTWFDKDFDIHGPAGPTVFWKISDKILEPSENDSDSGENFWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKG2</accession>
    <name>R0KKG2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_176550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023883.1">
        <property type="nucleotide sequence ID" value="XM_008025692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKG2"/>
    <dbReference type="STRING" id="671987.R0KKG2"/>
    <dbReference type="GeneID" id="19401478"/>
    <dbReference type="eggNOG" id="KOG4504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064145_0_0_1"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="30"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="332" mass="36769" checksum="697BCBDEAF1B6128" modified="2013-06-26" version="1">MGQMIRDDGGNAATLCLRNTLASGAARPIAPCRDTGPQRLHPHPASPAKTAMASNEGSWHARGYDYGANFTINFCGPVVEELDEVQDLDKALWKNVSAFYEKGSKQWAIGLESSEPIFRGRKLILNYTGGSLCPSSSSKSKRALAPVSLDTREIIDGDDDDKGKGDKDKDKKKKEPERRKTTVISLLCDSDPLAKTSISFVAAVDECAYFFEGRSPFACGGVHQEAQALSPGGVFGVMVTIAVLVYFAGGCVYQRTVMHQRGWRQLPNYAMWAGIWRFFTDMFVILTSSCARFMPSRRGYSRVSLGQDNARRGRRNEDEDRLIDNLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLK2</accession>
    <name>R0KLK2_EXST2</name>
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        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_145461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021959.1">
        <property type="nucleotide sequence ID" value="XM_008023768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLK2"/>
    <dbReference type="GeneID" id="19396807"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_1_1"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021263.1">
        <property type="nucleotide sequence ID" value="XM_008023072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNQ1"/>
    <dbReference type="GeneID" id="19404097"/>
    <dbReference type="HOGENOM" id="CLU_1950155_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="129" mass="14270" checksum="928F4A322551CD5C" modified="2013-06-26" version="1">MWSRVWTDALVEGLPRRPRQGLDVPPDGGPGRALMTMWLRRQIMRRQFATQTERVHTLALGYEPSLRNPDQGEEDENNDNMQAGGCLADLTTPVGFLMAAIAQPWEPAQGGLDCAASRRVGGCWPISQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNQ9</accession>
    <name>R0KNQ9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_36198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021264.1">
        <property type="nucleotide sequence ID" value="XM_008023073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNQ9"/>
    <dbReference type="STRING" id="671987.R0KNQ9"/>
    <dbReference type="GeneID" id="19404098"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA90689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58376" checksum="10DBF71CD4CF10B5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNU5</accession>
    <name>R0KNU5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RuvB-like helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_166656</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021498.1">
        <property type="nucleotide sequence ID" value="XM_008023307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNU5"/>
    <dbReference type="STRING" id="671987.R0KNU5"/>
    <dbReference type="GeneID" id="19399886"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="66"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA90739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="462" mass="49913" checksum="36A4DCAA6E2D8271" modified="2013-06-26" version="1">MTTVPVSEVKSTHDRSSRTAAHSHIKGLGLSSDGRATPSAGGFVGQAAAREVCGLVVDLVKAKKMSGRAVLLAGGPGTGKTALALAVSQELGTKVPFCPIVGSEIYSAEVKKTEALMENFRRAIGLRVKETKEVYEGEVTELTPEEAENPLGGYGRTISHLLITLKSAKGTKKLRLDPSIYEAIQKERVRLGDVIYIEANTGAVKRVGRSDAYATEFDLEAEEYVPIPKGDVHKKKEIVQDVTLHDLDVANARPQGGQDIMSMMGQLMKPKKTEITEKLRLEINKVVNRYIDQGIADLVPGVLFIDEVHMLDLEAFTFLNRALESPLSPLVILASNRGNTHIRGGENLPPSAHGIPTDLLARLLIIPTHPYSPAEISSIITTRVTTEKLNISAAAKEKVSSLGEKISLRYALQLLAPASVLAEVNGRENKQIEVEDVDECQGLFLDARRSAQALGETSGFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPY0</accession>
    <name>R0KPY0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_36559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021317.1">
        <property type="nucleotide sequence ID" value="XM_008023126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPY0"/>
    <dbReference type="GeneID" id="19404151"/>
    <dbReference type="HOGENOM" id="CLU_2251721_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="104" mass="11650" checksum="881E0685E3F21C33" modified="2013-06-26" version="1">MNTPPRSESPNALSRHSAIHSNEDRVDTPLESANGEAVNDYEHSDLASTEVSETDFDGSYEDEYEGSDFDLTDYGEDGYESSDLDLASPTIRRPRRVDLFTQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQP1</accession>
    <name>R0KQP1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_36769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021877.1">
        <property type="nucleotide sequence ID" value="XM_008023686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQP1"/>
    <dbReference type="STRING" id="671987.R0KQP1"/>
    <dbReference type="GeneID" id="19404182"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA90117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="472" mass="51568" checksum="0D5A2FFC5D822453" modified="2013-06-26" version="1">MGKEKIHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFESPKYYITVSEIHDKHVQPLTLYLVDAPGHRDFIKNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAINKMDTTKWSEDRYQEIIKETSNFIKKVGYNPKHVPFVPISGFNGDNMIEASTNCPWYKGWEKETKAKATGKTLLEAIDAIDPPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVTFAPAGVTTEVKSVEMHHEQLTEGVPGDNVGFNVKNVSVKEIRRGNVAGDSKNDPPKGCESFNAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFSELLEKIDRRTGKSVENSPKFIKSGDAAIVKMVPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVSKVDKAGKVTKAAQKATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSL1</accession>
    <name>R0KSL1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_24912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021216.1">
        <property type="nucleotide sequence ID" value="XM_008023025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSL1"/>
    <dbReference type="GeneID" id="19402854"/>
    <dbReference type="eggNOG" id="ENOG502SFC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115534_0_0_1"/>
    <dbReference type="OrthoDB" id="5278907at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="206" mass="24168" checksum="D61CF735D9190B75" modified="2013-06-26" version="1">MRREIRVRDAKKNVTQGTSQNLHRTPIKHTSSPPAVVASTRPANMLRILNRILGRQQNTLPPFDFARNKYRVKKKWPPNLRALTEKQQFRFERKFKRRIKLKSIRPEWNKWTKIVQWSLISFIVVYGVLFHDFRKDPMNPRPGEQPFEGLRQRMWRLFGGFYTQTENVMKGEGGVRGARRLERTEEEEEKVHGAAPLSSSSSSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0KU19</accession>
    <name>R0KU19_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_170245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020561.1">
        <property type="nucleotide sequence ID" value="XM_008022370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KU19"/>
    <dbReference type="STRING" id="671987.R0KU19"/>
    <dbReference type="GeneID" id="19401030"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="176"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="529"/>
            <end position="763"/>
        </location>
    </feature>
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        <location>
            <begin position="816"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="749"/>
            <end position="786"/>
        </location>
    </feature>
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            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="846"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91267.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="860" mass="96406" checksum="4D729FC1E233A739" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_133676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="226" mass="25169" checksum="C94B1FD5C4F377DA" modified="2013-06-26" version="1">MTDQIPKDVKAQVKASYDAIADTYNTVFTKPHEELRLDYLGRLVTSLQSYHQDTATVLELGCGAGVPATKFLLECSSPSFRITANDISTAQLSLARSNLASYADRLTLLEGDMLSLSFPPETFDAVTGFYSIIHLPRDEQTLLMAKIAQWLKPGGYLLANFSVAAMAAQVEDQWLGHDKGWMFWSGWGEEKSVEMVERAGLKVEVREVKQAEGDAVFVWVLARKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KWI9</accession>
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        <recommendedName>
            <fullName evidence="6">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_162591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA92072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008022825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KWI9"/>
    <dbReference type="STRING" id="671987.R0KWI9"/>
    <dbReference type="GeneID" id="19398445"/>
    <dbReference type="eggNOG" id="ENOG502RZMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027095_1_0_1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Putative lysine N-acyltransferase C17G9.06c"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
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    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="351"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA92072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="527" mass="59694" checksum="866C1B9648759371" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0I4Y2</accession>
    <name>R0I4Y2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_166180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031662.1">
        <property type="nucleotide sequence ID" value="XM_008033471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I6Q0"/>
    <dbReference type="STRING" id="671987.R0I6Q0"/>
    <dbReference type="GeneID" id="19397788"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA81151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="58279" checksum="D3B459500552BC91" modified="2013-06-26" version="1">MVSGANWRCTVSITTALLLGYIFIFRPIRNIFFHPLKKFPGPKLFAASSIPYGFWYMSGKWHNKIRQLHAIYGPIVRIAPKELSYATPEAWEDIYGRYVPAKRKENPKPTWYCSPDAHDMVGASLGDHGRMRRVMAPGFTYSAMCEQEPLIQGHVDLFLSKLHGLCDQGKSTVNMLEWFTYCTFDLIGDLSFGEPFGCLENSMLHPWQQLVFANIYVTHIILLCRRIPFFYLFLPIKTTLQLYRDFKRHVVLLRQVVERRLTLTTPRHDFLEIMTARRSTTLYMTKEEIFKNAILLTGGGAETTSSSLTGMAYILTTRPDVKQRLVEELHTVFAEEQDINMRSVAQLTYMGAFIEEAMRYYPPGPNTMWRTTPAGGNTILGEHIPDNTVLGIPHRVLYRSEAYWKHADEFHPERWLPDGQRPAEFDEDRREGFHPFSYGPRACIAMNLAYAEMRYILARFLWNFDIQGTEKSEGWMDNQKAYLVWDKPGLFVHLKPVAKEGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0I806</accession>
    <name>R0I806_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_24032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030629.1">
        <property type="nucleotide sequence ID" value="XM_008032438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I806"/>
    <dbReference type="GeneID" id="19402730"/>
    <dbReference type="HOGENOM" id="CLU_1994019_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="125" mass="13174" checksum="A1444272D22BCC53" modified="2013-06-26" version="1">MSGEAEYAIRGGAASRDHAGASASPEWLSMSMIDFLSRSRNGRTTCVMARAGDDGDLMLGRPPLRPGTSLPTHRPSARRPQAGSIARGVAKKQRLHAKALFHVDVATVDTSSGISMSSHPSFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8U9</accession>
    <name>R0I8U9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="14">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_181235</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="14"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030308.1">
        <property type="nucleotide sequence ID" value="XM_008032117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8U9"/>
    <dbReference type="STRING" id="671987.R0I8U9"/>
    <dbReference type="GeneID" id="19401834"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_3_0_1"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000456">
        <property type="entry name" value="3-ketodihydrosphingosine reductase tsc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA81945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="369" mass="40474" checksum="D75650487DBD9A34" modified="2013-06-26" version="1">MLMLLSLALGAVILVLAILWTTGIMVFSFGGRSHFPVDGKTVILTGSSQGMGGEIACLLAARGANLVLVARTEKNLKATVQRAKKCAKEPADQRFTYIAADVTSEAENARILREATAWNHGRMPEIVWCVAGSSTPGLFVETSTETLRQQMDLNYFATAYMAQKALQAWLYPEVPYHTRDKPTSPESPRKFIMTSSALAFVNIAGYSPYSPAKAALRSLADGLRSEVQLYNAARHSNVKADFTPAPFDVNIHIVFPGSILSPGFEKENKTKHPVSMELESADPKQTELEAAQSCLDGLDKGHFMTPTNWLVHLMRWGSLSGSEKNNWLIDAIGALVSVIAWWFIAPDMNRTVRGWGKKNGMPAFRPNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9G2</accession>
    <name>R0I9G2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_165525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030355.1">
        <property type="nucleotide sequence ID" value="XM_008032164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9G2"/>
    <dbReference type="GeneID" id="19399501"/>
    <dbReference type="eggNOG" id="ENOG502SN3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072123_1_0_1"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28004" checksum="FB3C76A6D582B1BC" modified="2013-06-26" version="1">MLNSLGTKLALRKAGLGNVSLPKTDSFFGSNNPSSKKGNAAADDAAAGFANPFANVQWGVPKALQSWQTPPPPQNPVRKPPQIGDRAQSHAKLPFPDASGRPTILLFLRFCGCPFAEKLLLRLRTLANRYPSIRFIAISHCTPDATRKWVNQLGGAWNVDMVVDSDRNLYALWGLGISTWAHVLHPRNGYNQVMLRRNEGVWGHEVGEGACRWQLGGAYAIDGRGVVTWGGPMESVDEEIRFEDGVKTLGFGDTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9Z3</accession>
    <name>R0I9Z3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_35025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030137.1">
        <property type="nucleotide sequence ID" value="XM_008031946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9Z3"/>
    <dbReference type="GeneID" id="19403971"/>
    <dbReference type="HOGENOM" id="CLU_1489881_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004352863" evidence="2">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="181" mass="19305" checksum="067F6191C1BDC4ED" modified="2013-06-26" version="1">MARTPCLSCAVSLVLVGRMAVAFCDFHMVTWPSRHLISVHSTALDAVPPASLSRAVGSELRVRAPHGLRAIRGPGCDTVPRLLSTYYTTLLPAVADVWFWILSPATSAWLELSPGNHASFSSRALRALARHPPATPPDPRGAAPPGTGTGTGTQHVHACIHTTTTTVLVCLAWPRLHAMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBJ8</accession>
    <name>R0IBJ8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_165098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 15"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027275.1">
        <property type="nucleotide sequence ID" value="XM_008029084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIF6"/>
    <dbReference type="STRING" id="671987.R0IIF6"/>
    <dbReference type="GeneID" id="19398801"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_0_1"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="563"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA84711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="983" mass="108011" checksum="1E8D79ADDEB68069" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIW3</accession>
    <name>R0IIW3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_163687</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027404.1">
        <property type="nucleotide sequence ID" value="XM_008029213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIW3"/>
    <dbReference type="STRING" id="671987.R0IIW3"/>
    <dbReference type="GeneID" id="19398850"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_0_1"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="54"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA84881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="525" mass="57769" checksum="18FFA70C2D440F96" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJN0</accession>
    <name>R0IJN0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_164009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027761.1">
        <property type="nucleotide sequence ID" value="XM_008029570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJN0"/>
    <dbReference type="STRING" id="671987.R0IJN0"/>
    <dbReference type="GeneID" id="19398968"/>
    <dbReference type="eggNOG" id="KOG1727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095877_0_1_1"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA85350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="169" mass="18975" checksum="F56E779567716612" modified="2013-06-26" version="1">MIIYKDIITGDEIISDSYNLKEIDGVVYEADCSKITIGGETFDTGANASAEEQEEGADDTVETKIDVVHSFRLNETGFDKKGYLTYLKGYMKAVKETLKTKGADEATIKDFETKAQGYAKKIITNFKDYEFFTGESMNPDGMIVLLNYREDGVTPFVTVWKHGLEEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJZ9</accession>
    <name>R0IJZ9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">acylphosphatase</fullName>
            <ecNumber evidence="2 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_91849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027637.1">
        <property type="nucleotide sequence ID" value="XM_008029446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJZ9"/>
    <dbReference type="STRING" id="671987.R0IJZ9"/>
    <dbReference type="GeneID" id="19405936"/>
    <dbReference type="eggNOG" id="KOG3360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_4_0_1"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acylphosphatase"/>
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    </dbReference>
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        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
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        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
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        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
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        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
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        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
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        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA85176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="89" mass="9604" checksum="4A4F9E5A13DCC034" modified="2013-06-26" version="1" fragment="single">QIRYTVHGQVQGVNFRSFTQKQARSLGVTGFVTNASDGTVQGEAQGTEHRISDFVHYLNKGPPASSVSSVDASDMPTESGESGFHVRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IK56</accession>
    <name>R0IK56_EXST2</name>
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        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_117946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029498.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QV54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
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        <property type="entry name" value="QRT3-like"/>
    </dbReference>
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        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342411" evidence="1">
        <location>
            <begin position="25"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="415"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="779" mass="83414" checksum="C7A91AD354C34269" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0IKG0</accession>
    <name>R0IKG0_EXST2</name>
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        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_137979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027775.1">
        <property type="nucleotide sequence ID" value="XM_008029584.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0IKG0"/>
    <dbReference type="GeneID" id="19396438"/>
    <dbReference type="eggNOG" id="KOG0350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_15_2_1"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="198"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="535"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA85366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="715" mass="78616" checksum="EE48B18BC5F2779C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>R0IKM0</accession>
    <name>R0IKM0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_154973</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008029626.1"/>
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    <dbReference type="SMR" id="R0IKM0"/>
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    <dbReference type="HOGENOM" id="CLU_000022_6_2_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_3"/>
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    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
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        <property type="entry name" value="ACP-like_sf"/>
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    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
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        <property type="entry name" value="HTH_51"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
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        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
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        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
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        <property type="entry name" value="PKS_mFAS_DH"/>
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        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
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    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
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    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
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        <property type="entry name" value="FATTY ACID SYNTHASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
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    </dbReference>
    <dbReference type="Pfam" id="PF00550">
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    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
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    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
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    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="376"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1282"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1644"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1745"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1857"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1282"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1429"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1593"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1613"/>
            <end position="1628"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
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    <dbReference type="PANTHER" id="PTHR40626:SF30">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="802"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA87900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="951" mass="104681" checksum="E141F5D39879F281" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>R0ITN3</accession>
    <name>R0ITN3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_168786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908559">
        <property type="protein sequence ID" value="EOA88001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024496.1">
        <property type="nucleotide sequence ID" value="XM_008026305.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0ITN3"/>
    <dbReference type="GeneID" id="19400671"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001073">
        <property type="term" value="F:transcription antitermination factor activity, DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="1217"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA88001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1410" mass="161512" checksum="227FF318C9D6455E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0IUY8</accession>
    <name>R0IUY8_EXST2</name>
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        <submittedName>
            <fullName evidence="10">Carbohydrate-binding module family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_46800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA88590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025588.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="407275at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF15">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
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    </dbReference>
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        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA88590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="545" mass="58063" checksum="BE92A038DC71DC37" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0IWD8</accession>
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            <fullName evidence="1">DHHA1 domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008025104.1"/>
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    <dbReference type="AlphaFoldDB" id="R0IWD8"/>
    <dbReference type="STRING" id="671987.R0IWD8"/>
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    <dbReference type="eggNOG" id="KOG0188">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="130" mass="13916" checksum="6401D81BC7E9C24C" modified="2013-06-26" version="1" fragment="single">RVLDEVTKFFEDDSNKFMVKKLDWSSNVNKAISEAIKTVSGPKSALKDRSLYLFSASPEEGKVVHGCYVSEPFKNAGADGPKWASAVTPIIGGKAGGKPGAPTAIGQGTNADKVDEGVEEARKWIEAFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXG6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_159676</name>
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    <organism evidence="2 3">
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        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Han J."/>
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        <location>
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        </location>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="282" mass="30357" checksum="794B1BE54A66FAF6" modified="2013-06-26" version="1">MLFFIALSLFHLSVALPSLQPRSSGYLVILDTGVGHRSTPIPRWPTSLRRIGTDGTNAANLTTFGTDSVAHPFDEPIEGFALAYSPSTSTLFSATGRGIIRTNLDGSNDQVIVTDSSSGSSTSSIVSITVAEKAQKIYYGNQYTGLIYSANYDGSDATVFRNVSQGLNFLFPSYAPANTYPGDIVVDEERGWLYWSSSTDGSIRRIQLSGSGAEQILATAADKPGQLRIAATSLFWAERGSWSSSPTAIKYLDRMLDQLPSSPCCTGSAYVAWECLQVFAPE</sequence>
</entry>
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    <accession>R0IZV0</accession>
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            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA90265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0IZV0"/>
    <dbReference type="GeneID" id="19401941"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
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    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="BBE"/>
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    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
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    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
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    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343738" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="658"/>
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    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="191"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA90265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="658" mass="71658" checksum="3D5763C16DC88D21" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZW0</accession>
    <name>R0IZW0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutaminase A</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="5 6">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <location>
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            <end position="135"/>
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    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0J276</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="57684" checksum="042CA8A8750A655B" modified="2013-06-26" version="1">MDSDTLDPKTIELVLPSFALLRHIPVSVLFAAFVVAVSVYLPRFRYKSQLEKFPLILEHLSGEQRRAKFLAGAKALYKDGHEKFRGVAYRMQTLDEMQIVLPISMLSELRKAPEDVLSFYDMFSKVVDTIKRDLTPKLTKITSNICNEVDAALDTYLPSHNEWTEINVSKTALDIIAKVSAHLFIGDSVANEPGYLDCTQNFTVHLGEATKAIKETRVWLRPFLAPRLPAVKRLLETRRNLRNYVKRVIEEREAKSKDPDWVPPEDMMQWLLNRTDRQKDTLEDCTAAQILLILGTINASMQTLIAILHTLAVTPEYVEPLREEIRNTLNSDGSIPVSSMKEFSKMDSYFKEVGMHFPVIIEPYFRRVRKGYTLSNGQYLPAGVPIVIINPLITDSKYDAFDGFRHYNLRESSAQKDKPQHRWLIANETEFRWGYDNHVCPGRFYAHNLLKIILARLIEKYDIKMPGGVTGLEARYKMVEHGNVVMEPRDKPLMIRRVKSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2V3</accession>
    <name>R0J2V3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_152434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020582.1">
        <property type="nucleotide sequence ID" value="XM_008022391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2V3"/>
    <dbReference type="STRING" id="671987.R0J2V3"/>
    <dbReference type="GeneID" id="19397185"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132739_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="165" mass="18525" checksum="1618B5783C341740" modified="2013-06-26" version="1">MASNSTETETQTGPRSSTLIVAIVVPSVLIVLLLLLILVGLVLPRLVREEVLAKEKRWKTRQEELDGHIQSQNFGDWLASQKERGGAGQQTTEALCAICLEEFVEDAQVRGLRCSHAFHTRCLDEWFTKYNEYCPLCHGAIIPGPRRLARTQERVESTIPVMLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0J494</accession>
    <name>R0J494_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_86727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020480.1">
        <property type="nucleotide sequence ID" value="XM_008022289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J494"/>
    <dbReference type="GeneID" id="19405602"/>
    <dbReference type="eggNOG" id="ENOG502SMPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062059_0_0_1"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353359" evidence="2">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="321" mass="36756" checksum="8A53784DA0E55265" modified="2013-06-26" version="1">MHQLTTSFFAAVLLIATNVAAEVKPYISTEAEYNTECKTCPRSLCPNQIAYDYYDTFNVTCWTHGTKIMGDDLWLKTEAGCYVTQYDVVEYPGDYTTDLKYCGAASEVQKLTIQKAQLKYKTECRICPELTCDTISYLKEKTNLELTCWYPDGQVIIDDPYWLKTSNNCYVAQKNLYSKPDLAKLDNCGPIPFLEDLWHNNENGTSDNNKRSPSAAPLPEPLPKKEADMSVMYLINVTVGEEYAYCRSCTQDTCAVQRTYEFNDEVWLQCITQKNATGWWSQTTDFCYIKNTDFWQSPEGDYYRMPTCERFDGDPSGGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0J564</accession>
    <name>R0J564_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_162438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </comment>
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        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
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            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
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        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
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    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
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        <property type="entry name" value="Prenyltrans"/>
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    </dbReference>
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    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="102"/>
            <end position="462"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="480" mass="52826" checksum="11FCAF61D76CDEA4" modified="2013-06-26" version="1">MALPLRFSAQAPSARLEEIVPESDRIEELSDEALDSEYEDMGTATAEEQANIAYLESIRIPIKDSLVTDSSRVEEETSAVILPYLEGNPNDWPLNAFGIPKLQRDRHEAMLKKIIEDYPPQAATVDAARPWIVYWATQSMTALGLDISTYQKRVAHTFSLAQHPEGGFGGGYGQYAHLACTYAATLSLAIAGGDAAYDTINRKTLWHFLGRMKQADGGFTMCAGGEKDIRGAFCAMVILSLTNLPMELPPDAPARNHGLTTFTDKLGDWVSRCQSWDGGISAAPGNEAHGAYAFCGLGCLAILGPPKQTLHKYLDVDLLTAWLSSRQCSPECGYNGRTNKLVDGCYSHWVGGCWPIVEAATTTGLWNRAALGRYILAACQEKKGGLKDKPGKHSDAYHTCYNLAGLSTAQHHYLYDESVNKSLGTGNLGAPYHWKMQARYDAADKVWEDADVVKPVHPVFVIPFMSVYEMRKHFEDKEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0J596</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_40929</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022107.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19404656"/>
    <dbReference type="eggNOG" id="ENOG502SN78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320540_0_0_1"/>
    <dbReference type="OrthoDB" id="4207369at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="201"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="411"/>
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        </location>
    </feature>
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            <begin position="618"/>
            <end position="830"/>
        </location>
    </feature>
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            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
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            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
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            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
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    </feature>
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            <end position="478"/>
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            <end position="507"/>
        </location>
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            <begin position="676"/>
            <end position="686"/>
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            <end position="723"/>
        </location>
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        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA92070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="830" mass="89999" checksum="D77550D471EA4EF2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0JHD5</accession>
    <name>R0JHD5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_181974</name>
    </gene>
    <organism evidence="4 5">
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031419.1">
        <property type="nucleotide sequence ID" value="XM_008033228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JHD5"/>
    <dbReference type="STRING" id="671987.R0JHD5"/>
    <dbReference type="GeneID" id="19401881"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="279"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA80803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="429" mass="48223" checksum="C3BCAF4508D7C853" modified="2013-06-26" version="1">MWLAYLETTEAIYLPTPMPHGAPPRPGLIVQRFPGGLTWSPAIGVRGFMHTHAARCTPVTSKKNNMATTTTATTEAETWVHYHDGGVPGRRRVLKGTAAKPTFTALPKIDFQRIYSDSLADRKELAAQVGAACRDIGFFYAVNHGVDDEMLQDTMDALKRYFALPTHVKMETHNQKTDKFRGYEAFLEGKLDPSTRGDVKEGFLMGEDFTDPEQLSLLTSTPNPPTHTPRNQWPTHPSALFWRPALYRYYRAMFAFSKRMLRVFALALDLPEDAFDAITTHPMTNVRAVHYPPQQCESDVGIGAHTDFCWFTLVCQSPTAYPALEVLNGNGEWIPVLPEPHTFVVNIADFLKLVTGGTWQSTVHRVRNMGGEERYSIPFFFSPNEDASVSVVRHLRSDGVAYAEFGVGEYFQKRLDIDRRTHLEGHAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JKG3</accession>
    <name>R0JKG3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_96855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030189.1">
        <property type="nucleotide sequence ID" value="XM_008031998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JKG3"/>
    <dbReference type="STRING" id="671987.R0JKG3"/>
    <dbReference type="GeneID" id="19406267"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="261" mass="27386" checksum="809890520FA955EC" modified="2013-06-26" version="1">MYDHFKVTGKKVIVSGGARGIGGTVARHLVAGGAHVAVFDILDEPGQAHVAKLNEQGPGKALYFHVDTSKREEVFAAVAKAVDALGGLDSLHNIAGIDLPVPIADITEADVDLTFNVNFKGSLWLAQAAVPFLQASGGGTILNTGSDSALFPFPDSSHYSASKGAIHSLNRSKSTAWAKYNIRVNAVIPAAKTDMYYEAMALKTPEERAATLAWQKASIPLGGELGQADDVAPTWVFLTSDAAKFITGQLISVNGGLSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JMD7</accession>
    <name>R0JMD7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_156189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029560.1">
        <property type="nucleotide sequence ID" value="XM_008031369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JMD7"/>
    <dbReference type="STRING" id="671987.R0JMD7"/>
    <dbReference type="GeneID" id="19397601"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF222">
        <property type="entry name" value="MALTASE MALT (AFU_ORTHOLOGUE AFUA_8G07070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="22"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA82408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="587" mass="67945" checksum="09273F4B33A31F82" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNE6</accession>
    <name>R0JNE6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_96792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029757.1">
        <property type="nucleotide sequence ID" value="XM_008031566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNE6"/>
    <dbReference type="STRING" id="671987.R0JNE6"/>
    <dbReference type="GeneID" id="19406265"/>
    <dbReference type="eggNOG" id="KOG1726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048918_0_0_1"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="343" mass="38807" checksum="B0B22BAF83A4DF08" modified="2013-06-26" version="1">MFGFIADGLTVVTTVFFPIFASYKALHTSDPALLAPWLIYFVVLSACTAVENTFDFILSWVPFYSWIRFFAHLYLILPGAQGASYIYQEHLEPFLYQHEREIDDFISQSHDRAKAAGMAYIEMGIEWVRVNLLGFAPRKPEAPRPAGQTYAQNLMSRFQMPAARGSNDLYGLVNQALSGASALYTAGTADTKNAQAADLSRGAAKLVPDSIRNDEDRLNYVTSQRQRLESLLQAFDREQENIRTQQKGGNTPHETSRNSPISLSRNRSEAEFDRIERDELSSGSDRPPYPITPPGMDRRTSSGWMPWNWQRPAHPEDDPLAYGREPGQLRNRSWGTEFDLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNM8</accession>
    <name>R0JNM8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_121314</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029824.1">
        <property type="nucleotide sequence ID" value="XM_008031633.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0JNM8"/>
    <dbReference type="GeneID" id="19395844"/>
    <dbReference type="eggNOG" id="KOG0970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001718_1_0_1"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029152.1">
        <property type="nucleotide sequence ID" value="XM_008030961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQI8"/>
    <dbReference type="STRING" id="671987.R0JQI8"/>
    <dbReference type="GeneID" id="19396531"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038177_0_0_1"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="240"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA83438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="386" mass="44576" checksum="8D1E85CE35E96E12" modified="2013-06-26" version="1">MWRDRTNLFISYRQSYSHHPQKKTRYGAPASNGFGDARRMSEERQGLMASAAFEDDGDAVIEMDLLPPRWLDVQDEITEYLAEIAKQTRKLDQLHQKHVLPGFDDEDVKKREEREIEQITQAITRLFQKCQQAIKRIEMMVREAKQQGNIHQGEEVMAQNLKISLASRVGEVSSMFRKKQAAYLKKLRDLGGFASPFRSATPVQNPYNDPALQESDADRSFSQSTLLQTKQQRMRHDPNEALIAQREREIEDIAQGIIELANIFQELQTMVIDQGSMLDRIDYNVENMTRDVKEADKELKVASGYQRRTVKRKIMLLLAILIAGVFILLSLKLSRKGGNNIPKVPDVPPAAAIRTRRQSTTMQKNHVWHRRKRRLWKGPIDDPLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JQQ1</accession>
    <name>R0JQQ1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_140085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029192.1">
        <property type="nucleotide sequence ID" value="XM_008031001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQQ1"/>
    <dbReference type="STRING" id="671987.R0JQQ1"/>
    <dbReference type="GeneID" id="19396537"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_1_1"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA83488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="217" mass="23873" checksum="5BAC709AB0E9217F" modified="2013-06-26" version="1">MELSENKQRMARGELYHAFTPELVAERARCKHACARYNQAGDVPRRKLTELFRDVIQDKTPLPPQAQTAEEDDKLFENDPWIEPPLAMDYGYNVRLGQNVFINFNSVFLDTCLITIGSRTLVGPNVSFYSGTHPLDPAVRNGTQGPELGKEIHVGEDCWIGGNVCILSGVVIGKGSVIGAGSVVTKNVPDFTVVAGNPAKFIRKIETSMDAPRDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0JV18</accession>
    <name>R0JV18_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_181593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="370" mass="39738" checksum="A789375B405FC9D3" modified="2013-06-26" version="1">MPPPPDDWKKEEWDLPLWITEDAIVPTIVTTVIPDPLPPLPQVTVPIDTASMASPTQPPSDSTRTRYRPSTRPDGYPSTLPWPPYSLGAPTPATDSWETSVSTTAVFLQTPYPETQNTAPASTADGFTATGTRAASPSPVIPHKGRPSDWGWANKGTNHAPIYAIATVVPIVLLAIIAAVALVCLRRRKRRKAAEAAAQAATQEMKKDMDEVTVQAHIAQPPSPPLSPPPPAVSVSRHYTAPPDHLPPTSTPSQFQPIILGPINPSSNGAYLTGIDTSDMVPINSGPQTLVDPFADNHSLSEPPPPYRPSSVAPPSFTTNSRPSSVRVPVSPVCPHGAERSPFDDPDDGVSILSELSFQRERFTGRQSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYH7</accession>
    <name>R0JYH7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_142666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030797.1">
        <property type="nucleotide sequence ID" value="XM_008032606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYH7"/>
    <dbReference type="STRING" id="671987.R0JYH7"/>
    <dbReference type="GeneID" id="19396680"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="297" mass="32313" checksum="2EAD96B7A8942F3F" modified="2013-06-26" version="1">MAPNWDRLIRFIATDGRELRGQPILPSPDFDVGTTTEQTGLKAKVIDVKNNDIFDPATKVTDEEVTVKKLLGPVTQDEVPIIRCIGLNFIKHIQEGGRTLPPYPSTFIKASTCLTDHGAPIVIPKIAQDNQADYEGELCFIISRDAKDVSEADAYSYIGGYLSGNDVSSRKLQRDPLLAGTVPQWNFSKGFDTYAPLGPQIVSTSVIPDPSKLHLKTIVNGQLRQDSGIDDLCFKIPTLVAYCSQGTTLKKGTVFMTGTCAGVGYAMKEPQFLKPGDVVEVNVSPHVGTLKNVVEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYL4</accession>
    <name>R0JYL4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_28927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026392.1">
        <property type="nucleotide sequence ID" value="XM_008028201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYL4"/>
    <dbReference type="STRING" id="671987.R0JYL4"/>
    <dbReference type="GeneID" id="19403294"/>
    <dbReference type="HOGENOM" id="CLU_1687783_0_0_1"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="156" mass="17331" checksum="A69CC50B85490A3B" modified="2013-06-26" version="1">MYDYSDARDLTLFVNGSPYAYRNFGKLAKHVVIVLACHRSTMDQIPTDFRAWADNCAVFIEALNIWADDLFGTSVSGFTSQIVTLNHPHLVRRLILAGTAPTIGLGVVAYEPKIVEALRLVDSAVTLEEVGNVFVRIALSLSNEKHTLGRAWLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZL3</accession>
    <name>R0JZL3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 11 RING-H2 finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_143299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031035.1">
        <property type="nucleotide sequence ID" value="XM_008032844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZL3"/>
    <dbReference type="STRING" id="671987.R0JZL3"/>
    <dbReference type="GeneID" id="19396710"/>
    <dbReference type="eggNOG" id="ENOG502SFYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_956417_0_0_1"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342977" description="Anaphase-promoting complex subunit 11 RING-H2 finger domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 11 RING-H2 finger" evidence="3">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="331" mass="36573" checksum="47A1DFC48E2F93B8" modified="2013-06-26" version="1">MQPFFPHGRLLLVRPVCALLTAIQHCIFSWLKQESSLEKCPMCRQRKPEPPPIPRATPSPRSKPLDLPEYPPGDEPNEQQEPYDAPEEEDDIPYPEPSAEQPLLPPPNFRPFFALIEDTTSGEHYHPYVHYVFADDDPTIVTAASMRGLGLDDTKYLPQDAPAGGERRQNQGGEEGEEEDDQDLPVESPFPPPIPGVKEHYLIVDVGADGRTIVDAQSLSPEWQITDTGVRTAPSFDEDSPDPGYMLRIEGVEIPRKNKGKGKGEAGVDKLNEAREQQGDIFGALEGLVQNIERGLGIAGQISGVDRRESKAGIPADVCEEDAEKMADHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZP5</accession>
    <name>R0JZP5_EXST2</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_169146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025986.1">
        <property type="nucleotide sequence ID" value="XM_008027795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZP5"/>
    <dbReference type="GeneID" id="19400803"/>
    <dbReference type="eggNOG" id="ENOG502SRF9">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tmemb_14"/>
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    </dbReference>
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        <location>
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            <end position="47"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="76"/>
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            <end position="102"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA86368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="106" mass="10656" checksum="9C6550E1F644247D" modified="2013-06-26" version="1">MSSIGNIALVLGALTAGGGITGYVRTGSVPSIAAGCTVGLLYILGGYRVNSRAAYGVELALLASVILAGSSIPRAIKSGKPLPIGLSILATFGLWTFGNAFMNKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZR9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_99534</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031068.1">
        <property type="nucleotide sequence ID" value="XM_008032877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZR9"/>
    <dbReference type="STRING" id="671987.R0JZR9"/>
    <dbReference type="GeneID" id="19406441"/>
    <dbReference type="eggNOG" id="ENOG502SKG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA81672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="333" mass="36871" checksum="294815392475A7C9" modified="2013-06-26" version="1">MAGLWETFAYAFRALGSKDQQSAGIALVAQILVLVAPIWVNAFAYMVFARIVHFYSPTRKVWVLSPSILALIFVSLDILSFVIQLVGGGMAGPGASPESQKKGLNIYMGGIGMQEGFIILFLGLVIKFHRDQLQAERAGRLNADKAGGWKWLIWALYACLLAITIRIVYRLAEFSGGLGASNPLPSNEPVLYVLESTPMWLAILVWNIVHPGRFIQGPDAKMPRSWLSRHLCCCCHRRRCDDCHGKLGHAGPHHHSLSGNSEVEENREMNPVSKKQRGRVSVTAANPFLDAQSRDSSPTGDAREQLRLRPPPAADNHREVSPEPHAYTAYRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1F9</accession>
    <name>R0K1F9_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_23501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028648.1">
        <property type="nucleotide sequence ID" value="XM_008030457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K415"/>
    <dbReference type="STRING" id="671987.R0K415"/>
    <dbReference type="GeneID" id="19396499"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343805" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA84314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="599" mass="65042" checksum="9D065FBC896286B8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0K432</accession>
    <name>R0K432_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_29495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908562">
        <property type="protein sequence ID" value="EOA87853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024517.1">
        <property type="nucleotide sequence ID" value="XM_008026326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K432"/>
    <dbReference type="STRING" id="671987.R0K432"/>
    <dbReference type="GeneID" id="19403344"/>
    <dbReference type="HOGENOM" id="CLU_112101_1_0_1"/>
    <dbReference type="OrthoDB" id="3692536at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="150" mass="16459" checksum="B2F2606B4F8EE11D" modified="2013-06-26" version="1">MANRGMWANGQAAAPVIVGRVNLNNYQVWYIFDVRVAEEIRQVFAAAPPKLRWVFDMFCRLRGLSPYNATFGSGLSGYSPVVARTTLYARQILGGRPSYLKAFLVHSRGACNATFCDNCAPVLDRAKEFTAFAGCVSIYGEWGGACSNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0K579</accession>
    <name>R0K579_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_168598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024243.1">
        <property type="nucleotide sequence ID" value="XM_008026052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K579"/>
    <dbReference type="STRING" id="671987.R0K579"/>
    <dbReference type="GeneID" id="19400602"/>
    <dbReference type="eggNOG" id="ENOG502S7R4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_1_2_1"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="908"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1385"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1429"/>
            <end position="1439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA83652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1439" mass="159380" checksum="30248F7090A69B6E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0K620</accession>
    <name>R0K620_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_171955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027463.1">
        <property type="nucleotide sequence ID" value="XM_008029272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K620"/>
    <dbReference type="GeneID" id="19401147"/>
    <dbReference type="eggNOG" id="ENOG502QTH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_1_1"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="219" mass="24869" checksum="5AEA38B6BB98B4D8" modified="2013-06-26" version="1">MTNFQINVVIDTVCPWCYVGKKRLEKGIAAYKEKYPDSNDTFSTSWFPFYLNPDAPKSADKQQLYESKFGKERTAMMQVRMSELGKAEGINFKYGGKTGNTRDSHRLLQLGKTKGPLVQTRIIEELFAAYFENEKDITSRDVLTEAGVRAGLDKKEVKEWLKSDQGGPEVDREVVQARQQHITGVPNFTINDKYEIGGAQEPAAFVQIFERLKKQEGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6A2</accession>
    <name>R0K6A2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_172009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027532.1">
        <property type="nucleotide sequence ID" value="XM_008029341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6A2"/>
    <dbReference type="STRING" id="671987.R0K6A2"/>
    <dbReference type="GeneID" id="19401151"/>
    <dbReference type="eggNOG" id="KOG2438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_4_1_1"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="9">
        <location>
            <begin position="443"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA85044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="613" mass="68176" checksum="B26C63D6983E70C7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6W8</accession>
    <name>R0K6W8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SETTUDRAFT_90389</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027720.1">
        <property type="nucleotide sequence ID" value="XM_008029529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6W8"/>
    <dbReference type="STRING" id="671987.R0K6W8"/>
    <dbReference type="GeneID" id="19405834"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033620">
        <property type="term" value="C:Mei2 nuclear dot complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="18">
        <location>
            <begin position="12"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="17">
        <location>
            <begin position="214"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="16">
        <location>
            <begin position="361"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EOA85289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="571" mass="64549" checksum="FDA817F3868CCEEF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8W1</accession>
    <name>R0K8W1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_169474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026469.1">
        <property type="nucleotide sequence ID" value="XM_008028278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8W1"/>
    <dbReference type="GeneID" id="19400919"/>
    <dbReference type="HOGENOM" id="CLU_046000_0_0_1"/>
    <dbReference type="OrthoDB" id="3737134at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="448" mass="51087" checksum="E3186E8625E29722" modified="2013-06-26" version="1">MAKQTLVLQNCPAFVYAAHNPSAIWRCTLKLVNCKEEFGLFLKFSQQNPDADGEQFVIFQYEGDNFVPGHNSLTETDIVVSAKELIDIQARNGTSRPRTMSLTLKEACTVWCPKEPSYVHIRFEDLLELARATDVRIFFDTRRLGNKFTDFQKIFEGSQQFKTMPVKDEFTKSHQKENWMMLNLKFGVAPAAYVPIEDTETRALPSIEYAGARASVVKDDPPSYDEHVPRKRPRCDRSLSPGFVWKCPRYSACSPSPTEVATPASLLSSTSTVQTDHFQNAITSGVREALPTVLKERKFQKMLAYSIVLSSLQPEPDSNQIPTTRTRHRRTPTSQSKFEALIQNIVDQQTSESLKSALFQLEEMGDDLKIELNVLQEEIMARLNDLINPVLDEFKDDLNIGFEEIKARYQVLHLKTLDTFDIIGNQKLCRRRCPRVPERGRRAKSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0K989</accession>
    <name>R0K989_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOPA 4,5-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_163660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027375.1">
        <property type="nucleotide sequence ID" value="XM_008029184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K989"/>
    <dbReference type="GeneID" id="19398841"/>
    <dbReference type="eggNOG" id="ENOG502S93P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090062_0_1_1"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19694" checksum="04AE8A94D03F97BE" modified="2013-06-26" version="1">MADPRKYTYDSPLKGYENCEPLPNEKAADGKSYVNPPTGRLSDAYKSFVSPITNGIRGGFDIHIYFLQTDEEETKFANELWERIRREFPELRIYRVWDRPIGPHPLAMFEVNLFTPEQFGAFIPWLVINRGPLSALVHPNTGDEERDHTQRATWMGQPLPIYWNKLNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9E6</accession>
    <name>R0K9E6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_169421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026330.1">
        <property type="nucleotide sequence ID" value="XM_008028139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9E6"/>
    <dbReference type="STRING" id="671987.R0K9E6"/>
    <dbReference type="GeneID" id="19400900"/>
    <dbReference type="eggNOG" id="KOG1405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA86054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="425" mass="47138" checksum="5E66AD2FCDC883A6" modified="2013-06-26" version="1">MMADYSRSYGNYIADLDGNVLLDVYAQIASIPVGYNNPSLLLAASSPEMASAIINRPALGNFPQHDWADILESGILSVAPKGLNQVFTAQAGSDANELAYKAAFMWKRQQQRGGADADFSAEDIASSMINQSPGAPNMSIMSFKTGFHGRLFGSLSTTRSKPIHKLDIPAFDWPQAPFPTLKYPLAEHEAENRQEEQRCLDETERLIKEYHNPPVAVVVEPVQSEGGDNHATPFFFRGLRAITKKHDVLLIVDEVQTGVGATGKFWAHEHWGLDTPPDMVTFSKKAQTAGYYFGNDALRPNKPYRQFNTWMGDPARALLFRAIIHEIQRMDLVTNTAATGDYLFAGLQRLAAQYPREIQNLRGQGQGTFIAFDSARRDEVLKKAKGQGVNIGGSGESAVRLRPMLIFQKHHADLLLERLEKVFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9H5</accession>
    <name>R0K9H5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_110755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026349.1">
        <property type="nucleotide sequence ID" value="XM_008028158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9H5"/>
    <dbReference type="STRING" id="671987.R0K9H5"/>
    <dbReference type="GeneID" id="19395442"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="115"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA86074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="331" mass="36895" checksum="BE4036755D8995BC" modified="2013-06-26" version="1">MTHDGVCILILSLKHGAPYPQDLQYVQTVRRNLIPQLSWPTIKKNLEYFSTRFPTRFCKSKSGAKAAQWLLTQVQDVVARANHASQTTTTTTAAAAAVVVSVAPFKHSKFGQKSIVARIQGRSNTTVIVGAHLDSINVKKRKTGRAPGVDDNGSGTFLLLECLRVLLTDAHHHGYGLEKTIEFHWYAAEEVGLRGSRDVFRRYRREGRRVWGVLQQDMVGYTRGTLDAGKEESFGLMTDFTHAGLNAFVAQVIHEYTDISYVNSTCGYACSDHVSATRNGFPASFVLESAPEYQNPYIHTPRDTMEHIDPAHVLQHGRLVLGFLYELGFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9K8</accession>
    <name>R0K9K8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_163736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027457.1">
        <property type="nucleotide sequence ID" value="XM_008029266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9K8"/>
    <dbReference type="STRING" id="671987.R0K9K8"/>
    <dbReference type="GeneID" id="19398869"/>
    <dbReference type="HOGENOM" id="CLU_1759926_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="148" mass="16609" checksum="3333AD4DD978AF2F" modified="2013-06-26" version="1">MVQEGGSEAAQDSEQESAEAEDRGSVEVEKQASAMPATPSLEQNGVSDKLVAPGVDQMLWGDKYDLIFKLQDRRDDYEEDIDWEDVRKDQGYPWSRQTLESALHGLIQLLRDNGREVDSDDFPGTVDDVMDFISEEHGDELEDHYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAG7</accession>
    <name>R0KAG7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_104657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022841.1">
        <property type="nucleotide sequence ID" value="XM_008024650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAG7"/>
    <dbReference type="STRING" id="671987.R0KAG7"/>
    <dbReference type="GeneID" id="19395058"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
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        <location>
            <position position="503"/>
        </location>
        <ligand>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA89968.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="R0KAH5"/>
    <dbReference type="SMR" id="R0KAH5"/>
    <dbReference type="STRING" id="671987.R0KAH5"/>
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    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_2_1"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
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        <location>
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            <end position="145"/>
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    </feature>
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        <location>
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            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="61"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="123"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA85222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAS2</accession>
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        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
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            <taxon>Pleosporaceae</taxon>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="327"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="481" mass="52312" checksum="87E9C6E3594117EC" modified="2013-06-26" version="1">MLFEQTNRQFAWTANKDSTAQGVQAADSMIIGPNYFTALDRFPKDTPVTVGLNMAYMESDWQTRITTMAQAAVNGMKNVKLYSFEVGNEPDLWLQNSFRSGTWSGKTYTDQWLDRCEAIYNNVLRNASLPSSFFEAPCTASTIGTTFEIAQLVDDGIMTGRNGDNFLSTWNQHDYYYFIGVTPTPITLDELMDLDTTNTQFKYWEKQVGIALKTGLPYVLREMSSIGPIGMPGVSDAFGSALWTMNFFLYAASIGISSVEMHMTDNSNASAWQPIPMYGHDTTFVRPQYYAHAAVAQIIGNGNGTTQIYAENTGNVGNGYHGRIRVYSAYANDKLQSVTMINSKQANASTSDKGTFTFNLNLGSDNANKDVYISYLTADGAESQTGVTWNGMSYDDVTGASSTVDSTVTMTTTDGSGKLSVPVRDTQAVVANIGSQLGVNAVLKPDGTQSKKSNAASRSLDNANIAIFSGLAAMLISLMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDJ5</accession>
    <name>R0KDJ5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_166841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021658.1">
        <property type="nucleotide sequence ID" value="XM_008023467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDJ5"/>
    <dbReference type="STRING" id="671987.R0KDJ5"/>
    <dbReference type="GeneID" id="19399948"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA90973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="484" mass="52448" checksum="1FC97F83D67C4C8E" modified="2013-06-26" version="1">MASRIASKRFCAALRAPRTSYTPARFASAASGVKGSSLPQDVLDSIARDSTLPTPDPPASSKTAGLVNQQLPYMVPTYVRPPPMFEKGDGCYMWDIENRRYLDFTSGIAVNALGHCDAGVAQVIAEQAKQLIHTSNLYHNPHTGLLSKQLIQLTHATGGFASATRTFICNSGSEANEAAIKFARKVGKSLSPDKDKHEFVSFHNSFHGRTMGSLSATPNPKYQKPFSPMVPGFRYGTFNDVAAINELVTEATCGVIIEPIQGEGGVNVATPEFLVALRKRCTEVRAVLIFDEIQCGLGRTGTFWAHGGYPKECHPDILTTAKALGNGFPIGATIVNDFVCDHIKTGDHGTTFGGNPLGSRVASYILSRLSSPEILDSIPAKEQAFRKHFDALRDRFPDHIKEVRGKGLILGLQLDADPTPIVTAARERGLLIITCGTNTLRFVPPLVITEAEIEEGMQILKQAMESVWVEGDSVKPTPGQQEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KE79</accession>
    <name>R0KE79_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3632 domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_182541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021772.1">
        <property type="nucleotide sequence ID" value="XM_008023581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KE79"/>
    <dbReference type="STRING" id="671987.R0KE79"/>
    <dbReference type="GeneID" id="19401924"/>
    <dbReference type="eggNOG" id="ENOG502S7Q5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035263_2_0_1"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34299" checksum="9D53FE2B3CF4B093" modified="2013-06-26" version="1">MPRTAQQNEKILEALASADDGGQQIDAIARIRGWFRPKDASTSYVIVQEYLDEKIDMGEVVSSLFGPIDEKINAARLDDVDFMDLWYSIIHSARRVPYHENSGDCNHNKLVDLIKNSKEHSVPNNEIYNYIYSEMTDFGLACREAYNDVPVAHNGFIDKEVEAWANLNALYALVTKNGVYDLSIYAIYALRPALEEPPVDDPFSTATQKYDANIPAAAAWVFAYGHELCRLDKDLTPSDSKMGNPGKGGELWTGRAGFSRERWALWKERFTAVGKMDGVKETTRVMARDAVEAMERSETSEHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0KED6</accession>
    <name>R0KED6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SETTUDRAFT_168826</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024577.1">
        <property type="nucleotide sequence ID" value="XM_008026386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KED6"/>
    <dbReference type="STRING" id="671987.R0KED6"/>
    <dbReference type="GeneID" id="19400680"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_0_0_1"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="971"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="423"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EOA87674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1157" mass="127496" checksum="242ED0E7420C24F6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEN9</accession>
    <name>R0KEN9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_162080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020596.1">
        <property type="nucleotide sequence ID" value="XM_008022405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEN9"/>
    <dbReference type="STRING" id="671987.R0KEN9"/>
    <dbReference type="GeneID" id="19398272"/>
    <dbReference type="eggNOG" id="ENOG502SBP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180978_0_0_1"/>
    <dbReference type="OrthoDB" id="5371169at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="79" mass="8284" checksum="13AD02937BBDC6B6" modified="2013-06-26" version="1">MSSPLLDVWDAAAAQPFHPAVGKDTQFTVGFVLLAISLVLTTIFGLNRSLINLPLLGVPASLAFGFGSVYMICAVGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGZ1</accession>
    <name>R0KGZ1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SETTUDRAFT_176594</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023925.1">
        <property type="nucleotide sequence ID" value="XM_008025734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGZ1"/>
    <dbReference type="STRING" id="671987.R0KGZ1"/>
    <dbReference type="GeneID" id="19401481"/>
    <dbReference type="eggNOG" id="KOG0215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000015">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022648.1">
        <property type="nucleotide sequence ID" value="XM_008024457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKP2"/>
    <dbReference type="STRING" id="671987.R0KKP2"/>
    <dbReference type="GeneID" id="19400203"/>
    <dbReference type="eggNOG" id="KOG0190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005145271" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="323"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="464"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA89689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="524" mass="57111" checksum="5EE7E19C8B35E8AC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLQ8</accession>
    <name>R0KLQ8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_167017</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021986.1">
        <property type="nucleotide sequence ID" value="XM_008023795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLQ8"/>
    <dbReference type="STRING" id="671987.R0KLQ8"/>
    <dbReference type="GeneID" id="19400012"/>
    <dbReference type="eggNOG" id="KOG2900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_1_2_1"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="PROSITE" id="PS51918"/>
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        <source>
            <dbReference type="EMBL" id="EOA90049.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNU9</accession>
    <name>R0KNU9_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_144794</name>
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    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90744.1"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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        <property type="entry name" value="RmlC_Cupin_sf"/>
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    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
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    </dbReference>
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    </dbReference>
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            <end position="695"/>
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        </location>
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            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="729" mass="79144" checksum="F683A55CA1C0D52D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0KP82</accession>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="6" type="ORF">SETTUDRAFT_37319</name>
    </gene>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EOA89652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008024269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KP82"/>
    <dbReference type="STRING" id="671987.R0KP82"/>
    <dbReference type="GeneID" id="19404243"/>
    <dbReference type="eggNOG" id="ENOG502S4G7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134926_0_0_1"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA89652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="152" mass="16429" checksum="2D7612169D655AC1" modified="2013-06-26" version="1">MTSKVGLSVPMPLLAPATATWAAPFAAYYIFLQLRVVRKRFSTKTRLGDKVADSKENIDPLLVASRAQVNFAENVPLALGIALLAEINGGNRFYINYALGALFAFRIIHAEFGMYVKGGAGIGRPIGFLGTQTVVAGLAGYAAYLIKDYWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQ54</accession>
    <name>R0KQ54_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_36611</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021325.1">
        <property type="nucleotide sequence ID" value="XM_008023134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQ54"/>
    <dbReference type="STRING" id="671987.R0KQ54"/>
    <dbReference type="GeneID" id="19404159"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031986_0_0_1"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="126"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA91129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="428" mass="45880" checksum="46C29D3796BDA2AD" modified="2013-06-26" version="1">MHPGSDPMGVPPSFAARRPHAQQLGSFELPPPPMHKYPFNSTVTASQSPQAPATIASVGNLLTPPNTNHSDVISSSGVSTAGPQYSTTMAYSNGQYMYSPPAQPSAAHYGYSAAHHQQNQYAQTRGGMFAPPRADGQIGRQDSLGKGLNPPPYEMNQQLPPFTPSSNGSSMPSISTQPQQQQQHHHHQQMMGAQTPVSSSAPQQSPALSQDSFRPPQPPTPTYSYHSSGTPQHSNFPYSTGPSPTLSQQHSPISAGGSMQRMSPAVSQGSMPSIPSNNPAQSPYQYQQRLPLQYGGGQAPVFSNVQNPAGGLALVGGHPAMMSGFNSGHAAAMPHFMGHPQHQPPTANDRPFKCDQCPQSFNRNHDLKRHKRIHLAVKPFPCSHCDKSFSRKDALKRHILVKGCGKAAGDDAKRESHSPKADDLKSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRV2</accession>
    <name>R0KRV2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_102422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022355.1">
        <property type="nucleotide sequence ID" value="XM_008024164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KRV2"/>
    <dbReference type="STRING" id="671987.R0KRV2"/>
    <dbReference type="GeneID" id="19394922"/>
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    <dbReference type="OrthoDB" id="3912356at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="67274" checksum="F908EE27919E1F1E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSW5</accession>
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            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_166795</name>
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        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021608.1">
        <property type="nucleotide sequence ID" value="XM_008023417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSW5"/>
    <dbReference type="STRING" id="671987.R0KSW5"/>
    <dbReference type="GeneID" id="19399931"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
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    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
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        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="250" mass="27896" checksum="4B8D358FD61E4B94" modified="2013-06-26" version="1">MSTESTQSQACCNTPAVVSHGYQPKGDYIQADGLKTYATGPKDAKLGILVVYDIFGFFNQTLQGADILAYTDSQKYQVFMPDFFEGSPADISWMPPDTEEKKKNMGEFFQSKAAPPKTLPRIPKIVDELSQKNGIEKWAIIGFCWGGKIVNLSSMEGTKFKVAAACHPAMVAGDDAPGITIPYIMLPSGDEDKGDVQKWQEGIKVPHVVEWFPDQIHGWMAARSDLSQEKVQRAYERGYKMVLDFFHKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTN9</accession>
    <name>R0KTN9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_36600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008023133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTN9"/>
    <dbReference type="STRING" id="671987.R0KTN9"/>
    <dbReference type="GeneID" id="19404158"/>
    <dbReference type="eggNOG" id="ENOG502SPVM">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_065389_4_0_1"/>
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    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27991" checksum="0690A0AD58152242" modified="2013-06-26" version="1">MALSLEEIIREFRDRERDKHITTAVWYIVVAVALASSGAGPDVVQLYQAAIQQIDLDDQKIVQRRIKEAILKTSALYGVPRSLQALLPLFSTLKDEEIDHYGPRWEAAQADPASRAIHEKTRHEKARRYFDTVWTPAAAQANRDKNFKYHPDLYLLNTQLVYEYYFSEDAILNPVETQMCNIAALICCNCPVQAMWHTRGLINHGGTINQAEFSHELGVAIATLYECKIGDLTPVSQIDFENYPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KUC9</accession>
    <name>R0KUC9_EXST2</name>
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        <recommendedName>
            <fullName evidence="13">Mitochondrial F1F0-ATP synthase g subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_162121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
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        </location>
    </feature>
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            <end position="447"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA80800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="491" mass="54006" checksum="2EA3236F15BC0541" modified="2013-06-26" version="1">MSDLKDRLARLGLSQYHQVFVAEGFDTWETVLDITESDLSSLNVKLGHRRKLQRAIAESRGQASEKPLPINLARAGSTAGSYRSDDSGPESKSKQPESSSTASGVTGAKRKYRRHPKPDEHAPERPPSAYVIFSNQVRESLKGQDLSFTEIAKVVGEKWQVLPAEEREGCERQANGAKEKYYAELAEYKKTPQYEAYQRYLEDFKAKHSVPTKEGKRSKLDTETSTSTRAGSNEQNDQAANRRLSFTQPETNSITQQKPDPNHPVGPSRLPAGPSYTSKPTSPTNRSLSGFNSPRSGEQFSPVSASPRSANTQRDGVFEPPAANSMRDPRLPFDANPYQQPPPFNSDHNHHSSSTPPPPSYTYASHYQAPPDFPSRRTPRESTRLPPLSHEDTTLSSESGHSGQGVPTPNYPEQTLPADLSKTMRMLPQPVPSIGPSPSPLDRPVPPVATSHYPHHSHDYRTQGPLAVLVRAGELASRVADEDAVEHAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5N4</accession>
    <name>R0I5N4_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_35842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008033063.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19404060"/>
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    <dbReference type="OrthoDB" id="60033at2759"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
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    </dbReference>
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        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF2">
        <property type="entry name" value="HISTIDINE KINASE M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="818"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
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        <location>
            <position position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EOA80950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1172" mass="126718" checksum="711BD9EB937B024D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5V9</accession>
    <name>R0I5V9_EXST2</name>
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        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_100946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031569.1">
        <property type="nucleotide sequence ID" value="XM_008033378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I5V9"/>
    <dbReference type="SMR" id="R0I5V9"/>
    <dbReference type="STRING" id="671987.R0I5V9"/>
    <dbReference type="GeneID" id="19394822"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030977_1_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0I600</accession>
    <name>R0I600_EXST2</name>
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            <fullName evidence="5">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">SETTUDRAFT_24478</name>
    </gene>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
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            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA80966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33049" checksum="43791E1D47F8B3CB" modified="2013-06-26" version="1">MPSWQEATAVEKLSSHTYSCTLHDDWCIGTVPNGGFVTGCLLEVVKAHFSTTLAGQNQPHTIALHVEFLRRTQAGPAIFTIQDVKLGRQTTTVHVSLQQEGREEIVAYVTNSNMTEGDGFSYDTEYKPSPPILSVDLSKLEQGTDPTWKLATNMPHAKFRKAMNQIHFHFPQNGRAAVNISDQWVCFSDGSNFTDSSIGFIADMFPQIAEGFREDNANPLWYPTLLMNIDMKKALPPGGVKWLLTRVEIKKVFKGRMDLEVWVYDAEGDLVALSHHVGLIVDASRNTAARRVGDAKI</sequence>
</entry>
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    <accession>R0I9G7</accession>
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        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_44024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008031974.1"/>
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    <dbReference type="AlphaFoldDB" id="R0I9G7"/>
    <dbReference type="STRING" id="671987.R0I9G7"/>
    <dbReference type="GeneID" id="19404896"/>
    <dbReference type="eggNOG" id="KOG3931">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUF7730"/>
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    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
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    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spartan-like zinc binding" evidence="2">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7730" evidence="3">
        <location>
            <begin position="347"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57157" checksum="09842D07BB1FF9C1" modified="2013-06-26" version="1">MLRNGEPFVPVDTLHFRSLLRSRVELLSPRFMLCFRLVSQPVSDAGLSSPRPPVDGRITLPLTLAAVRCHLRALQAPLHEAMHAFFFVTTSCTHLRADDGTDDGSYSVTIHRSFHHDVDSYRAHVWKCDGPCHTQPPYSGLVKRTMNRPPARSDNWWPKHHAECGGSDTKIHEPAPTKKQLQAMTTKERAGRQKNRLDGCITTAPAKQTPDHDARRKLVGLTNDATPPASSYSRDAQSLAAEDLVSPAPPPPSTSPHTGQKRPRSDPEHGSAIQKKLLVDCPICHKAMKPAPETKASSLLAEASPLLRLPLELRLEIYDHLSRAEPKSYPFSRPPISSIDLRAPPTALMATCRSIYHEVLTHFYNNVTFRAVAQTIQRVRFDYIDPTTATALERVKKFDLRLKWNIEPRYLQQHLSKWPYFMSDWLPDIIRLLHRDAKCLTSLTLSVIDRSQGVGWEHKEPLLAPLQKMRPRVVFYLGEVVAAQDEDALKLGLQRHLKLLNNQTGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9S7</accession>
    <name>R0I9S7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_165653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA82215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9S7"/>
    <dbReference type="STRING" id="671987.R0I9S7"/>
    <dbReference type="GeneID" id="19399542"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140157">
        <property type="term" value="P:ammonium import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="43"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA82215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="517" mass="55780" checksum="BCB4E197CE01C7E2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAD9</accession>
    <name>R0IAD9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_165711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030547.1">
        <property type="nucleotide sequence ID" value="XM_008032356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAD9"/>
    <dbReference type="GeneID" id="19399560"/>
    <dbReference type="eggNOG" id="ENOG502SNMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054780_0_0_1"/>
    <dbReference type="OrthoDB" id="5397330at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="244" mass="27350" checksum="882BCEEC9F06C6D3" modified="2013-06-26" version="1">MPIRNPFRRAGASDHPDDLQRNTPDNGFTSTAVSGATPLQLKDAAEYKLSEINDSGVYLPPSPQHEKPTFWHSKSNVSTTSSNHRSLLSENEPFSISRESFDSYRRSFDISARSPVVDNVHETYPRQSLDARRSMDTRRSFDVRRSRATPRSSMQQGRSSESHDEVAEEAFEDVGLNDEPKPQPKKRGIFSRFGDNNHANDKPDDRPSSSHHFSLTGRKRAESGAGSELKPMPKPAPEAAVEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAW4</accession>
    <name>R0IAW4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiotic sister chromatid recombination protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_77830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029532.1">
        <property type="nucleotide sequence ID" value="XM_008031341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAW4"/>
    <dbReference type="STRING" id="671987.R0IAW4"/>
    <dbReference type="GeneID" id="19405417"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022672_0_0_1"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342252" description="Meiotic sister chromatid recombination protein 1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29708" checksum="53C54F9795D6D9C2" modified="2013-06-26" version="1" fragment="single">MRFSLTSTLVATLAASATANSWFGSAVYDKWHESELERWLSDHGIPHPSPSDRKNLQSTVKANWNDKVVSPYTSWDAPTLQKYLTLKGQQAKKGTEKDAKSLAEQVKVYWTETEDSANQAYGNVKDWIFDTWSDSQLKAFADKHGIPVPQPRQRDSLLAAVRDNYQSAAEKAKETANYPGDWLYASWSDSDLKAWFDERGYTVPQPSTRDSMIAALRRQSRLASIQSQDAYASVSSAAANAQQSLSDALLDSWSDSQIKEWADKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBC9</accession>
    <name>R0IBC9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 alkane hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_22657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029371.1">
        <property type="nucleotide sequence ID" value="XM_008031180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IBC9"/>
    <dbReference type="STRING" id="671987.R0IBC9"/>
    <dbReference type="GeneID" id="19402591"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="55412" checksum="E880758BED9771D4" modified="2013-06-26" version="1">MISMYMTHYQQRLVDNAVSTRHGCRPPPTLQIHWPFGLDRLKQIFQADAESRLMELFLFHFRQTGNTLEQKFLGTRVFGTIEPANLEAILFTHARVFGIGRRRDVALPMFGDGIFTQEGAHWKESRDLLRLQLQHKYYDDLEIFRAAVDRLIHVVSECRGTVDLQPLFFRTTFETTTSFVFGKSTSIMKSTYGSKAHRFGAALDTAQEWIIRRLRFAGFYWLIDSREFRQACQDIQAFVDRNVDDLVQKVPTEMKHPKTHSFIQCIAKTTSDRSALRAQTISILAAGRDTTASLLSWQVMDKLRAEIASTCGAGLHPSRDDLMKMSYLTKVLKETLRLYPPVPVNIRTASETTILPVGGGPTRADPVLIPKGSVVAFSLYSMHRRPDLYGMDAELFRPERWDEDMPLKHNPTTLKWGYIPFHSGPRRCLGADFALTEAGYTIVRLLQSFPDLKLPHGEQLELLGVEKQKSTVVLTIAEGCKVDVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0IC63</accession>
    <name>R0IC63_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_96561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029956.1">
        <property type="nucleotide sequence ID" value="XM_008031765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IC63"/>
    <dbReference type="STRING" id="671987.R0IC63"/>
    <dbReference type="GeneID" id="19406248"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013572_2_0_1"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="304"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="503"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA82980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="623" mass="69269" checksum="6F476D32390FC93D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICZ8</accession>
    <name>R0ICZ8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_164684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029008.1">
        <property type="nucleotide sequence ID" value="XM_008030817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ICZ8"/>
    <dbReference type="STRING" id="671987.R0ICZ8"/>
    <dbReference type="GeneID" id="19399204"/>
    <dbReference type="eggNOG" id="ENOG502QSJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_1_0_1"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="216"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="MohdZainudin N."/>
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                <person name="Han J."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
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    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
    <sequence length="463" mass="50280" checksum="15D0BCE5177A5398" modified="2013-06-26" version="1">MLCSDCYMRKVQLEVDEPLAEVKSYSPTEFNELKQSCGIPTSSYPVKQPEPSSTPEPAPNCTSKLTGKSGDTTNIIAKSNSVSTDWLLTFNNQLPASVNETLTGGETICMDNVPKCILRQITSSDTCSSLVKLSGAGVNRVMFSSWNPTVGNRCRNLYAMVGKYICVSPPGQTTPFVPIDTTTTPTTSAGSSYTWSPAPDQATSSFNFTTIWDFPTEAIPIATATLTPPASAYASAIRARTSHCPFLGEDTDKWTEGLADDEYHLRSSDLEPECIDAWDPYCFPVTTGPVLPSPTDIASTCYPTISTIIPEGFVKPPAPINLGTSDNCNKWHVVGQGDTCAILESKYKISHASFMSWNPSLTDTCSNLRTEMAYCVRVWVEAVETPAPSSSSTTRVSVSPSSTSAGPPGPTQSGTFASCTKWHLQKQGMRYMCLYRIYVWHHCEPIPPAQPGCEHGLLEPGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0IDT3</accession>
    <name>R0IDT3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_164736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029052.1">
        <property type="nucleotide sequence ID" value="XM_008030861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IDT3"/>
    <dbReference type="STRING" id="671987.R0IDT3"/>
    <dbReference type="GeneID" id="19399219"/>
    <dbReference type="eggNOG" id="KOG3210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069674_0_0_1"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="285" mass="31312" checksum="92CF69D1AFEF0825" modified="2013-06-26" version="1">MTVTIGTEKVTVGVLALQGAFSEHIQLLRAAASNIAASPLFQFIQVRTPAQLEQCDGLIIPGGESTTMSLVAARSNLLEPLRDFVKVQRKPTWGTCAGLILLAESANRTKKGGQELIGGLDVRVNRNHFGRQQESFQAHLNLPFLGASKEASKSDPYRCVFIRAPVVEKILPSKKAVGIQEGESQREDTVIAPSKTPADDLARKELDCQVEIMATLSTDAAPLQENQEHKHAGAEDIIAVRQGNVFGCSFHPELTDDPRIHVWWLGEVLKAVERRHEFELAHRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0IE26</accession>
    <name>R0IE26_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_33852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028837.1">
        <property type="nucleotide sequence ID" value="XM_008030646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IE26"/>
    <dbReference type="GeneID" id="19403827"/>
    <dbReference type="HOGENOM" id="CLU_2005340_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="124" mass="13920" checksum="3BB6A1CCFDB6DB22" modified="2013-06-26" version="1">MTLFGNNESGYQVDGNFFLQKGDQHAYAGSVTRCDDIIPKDRQGDDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDDDGGSELREVAYKDNKTDLVSIGFVTTFVRSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0IEK4</accession>
    <name>R0IEK4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_22237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028752.1">
        <property type="nucleotide sequence ID" value="XM_008030561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IEK4"/>
    <dbReference type="STRING" id="671987.R0IEK4"/>
    <dbReference type="GeneID" id="19402522"/>
    <dbReference type="eggNOG" id="KOG1534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA83541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="296" mass="33161" checksum="1DF4FB2143D4CC6C" modified="2013-06-26" version="1">MAATARAAEKCPGPAGAGKSTFCTALIQHLQNIKRPCFYVNLDPAAEDFAFEPDLDIKDLISLEDVMDEMSLGPNGGLIYCFEFLMENLDWLTDPLEEVTDDYLIVFDMPGQIELYTHVPILPGLVKHLMSGSLNMRMCAAYLLEATFVIDRPKFFSGTLSAMSAMMMLEMPHINILSKMDLVKGQVAKRDLKRFIDVDADLIEDDPARKKMSPEEERKYRDPASKESLMSGSSFHKLNKAVAELIDGFSMVSFLKLDVQDEDSLGAVLSYIDDAIQFHESQEPKEPRDVEPEADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGH3</accession>
    <name>R0IGH3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_164521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028667.1">
        <property type="nucleotide sequence ID" value="XM_008030476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGH3"/>
    <dbReference type="STRING" id="671987.R0IGH3"/>
    <dbReference type="GeneID" id="19399158"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039949_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="373"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="527" mass="58426" checksum="0A4D9005BA155EAD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGJ1</accession>
    <name>R0IGJ1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_92742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028502.1">
        <property type="nucleotide sequence ID" value="XM_008030311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGJ1"/>
    <dbReference type="STRING" id="671987.R0IGJ1"/>
    <dbReference type="GeneID" id="19405992"/>
    <dbReference type="eggNOG" id="ENOG502QTW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027360_0_0_1"/>
    <dbReference type="OrthoDB" id="5356836at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA84111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="332" mass="37591" checksum="12E5BC390C139E7B" modified="2013-06-26" version="1">MQRTVVTINSNGRQAASFIRVAAALGWQVRAQMRDLNGIVARELAELDNVTVFIGALEDKKFLDDLFRSAQCAFINTTHWGDEVAIGRALADAAKKACIQHYIYSSMPDHSVFGHGWKALPMWAPKFTVEQYVRQIGLPATFVYCGIYHNNFTGLDFPLFCMQHQYDGSFVWQAPFHPDQPLPWLDSEHDVGPAIFQLFKEGPRKWNGKRVPLAFASMTPKEVCKAFSTGLRRPVRYKRGPIMINVPTPAGYREHLAALEYTLGERGAPYFGPDLEPDVPTAALSLWEGNRSMEEYAQEVFPVEEAANGLTWMEEVETPRREIEIDFEQINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGS8</accession>
    <name>R0IGS8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_112635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908738">
        <property type="protein sequence ID" value="EOA84445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027926.1">
        <property type="nucleotide sequence ID" value="XM_008029735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGS8"/>
    <dbReference type="STRING" id="671987.R0IGS8"/>
    <dbReference type="GeneID" id="19395562"/>
    <dbReference type="HOGENOM" id="CLU_098890_0_0_1"/>
    <dbReference type="OrthoDB" id="3692397at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="150" mass="16697" checksum="BA88F05BB9E58117" modified="2013-06-26" version="1" fragment="single">LFPWKDDQRILAGSLWFALDDGDRGVQMAALLDSLSSFILTGTRGLIYSSGLIHFLAVLGIDPEMRRFRTAKNYLYMLAGVVYCTRVLGAAKLLPAVQNSSETDDNYENFLEMRRKYLADGSLSPISEMINLLAYGKHIAHNQGNTGNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGW7</accession>
    <name>R0IGW7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_40286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908704">
        <property type="protein sequence ID" value="EOA84470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027888.1">
        <property type="nucleotide sequence ID" value="XM_008029697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGW7"/>
    <dbReference type="STRING" id="671987.R0IGW7"/>
    <dbReference type="GeneID" id="19404609"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="481" mass="52465" checksum="02A844A7E638DFEC" modified="2013-06-26" version="1">MEPKRPISHEDIERLRELLKDTEAQLVTPNEEDAYTASIRRWSRAAEKRAGACLVPKSTEEISITLKYASEHGLDIAVKGGGHSTAGASSTDGGLLINLKTHLRTTEVDVEKKTIKVGGAVGGTVSDTGVGGLTFGGGFGWLTAKHGLVIDNLIACTVVLADGSIVKASNEDDRDLFWAVRGAGQNFGIGVEFVFQAHETGDLWAGFMLFPPVPDTIQKVVEAFNTIFTPDSDGVTKAVDKASGGFGFVRPPPAGGQVMFFVVVTYRGDEEEGKKLFQDVIAQQPQISTMSMMPYAKANKLMDLPIGARASLKGAAFELPVRSDFVLSVLEAYSKFTDENPDAAGSQVMWELLDPTRLVAVTNFDTAFANRGLHFNAAVAPLWWDEKNDQECRQWSRDVTLLFKHELQRGGAETGESNDGWIGKKGSHGATMVYGNYDQYEERSRDVFGNNYERLQVLKAKYDPSNMFNKLFAIEPKPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHQ2</accession>
    <name>R0IHQ2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_20044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026852.1">
        <property type="nucleotide sequence ID" value="XM_008028661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHQ2"/>
    <dbReference type="STRING" id="671987.R0IHQ2"/>
    <dbReference type="GeneID" id="19402279"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_1_1_1"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090518">
        <property type="term" value="P:L-arginine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090515">
        <property type="term" value="P:L-glutamate transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090513">
        <property type="term" value="P:L-histidine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090517">
        <property type="term" value="P:L-lysine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090516">
        <property type="term" value="P:L-serine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090514">
        <property type="term" value="P:L-tyrosine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="41"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA84506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="501" mass="54645" checksum="92F48773CE8374E2" modified="2013-06-26" version="1">MATYSAISPQPDEADPMSLSTASLRGRRRGRGKQDVRFKGEATWISSVINLANTILGAGLLAMPSALSKMGIFLGIFVIAWAGTTAGFGLYLQTRCARYIDRGHVSFATLSQMTYPNLSIIFDAAIAIKCFGVAVSYLIIIGDLMPGVVQGFAPGAQHITFLVDRQFWITAFMLIVIPLSFLRRLDSLKYTSIIALFSIAYLVILVVAHFIKGDTLADRGTVRVFHWAGPVSALAAFPVIVFAYTCHQNMFSILNEIADNSHFQTTTVIFAAIGGACGLYILTGITGYLSYGDNIHGNIVSMYPTAAASTIGRLAIVILVMFSYPLQIHPCRASIDACLKWRPGRGRKQTEGSPSRASLMNNTTKPGTPKSTEMSDLRFAIISTVLIILSFITAMTVSSLEKVLAYVGSTGSTTISFILPGLFYYKISDPESAHHQRLIKDEDDEDEFQSGQVEGYVTREGHINRDLRRGLLRKLALALSIYGVIVMVTCLITNTFLATTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IK15</accession>
    <name>R0IK15_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_89950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027651.1">
        <property type="nucleotide sequence ID" value="XM_008029460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IK15"/>
    <dbReference type="STRING" id="671987.R0IK15"/>
    <dbReference type="GeneID" id="19405804"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_1"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="63"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA85196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="208" mass="23081" checksum="7E51C9F9ABFE27AE" modified="2013-06-26" version="1">MSDNGEIEVENPTGINILPKDVAEEQGSWSYEEVEVRDISLTDYIQIRSPVYISHSAGRYAVKRFRKAQCPIIERLTNSLMMNGRNNGKKLMAVRIVAHAFEIIHIMTDQNPIQVAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQGISLLTIGAREASFRNVKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0IK65</accession>
    <name>R0IK65_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_154831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027695.1">
        <property type="nucleotide sequence ID" value="XM_008029504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IK65"/>
    <dbReference type="STRING" id="671987.R0IK65"/>
    <dbReference type="GeneID" id="19397441"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000219">
        <property type="entry name" value="Importin subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="943" mass="104203" checksum="E4F3C93A2A25F93C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0IK91</accession>
    <name>R0IK91_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_111787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908692">
        <property type="protein sequence ID" value="EOA85525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026828.1">
        <property type="nucleotide sequence ID" value="XM_008028637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IK91"/>
    <dbReference type="GeneID" id="19395509"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_3_1"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="187"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA85525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51734" checksum="623C338D0E4CA861" modified="2013-06-26" version="1">MLAEEQSTLLQLAKQVQSLTTQIVNDLSEKNIPEPSFATDSSALPESPEHIDLRVRLNDKARDLLRLINGPKNDARTFVCYLYDLTAWQVACEFNFFEAIPENQSATIEEIAQRTGIDQDRAARFLRMLCSDRVFEETEKDVFRHTSRSILYLHDTQWRDVMHYQLDEFFKAASETSESIKQSPTVVNGQTNAFVTRHGKSLFEYYKHDPKRAARFASAMAGVSRLERHFGILRDSFPWGQISGRKVIDVGGGSGHMSVNLARTFPNLELIVQDSLSMLSSASQNDFSDLNGRVTFMPHDFFSPQPVTGAAAYLLRYITHNWSDEDCIRIFRALVPALEKSPAGTPLLINDVVLPALGEASLYQENRMRQVDIMMMLVLGAKQRTEEEFGRLLSNADTRFKIKSIHGKGNMSLIEAYLDVEDSRESALPADAADLGLEPFAAQQHVDALSTSSKRSGARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>R0IKS5</accession>
    <name>R0IKS5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_138139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027844.1">
        <property type="nucleotide sequence ID" value="XM_008029653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IKS5"/>
    <dbReference type="GeneID" id="19396448"/>
    <dbReference type="eggNOG" id="ENOG502SHZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008599_1_1_1"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA85466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="785" mass="87332" checksum="0F30CF319F9EED2C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILU7</accession>
    <name>R0ILU7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SETTUDRAFT_169571</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908637">
        <property type="protein sequence ID" value="EOA85796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026588.1">
        <property type="nucleotide sequence ID" value="XM_008028397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILU7"/>
    <dbReference type="STRING" id="671987.R0ILU7"/>
    <dbReference type="GeneID" id="19400953"/>
    <dbReference type="eggNOG" id="ENOG502SG7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138063_0_0_1"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="89"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EOA85796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="140" mass="15092" checksum="4E48507AD3D523A3" modified="2013-06-26" version="1">MSNFTRPLPTHLRNQSLGGPQQQSPILLARIAEKKAELANLKDLQALSGGLADQMQLLADKLSTLSDGTEAVAAVLSNWHNVLRAINMASAKLPRPKEDDEDEGAKRSEDGPPLPQTLVRIPTQHAPTVMEQANAANAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPN7</accession>
    <name>R0IPN7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_153465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025295.1">
        <property type="nucleotide sequence ID" value="XM_008027104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPN7"/>
    <dbReference type="STRING" id="671987.R0IPN7"/>
    <dbReference type="GeneID" id="19397303"/>
    <dbReference type="eggNOG" id="ENOG502SJY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030125_2_0_1"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF8">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="5"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="393" mass="44440" checksum="6292236F771A3F92" modified="2013-06-26" version="1">MSKSAIVFGASSVTGWSFVNEILSDYPAKGVWKRVHALSNRPITLAQTQWPDDPRLNMVPGIDLLAHSQESLEKELAKALPDVSEVTHVYYLAYKAGLDVHKEMDEVMDMFTKAVKAVDKLCPALEFIVLQIGTKIYGCHLRAMLPWYDEAAPPGTTAPPLPSPPLSESAPRIPSPFAEMLFYHAQIDFITEYAKDKKWSFIETRPDIILGFVPNQNYYSLSTTIGLYVSLWKEIHGEGAKCPFPGTMAVWKALNNDSSSDMIARQTIHLTLSPSTPKGAAYNIADSKTPYNWQTKWPIICSYFGLEAAEPLAEPIDIRQFINDNMDTWLAMEKKYGLQSGHVDGEHLLMTKFDFDRHFDMTKMYSTGFTEERDPKQVWTTVFDRMRKAKIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQ13</accession>
    <name>R0IQ13_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_162961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025401.1">
        <property type="nucleotide sequence ID" value="XM_008027210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQ13"/>
    <dbReference type="STRING" id="671987.R0IQ13"/>
    <dbReference type="GeneID" id="19398606"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05346">
        <property type="entry name" value="SDR_c5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="271" mass="29207" checksum="CBC2ABA1CC100CC4" modified="2013-06-26" version="1">MSTKMAERLKGKTVVITGASSGIGRSTALEFARTQPDDLKLILTARREDSLKELAQEIGGFAKGVQVLPVKMDVSKPEQVSSFVGNLPQEFKDIDILVNNAGLVKGLAQAPDISPADIDVMFSTNVTGLINMTQAILPIFKARPTPSGDIINIGSIAGREPYQGGSIYCASKAAVRSFTDAMRRELIATRIRVIEIDPGQVETEFSVVRFGGDKEKAKKVYEGVEPLTPDDIAEVVVFAAGRRENVVIADTLIFPNHQAAATVMHRKPTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRE7</accession>
    <name>R0IRE7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_163244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025703.1">
        <property type="nucleotide sequence ID" value="XM_008027512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IRE7"/>
    <dbReference type="STRING" id="671987.R0IRE7"/>
    <dbReference type="GeneID" id="19398705"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="111"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA87251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="692" mass="75241" checksum="CC4E0EAFFC00D35E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>R0IU08</accession>
    <name>R0IU08_EXST2</name>
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        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_168652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IU08"/>
    <dbReference type="STRING" id="671987.R0IU08"/>
    <dbReference type="GeneID" id="19400615"/>
    <dbReference type="eggNOG" id="KOG0357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA88285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="548" mass="59693" checksum="A7BFE38DC74CE684" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IV70</accession>
    <name>R0IV70_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_168459</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wang R."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0IZD7"/>
    <dbReference type="GeneID" id="19397859"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF5">
        <property type="entry name" value="UDP-GLUCOSE,STEROL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="260"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="579"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1035"/>
        </location>
    </feature>
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        <location>
            <begin position="1055"/>
            <end position="1210"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="94"/>
        </location>
    </feature>
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        <location>
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            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
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        <location>
            <begin position="1085"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA90085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1234" mass="136630" checksum="98EF3FD2D0B631E2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0J092</accession>
    <name>R0J092_EXST2</name>
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        <recommendedName>
            <fullName evidence="4">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_102329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022073.1">
        <property type="nucleotide sequence ID" value="XM_008023882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J092"/>
    <dbReference type="STRING" id="671987.R0J092"/>
    <dbReference type="GeneID" id="19394918"/>
    <dbReference type="eggNOG" id="KOG1251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801161_0_0_1"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA90171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="144" mass="15498" checksum="C35D22299047CC15" modified="2013-06-26" version="1" fragment="single">RRGVQAGQRIASVKTLTIADGLRTPLGDYTWAVISQPDYVCGLYAVSEQNISDAMKLVLERTKCFVEPSAVVGLATVLYNEDFRAMVQREAGDEGWNVGVVFSGGNTTIEAITKIFAHVPEAKAERHEGVVGRDASSQVENVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0D2</accession>
    <name>R0J0D2_EXST2</name>
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        <recommendedName>
            <fullName evidence="4">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_103668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022293.1">
        <property type="nucleotide sequence ID" value="XM_008024102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0D2"/>
    <dbReference type="STRING" id="671987.R0J0D2"/>
    <dbReference type="GeneID" id="19394995"/>
    <dbReference type="eggNOG" id="KOG1260">
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="31943" checksum="A699A6475E99737F" modified="2013-06-26" version="1">MTAVEKLRAMLADPEKFIACPGVYDGFTARIALQEGVDCLYMTGAGTTMSRLGAADMGIATLNDMASNAAMLASLSPRTPLIADADTGYGGPVMVGRTVSSYIRAGVAGLHLEDQIVNKRCGHLNGKQLVSTSEFEARIRAAVLARDASGGDIVIIARTDALQSFGYDEAITRLRAAIAQGSDVAFLEGVNSAQDAARVCADLAPTPCLFNNVPGGVSPDFSVNQCRQMGYKLAIFPLLACEVVYPAVRKAVQQMKELGNVQSVEEDGRRYGPRELFRVCGMDELIDFDVKAGGLSYKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0X4</accession>
    <name>R0J0X4_EXST2</name>
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        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_124776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA90595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021398.1">
        <property type="nucleotide sequence ID" value="XM_008023207.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0J0X4"/>
    <dbReference type="GeneID" id="19395952"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
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    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="8">
        <location>
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            <end position="500"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="33"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA90595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="516" mass="58107" checksum="69896BEFB00D7D10" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0J181</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_24847</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021204.1">
        <property type="nucleotide sequence ID" value="XM_008023013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J181"/>
    <dbReference type="GeneID" id="19402842"/>
    <dbReference type="eggNOG" id="ENOG502T642">
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    <dbReference type="OrthoDB" id="3681095at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="62" mass="6884" checksum="5B8C5C82F9F1E0DD" modified="2013-06-26" version="1">MSSSQGQQQQSSGGSRPTGATGGGYYRHPCRNWQQEGHPKDYNFIDQNDQLCAHCLCAPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2W5</accession>
    <name>R0J2W5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_166917</name>
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    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
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    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="295" mass="31282" checksum="130E5893C2A240E2" modified="2013-06-26" version="1">MSIKNVIIIGAGGNLGPSILDAFLKTPAFNTTVLSREGSSSTFPSGVKVIRANYDSAKSLKAAFQGQDAVISLVGGTALGDQNKLIDAAIAAGVKRFLPSEYGSDTTNKRTREIVPVFEAKHGTVNYLKSKEGEISWTSIATGPFFDWGLKVGFLGFDQASKTATLYDGGEATFSASNLSQIGAATVKALEHADLTKNQFIYISGFQTTQKDILAAAEKVTGAKWTVKNVSVKEHIAEGTAKLQKGDYSGIPALIQGAMFSKDEPLGDFSSLGLWNDKLGVPKEDFEETVRASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4V6</accession>
    <name>R0J4V6_EXST2</name>
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        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">SETTUDRAFT_162516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J4V6"/>
    <dbReference type="STRING" id="671987.R0J4V6"/>
    <dbReference type="GeneID" id="19398416"/>
    <dbReference type="eggNOG" id="KOG1602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:lipid droplet"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
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        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA91965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="362" mass="41030" checksum="D4AFF7F5B4E08C1D" modified="2013-06-26" version="1">MGSIHDSRIHKWFATSPPVAWTVRQLRELLIGSLKQGPIPQHVAFVMDGNRRFARNHHIETVEGHNLGFESLARILEVCYKTGVRVVTIYAFSIENFKRSKHEVDALMSMAKVKLQQLAEHGALLDRYGASVRILGQRELISPDVLKAVDKAVAMTAHNKKAVLNVCFPYTSRHEITTAVMKTVETYSTPMHTLSNSSKRTFSESHITQHIRKQMLEEDTEGAFEQPELGSASPSKDDASVGDGHSSSTSTAINEPEKDDLSNEPTFLDPESISAQTLNDNMMTADAPPLDLLIRTSGVERLSDFMLWQAHENTSIVFLKCLWPEFDLWQFLPVLVEWQWQQKKKLQEEQHQQRVRGRSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0J592</accession>
    <name>R0J592_EXST2</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA92225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="419" mass="44086" checksum="A0EDCC11026868E7" modified="2013-06-26" version="1" fragment="single">MLHFVFLSLLTSTALGQLCESRLKTHRGSLELSSDFCPVKNDDSTGLSQHHRTPFAVSPNGQFAYLAYLDASGSGVHVQAVNPLTFTPIGKPVTMAHGKEAGGLVAHDDGFALLTNEPMPSGTPNAPPNNTAVAVLYRYTLGKETFKTFLGGPSDDSAGASCSPRLNGDLVYSEDAGMYGAAFTAAGYAGAAKGHSSDSLQYVNENGTITKTAGAADCSRNSGIALEASDSVPFASVCADNKGTLYLNNGAGMNSSRVKIGAATGAMGGASGSYSHLTRFFDTDSYIFTWMSRGAKDSSANRNVAVATSQKAGNMHVTWMTAGKTDCQNARVATFDSSNAIVSWEEIAEGKFTGTYFQQIRDGKKIGKPIKSTNVYVAGDMVNMGDGRVCWPYVNMAWSLDGLASKCPLTKVMSFACMT</sequence>
</entry>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
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    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
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    <dbReference type="OrthoDB" id="3763at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="12">
        <location>
            <begin position="47"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="11">
        <location>
            <begin position="219"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA80768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="515" mass="57110" checksum="87528A7BE5464F9B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0JHV5</accession>
    <name>R0JHV5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_166390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031538.1">
        <property type="nucleotide sequence ID" value="XM_008033347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JHV5"/>
    <dbReference type="STRING" id="671987.R0JHV5"/>
    <dbReference type="GeneID" id="19399785"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024081_2_1_1"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="190"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA80968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="414" mass="46690" checksum="8EA00D6F85BED52D" modified="2013-06-26" version="1">MDGDPAVEPEIDGFTRILPLPYRVAIIIVLGIWAWGLNLHYLSLIKIDVPSLIRYPSRASPHHPPHHLSCYRIAAFLSLPLAFSLFLFWALTHGSTQAIAAWEILPNLYLLVLVIGFIAPVPFISRNGRSRTLGTLKRISTGGIAEAQDGKFGDILLADALTSYAKVLGDLFVSLCMFFSSGHSSTASPNRNCGGTFWVPFIIAVPSLIRLRQCITEYYRVKRANERTGQVNPATGWGGTHLANAAKYSTAFPVIILSALQRTPHPDSFGVSQTTLYRMWLFAVVVNSAYSFYWDIAKDWDLTLFSSAAMRNSPEYPWALRRHRWFHAKEFYYAAIVVDALLRCTWSLKLSPHLDHFNDLEGGIFTMELLEVLRRWIWIFFRVETEWVRNHRGPAPDDILLGDVGAANTYDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0JN81</accession>
    <name>R0JN81_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_34175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029437.1">
        <property type="nucleotide sequence ID" value="XM_008031246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JN81"/>
    <dbReference type="STRING" id="671987.R0JN81"/>
    <dbReference type="GeneID" id="19403868"/>
    <dbReference type="HOGENOM" id="CLU_1476004_0_0_1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="183" mass="19675" checksum="6732A7448C242F4B" modified="2013-06-26" version="1">MPESNTLSVLVVVGVGGMGLTIARLLSRDKFVFLVNFNQANLDTASAALQAMGRECETYKLDVCKYNSVVEFAASTGKVGHVNAIIHTAGVSPVQASAKVIYEVDLVGMANFLRLNGKTPSHSYTRRTAQTCGLRFEPSINEAYTITKKGKLLRAQAATSMYGSKGAGSYEADDQRLGSWASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JRV7</accession>
    <name>R0JRV7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_21200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027994.1">
        <property type="nucleotide sequence ID" value="XM_008029803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JRV7"/>
    <dbReference type="STRING" id="671987.R0JRV7"/>
    <dbReference type="GeneID" id="19402412"/>
    <dbReference type="eggNOG" id="ENOG502RF04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035756_2_0_1"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF10">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE AUR1_IPT1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="183"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="407" mass="46770" checksum="E1258CF81A18AF7F" modified="2013-06-26" version="1">MPNTTLPDNGQWNSKPAWKLPGWCEPVMVASILFFAMFITRKRNYKIFAPLSSRSGYLDSIPNESMDNLLPSSDSDSDLDEAYYAIKNPNAPKIRSLGCCKVTTPSTARFRKNIHSRILQRFPFLIEMFYWIINYAFYRMTAIASSKLFAGRGIWDVAQEHGIAVLEAEQFGPLRFLFPLRERDVQQWFMHGHQDALTVLNKCYALIHIPGTVGFICWYYYVAPSFDTFAIARRTLTLTNFCAFLTFVVYPCMPPRLLPTEYGFLDTVRHDDAQSVWMSGKFVNQLAAMPSMHFGYSFCIGMTLIYHSGLFRRTLEPGEVRKNAFWKIFYLVFGIGYPTFILTVIVATANHYLMDALVATCFVFLSFLCNKVFYVFIPLEDLLLYAIRADKPVPTTGDRFREKGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0JT24</accession>
    <name>R0JT24_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_55644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908881">
        <property type="protein sequence ID" value="EOA80664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031704.1">
        <property type="nucleotide sequence ID" value="XM_008033513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JT24"/>
    <dbReference type="STRING" id="671987.R0JT24"/>
    <dbReference type="GeneID" id="19405214"/>
    <dbReference type="HOGENOM" id="CLU_098890_0_0_1"/>
    <dbReference type="OrthoDB" id="3692397at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA80664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="173" mass="19440" checksum="452ED08A2EA3BF8A" modified="2013-06-26" version="1" fragment="single">MKDARELFPWKDDQRILAGSLWFALDDGDRGVQMAALLDSLSSFILTGTRGLIYSSGLIHFLAVLGIDPEMRRFRTAKNYSYMLAGVVYCTRVLGAAKLLPAVQNSSETDDNYENFLEMRRKYLADGSLSPMSEMINLLAYGKHIAHNQGNTGNAYWSEDKKIFYLNGQPISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JT73</accession>
    <name>R0JT73_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_166186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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            <strain evidence="4">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    </reference>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    <sequence length="163" mass="17414" checksum="A46460F1381D1722" modified="2013-06-26" version="1">MPRMLHRHPHHPLHHTPYTHAAPHHTTRLDASPQHTTPHHSDSILSPSPPTSSHLLHRRLSLHLNFPPLLGPQCLCPVPSIRNASAAGSTRQASPGNDTASSGPGGRERSPKGSTPSTRATTTTTTTTTTTATKCLSDSRRLALQLPTCTGNVGQPLARVTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
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                <person name="Lucas S."/>
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                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">28A</strain>
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        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
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        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
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    <dbReference type="OrthoDB" id="2996783at2759"/>
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        <property type="term" value="P:cell redox homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
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            <end position="172"/>
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    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
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            <position position="51"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA81387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <sequence length="228" mass="25217" checksum="3C37D0BE6232100D" modified="2013-06-26" version="1">MAEGRSEPLRLGSTAPNFKAETTAGPIDFHEFIGDNWVILFSHPEDYTPVCTTELGAFAKLEPEFARRGAKLIGLSANTIDSHAGWIKDIDEISGSKLTFPIIGDKERKVALAYDMIDHQDATNVDSKGIAFTIRSVFIIDPKKTIRLILSYPASTGRNTAEVLRVLDSLQTGDKHRITTPINWVPGDDVIVHPGVSNDQAKELFPDFRIVKPYLRFTPLPKEKTTAA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="10520214at2759"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EOA82639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="315" mass="36448" checksum="9855106D40CC774F" modified="2013-06-26" version="1">MAVMSLASRDPKAVATTRRHLQIDLDNRKLLRVFFSLDYTSMLVAIEMIADGTINSTHFFHKPPCQVGIDSATSAQVPYFVSFLDYLIEFYTRYFPPSKQPEEDLIDDIEIIFMVLSACCSYQADIQIRELANDPDIIANIWHVFAQRLKNLPLDVTQYPLPIQIWVDKTFMRGLEELERLPPSMIRAASASKLAGSAHTLAKPRERRIAFYRLFEILLSTPNIGLIRKAVLSIRHLEHLTDLRPNSFGTIAWRLIDKTYKTASFQIYRAVIKAIGELIGYDEIVVEQWYNECWSRAHPEPWARRRYGSTYRSRT</sequence>
</entry>
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    <accession>R0JZA3</accession>
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        <recommendedName>
            <fullName evidence="5">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_56772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZA3"/>
    <dbReference type="STRING" id="671987.R0JZA3"/>
    <dbReference type="GeneID" id="19405221"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="3774633at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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    </evidence>
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    </evidence>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="1"/>
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    </evidence>
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    </evidence>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0W7"/>
    <dbReference type="STRING" id="671987.R0K0W7"/>
    <dbReference type="GeneID" id="19399227"/>
    <dbReference type="eggNOG" id="ENOG502SBXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129452_2_0_1"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14394" checksum="5AE0D22FBDBCF9D5" modified="2013-06-26" version="1">MPPPLPPPTFLYKILPSAPPSPLPTRLPLSDLDRNDGYIHLSTSEQVPGTADKFFATVGELWLLKIKYDVLAAGTDGDGHVHPDNKAELKWEEVGRGCFAHLYGADLGSGNVESALRVEKKGSWADSLSLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0K141</accession>
    <name>R0K141_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_43199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028868.1">
        <property type="nucleotide sequence ID" value="XM_008030677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K141"/>
    <dbReference type="STRING" id="671987.R0K141"/>
    <dbReference type="GeneID" id="19404834"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_10_0_1"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032302">
        <property type="term" value="C:MutSbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000406">
        <property type="term" value="F:double-strand/single-strand DNA junction binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000735">
        <property type="term" value="P:removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA83399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="934" mass="105006" checksum="BD332F3106D3694E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1M2</accession>
    <name>R0K1M2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_165737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030569.1">
        <property type="nucleotide sequence ID" value="XM_008032378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1M2"/>
    <dbReference type="GeneID" id="19399567"/>
    <dbReference type="eggNOG" id="ENOG502RWG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074627_0_0_1"/>
    <dbReference type="OrthoDB" id="3942467at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="295" mass="31615" checksum="AB731FF0484A1CB0" modified="2013-06-26" version="1">MEPSRPDALQGAKESTLQQTLSSEINSRPASRLALDDLSAPPAYHMVVDSEMSTSTATSPYMHDEEEYDREHDGDHTPEIVINAATQIRGHGNIISIAQMDSVRIANLITSVLNCDELDEATRPLTPPSPPSLATAPPERTSKTQVRGIKRYPNINITVNCGATVIGDRNIVGPGLGDIARQMQMAQRNQAALLAQQQQRQQAAAAAAAMGTPGQSKMASPPLQQRSSNSFFPSQPPFSSAHYATAVHNPPGSHGVATPPMSRSSSLHSDREARKRKAADMGESVAGIAIKKQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1P6</accession>
    <name>R0K1P6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_135640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025585.1">
        <property type="nucleotide sequence ID" value="XM_008027394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1P6"/>
    <dbReference type="STRING" id="671987.R0K1P6"/>
    <dbReference type="GeneID" id="19396320"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030619_0_0_1"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="215"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA87063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="458" mass="50507" checksum="423D8B81B7313F9D" modified="2013-06-26" version="1">MAEKKQRVVFFHPDLGIGGAERLVIDAAVGLQSRGHKVTVFTSHCDPQHCFDEARDGTLDVRVRGNTIVPAAIFGRFAILCAILRQVHLILQIALLSEELQQLAPSAFFVDQLSAGIPLLRLLQPRPRVIFYCHFPDKLLAKKGGLLKALYRAPFDWLESWSTGCSNTIVVNSNFTKSIFAEAFPGLRTREPGVVYPCVDTNPSEPVGQDAPLWKDKKVLLSINRFEKKKDVALAIRAFAGLSPIEREHSRLVIAGGYDARVPENVSTYTELCELADSLQIKHATAKTVTAAQSIPDDISVVFLHSVPNSLKANLLANSRLLVYTPLHEHFGIVPLEAMLVGTPVLAANEGGPTETVVDGQTGWLRDVRKVQDWTEVMHFALEDGHNEQRLKEMGTQGRERVIAEFSKEKLAERLEMEIQTMSRKAVRPPLIPLAAAVLAVVLMGILAALSMVLALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4E7</accession>
    <name>R0K4E7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_160859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027544.1">
        <property type="nucleotide sequence ID" value="XM_008029353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6B6"/>
    <dbReference type="STRING" id="671987.R0K6B6"/>
    <dbReference type="GeneID" id="19401695"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="59665" checksum="6557570E4B77A84D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6U1</accession>
    <name>R0K6U1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_159896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023396.1">
        <property type="nucleotide sequence ID" value="XM_008025205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6U1"/>
    <dbReference type="STRING" id="671987.R0K6U1"/>
    <dbReference type="GeneID" id="19397992"/>
    <dbReference type="eggNOG" id="ENOG502QSY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007426_0_2_1"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="884" mass="97393" checksum="35E1859B78B81B4A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7A9</accession>
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    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_148414</name>
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    <organism evidence="12 13">
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023533.1">
        <property type="nucleotide sequence ID" value="XM_008025342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7A9"/>
    <dbReference type="STRING" id="671987.R0K7A9"/>
    <dbReference type="GeneID" id="19396970"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA88883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="353" mass="41032" checksum="1D7AAC7DBE8C4FD1" modified="2013-06-26" version="1">MALNNSSGATSVARVYADVNANMPRSYWDYDSVNISWGVLENYEVVRKIGRGKYSEVFEGINVVNYQKCVIKVLKPVKKKKIKREIKILQNLSGGPNIVSLLDVVRDNQVSDGSGWLGDWSKTPSLIFEYVNNTDFRSLYPKFQDFDVRFYIFELLKALDFCHSKGIMHRDVKPHNVMIDHEKRKLRLIDWGLAEFYHAGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGAMFASMIFRREPFFHGNSNSDQLVKIAKVLGTEDLFDYLDKYDIELDAQYDDILSRYPKKPWHSFINAENQRFVSNDAIDFLDKLLRYDHQDRLTAQEAMAHPYFAPVRQAAQQNSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7C1</accession>
    <name>R0K7C1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_160071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023539.1">
        <property type="nucleotide sequence ID" value="XM_008025348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7C1"/>
    <dbReference type="STRING" id="671987.R0K7C1"/>
    <dbReference type="GeneID" id="19398006"/>
    <dbReference type="eggNOG" id="ENOG502RY0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026939_1_0_1"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="60"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA88893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="504" mass="56642" checksum="94B8778D33682654" modified="2013-06-26" version="1">MATNATSTDALRGGCPAPFYDQARFGFNGFVDGRFCVPYTDGIVCCLPCPLTDVLYPESFNTTYQVAEALNVVGLVCLVFMLITYVVLPPEKTRRHYLSYCLILAAIFMALGFVIPFGAQPEQCYDEITPNDMYSSLTCAFSGAFLISGGLSMAVWIFIRALSMHLQICWDVTPGKKFFYCAQVFGWSVAAAFFTVTITITGVSFRFGDVCHVNASHSMQDFWGPLLAISGAATVIQVATFVYCIKVYLQNMFSDDKTDTQSSAGFPSYTTSIRNHSARAVYRRVRKVLYLQWRGITIVIFILVDVVFFSIVFIWLNSVTKNATDKVTELYPYILCLMDNSENPAPCFELGQEIAIDQSTVTAVLIMLSVAGIQVFLLLGRWSMITGWRDFFRDKFSKNREFVSLDARNPTDDMRQFELKNFEHQMPPNAHVAPELASYPMDNPRSDTPEHFQKEIQRDYKSPTLSFSTPRPQSRAAPQIEWDPRSSMARGGLGLHPPDYDSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7C7</accession>
    <name>R0K7C7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_42848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028166.1">
        <property type="nucleotide sequence ID" value="XM_008029975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7C7"/>
    <dbReference type="STRING" id="671987.R0K7C7"/>
    <dbReference type="GeneID" id="19404797"/>
    <dbReference type="eggNOG" id="ENOG502T05Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1161339_0_0_1"/>
    <dbReference type="OrthoDB" id="5243686at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="249" mass="28170" checksum="6435C792EADC873B" modified="2013-06-26" version="1">MKNYATGVPNMPRYAFRIDEICESDQVAPTVTTGRGDWIPSVQHGANNSVPHNVGSQNVSYRWWVFDGTQIRESPVKPPNTQPYQTYSVFYNGGFGFWVLKDDATNPRREAAWQPLCFEHNLQDGSSYLCDSAQHRTVACRKHGQHWLQMLLPDIHYRGVPFVHSQALGGGLKGDLALFLALVALAAEPTQLPNVLPRICVNGTWQQQLGVGVSDGWLSKRGVVVYVHTYPPWTSADLRRYERSYTYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7E7</accession>
    <name>R0K7E7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_160094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023556.1">
        <property type="nucleotide sequence ID" value="XM_008025365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7E7"/>
    <dbReference type="STRING" id="671987.R0K7E7"/>
    <dbReference type="GeneID" id="19398009"/>
    <dbReference type="eggNOG" id="ENOG502S0CB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085801_0_0_1"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="210" mass="23339" checksum="2096BD0CE92914FC" modified="2013-06-26" version="1">MALAPKFAGQKLASAAVQPKAVHTLEIYLDYTCPFSAKMFKTLYTSPLRKSLLGTYGNRLVTIFRQQIQPWHPASTLVHEAAYAVQKVDSTKFYDFSEKVFEQQKDFFDVSLVNETRNQTYRRLAKIAGSVGVDESKVYGLLEIGDKPGENGSLNAGNGVTNDVKVQVKANRMTGVHVTPTVVFDGVVANEISSGWTVEQWEEWLAKSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7I3</accession>
    <name>R0K7I3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endo-1,5-alpha-L-arabinanase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_92519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028590.1">
        <property type="nucleotide sequence ID" value="XM_008030399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7I3"/>
    <dbReference type="STRING" id="671987.R0K7I3"/>
    <dbReference type="GeneID" id="19405978"/>
    <dbReference type="eggNOG" id="ENOG502SM7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_2_0_1"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18828">
        <property type="entry name" value="GH43_BT3675-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046780">
        <property type="entry name" value="aBig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20578">
        <property type="entry name" value="aBig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA89463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1034" mass="111962" checksum="563F625C70A65091" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9T8</accession>
    <name>R0K9T8_EXST2</name>
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        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">SETTUDRAFT_137291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9V8</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343901" evidence="1">
        <location>
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            <end position="77"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="77" mass="8339" checksum="ECF5AEBCF51F50BF" modified="2013-06-26" version="1">MKFQAIILFFAATAFAGQCRSRGEKFTQSHAELPEATDKNNVFSYCPNAVGCCTDGSVWYACKTVSPSSSVSMKLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9X8</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0K9X8"/>
    <dbReference type="GeneID" id="19401965"/>
    <dbReference type="eggNOG" id="KOG0761">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1747031at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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            <end position="165"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="425" mass="46904" checksum="A25F413C09907F99" modified="2013-06-26" version="1">MATATARAQEADADPASDVSLGQKMLSAVSGSLLTSLLVTPLDVVRVRLQSQESVSTAPSRQSPATGSTLAQFRHVPPNLGISACCREVFWMNNKAPFCVAGPTMAPINPADLNCAVEEVERRTINSTWDGLRKIAQNEGPRTLWRGLSPTLVMTVPANVIYFAGYDWLRTANASPLRQNIADPYIPLVAGATARVLAAIAVSPIEMFRTRMQAAHHPASAAGHFRETLDGLRTMVADQGVLSLWRGLTLTLWRDVPFSAIYWWGYETTRNALTDQRGRRQARDGGFEFRMGRGEQMTQRRSRSRSQENHRDTLVDSFVAGAASGAVAAFVTTPFDVGKTRQQVVRHVGDAARDAARSTRPEDKSIPRFLMHIYHEQGMPGLFKGWAARCLKIAPACAIMISCYEFSKKIALDMNERREHERHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
    </protein>
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            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0K9Z7"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="K Homology domain, type 1"/>
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    </dbReference>
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        <property type="entry name" value="KH_dom"/>
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    </dbReference>
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        <property type="entry name" value="KH_Mug60-KHD4"/>
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        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
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            <end position="650"/>
        </location>
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            <end position="722"/>
        </location>
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        <location>
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            <end position="20"/>
        </location>
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            <end position="869"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="991" mass="109959" checksum="6D6C6FE127CEEC0E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCK5</accession>
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        <recommendedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_144576</name>
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    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA90618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021416.1">
        <property type="nucleotide sequence ID" value="XM_008023225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCK5"/>
    <dbReference type="STRING" id="671987.R0KCK5"/>
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    <dbReference type="OrthoDB" id="191139at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90618.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27508" checksum="3742AADFA6EE50CE" modified="2013-06-26" version="1">MARIFITGSSDGLGSAVAKRLIANGHSVVLHARNAQRAKDATAACPGAETVVVGDLSNLSETKAVAEEVNKLGTFDTVIHNAGLYYGPYRKTPEGIPALAAVNTVAPYVLTALINRPKRLIFISSSMHQNGSPDLGDVLWTKRGEAAYNEDAAYCDSKLHNVMFAKAFARRWPDVKSNSLDPGWVPTNIGGSSAPDSIDAAIESYVMLAEGDEDKAKQSGCFFQPSKREGTPHTGTEDAQAQDKLLEICAEFSGVKLP</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
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    <dbReference type="GeneID" id="19395453"/>
    <dbReference type="eggNOG" id="ENOG502QQSW">
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    <dbReference type="OrthoDB" id="2316594at2759"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051162">
        <property type="entry name" value="T4SS_component"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJGR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52620" checksum="713829298788DA77" modified="2013-06-26" version="1">MPENLAADRGGCVRKDSLTSRYGILSDTNLLVSDDSEQNDTGYIQLHERATQIRHAPILGMDVILQNDQHLIPQYGLIGLYGEAKNIRSKLFLNTNVPFSMFLCGVQGSGKSHTTSCILENSLIPSKHLGELQNPLSALVFSYGHFSGDGIGFSISEAAFLASSGSNIPSAAHVKKVHVLVSPSNYVRISKLYLQLPNVSVTPFKIKPRNLDITTILTLMNVNDSEETPLYMAQVTQILREMSTTGEPFDYRAFKLHLKKQKFNPAQTNMLQMRLSLLESFLDMTDTSPEMVFFPGEITIMDMSCPFVDANTACVLFEIGLQQYLHSQGAGKMIVLDEAHKYMLKIPGAKSLNEALLQTIRLQRHHGARVVVSTQEPTLLTDLIALCSVTVIHRFSSPEWFSAIRRHIPITDESRNDLMRRIESLKTGQAIVYSPNTVLGFDDYGKLIMGTSGMINVRVRRRLTSDGGQSVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDC9</accession>
    <name>R0KDC9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_19908</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="R0KDC9"/>
    <dbReference type="GeneID" id="19402252"/>
    <dbReference type="eggNOG" id="ENOG502R8ZK">
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    <dbReference type="OrthoDB" id="3680815at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <begin position="418"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="EOA86827.1"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
    </reference>
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        <text evidence="4">Component of the ribosome.</text>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
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        <property type="entry name" value="Ribosomal_eL8_euk"/>
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    <dbReference type="PANTHER" id="PTHR23105">
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KHI6"/>
    <dbReference type="GeneID" id="19405333"/>
    <dbReference type="HOGENOM" id="CLU_013929_17_1_1"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
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    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
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        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA87517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="141" mass="16301" checksum="ED892A2526589D34" modified="2013-06-26" version="1" fragment="single">MTAIENALAAINSQGPEGQISYRAAAKIYGVAASTLTRRHQNKTRSRAAAAHPRRLLSPQQEKYLVQHIEKLSERSTPPSREMIKKYVANIAKRQPSNSWVTRFLRRNREKIITRNTAGIDQNRKKADDFEDYHNYFRLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0KIC6</accession>
    <name>R0KIC6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_168915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024666.1">
        <property type="nucleotide sequence ID" value="XM_008026475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KIC6"/>
    <dbReference type="STRING" id="671987.R0KIC6"/>
    <dbReference type="GeneID" id="19400722"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016134_0_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF3">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="280"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA87797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="615" mass="68102" checksum="77BA59C75A22DA2E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0KIE7</accession>
    <name>R0KIE7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_28113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024540.1">
        <property type="nucleotide sequence ID" value="XM_008026349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KIE7"/>
    <dbReference type="GeneID" id="19403214"/>
    <dbReference type="HOGENOM" id="CLU_1511353_0_0_1"/>
    <dbReference type="OrthoDB" id="3755201at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="192" mass="20438" checksum="1BD42896A0841D49" modified="2013-06-26" version="1">MPKDSSGVRHTGAQGLFDDVDEMAQIAQIAQIAQRAAAANTDAYEMHGVQSRARRDQWYAGDKEATVGRRMAWDSRVSRFFGKITGKKAEDDDEDGTKDLVANMVAMAGGIAAGVGGGSQQNHNRGGGGSVSYSIARGAHGHEHMCREGEVEALESPWLKECGMVRVKSSVPGGCQIVSKNMLQRDDGGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJ16</accession>
    <name>R0KJ16_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_108579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908559">
        <property type="protein sequence ID" value="EOA88012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024504.1">
        <property type="nucleotide sequence ID" value="XM_008026313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJ16"/>
    <dbReference type="STRING" id="671987.R0KJ16"/>
    <dbReference type="GeneID" id="19395311"/>
    <dbReference type="HOGENOM" id="CLU_013929_15_0_1"/>
    <dbReference type="OrthoDB" id="5425161at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="170" mass="18996" checksum="D6F5BB59499F1A8E" modified="2013-06-26" version="1" fragment="single">VGGYRLLIIDGHESHCSIKFQDLCKEKNIILLCMPPHSSHLLQPLDVACFSPLKRKYGDAVSGLARNRTHYISKETFLLAFKAAFEQSITKENIQAGFRGAGLVPHDPQAVLSKLDVVVQTPVQSPRRTAAWQAQTPRNAREVEAQSTLIRQRVRNRPRSSANSLDEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJ59</accession>
    <name>R0KJ59_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_127743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023035.1">
        <property type="nucleotide sequence ID" value="XM_008024844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJ59"/>
    <dbReference type="STRING" id="671987.R0KJ59"/>
    <dbReference type="GeneID" id="19396023"/>
    <dbReference type="eggNOG" id="KOG2928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018596_2_0_1"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="255"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="520"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA89194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="591" mass="66356" checksum="8F1086B0A0362907" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJB1</accession>
    <name>R0KJB1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_175986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023332.1">
        <property type="nucleotide sequence ID" value="XM_008025141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLR4"/>
    <dbReference type="GeneID" id="19404333"/>
    <dbReference type="eggNOG" id="ENOG502QQGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="31"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="445" mass="48291" checksum="ACED42E5D246BE4E" modified="2013-06-26" version="1">MKLPPIILENSDALKKYIENATDPATSNPALPAAMIHIVDAQNKVIFSHGASPSKPPTSESIAIIQSLTKIIGAVAYMQLVERGLASLDDPSTITTHLPELAAKQVLTGYTVDPETGKKHWQLEDRKGDITARMLLTHTYGGGHTYFNQLLYDYVRDLGDGVWEKANEATDPYGVLLASPLLWHPGTHTNYGQGLDWVAVLIERISGTSLDGYLEENIFQPLGLREIGTEPAFGGTVTARAENKGKFWPRQMRSEGNAFVTIDAAEPDVVRRSEAFPTGKHHAGCLGTGLVASPRDYASLVTALLPQNNGVHPASSHRLLSPESVAEITKPQLSDGLRNDSRSLPASDAAPILLPVDLSVPHLDPEGSYGFGCGVQGAQRRLKSGKRGRSKGTVYWYGAPNCDAWIDVEKSIVVAVWGSYYPWNDAAWIEFVAGVEELIYEGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLY6</accession>
    <name>R0KLY6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell wall protein YJL171C/Tos1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_106109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023585.1">
        <property type="nucleotide sequence ID" value="XM_008025394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLY6"/>
    <dbReference type="STRING" id="671987.R0KLY6"/>
    <dbReference type="GeneID" id="19395148"/>
    <dbReference type="eggNOG" id="ENOG502QSI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030276_0_0_1"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="346" mass="38511" checksum="BA766654B6C6F754" modified="2013-06-26" version="1">MNVSQLAVYQLPGEAQRMQKRRTVPFYNRRRALKEQETLCNTTDSTNSARLANIQHDDHMSLDTLFQRPNGQAYVSPTSPTSLGARQDSKRQGANWRRVAYYTSSAPAQATGLSFMANLGDPAKSGTFDYAFGNSLSYVAPQGDKVAAESVPFEGTLRTSETEIVVLSDKECDAGCPYWRPNATSHCMLNGWSGSSKAFFIEFQMDHYPNKGTDQGLLSDAPAYWFLNAAIPRALQYGNDRNNVPCSCWSTGCGEFDAFELLSKGAERAKSTIHRQGNIEGGDSNWFRRPVGRKMKFGVVWHYPHITALVLEDDFDFSAQMTGESIQRLVAYDADSWVHSLYAIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0KMJ1</accession>
    <name>R0KMJ1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_167715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022993.1">
        <property type="nucleotide sequence ID" value="XM_008024802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMJ1"/>
    <dbReference type="STRING" id="671987.R0KMJ1"/>
    <dbReference type="GeneID" id="19400279"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_1_0_1"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA89137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="328" mass="34515" checksum="7BB96DD9EF0CEE80" modified="2013-06-26" version="1">MQSIRQPLRSALSKAATRQYATASSQYAETIKNLRINSDTKVLFQGFTGKQGTFHAQQAIEYGTKVVGGTNPKKAGSQHLGLPVFKNVADAIKETQASATAIFVPPPVAAASIEEAITAEVPLIVTITEGIPQHDMVRITDMLKTQSKSRMVGPNCPGIIAPGQCKIGIMPGFIHKRGRVGIVSRSGTLTYEAVNQTTQAGLGQSLVVGIGGDPFSGTNFIDCLKVFLKDEETDGIIMIGEIGGSAEEDAADFLKEYNTANKPVVSFIAGISAPPGRRMGHAGAIVSGGKGDANSKITALEAAGVTVERSPAKLGSTLYDQFVKRDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0KN73</accession>
    <name>R0KN73_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_167344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022342.1">
        <property type="nucleotide sequence ID" value="XM_008024151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KN73"/>
    <dbReference type="GeneID" id="19400144"/>
    <dbReference type="HOGENOM" id="CLU_057547_2_0_1"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="280" mass="31194" checksum="4AA3881577BDEA08" modified="2013-06-26" version="1">MSASSKERKFYLRAPGLEYRLNGPIQIGNVITDMTRPQDPITFLDPLPETISGAGFGEGSTEQGHHASGNIGFAAKLHSIFSAQVEGKSNSSDKTVYGFQKILARYLQRNPSVADVKRFWEKDEEFRNALKSGDVYIVTGLKIAKGLKYSKQRASEHNASIKGGGHVAEGAVIEGTIEGATGGEQSDTWTVLGDVILAYRLHRVRNKWSIRRKNNLATESYDPGEAGFMNRGDEADELEGEFAEVAPHDVDEFAQEQYWELDYMELEDEEEDWKIAVLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KN89</accession>
    <name>R0KN89_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation diffusion facilitator 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_147826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023176.1">
        <property type="nucleotide sequence ID" value="XM_008024985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KN89"/>
    <dbReference type="STRING" id="671987.R0KN89"/>
    <dbReference type="GeneID" id="19396934"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_10_1_1"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="199"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA91534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="262" mass="27587" checksum="FAA011BF9A22C8A0" modified="2013-06-26" version="1">MKIADRTFLISGGVSGLGLATARALHQQGAYVSLLDLNADNGSTIVSELGARAKFFETDVTDTQAITAAVQGTVAWVKETGKHIGGVVAGAGVGLPGLIIDKKNEPLSIESIDFVLNVNLRGTLDLIRQTLPHITTAPPADADGSRGVIIMIASSAAFDGQMGQVAYAASKGAVASLTLPLARDLSKYGIRAVTIAPSMFDSAMTRMMTDKVRKSLENSMEFPKRPGQADEFARLVVECIGNDMLNGTVLRLDGAMRMPARL</sequence>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19403393"/>
    <dbReference type="HOGENOM" id="CLU_1503695_0_0_1"/>
    <dbReference type="OrthoDB" id="4806096at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="170" mass="18975" checksum="5CD0B3295CFD7033" modified="2013-06-26" version="1">MFWFLLFLISLASCSPTKDLVKRGLSCDLFPSSSADLPVFHLNVGNMIRQNVFPVDHTPSLQELPLRTWAYSGPGHHITFRAWRSADQQGEYGSGYWANFEIQVTAPLSLFVNFAAQSRRSGSDPGLSQISNRIAEGSGSSLYPRRTTYSVYVGNIHQNVGFTATGNWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRR1</accession>
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        <recommendedName>
            <fullName evidence="2">DUF8213 domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_86028</name>
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    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SN55">
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    <dbReference type="OrthoDB" id="3660917at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF8213"/>
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        <property type="entry name" value="DUF8213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344117" description="DUF8213 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8213" evidence="2">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="150" mass="15036" checksum="5B0FC8013D7FAFE0" modified="2013-06-26" version="1">MHVLSFYLTALLAVGVSASPTLEKRAITCLTVGSTATATWTNAAGRTCCWTGIVGSNFGVNSVNGGEYSCNGRCGAGCSGFALGNAYTQDCFSHDVCSWFNNASGGASDPNCGAAYNAAVDDTLGGAAAGCGRTNPSNPAVRPSTQPTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KVR5</accession>
    <name>R0KVR5_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_30355</name>
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    <organism evidence="2 3">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
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            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
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    <dbReference type="EMBL" id="KB908844">
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    </dbReference>
    <dbReference type="RefSeq" id="XP_008029645.1">
        <property type="nucleotide sequence ID" value="XM_008031454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAT6"/>
    <dbReference type="STRING" id="671987.R0IAT6"/>
    <dbReference type="GeneID" id="19399341"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_0_0_1"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA82535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="428" mass="47094" checksum="552C19B87BDE0875" modified="2013-06-26" version="1">MYSFCDQKGYDVIDLDPYGTAAPFIDAAIQAINDDGMLCVTCTDSAIFASHGYLEKTYSQYGGLPFKGEPCHEGGLRLILHAVASSAARYGMAIEPLLSLSIDYYIRVFVRVRKAPNDVKLLAGKTMLVYHCESGCGAWSTQFLARNKVTKNKNGDPMYKHGFAQGPSADQHCQHCGHKTHLSGPMYGGPLHNVGFIERVLAQLNEVDRQTYPTMDRIEGMLHTALEEITFGEKLEKANGAQKTQVLDPLIPKADPAELDHHPFFFIPSSVAKVVHCSAPPLAALRGALRHAGFRVTMSHCKPGSIKTDASWKDIWHIMLEWVRQRAPLKNALKTGSPGHAIMEKANSTGYTRDTAAQVSATSAPAAPDNAEIVADGSDTTETKLPAYLNTKFEVNFDEKLGKDHDRGKYVRYQLAPRENWGPMSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICB1</accession>
    <name>R0ICB1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_96523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA83015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029984.1">
        <property type="nucleotide sequence ID" value="XM_008031793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ICB1"/>
    <dbReference type="GeneID" id="19406244"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="88"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA83015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="478" mass="51321" checksum="1FDF9A1B1B0072EC" modified="2013-06-26" version="1">MDPTALDPNSPAARSATPSTTLDEKPTQQPSLASSDSLQSTQVLAADQLQEKDPYVADSSGSAPLEPVRSAHPSVRDPSAIPDGGLWAWLQVLGSFFLLVNSWGIINTFGSYQAYYETTLLKDSSSSSISWIGSIQAFLLMEVGALTGPIYDAGYFRELLIAGSFLLVLGQMMLSLCHTYWQVLLAQAFCIGLGTGCLFVPSVAILSTYFSTRIGTAIGIAVSGSSFGGVIYPIVFHKLLPQIGFAWTTRVLGFLVLGTMVIPNLCMRVRVLPAKSRSLLDLKAFLIPAYSLQVAGFFVGFMGLYMPFFFAQVYALQQHITNDQLAFYLLPIMNSTSLFGRIVPNLLSDKLGPFNVIVPCGLISCVLCFCFMAVSSPSGIIVLMAFYGFFSGSFVSLPPTIVVFLSKDARDKIGTRLGQSFGIVAIGLLIGAPIGGAIQGHRGFDSLWIYGGCLLFAGAVLLFCARVTLRGWSVMAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IEW7</accession>
    <name>R0IEW7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_140327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029286.1">
        <property type="nucleotide sequence ID" value="XM_008031095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IEW7"/>
    <dbReference type="STRING" id="671987.R0IEW7"/>
    <dbReference type="GeneID" id="19396553"/>
    <dbReference type="eggNOG" id="ENOG502R8TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033093_2_1_1"/>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49821" checksum="5E23907E035864E6" modified="2013-06-26" version="1">MEGQSFFDQASAGFRACLPDLSSPRFTTAAKQNVYEYVQSMQDNRAPPWLHDLTKVWEKLLEEPYKGLTNDGNVRSGLFKAQDEGADVGAAVAKAEELLSGLDDEKRKKISYPINAREWRAWSNPEFLLRPFGLRLEEVPESTAKSILAVVEASLSPEGHQKALSAMRISHFLGEVVKLPNIMNKYSYNFLLFGTPSTSASSPWGWLIYGHHLDITCFFKGSQVVLTPSFTGAEPNIIDEGEWKGTQILHKEGNLGLELMQSLNTEQQQKAQIFKNLRDEGMKQVYGKSNNDASKRDELITDTWGPDDQRHRCGAFRDNRIVPYEGVSVSTFNSAQQELVLSICHEFLLYHPSKARERKLQQIRQHFTETYFCWIGGFGNHDAFYYRIQSPVIVVEFDHHSGVFLTNKEPAKYHTHTIVRTPNAGDYGQAIREGHEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGL6</accession>
    <name>R0IGL6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_164551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028694.1">
        <property type="nucleotide sequence ID" value="XM_008030503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGL6"/>
    <dbReference type="STRING" id="671987.R0IGL6"/>
    <dbReference type="GeneID" id="19399167"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184680_2_0_1"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="68" mass="7881" checksum="60A8D54D6614437A" modified="2013-06-26" version="1">MHLMYIADPADPSKRIYTLKKIINGQVSKSAHPARFSPDDKYSRHRVTIKKRYGLLLTQQKNKVAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJB5</accession>
    <name>R0IJB5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_163929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027691.1">
        <property type="nucleotide sequence ID" value="XM_008029500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJB5"/>
    <dbReference type="STRING" id="671987.R0IJB5"/>
    <dbReference type="GeneID" id="19398950"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071454">
        <property type="term" value="P:cellular response to anoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA85250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="337" mass="36299" checksum="0F5515EC14865CFB" modified="2013-06-26" version="1">MTSSLPGNRDLPVSQFDLSTYWGRVRHSANISDPRTLLTSSAGLENAKKLVTAYKTGKMPEMTPELWNAKKIIDSTLHPDTGKPVFLPFRMSCFVLTNLVVTAGMLTPGLGTAGTLAWQVTNQSVNVGVNFSNANKSIPLSTSTIVKSYLLAVSASCGVAVGLNALVPRLKRLSPNAKLIAGRLVPFAAVATAGALNVFLMRGEEIRQGIDVYPALSEIERHRVETGDLEVKPLGKSRKAATLAVGETALSRVLNATPIMVLPPLVLVRLQKTEWLKQRPRLVTPVNLGLIFTTSIFALPLALAAFPQRQAVSAKSLEPEFHDRGGKDGLVEFNRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IKQ7</accession>
    <name>R0IKQ7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_177711</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908659">
        <property type="protein sequence ID" value="EOA85635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026717.1">
        <property type="nucleotide sequence ID" value="XM_008028526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IKQ7"/>
    <dbReference type="STRING" id="671987.R0IKQ7"/>
    <dbReference type="GeneID" id="19401551"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA85635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="165" mass="17621" checksum="C7975175C69FCEB3" modified="2013-06-26" version="1">MNSLRVARAALRARPAAIARPLQRRGYAEVANDKIKLSLALPHQSIYKSQDVVQVNLPAETGEMGVLANHVASIEQLKPGLVEIIEEQGGSKQFFLSGGFAVVQPNSVLSINAVEGYPLEDFSAEAVRNQIAEAQKIASGSGSEADIAEAKIELEVLESLQAAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IL58</accession>
    <name>R0IL58_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_169574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908637">
        <property type="protein sequence ID" value="EOA85800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026591.1">
        <property type="nucleotide sequence ID" value="XM_008028400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IL58"/>
    <dbReference type="STRING" id="671987.R0IL58"/>
    <dbReference type="GeneID" id="19400955"/>
    <dbReference type="eggNOG" id="ENOG502QRB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034574_0_0_1"/>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="331" mass="36982" checksum="737957B936886F91" modified="2013-06-26" version="1">MRRLFSRHRRADDSAISRNTSPTAVPELTKEQVKRATRKRKSWALATSFFLFVTFIFLILVNIAGVRNKPVIRNWYFLRLDLSNIVPATVPNFALINTIAQTLGLHDFYQVGLWGFCEGYKGQGVTFCSKPTNLYWFNPVAILRNELLAGASINLPANINDILDLIHLVSNWMFGLFITGTVLSFVLIFVMPISVYTRWLALPVAILAFLNALFVTVASIIATVMFVIFRNTISGVAELNIGAEIGTTLFAFMWVASAFAIFAWLVQMGLCCCCASRRDVRKGKKRGSEKAYQPDVSGAENGGVRDDNPVVSGASENEKAEKKKYAFWKRG</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the PER33/POM33 family.</text>
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        <property type="project" value="EnsemblFungi"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="71" mass="7728" checksum="8E88B114AE271584" modified="2013-06-26" version="1">MVHRALCLCSTGCRGTSLKSCSPGLLVRAFLHQQDSTFRICSRSVLKVVSSNEKKKKGVLEKAICNEESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IMT6</accession>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="188" mass="21375" checksum="9CF10DA03F855C45" modified="2013-06-26" version="1">MSHNHSQSQASAGGPVQGPGPVPQPALDDEMLTPSDDEDDDDARNLRELRNLRRQATITQRQMASMQDMINQLSSQLMATPNEKRSLTKPKIAAPEKFDGTYTELWTFLTNIDLYCEYNRVPTDQDKILVTSTYMKGRAAKWIEPYVKDFLKDADNLGTKSETRGIFGNWDNFKKEIGRIFGEIDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPA1</accession>
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        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_153378</name>
    </gene>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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    <dbReference type="eggNOG" id="ENOG502S91F">
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    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="21444" checksum="2E094D2EC10F1466" modified="2013-06-26" version="1">MASPQPRRIIKRHHDDDEEALDNAKRRKRSDSQTSSQFELSDEDRLLLKLKEQDSMPWKDIAARFQSELQKSYQIPALQMRYKRLRERMRVWTDVDRKALRMAHEYWVQNKFEIISQKMLEFGAQEKWTARQCSRQWQMMDHPPIPYSQFEPHLQHGFAPYAMSPVEPSSSNGPLFLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPA7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_162810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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    </dbReference>
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    <dbReference type="GeneID" id="19398548"/>
    <dbReference type="eggNOG" id="ENOG502RPYR">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040833_0_0_1"/>
    <dbReference type="OrthoDB" id="5229512at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="459" mass="51235" checksum="7F9BC0CBD142D441" modified="2013-06-26" version="1">MSGTEDDSETASGAAFPFLRLPLELREQVYSHYFHPGDHLVQNADLEARGFYGGVYRWDLSVLHVCKQVYAESKKVWRRENVFVKVATPWPSAVLVNHISSEGLVPIVCTDAKADAFADHHAVVQITAPFHGVVPEHTVVMLVDDLHLFTKTWYYSALSYPMLNERLSTTFILRNPAKTGTEFSHDDDDDVAAATAPGQKEGLGVPIALQKKLLLPFEHVKGLHGIRIYGYSSSVKAELARLQALPVPSLQESLESATDLMAAGDAALATHTPSKEDAAQRALDLYKQAFHAIHILIHGRSRRVLADVFFHDTIPSGRYAGQTGLTVRVILRLKLVARTIAAYNQLAQWHESAFWGMRSAHILDDNFNPDFEAFLTNVLGAADVALIYLRTAIAFWHMETHKEDWLGELIAYADEEMADSIKLWAKARAFLFRISKNEVRAELKAYGVPQDVMEVFTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPP7</accession>
    <name>R0IPP7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_134931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025303.1">
        <property type="nucleotide sequence ID" value="XM_008027112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPP7"/>
    <dbReference type="STRING" id="671987.R0IPP7"/>
    <dbReference type="GeneID" id="19396281"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA86676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="409" mass="44917" checksum="415771041B1430B3" modified="2013-06-26" version="1">MKLLKSQIEQKTGAGFATLLPEEPEDMWHAFNLIQEHDQIRAKAVRRVSKTSEAGSTSSQRITLDLTITVTATDFDIGSEQLHVSGRVAKENEHVKLGQHHTLDLELNRKFTLEKADGWDSVALEQLKEACDASKRAELWAVVLGEGTANICMITEHQTILRQKIEVPVPRKRKGGVDGHAKGMERFFATTLSTLLRQIDPPSTSSSTNGGKTLPLLLASPGFIAAAFLQYIKDEAIRTTNKPLLSLLPSIIIAHSSSPHIHSLHEVLSSPAMTSKLSDTKFARETALMDKFHALMRLDDGRAWYGPREVERAVAKGAVGRGGGVLLINNVLFRAHNVAERRRWVRLVDQVRDVEGGEVRVLSSLHESGKRLEGLGNIAAILTYPLEDLDDEAGADDGGVGGEEREMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPV9</accession>
    <name>R0IPV9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_88943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025508.1">
        <property type="nucleotide sequence ID" value="XM_008027317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPV9"/>
    <dbReference type="STRING" id="671987.R0IPV9"/>
    <dbReference type="GeneID" id="19405739"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="247"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA86965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="735" mass="81542" checksum="4F9A06D2F611F37E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQ75</accession>
    <name>R0IQ75_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Agmatinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_41375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025116.1">
        <property type="nucleotide sequence ID" value="XM_008026925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQ75"/>
    <dbReference type="STRING" id="671987.R0IQ75"/>
    <dbReference type="GeneID" id="19404693"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_0_1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000001">
        <property type="entry name" value="Agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353223" description="Agmatinase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40251" checksum="427BC12EE0A79A4F" modified="2013-06-26" version="1">MALRSLLSAAPFLALAHTREITFPPVTGYSSQHVMPQDWLDADITHSRFEGLMTFAHFPYVHCLAPKGQHVEPFDIAILGAPFDTGVTARPGARFGPGGIRAGSRRMSPDAGWSIYTGENLLLDWAKIVDCGDAPLTFLDNTVALKQLDQAHQIVSSRETNSTQHKTPKIITLGGDHTTTLSALRSAYHHWGQVSVIHFDSHIDTWDPDVLGGGISHYAGVNHGTFLHIAHEEGLIRNTSMHAGIRAPVARPKGDVRNDIRCGFQMIKARDIDRIGVSGVIEKLKERVGDSKVYISVDIDVLDPAFAPATGTAEVGGWSTRELLSILDGLEGLDVIGADVVEVAPIYDNPGETTVLAAAQVVESLIGLIVKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRK4</accession>
    <name>R0IRK4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_163283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025760.1">
        <property type="nucleotide sequence ID" value="XM_008027569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IRK4"/>
    <dbReference type="STRING" id="671987.R0IRK4"/>
    <dbReference type="GeneID" id="19398724"/>
    <dbReference type="eggNOG" id="KOG3409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_3_0_1"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA87321.1"/>
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    </evidence>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024857.1">
        <property type="nucleotide sequence ID" value="XM_008026666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IS48"/>
    <dbReference type="STRING" id="671987.R0IS48"/>
    <dbReference type="GeneID" id="19395368"/>
    <dbReference type="eggNOG" id="ENOG502S73P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027352_0_0_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049511">
        <property type="entry name" value="PGH-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17660">
        <property type="entry name" value="BTRD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353254" description="Beta-lactamase-related domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="318"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA87655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="645" mass="71283" checksum="8253C6CFE36876D5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0IS81</accession>
    <name>R0IS81_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_39314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024724.1">
        <property type="nucleotide sequence ID" value="XM_008026533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IS81"/>
    <dbReference type="STRING" id="671987.R0IS81"/>
    <dbReference type="GeneID" id="19404462"/>
    <dbReference type="eggNOG" id="ENOG502QSM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044863_3_1_1"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025095442" description="Pectate lyase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA87526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="236" mass="24966" checksum="3ACB2B108B1D138A" modified="2013-06-26" version="1">MKFAEIFTAATALLPATLACNGYTGGVPQAVGTKSNSKVIEVGAGQTYDGQWYRFDRGNGACNGQTEGGASDAVFLLKEGATLRNVIIGKHQSEGVHCQGHCTLEFVWFEDVCEDAISIKQDKPGKQSWIIGGGAYHAADKVVQHNGCGTVNIINFYVNDYGKLYRSCGNCSSQCKRTVYIEGVTAVKGNELAGINSNYGDTATLRNVCSDAKVKCQMYTGCAGGCEPQKAGVCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IT40</accession>
    <name>R0IT40_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_109206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024684.1">
        <property type="nucleotide sequence ID" value="XM_008026493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IT40"/>
    <dbReference type="STRING" id="671987.R0IT40"/>
    <dbReference type="GeneID" id="19395350"/>
    <dbReference type="eggNOG" id="KOG1510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094271_1_1_1"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="81"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA87821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="155" mass="17605" checksum="25B3937C37E3895D" modified="2013-06-26" version="1">MGDILTQIQDELDMLLNQMSAALRQIRDNAPPSVPPGQQRLDTFAELEAREAAQHNATADASQQQFVPPPKPSPEQFQADIKELAQDITLKEQQIEKLIAHLPGLNWSEKEQVERMRELERQLEDLEGVRVKAVKEKDMLMKMVEDKIAGVGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0ITU7</accession>
    <name>R0ITU7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_184057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024157.1">
        <property type="nucleotide sequence ID" value="XM_008025966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ITU7"/>
    <dbReference type="GeneID" id="19402014"/>
    <dbReference type="eggNOG" id="ENOG502TAYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048470_0_0_1"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="480" mass="52762" checksum="1BB34A65835645B5" modified="2013-06-26" version="1">MSNNTDYFTNPKNHPDNAHLPTLNQPATILGITIAFLGVAILTVCLRLWVRLKDRLWGWDDFFVVLAAIASFVGDIMVCRMPKDGLGLHLWTLDWTHLVNYFKHIYSTNAAYAASSTLIKLSILFQYLRLFAETAPSTSTRIYHLSRRLTWGMIAVCSAWGLTFFPLALFSCRPIAKNWDPLVPGKCIGWGSKDPEEFFAMFLGHAVSNSVLDILVLLLPVPFMTALRIAGKSRAGLIGLFIMGSSAVVVAIGRIIALSVNRAGTVPVIDMSFYTPLVYIFAVLEVNFAIITASIPIFWPAIATLASNKIFVVNEVEIRVEDVTRHESFDSNGGISLNDRKSTPSGENKMGVVTRVSDHITRKSGEKLSLSTHDRKPSKGSLSVRSAGLGHTGRSPSNASSIGNSFADFGTRPSQDSLHHLYRTCSRENQSSKSLTREDSDDWFAEMDRANARAQATSAQATSAPTSPLPFENMKPSDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0ITY4</accession>
    <name>R0ITY4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_27710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024067.1">
        <property type="nucleotide sequence ID" value="XM_008025876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ITY4"/>
    <dbReference type="STRING" id="671987.R0ITY4"/>
    <dbReference type="GeneID" id="19403163"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_1"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="300" mass="33987" checksum="D9D9B11E9BC1E690" modified="2013-06-26" version="1">MPELYDHDGKPVQHHMARVNGIRLHYITAGSGPALLLLHGTPKTHYYWYRILPLLTPHFAIVAPDLRCFGATDKPPASEGYDGRTNAKDMIALMDALEYKTFAVHGEDRGATHAFCLAGLYPERVTHLSFCEMLLSAGLTQASFFTRDNIAAQYNQTGVWNWHIPFFWMPHVPEMLIQGKEEEFWTHFMKAECYNPSALDQLAIDEWVRCAKAPGGTRGILESYRSHWANLEIEEEILSKGKLKCKVMTVGALEFFGLRVEQQMKSIAEKGEIAEVFECGHSLAIEQPERLANLLIRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IUD7</accession>
    <name>R0IUD7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_168328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023850.1">
        <property type="nucleotide sequence ID" value="XM_008025659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IUD7"/>
    <dbReference type="STRING" id="671987.R0IUD7"/>
    <dbReference type="GeneID" id="19400504"/>
    <dbReference type="eggNOG" id="KOG0140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_4_1"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000044">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000037">
        <property type="entry name" value="Similar to acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF34">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="157"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="268"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA88420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49567" checksum="613FDA8342BF3CDD" modified="2013-06-26" version="1" fragment="single">MNFSIPDDLKRFLANLDTFIEENIIPLQNKDDNIRFFDHRREHARTDWDNGGLPRKEWEDLLAESRRLADEAGFYRLSLPKQYGGQNSADGRGSNLWMAVIREHLAAKGLGLFNDLQTEHSMVGNFPGVIMLMNFGNEQQKAEFIPLRLQGKFRMTFGLTEPGHGSDATHMATKGRPETRNGVKGWLLNGYKKWQTGMHQATHCSIFARTSGNDGEVKGISCFIVPVGTSGLKAESYEWTLNMPTDHATVSIKDVWVPETAALGPIHNGLGVAQAFVHENRIRQAASSLGAAVYCVQQSVEYANERAPFGTPLSHNQGIQFPLVELATQCEMLRQLIRKTAVEMDSMPHNEIEKKIGDKVSMCNYYANRLCTEAADRAIQVHGGNGYSRHFPFEHIWRHHRRYRITEGSEEIQMRKVAAYLFGFGGRKSLVDATKSESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0IX57</accession>
    <name>R0IX57_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_147798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023167.1">
        <property type="nucleotide sequence ID" value="XM_008024976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IX57"/>
    <dbReference type="STRING" id="671987.R0IX57"/>
    <dbReference type="GeneID" id="19396931"/>
    <dbReference type="eggNOG" id="ENOG502SK8M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026305_3_1_1"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342549" description="DUF7580 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="206"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="582" mass="65007" checksum="985A97B808B918BA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYA6</accession>
    <name>R0IYA6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_45859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022499.1">
        <property type="nucleotide sequence ID" value="XM_008024308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IYA6"/>
    <dbReference type="STRING" id="671987.R0IYA6"/>
    <dbReference type="GeneID" id="19405013"/>
    <dbReference type="eggNOG" id="ENOG502RZPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013481_1_1_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="446" mass="49405" checksum="ABDEAF39CCDEE6F2" modified="2013-06-26" version="1">MALALRLYRYYGAHPSASPPVRPKTVEAKQWDLATTDALGRTISASSTSASSGPRVHSTMDITRGSMSSSSTQSTKDDAAGPPSDPFVLRHGRRYIRSASGYPLPCDLPELHRQNLQTLLATAVFGRALGSTPSQPPRKVLEVACGSGYWSAVCHEWLSGQGYEDVSFTGLDIVPLAGDLQRQGIDWKFVQHDLRKLPLPFDDEEFDIVVMKDLSMVVPLGAPSQRTLDECMRILKSGGTLELWESDHIIRSIMPHPPPPPGKNPQDYACAVSTGTFLISHTTPFMDVQNKYLQDSNAWIQEALGRRKLSPTPCSRMSEMLLQETETLCEVENRRVAIPLGEPRWEREAAGETLKRRGSDAGKLKVGSELVEGSILTKEQAAIRHTALLVVIQLIESLEPLLKEVSGKNQEEWQRYWNSMITDLLEQRGASSGECLEVGVWWCKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYH5</accession>
    <name>R0IYH5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_167576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022742.1">
        <property type="nucleotide sequence ID" value="XM_008024551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IYH5"/>
    <dbReference type="STRING" id="671987.R0IYH5"/>
    <dbReference type="GeneID" id="19400228"/>
    <dbReference type="eggNOG" id="KOG3252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076723_0_1_1"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="46"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA89825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="245" mass="27311" checksum="A06AC507321E4679" modified="2013-06-26" version="1">MGAPFDFAPERPDHMQQILDGLDRYNPETTGVFQDYVMQQCENQTYDCYANLALLKLYQFNPHLARDETITNILVKALTVFPSPDFSLGLSLLPPHVLAPLSSSLHNPAAGDAPLSEAVQKLNELRNLLEGADYATFWSTLDSDDLYADLIADVSGFEELMRVRIAATVSQAVREVDRSILESWLNLSGSEFDHFVGSVCGWNVDGAKVKVPINKDNEAKGTVVRENVKFDQFARVIKRAYEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYH8</accession>
    <name>R0IYH8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_37479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021934.1">
        <property type="nucleotide sequence ID" value="XM_008023743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J107"/>
    <dbReference type="STRING" id="671987.R0J107"/>
    <dbReference type="GeneID" id="19405005"/>
    <dbReference type="eggNOG" id="KOG1374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006073_1_0_1"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000073">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="11">
        <location>
            <begin position="70"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA90461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="803" mass="89952" checksum="ACD5BB4DB5E32FA5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0J138</accession>
    <name>R0J138_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_144619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021434.1">
        <property type="nucleotide sequence ID" value="XM_008023243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J138"/>
    <dbReference type="STRING" id="671987.R0J138"/>
    <dbReference type="GeneID" id="19396774"/>
    <dbReference type="eggNOG" id="ENOG502S3YN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385418_0_0_1"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="668"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="793"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="824" mass="89876" checksum="F037D0C85518605F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1H0</accession>
    <name>R0J1H0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_76071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021375.1">
        <property type="nucleotide sequence ID" value="XM_008023184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J1H0"/>
    <dbReference type="STRING" id="671987.R0J1H0"/>
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    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_15_1"/>
    <dbReference type="OrthoDB" id="3671074at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
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    </dbReference>
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        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17527" checksum="19285737F087C332" modified="2013-06-26" version="1" fragment="single">GQYWESLGQHGLAETAHRKASLLSTEILGPEHLFTLTSMNNLALVLNSQGKWKEAEAINQQTLARYEKVLGTEHPSTLTSMNNLAGVLSSQKKYKEAEEMNWQTLVLREKALGPKHPDTLTSMGNLAWVLSSQNKYKEAEAINRQTLALREKVLGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2D1</accession>
    <name>R0J2D1_EXST2</name>
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        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_158564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA91100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021749.1">
        <property type="nucleotide sequence ID" value="XM_008023558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2D1"/>
    <dbReference type="STRING" id="671987.R0J2D1"/>
    <dbReference type="GeneID" id="19397834"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF156">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51000" checksum="ADE27F5754F2D5F8" modified="2013-06-26" version="1">MECGKDCKFGFIDATIQRRHIPGPWFAAFSSVFLYLICYIGIEGRITRYYHNKFQTRVLRIGPNALSISDGSAIRAIYVSSGGFPKDVRYKNFNLGPIETIFSTIDTSYRDVRAKAVSPLFSPAEIRGESQPEGSIGRHVQEFVTQLKELHHAKIRTDLLDLCAKLSIDVVSNYLLGLPYGGLTEHAHLSLTDRQTDEAKLSANAFVHAIVGFARFSLLPNWIFKNVYSISQRLARDEKVDKSFAKIAEFIDRVMAKTKTSYSAGTLQRKRFLYQDRLLAAGVSFTETAAQSKAILFAGADSTAVALATTLFHLTKNENARHRLLCEVRSATSSNNKEQNELSFLRACIKEGLRLCMANPTRLTRIVPNTATLVVDGFQIPAGSVVGCAASVLHYDPDIFPHPFEFRPERWMKEDSSDGLRRPDMDKNLMAFGQGLRACLGKNLALHQLHLAVAAIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3T3</accession>
    <name>R0J3T3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_53986</name>
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    <organism evidence="2 3">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_559709_0_0_1"/>
    <dbReference type="OrthoDB" id="3679193at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="488" mass="55651" checksum="C36776FDEB06526F" modified="2013-06-26" version="1" fragment="single">PTLSIHEQLDSEKIHILLTYLSLLALSRHPTRPVIELNMKTQLLQLDAFLSGNITEDGEATHWVPESDTMERQQRYVDLCSQIVPNLTAAIRQQSSANLVAEPKNQVQGGNNPENKMFWRIVLAPKVVETFGEWVAESKKRDTSFNPDFDPWVDPTTNKKLIRILNSIVDLQYDFVSWNHSPPEPSFNQLRLPEGIEFQRVMSDPSLIRTYYRLVTPSGKVFSQTTIIPETSIIYTEQEAREMWLAKSRPKYLIPDPLHVTVPGRRKGQTWTNADGRGKTWTRGDEIFTLKILFFVFDQQTNAYINHHAVDAELADNIDLNNEAWVTAYRKKVAQWRSRATREATKVRDHWRDEEKIAIYAWANAYCREHGIDALLIRRLQIGKDMLSAVNSTVPGTRSVESVSAWARRQMNFRPNSPLGRLAAEQKRVADLVGAGVSVPDAERYPDEFIDMSAFAVQAGKSVEKNDDDEEQKSGEKASKSNEGIMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0J561</accession>
    <name>R0J561_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_162576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021007.1">
        <property type="nucleotide sequence ID" value="XM_008022816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J561"/>
    <dbReference type="STRING" id="671987.R0J561"/>
    <dbReference type="GeneID" id="19398442"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_1"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="316"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA92045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="73432" checksum="67D91943A99FA629" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0J616</accession>
    <name>R0J616_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_162767</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021186.1">
        <property type="nucleotide sequence ID" value="XM_008022995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J616"/>
    <dbReference type="STRING" id="671987.R0J616"/>
    <dbReference type="GeneID" id="19398527"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA92355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="486" mass="52567" checksum="69D26C39D9DFB0A5" modified="2013-06-26" version="1">MQGATIQAPGLSTYLKSLKSTPVDASVEHFTALLKRRQIRNSRPCAIATTALLLRVVGEFKGRDAAKLIERIKQVGRRLTSAQPREVVVGNIVRRVLGLVREVVEEHAEGQTPTGSEPGHATPHAHHKNDSLHRPALSSSISTFSPLRHAVAEPMSASGYADNASDASEPSRRPPLLTSHTSYAPASSAPLVHSLFGLFSQPADTPSATSTPTGQASPVGKGSLTALNLERLAGMERSQNLDLKGEVMEGIRELQDELETSDKQIAEVALEHIHANEIILTHTASTTVQKFLLFAARKRKFTVVHAETYPHDHTATHGILLTGKKREANPGDDEEDDKWKPLTDAGIQVYVIPDSHVFAIMSRVNKVILATHTVLANGGLVAAAGAHMIAMAAKEHQTPVVVLSGVYKLSPVYPFDIDELIEHGDAGGVVPFDDGEFVDKVDVANPLYDYVPADLVDLYITNLGGHAPSYLYRIVADHYRSEDITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JH42</accession>
    <name>R0JH42_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrodipicolinate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_157681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031335.1">
        <property type="nucleotide sequence ID" value="XM_008033144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JH42"/>
    <dbReference type="STRING" id="671987.R0JH42"/>
    <dbReference type="GeneID" id="19397750"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA80683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34519" checksum="FB90F89824327F9F" modified="2013-06-26" version="1">MPSANSTPGAANYAFPPGIHVPSLTWFQSSSSQDIDWAVQEQHFEFLVSSGLHGIVIAGTNGEAATLSSTEKRQLVQSARKIAERLGRADLPITIGGVAGCTRDAIQQTVEAKEAGASYYLALVPSYFHFAMGRDAILAYFQELADASPVPIVLYNFPNVVAGLDLDSDMLEILGKHSNIVAVKLTCGGIAKVARISAAFPQSEFVALAGQSDWLVPAMIVNGVGTITGVANLFPKSCLHMYHLYKSGKLAESSALQVKLSVAELGFGKGGINGTKYVVAHKRGYPESSADCRRPYPRFTDDEKRQWIVKQVSGLDELEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0JIG2</accession>
    <name>R0JIG2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_99795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031642.1">
        <property type="nucleotide sequence ID" value="XM_008033451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JIG2"/>
    <dbReference type="STRING" id="671987.R0JIG2"/>
    <dbReference type="GeneID" id="19406452"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_3_2_1"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="105" mass="12171" checksum="3525667D395A3DBE" modified="2013-06-26" version="1">MSAQLFALRWLNPLCCKHPGCEQEHCRTRDPTSNQDGETMAKDPQSAKSIRVHIPLFRRQQNYRASRQEPTWGNSLPICDTTNRKHVVVSWLVRPQRFLGNSLLD</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="EOA81503.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="123" mass="13462" checksum="EC2916313D853EB8" modified="2013-06-26" version="1">MPNSHDSSRAMLASLTGKRTSLRMSTCSAAPTLAPSIAPSHLSDASTANDPKSQDIKTWNAGFDRLEDKRLVQQRYALSSEKNDDMSKLALGAKLDRALGRRMSGQDAVFRPRTLSEKKELKA</sequence>
</entry>
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    <accession>R0JKN2</accession>
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JKN2"/>
    <dbReference type="STRING" id="671987.R0JKN2"/>
    <dbReference type="GeneID" id="19406338"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="358" mass="39545" checksum="8D37480476ACB20D" modified="2013-06-26" version="1">MSRLFQPLKVGPLELGHRIAMAPLTRYRMDDEHRPTLLSKGTANATATIVSRNAIGCRNAPGIWSEEQIEAWKEITATVHAKGCTIYCQLWHQGRTANAQVVQEEGLTMVSASAVPVSPQDQAPVEMTEQTIWTTIQEYATAAKNAIAAGFDGVEIHGANGYLPDQFLQSTCNQRTDGWGGSIEKRARFHVEVTKAVAAAVGAERTAMRLSPYSDFNGMLMDEPEPTFSYVLDALKPLGLGYLHLIEARITGNDDSDCGGQKTVGWMIEQWNNATPVMLAGGFLPDSARQAVDETYKPYDVIIAFGRYFVANPDLVFRVKESVPLTKYDRSVFYTPKTPVGYVDYPHSQQYLQTMAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLV2</accession>
    <name>R0JLV2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_23452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030070.1">
        <property type="nucleotide sequence ID" value="XM_008031879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JLV2"/>
    <dbReference type="GeneID" id="19402675"/>
    <dbReference type="HOGENOM" id="CLU_194742_0_0_1"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9137" checksum="AB25EFD70A3E3018" modified="2013-06-26" version="1">MITDSIRRVNGYDKNAYTYYPVVIVGAGASGIAAACQLKQQLGTDQFRVFDRQAGIGGTWWINRYPGVAWGNTSRETDLRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLZ7</accession>
    <name>R0JLZ7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_97014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030520.1">
        <property type="nucleotide sequence ID" value="XM_008032329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JLZ7"/>
    <dbReference type="STRING" id="671987.R0JLZ7"/>
    <dbReference type="GeneID" id="19406279"/>
    <dbReference type="eggNOG" id="ENOG502SDN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060774_0_0_1"/>
    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="258" mass="28472" checksum="F184F9D5498FCFE6" modified="2013-06-26" version="1">MPPKNALADAWDDDWESLADKDEEKPAEEQPKPKLTKAQLRAQHAEFNKQLWQAAENPEPQWYPQAHPAPVAATFKPKVTMLARKPSPQVLSRTMAGMSLEDDDSEEERKKKAEADFEERKARAQRERAEKERKYAEARERIFGSPAASAAEDSRSNSPNKPTRGKGRGRGGRDSQPRSSNEQSPARAAAPARQLFDPNYTPKPGSAHMQKKESGISRPSTPSTQEKPLRQPQGPARGSGRGFAPRGRHGGAQPGPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0JMK2</accession>
    <name>R0JMK2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_22451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029334.1">
        <property type="nucleotide sequence ID" value="XM_008031143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JMK2"/>
    <dbReference type="GeneID" id="19402554"/>
    <dbReference type="HOGENOM" id="CLU_577668_0_0_1"/>
    <dbReference type="OrthoDB" id="10680560at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
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        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
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    </dbReference>
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        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PSMD12-CSN4_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCI"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA81522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="495" mass="56840" checksum="5F45C4715D2CF1ED" modified="2013-06-26" version="1">MSAGEVLKADKDFTKEADAAIPEAEKLASSNPQAGIDKLLALEKQTRQASDLASTSRVIIAIVTIAKNAKDWNLMNEQVLLLSKKHGQLKQATTKMVQTVMGFLDETPNLETKLSVIETLRTVTEGKIFVEVERARVTRILSNIKKEQGDIDAATDILCELQVETFGSMTRREKTEFILQQVALCIQKGDWTQAGILSRKISTRYFARKPKKTPEQLEKERKEREEAEKNRSVDDPPIEPEDDVTDLKLKYYEQQILLAKHDDKYLDVCKHYRQVLDTEAVEEDPSKLRAILQRVIYFIILAPYDNEQSDLIHRIQRDSRNTLIPQDAQLVKLFTVPELMRWPMVAKQFGPHLTETDVFDAEKGDSDDPKAFQRWQDLRKRVIEHNVRVVAKYYTRIQIPRLTELLDLTEDETEKNISELVSAKTIYAKIDRPARIVTFSRPRDADDVLNEWSSNMKSLLGLLERVDHLITKEEMMARIQPTKVDKSKAIKGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1994020_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="125" mass="13379" checksum="54A784A8F63667C9" modified="2013-06-26" version="1">MRGVVPFQHSTEAGQSSSNRGDSSAAYGVKFLAHADDVSCLDLVGAVRVPAFGPNSLAVVNGPSARDRIYLTDPVKLHTTTRGPQRVHCGPHRLVLGLYPLVQRKGEEKGRRHGTTASVSTNHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0C0</accession>
    <name>R0K0C0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_21822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028716.1">
        <property type="nucleotide sequence ID" value="XM_008030525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0C0"/>
    <dbReference type="GeneID" id="19402486"/>
    <dbReference type="eggNOG" id="ENOG502R79B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103880_0_0_1"/>
    <dbReference type="OrthoDB" id="3786143at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="233" mass="25668" checksum="88A0B640AE3A8C84" modified="2013-06-26" version="1">MADGHGQGLKRPGPTADGGQLPEQANKKIRHAGDSSLATHEAPRALEIPQAIAIARDMGERPFDVGVALGTMLSYIFPLVATHLEHAADFQNSVPEALVWATGFVEAVDGYTAYLRRTDVCADESPSNVAIDCQGRPSLRKYMERYAHVVATAYKDCVRRQLCQVFQSWSRAQTQLFNKGVDKAVSGAQWVVYPRANVVLQAGDNDWAIWLRGLCEELGIMEARAGRRVREDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0R9</accession>
    <name>R0K0R9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_171096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025326.1">
        <property type="nucleotide sequence ID" value="XM_008027135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0R9"/>
    <dbReference type="STRING" id="671987.R0K0R9"/>
    <dbReference type="GeneID" id="19401080"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA86703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="456" mass="51369" checksum="B00411867F8D3642" modified="2013-06-26" version="1">MGCRPLPHVATKWPLGLDLLVRAGRQNKAQTLLQFFLEVIESSGMTHEQRLHFGFGKRTNNFGPLLGSSIFTQDGEAWKHSRALIRPQLAANREQNYEVINNAVEDLIQSIQDNAVVDLQPLFFELSLNTTLYLLFGNTMGQSRNGESAAKDSEFAEAFLVAQEYLSHRGRLGNYYWLANPPKFQRACKITHDFIEQGIRGALDSSNASPQTPAETGEKKARTFIDALLRKTRDHKFIRDQCVSVLLAGRDTTACSLSWMFRLLVRHPQVLEKLRVEIEATIGTGKEAPCPTRTILKRMPYLDAVIKEVLRLYPIAPVNGRTAVRTTTLPVGGGPDGQAPFLVRKGDVVGYFVYAMHRRKDLYGADALEFRPERWEDGTLFRKIGYGYLPFNGGPRVCLGQEYALLMLGYTVTRLIQMFPHMSLPHDEPIEEIDRERQALTLVLAPGDGCRVHVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0K113</accession>
    <name>R0K113_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_115365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025411.1">
        <property type="nucleotide sequence ID" value="XM_008027220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K113"/>
    <dbReference type="STRING" id="671987.R0K113"/>
    <dbReference type="GeneID" id="19395645"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA86828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="510" mass="54882" checksum="B51DA3083B515258" modified="2013-06-26" version="1">MMWVDGKEVQGRAEQLAVEDPATGEIFAHCHAASTTDVDDAVQNAHRVFKSGIWAKAPRHIRADMLDRIAALLTAKLPQLIQLEVHQTGRAIREMNAQVPTLTKWFKYYAALLRTEERSVLPTVGKLHNWVDRKPLGVVAQITPFNHPMLIAVKKIAPALAAGNCIVLKPSELTPLTSIELGKLMKEAGLPDGVFNVLPGDGITTGKALVEHPLIKKVDVTGGTPAGRAIGAIAGRNLAHYTAELGGKAPLIVFEKAQLDLAVNGIAFASFIASGQTCVAATRIIVQNSVLGQVVEKLRGKMQSIKKRMGSPKNVESMMGPLVSAKQLGNVEALVNDAKAAGVTVVTGGERMHGKSSLDATDFSKGYFYPPTILTDSESTKIVDTRIWREEAFGPVIVVVGFDTEEEALRLANDSEFGLGAAIWTQDLPQAFRVSENIESGICWVNTHHRNDPSSPWGGIKSSGVGSENGIDAYNAYTTAKSTIINYASVEEGLASDDWFREGTGEVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1B2</accession>
    <name>R0K1B2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_165644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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    </dbReference>
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    <dbReference type="GeneID" id="19399538"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6612291at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="506" mass="56078" checksum="D62C1D3BD09BA546" modified="2013-06-26" version="1">MVSSTRVYNWYISLVAASCMVLYGYDASVFNALQNSKHWVAYFNNPGPNIIGAINTSYTVGAVAAGFFMGGPLADFAGRRMGMAAGALCVIVATLMQTFAPRGQIGVFIAGRVLIGIGQGLALTAGSIYIGELCPSEIRGKIMSFWQMFYSVGSFIAYWISFGTSKNPKKLGEWDWKIVVIFQMLVPIIILSQVFFIPESPRWYVQKNRNYEQARQSLRRVRDSEEAVEEEITTIREAIEFEAEAISSGYSVLWKDKSIRKRMYIAMIVNGGQQITGQGTLNTYSSIIYKKVFTSADTISLINALNATFSILFTLNATWTVDRFGRKFLFIVGGIGMGLCMLIAATVETQTPTLPNGAKSQSVGISILFLMFLFAFFYKPSWGATVWIFTAEIFSMNVRAQAVGMCSQTQNVVNSIVQQFFPIFLKNEGFYAFYMFAAINVLLAIFTWFFVPETKQVSLEEMDAVFGGKNHVVEGAAIESKDPARQESVVVVGEKGGAAMERVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1C3</accession>
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            <fullName evidence="3">NFACT RNA-binding domain-containing protein</fullName>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
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            <taxon>Exserohilum</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008027310.1"/>
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    <dbReference type="AlphaFoldDB" id="R0K1C3"/>
    <dbReference type="STRING" id="671987.R0K1C3"/>
    <dbReference type="GeneID" id="19398637"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA86958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="213" mass="25094" checksum="A1A86459C02F7A9A" modified="2013-06-26" version="1">MVYYFSSSTVSPAAFIYVGKDKVENEELIKYGWDEDVWFHVDNLSSAHVYVRLPEGEDWEKITNDLLVDCAQLTKANSIEGNKKDNITIVYTPWSNLKKDGSMAVGQVGFKDQRKVKRIHIEKRENAIVNRLNKTKVERFPDLCEEREARRAELRKREQGAMQAKRKEEARIAKERKELAWRRDHAYDDVMTEENLEENSNQNRDENFLDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1M5</accession>
    <name>R0K1M5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_165743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
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            <end position="18"/>
        </location>
    </feature>
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        <location>
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    </feature>
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            <begin position="147"/>
            <end position="341"/>
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    <feature type="domain" description="Chitin-binding type-1" evidence="11">
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    <feature type="domain" description="Chitin-binding type-1" evidence="11">
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    <feature type="disulfide bond" evidence="8">
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            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA83689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="494" mass="51034" checksum="78A60148D90AE441" modified="2013-06-26" version="1">MRLTDVATAALVAPLVAAHGAVPGAPKVFGLPRDLQADFKGPVAARTLRHPAEPRHGLLETRQGGQNGRCGPSFGNAKCAAGYCCSGSGYCGTSKDHCQAPDCLIDFGPACDANKTPGGASTRNDARPQKGNVAYGGAGIYTCQKAGTVAITYDDGPYIYTDRVLDQFASYGFKATFFVTGINLGKGAIDTTAQWSTVIKRMVAEGHQVASHTWSHQDLSVITDAQRYDQMVKNEMAIRNIIGKYPTYMRPPYSSCNAACQTVMKNLGYVISYFDLDTDDYNQLSTIQVAKDNFKRILDATSGGPTSGDRLAIAHDIHEQTALNLTGYMLQYLKSKGYRGVTMGECMGEPEANWYRTSGETVTPPPSNGGGGGNSGTPVSSDGQCGSGKGTCAGSSFGNCCSQYGWCGSTSDHCGTGCNSAFGTCSGTGGGSGGGSGSTPAPGKQVSTDGTCGTQGGATCAGSTFGNCCSQYGWCGSTSGHCGAGCDKTSGTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3S8</accession>
    <name>R0K3S8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_39206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024548.1">
        <property type="nucleotide sequence ID" value="XM_008026357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K3S8"/>
    <dbReference type="GeneID" id="19404451"/>
    <dbReference type="HOGENOM" id="CLU_1907982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="133" mass="15041" checksum="DEA1A059B776775B" modified="2013-06-26" version="1">MDLMPLIFRELHHVEASVNSAPAKRSREVPIRFSVDFSNANKADRMGHAVPCPAKNESDSELSTTSTPFLFVVVRICGVKPASVERYMDSIGLVRLDQKASLGLYPACDVQFQPQRTRQRFQQLDKYLLPPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0K403</accession>
    <name>R0K403_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_21771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028713.1">
        <property type="nucleotide sequence ID" value="XM_008030522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K403"/>
    <dbReference type="GeneID" id="19402483"/>
    <dbReference type="HOGENOM" id="CLU_2051100_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="120" mass="13537" checksum="94538C0CAEBBB4AA" modified="2013-06-26" version="1">MSEEDLVELGRRIQGLKKSGSGLIVVIGMVRTRSNLERDTIPEYVVTAGLFSTGALAVRVWNQDIQMEKLPPWGKKNRRVMDREDFRGLGYQFSPFSSMSNEKLIGYLQGIRIGRSLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4G4</accession>
    <name>R0K4G4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cell division control protein 42 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_164660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028997.1">
        <property type="nucleotide sequence ID" value="XM_008030806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4G4"/>
    <dbReference type="STRING" id="671987.R0K4G4"/>
    <dbReference type="GeneID" id="19399203"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA83222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22147" checksum="8CDD0699FBD2F687" modified="2013-06-26" version="1">MVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQVDLREDSAVKDKLSKQRMAPVKKEDGERMARELGAVKYVECSALTQYKLKDVFDEAIVAALEPPAAKKEGGERKKGKKCCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4J7</accession>
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        <submittedName>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908704">
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2811954_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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    <feature type="chain" id="PRO_5004343815" evidence="1">
        <location>
            <begin position="21"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="64" mass="6817" checksum="2F2225CAD044F1A2" modified="2013-06-26" version="1">MKTTMAILTALAMLTPTVLARCQLQSNDNGVTCPSNKGIFYCDLGSSPKGDCKLIPDTTSWCCS</sequence>
</entry>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027200.1">
        <property type="nucleotide sequence ID" value="XM_008029009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K515"/>
    <dbReference type="STRING" id="671987.R0K515"/>
    <dbReference type="GeneID" id="19398775"/>
    <dbReference type="eggNOG" id="ENOG502SCCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353985" evidence="2">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="247" mass="25033" checksum="78752F681B07AB42" modified="2013-06-26" version="1">MRQSTAILSILASSVSASDVVSFYFPGGYEGLDPVATINTVNPTMTEFRMACPTNVDSADCGWGPGLDATILSQTRYQATMDFESVYMSLGCDYNKKKVEMMCTVSQKGGNDDTGGKAVTASFTGDDVKFLTVTVVAGNTLLSTKASTTPTASATAESVPKSSSIVTSTSSAKSSLATPSRTASATSSSGSSNSSSSSMVFSSSVESTPTPSGSSAAPPESTGAAARYSVGGSALLMLAGAVALNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5N9</accession>
    <name>R0K5N9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_136956</name>
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    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <source>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026948.1">
        <property type="nucleotide sequence ID" value="XM_008028757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7D5"/>
    <dbReference type="STRING" id="671987.R0K7D5"/>
    <dbReference type="GeneID" id="19402375"/>
    <dbReference type="eggNOG" id="ENOG502QTDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_1_1_1"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029039115" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA85444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="292" mass="30773" checksum="895958BB274EB7CC" modified="2013-06-26" version="1">MHYSATLLSTIAAICATANGALTTVTNFGSNPTNLQMNIWVPSTLATNPAIILALHPCGGSGQGYAQSTQYTRLADQKGFIVIFPSTRNDNNCWGVNTAADLSHGQNGDNAGLNNMIQYTIKTYSADANKVFVTGSSSGCMMTNVMMATYPDVVKAGSCYSGVAAGCLAGSPGASPGTADPRCANGQIQKSQADWVAQAKAMYPSWNGPYPRMMTWHGTADNVVRYANLAEQLKQWSGLLGVSFSNNVTNSPQSGYTKMVCGDGTKLVGYSAVNVGHTVPVHADEDLKWFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7L8</accession>
    <name>R0K7L8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_93729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028628.1">
        <property type="nucleotide sequence ID" value="XM_008030437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7L8"/>
    <dbReference type="STRING" id="671987.R0K7L8"/>
    <dbReference type="GeneID" id="19406055"/>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030739_1_1_1"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000006">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA84287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="91117" checksum="2BB5ABC55817A7EC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCQ0</accession>
    <name>R0KCQ0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_101412</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021458.1">
        <property type="nucleotide sequence ID" value="XM_008023267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCQ0"/>
    <dbReference type="STRING" id="671987.R0KCQ0"/>
    <dbReference type="GeneID" id="19394855"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_4_1_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="247"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA90668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="657" mass="72641" checksum="BD22A0D1A1ADDF06" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDL6</accession>
    <name>R0KDL6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_175045</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021670.1">
        <property type="nucleotide sequence ID" value="XM_008023479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDL6"/>
    <dbReference type="STRING" id="671987.R0KDL6"/>
    <dbReference type="GeneID" id="19401371"/>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070156">
        <property type="term" value="P:mitochondrial phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="54"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="341"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="365"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA90988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="500" mass="56075" checksum="5EE3507B414B345B" modified="2013-06-26" version="1">MSDTIRPPGAFPKEITVEGKTYPTDEWMNTPSTILSAIPRRLHLQPDHPLTITRKLIESRFPGYKTHNSLFPIVSTAQNFDSLGFPLDHVGRSRTDTYYVNKSTVLRTHTSAHQSDTFRNNESEGYLISADVYRRDAIDRSHYPVFHQMEGARTWDREQAARQGKTLARVIWEDVEKIPKHDVAVEDPNPTFNAERNPLQQGHSPEEAEAIAAHLKRSLEDMVVTIFNAAKGASGPQSGAEEPLKVRWVEAYFPFTSPSWELEVFWQGDWLEVLGCGIVSQAILDNASVPTRSGWAFGLGLERIAMLLYSIPDIRLFWSKDERFLSQFSEQKPICRFVPFSKYPACFKDVSFWLSSSSNAAGGAAASRQESGAVSSHSPPDTASTQSRLQDGQEQQEQQPTSDTGTPDNAAAPIPPAAAPPTPPSFHENDVMEIAREVCGDLVEDVRLTDTFVHPKTGRRSLCYRVNYRSLERTLTNDETNELHARLRNLLVARLGVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEH8</accession>
    <name>R0KEH8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_109148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024613.1">
        <property type="nucleotide sequence ID" value="XM_008026422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEH8"/>
    <dbReference type="GeneID" id="19395342"/>
    <dbReference type="eggNOG" id="ENOG502T69S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646494_0_0_1"/>
    <dbReference type="OrthoDB" id="3801226at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="470" mass="53104" checksum="2CE20038D2D9DC83" modified="2013-06-26" version="1">MEAPSDLGQLQAPLRHLAAQAQKKRDEVTRLKRQLAQSEKEVLGLDSDYQTRLLCYARAACLELAHRMHQKLPAALRELVYEYLCLDPGRPIPAGPYYHFRSYHVPPVVPPPPEAALDSHAGWRHQTQGTPKPIEHLSGLDVSPDTEDIDLGNDCIVLPDGRIKEEHTHRAPSDMVLPSSPLLDPRYVGPAMSYEMQKMYYTHNTFSLCSVEDGIANFFGHHTGYSMQKWPQGRRPRLAAALELDPLFFAAEHIRRLQIRVKLEHFFSDMPKDATGVEAYAYEQSFLRSAWSNVQGLGHYLARRPKGGAEIEFVLLTGLPCSDSEESRRQCQRCFANFLQCIRSMVYTMMHDCDDVRVTVTHHDDKMSAFPRNITGVFALSREQWEYEKSVQAGGEECEWEACWFAAPARAGVVGLSGIPEDEVHVMLAERWGLESALDARATQAIREGRYWPRARVRDPAAAALLGHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEQ2</accession>
    <name>R0KEQ2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_170296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020608.1">
        <property type="nucleotide sequence ID" value="XM_008022417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEQ2"/>
    <dbReference type="STRING" id="671987.R0KEQ2"/>
    <dbReference type="GeneID" id="19401031"/>
    <dbReference type="eggNOG" id="ENOG502QRSY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034992_1_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="4">
        <location>
            <begin position="111"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone/stilbene synthase C-terminal" evidence="5">
        <location>
            <begin position="226"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA91343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="43552" checksum="2B20D0C119D088B5" modified="2013-06-26" version="1">MKRSAKTDAVYITGLGHEYPPHTIQQEDFAKIIESLYPGHYLSSPGIQKLVDFNTKTQIKCRPTVSDNNTWTQKDAQPPSLTSLSRSFRTKGLDLATAACTKAMSEAGGNPGYDLFVSERLGLGPSVQRVLVQGVGCAGGLSALRAAADIAAAAALKRRCARVLVSACELCSLFFRTELHNIVHTHDQTLHIAPALFSDAAAALVVCNGLALQTHTRPVFQLAEWASSVVPGTSGFMSYHVEKNGMIATISKDVPKAAISAIAPMFQQLCNNTRGRPRKTPDLDWALHPGGAAILHGAKHALHLSDSHIRASLDVYRNHGNSSSASVLIVLDTLRRLGPGRDDVAAVSFGPGLTVEMCIMSRCRGDADSRAATPPGHRGKMASFCGALYSRLSRKVAGRHAAVVKDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KF67</accession>
    <name>R0KF67_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 63 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_87292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025359.1">
        <property type="nucleotide sequence ID" value="XM_008027168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KF67"/>
    <dbReference type="STRING" id="671987.R0KF67"/>
    <dbReference type="GeneID" id="19405639"/>
    <dbReference type="eggNOG" id="ENOG502QVAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026963_3_1_1"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="252" mass="26585" checksum="3E6EBF8DE14DC33D" modified="2013-06-26" version="1">MTPAHVASSPPVASPAADSTAPVASSPPNASSPGTSSPPDTAANGQIFKGDTTWYGESCGEEECWQKGACAFVDYTLPATIDGSTCVSEVIWNSSYHCGACVEITYQGKKKIAMITNKTGGDSVHLDLSPNMFSNLEDKSLGEITTNWQYVACPITTPLEIRMHGGASQWWFAATVVNARLHTAKLEVSSDGGNTWKATTRNVNNFFTFPGSGGTNTPTAWVRVTSDTGSEVVVKDVDLTSNKSTKGASNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFW1</accession>
    <name>R0KFW1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_135482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025524.1">
        <property type="nucleotide sequence ID" value="XM_008027333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFW1"/>
    <dbReference type="STRING" id="671987.R0KFW1"/>
    <dbReference type="GeneID" id="19396313"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019266_0_1_1"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="99"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA86987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="560" mass="61702" checksum="DA28530E2DECA207" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGG9</accession>
    <name>R0KGG9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_148903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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    </evidence>
    <sequence length="76" mass="8679" checksum="02E5A296283476F1" modified="2013-06-26" version="1">MAPTLYPRGTVKKIVKAHSNRQVSKNVDILIYLNYALFMQELINEASIKSKQRGERGVSARSVKRVSEDVLRKYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Salicylate hydroxylase, putative"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
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            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <sequence length="436" mass="47811" checksum="F8A68CB67E03D562" modified="2013-06-26" version="1">MPSAISPSRPFNIAIIGGGISGLSLALTLLDHNIPITIYEAASGFSEIGAGVAFGPNAGRAMEYLSPKILQAFRKCRTGNGDGAKANVWFTVRVGDDRKADKDGFVKKGVKVGDPCFVVPLPEDGERGGVYRAHFLDELVKDVPEDVAKFNKRLVDMEEAADGSGDMVLKFADGSSAQHTAVIGCDGIKSMTRKWVLGRDNPASNAVFSGKYAYRGLIHMDKAVELLGDDVARNGQMFLGYHGHLLTFPIAHGKVMNVVAFRSRETWDNDNWVVTTSKEDMQADFAEWGPHVQKIVAAMEKPDIWALFMHPPCDSFTKGRVVLLGDAAHASTPHQGAGAGMGIEDACVISNLIKDANNTDELMRAFAAYDQVRRGRPQENVARSFESGKLYDFELELEGDDMDKIEHNFVNRMKWVWNFDMNAHLTEAQKIMRQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KL23</accession>
    <name>R0KL23_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_183172</name>
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    <organism evidence="2 3">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022763.1">
        <property type="nucleotide sequence ID" value="XM_008024572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KL23"/>
    <dbReference type="GeneID" id="19401968"/>
    <dbReference type="eggNOG" id="ENOG502RISE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1408625_0_0_1"/>
    <dbReference type="OrthoDB" id="3769880at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354250" evidence="1">
        <location>
            <begin position="26"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="208" mass="21069" checksum="43B883C7271730C0" modified="2013-06-26" version="1">MAQKKSPHLLHMLLHCLPLLALTTASPSPSPNTATNTATNTATCTNILSNPSFESGTLTPWLSLASGSFSTRGISTASPGGHTGSARYTAHCNGSADIQSALAVSQSYLEIAAGATAGCSAWIKSRRASGETRVELFLDAESCAGPVWVGETDGWVRVGGGEGAKKVRVGEGAGEGVGHTVVVSVVGKGVTDGGWSVEIDDVGVEIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0KM33</accession>
    <name>R0KM33_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_183753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023616.1">
        <property type="nucleotide sequence ID" value="XM_008025425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KM33"/>
    <dbReference type="STRING" id="671987.R0KM33"/>
    <dbReference type="GeneID" id="19401992"/>
    <dbReference type="eggNOG" id="KOG0869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_10_0_1"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000110">
        <property type="entry name" value="Nuclear factor Y, subunit B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA88997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="183" mass="20248" checksum="AAA90F17BE27F2A0" modified="2013-06-26" version="1">MSASPPKQEGVEPAQSPDEEQPMDRNTEENTAQIGYEFEVKEQDRWLPIANVARIMKMALPENAKIAKEAKECMQECVSEFISFITSEASEKCQQEKRKTVNGEDILFAMTSLGFENYSEALKIYLSRYRENKPPTGQFAAGPGGPNAGGSENQQHVLNAESEMGDDTTAFGYPVHNGNGAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0KMH3</accession>
    <name>R0KMH3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_146070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022201.1">
        <property type="nucleotide sequence ID" value="XM_008024010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMH3"/>
    <dbReference type="STRING" id="671987.R0KMH3"/>
    <dbReference type="GeneID" id="19396850"/>
    <dbReference type="eggNOG" id="ENOG502QUGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001743_0_0_1"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Han J."/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <sequence length="243" mass="26996" checksum="D97A876F7D7BECAC" modified="2013-06-26" version="1">MATSSNPLGPGPRYGLGRTAPPPQPAAQPGFSSTPAYAPNPKNAQRLEADRLERERTAREAAQRIEASGAASLAELTEEQREEIGEAFNLFDLDKDGYIDYHELKVAMKALGFDLPKQEILAILQQHGSPAPSTQNPKQPSRQQQQQQQYATPGRQLLSFQAFQTLMAQRILSRDPRDEILRAFELFDEGGKGTITLQDLTRVARELGEALSHDELVAMIEEFDMDNDNAISRDEFIQICMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSP4</accession>
    <name>R0KSP4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_133966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020973.1">
        <property type="nucleotide sequence ID" value="XM_008022782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSP4"/>
    <dbReference type="SMR" id="R0KSP4"/>
    <dbReference type="STRING" id="671987.R0KSP4"/>
    <dbReference type="GeneID" id="19396228"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_3_2_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="70064" checksum="9AA565897AF519C4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTX2</accession>
    <name>R0KTX2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_161994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020530.1">
        <property type="nucleotide sequence ID" value="XM_008022339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTX2"/>
    <dbReference type="STRING" id="671987.R0KTX2"/>
    <dbReference type="GeneID" id="19398238"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_9_1_1"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="48"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="313" mass="34911" checksum="76CB010AAB5F1AE2" modified="2013-06-26" version="1">MSLHTTAENRFDGFNIYRTSYKKIGDHKIEVNVLVPKGISPGKHPVMVRWHGGGLTTGTAMYAEWFSAYLVPLIIDNGAIAVLPNYRLTPEHTGDDILEDIASLGDWLTSSLPTYLASKDSSIEPDLSRILMSGDSAGGWMALQSILSLPENTFRACFIQYPVVNAIPISPDAILMGNPVPPKSDLDEFLASMKPGTIISGATPPARATIMSLLLAYGRWDEFFGTGQHLMPETRIETAKFFVPTYIMHGKDDSLVPLKWTEKFVDRARELFPHTRFDLVTPPGEHGFDDSIYKEDHPWLAEMLKSVEKDWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>R0KU62</accession>
    <name>R0KU62_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_86222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020709.1">
        <property type="nucleotide sequence ID" value="XM_008022518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KUU0"/>
    <dbReference type="STRING" id="671987.R0KUU0"/>
    <dbReference type="GeneID" id="19401041"/>
    <dbReference type="eggNOG" id="ENOG502QSGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016116_1_1_1"/>
    <dbReference type="OrthoDB" id="3426327at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF39">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343484" evidence="5">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA91537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="486" mass="54728" checksum="E8D6A5BB2E14B5C3" modified="2013-06-26" version="1">MRLGTLLCQLVLASATTSAKWIVPGARWRATDGSLVNAHAGGVTRDAGTGKFFWFGEYKVQGQEEGGGVSVYSSSDLVTWEPHGLALEPIEGHPHISNEDIIQRPKVVYSEATRQYHMWWHADNRTYGELLQGLAVSDNITGPYTYVDATAPLGNWSQDFGMFVDQKDGRAYAQYSNGDRREGRDVYLTSFNENITALDEVVHRFDKYDLEAPNIVQTDKSYFALMSHKTGYRPNNVVAFRADSLSGPWSQPFIIAPLNTRTFNSQSGFNLRINGTKKTTYIYMGDQWDSNSLWESRYIWLPMEINEEEKSLELVWHDVYDLNVETGEITPIEGTTYYNMEATTTGKAYHQEATFASDKTIVTGIYGNDSKATFHNVEGSGKPQWVSFYYQNTDDMGFGDQPGGTPDRINGTWQLRRISSVIVNNKTEELQTLYQRDTHKGIILSSPLMLNLDKGSHNTITIGGLYNGHDYKGADIDRIVVYPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0KW73</accession>
    <name>R0KW73_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_162536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020976.1">
        <property type="nucleotide sequence ID" value="XM_008022785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KW73"/>
    <dbReference type="STRING" id="671987.R0KW73"/>
    <dbReference type="GeneID" id="19398422"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074611_0_0_1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26672" checksum="3A52F122E7981692" modified="2013-06-26" version="1">MAHVNGNAPKITLYTNHRCPYAHRAHIVVKELGLPYDEVIIDLDKPREQWYLDINPRGLVPTIKFNDEIITESSIVATFLADAYPSHVLPASGSPETALARARINFFIDTWNTKAGSYLFKIMMLDSDEEKAKLSNEFIDVVGKEIDPLLKDAKPFFGGSEKPTLAEAITAPFIIRIYSLSRHGALPQAIASGFDKLPNFSKWAAETIKQESVTYIYDEEDVVKSFVAKINSLKAKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0I4X0</accession>
    <name>R0I4X0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_100357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031349.1">
        <property type="nucleotide sequence ID" value="XM_008033158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I4X0"/>
    <dbReference type="GeneID" id="19394783"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
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        <location>
            <begin position="139"/>
            <end position="157"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
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            <end position="255"/>
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            <end position="296"/>
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            <end position="333"/>
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    </feature>
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    </feature>
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            <end position="386"/>
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        <location>
            <begin position="406"/>
            <end position="426"/>
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    </feature>
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        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
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        <location>
            <begin position="1"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6L6</accession>
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        <recommendedName>
            <fullName evidence="9">Carotenoid oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_99499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
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    </dbReference>
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        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="662"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA81230.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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        <domain>
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    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_008030343.1">
        <property type="nucleotide sequence ID" value="XM_008032152.1"/>
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    <dbReference type="AlphaFoldDB" id="R0I911"/>
    <dbReference type="STRING" id="671987.R0I911"/>
    <dbReference type="GeneID" id="19396639"/>
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    <dbReference type="HOGENOM" id="CLU_005391_4_1_1"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
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        <property type="reaction ID" value="UER00374"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="94"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA81995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="584" mass="63363" checksum="5868F58A855B94D0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9S9</accession>
    <name>R0I9S9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_44009</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030163.1">
        <property type="nucleotide sequence ID" value="XM_008031972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9S9"/>
    <dbReference type="STRING" id="671987.R0I9S9"/>
    <dbReference type="GeneID" id="19404894"/>
    <dbReference type="eggNOG" id="KOG2187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_3_1_1"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000104">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA82096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="570" mass="63002" checksum="AC2C2B90E455E291" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0IA32</accession>
    <name>R0IA32_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_165625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">28A</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="eggNOG" id="ENOG502QTNE">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
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    </reference>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008030632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IE39"/>
    <dbReference type="STRING" id="671987.R0IE39"/>
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    <dbReference type="OrthoDB" id="2139957at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GH43_C2"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_43"/>
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        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342316" evidence="5">
        <location>
            <begin position="20"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="345"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="553" mass="59791" checksum="402C3E47B827CA73" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IE68</accession>
    <name>R0IE68_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_164821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029155.1">
        <property type="nucleotide sequence ID" value="XM_008030964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IE68"/>
    <dbReference type="STRING" id="671987.R0IE68"/>
    <dbReference type="GeneID" id="19399254"/>
    <dbReference type="eggNOG" id="ENOG502S7C5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062856_0_0_1"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="30"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA83441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="307" mass="33917" checksum="829D49A7404AD467" modified="2013-06-26" version="1">MSATQTMMVPHLGGITASYRLSSRFEPSKPTLVLVNSFLTSAALYDSFFANEAVTSRMNLLAIELLGHGQTRAHKVEHWTYWDTAMMNLQVMEALGIQKAFVLGTSQGGWVTVRMALLSPSKILGIMPLGSSLDYESERSRQLGCWEALEPLAAMVTGELSAKNNQPTPDFAPTDAFGNFLVEQGFGPECPADVKDYWIAHLQNTYKGDEGRRRMRMAAICLRDRDGLHLRAADVTCPVLWLHGTKDTVYSVANAQEEIKLFTNSPEARLEIIEGGQHFLNASKPNEVMDKAIAFVTKYAPRAVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IF93</accession>
    <name>R0IF93_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_138651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Barry K.W."/>
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                <person name="Lindquist E.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Schackwitz W."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Tu Z.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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    </evidence>
    <sequence length="288" mass="31103" checksum="EDD738EC37DD3907" modified="2013-06-26" version="1">MSEEVKNASTDVPRSMLLSLVINGTLALGMLFAVLFSAQDISQLLSDESAQTAPFLRIFHQAVGSKAGATVMVAIIVLLEFCSAMGCLAAASRMTWSFARDRGLPFSRALSMIDKRSTIPVMSILAVTLFAALLALINIGSSAAFNGTLSLVLEGFYLSYLLAIGLLFWRRIRGDLDASSSSSSSSSSPFPSLHHEHFHRHADAETRISWGPWRLNAALGVANNAIAICYLLVIIFFSFWPIQTNPGVAGMNWAGVVTGAVALFSVLYYWVFAKRTYTGPVVEVEPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0IG44</accession>
    <name>R0IG44_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_21548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028025.1">
        <property type="nucleotide sequence ID" value="XM_008029834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IG44"/>
    <dbReference type="GeneID" id="19402443"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="122"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA84190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="669" mass="75145" checksum="E8E53952664B40E2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHL1</accession>
    <name>R0IHL1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_29255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908704">
        <property type="protein sequence ID" value="EOA84471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027884.1">
        <property type="nucleotide sequence ID" value="XM_008029693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHL1"/>
    <dbReference type="GeneID" id="19403329"/>
    <dbReference type="HOGENOM" id="CLU_710113_0_0_1"/>
    <dbReference type="OrthoDB" id="3694330at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="389" mass="44176" checksum="C0011351CB696ADE" modified="2013-06-26" version="1">MQSASGISNGNSLPEAPPEPSCHSPIVSQPSKAPQELPESPTPSAPCSSHTSPLERRIATLEREKADLARLVTEAENETAAAKLRAQDRYTEKLHAYNEVRHLQQEIKDRDFRRKDYMIKIEKSFRSLRATIAQLETEKSNRDFGRESKGKIEELEGQLNDMQAGFVSSQEEKAAMKIKFDQTTVDLKKLVLSLKSSLTAEQKRAAAMESRPTAEELQARVDAAKADVVKDMKAKWQSEIEENKANFNQREKELVQSHKTEFKNAKTHWQSRIKALEAEVCARDKKLETAKKELELLRQQLHRAMHNNMQTSDTQQHLPNVFQQASDPNKKRKLDARVLMWDHKIVSATARSASPLVPTKIPGTHAFIRMLSCQRSHRREASSNPWGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0II84</accession>
    <name>R0II84_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_32135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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    <feature type="chain" id="PRO_5004343137" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="EMBL" id="EOA84895.1"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="108" mass="11807" checksum="B558C4650A76B83E" modified="2013-06-26" version="1">MKITPIAIISQLAAITTAVQQDCHSIGYTIDGCGALGGERSTWKCKPTSDDPYLKYGPPNNRCQFMQADYNPNPPHNLLDKIYCVCIPNQEYQYSSGTNNSRSASSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIL4</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_163616</name>
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    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008029136.1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="51"/>
            <end position="69"/>
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            <begin position="194"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="568"/>
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    </feature>
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        <location>
            <begin position="588"/>
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    </feature>
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            <begin position="1"/>
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            <begin position="462"/>
            <end position="486"/>
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        <location>
            <begin position="1"/>
            <end position="14"/>
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    </feature>
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        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84776.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="614" mass="66986" checksum="2A363C84235CB0E7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJS7</accession>
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            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="21" type="ORF">SETTUDRAFT_91465</name>
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027590.1">
        <property type="nucleotide sequence ID" value="XM_008029399.1"/>
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</entry>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908648">
        <property type="protein sequence ID" value="EOA85711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026658.1">
        <property type="nucleotide sequence ID" value="XM_008028467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILN0"/>
    <dbReference type="STRING" id="671987.R0ILN0"/>
    <dbReference type="GeneID" id="19398200"/>
    <dbReference type="eggNOG" id="KOG4266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003559_3_1_1"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1710">
        <property type="entry name" value="Subtilisin-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343617" description="Subtilisin" evidence="8">
        <location>
            <begin position="18"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="114"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="10">
        <location>
            <begin position="587"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA85711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="89231" checksum="9C9A3B5018548FE7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0IN19</accession>
    <name>R0IN19_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_169187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026029.1">
        <property type="nucleotide sequence ID" value="XM_008027838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IN19"/>
    <dbReference type="STRING" id="671987.R0IN19"/>
    <dbReference type="GeneID" id="19400820"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="218"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA86420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="32802" checksum="383AC01A98E76C8C" modified="2013-06-26" version="1">MAAVAPAATAQQVVVTKPQGFDLYSRFALAGAMGCSITHGAFTPVDVVKTRIQLDPATYNRGMIGGFRQVIQNEGVGALATGFGPTCAGYFMQGAFKFGGYEFFKQKSIDVLGLEKARENRALVYSVSAGCAEFFASVALCPLEATRIRLVSTPGFANGLVGGFGKILKNEGVGAFYSGFGPILFKQVPYTITKFVAFEKIAETIFDMFDKKSMSSGAQTTVNLGSGLLAGFAAAIVSQPADTMLSKINKTKGLPGESTASRLIKIAGELGLRGSFAGLPTRLFMVGGLTAGQFAIYGDIKKALGASAGVEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0INB9</accession>
    <name>R0INB9_EXST2</name>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA86930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19405695"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
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    </dbReference>
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        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002070">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="251"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="446" mass="49841" checksum="2E62447525D87D03" modified="2013-06-26" version="1">MASAGRRTHYEPPWGNASIIGVAGSSGSGKTSLAMAIVASLNLPWVVILSMDSFYKPLTPQQSAAAFRNEFDFDSPNAIDFDILVDRLKDIKNGKVAEVPIYSFQKHARLPKTTTIYSPHVIILEGIFALHDPRVLELLDLKIFAEADADLCLSRRLVRDVKERGRDIEGCIKQWFSFVKPNYYKYVAPQREIADLIVPRGIENKVAITMVSNQVRQTLQSKSVQHQTELRRLGKIAEDRPLSENAIVLKQTNQVRGMHTLLLNPETSREDFVFYFDRMVALLVETAADFLPFVSYEVTTPQNTTYKGLKKNADVSAVVVLRGGSAFETGLRRTIPDCRTGRLLIQTNYRTGEPELHFRALSTDIAEHGLVLVLDPQFSTGAAALMAVRVLVDHGVPEHKIVFVTYTAGKVGLNRVLSVFPDIRIVVARLGTDEEARWVETKYLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQ68</accession>
    <name>R0IQ68_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_163003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025439.1">
        <property type="nucleotide sequence ID" value="XM_008027248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQ68"/>
    <dbReference type="STRING" id="671987.R0IQ68"/>
    <dbReference type="GeneID" id="19398615"/>
    <dbReference type="eggNOG" id="ENOG502R4J4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014699_0_0_1"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="255"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="655" mass="73509" checksum="8DD4F8A69CFE4BA6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQJ7</accession>
    <name>R0IQJ7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_88939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
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        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
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        <location>
            <begin position="254"/>
            <end position="352"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA89136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="358" mass="39612" checksum="7095B22F34C168C0" modified="2013-06-26" version="1" fragment="single">MAMRALPLRAANALAMPARPAIRPAAAMAVAVCRRHGSSPASSDAVRDLEDASSLQVPPPPRELAASFDPVATSRLRRRGHKQLPPSRYQYRSPKYYRGPLHPHQPPPESDPASRLFQPGPFSLTRLEQTYQSTIAADLLTLTYQHYPPGYRAPTTDQRLREWTGDSPYFKNRPLRPPRGKGEVLRLLQEPRTFRNVPALTKVIVHSMVPDAQENSGHLHVAGMVLQAISNVRAVSHKARHNVVGWGLRKGRYVAVTSTMDRAHADDFLAKLINVVLPRIKEWKGVPGSSGDGHGNFSFGLTPDQVSLFPEIEVNYDAYPPKMIPGCHITIQTDATSNKDARLLLQAIGIPFHGKLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXY1</accession>
    <name>R0IXY1_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_37942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IXY1"/>
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    <dbReference type="HOGENOM" id="CLU_2135086_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="113" mass="12180" checksum="60D75115A8B7F24B" modified="2013-06-26" version="1">MHDQGPRTLKPPRRRRKKTPRPTTVPSRLVPTHPDPPALTSHDEPGPGGCCTRGFKRTSPALPAASALFASLLDPQPTYIQGKEHGASGTRGCSTRDGGKRRYRSDAACQLGK</sequence>
</entry>
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    <accession>R0IYH1</accession>
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        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_103819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022738.1">
        <property type="nucleotide sequence ID" value="XM_008024547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IYH1"/>
    <dbReference type="STRING" id="671987.R0IYH1"/>
    <dbReference type="GeneID" id="19395010"/>
    <dbReference type="HOGENOM" id="CLU_086448_1_0_1"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="282" mass="31691" checksum="E376E20B248ADF41" modified="2013-06-26" version="1">MLNPSSTGNKVLCFKIPNVNRRFTVHQDLICQTSNYFKRRLQRHRRPIFPADECCICTEPFNPTLQDLTFCTHCGQNMHEHCIDAWERVPRNVVSGSKCPMCRARWKSPRHLSCVNIETELDVEAVQSYLDCMYTGTLKEVSASIPRNSDQFSLVMLKRWAVASALEDAAFKAQVLTALFANGRVVIGIESVKWAFVERKCSDEIREFMVDVSLTGIESGWFKEMGKRFPEAFVSQSADGAVRKWRNGNNRRGLGDVRRDWMRRVGAGGGEGSGGGEGGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZ54</accession>
    <name>R0IZ54_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_102391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <begin position="166"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="413" mass="46029" checksum="2EE394CB5CD753AF" modified="2013-06-26" version="1">MWRTGLLYLDRGDSSILNALRNAGYDTQQQQQQQPPPSSPSRTPSRRFSMASDTESALESKLKHEMRAQQGVQHWVMPADVNGLKFVASSPRASPRTRALDPADALGLATDATLFEEPLLYSLDRIKEDRPPPEYFPYDQLQKSPDLKDDSDEPVAVHKRRPSHLRSPSTPTLESRLATTQRSRTQPIRTKTNEGLLQLQANTTKPQRSANTHQRRISLGLPIKTANSPSDNPRHHHLQSPTNTRSLLPATPKRLTKKTPAATAIQQERDLEYKHRHTFIGTASLDDFLEVLDVSPEHTTNKDAIIRAFILLASSERLLARQASLKPDGWSVIARTSADTVNSDYVEQAHAKLGSIVLRQFLDLITFNEDEEANAMSVVEAFTAASHLDAQASKATGSKAKAFRKWMVKAQSA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="167"/>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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    </evidence>
    <sequence length="507" mass="55860" checksum="2CD719FE856CE641" modified="2013-06-26" version="1">MSTRYEDEKISAHDATAQLSEHRTKPGGIAANLSPEKRMQVEKSLKRKLDARCSLFVLIYIMNYLDRNNIAAARLGGLEEDLGLSPTQYSTCLSILYVGYILMQVPSNMIINVISRPSIYIAAVMLLWGMISTLSGNVNSFGGMVAIRFCIGFVEAAFLPGALLILSKWYTRRELALRNAILFCGNLISNAFSSLVGAAVLGNMEGTLGHEAWRWLYWVEGAATMAIAIAAAFILPDLPHNTRGFTEEERAVAVLRMTEDVGEADKDSEEQSAFAGLFMAVKDVKIYVLSITFIAYVLGLSFNSYFPSLTKTLNFGKTETLLLSAPPWILSCFVSLVNAWHSDRQQERCWHIIGPVLVGIVGFIISMATSNTAARYVALFLQSSSYAGFIVVYSWISSSFPRPPAKRAVAIAMINALSQIGNICGSYVWNMTDNGYRNSYGVVTAMFGVTIIGCLIFRAMLIRLNKRLDEGIDTWVVHGDVAEQTAATEGVNLEEGMKIMAGYRYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0J367</accession>
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            <fullName evidence="6">Amidase family protein</fullName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0J387</accession>
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        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
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    </protein>
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        <name evidence="13" type="ORF">SETTUDRAFT_29742</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
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    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">28A</strain>
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        <subcellularLocation>
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        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_29794</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020154.1">
        <property type="nucleotide sequence ID" value="XM_008021963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3C9"/>
    <dbReference type="STRING" id="671987.R0J3C9"/>
    <dbReference type="GeneID" id="19403362"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671148_0_0_1"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005145238" description="Peptide hydrolase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="141"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA91236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="410" mass="44120" checksum="9CFE3E8FBF91EA90" modified="2013-06-26" version="1">MWSASIVAVCAASLLQSAVSTPIHRHYPHQFPSPEIWPAPAVGKALEPQMPGEDLQAIIAQISRDNIEATIRKLASFGTRHTLSSQTDPNRGIGAARTWLTARFQEAAAASEGRMTVDWNSFIKYPGDNARILFPVNITTVVATLKGSEDPDRYYITGGHYDSRNSDPVDYQGDAPGAVDDASGVAVSLELARIFAHYKPKSTIVFTAFAGEEQGLLGAENLAQTYKNASTNVAGMINLDMVVPGGVSRVNDMGPVRRNRLAVHDFVALDGQPRGRGPCELAEVVRPSRVDADLGRDPRGIGKTPHGARDYLCGARVVLKVEPFDHVAVLLAVAYSHVLVLLRVVFVGLHEAHARVSGLEERAVVAAAPVAVEPVDEAHRHLGPRVGRHFVDVAAQVARWAVVFPADAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3Y1</accession>
    <name>R0J3Y1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_86113</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020443.1">
        <property type="nucleotide sequence ID" value="XM_008022252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3Y1"/>
    <dbReference type="STRING" id="671987.R0J3Y1"/>
    <dbReference type="GeneID" id="19405565"/>
    <dbReference type="eggNOG" id="KOG2254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005482_2_1_1"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="10">
        <location>
            <begin position="74"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="11">
        <location>
            <begin position="410"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17652"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
            <begin position="188"/>
            <end position="207"/>
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        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91660.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="207" mass="23238" checksum="D4BFB224EC55405D" modified="2013-06-26" version="1">MDPMFNKHHTEQPANTSPRQNTTTPSTSPAPGSSSSSARQNTPAPSTNPDISQLVAQLIRHVLQKDALLLPIDPTTNPITSTHIDNIAYAMWNTAFQHGALLDRACQYGSMFSPLKLAALARLNFLPSWWFFRSFAVGYLQNMGIDWIVDDADMIITWESAVRGCVEVFGIREARAMEEARVREEARLREEARSEEKAKAMEDEMEE</sequence>
</entry>
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            <fullName evidence="2">mRNA stability protein</fullName>
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    </protein>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="function">
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        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA92201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle involved in cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:regulation of mitotic cytokinesis, division site positioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
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        <location>
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            <end position="148"/>
        </location>
    </feature>
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        </location>
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            <end position="106"/>
        </location>
    </feature>
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        <location>
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            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA92201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="148" mass="16146" checksum="6B2F2AB2B29EFDBF" modified="2013-06-26" version="1">MNPHQQNKVDVSKLSEQEAKLFRLYGKLPNKKDLLQNKLKERKYFDSGDYALSKAGKAGDVGVTQVGREHPNPEKIPHIAPSTPISQTVTVNANGSNGATTSQGDMATSPVKEHTFLHRETSLNRETSASEFENNDMAEDAQGGPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0J6F4</accession>
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    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
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    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Sedolisin_dom"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S8"/>
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    </dbReference>
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        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SEDOLISIN"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 16" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0843">Virulence</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353373" description="tripeptidyl-peptidase II" evidence="17">
        <location>
            <begin position="20"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="18">
        <location>
            <begin position="208"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EOA92276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="573" mass="62787" checksum="FF48C74D9AD3A2C0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0JIJ1</accession>
    <name>R0JIJ1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_36012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031273.1">
        <property type="nucleotide sequence ID" value="XM_008033082.1"/>
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    <dbReference type="AlphaFoldDB" id="R0JIJ1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="53"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="658" mass="74797" checksum="BA5A8E9EE95A27F5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0JKD1</accession>
    <name>R0JKD1_EXST2</name>
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        <recommendedName>
            <fullName evidence="14">GTP-binding protein ypt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_166120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JKD1"/>
    <dbReference type="STRING" id="671987.R0JKD1"/>
    <dbReference type="GeneID" id="19399703"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA81753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23805" checksum="9F5FC6985A60F38F" modified="2013-06-26" version="1">MQQGQRPGGSRFAQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTIALDENTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQAASLDKAKAWVKELQRQANENIIIALAGNKLDLVTESPDKRAISTADAEQYAREAGLLFFETSAKTSENVKELFTAIAKKLPIDQAGPRNLRPGQQRPGVNLRPEANQTQGPAGCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0JL86</accession>
    <name>R0JL86_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_98045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0JL86"/>
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    <dbReference type="eggNOG" id="ENOG502SQYS">
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    </dbReference>
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    <dbReference type="OrthoDB" id="194358at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bZIP_YAP"/>
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        <property type="entry name" value="bZIP_sf"/>
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        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
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        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
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        </location>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="241" mass="26707" checksum="76F8FB717D93DCF4" modified="2013-06-26" version="1">MHRHSAYPYPTTASATTSTRYSGTSSAFSASANPNEDWTKISDLAERRRIQNRIAQRNYRKKLKKRLEDLERRAASSSASPEQKPAELQPPQPSPPRQEFPSPSSSESSYTTPPAEDRMFSHQYTRQLSTSPPPFSVAYSSSYPAPDAVAYSMPYSASPYHTIPTTLATDMPSYAYLPPPHSSSYSTPLPSLVPGMKQDYYSEEDMSPFGVGYAAIGGIEIPPPHSYAHSVRLPARQPYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0JMH3</accession>
    <name>R0JMH3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_22429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029331.1">
        <property type="nucleotide sequence ID" value="XM_008031140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JMH3"/>
    <dbReference type="GeneID" id="19402551"/>
    <dbReference type="eggNOG" id="ENOG502RFPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949973_0_0_1"/>
    <dbReference type="OrthoDB" id="3681251at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="292" mass="32901" checksum="947AD787D5C85B57" modified="2013-06-26" version="1">MAEQKNTYLEALLMLSNNERFSDARRSLPQSMGDEALEKLVADIIHREFTRRGLEDVASTLLDAIARDGETASEDGGGALDTRQKSSSGTQTRLKRDCLRPLDPPEVSVTRKRTAEAASDTAGQKRVKYTLRSHTAKEVKPSLRIQTPQLIQGKLAPAIGVVYWNPVQHRFSPLAFDDERGDSLATRMTKNFDADYLSTYNHVYEWGKLLRLQEKGVASQCCANKTIINRSKYPGTREMGDMTTACDACIRQKQLCARLVKVEMVNKFAFFPLPSALRVGRQLQEIEFWVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNI7</accession>
    <name>R0JNI7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_121241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029794.1">
        <property type="nucleotide sequence ID" value="XM_008031603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNI7"/>
    <dbReference type="STRING" id="671987.R0JNI7"/>
    <dbReference type="GeneID" id="19395843"/>
    <dbReference type="eggNOG" id="ENOG502QQD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_3_1_1"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008823">
        <property type="entry name" value="PRK11873.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA82778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="293" mass="30948" checksum="1870DEAC20224CD0" modified="2013-06-26" version="1">MASSDITSAVHTHYSTLASTTTSASSKSYSTAVASAFGYTPSDLAAIPAESNLGLSCGNPTALANLRQGETIVDLGCGAGFDVFLAARKVGESGRAIGVDFSEEMLARAKRNLENSDAKNISFIKSPITAIPIESGTADVVISNCVINLVPHGQKALVFYEMARILKPGGRVAVSDILAKKPLPEDLQKDMATYVGCISGASLVGEYEEWLKSAGFREVSIVDAGTDVNVYRDAEGSECCTSDVTNAKCSKEEEQVGCCGGQKAKDEIPQKELLAKDVNFNEWVGSFKILAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JQG7</accession>
    <name>R0JQG7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_139949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029135.1">
        <property type="nucleotide sequence ID" value="XM_008030944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQG7"/>
    <dbReference type="STRING" id="671987.R0JQG7"/>
    <dbReference type="GeneID" id="19396528"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_1_1_1"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="292"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA83418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="516" mass="57829" checksum="B242D1506E61C60F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0JR40</accession>
    <name>R0JR40_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Crh-like protein</fullName>
            <ecNumber evidence="17">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SETTUDRAFT_120473</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="17"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029261.1">
        <property type="nucleotide sequence ID" value="XM_008031070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JR40"/>
    <dbReference type="STRING" id="671987.R0JR40"/>
    <dbReference type="GeneID" id="19395818"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_2_0_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353646" description="Crh-like protein" evidence="21">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="22">
        <location>
            <begin position="30"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="344"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="28"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EOA83588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="443" mass="47081" checksum="05EA45725E8CE70B" modified="2013-06-26" version="1">MRSTVRALAALASAALYVPSVAQTWSNCNPILRTNCPPDSALGKTVNIDFSSESSSFTPQGNPTYGSDGVSFTIAKSGDSPQLTSLWYIMFGRVDIEVRAAPGAGIVSSFVLQSDTLDEIDWEWLGADPDEVQTNYFGKGQTTDYNRGAFHSDPGSQTQFKKYTIEWTPEQIVWQIDGVTVRTLEPANANNQYPQTPMQVKFGAWSGGDPSNSAGTISWARGPTDYSKGPFTMKVKSLRVQDYSTGKQYVYGDQSGTWKSIRSVGGTIFAGGNAPIADAPAITATANGAPLPFTPHQTSNYQRPSVYPWIPDPSATPTAQPTFANYPGLPSGWTVSDSGKVIPPSSATMSPLASSTSSPQASLTASSGDGPKTEFSSDDHSFSTIHTTRAPLTTSPTRTRVQGNAATSIPIAPAAASLSWKLIVSSILPWTILALHIPGCLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0JRG6</accession>
    <name>R0JRG6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_92705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028217.1">
        <property type="nucleotide sequence ID" value="XM_008030026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JRG6"/>
    <dbReference type="STRING" id="671987.R0JRG6"/>
    <dbReference type="GeneID" id="19405989"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_14_1"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA83703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="457" mass="50559" checksum="32BC0EEC16547AE1" modified="2013-06-26" version="1">MSSNKKSTLTGYLPDILMAAAAPLIAYFVIRNLLTRLDPDAQQKEEARAKASAATRKLDAILTSKRRKSYSEYDSDDETDARHRRPRIQDLNLNTYEQTIAMEVVAPEEIPVSFEDIGGLDSIIEELKESVIYPLTMPHLYAHSSSLLSAPSGVLLYGPPGCGKTMLAKALAHESGACFINLHISTLTEKWYGDSNKLVNAVFSLARKLQPSIVFIDEIDAVLGQRRSGEHEASGMVKAEFMTHWDGLASSTASGTSEPQRICILGATNRIQDIDEAILRRMPKKFPVALPSATQRHNIFSLILRGTKIDPQNFDLDYLVRVSAGMSGSDIKEACRDAAMGPVREYIRRKKADGTLRSNKAVAQGDVRGLRTEDFFGRGRGLRDLDTLEETREEMNARVRSRVHTTSEESEDATTTTESDDTQSLSRSGYDENTFHDSAYHGAPGTTNNERDAVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0JU26</accession>
    <name>R0JU26_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_116640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027163.1">
        <property type="nucleotide sequence ID" value="XM_008028972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JU26"/>
    <dbReference type="GeneID" id="19395693"/>
    <dbReference type="eggNOG" id="ENOG502RH0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023528_0_0_1"/>
    <dbReference type="OrthoDB" id="2580323at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343647" evidence="1">
        <location>
            <begin position="21"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="551" mass="61326" checksum="D7A4562E2B9B4879" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0JU94</accession>
    <name>R0JU94_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_166448</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031619.1">
        <property type="nucleotide sequence ID" value="XM_008033428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JU94"/>
    <dbReference type="STRING" id="671987.R0JU94"/>
    <dbReference type="MEROPS" id="M01.007"/>
    <dbReference type="GeneID" id="19399815"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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            <position position="324"/>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81819.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18736" checksum="82A3493D82190C04" modified="2013-06-26" version="1">MSAPRSKEHLRLALEIRRNGLPAPVPCDYCFANNRQCVAMPEVNSKRLKCSECTRLGHPCVNMSWVSLDKTREEYQKKVDEDEQLLAQVISRLMRNKRILKQAEERAAKKTMCLANSLRAGGDDVDAQESLDCPAADALVGFSPVMWSTLGSLDALASPSNPGDAPVFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWZ4</accession>
    <name>R0JWZ4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_164097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027841.1">
        <property type="nucleotide sequence ID" value="XM_008029650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWZ4"/>
    <dbReference type="STRING" id="671987.R0JWZ4"/>
    <dbReference type="GeneID" id="19398996"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021251_2_0_1"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000133">
        <property type="entry name" value="Protein serine/threonine phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="94"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA85463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="608" mass="65968" checksum="49C173D8B63EE09C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0JX74</accession>
    <name>R0JX74_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_165570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030400.1">
        <property type="nucleotide sequence ID" value="XM_008032209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JX74"/>
    <dbReference type="STRING" id="671987.R0JX74"/>
    <dbReference type="GeneID" id="19399515"/>
    <dbReference type="eggNOG" id="KOG3229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_0_2_1"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="227" mass="25888" checksum="BB026D6B9F702022" modified="2013-06-26" version="1">METIKGLLWKPTPEEQKRKCNTLVRQNVRKLDRDIQQLKVTEQKTKNLIQQSSKRAQRNPSMAKQANQDVRIFARELIRVRKQSNRLMTSKAQLNSVQMQVNEAFSVRKIEGSIKASTGIMKDVNSLVRLPELTGTMRELSSELMKAGIIEEMLDDTLGENEMLEGEADEAEEEVDKVLSEVLKDRLPPSKAQEQELPAAPQAEEEEEEDQAEMLAQMRGRLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXG4</accession>
    <name>R0JXG4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_24474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXG4"/>
    <dbReference type="STRING" id="671987.R0JXG4"/>
    <dbReference type="GeneID" id="19402787"/>
    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_0_0_1"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="4">
        <location>
            <begin position="131"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA80962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35941" checksum="9FC8E791AEC8A679" modified="2013-06-26" version="1">MSATVEIKSPAQLSSLLSSSRVVVVNFYNEENTSSKAIAPVYDQLAGQLSRPGKVTFSKVSTVQQAQIAQSYNVTNTPTFIIYKNNQQIRKYSGSNPQQLSEAIKTLAAEAENEGNGLDSASGSSGSGAWTGASLPRGYTDVTDVVDVRGLDLLNADSDFGTVRTLLETSAPSSLSKGKAAQGKKDWVESDVDNQLMLFVPFTATIKLHTIHLTSYISPDNAEDDDEAPVRPKTIHVWTNRQHNLGFEEADDVPATQVIELKPEDWDPTTHTAKLELRFVKFQNVASVVLFVADADGDSEKTRIDRIRFIGETGEKREMGKLEKIGQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXK9</accession>
    <name>R0JXK9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylulose kinase</fullName>
            <ecNumber evidence="7">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_169655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="7"/>
    <dbReference type="EMBL" id="KB908659">
        <property type="protein sequence ID" value="EOA85633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026716.1">
        <property type="nucleotide sequence ID" value="XM_008028525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXK9"/>
    <dbReference type="STRING" id="671987.R0JXK9"/>
    <dbReference type="GeneID" id="19400979"/>
    <dbReference type="eggNOG" id="KOG2531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016149_5_0_1"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="9">
        <location>
            <begin position="140"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="10">
        <location>
            <begin position="306"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA85633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="604" mass="65706" checksum="726DB49AEDB03E28" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0JY53</accession>
    <name>R0JY53_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_70801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
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                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027969.1">
        <property type="nucleotide sequence ID" value="XM_008029778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K240"/>
    <dbReference type="STRING" id="671987.R0K240"/>
    <dbReference type="GeneID" id="19402387"/>
    <dbReference type="eggNOG" id="ENOG502QXTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_4_1_1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="266" mass="30114" checksum="93E4C34EB41EDC6F" modified="2013-06-26" version="1">MGPTPATIYFGVPDLSCTPERRAILTVPPEEHFPAEILLHDFSTSSELTKGVDGLDVQGFTYLKHHSKIQALGNSWDDAQLNQYHPELEALMCEWLGARKAFVINTVVRRVSTRSDPRDWVDRDSNVGKDQESRRHDRILVAGSQGKADMGPVAKAHTDLTLRGMRNTVRFARKDIAEWAQDILRAEDAGRPAPRYAVYSVWRPLGTVERDPMTVCDYRTVDPDGLIPVPIRFPSELVGEFTAYSANLRRPANDKTNMQKWFWLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2F6</accession>
    <name>R0K2F6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_171506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025762.1">
        <property type="nucleotide sequence ID" value="XM_008027571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2F6"/>
    <dbReference type="STRING" id="671987.R0K2F6"/>
    <dbReference type="GeneID" id="19401106"/>
    <dbReference type="eggNOG" id="ENOG502T2QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1695309_0_0_1"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="152" mass="16684" checksum="54173E39E218517A" modified="2013-06-26" version="1">MSDTPIPITTQQAQSGISRDLRNNIYSALLSGPGIRNIEATLDESLRSSGFKDALRAYITELFRSGQATTCEEARNLAMQRIREQTRDLDSKRRTNALADDAANGLANGTAPDTEDALDFDLKIPKSAIDAGAKTVMKELEKVCEITYEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2L0</accession>
    <name>R0K2L0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_138528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028330.1">
        <property type="nucleotide sequence ID" value="XM_008030139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2L0"/>
    <dbReference type="STRING" id="671987.R0K2L0"/>
    <dbReference type="GeneID" id="19396465"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_5_0_1"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA83859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="505" mass="55557" checksum="E70F676EB4729800" modified="2013-06-26" version="1" fragment="single">MASNNQAGRPARPDPFLDDLDAINHHLATPGFLRRLTASQLPSAAVSESSSLSPTREEARLRPPPSNLNLTVTLDDEIEHVDLIAPLIQEPCADGSPGSVEPHVVHHLESAFVAARCAYQTMAAERSFQTFSHGHQDLVLAVDFNYFGTRMVTASSDHRLKVWDKKDDAWTLVESWKAHDAEIVDVKWNGPFMGEVVGSIGEDGRCKLWQEDVTEVAMSGNRFKLLYNLASLTNAPFMSLDFKNIMQETWLALITRDGYLTVYEPQDQSNLHEWTILAERWVSENNPPERQEEVGFKVVFHKEKLPCWTAITAGLDRKSLSLAVAAMKDVLIFRTDKAKRFFQVAKLTGARQVIRDLAWASGSMRGYDILATASKDGAIRIYELTTVTADKASASGASSSAVAPSVSSRPNLKHNAQSGIGAGLAGASKAPGMSLENEQHPGRINQEVALKDELTGHHGAVWRLAFSQMGDLLVSTGDDASIRTWKQAANGHWMEYAQIETAQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2P1</accession>
    <name>R0K2P1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_171567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025819.1">
        <property type="nucleotide sequence ID" value="XM_008027628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2P1"/>
    <dbReference type="STRING" id="671987.R0K2P1"/>
    <dbReference type="GeneID" id="19401112"/>
    <dbReference type="eggNOG" id="KOG3067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079179_0_0_1"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990605">
        <property type="term" value="F:GU repeat RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035939">
        <property type="term" value="F:microsatellite binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA87408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27834" checksum="9AD160802162C3BD" modified="2013-06-26" version="1">MVAQSGMVDPAIFQDLQARIDEDAAVRDELRDIIQALEKHNRNVSFVLSRAHSTRVDELSEMLKAAQEPIDNVIETVSKLSQAASKMPYYKFNNMWSRQMQGACESILFWGWLGGYKYEGGRVQCGRLLTVEELGEIFKIPVNLKERDEFHLSLEEYLHSLMTLVEELTRLARNAVTLGDYERPLLINQFVKDLHAGFQVLNLKNDSLRRRSDGLKYRVKDVEDVVYDLSLRNLVPKKGEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3M4</accession>
    <name>R0K3M4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_156631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029953.1">
        <property type="nucleotide sequence ID" value="XM_008031762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K3M4"/>
    <dbReference type="STRING" id="671987.R0K3M4"/>
    <dbReference type="GeneID" id="19397644"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="94"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA82977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="448" mass="50996" checksum="48EFFCA868AE1A47" modified="2013-06-26" version="1">MASRWANDEADKAEELRRKKEKEEKKRLKLQKQQEAEAAARAAQETESRPAKRRRLSAGEDDEADAKPREAQEERKLLRFEGGGWTSCRHTSNFETLNQIEEGSYGWVSRARDITSDTVVALKKVKMDYNQDGFPITALREISILQRCRHANIVNLHEILAGDDPQECVLVMEFLEHDLKTLQEDMSEPFMASEVKTLLRQLVSGVGYLHENFIMHRDLKTSNILLNNRGQLKIADFGMARYVPPSNAPLTQLVVTLWYRAPELLLGTRDYGTEVDMWSVGCIFSELLAKEPLLQGKNEVDELSLIFSLCGLPSEKTWPQFYRLPNAKSLKLPREHRNTPAFNRAKFPFLTASGIDLLSSLLSLNPEHRPTANEVLAHAYFKEQPKPKPAEMFPTFPSKAGQERRRKKSPNAPKRGEAPGMQGNLDFSSIFRGREDEEKGAGFQLKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0K435</accession>
    <name>R0K435_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_139287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028659.1">
        <property type="nucleotide sequence ID" value="XM_008030468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K435"/>
    <dbReference type="STRING" id="671987.R0K435"/>
    <dbReference type="GeneID" id="19396501"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="7"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="230"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA84334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="325" mass="33884" checksum="8B11CD5E1DCA5548" modified="2013-06-26" version="1">MSKSAVISVIGSLNVDLVTRTARIPVGGETLASESFNIGWGGKGANQAVACARLSRTKAQASASQASDVEVRMVGAVGQDEFHQGFLKALRDDGLNTDRVEILPGKKTGVAVIVVETGSGENRIMFNAGANGEVPVKDLVDADAGVALFQLELPLQVVLHNMAIARQKGVETIINPAPAVPLPAEAYQGLGHLIVNETEAAILSGIEKPTNWDEVAAVFIARGVKNVIITLGGEGVYYKTAKQQASSQPGVIVPARKVQVVDTTAAGDTFAGAYTVAVARWKAMAQGADFDLDAAIAKANRAASMTVQREGAQSSIPWADEVPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K440</accession>
    <name>R0K440_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_164569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:polyphosphate catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="395" mass="44621" checksum="003ABEC6C05FE78C" modified="2013-06-26" version="1">MTYYNRSHGYPPTRPRPLIEQIPDYRADFDVSDEEDGFHDRDDDFLIPPKLQAALLRTSDRIPRRIKRHSLTIFLLFILTIISWWTYFGPRRAAYYAQVKLMDNAPTMSYDSHVLPEFKGMIQVTDLDEKHLPTKENRLVFVGDVHGCLTELEELLEKVGFDQKRDHLVMTGDMIAKGPDSAGVIKLAQDIGASCVRGNWEDKLLLSIDQAADRHILLPAADAPPDAKIDFIGEATATHGKGKLRKLAKQFTKKDIEYMRQCPVILRIGSVPKLGNLVTVHAGLVPDTPLEHQDPFHVMNMRSIDLETRIPSSKHGGTAWETFWNHRQGKLKPRERATVIYGHNRKKGLNIHKYSYGLDTGCASGGKLTALVIDSQGKTEFVHVKCNKEEGYASG</sequence>
</entry>
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    </protein>
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    </gene>
    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908559">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4F4"/>
    <dbReference type="GeneID" id="19404438"/>
    <dbReference type="HOGENOM" id="CLU_639625_0_0_1"/>
    <dbReference type="OrthoDB" id="3799947at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="39"/>
        </location>
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        <location>
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            <end position="281"/>
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        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="429" mass="48321" checksum="B4E977ED912F93C7" modified="2013-06-26" version="1">MRHTRRRGSVYPTASEQLPPPPPPPPPPPPPPQPVQLHPNTRTIATYPTRHTPHYSASSTTATLTTLIDQHLAWQTHQQAQAEYWRGQDSRGTLFVDWDGHGEAVVSWRREDAYTAVNAKVSRAREMEMEREMEMEEGVGVTRSVLTAQQQQQPSVSDKKKWQRRNAICMPDANLIYQGTKMREIPFGEVLGGAGIQARSTTDTIGRGKEEKVYQDTIREMERDARIHSSTRPPHPHQTQKKTIPKPSHKTKEKDSRTYTTSRRPCSSNPHTKPNPKSPTRIPQLIYLTNTYTNSSLTTPKRINTAPLLTPSPPSYYPLATLNTHRKHSRSVSEGSPLAQIQAPYSRELDRRFNTSFEIVPLGLGREGGSFLVGRSWENGGGCGSGSGSGREKMQLRTRKNISRLVGRAKGRLEVLGEEVKRKGRVWVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4J3</accession>
    <name>R0K4J3_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_180475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029021.1">
        <property type="nucleotide sequence ID" value="XM_008030830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4J3"/>
    <dbReference type="STRING" id="671987.R0K4J3"/>
    <dbReference type="GeneID" id="19401764"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003663_1_1_1"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="747"/>
        </location>
    </feature>
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            <end position="136"/>
        </location>
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        <location>
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            <end position="266"/>
        </location>
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    </feature>
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            <end position="214"/>
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            <end position="249"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="430"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
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    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="EOA83257.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4R3</accession>
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        </recommendedName>
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        <name evidence="9" type="ORF">SETTUDRAFT_171654</name>
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        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">28A</strain>
        </source>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
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        <text evidence="3">Belongs to the FAH family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0K4R3"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA84519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="63762" checksum="8A67FF45FA0B4A24" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0K558</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_20163</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026869.1">
        <property type="nucleotide sequence ID" value="XM_008028678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K558"/>
    <dbReference type="GeneID" id="19402296"/>
    <dbReference type="eggNOG" id="ENOG502SQRC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046320_0_0_1"/>
    <dbReference type="OrthoDB" id="5426911at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Steffenson B.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wang R."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">28A</strain>
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    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028510.1">
        <property type="nucleotide sequence ID" value="XM_008030319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K781"/>
    <dbReference type="STRING" id="671987.R0K781"/>
    <dbReference type="GeneID" id="19396484"/>
    <dbReference type="eggNOG" id="KOG2547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030898_1_0_1"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA84122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="573" mass="64673" checksum="EB92E762ADFCDDCD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7A0</accession>
    <name>R0K7A0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 128 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_172283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027812.1">
        <property type="nucleotide sequence ID" value="XM_008029621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7A0"/>
    <dbReference type="STRING" id="671987.R0K7A0"/>
    <dbReference type="GeneID" id="19401175"/>
    <dbReference type="eggNOG" id="ENOG502SHCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_3_2_1"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353981" evidence="1">
        <location>
            <begin position="31"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="37"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="335" mass="36788" checksum="D1017DE77A555AE7" modified="2013-06-26" version="1">MPRLIPSGRHRQQASLLTTLFTLLSATALAEDSKRGFAFIGDTHKSDNQLLASGSSPLSWYYNWSPYPNSDLIPADTLEFVPTIHGIDATNDDQTERVIRDLPQSSKHLLSFNEPDGSEGSGGSSISPEDAANAYINYVVPFRNGDSGGRKWLISHPSTTGSPNGLDWLRRFNASCYDIDSKNGCPADFVAVHWYGNFEGLTSWLGTLNEFYNINSTRNEPLKLWITEMALPQQDDDDTVAMMNQSLPYLDRQENVERYAWFGAFRTDDSNEWTGDGVALFDDDGGLTELGALYMGNGFKEGQKGEGAEDAASGVKVSIGMMTALFVCATSFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7J1</accession>
    <name>R0K7J1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_155529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028600.1">
        <property type="nucleotide sequence ID" value="XM_008030409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7J1"/>
    <dbReference type="STRING" id="671987.R0K7J1"/>
    <dbReference type="GeneID" id="19397529"/>
    <dbReference type="eggNOG" id="ENOG502TBTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072561_1_0_1"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
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                <person name="Henrissat B."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
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                <person name="Henrissat B."/>
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                <person name="Bushley K.E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9I7</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
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    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
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    <dbReference type="eggNOG" id="KOG1359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_3_0_1"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="36"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="427" mass="46444" checksum="048637A21F4E5175" modified="2013-06-26" version="1">MEDKADAKGLEQTLRQLLDRRRTQTTLRNLTLPKPNQIDFSSNDFLSLSTSPQLKVAYVDELQKASLPLGSGGSRLLDGNSTYAEDLERDIAAFHGAEAGLLFNSGFDANVGLFSSVPQRGDVIVYDELVHASVHDGMRLSRAGTTIPFQHNSVPELQRVLQQLQADHPGVQKGTCNVFVAVESIYSMDGDVAPLQDIVNVAEDVVGSKRVYIVVDEAHSTGVLGPQGRGLVSHLGLEKRIFARLHTFGKALAANGAILLGSETLRHYLINYARPLIYTTFLSYPLLALVRSAYCVLQTGQSNPLQAHLHELIQTLYAELKGIQEASEYALCALKIPSTCPGSPIFAVQLVNPRALASFLQNQGMMVRAVVSPTVPAGTERVRICLHAGNTVGDIRKLVLALQRWCKDRAREALEGEAVNKTASAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDH3</accession>
    <name>R0KDH3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_125334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021648.1">
        <property type="nucleotide sequence ID" value="XM_008023457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDH3"/>
    <dbReference type="GeneID" id="19395965"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA90958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="68652" checksum="593BED1DD28C3AC7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDW5</accession>
    <name>R0KDW5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate-binding module family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_25148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021239.1">
        <property type="nucleotide sequence ID" value="XM_008023048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDW5"/>
    <dbReference type="SMR" id="R0KDW5"/>
    <dbReference type="STRING" id="671987.R0KDW5"/>
    <dbReference type="GeneID" id="19402877"/>
    <dbReference type="eggNOG" id="ENOG502TF6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1686256_0_0_1"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354154" evidence="3">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA91053.1"/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="2">28A</strain>
        </source>
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    </dbReference>
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    <dbReference type="OrthoDB" id="2544694at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="170" mass="18179" checksum="688C787E73CF4A47" modified="2013-06-26" version="1">MSGFPSLQPAFTVQVAIDLPMQVGTQTGSQLAIIPMTSGTVKSEPGFEPKLDAELHGVGYDYIHNDADGANMRLDVRSQLKNHDGTLLAMYYKGHVKVTPGVAALLAHSPDATTTDFGDVFTNFSFETGNPAYAALQNGVYVAAGHFIKEIPGKQGLTVEYKVSKVVYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0KH11</accession>
    <name>R0KH11_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_50590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025152.1">
        <property type="nucleotide sequence ID" value="XM_008026961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KH11"/>
    <dbReference type="STRING" id="671987.R0KH11"/>
    <dbReference type="GeneID" id="19405178"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_6_0_1"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="125"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA87357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="655" mass="71296" checksum="28976E9C624EDE14" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KH58</accession>
    <name>R0KH58_EXST2</name>
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        <recommendedName>
            <fullName evidence="12">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_116387</name>
    </gene>
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908592">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008027627.1"/>
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    <dbReference type="AlphaFoldDB" id="R0KH58"/>
    <dbReference type="STRING" id="671987.R0KH58"/>
    <dbReference type="GeneID" id="19395689"/>
    <dbReference type="eggNOG" id="KOG3144">
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    <dbReference type="HOGENOM" id="CLU_069429_1_0_1"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA87407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26346" checksum="5A52267D22E7780D" modified="2013-06-26" version="1">MANATVINANATSKPQPATAAPIEPLKNDTARLYTHMHPLLVLSVYALKFRALVADPVPTLLSTLAPLAVLQIAFVAVCLPPTGGTPSMRKQKPGEKKGKTPTKLEQGVNSKIVPAFLSLLLTALAATPLLTAILVLFGAPVSTHHAHTLLCGAHVALLSTLPLIYVHGVDGDTWRHIIALLLPMDEVYGGLIGTVLGAWLGAVPIPLDWDREWQKWPVTIVTGAYIGYAVGKLLGGTLLKGKKIMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0KMA3</accession>
    <name>R0KMA3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tricarboxylate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_160218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023665.1">
        <property type="nucleotide sequence ID" value="XM_008025474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMA3"/>
    <dbReference type="STRING" id="671987.R0KMA3"/>
    <dbReference type="GeneID" id="19398017"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF3">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="203"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA89062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32133" checksum="3591DCC6B1E7A111" modified="2013-06-26" version="1">MVSGGNDDNIPAVVSLAAGGVAGGVEGFLSYPLEFAKTRVQLRAESNVPTPRNPFWVVTQVYQQEGIRALYKGCGALVFGSVGKDAVRFLFFDQIKSSFADPETGTLSPLRNLLAGMTAGVVASITAVTPTERIKTAVIDDARNEKRFRSGLHATTTIWKEHGILGLYRGFVGTTLKQASATAFRLGTYNILKDFEKSKNIEQNTAINFANGSVAGIVTTLSTQPFDVIKTRSQSAKGTTTAEAVKSVLMDYGIRGFWKGTTMRLGRTVFSGGILFTSYEAAVKIILPLYPGARQLEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KMX3</accession>
    <name>R0KMX3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_105652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023097.1">
        <property type="nucleotide sequence ID" value="XM_008024906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMX3"/>
    <dbReference type="SMR" id="R0KMX3"/>
    <dbReference type="STRING" id="671987.R0KMX3"/>
    <dbReference type="GeneID" id="19395115"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA89277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34020" checksum="99A3DC07BAFB3DE8" modified="2013-06-26" version="1">MSEQGANDATRASTFTRTLHRTPASGLSPHANTLPPGLNVLVIGASRGIGASMACAYACAGAATLILAARSSSGAALAAVAEQVRAESRDAGTTTTTVLTETIDITSSDSMAQLAARVKQATQGKLDIVVFNSGYSGPIVKRVEEGDPRDFHAVFDVNVQGTYLAAHYFLPLLRESSGGGDKNSAVGKTFIAISSFAACMIEGGLNKVAYCVSKLAQARLVEYIAAQYRDAGVLAVAVHPGSVLTELSGRVFSSPPLANAAADLTDDVKLCGAFCVWLSREKRMWLSGRLLSATWDVDELLEKKDQIQEQDLLKFGYRVGGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRC3</accession>
    <name>R0KRC3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_67622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021943.1">
        <property type="nucleotide sequence ID" value="XM_008023752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KRC3"/>
    <dbReference type="STRING" id="671987.R0KRC3"/>
    <dbReference type="GeneID" id="19405336"/>
    <dbReference type="HOGENOM" id="CLU_854079_0_0_1"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="326" mass="37401" checksum="22F4EB77284E9920" modified="2013-06-26" version="1" fragment="single">CGYFDVQYNRGCVVLFGSEYGKLKSWDGALTHRQDALGFPRAQLLLEAQSKLMGILRQILTKALARIPADPPQGAESLLHCITRYWFWQGVLVEIEHTSALFSRFRDHIAPGSDLPQKFESALGALEAIIDQGIDLRVRQLSSLLRERPGFSDLYEHEYDAATNSSITRVKSCPGMPNPVTEYKTHRLWWCLGNLLAEYENPSRFPYAMLFGILDDHLRTSSANERKKMDGIMYERFTDFATMIKLAEALRFHRPSYAKRQPDDCKVKDDRLGWRRICLANNRPYISWRAANALRNFQKTNPPAGGKCGKWLQAYQANHDALQKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRL9</accession>
    <name>R0KRL9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_178102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020758.1">
        <property type="nucleotide sequence ID" value="XM_008022567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KRL9"/>
    <dbReference type="STRING" id="671987.R0KRL9"/>
    <dbReference type="GeneID" id="19401583"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="92"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="284"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA91629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="447" mass="48780" checksum="279838BB4BD80D18" modified="2013-06-26" version="1">MKNIKRDFHRHGRASSWHQQHNMPEPANGRFHDEHTPLIGRTQNYADESRVKTLPKHIIHLIYATLTSNYVNVFLVFVPIGIIAGALSWNPTIVFILNFIAIIPLAALLSFATEELSAKLGQTLGGLMNATFGNAVELIVSIVALKQGEIRVVQASMLGSILSNILLVLGCCFLAAGIRERESRFNETVASTMSSLMAVASASLIIPATLYAVMHSDSKQTNDATDQNILLLSHGTSIILLIIYILYLYFQLYSHHSLFADVEAQEGGDSEEEAEILSPTAAGVALVIVTVLVAICAEYLVDSIDSIVESAHISKTFVGLILIPIVGNAAEHVTAVVVAYKGKMDLAINVAIGSSMQIALFVTPFLVILGWIMHQPMTLHFQGFETMIFFISVLIVNYLIQDGKSNYLEGAMCIAIYAIIALAFYIYPDDAAGTITGEVIKRFFAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>R0KTZ6_EXST2</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_162015</name>
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    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020545.1">
        <property type="nucleotide sequence ID" value="XM_008022354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTZ6"/>
    <dbReference type="GeneID" id="19398246"/>
    <dbReference type="HOGENOM" id="CLU_2814035_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="67" mass="7270" checksum="91DFC65CB3AA73A1" modified="2013-06-26" version="1">MRGRRLGVWTLTSGVTAVLPLCLPTFLRLSSSPTSVRRSRGKPECECECAAGTWQRAQVSGLMGGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KV87</accession>
    <name>R0KV87_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline-sulfatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_162294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020767.1">
        <property type="nucleotide sequence ID" value="XM_008022576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KV87"/>
    <dbReference type="STRING" id="671987.R0KV87"/>
    <dbReference type="GeneID" id="19398341"/>
    <dbReference type="eggNOG" id="KOG3731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_1_1"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015024">
        <property type="term" value="F:glucuronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051849">
        <property type="entry name" value="GAG-degrading_sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46615">
        <property type="entry name" value="ARYLSULFATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46615:SF1">
        <property type="entry name" value="ARYLSULFATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="98"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="5">
        <location>
            <begin position="545"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA91642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="70100" checksum="1CE70B13E155A534" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KVD9</accession>
    <name>R0KVD9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_162326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020807.1">
        <property type="nucleotide sequence ID" value="XM_008022616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KVD9"/>
    <dbReference type="STRING" id="671987.R0KVD9"/>
    <dbReference type="GeneID" id="19398356"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076142_0_1_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Kosti I."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
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        <property type="project" value="TreeGrafter"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="520" mass="58258" checksum="807FF73B742A336C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
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        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
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    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342157" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA80981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="330" mass="36285" checksum="57AC6695BDB25087" modified="2013-06-26" version="1">MHFPIFTAATLALTSAVSSTPIDPRQATTLNAAMKARGRSYIGTALTIRNDNTEQGIIRSEFGSVTPENAMKWDATEPSQGQFTWSGADAVANFATQNNKQLRCHTLVWHSQLPEYVNQITSNATLMSVMENHIRQVVRRYKGKCTHCDVVNEALNEDGTTKDSVFLRVIGEQYIPIAFRIAAQADPNSQLYYNDYNLEYGTAKHIGAMRLVKLVQSWGVKINGVGFQGHMVSEPTSTQGTVTPSVQVLTKSLQDLASLGIDVAYTELDSCLNVPRCVGMTVWGVSDKYSWIPTTFPGEGSALLWDANFQKKPAYTTFLNVINGQTVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9A9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_34820</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9A9"/>
    <dbReference type="GeneID" id="19403951"/>
    <dbReference type="HOGENOM" id="CLU_1611813_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="165" mass="17315" checksum="0EA4DB43994A24C5" modified="2013-06-26" version="1">MAGEGVGAEALAEVAQAARAGWQAASMGWRHALLARARAPWAGAWRAIVMLGLWLFTHLQCNAGHGRCSRRTHHAQAQRHTHPATAHRGRRAWETAVEGAGDAPRASPKPQSGAMAVAAVTPGGEADGYAEREGEGEGEGEGGRHGTKKQKAGTKPKAHMGYCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9Q3</accession>
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        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_142217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032280.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0I9Q3"/>
    <dbReference type="GeneID" id="19396661"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241013_0_0_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="nucleotide sequence ID" value="XM_008028150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IM12"/>
    <dbReference type="STRING" id="671987.R0IM12"/>
    <dbReference type="GeneID" id="19400904"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_6_3_1"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA86065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="449" mass="49514" checksum="D9F6FA706F41F1B6" modified="2013-06-26" version="1">MAPRRYEAEHKDPAPLGKPLDFAFAKRSAQNRFLKGAMTERLSSWDAKKLEARGIPSKNLVNVYKRWGEGQFGVILTGNVMFEYDHLEAAGNPIIPRDAKYEGERFEMFKELATQAKKHGSLIVAQVSHPGRQVPEKLQKNPISASDVQLEGNIMGMTFAKPRAATEEDIKKVIEGFAHAAEFLEKAGYDGIQLHGAHGYLLAQFLSPTTNQRTDKYGGSLENRARLITEVGQEIRKRTSPNFVLGIKLNSVEFQDKGFDSEEAGTLCKMLEDNTFDFVELSGGTYQQTAFVHQRESTKKREAFFIEFAEKITPSLSKTRTYVTGGFKTVPAMLDALNTVDGVGIARPAAQEPELPRQIIAGEVDAAIKQLTGENDFGTTNLAAGTQIRQLGKDQRPIDLSDEGNLQAFMQDVQKWMQALGSDAEGNMYGFVDIESVPGVPYGSAAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0IMC9</accession>
    <name>R0IMC9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_151740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026509.1">
        <property type="nucleotide sequence ID" value="XM_008028318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IMC9"/>
    <dbReference type="GeneID" id="19397142"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_2_2_1"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF61">
        <property type="entry name" value="CAPSULE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="196"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="496" mass="57952" checksum="0AA2FF1D95D53D28" modified="2013-06-26" version="1">MGRTSQSSHHPVEILIREAQEEFQRLIGRQSKTLESAKTEYQRRYAQHPPPGFDKWFSYAKSKGSLLIDDFDMINEGLSRLWRVDTGRLHENIDHASGLEHLALTKCGFRNGQYFTQGHHWIANDFGNLLKEVSQDIPDVDFLLNLLDEPRIIPTPQIIATGDASKPRFFKANHLPIWNHTIGFCVQDPLSQKPYTTYDFKIPLVRDWYREKDVCLHPEFALTHGFFSSPMTAILTNTHLPILSQAVPTSFGDIVYPSTWYADKMDQGDYDDERDPPWDQKAKKLYWAGSTTGSYSWNGSWRHSHRQRFVKLVQTLNSTNYTYLRESKPGHWVSYQAIEDHNSLFDVKFTDVIQCDLVDCKEQNQFFTVGEREAQIQQFHAQFAFDIDGNSFSGRFYTLLQSRSVVLKQSVFREWHDERLVPWVHFIPISLSMDELPEIMRYMTAHDDGKKRAREIAEAGREWHGKVLRKEDFTIYLYRLMLELARVIEHIRPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0IMM5</accession>
    <name>R0IMM5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_169410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026318.1">
        <property type="nucleotide sequence ID" value="XM_008028127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IMM5"/>
    <dbReference type="STRING" id="671987.R0IMM5"/>
    <dbReference type="GeneID" id="19400896"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01417">
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    </dbReference>
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        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
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            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="510" mass="53767" checksum="843A468A7E2A7FDA" modified="2013-06-26" version="1">MDLSSLKDQVTNLTLYDLKAGFRKAQNAVMNYTEMEAKVREATNNEPWGASSTALQEIANGTFNYQLLNEIMPMIYKRFTEKASEEWRQIYKALQLLEYLIKHGSERVIDDARSHVSLLKMLRQFHYIDQNGKDQGINVRNRAKELAELLSDVDRIRTERKKARANRNKFGGVEGGAMGGFSGSGGFSGGSGGGRYGGFGSESADYGGYRGEVYGDGGGFGGNQSGFADTQQRRERFDEYDEYDEGESATPAPARRKEPSATRKEVKKEEPKPKAPEPVVDLLAWDDEPAPASTAAGKKPATAAHDDFGDDDDFDDFQSAAPAAPAAKPASSAFNMAPPASTSTITSSTQFAAPQAQSVSQNNNLNNLFATVSPPPAANRMGGPPSVASPMAQPPQPTGYQATGPNYFTSVPQPSPQSSSSTPSAMSAGGRIGGAAPKKAGGDAFASLLATAAPKKAATPTQKVTMGDLAKQKTSQGLWGAPAAPSASTPATQTPQSGSNAGGALGDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPP2</accession>
    <name>R0IPP2_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_178689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QSHE">
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    </dbReference>
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    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <dbReference type="GO" id="GO:0016810">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353181" description="Amidohydrolase 3 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="81"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="576" mass="63710" checksum="8CE57950244EAD8F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRC9</accession>
    <name>R0IRC9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_19753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IRC9"/>
    <dbReference type="GeneID" id="19402236"/>
    <dbReference type="eggNOG" id="ENOG502SCX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162806_0_0_1"/>
    <dbReference type="OrthoDB" id="2559882at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="92" mass="9413" checksum="2607F83A136D9696" modified="2013-06-26" version="1">MSSTNQHGQGASHATGDSAVPHKVQEAAPKGLEESLPDGVHPTGSDPSNKSTGKTHALNDGDDSIVPKKVQEAVPESVEKALPNAIHNTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRN8</accession>
    <name>R0IRN8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_161082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024771.1">
        <property type="nucleotide sequence ID" value="XM_008026580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IRN8"/>
    <dbReference type="STRING" id="671987.R0IRN8"/>
    <dbReference type="GeneID" id="19398111"/>
    <dbReference type="eggNOG" id="ENOG502SNJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529102_0_0_1"/>
    <dbReference type="OrthoDB" id="3795566at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA87535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="515" mass="55896" checksum="CEDB194B515B7793" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>R0IS84</accession>
    <name>R0IS84_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_150252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024592.1">
        <property type="nucleotide sequence ID" value="XM_008026401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IS84"/>
    <dbReference type="STRING" id="671987.R0IS84"/>
    <dbReference type="GeneID" id="19397059"/>
    <dbReference type="eggNOG" id="KOG0479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_1"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
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                <person name="Henrissat B."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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                <person name="Ohm R.A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ciuffetti L."/>
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    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA88835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="19400416"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:D-glucose binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="363"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA88835.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="537" mass="58409" checksum="2381B1BB8B8136D4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXM5</accession>
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        <recommendedName>
            <fullName evidence="12">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">SETTUDRAFT_182963</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA89525.1"/>
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        <property type="nucleotide sequence ID" value="XM_008024334.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1202">
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    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
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    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
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    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
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    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
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        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="FATTY ACID SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="ADH_N"/>
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    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="PKS_MFAS_DH"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1407"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
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            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
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        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA89525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1495" mass="161252" checksum="AB011176D956D9D8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXN9</accession>
    <name>R0IXN9_EXST2</name>
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        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="8" type="ORF">SETTUDRAFT_176044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA89346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19401443"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
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    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA89346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="255" mass="28903" checksum="1A17789FB946976A" modified="2013-06-26" version="1">MAVGKNKRLSKGKKGLKKKTDTFAKKDWYNIKAPGTFAVRDVGKTLVNRTTGLKNANDALKGRIFEVSLADLQKDEDHAFRKVKLRVDEVQGKNCLTNFHGLDFTSDKLRALVRKWQTLIEANVVVKTTDDYLLRLFCIAFTKRRPNQVKKTTYAQSSQIRAIRKKMMEIMTRDASACTLAQLTQKLIPEVIGREIEKATQGIYPLQNVHVRKVKLLKAPKFDLGALLGLHGESSQDDSGQKVEREFKETVLDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0H2</accession>
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        <recommendedName>
            <fullName evidence="6">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">SETTUDRAFT_37123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023724.1"/>
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    <dbReference type="AlphaFoldDB" id="R0J0H2"/>
    <dbReference type="STRING" id="671987.R0J0H2"/>
    <dbReference type="GeneID" id="19404220"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="458"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA90485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61458" checksum="D3BDB92720CD3567" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2X7</accession>
    <name>R0J2X7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_152457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020598.1">
        <property type="nucleotide sequence ID" value="XM_008022407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2X7"/>
    <dbReference type="STRING" id="671987.R0J2X7"/>
    <dbReference type="GeneID" id="19397191"/>
    <dbReference type="eggNOG" id="KOG2652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030027_4_1_1"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA91330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="392" mass="44132" checksum="2830ED1ED05E7C7B" modified="2013-06-26" version="1">MSNSVVGGVYQQIMEKVIQASQNDFEESGVDQSTLEEMKQGWQERLSALKIAHLPWDPAPEPVRQPPTVPSNVKVDNDMAPAPAPQDALNFPNAPAKTEGPYQQPIANYPQAQPASNGYSGGYDQNSHLAQQRAAALVQQRVQQQGNVHQQNFPNLAQQGHLPQMPMQGQQQRMMPPQQQQQQQQQQQQQQQQQQQQHQRPPQQPQQQQQQQQQRPPHQNQMYTSQTDGPDDALADWEAFKAARAATAVERMAADDFMRARVDAMAMRQDSGLMVPLDSMPKGKKRKAAVRVLQAEDAAASTHVPAPARFDGDDEAKPEEDPDDAINSDLDDSEDDLNDGDNSDDDMVDYMLCTYDKVQRVKNKWKCTLKDGILTTNKKEYLFHKANGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2Y2</accession>
    <name>R0J2Y2_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_85953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020437.1">
        <property type="nucleotide sequence ID" value="XM_008022246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2Y2"/>
    <dbReference type="STRING" id="671987.R0J2Y2"/>
    <dbReference type="GeneID" id="19405559"/>
    <dbReference type="eggNOG" id="KOG1432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019692_1_1_1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353343" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="416" mass="46134" checksum="FBFBDC2D18146D60" modified="2013-06-26" version="1">MKHTHVLWLVATAVEAAVLQSRYIPNYPGIQFGPDRKLSIAVFSDLHFGEPESQRNRPNADLKTVGVMNSILDNEQPDFVVLNGDLISCEWVAPDDANKFIDQIVAPLTSRNLPFGATFGNHDASRTCSTVSMSEHMWWDIKGKNGKKLSFTTQSVVGEVDKVGWGNYFVPVYSSTNSNDLKMLLWFFDSKGGRKYQPTGDDVGVPSWVDSKVVEWFRNTNNAFREQYGRAIPSMAFVHIPIYATRTFQENSYTRTTNPGINEERIGHQREACGDAGSDCAYTEADTPFMQALVETEGLMGVFSGHDHGVDWCMKWAEDLPGTLPSNGKGLNICFNRHSGYGGYTDWTRGARQIVVGEDLLDEHVVDTWIRLEDGSISGQVSLNATFGTDQYPDVARPKSSALQYRSNSAAASSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2Z2</accession>
    <name>R0J2Z2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_18037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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    <sequence length="207" mass="23061" checksum="1DA2DB836E955DD4" modified="2013-06-26" version="1">MPRTTATTTTTTTTASPQKVQWPATFTDGLPLPKMVVFDLDYTLWPFWVDTHVTAPLKPTEGGLKVKDRYGEGFAFYTDVGGILEALKAKNILIGAASRTCAPDLGREMLKLLKIPSPSGSSSRAIDLFDHLQIYPGNKTTHFERIHRDSGIAFEDMLFFDDESRNKNVEVLGVTMQLIRDGVTRNEIDNGVRAWRRRNGKTNVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0J5A5</accession>
    <name>R0J5A5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_114017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020934.1">
        <property type="nucleotide sequence ID" value="XM_008022743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J5A5"/>
    <dbReference type="STRING" id="671987.R0J5A5"/>
    <dbReference type="GeneID" id="19395616"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="71"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="546" mass="59488" checksum="5AA8A211C0A00D67" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0J5X4</accession>
    <name>R0J5X4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_162601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021030.1">
        <property type="nucleotide sequence ID" value="XM_008022839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J5X4"/>
    <dbReference type="STRING" id="671987.R0J5X4"/>
    <dbReference type="GeneID" id="19398451"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_0_0_1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000014">
        <property type="entry name" value="Catalase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF13">
        <property type="entry name" value="CATALASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="10">
        <location>
            <begin position="50"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA92096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="571" mass="65586" checksum="D6251F0EA8CA75BF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0JK44</accession>
    <name>R0JK44_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_35486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030697.1">
        <property type="nucleotide sequence ID" value="XM_008032506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JK44"/>
    <dbReference type="STRING" id="671987.R0JK44"/>
    <dbReference type="GeneID" id="19404024"/>
    <dbReference type="eggNOG" id="KOG3981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_1"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA81658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="393" mass="42192" checksum="ABE3DB6D45465FB5" modified="2013-06-26" version="1">MSAAVPSPEAAGPGAATNPHPIPLTESEVLIRGFLAANPDLDLDDPSPIEIMTDRYTNDEWQAQIDETTKQVLKEVESGKRAKKIYQGPRMRNGDEALRQLAKAIDHTVLKLDATSTAIDALCSEARTENFKSVCVRLNWVQRCVSNLKGTNVVVACVVGFHEGTQDTKSKCREARAAVKAGAAELDVVLNYSLLTKHNNTNNKRHPQSRDSAIDSITAANTAKNAAATASTHTYDEPEMPDYSAIYRELATIRSLCPNTTLKLILETSQLTWAQILAASHLAAAASFDFIKTSTGFNGAGATLPNVQLMVAAAEYLGARGVSRRAMQVKASGGVRELDTAIKMLESGATRLGTSSGLWIMQEAKAKVAAGLATSPDRKPASVTRLYTDDSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0JL06</accession>
    <name>R0JL06_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_72231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030181.1">
        <property type="nucleotide sequence ID" value="XM_008031990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JL06"/>
    <dbReference type="GeneID" id="19405367"/>
    <dbReference type="eggNOG" id="ENOG502SZ3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037962_0_0_1"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA81968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="303" mass="34448" checksum="E8E130BF20F1793A" modified="2013-06-26" version="1" fragment="single">TGGDFDPNVWADDELWNKYLAKGQRLMCLMDATDQGAGYLMQDTRQPPSAASRWTTELETWHWDEEPLYADWDCDFEAKSLSTVFQALGINPYPAYDDDGEPADGENECYVVSHAEFGSGVPVRDQRYHVNGREYRATGAAYDFAVNQKDGLIVALNIMSPSAAVQNRFGWGRKAEPGELPELHRLSDIYWGFWFRGNNHLNAFKYYLAHHVVNPDTVKLITRALRNRRKFALTFWPGVAFTIGSPEHQAIIASPIGATAAHFLITHKPFLGIKRITKINVFHDDYRPDEVMLMFTIEDVPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLW0</accession>
    <name>R0JLW0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_97154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
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        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
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        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA82223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="424" mass="47494" checksum="C738F7EBD686A737" modified="2013-06-26" version="1">MSKSLSPYDSLRYIPLCYDYADSHKTALALILALRPEWQDSKDTIEFVRFTDGITNTLLKAVNKLPGLSKTEVEDDAILLRAYGKGTDVLIDREKETRSHSLLARHNLAPSLYARFENGLLYKFIQGSVCSPADLRRPEVWRGVAQRLGEWHATLPISSISSTCPAPAQLTSQNNKRESLAAMAALTPGKPIPNLWTTMQKWILALPTTTTAQSERRDQLMQELSSLTEILGDTPGIGGSNPFVFAHCDLLSGNVIIEPSPSSASASRRSSVSSGSDEPEPVACVSFIDYEYATPAPASFDIANHFAEWGGFDCDYSAMPTRTIRRAFLREYLRSFSAHHNKSYNNADLDVLFDQVDRFRGVPGFYWGIWALIQAQISLIDFDYASYAEIRLGEYFAWKKAFDGGKEEDNERMMLREKIWASDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNZ5</accession>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_173543</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA82928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008031722.1"/>
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    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="395"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="513"/>
        </location>
    </feature>
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            <end position="516"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA82928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="521" mass="56317" checksum="513058E9D7D9B520" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>R0JPY0</accession>
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        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">SETTUDRAFT_155793</name>
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    <organism evidence="10 11">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EOA83233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008030814.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Yeast_MetPath_Reg"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
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    </dbReference>
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        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="282"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA83233.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="664" mass="75431" checksum="690DE22E41989ED6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUI4</accession>
    <name>R0JUI4_EXST2</name>
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        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
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    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_99669</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0JUI4"/>
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    <dbReference type="eggNOG" id="KOG0157">
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    </dbReference>
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    <dbReference type="OrthoDB" id="6692864at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA81149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43194" checksum="EF6D2EAF8B6E4C1B" modified="2013-06-26" version="1">MYDLEQPNRGIATRDRGLHAARRRLWSRGFGDKALRAYETRVAVYVDQLLARLARAHGEPVDAARLAEAFAFDVMGDVGLGSDFGMLQSATMHAAVEQLVQGLSIMGRRLPVWLMRLLVDVGQSLVPTEATTGFLAFCYHHLDRLMLMADVERAKRPSLIAPLIAHYEQQPPLHRDLSALRNDCRFIIVAGSDTVAATLAFALFYLAKHPQHVLHVRKELQPLRRANAAYADHQLRDAAPYLNAVISETLRLHPPASTILRITPPEGITVAGNFIPGDMTVFSSQYAIGRSETLYVDAASFRPERWHSDPSLVKDASGYAPFSMGPHSCIGRPLALMEMRLVLAETLSRYSVSFAPDFDHGSFPDRVHDCMSWHIGNLDLCFTPLVDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWR5</accession>
    <name>R0JWR5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_165485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="143" mass="14333" checksum="B7693C37FFF801B7" modified="2013-06-26" version="1">MTLQKIEVINASPGGSYEYGDKSGSWQSIKVSDKKVQDKFPASLSASVSASASASPSSSASAHKSGTQSSHSPQATGADKSDSTKDGNTHTDSSSASPVAAAAQATSSASPSAKPEQSNDAGVESVQWKFTAILVSLAALVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0JY86</accession>
    <name>R0JY86_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_34019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029417.1">
        <property type="nucleotide sequence ID" value="XM_008031226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JY86"/>
    <dbReference type="STRING" id="671987.R0JY86"/>
    <dbReference type="GeneID" id="19403848"/>
    <dbReference type="eggNOG" id="KOG1576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708168_0_0_1"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="75"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="390" mass="42253" checksum="AEA5A5037E049384" modified="2013-06-26" version="1">MPIALDPITTGNVRGKWKRKNIHQPSVQAIFLIVVVVHVDINVVVVVIVVHTSGPRFPPPKRRAAVNAFGPPARHDVEFVSPAEVLEAVRELRRIRDEEGTIRYVGISGYPLDVLGDLAELILRETGEPLDAVQSYANFTLQNQELAGPRGVQQLHKAGVDVVPNASILGMGLLRRQGIPVGGLGDFHPAPSSLREAVRRASDFCDAYGEPIEVIALRFALETWMSAGALCGSQGDPASGVPWQHESIDDVGGSKLGVSVIGVSCAAELEKTMLVWRSILDGLDGGQQTAVQAGRWSRAWEWSCNRRKAVQILAEGVEEILGPGFGYAWPSPGPDYVNKRVKNVNLATRIKKTDAVEQHEAPWLTPAASPQALPVNIPEHVVEDKALPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYF8</accession>
    <name>R0JYF8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_157217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030780.1">
        <property type="nucleotide sequence ID" value="XM_008032589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYF8"/>
    <dbReference type="STRING" id="671987.R0JYF8"/>
    <dbReference type="GeneID" id="19397710"/>
    <dbReference type="eggNOG" id="ENOG502QRRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024655_2_0_1"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA81267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="379" mass="42126" checksum="563B31310C29B8D8" modified="2013-06-26" version="1">MLGYISSTRKKSCTACVKAKRRCDLGYPFCKRCFVKGLDCSYPNPSKTPVSVRDAEVVIRRTTPDISLPATTAHHHVGAHEPGNIALDPLALAASDESTLEAWLQDGDGCSTTPELCRTLMPSVALPVILNNQQTIIVVEGLCALVNHMAYSGTTHFLHRNLYPHDAQPAAYQDCVAIAALYMAQNVRNTSILVNSINAKISIMIREARNWTLMNHLAAVQALIIYQIIRLFDPSLGAQADAVKHNALLETWATDLLKRSFYDTLSFPDAHARWVFNESLRRTVFMSVFTRCAWSVFTKGGLADQVHILAAMPLTKDLGRWTRQDTLCGIESIPSKDEDLVSYLDLSRDWSYDKSVKELGPFGKFLLAPCRGDDQRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYT0</accession>
    <name>R0JYT0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_96499</name>
    </gene>
    <organism evidence="12 13">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029696.1">
        <property type="nucleotide sequence ID" value="XM_008031505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYT0"/>
    <dbReference type="STRING" id="671987.R0JYT0"/>
    <dbReference type="GeneID" id="19406242"/>
    <dbReference type="eggNOG" id="ENOG502SM9Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044863_0_1_1"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025076316" description="Pectate lyase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA82604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="307" mass="33743" checksum="1EB91DC4810F140E" modified="2013-06-26" version="1">MKLSASVIIPLLPVIATAAVIRRQNGDGPQGSTDSTQGDLGVRPPPRFPFPVTKFPVPTETVVLEEAMYILPGQVFDGKMKRYERPEGSCSEQAEGTDADAVFNLLPGATIRNVVIGKHQSEGIHALGDAWVENVWWEDVCEDALTSKGLNTQLRVIGGGARNATDKIFQDNSLGGKVNITGFFAENFGTFYQSCGNCLNQAKRNVTIQDVIAVNGTRMGIISPNYGDEYRIKDSQVADVERYVDKEIGNNVQTVPYTVGTGPDEKYALYNLTRDHITEFEGEILNQYVPEEPYEWLGDFWKEGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZ61</accession>
    <name>R0JZ61_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_140979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029778.1">
        <property type="nucleotide sequence ID" value="XM_008031587.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0JZ61"/>
    <dbReference type="GeneID" id="19396596"/>
    <dbReference type="eggNOG" id="ENOG502QQX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001419_0_0_1"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="837"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1740"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1740"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1801"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1816"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1844"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1859"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1891"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1903"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1944"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1961"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2003"/>
            <end position="2021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="2046" mass="229856" checksum="97760C867718173D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZE7</accession>
    <name>R0JZE7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_96759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029832.1">
        <property type="nucleotide sequence ID" value="XM_008031641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZE7"/>
    <dbReference type="STRING" id="671987.R0JZE7"/>
    <dbReference type="GeneID" id="19406263"/>
    <dbReference type="eggNOG" id="ENOG502S19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074138_0_0_1"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="264" mass="28231" checksum="549BB6E74F7D3070" modified="2013-06-26" version="1">MASTVNVENISTKTTEEEIKVFFSFCGKIQSLSVKPAGDDTHSASITFEKEAAAKTALLLDNTHLGPNAIRVTAAKSLDELAGDKAASAEEAKDGEHHIEQEQKPRARIVAEYLAHGYAISDKAIERALAADKQNGYSTKFKTFIDTFDKKTQATQRAQVVDQKLGVTNKGYAAFNTLTSYFDKAASTPTGQKLRAFYEQGNKTVMDVHNEARHLANLKKQKAAGQEGAAAGAVTTTTAEGSEKPSQPLSEKPGEPATAPAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZQ6</accession>
    <name>R0JZQ6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_28391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
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        <property type="protein sequence ID" value="EOA86378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025894.1">
        <property type="nucleotide sequence ID" value="XM_008027703.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0JZQ6"/>
    <dbReference type="GeneID" id="19403243"/>
    <dbReference type="eggNOG" id="KOG0981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009193_1_1_1"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000019">
        <property type="term" value="P:regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="425"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="752"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA86378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="903" mass="102568" checksum="B652736382AE196A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZX2</accession>
    <name>R0JZX2_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_166112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0JZX2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="421" mass="45050" checksum="1C950CB6FEDAECC1" modified="2013-06-26" version="1">MKSLFLLLPLLGTILALPQDIQGSNCEANCPFVRCETDDPQKLCECINNRESLCKEICPTYEPVFVACPPLPTPIKAADPAPSTCVCEPVFCIQSWPESCYCENDAKKACYDKCGGTPPTYATCPPRTVTAREPEAAPEAAPETCKCDNTYCTQVWPDSCYCANDAKKACYEKCGGQIPTYNTCPPRGVSARAPAPVPAPPAPTHEPLCVCEEVMCIQSWPESCLCANDAKKKCYDKCGGVKPVYQDCSPLDDITAVPRSAEPTDECKCTEIQCLQIYPEGCYCANYAKELCYKECGGEKPVLESCPPISIPSLTTKTIHPTTAVAAARRATPTNQVCGGGRGSPHPDCPSGQICITNPFDKGSCGPACDQTGICVEDKLCGGFGGFACKKQGQICVDDPRDDCDSEHGGSDCAGLCVWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0Q3</accession>
    <name>R0K0Q3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 20">Inosine-5'-monophosphate dehydrogenase</fullName>
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            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SETTUDRAFT_88414</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">28A</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 20"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025305.1">
        <property type="nucleotide sequence ID" value="XM_008027114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0Q3"/>
    <dbReference type="STRING" id="671987.R0K0Q3"/>
    <dbReference type="GeneID" id="19405704"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_1"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
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                <person name="Han J."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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</entry>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
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        <text evidence="8">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
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        <subcellularLocation>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="86"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    <sequence length="271" mass="30390" checksum="D87AAC012078888B" modified="2013-06-26" version="1">MPVTQQRDASWNSMQLEQTPSHPKHSSHESTKDLLEATDADNNRYLLHSAERKPFFLHPSMWMWEVVSIVFSVLIFIAIVTVLVIYNGKPSPVIGAVTLNAAIAFAATFFRMSLMVPVTSCRDVSFKLRSTFYSGLYSSGMTSLPYPPYSCTTGNCTWDPFPNLGVTVQCCDNSADYSLNYSEAVSDIWPEHPFRPCTIANIHTGVSALPTEYPPPPLELASPTLVFSSDTSYQRWSPDEHFGSNYTLANGFPEEWRHNWTSIHAGFAKFK</sequence>
</entry>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82937.1"/>
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        <property type="nucleotide sequence ID" value="XM_008031729.1"/>
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    <dbReference type="AlphaFoldDB" id="R0K3I1"/>
    <dbReference type="STRING" id="671987.R0K3I1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Aldolase class I"/>
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        <property type="entry name" value="OxRdtase_FMN_N"/>
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        <property type="entry name" value="Oye-like"/>
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        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
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        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="366" mass="40847" checksum="161CA94B58DBB9DB" modified="2013-06-26" version="1">MATSRLFEPLQVGNMELKNRVAMAPLTRFRANDKHEILPMAAEYYGERACVPGTLLISEATLTSKKAGGYDHVPGIWTQGQIDAWKLVTKAVHEKGSYIYLQLWSLGRTADPNYNKRNGIPMKSSSATPMDKDSVVPEEMTVEDIKESINDYAQAAKNAIEAGFDGVEIHGANGYLVDQFLQDVCNKRTDSYGGSVENRSQFAVEVTQAVVEAVGAEKTGIRLSPYSKFQGMKMEDPLPQFTDIMKKLDALNIAYVHLVESRIAGNTDVDNVESLDPLLPHFTGKLLIAGGFKADSAKKLVEEHKERDIVVVFGRYYISTPDLVFRLQKGIDFNPYDRDTFYLPESAKGYLDQPFSKEWEEAQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3K0</accession>
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        <submittedName>
            <fullName evidence="11">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_155423</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
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    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA84129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008030325.1"/>
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    <dbReference type="STRING" id="671987.R0K3K0"/>
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    <dbReference type="eggNOG" id="ENOG502QQ16">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="430354at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0000139">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
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    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
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    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA84129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="450" mass="51290" checksum="873E0D5DF47EEB9B" modified="2013-06-26" version="1">MLFTTSHSSIPRLLVIPLFFCISGFLFFTSKYYGSVGMHMSMLTGNNITAASSTFGAPVKHFWSELATALLDAQPQCEPLKLDDEGFESFINFVPLEPHKKHPNRLVNFTDNEETALFRAHYAMRTSASNLAPHVPFTKDTTGIVTTANAKYMPILLVSLRMLRRTGCDLPMEVFIDDWSKYDATVCDTVLPSLNARCIVLSNIYDTAADAKAPEHYQYKAFAILFSSFQHVLFLDSDAFPSQDPSGLFKTAPYTTHGLVTWPDFWAQSISEHFYHIAAIPEVASQSRRSTESGQLLINKDVHRETILMMRTPFFDYKYLPPMRNHIHDQAFWQDADLENADSSKKQRNRALKIPTKPRPLFIHQNTLKLDPATVIGDSKLYEADGSPHRMWGKKENMEKDIGYDIEQRVWEVVIEEGCRENPDGETCKKIRAWYYDVFGRINTSDMPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4P4</accession>
    <name>R0K4P4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_91536</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027134.1">
        <property type="nucleotide sequence ID" value="XM_008028943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4P4"/>
    <dbReference type="STRING" id="671987.R0K4P4"/>
    <dbReference type="GeneID" id="19405909"/>
    <dbReference type="eggNOG" id="ENOG502QW7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043316_1_0_1"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="250"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA84504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="309" mass="33117" checksum="242D82A8D0CA6220" modified="2013-06-26" version="1">MPAYGSSASPTLAKMENGGYGQRASGFSIGRIFGDPFALATISIGILAWIISFVSSIISAIHGGFPNFAWWTLVFMFFCIVGVTVTVASNAERTYHVAIVGFLSAGLVFTTSSVNSLVYSPVTPFEAAAAGYILLSMIAIVWIFYYGSQPQASHRAFVDSYALHKESAGSRSSRPISNGYTNRPETQNANMAPQMYTSAQLNGFETSSPVSGYPGGPAGANGRNSSAPAFGGMNNQTPTNDDAQQEASIEYPYRAKAIYSYEANPDDANEISFQKHDILEVSDVSGRWWQAKKPNGETGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K603</accession>
    <name>R0K603_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_168351</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023868.1">
        <property type="nucleotide sequence ID" value="XM_008025677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K603"/>
    <dbReference type="STRING" id="671987.R0K603"/>
    <dbReference type="GeneID" id="19400510"/>
    <dbReference type="eggNOG" id="KOG1224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_0_0_1"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="347"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="548"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="750"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA88453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="927" mass="103545" checksum="2B0B59EB6515C8EB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6K3</accession>
    <name>R0K6K3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_92363</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028401.1">
        <property type="nucleotide sequence ID" value="XM_008030210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6K3"/>
    <dbReference type="SMR" id="R0K6K3"/>
    <dbReference type="STRING" id="671987.R0K6K3"/>
    <dbReference type="GeneID" id="19405970"/>
    <dbReference type="eggNOG" id="ENOG502SHAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343126" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="370" mass="36988" checksum="470E788129055131" modified="2013-06-26" version="1">MVVLTAGIFLASLAASASAAPAVKRAQTCTFSGATGAAAAASAAQSKCSTITLSNLAVPAGQTLDLSKLADGTTVIFDGTTTFGYKEWVGPLVSIGGSKITVKGNPGSVLDGDGARWWDGKGGNGGKVKPKFFAAHGMTSSTISGITIKNPPVQVVSINGANGLNIVNFTIDGSAGDKLGHNTDGFDISDSTNVVIDGAKVHNQDDCVAINSGTHISFTNGYCSGGHGLSIGSVGGRSNNVVDSVTFANSEVANSDNGLRIKAKVGKTGKISNITYNTIKLTNIAKFGVLVEQNYNNGDLHGKPSTGIPITGLTLSNISGDGAVSSGGNGVVIACGSGSSCAGWKWDNVNISGGSKSSKCINVPGAAACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6R7</accession>
    <name>R0K6R7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SETTUDRAFT_46850</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023783.1">
        <property type="nucleotide sequence ID" value="XM_008025592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6R7"/>
    <dbReference type="STRING" id="671987.R0K6R7"/>
    <dbReference type="GeneID" id="19405085"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006412_1_0_1"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="143"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="425"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="740"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="558"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EOA88673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="957" mass="106086" checksum="77A689AA17D65FBD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7P4</accession>
    <name>R0K7P4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_160162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023617.1">
        <property type="nucleotide sequence ID" value="XM_008025426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7P4"/>
    <dbReference type="STRING" id="671987.R0K7P4"/>
    <dbReference type="GeneID" id="19398014"/>
    <dbReference type="eggNOG" id="KOG4098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113004_1_0_1"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA88998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13747" checksum="B5634A0F60DF36F6" modified="2013-06-26" version="1">MASQAQLKKQQELQTTYQNYKNTLQTIASKIGDIEQESEEHKLVLETLQPLSGDRKCFRMINGVLTERTVKEVVPILQTNSDGLKKALDELVKQYKSKQDEMEKWKKKNNIQVVQQPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7P7</accession>
    <name>R0K7P7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_40269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908692">
        <property type="protein sequence ID" value="EOA85544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026824.1">
        <property type="nucleotide sequence ID" value="XM_008028633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7P7"/>
    <dbReference type="STRING" id="671987.R0K7P7"/>
    <dbReference type="GeneID" id="19404606"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA85544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="465" mass="50982" checksum="779393A9DA1902AB" modified="2013-06-26" version="1">MAVLAVSHETSRPLKDLPEVERVKLLAAKLRDSLKESTVLTPDSEGYAKSIQRWSDAVEMQAEYSVSFAVCGGKHSSSGASSSTGGLVIDRGKMRAVKVDTENNIVKAQGGCIWEDVDHAAAEYGLAMVGGTINHTETRTLGGGYGWLSGRYGLTIDLLLSVQMVLADGTTVTVSKDEHPDLFWAVRGAGHCFGVAVEFTFQAYPQKNQIWGGQMVFPASTRLEAVIDFANRLLETTSGDSAMVMGITHPPFMQELAVIATVFHNGPEVEALKVFKPLLDLAPRVNTVKERPYREMNSVMNHAVDYGGRKLSKGACFKTPLRAPFVRSLMEELQRLHSQVPGSKKSIMLFEFFHTAKLNSVASDATAFANRGTHQNLMFGPFWDRAEDDVAVRVWARGVAKLAKTELELAIQGTNEKIGEYGNYDAMAAKPREIFGSNLERLREVKAVYDPNNVFNKSYALITPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7V9</accession>
    <name>R0K7V9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_160209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023659.1">
        <property type="nucleotide sequence ID" value="XM_008025468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7V9"/>
    <dbReference type="GeneID" id="19398016"/>
    <dbReference type="HOGENOM" id="CLU_2924173_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="61" mass="6612" checksum="867BA7C78C0C592D" modified="2013-06-26" version="1">MHACKSGMQVIQTAGQGKAKQDKTRDLTGKRSRAPESLFACNADAPDSDKEGGDISKYKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9L3</accession>
    <name>R0K9L3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_37328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
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        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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        <property type="project" value="InterPro"/>
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        <source>
            <dbReference type="EMBL" id="EOA89763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="334" mass="39099" checksum="7647F7431BBB2931" modified="2013-06-26" version="1">MSPNTDPYTRTLIVALKSPSVGKSTSQISELTDVHPRTVNRIYSRAIEAGFEPNVLPLKILPEHDWTLEDWKNVIWTDETSVVLNHRAVVKSCIRERWKGYSEFMFWGCFSYDKKGPCHIYQPETNVERKDAARKIEQLNAELEPLQREEWELSTSMRRTGLRNKPGRKPQWRWTEQTGKLVRSSKGGIDWWRYQSCVLIPKLIPFAKECLQDRPQTVVMEDKAPGHAHQYQNVVYSLSNVERLLWPGNSLDCNCIEPCWFYMKRETTKKGAPQSRTEATRIWLNCWRDLPQAKIQAWIERILIHILKIIELQGGNEYIEGRDRRCVGERPDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA58</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_20612</name>
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    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_655809_0_0_1"/>
    <dbReference type="OrthoDB" id="3634414at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="419" mass="44719" checksum="FECCC8926C36E300" modified="2013-06-26" version="1">MDLLEHLGAGVTNRLLPRHQLTIAMHQISIAALQKAVRNNLQRISHVHTHSQGSSASFHSPTVSLLSGLAAASPAPLAVQRDTASGRIDACNKNTCSQEAGECPAYGGKAVGYPECVVYPSDQLGTDRGYPRTPSGQVQAWFDFPQPDAGCRYILRSPAGVTTYENCGIPKLTVTSAVCQLATLESTFMLQFCCGQGDCNAATGIGKRQDGSSVTPFVLNDKDGKPIAGIMGKSGDEMSIMSLNVTTPQQARSVAAMPEVRSLHEVHSLAKRDCNFVKTEGPYTKLADKSEYVAGPFSCPQGGTCEQTVEKSYSISRSISASVSVSDPFGIISASLSVDFEKSYSYSISKSFSFPESSTGYVSSTPVLECYRGYFDGCDSDNGNVFEACQRNPGNPKAVDTAVITRSKKRSAEVEEIVL</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="5">Sin3-associated polypeptide Sap18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_163826</name>
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    <organism evidence="3 4">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027583.1">
        <property type="nucleotide sequence ID" value="XM_008029392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KA77"/>
    <dbReference type="STRING" id="671987.R0KA77"/>
    <dbReference type="GeneID" id="19398907"/>
    <dbReference type="eggNOG" id="KOG3391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064128_0_0_1"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29993" checksum="17B12CD380355E92" modified="2013-06-26" version="1">MAAPAKIDRQTTTPFLLRLFFKQGSFHRQVTANRRATVTLTGPRLDEFDPTLPRLPTNVQIYTWQSCTLRELCQLLLSAVPSMLPQPYAGARIAFRLVYPDIQGSNRPGAPGRYISRDIGSVIVGAPSRHDDVDMEGSDGGSVAEALRQLDGDPDRSLADVKFLIGDYIACAILPPLPDGGVPAAPPPLSGPGRGPPPGSYGGRGRENGFGGRGDWGGGYGRGGRGGGRFDDRRMSGGGVPSGEWRRGEAPPERESGFGRGRGRGGGDDWRDRGRGRGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAY2</accession>
    <name>R0KAY2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_145611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022019.1">
        <property type="nucleotide sequence ID" value="XM_008023828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAY2"/>
    <dbReference type="STRING" id="671987.R0KAY2"/>
    <dbReference type="GeneID" id="19396820"/>
    <dbReference type="eggNOG" id="ENOG502RYWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030268_0_0_1"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF11">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="473" mass="52265" checksum="1A32D463BD0A7A5F" modified="2013-06-26" version="1">MPPASSPSVSHFNEPFISALDAAAPSNASDDPSYYARYPRTLVTTSNLDTFMTGTGSAIYQSLVPLLESANHELILVTCFWARSATLDTLNHVLRRLSDKAVRRGTDKIRVRLCFSSSSLFQKLFHNQAITGQTYPPATWVSKLGLPDPSELNGLNLEIKSIFLMPFSVMHPKFIIVDRQTAVLPSCNISWEEWFEGAVTLSGPIVSQFLKFYRTFWERRQDEPTTLDAEPLTAVKPVEALQSSIQLSSTNTPSIFLPSPHRRNPHFSLFAPQDALQAPPTPLNTFLLTLFANAHRTIRIQTPNLTAPPVLAALLRALARGIHVTILTSARLMILEQLVTAGTTTHRCMAKLIKRYRALCSTYHRHDTSSVDEETAMAATQPGTLHVSFFEPMGGARGKGDERGEPQQSHLKMTVVDDDVVVLGSGNLDRASWYTSQELGVAFFGADLVRGITGSVDEAVEGRVKVLFDSRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBC8</accession>
    <name>R0KBC8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_134923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025301.1">
        <property type="nucleotide sequence ID" value="XM_008027110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBC8"/>
    <dbReference type="STRING" id="671987.R0KBC8"/>
    <dbReference type="GeneID" id="19396280"/>
    <dbReference type="eggNOG" id="ENOG502SKH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_3_1"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA86674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="387" mass="43267" checksum="1BDFC0CDFF1D0809" modified="2013-06-26" version="1">MNADNTQEWPNQRLKVMIPMWTLLALSTIFLAWRIAYGFAQRRRFMLSDYLLIIAAILNIAAITVAQIVVDNGLGRHIQDPTVLPNIMTYVYYLWITQVLNIIAMAFLKWAICAWLLVLNFSRVYQAVIWLSILMVTALNFLAPVLTLFGCTPFERNWNILYKGKSHCWAKSSIQLSYTQGISNILTDVVYMAAPLIYLSRIQISRRTQWGIRAVFLLSIPATICSIFKTVELKTLTSTKDPTWDGLLPSTLTGSGKTPQYDYSTGGAAAGNSIQMNNFQGSKAYHSRIRGESVLDEDDESDRAILDDQDVKMHGIMKSTDVEVRISEAGPPRGSAIAHYGEGSSSNRSRSDSGGVGHSPKGFKEPQIDWSSPHIESRRGNGIQHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBE8</accession>
    <name>R0KBE8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YjgF-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_162896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025327.1">
        <property type="nucleotide sequence ID" value="XM_008027136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBE8"/>
    <dbReference type="STRING" id="671987.R0KBE8"/>
    <dbReference type="GeneID" id="19398579"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="19804" checksum="58DB3A9BD8E169E0" modified="2013-06-26" version="1">MHMLQRVAFSRRLIGSAAKSTSTATTLTLLPRSRPQLRLPIGNRAISQEQVRNMSGIKSVFTANACPPAGPYSQAIIAGPSIFVSGQIPADTKGNLIEGSIADKTKMCCENIKGILTEAGVSLDRVVKVNVFLDDMAHFAEMNGVFEQYFPHKPARSCVAVKQLPKGVPVEIECIAYNGMGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCP7</accession>
    <name>R0KCP7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_110827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026520.1">
        <property type="nucleotide sequence ID" value="XM_008028329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCP7"/>
    <dbReference type="GeneID" id="19395449"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF101">
        <property type="entry name" value="HIGH-AFFINITY NICOTINIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="497" mass="55164" checksum="402FD4950ED4A624" modified="2013-06-26" version="1">MNTGTKDECPSKENAMALNTTTTNGSLGEALSESYYIDPLKERKMMRKFDLYAIVAMGILYMMSNLDRSNLGNANIAGMPKEIGLTGNQFGIATTLLFATYVPFEGPVAVMLKVIGPKPLMTTCAFCWGVVCLGMSFIQNHYGLYACRLLIGFFEAGLIPCVNVYIGAVYKKSERGQRSSFIFAFSAFSSAFGGLLAFGLTQIRTANYSGWRWLFAVEGAITIMVVPLFWFIFPTTPTEAWFLTEDEKQMMHIRYASDPSWGFDDRFAWSECLKAFVDPKWYAFFAYQFSINISLYGLTTFMPAIVRGLGYTSYHANLMTVPIFFVALVFFLALAWASDRTEVRGPFLIIGLVCLIAGYSILLTVNNLKVKFFACFVVAALGIYPTTGLSIMWLQDNVSRHYKRATMVGFTLTLGNTAGVAVGQIFTAQSAPEYLPSIRIALGMACFALVDVCCIMTAFKWINRKRAARLLAAEQAGSPIESDASLGDYDPHFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KD92</accession>
    <name>R0KD92_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_64485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="50" mass="6198" checksum="246AD4939E363B16" modified="2013-06-26" version="1">MSTKHTVKYKLPVKHRYPVALYQKLAIHVARAKLSQRPQRREYQFNFRKW</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA88634.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="340" mass="38618" checksum="CBD3A55B2B0C4C7E" modified="2013-06-26" version="1">MVLASKLDRNLRAAEESSDGEDYYEVTDRSSSASVIDADEGGNVISSDEEDAGSEDMSDVDDNQVKAQMSKVSFGALAKAQDALSQQSSDRKRKRGDDTSKSQEDKLEALRERLRQIKAEKLASGAQPSKKAKSSSKSKTKAVANETGGDRDASDDDSDSDAAPHARSSKHAPAVQSSKRMVSRKRNVVEVKKPVFRDPRFDSVTGPRPDEHVVSERYSFLNDYRASEISELRNTIKKTKNEDEKERLKKKLMSMESQQKARDYKDKLQEVAREHKKKEKELVKEGKKPFFLKKSEQKKIALVERFQNMKSKQRDKVIERRRKKVTAKERRNMPDTRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKB4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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    <organism evidence="2 3">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Glaser F."/>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="983"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1023"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA88627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117118" checksum="407B9BC594F4502B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KL98</accession>
    <name>R0KL98_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_168004</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023423.1">
        <property type="nucleotide sequence ID" value="XM_008025232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KL98"/>
    <dbReference type="STRING" id="671987.R0KL98"/>
    <dbReference type="GeneID" id="19400386"/>
    <dbReference type="eggNOG" id="KOG0833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_1_2_1"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="77"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA88742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="185" mass="19936" checksum="BE6B1F9940C9ABE9" modified="2013-06-26" version="1">MSATTIPTFTPGESVKEENGLIHGVSVAELQVLGEQCFEARERAYCPYSLFRVGASLLLTTSTPSAPSATHTITGANIENASYPVGTCAERVAMGTAVMAGHRLGAFKAVGVTTDIVDYCSPCGMCRQFLREFLALETPIFMFNKEGKWIVRTMGELLPLSFGPDVLPPREELRKGQDADKAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KM35</accession>
    <name>R0KM35_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_145710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <location>
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            <end position="696"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="426"/>
        </location>
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        <location>
            <begin position="482"/>
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        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="173"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
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    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
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        </source>
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            <dbReference type="Proteomes" id="UP000016935"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA89162.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
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        <property type="entry name" value="UreF_sf"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="EOA89162.1"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="450" mass="49502" checksum="1401F116D6B0AF68" modified="2013-06-26" version="1">MASNVLGARDTNAHMRPMRSPEKADMKSLDYHRQVLQSRLKDKQEPKYVSPSDDIMSPATQKLQAFKNKHAMKKSKPQTLFKKTSSKNLEAAKNSGKLEFADIPKREADEGQAETGNVAKPRPVPVRYLAASPSRPTKMKAPQHQQDQDALHDEIADLERRLHHAKARLNPAAPVATPPSPLSEAGHVPRHHPWAATMDHDTALHALLLLADSALPLGSFAFSSGLESYLAHHKPVTPSASQLPAFDTFLRLSLSTLASTSLPYVLAAYRDPELLESLDNDFDASTPCTVARRASIAQGRALLAVWDRSFRAHYDASKHHPTEFGPSPQDDAVRALGAFSAALRTSEHLNAHLAPLWGLVTSILHVPLQQAAYLFLFSHARTVISAAVRASVMGPYQAQAVLASAELQDRIRGLVDEGWDRTVEEAGQSVPVMDLWVGRHEKLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNR6</accession>
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            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
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        <name evidence="3" type="ORF">SETTUDRAFT_144717</name>
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    <organism evidence="3 4">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021476.1">
        <property type="nucleotide sequence ID" value="XM_008023285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNR6"/>
    <dbReference type="STRING" id="671987.R0KNR6"/>
    <dbReference type="GeneID" id="19396781"/>
    <dbReference type="eggNOG" id="ENOG502S3AM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343385" description="DJ-1/PfpI domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="136"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="282" mass="30240" checksum="3EB1DD4BD89E5897" modified="2013-06-26" version="1">MHYHKPYHLLTAISLLTPTLGAPLQPPITNSSALPTHYGLLVFPHYQALDIFGPMDLLNSLFMMYSNSTPAPQLSVLSRTLAPVTSAMLPGGFGQEIVPTTTFSQYLCEHTSADTAARRNCTDTSSSSSAPVRSAAKASTDIDVLVVPGGGGTRRDMSAEIAFIAATYPRLKYIISICTGASLLSRAGVLSGRRATTNKRSWAWATSHGTNITWVATARWVADGNVFSSSGVSAGTDAMYAFVGSVYGEAVAEYMGWSLEYNRVTRWDEDPFAAVWDVPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNX2</accession>
    <name>R0KNX2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_166675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021523.1">
        <property type="nucleotide sequence ID" value="XM_008023332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNX2"/>
    <dbReference type="STRING" id="671987.R0KNX2"/>
    <dbReference type="GeneID" id="19399895"/>
    <dbReference type="eggNOG" id="KOG3282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_0_3_1"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="193" mass="20250" checksum="1275C1E831A57E79" modified="2013-06-26" version="1">MTESTQPSTANIAAACAILAGVTGYMLGQAKSLGFFGGSPISQPARSEKSKANESEDESSDEEDGSTPAEFPGQEECKMVLVVRTDLGMTKGKIGAQCGHATLACYKHFLRTAPDSQILKRWEIKGQAKVALQVKSEEELELLQAQALSLGLVAHIIHDAGRTQIASGSATVLGIGPAPKSVIDQVTGNLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQ03</accession>
    <name>R0KQ03_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_101057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021745.1">
        <property type="nucleotide sequence ID" value="XM_008023554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQ03"/>
    <dbReference type="STRING" id="671987.R0KQ03"/>
    <dbReference type="GeneID" id="19394829"/>
    <dbReference type="eggNOG" id="ENOG502R106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037431_2_2_1"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="360" mass="41412" checksum="36A08EDE6BC6CC4D" modified="2013-06-26" version="1">MMQEADYPDETKSQFLTFYRNTICPLLATKPRPDSRPTAVGWDGNPFEYSFEFKASTKKTGVRFVLDLSEYRPPNLENPLSLETVEKVLDVLSAKSPLYDDHWHRALERWFAYSNRSSERQKELVAKVGYQTPTILGFDINPKITKLAPHMLPVMVKSYFPPCFVSADRGFSRFQSLALGVRQLPDVGCHPNILLGLKMIEDFVADNPQYENCGRGLSTDFVPAGKARLKVYLRYWGDSFDEIWDYYTLGGRIPIADIENDKEIMRELIALSRGSEYSAEKIRKESEQEKKRRAIFGTKPTSLYFSLTPDKPYPIPKLYFYPAYQAPNDEAIAQGIDIWFKKWGWYDGGSSLEQKVQNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQ95</accession>
    <name>R0KQ95_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_166995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA90022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQ95"/>
    <dbReference type="STRING" id="671987.R0KQ95"/>
    <dbReference type="GeneID" id="19400007"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_3_1_1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="136"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="593"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA90022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="773" mass="82687" checksum="5F5E08EB0B8359CF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSK4</accession>
    <name>R0KSK4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_162505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="R0KSK4"/>
    <dbReference type="STRING" id="671987.R0KSK4"/>
    <dbReference type="GeneID" id="19398412"/>
    <dbReference type="eggNOG" id="KOG3294">
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    <dbReference type="HOGENOM" id="CLU_066296_1_0_1"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31605" checksum="BDE3EBE8ABF38B28" modified="2013-06-26" version="1">MGFISEKSMTKTPSNRKSSWVMLAENGAYTPLPGEQTLYQSPPRTSLSLQTSNRHSPSQSYSQQCKSGIVFLTNRRVLYLPVNPTPQLQSFAVPILNVTDSRVTAPWFGANKWEAVIQPVQGGGIPPQHSELELVLEFKEGGAFDFASIFERLKERLRQAVETARESGGDVQDGRRGVGGVDMNNVHLEDLPAYEESRQHARVPDPLPSPPMDHPTGGVGAGGPVVAAPEPCSPQASSSLSSPRTQQEHFEPPSDPPPGYEEVQRNSVVDELERQVRDNPWQDGDSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RIBV">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="200" mass="22797" checksum="791D42EE06941773" modified="2013-06-26" version="1" fragment="single">IRRRILDSVSAFDAAKLVNLKLCVLTAKEKEKYLKPIRDLVWDVPAVERLSREGMKLMLLGDGAHALEQRLHATERYLNSCGNERLTIYLLGTFPVFTPTATTLDSLVEFSTTGHSNLVRFYCDKYQLGRVRAVPDTDAKGDFLMSFSVPMQASTDPTKGSWYKVDDVPDRTVDLWVYVPSLRDRLCKEVRLIPLDVLRM</sequence>
</entry>
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            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <location>
            <begin position="32"/>
            <end position="61"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="581" mass="66130" checksum="5D11ACA079D4E8F7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTM0</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502R6AG">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA92269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="157" mass="17736" checksum="B43E451BE2600E56" modified="2013-06-26" version="1">MCVKVLDYEVFAQWDAVEAVLQGVREMGIVVERLWDTVDDTRVGGGDWNARVRPGWNVKVLCLENGVEELGGGFEEEDEESAGAGGVEEGEGRVWGAAGWLGRKEKETAWWFARWRERVEKEIRCHGHLRDPSWEMVVGWCFSMVTFVVMVSVLCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KUA6</accession>
    <name>R0KUA6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_113113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020628.1">
        <property type="nucleotide sequence ID" value="XM_008022437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KUA6"/>
    <dbReference type="STRING" id="671987.R0KUA6"/>
    <dbReference type="GeneID" id="19395586"/>
    <dbReference type="eggNOG" id="KOG4008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036234_1_1_1"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="217"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA91382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="338" mass="37564" checksum="3D066472CE784312" modified="2013-06-26" version="1">MAPTAPQPTKKPKPIPKTIAEFTILPLTLPPLPGLPDHCNNATHYLYVKPHAPSIPSVSDERSLFIVNVPIDASEQSLRALFLEHLGGSMVERVDFDASVPAAPMHKRWKTDTPRAPPPGTDGAGGDAARGKKRKRADDPAIVAEGVVEDAESALPKLWSTEIRRSGSGTVVVFVDRKSARGALREVQKAVKEGRSIVWKGEQNLGVERYTTHLTHTYPTASSLQASLNAYLTQFSALESMRSRLRKTARSAPDADGFVTVSRGAGARTGPARIQDALKKKEELDRRRANHRATDDFYRFQNRERRKRAEGELKKRFEEDKRRVLGMRETRGRVRPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KW65</accession>
    <name>R0KW65_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_133969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020975.1">
        <property type="nucleotide sequence ID" value="XM_008022784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KW65"/>
    <dbReference type="STRING" id="671987.R0KW65"/>
    <dbReference type="GeneID" id="19396230"/>
    <dbReference type="eggNOG" id="KOG0633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_1"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="77"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA91992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="434" mass="47349" checksum="835EC3DCF1A5F325" modified="2013-06-26" version="1">MAARNTAFNLQTCARPNILALEPYRCARDDYKDDGTNILLDANENAYGPGLALAGDNKINGNGTGDSSYAIDVDLLGLNRYPDPHQEELKQQLCNLRNTHTHTAKKITPANLFVGVGSDEAIDALIRAFCVPGKEKILTCPPTYGMYSVSAQINDVALVKVPLQLPSFDVDVPAILAALDSDTSIKLAYFCSPGNPTGKLLNKQDIQQVLEHSWNGIVVVDEAYIDFSPDGTSLAEWVSEWPNLVVMQTLSKAFGLAGIRLGAAFADAAVAQILNNMKAPYNIPNPTSQLARAALSPKHLEVMRRNKDMIVAQRERLMSEMKSIPGIGQLHGGTESNFLLYQVLDGPAEQGGKPSNEAALAVYEGLAEEKGVVVRFRGKEYGCLGCLRITVGTEKEVDRFLDELRQVLRRVHQRMGGVGKDEEQRERKANDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="14" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">SETTUDRAFT_162643</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021070.1">
        <property type="nucleotide sequence ID" value="XM_008022879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KWV2"/>
    <dbReference type="GeneID" id="19398468"/>
    <dbReference type="HOGENOM" id="CLU_2623548_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA92162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="78" mass="8503" checksum="DC9FE9ECDCD71A40" modified="2013-06-26" version="1">MAAARGCPRDDAKATGGETFVFKQPWLLLAHQPTASQTARLGRARVVVLRLRTVPRILEFAMQKDIVTCAATGRHAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0I549</accession>
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        <recommendedName>
            <fullName evidence="8">Velvet domain-containing protein</fullName>
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    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_35618</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0I549"/>
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    <dbReference type="eggNOG" id="ENOG502S1B4">
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    <dbReference type="OrthoDB" id="1746739at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF11754">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="32"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA80691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="334" mass="36939" checksum="34C0A359733CDCB0" modified="2013-06-26" version="1">MAASMAHYPGHHPSRIGTARPETVAQPAYPPRRPERKYELSVEQQPIRARMCGFGDKDRRPITPPPCIRLVVYDETGRELDFNDIDSTYFVLMVDLWNESGQSAVNLVRHSSAAPTVSISSSTTTSYPPPPERSHYVATTIPAYDPQPYRQQMQPQQMPPAYGHTPVPVAQYYPQPPTPSYQQYPAAPYAQTPTQSSMIPATPMSSNHTRNLIGMNAVNACRLNDINNKPGFWFVLQDLSVRTEGTFRLKLFLFDIGAGDGTNATVSNDGPTRGKGKCLAVSFSEAFTVYSAKKFPGVIESTPLSKCFAQQGIKIPIRKDGPKLPNQAEYDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0I621</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031202.1">
        <property type="nucleotide sequence ID" value="XM_008033011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I621"/>
    <dbReference type="GeneID" id="19402800"/>
    <dbReference type="HOGENOM" id="CLU_888934_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="313" mass="35007" checksum="8A7C116097308198" modified="2013-06-26" version="1">MEYGDMFATSPPTTRRQSMTSQRPATDTEPRRYTRPVDASFGHRLATARNQAHGDALPTLSGEDWRAAGAMPASQVGESVRETTQLPLRVPPYGWERGSYRSPFEYNIPGHHVGANTNPASRPFPHTRPQSISFGSMPPIDTRTPPSMASRAATLQHKPEPICRAVTPGPDTKERLLLLGPLLVIQNTCATLCREDREMLHSFLDKYMGESLRTVVERDALLPQVIYKISIPMTDGNWQKYNQLLSVFAFANSMHKMLAVGSEEFDKYSFVVDAESGTGHVESWKALASARSRGLSMEMLLQELVQTWKKTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6B8</accession>
    <name>R0I6B8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate-binding module family 35 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_144310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA81061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008033415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I6B8"/>
    <dbReference type="STRING" id="671987.R0I6B8"/>
    <dbReference type="GeneID" id="19396753"/>
    <dbReference type="eggNOG" id="ENOG502QW2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016116_1_1_1"/>
    <dbReference type="OrthoDB" id="9970295at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-galactosidase CBM13" evidence="6">
        <location>
            <begin position="360"/>
            <end position="432"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA81061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="448" mass="47850" checksum="56845B737FF109B2" modified="2013-06-26" version="1">MYAFGLAGLALVASVAEASLQIVPGATWTATNNGQGVQAHGGGMFKEGNKWYWVGEDKTDGSAFQNINCYSSSNLVDWAYEGAILSRTASGDTGPNRVIERPKIVHNKKTGKYVLWMHIDSSNYGEAKAGVATGDQVCGKYTYIGSSQPLGFQSRDSSVFVDDDGKGYLLSEDRQNGLRIDALSDDYLQVTSSVHLFSDDYEAPALVKKNGVYFMFGSKLSGWAPNDNRYSTATSLAGPWSAWNTFADVGSNTYASQTAFVLPVGNNFMYMGDRWHSENLMRSTYVWLPLTISGTTATMKNHVSWIINPSTGAISTAPSENTYQGPSATLANGAKVSTCSSCPSSTSSFAGNIGGPSNGSATFTSVQSSVATRTTIRIVYRNGDSKQRYAMVTVNGKTQTIAFFPTVDSDPGTSVANVDLKQGTNQITIAGINGGWGPDVFRVIVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6E1</accession>
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        <recommendedName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008033466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I6E1"/>
    <dbReference type="STRING" id="671987.R0I6E1"/>
    <dbReference type="GeneID" id="19399823"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025741_5_2_1"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="241"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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                <person name="Bushley K.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="19402557"/>
    <dbReference type="eggNOG" id="ENOG502RGCP">
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    <dbReference type="OrthoDB" id="3438340at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021641">
        <property type="entry name" value="DUF3245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11595">
        <property type="entry name" value="DUF3245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="110"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="234" mass="25549" checksum="F80216CBC66800F0" modified="2013-06-26" version="1">MAKRSSDGDVLANRISLLQAKGQTLLASLYGSRPDWDSGDTAATAQDEDDQDLKHNYAHDRIGLGGVLPKDVEDGSFTRRIPTSDDKLLQQLIGKKKAKAHIAAKQQAARLGAAAKAQQYSKPAAKKEASDDEDEGRAATFKSRRQKKDEASKVVDSDDEDEETRAKRLAAGANQKENVVTDAPADDKPSQKEEEDQEPDVAQPASKKARTKPKSFLDEILAERSKKKNKKGKP</sequence>
</entry>
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    <accession>R0IBF6</accession>
    <name>R0IBF6_EXST2</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_165077</name>
    </gene>
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        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031488.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19399353"/>
    <dbReference type="HOGENOM" id="CLU_1856544_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="138" mass="15310" checksum="0A355175F02C42F3" modified="2013-06-26" version="1">MAAAEEQRTLRIAPTTPTLHESKIPHNPLDSLPDGVTTCWAAVATQQWKTEVKDGTVKHDDPVHTTTPTEAMSFRGLAVSSDNRLTKRECLYACRRSCSALGSTYLRWFSSNSSMLRKTSESMKSFVEKVEGSVRAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBG9</accession>
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        <recommendedName>
            <fullName evidence="17">DNA repair and recombination protein RAD26</fullName>
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    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_140809</name>
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    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA82596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029689.1">
        <property type="nucleotide sequence ID" value="XM_008031498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IBG9"/>
    <dbReference type="STRING" id="671987.R0IBG9"/>
    <dbReference type="GeneID" id="19396583"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_7_0_1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000039">
        <property type="entry name" value="DNA repair protein Rhp26/Rad26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="410"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="744"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="208"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="961"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
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                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <source>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0IDK2</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA83216.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
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    </protein>
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    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
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    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="22">28A</strain>
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        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
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        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
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            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
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            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
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        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008030140.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0IEY4"/>
    <dbReference type="GeneID" id="19395760"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="10262326at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycosyl_transferase_4"/>
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        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004352998" description="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" evidence="20">
        <location>
            <begin position="26"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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            <end position="158"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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            <end position="232"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
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            <end position="258"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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            <end position="321"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EOA83860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="458" mass="51303" checksum="6BF538DAC5D100DB" modified="2013-06-26" version="1">MTSALTWTESLSLLSLSAACMGVLANTLHGDGEPLIASIAFSGLAFVSCYALIRWLGDAFMRRGFKGKDLCKLKQTELPETMGAVCAMVYLFIIIFFIPWPFYKDIVVATSGGGNRDMIKELELIETGRLLHRFPHNKLASYLSAILSLQSIVLLGVGDDLFDIRWRHKVLIPAFAVIPMLVVYFVDFGVTQMVVPVPLRPYLGELFDLGWIYYVYMALLSIFSSNSINILAGINGIEVAQSIVIAVLIVINDVLYLSPFTPYPHPATDSHLFSMYLLLPFIGVSLALLRHNWYPAKVFVGDTYCYFAGMVFAVVAILGHFSKTLMLLLVPQAFNFVYSAPQLFHIVPCPRHRLPRFNARTGLLEPSRVEFTKPLAKPIAETLKLLHRLRMLNVQVNADGQVVSSSNFTLINLWLVWFGPMREDRLAMGLLVFQFAIGLLGLFVRHRMALLIFTADNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0IG60</accession>
    <name>R0IG60_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_21346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004352954" evidence="1">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="315" mass="33323" checksum="C6E334DE0C862E9E" modified="2013-06-26" version="1">MLSLLPTLTLLSLPFLAASQSASDGYTGYKLNVRDDGDPAAVLYETANTRTSNVSALNPVPDVLLNASVHVGEIFVGVDNLTAKINLDASVLQLLQFNAGVDLSVDKVSLLIQNVTAKVYLEARLGNVVSMIGDVLDSIDLNPVIAELGNGLGDILDDAGDLVGGITDGITGGGSGSGSNQTAQAKAKRDIDFHQWDLRNNILYSINNFEGNTHKRRVLAQNGDIVEQMLDNTGAISGSTVVGNYAKDMKFNGFNETVTFKGEEVFEEEYVYEPFLGLYSVSGVFKSKTTGQVVGTQLLAEARGGGSAIIGNEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0IH02</accession>
    <name>R0IH02_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_92749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA84271.1"/>
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        <property type="nucleotide sequence ID" value="XM_008030424.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343109" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="514"/>
        </location>
    </feature>
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        <location>
            <begin position="70"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="514" mass="54960" checksum="D5CEDB57E8472313" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0II95</accession>
    <name>R0II95_EXST2</name>
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        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_163527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029036.1"/>
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    <dbReference type="STRING" id="671987.R0II95"/>
    <dbReference type="GeneID" id="19398787"/>
    <dbReference type="eggNOG" id="KOG1463">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
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        <property type="entry name" value="Rpn6_N"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036390">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
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    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
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        <property type="nucleotide sequence ID" value="XM_008029101.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="88"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="292"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="446" mass="50755" checksum="3951C4B13869EFC3" modified="2013-06-26" version="1">MTTVKGNFVAEKKDATIARNKKIKKARIEAMRIASDELLAKARAAFENSQEYEGVVVEPMLSYESCDAASLPWCLKEQAREVPPMDVLNEEIDRFYAYAKPNEFEQTARQHVIQQVRALVRKALKKCDVEVFGSERNGIPFATSDIDLRLLWPSQVSRPSMARLPPTKRERGKGMAQLGWLYNGSLKHNRDYLLTSLRHARYPLVAAQDRQSGLDVQIVLSNDTSVSRDYMQRYMQEIPYLRSLYYVVKTIFDIRGLSDVFRGGFGSYSIFMMLVASLKHAPHQRQDAAGGLLNFLKFYSDFDAKAHGISIEPVELFDKVQHPVITNPVKISFKNGTAKPLPSYMLCLRDPADETNDLGRKGIAIKHVQTTFNALYTQLVMDLKTNTRASLLASLVGPVYMLNIERRKKLQDYGWRLQNSKHASLAATAKAIREEEKRSKRGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IM16</accession>
    <name>R0IM16_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_161606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026451.1">
        <property type="nucleotide sequence ID" value="XM_008028260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IM16"/>
    <dbReference type="STRING" id="671987.R0IM16"/>
    <dbReference type="GeneID" id="19398177"/>
    <dbReference type="eggNOG" id="ENOG502RBVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030965_1_0_1"/>
    <dbReference type="OrthoDB" id="2119662at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052031">
        <property type="entry name" value="Membrane_Transporter-Flippase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549:SF2">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN NORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="476" mass="52982" checksum="CEE83FC2BC9FACEF" modified="2013-06-26" version="1">MSLVSRYLGALIFNFATFILPVLYSTLPKLWVANIDSSLVVTTDVYTYIGVVAEVLNKGLPRAAWVIIGDKASRSLPQRLKLTHTLILFQSILGLIMSIAFMSAASTFAKGFVPVEVRAASLTYVHISAFSALSSAIEVAVSTSTRALDKPNVPMIISSVKFAINILLDLLIISRFHVGSFKPSVNMQAGIQLACNLSAAFVGLCYFIYITSFRALAAIEHYRPHENILPSLRALKVLARPGIITFTESAIRNALYLWLVSGIVAMGSEYATAWGIFNTIRWGLIMVPVQAFEATSLAFIGHNWGRWRRSIGIDMHRAKADRRTIFQIIRPALISLLIALAIEVPLCIFLSFFGTRPFARYLSNSDAVAKITARMWRTIDWCYIFYAASTQLATILLATRPRWYLYQSLASNLLYVLPWAIVCQVAHLNVGDAWTYHSLVFGGSLVFSFFDILLVDGIWAWTLVTGRIRLEVFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IM76</accession>
    <name>R0IM76_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Manganese lipoxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_184889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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                <person name="Barry K.W."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Han J."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <strain evidence="4">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
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        <source>
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    </evidence>
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        <alternativeName>
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        </alternativeName>
    </protein>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023882.1">
        <property type="nucleotide sequence ID" value="XM_008025691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IV11"/>
    <dbReference type="STRING" id="671987.R0IV11"/>
    <dbReference type="GeneID" id="19400513"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="520" mass="59002" checksum="79E1FCACAC7223DF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVD3</accession>
    <name>R0IVD3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_149229</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023950.1">
        <property type="nucleotide sequence ID" value="XM_008025759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVD3"/>
    <dbReference type="STRING" id="671987.R0IVD3"/>
    <dbReference type="GeneID" id="19397008"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
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        </location>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA88561.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110140" checksum="0BF7F2EF8A08E345" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0IW23</accession>
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        <recommendedName>
            <fullName evidence="11">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_46538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="EOA88985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025173.1"/>
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    <dbReference type="STRING" id="671987.R0IW23"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein"/>
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    </dbReference>
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        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EOA88985.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51024" checksum="A9A81E160F397B79" modified="2013-06-26" version="1">MKPIRALLPTLLAAGRAAAMPQRAASQHPLLDASAKQSAQTLGVGHFSEWSRQTKKEFLIDWQAGKESDWILVQGNEGGDLDSMTAALTWAYHLEHATMNSSNPVKAIALLQTPSHALDLRPENKLALANSQMTRGHEDLLTLDELPEDPETLSTKLKGIVLVDHNAPLRKWSQAKIVSLFDHHKDRGTAPDAEPRIFETTASCTTIVARQMLDELESLDQEYHMPHELLELILSAIAIDSGGLSNDKTTKADIDTSRRILARSNWRARDLDDIMEDLDDELSKAQKDIDHLNLYDLLRRDWKSDVIDTPSPRTPTVSVGFASIPYSMDEQILKTDFQELFDWFAVHAAWTAQADVDVSVSVNKYKKSYKDGTKEKIREVVLVVRDDVRIDQDQADSLFAVVKEAMENNGLDIDFQPWHRADELAPRQMVWVHTSNAGRKAIRPLVEEAVMGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IW61</accession>
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        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
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    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0IW61"/>
    <dbReference type="GeneID" id="19396056"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
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    <dbReference type="OrthoDB" id="2496787at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="430" mass="47575" checksum="6ABA761420D93839" modified="2013-06-26" version="1">MLALALLVAFASCFYAVIAQEAAGFDASYQEPWVLNVSVGGMFDEMPFCSRVCSLAVLESTGCHPLDTACFCATPTMAPGIESCLSWFCPVLAYYEGSSLYHTTCNTGIRNSSAPLVSTVTAVATIAFVAVTLRFLTRIPPLSIKWGADDWLVLAMVPIAAFFLASILKAVDLGFGQDIYMLTPRDVAEMTKYYHFEELGYVLLTFLTKMTVLTFYLRIFPIGKIRQVVYAFIAMCTCLLISIFLAHFLQCVPISFIWEQWEGTLVPKPKHVVCGVNRDNLNFVFGITNVIMDGSIMVLPIPRVLKLDLRWQKKIAVLFVFCIGFLITGIAIARISILLNGSYTNNTSWNLVPVVKWSAIEIFLSIAITCFPQMHVLAKALLGTCIKFDTATNNRPGKLSYGVSSSMHTGVSHSKKQPEVLYENLELGFK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
    </reference>
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        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
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        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
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        <location>
            <begin position="41"/>
            <end position="153"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="207" mass="23452" checksum="F910EE9520E757E2" modified="2013-06-26" version="1">MVHILKRMRKLREKLLWIRCGPGALILPKEVSKITMEFNAKIYGGHRGARKFWREMLPRIKYRNPSVPIQISRHTDADGPSVLHIYTASKTQPAPGTTNAPTNQQSNAAPPSGTPNPRNTLVPDTSKPTYTIDIRDQMESEILEALVARTGAQAIEPTEQELAEMQEIAEAKERSEADRVQVREYVMKQRREEEMLKLARGEVPTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0J229</accession>
    <name>R0J229_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_36324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19404116"/>
    <dbReference type="HOGENOM" id="CLU_113784_0_0_1"/>
    <dbReference type="OrthoDB" id="3676096at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="153" mass="17150" checksum="B8C28B42CA39AB03" modified="2013-06-26" version="1">MGSQETIPDDTLYPKYQSSLLFRDNIDYPASGLAELAQASKQSNDKKSEEQPGECTSHETKKGVCYTNAGYKPEESGTEIAGLFDELKDVDKQMRHLQDKKEILVSCLQEAFKRTTQNTLHISGKLVRWADSTGTSSLNDDTCRPRKKARRSS</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_86902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA91470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3C5"/>
    <dbReference type="STRING" id="671987.R0J3C5"/>
    <dbReference type="GeneID" id="19405614"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343759" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="508" mass="54866" checksum="95F2C680C1CFF675" modified="2013-06-26" version="1">MAGIASLALGTLLLGAQVARCAPSADTTQACNDINQALPGKVLTPSTLGLAYTQETQQYWAVNLRSVNPACIVQPSSAQDVAIVIGVLNKYPTVRFATRSGGHDPNKNHTTVQDGVLITMTNLVGATYDADEDVAYVRPGGEWNDVIGDLEKSGVAITGGRLGLVGVGGLLLGGGLSFLSAQEGMAADNIIEWETVMANGSVVNVNAATHPDLAQAMRGSSNNFGIVTQFKAKVHHMGNVWGGSCFYDTTKADQIYAALHNFIAHGAEDPKAAIIFTDLNLATGIRSRLIFYFYDGPTPPTTGPFAEFLKINNSCILKTRTYSDLLKTNGQTVSLLNARSFFRTKTVPYIASRPQMYREISDKLSNLTSPVLGLAPVISGIQFSVDMQPLPAAIGKISESKGGNAMGLTASDPDRIILIFQGAWNLASEDEKVFQIARNLTDWLDEVVPQWLEEAGMPADMYMPYFINDAMYDQPVMQSYRDYEKFKTLQQSVDPNGLFSTRTGGFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3N5</accession>
    <name>R0J3N5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_162090</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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</entry>
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    <accession>R0J5Q2</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">28A</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
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        <location>
            <position position="456"/>
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        <ligand>
            <name>heme</name>
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        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA92235.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58748" checksum="FD6D4145594D91FB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0J5R9</accession>
    <name>R0J5R9_EXST2</name>
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        <recommendedName>
            <fullName evidence="9">CDC45-like protein</fullName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J5R9"/>
    <dbReference type="STRING" id="671987.R0J5R9"/>
    <dbReference type="GeneID" id="19401063"/>
    <dbReference type="eggNOG" id="KOG2475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005871_3_0_1"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="protein sequence ID" value="EOA82918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029903.1">
        <property type="nucleotide sequence ID" value="XM_008031712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNY4"/>
    <dbReference type="GeneID" id="19397640"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_2_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF2">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE AUSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="620" mass="70105" checksum="C367E8097CE79C31" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JTZ9</accession>
    <name>R0JTZ9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_136419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027149.1">
        <property type="nucleotide sequence ID" value="XM_008028958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JTZ9"/>
    <dbReference type="GeneID" id="19396357"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF66">
        <property type="entry name" value="MFS HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="531" mass="59816" checksum="ADC79AD279C54029" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUQ6</accession>
    <name>R0JUQ6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_142562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030756.1">
        <property type="nucleotide sequence ID" value="XM_008032565.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0JUQ6"/>
    <dbReference type="GeneID" id="19396675"/>
    <dbReference type="eggNOG" id="KOG1517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001136_0_2_1"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000278">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="5">
        <location>
            <begin position="148"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="888"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="936"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA81239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1401" mass="156960" checksum="7D110FC5E54CF885" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWC2</accession>
    <name>R0JWC2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_32464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027033.1">
        <property type="nucleotide sequence ID" value="XM_008028842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWC2"/>
    <dbReference type="STRING" id="671987.R0JWC2"/>
    <dbReference type="GeneID" id="19403655"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="85"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="500" mass="55231" checksum="9563BDFA569B948F" modified="2013-06-26" version="1">MGGGDGGGGETIADHILKSFQLPDVVPSPTSSKPLINLLRGHLPLRPVANRTRWPNLSLLPTQLLDRATHRVLQHRPTAYPALCYGPDEGDPRLRNNIAHWLTAFYAPAEPVSQNRICITGGASQNLACLLQDFTDPLYTRNVWIVAPAYMLAFRIFEDAGFHTKLRAVPEDPEGIDMDYLATQIRKSEDKAASEGNSEPLLKPRRPFNKIYKHIIYAVPAFSNPSSKTMSLRRREQLVRLARQYDALIITDDVYDFLQWPSSLTPSTLSIEKASLPRIVDVDRYLDGGAERQGADGFGNAVSNASFSKIFGPGLRTGWCEGTPKLAYAVSQTGSSRSGGSPSQLTACFVAETLETGELQRYVYNTLQPAYGSRYRHMVEAIHKHLTPLGVRIPQTDREVVGGYFIWLTLPLPLKGADVAQRAKQDSNLAVAQVPGDTEHAGTCFGNDIRVCFAWEDEDMLVEGIERLASVISRMLQKDANGGQKLTRPVTCEDDAKALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWU5</accession>
    <name>R0JWU5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Purine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_44630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031287.1">
        <property type="nucleotide sequence ID" value="XM_008033096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWU5"/>
    <dbReference type="STRING" id="671987.R0JWU5"/>
    <dbReference type="GeneID" id="19404939"/>
    <dbReference type="eggNOG" id="ENOG502QQ5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_3_2_1"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF3">
        <property type="entry name" value="PURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="449"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <accession>R0JX59</accession>
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    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA80852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="265" mass="30363" checksum="0EF8AB66E73BAB3A" modified="2013-06-26" version="1">MDPEPEGFRSSTETTTSLHAWTDGENISLIHRNHAEIATRKGWKYRYLWHGLSYTTVILLTSLISIFISMKGYTRSDCSCSLDATSHTGSLQADLVMVNSTPDEPVENALSNEMKLQKAWDTLAERSDGVTVVVPEKLEQERGILPESPKVTRNGVSGYLVTLDSMHQANCVDAAWRRLWFNHEDDKLHGPMANHNISDQWYKDHITHCLKILKQSILCKMNVDMVMGYIQWNKSDPNDFIHFEKNHICKNYTKVLGWIKNKEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXK0</accession>
    <name>R0JXK0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_165650</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA82209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXK0"/>
    <dbReference type="STRING" id="671987.R0JXK0"/>
    <dbReference type="GeneID" id="19399540"/>
    <dbReference type="eggNOG" id="KOG2013">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Uba2_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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        <name evidence="1" type="ORF">SETTUDRAFT_24071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030636.1">
        <property type="nucleotide sequence ID" value="XM_008032445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZS7"/>
    <dbReference type="GeneID" id="19402737"/>
    <dbReference type="HOGENOM" id="CLU_2814039_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA81682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="67" mass="7117" checksum="20258FBF07AE4F04" modified="2013-06-26" version="1">MGVMVVFEDEGAFDYKCFDIGYIGVGISVGIGVDGGVGSGNLPRTLIPTSTVSGRQTKMQPRDLMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0K131</accession>
    <name>R0K131_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_155922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029116.1">
        <property type="nucleotide sequence ID" value="XM_008030925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K131"/>
    <dbReference type="STRING" id="671987.R0K131"/>
    <dbReference type="GeneID" id="19397571"/>
    <dbReference type="eggNOG" id="ENOG502QQGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_2_1_1"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019622">
        <property type="term" value="P:3-(3-hydroxy)phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="242"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="456" mass="50460" checksum="7E87AFE87F9E883F" modified="2013-06-26" version="1">MSSESVNKDAKAGGISPNGETIPVIIAGAGPVGLLLALLLARKGIASKVFERGSEVDTSPRAADAGIYDIVRERGFQSGGHVWRKPIVDDGKGGKALGPAIAELKLGEPGPDGSYKDGECCIIFTQGRLVQVLLEEAAKTGLVEILFSTPITGIEQDESGVTVQVEASGQPQSFRSRGHSWPERLIAVDVLRTLPKLEETPAYFAVDKVHWGVIIPLEPIFPGKPGLWRYGMAIPDEKMTAEEAQDPKYVEELLLRYIDGPRPVEHTVVRSRLYRLHQLLASTMHRGRVLLAGDAAHVNSPVGGLGLCTGLLDVDILSQALDLILNHDYHDPQDLLAEYSAARRFVFQNFINPTSTANKLRLHESDPDNAAQEDWFLRMVRKGDRQEIANALAPLQRRHENWSVVEIPKVHYWDMVVYYYSDAVAAMGYRSTEEDREQAETRNRQSGEVRIDENRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1H8</accession>
    <name>R0K1H8_EXST2</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_165698</name>
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    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA82277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030533.1">
        <property type="nucleotide sequence ID" value="XM_008032342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1H8"/>
    <dbReference type="STRING" id="671987.R0K1H8"/>
    <dbReference type="GeneID" id="19399555"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_0_0_1"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Manning V.A."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <location>
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            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="121" mass="13593" checksum="029909EEEF9B4763" modified="2013-06-26" version="1">MAKTHRLMLSIEVFQVLLEHLNINGDQSRQTCERENVTRLYRVSHFELDVDADDDDEDDVDVDDDDDDGDGAVRRTKTGPRGGYLIPIASGKRQMQPFSVAASVSPVSAPFRARAMKMQQI</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">SETTUDRAFT_173420</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="19401248"/>
    <dbReference type="HOGENOM" id="CLU_2777532_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="69" mass="7612" checksum="8574124BC9F4EA57" modified="2013-06-26" version="1">MKIKAHGPTHRISASAKNTLHLSSISPQYVGPSKKPKLETSSSFDTEDFPIIDEHVLVLKILTRLKVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4N6</accession>
    <name>R0K4N6_EXST2</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_163429</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027131.1">
        <property type="nucleotide sequence ID" value="XM_008028940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4N6"/>
    <dbReference type="GeneID" id="19398763"/>
    <dbReference type="HOGENOM" id="CLU_2374117_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="95" mass="10492" checksum="6AF286BADA5B4852" modified="2013-06-26" version="1">MPATLRIRSGPNVPRYGDGYAACATATTAARRTLDVPIATTTGAITGARYTRQILANEWPTSCHNSYGAPEFDFRRAFWLCRTDCLEFSVDAWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4S1</accession>
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        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
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    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_164770</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0K4S1"/>
    <dbReference type="GeneID" id="19399232"/>
    <dbReference type="eggNOG" id="KOG2848">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_027938_10_0_1"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
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        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="112"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA83347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="311" mass="34192" checksum="B7CDF8977EE6CBB8" modified="2013-06-26" version="1">MSWLLYLAISPIVVIMAMRLLSLVLPARPAQLISFYAFAISSFILMGGCALYGTLVAIPLRMVGYGGLIQWTVARSFKWCMWLGTGVTFRVTGSMKKEAGVSGEDALNDRPAVFVGNHQTELDVLMLGCMFPKYTSVTAKKSLKYVPLLGWFMALSKTVFIDRANRTTSRAAFDTAAQTMKSTRQSVFIFPEGTRSYASKPDLLPFKKGAFHLAVQAQVPIVPVVCANYFHVLDVKGKRFSPGIIDVTVLPPIQTKGLGPEHVDELVKKARDAMMEELIRLSHVSGAGNGEPLPRSTGIDDQARSELRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K598</accession>
    <name>R0K598_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_164865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K598"/>
    <dbReference type="STRING" id="671987.R0K598"/>
    <dbReference type="GeneID" id="19399269"/>
    <dbReference type="eggNOG" id="KOG4563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028900_1_0_1"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="406"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
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            <begin position="306"/>
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        </location>
    </feature>
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            <begin position="17"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA83532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="458" mass="49893" checksum="FB362BA1C085850F" modified="2013-06-26" version="1">MADPATEPLATVTETEELPRTKEKLSELSQAASIHYSTKNFPAAAENYANAVEIQAELNGEMAPENAELLFYYGRALYKVAVAKSDVLGNKVAQEEKKNKQPKSKKAAKTETGEGSSTAAAKAEPKTESVQNKPYFQLTGDENWTDSEDEEDDDEGEQEEDDDDFGNAYEIFELARVLYEKQLNALAESDSADKGKGKAELSPAERVIKERIADCHGFLVEISLENERFHDAVADARKSLALQEELYPFEHENVTEAHYSLSLALEFASVSKVREDQTGQSTGAPDTEPGKEDEDGVNWELRKEAADQTDLAIKSLEARLKKEEDALDSDALKPDQKEKQAIIADKKSMLEDLKTRLVDLKSDPTKQQFDTIDSSVFQGLLGGMLGADPATQKAKLAEVAKTANDVSGMVKKKAKAPVAAASSASSASASKDSGSSKRKLEVEDSGADEKRAKTEEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7L9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_21014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026958.1">
        <property type="nucleotide sequence ID" value="XM_008028767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7L9"/>
    <dbReference type="GeneID" id="19402385"/>
    <dbReference type="HOGENOM" id="CLU_121091_0_0_1"/>
    <dbReference type="OrthoDB" id="3695114at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="152" mass="16576" checksum="BF2FFA8F3372677C" modified="2013-06-26" version="1">MEANAPNLNVEELAAYATTKSQAGVPDEEILREITQMLREDGWKEAAIGPTIEAVVKRSSVVGGKGSPRQEGSPKANQNAVAQVMEQMMQLLSPMASRLEALERNQAEGRSESSPRVDTPPPPLTTVAEPAACKNKFPNLERFNRTRDNYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7Y1</accession>
    <name>R0K7Y1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative glutathione-dependent formaldehyde-activating enzyme</fullName>
            <ecNumber evidence="5">4.4.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S-(hydroxymethyl)glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_129823</name>
        <name evidence="7" type="ORF">SETTUDRAFT_152320</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
            <strain evidence="7">Et28A</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
            <strain evidence="7">Et28A</strain>
        </source>
    </reference>
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        <text evidence="5">Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-(hydroxymethyl)glutathione = glutathione + formaldehyde</text>
            <dbReference type="Rhea" id="RHEA:22488"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="4.4.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.22" evidence="5"/>
    <dbReference type="EMBL" id="KB908773">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024195.1">
        <property type="nucleotide sequence ID" value="XM_008026004.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027948.1">
        <property type="nucleotide sequence ID" value="XM_008029757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7Y1"/>
    <dbReference type="STRING" id="671987.R0K7Y1"/>
    <dbReference type="GeneID" id="19396095"/>
    <dbReference type="GeneID" id="19397177"/>
    <dbReference type="eggNOG" id="ENOG502SKH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090716_0_0_1"/>
    <dbReference type="OrthoDB" id="3446116at2759"/>
    <dbReference type="UniPathway" id="UPA00562">
        <property type="reaction ID" value="UER00621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051907">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00723">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014185">
        <property type="entry name" value="Formald_GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02820">
        <property type="entry name" value="formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003829">
        <property type="entry name" value="PRK05417.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033318">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA88113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="190" mass="20534" checksum="DBCF702EB595A3BE" modified="2013-06-26" version="1">MVSIHPAIDKGIKKGVPNFPGGKLYCHCASDKVEVTLSSNVAHNHACGCSKCWKPQGALFSVVGVVPRENVAVTANASKLHIIDASAAIQRNACKQCGVHLFGRIETEHPFKGLDFVHTELSNTSGWQEPQFAAFVSSIIEQGFNPAGMEAVREKFRTVGLQTYDVLSPQLMDLIATYTAQKSGRLPAKL</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008029726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K815"/>
    <dbReference type="STRING" id="671987.R0K815"/>
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    <dbReference type="eggNOG" id="ENOG502SNM9">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5176208at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344268" evidence="1">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="176" mass="18948" checksum="2F42D9B1DCBBD3C3" modified="2013-06-26" version="1">MKLLSLITSASIVGIAASVDMSRYSARSGVDAGFQSFLKQLYASAEDPSSTTTFTNFFTRNGKLVVLRNTAVGSRQIIALKQELLPVAGNKHWNHLPNVTTVSSETSTMKTYQVLGVIETTFDRGNCSQAYYSTRFTVTKDASGSPHLIAHSGSLVAYDDYVVQPSKSPTNIPCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA65</accession>
    <name>R0KA65_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_117664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
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    <keyword evidence="8" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
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            <begin position="410"/>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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    </evidence>
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    </evidence>
    <sequence length="420" mass="47761" checksum="982E1EF17A8AACF0" modified="2013-06-26" version="1">MLLRIALFVVVACLALLVVGAEDYYKLLGLKKDASEREIKKAYRTLSKKFHPDKNPGDDTANQKFVEIAEAYEVLIEKETRKIYDQYGHEGIQQHKQGGGPRQQHDPFDLFSRFFGGSGHFGHQGGERRGPNMEVRVAVPLRDFYNGRKTEFTIEKQAICSACEGSGSEDGHVETCGACGGRGIRIQRQQLAPGLFQQVQVHCDQCHGKGKTIKSPCPVCNGNRVIREAETHKLEIEKGMPNGVRVTYENEADESPDYVAGDLIVHLAESEPAMGQQEHERTDGTFFRRRGQHLFWREVLSLREAWMGDWTRNITHLDGHIVQLSRKRGEVVQPGLVEIVKEEGMPIWHQQLDNNEGLQFGDLHVEYVVVLPDQMEKGMEKDFWSVWEKYRKKNGVSMDAEFGRPQEPIKMPEPDAHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KB39</accession>
    <name>R0KB39_EXST2</name>
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            <fullName evidence="9">Beta-mannosidase B</fullName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_155010</name>
    </gene>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09215">
        <property type="entry name" value="Thaumatin-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="14">
        <location>
            <begin position="430"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="12">
        <location>
            <begin position="612"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="13">
        <location>
            <begin position="1093"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA85467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1253" mass="140466" checksum="73C4144F5EB5CA8B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBE1</accession>
    <name>R0KBE1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="10">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cnxG</name>
        <name evidence="14" type="ORF">SETTUDRAFT_134971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025318.1">
        <property type="nucleotide sequence ID" value="XM_008027127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBE1"/>
    <dbReference type="STRING" id="671987.R0KBE1"/>
    <dbReference type="GeneID" id="19396283"/>
    <dbReference type="eggNOG" id="ENOG502QRSG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006524_0_2_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="13">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="786"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="829"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="834"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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    </comment>
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        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
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        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA87469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="480" mass="51348" checksum="C6BA38E9CDB4E0F0" modified="2013-06-26" version="1">MAAPFETRLFINGQYVAAKSSERLKIYNPTDDSLVTDDVHVAGQEDVDAAVAAARAAFPAWAATPAGERAAILYKFADLIEANTEAIGALNTMCSGQIKLMTSRFEPKLGARYLRYYAGWCDKLLGEVNPSSDGIMSIITHEPLGVCAAICPFNAPLQTICIKTAPALAAGNTVILKSSEKTPLSALLVARLAKEAGFPNGVFNVISGAGSTGALLASHMDINKVSFTGSSATGRKIAQMAAQSNLKRVQLELGGKSPAIIFPDADLAVAVEWCIRGFTTISGQACITTSRLYVHKSIREQFLAALKEGLKQVEAALGDPSKDNVLFGPLVDKIQFERVKAFLESGKQEATLAYGGEQVGTQGCFIRPTIFVDSKPDAKIYKQEIFGPVTVVNDFEDEDEVIGRANDTEFGLSGAVFSQDINRALRVASRIHSGTVCVNCSMQNQVEVPFGGVKSSGWGRENGKNGIMAYTEPKTTFIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KET5</accession>
    <name>R0KET5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_178654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025264.1">
        <property type="nucleotide sequence ID" value="XM_008027073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KET5"/>
    <dbReference type="GeneID" id="19401626"/>
    <dbReference type="HOGENOM" id="CLU_052827_4_2_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="226" mass="25244" checksum="B50A3B34C891309A" modified="2013-06-26" version="1">MSEDRIEDLTTLPWCRALLHDPSVTIINKRNVLKEDPSGANVNTFLNRTLWGDDRIRALVTLFRPGNGERRQGDPTKLDIQPDSAMWDVPPHKLEQEAQRQAKKEEKIFDVTDPNAPEAIFLVSVGDNVNGGPYRLHGGILSTLLDHCMGILCAFVYNSRAPPTVELTVKFKKAFKTPGVFALRSKIKREKGRFLETVGWIEDGEGNVYAEATAAYVISKVEAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFU2</accession>
    <name>R0KFU2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_176777</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024227.1">
        <property type="nucleotide sequence ID" value="XM_008026036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFU2"/>
    <dbReference type="STRING" id="671987.R0KFU2"/>
    <dbReference type="GeneID" id="19401492"/>
    <dbReference type="eggNOG" id="KOG0347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_13_0_1"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
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        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA87297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008027551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGW9"/>
    <dbReference type="STRING" id="671987.R0KGW9"/>
    <dbReference type="GeneID" id="19395682"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="52"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="345"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA87297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="567" mass="61825" checksum="AE7507DAE29C168E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KH23</accession>
    <name>R0KH23_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_19896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024963.1">
        <property type="nucleotide sequence ID" value="XM_008026772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KH23"/>
    <dbReference type="STRING" id="671987.R0KH23"/>
    <dbReference type="GeneID" id="19402250"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_0_1"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcJ)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="164" mass="18362" checksum="B30051A69D7211A4" modified="2013-06-26" version="1">MAGSSRNASPIKRLMTELQTYQSNKNEVLYDLGPTDEDVMQWRAVMKGVPGTAYEDGCWLLSISIPASYPLAPPTVRFITPICHPNVDFKTGEICLDLLKTSWTPAYTISTTMTSIHQLLTSAEPDSPLNIDVAQLFRTGDEVGARSLIRWYTVSERYEWKSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0KI05</accession>
    <name>R0KI05_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_39420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024737.1">
        <property type="nucleotide sequence ID" value="XM_008026546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KI05"/>
    <dbReference type="GeneID" id="19404475"/>
    <dbReference type="HOGENOM" id="CLU_1533500_0_0_1"/>
    <dbReference type="OrthoDB" id="3746467at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="175" mass="19826" checksum="492C1A0032A35D52" modified="2013-06-26" version="1">MLIDISEEYYAWHEGAYSTLLNALLPHLHPMLGRHVYDLLGGIEDIAKGNMGACVRTKMSVGEFEDMFGGEAEAERYLTRPLTRSVEIYCVSGAVWDTGYKNVQSRAAYSEWQQRCVRVEREKGVRMCDVVEELRGVLKPEDFAQQEGNAEILLQWQMADLRATSANFGGINSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KI40</accession>
    <name>R0KI40_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_148432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KI40"/>
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    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_CS1"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
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    </dbReference>
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        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="236"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA88894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="373" mass="41143" checksum="3A2EC40CC6B435BC" modified="2013-06-26" version="1">MGGGPDVPSRDVASKEKDLVLCTLPWPEADASRVIKVLKETFNDVDVEYHFTKYLNGKAEPIHVPEESLHRAKYMATLFWLPPSPASLPSVKLIQFASAGVNNHANHPIYTDSDIPLCSANGVHGPQIAEWVVMMDLVHSHNYTALYDNQKQKIWDSSPTKSVSDRVGKRVGILGYGSIGRQVGRVAKALGMDVLAYTASPRTTPESKRDTGYIVPGTGDPDGAFPSAWYSGTDKEHVHEFLKQELDLLVIAVPLTKATTHLLSTAEFELLHKSNPRGTYIANIARGQIIDQKALVTALHSNQIRGAALDVTDPEPLPKDDVLWDAPNVLITPHCSSMTDVYIDRVFELLVENIKHQRSGAKLINEVDRKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJL2</accession>
    <name>R0KJL2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_26599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022884.1">
        <property type="nucleotide sequence ID" value="XM_008024693.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0KJL2"/>
    <dbReference type="GeneID" id="19403036"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247342_0_0_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="607"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1232"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1455"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1492"/>
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            <begin position="1583"/>
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        </location>
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        <location>
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            <end position="582"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1606"/>
            <end position="1615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA89374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1727" mass="191529" checksum="EB2C26DAC68C0489" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKM7</accession>
    <name>R0KKM7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_106952</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
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                <person name="Han J."/>
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            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA88762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1547" mass="172956" checksum="9845E1FD2AF58949" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLP2</accession>
    <name>R0KLP2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_106701</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023523.1">
        <property type="nucleotide sequence ID" value="XM_008025332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLP2"/>
    <dbReference type="STRING" id="671987.R0KLP2"/>
    <dbReference type="GeneID" id="19395190"/>
    <dbReference type="eggNOG" id="KOG1583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344427" description="dolichyl-phosphate-mannose--protein mannosyltransferase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="586"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="688"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="338"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EOA88872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1080" mass="121746" checksum="FB8C6862A67AE979" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KMR2</accession>
    <name>R0KMR2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-1,6-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Endo-1,6-beta-D-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Endo-1,6-beta-glucanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_159629</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="13"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023053.1">
        <property type="nucleotide sequence ID" value="XM_008024862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMR2"/>
    <dbReference type="STRING" id="671987.R0KMR2"/>
    <dbReference type="GeneID" id="19397956"/>
    <dbReference type="eggNOG" id="ENOG502RBRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_7_0_1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000269">
        <property type="entry name" value="Probable glucan endo-1,6-beta-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF39">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 17 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343364" description="glucan endo-1,6-beta-glucosidase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="19">
        <location>
            <begin position="102"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EOA89222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="453" mass="51825" checksum="FA6F55086B0526B3" modified="2013-06-26" version="1">MFGGSSLVTALLAASALAWTPKHRELAAFNRTSNSFSKRAHPLPSWKIRGVNLGGWLLSEPWMMSGEWSDMGCGGACSEFGCVRSLGQEQADIAFNAHYARWITPSMIEDIHNAGLNTIRIPIGYWSLRGIVDSSEHFPRMDLRYLDAVVEKAAELGMYVVMDLHGAPGAQKTKDPFTGQCLPVEYLPGFFTQRNYDRATRWLDWMTRRVHTNAAYRSSVGIIGVVNEPQTARDQGGMPQEEIDTLTQKYYPQALKAVRDAENDLGIAEDDRLHVQFMDTLWGAGNPRSDIPADTKIMFDDHNYIGGAVVAKNPDAKQADYMYYTCYEDDRLSDGDTPKMVQEWSLTVQNEYSSEFDWRLAQNEAFYKQWFIAQQALYEKTHGWIFWTWRTQLNDPRWDYSYLVYKKWVPTTVEDLDASAARDICTEYFGTQGMIAKTKRMTRRARKQRDTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KMR6</accession>
    <name>R0KMR6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_37751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022912.1">
        <property type="nucleotide sequence ID" value="XM_008024721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMR6"/>
    <dbReference type="STRING" id="671987.R0KMR6"/>
    <dbReference type="GeneID" id="19404289"/>
    <dbReference type="eggNOG" id="ENOG502S5J2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063075_1_0_1"/>
    <dbReference type="OrthoDB" id="5284712at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34607" checksum="F27C645251CF636E" modified="2013-06-26" version="1">MRIPQSYIQKCKVVAHCFQAIFVFIAACLTIAVMTKDGDIGGGTRYFFIMCFLSIPAIIYLTMVPMWSRAQRFASAYAFLALDVLYTILWFAAFVSVAVWNSEGITEGAKKAKIPDNDRNCSTFLYGDEAKCSVSKASVGIGVMVFIFFAITTAISGYYLHKFLREGVMPYQSSSQDPHYASGDSAYNNSKDAAWSTEIETAHGRDSSDSLDQRTEHGGNQQEDEYALLNSTETDEGRHPGRPLSWGEGRTAPPYADYSREDRGSIAAGVDALSPGGYDEYRKEAGASMGSRLSGMDRQPSHTGSGYSFSGGPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNY0</accession>
    <name>R0KNY0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_166681</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Grimwood J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Martin J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020098.1">
        <property type="nucleotide sequence ID" value="XM_008021907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSA5"/>
    <dbReference type="STRING" id="671987.R0KSA5"/>
    <dbReference type="GeneID" id="19402100"/>
    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034597_0_1_1"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="69"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA91869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="390" mass="44380" checksum="4A1C3CA90D630F48" modified="2013-06-26" version="1">MHDPFPFPRPESLVKYVEPVAEYLSLKTLPLHFHEVAFAFVLYDVTYRIISPAVSRLFFPRIYSSFNARTRLNWDVHIVSFVQSTLICALALWVMWTDSELNQMDSIERVHGYTGASGLIQAFAGGYFVWDLIITVQNIKIFGIGMLFHAISALCVFSLGFRPFVNYYACSFILYELSSPFLNIHWFCDKLNMTGSTVQLVNGIALLCTFFSCRLVWGTYQSFRVFADVYHIYTAGIVPQSDPELGKLSNDTLVGNAAFKNDLLRYSEGQSIPFWLIFAYLASNVILNGLNWFWFSKMIETIRKRFDPPLGTKKQTPEIKTASLNIPEDEKVLVEGIHVATPGVVEKEDEDYLNVSKSVELEKDASGRHLEVHQSEIRSRPNPQRAAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSH2</accession>
    <name>R0KSH2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_36242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021270.1">
        <property type="nucleotide sequence ID" value="XM_008023079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSH2"/>
    <dbReference type="STRING" id="671987.R0KSH2"/>
    <dbReference type="GeneID" id="19404104"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080880_0_0_1"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA90732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="144" mass="16276" checksum="CB36DB98F752C36A" modified="2013-06-26" version="1">MPDAENPKPKELDSQDTPSKATELSIEEFHERADHYLGELLQRLEEAQENDPAIEVDYSAGVLEVTLQQNTFVLNKQPPNKQIWYSSPISGPKRFDWVVSQEGMSEKEGCGIGDWVYLRDGSSLTEIIRKELGVDVSVDDEVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KST8</accession>
    <name>R0KST8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_166766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021583.1">
        <property type="nucleotide sequence ID" value="XM_008023392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KST8"/>
    <dbReference type="GeneID" id="19399917"/>
    <dbReference type="HOGENOM" id="CLU_1679034_0_0_1"/>
    <dbReference type="OrthoDB" id="3873085at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17118" checksum="CCB63D726880ED34" modified="2013-06-26" version="1">MSAPRSKEHLRLALEIRRNGLPAPVPCDYCFANNRQCVAMPEVDGKRLKCSECTRLGHPCVNMSWVDEDEQLLAQVISRLMRNKRILKQAEERAAKKTMCLANSLRAGGDDVDAQESLDCPAADALVGFSPVMWSTLGSLDALASPSNPGDALVFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTM6</accession>
    <name>R0KTM6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_36591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021321.1">
        <property type="nucleotide sequence ID" value="XM_008023130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTM6"/>
    <dbReference type="STRING" id="671987.R0KTM6"/>
    <dbReference type="GeneID" id="19404155"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_0_1"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="104"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="368" mass="40927" checksum="EDC15D0ADD1C756B" modified="2013-06-26" version="1">MSSPSPLQIIIGISDLIEGASGMVDHGFRIYTTEGRMVTEIPLLAKKQYGADRIMWHRQDLHSHLLKVAKDETRNGPPAVVRTVSRVVDCNCDTGTITLQNGDVLQADIVVGADGIHSALRSLVLGKEVKPIPTGSSCYRLMMSSRDIKQQAPEFAANINPEQPYTSMMIAHDCRLIMGPARNGELYSIVGLVPDEKMNEDPDKAQSWVTEGDSEKMLETFKDFPEWTRTVMKQAQSIGLWQLRDLDPLETWHRGRVILIGDAAHAMLPTQGQGASQAIEDAEALGAFFADLHGQPTSDQVAIKLKEVFEARYERASLIQKFSRDAAKPAMEKGSQEIKMRPDEFMDYNCMYKGAVEWSRVHVVKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>R0KUW8</accession>
    <name>R0KUW8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_162246</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020721.1">
        <property type="nucleotide sequence ID" value="XM_008022530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KUW8"/>
    <dbReference type="STRING" id="671987.R0KUW8"/>
    <dbReference type="GeneID" id="19398322"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
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        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="112"/>
            <end position="277"/>
        </location>
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        <location>
            <begin position="408"/>
            <end position="559"/>
        </location>
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        <location>
            <begin position="773"/>
            <end position="825"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="724"/>
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        <location>
            <begin position="949"/>
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        </location>
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        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
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        <location>
            <begin position="962"/>
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        <location>
            <begin position="992"/>
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        <location>
            <begin position="1021"/>
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        <location>
            <position position="1"/>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1032" mass="118467" checksum="FF0BB675E5EB35B3" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KVZ5</accession>
    <name>R0KVZ5_EXST2</name>
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        <recommendedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_178286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA91932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008022746.1"/>
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        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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        <property type="term" value="P:fatty acid metabolic process"/>
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        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="6PGD_dom2"/>
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    </dbReference>
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        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="196"/>
            <end position="262"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35702" checksum="FE2EDCCB890E32ED" modified="2013-06-26" version="1">MPHSTNSAPVQHVTVIGSGSIGASWAALFLAQGLTVTAFDINPAAEATLRKLVTNTLPVLQSLGLDKSASASPENIAFTTDLATALKDADFVQENGPERLDLKQKLFNDMAALVRPDTIIATSSSGLTCTSIQSGMDAASHPERIIVGHPFNPPHLIPLVEVVGGEKTAPETIERTLAFYTVIGKKAVHVKKEVVGHIANRLQAALMREMLHMVQNDICSISDIDNAMAYGLGLRWGIMGPNTLFHLAGGEQGAQHMADHLLGPLTTWWAQEDPVLDDDLRKKWVDGTMEAISERKFDDLVTQRDAELVKLLNLRKDWDGYAEERKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0I717</accession>
    <name>R0I717_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_44238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0I717"/>
    <dbReference type="GeneID" id="19404908"/>
    <dbReference type="eggNOG" id="KOG1079">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SET_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="485"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8C9</accession>
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        </recommendedName>
    </protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
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    <dbReference type="PANTHER" id="PTHR47782:SF14">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
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            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="73"/>
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    </feature>
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            <begin position="22"/>
            <end position="33"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA81785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="207" mass="22284" checksum="BAC311457A6C8B12" modified="2013-06-26" version="1">MPPRNNPLPAAVRLFNCTICDKGYPRQLDYENHLRSYDHNHRQRLADMKKLTASNDNESSNKPKQGLDMRSIDVENANKKPGVGSRFTKIGGAGGAAAAGSRFKKVGVAVGAKEGGNESVEAKKVEDSVKVEEKKQEPVAATTTTTTTIPVPQADAKEDTAMVEGTGESITWEEYDFTKPTGCDHRSCPGCKTDGIWSGEWVAVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IB44</accession>
    <name>R0IB44_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_140630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029622.1">
        <property type="nucleotide sequence ID" value="XM_008031431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IB44"/>
    <dbReference type="STRING" id="671987.R0IB44"/>
    <dbReference type="GeneID" id="19396568"/>
    <dbReference type="eggNOG" id="KOG4200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043048_0_0_1"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA82501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52053" checksum="D7257A580D465112" modified="2013-06-26" version="1">MDQIKQDDGEKDRERSIASVVIDSLLLPVRIATSPALLRTYLRTALLIITSTVLFGFAVVAYSSFYYAYIPVRGIVVPVYLQFDHGPVSLYGNAAGKLAKWPYGLANIPGLVHRQKYDVVVELDVPRSENNLNAGNWMVGLEFRGPSTVGQGVKHLLGWDEEWSVQDHSQGGVPGATAEKVVTEGTTSETPTVLARSRRPVLLTYRSRILEMIYRLTRLPLYLVGWHTESEHIEISMMESVMFEPGYRNIPSSLRLELRSRLPIEVYRASVHISARLEGIRWLMYRYWITGAIVGILAFWTMEMCVLLFTWGLFTLLFSNSLFAPDDNNNNNNDAHPKIKSENDHKMPKLEPAETDPETPYSDTSRTFPTLPSQRPLSYTSSSPPKIEPHSPALRDIPLREDAEADDEDDDFILEEPVPRTVEREGVFTDSGIGTSLESGVERGLARRRSARGTGTGRNGSGEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>R0IB80</accession>
    <name>R0IB80_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SETTUDRAFT_120907</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Vacuole membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029641.1">
        <property type="nucleotide sequence ID" value="XM_008031450.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IB80"/>
    <dbReference type="GeneID" id="19395833"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
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    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
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        </source>
    </evidence>
    <sequence length="108" mass="12120" checksum="018742F546687BD6" modified="2013-06-26" version="1">MAPYTNIYTRTLVIALKSPPIGKNTLQVSTLTSVYPCTVDRIYSRAIAVGFELNDLLIKILLHHVQDALKPSRPAKQAEVKEQILQQVRHDRYGREKSYANLASGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0ID89</accession>
    <name>R0ID89_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_164755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029074.1">
        <property type="nucleotide sequence ID" value="XM_008030883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ID89"/>
    <dbReference type="STRING" id="671987.R0ID89"/>
    <dbReference type="GeneID" id="19399228"/>
    <dbReference type="eggNOG" id="ENOG502S7VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799658_0_0_1"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA83330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="347" mass="38449" checksum="FC71BE4B875E1FD9" modified="2013-06-26" version="1">MSSSSTSTKAPPTSSSKSTPGRIMARRPNSSFSTSRAKAGCPSKPRRRTTTISCATSFESPEVNAIRPLFLPGTYKTLGRAKASQNGSDAPLTVHLKKDLTKHLMDHEGVLLLPEVMSHLYTRVEKGTFTNTASRVCWGILLPNMSPTPGQSITFEIKPKWLAQSPNAPPGAMRCRNCAMQVSVPKKRDTYICPLQVLHGNSEALRPWVHTTVMRQFGRDLPSQAVVSTMVEGILNYLTVGDGVELLRHLLQLQSTLDPRGVLCRPHHGSDLFDYNLRLAMTLRDCSLFIKISYNTRGMTGIESKLGDLDFKSAEKIVDWTDKERQLLRDDAYLAPNGPPCWIQNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IDU2</accession>
    <name>R0IDU2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_22015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028731.1">
        <property type="nucleotide sequence ID" value="XM_008030540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IDU2"/>
    <dbReference type="GeneID" id="19402501"/>
    <dbReference type="HOGENOM" id="CLU_1058323_0_0_1"/>
    <dbReference type="OrthoDB" id="3657881at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004352905" evidence="2">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="263" mass="27329" checksum="BE7F675F7DDBC93E" modified="2013-06-26" version="1">MEILTLTITLSGLILATLCSAVPPAMLPACTRSNNGLTVCGSSPSSRNDIFKCNNLAWDLLDSCTAPNSVCENGTCTLPSVSCGEDGETKCSTTTTTTTTTTTTTTTTIPAAAIPMLQPGKQQVLDSSSSSGSDMTPHRISPRDLSTSESDSDTLTTEGCKEGQLKCMAADAHGRSGAVYKCNSIGLWKMIQDCSQYESAATNTALAGAKAGAQPYNCGRCSDLSGKPSDMVLGVCTNAHPNDTGVKYLACNNQWCGLCMVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0IG95</accession>
    <name>R0IG95_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_92133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
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                <person name="Lindquist E."/>
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    <sequence length="333" mass="36278" checksum="7699B1F8D680A052" modified="2013-06-26" version="1">MYARSPSWFVLSSKATADISYEALLPTVILTALASVMVVLRWCSRVCSRSITIGPEDYCVTAAMVFSAGFTAVVGRGESEISRVLTESDWSTEFSIDLVLAQAILYHLASNLVKTSLILQYIRLFSHVPSIVCICYALFILVLGATAWGVFGNVFLCDPVQSYWEMTTAGTCMDKEQHFWSTSVIGIVLDVAIWVLPIPVIGQLKLPRRQKTGLLVVFGLGGVVCIVTIVRLVLVQDAMSHGQVTRCGSYAIIFSSIEINIAIICASLLVMKPLFARFLPYVVSEQPLSAAEDGRTCRALTGMHLLSAGIVCAAEKRERGGRNDTVIEMGSFS</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">28A</strain>
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        <property type="entry name" value="YidC/Oxa/ALB_C"/>
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        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
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        <property type="entry name" value="60KD_IMP"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="417"/>
        </location>
    </feature>
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        <location>
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        </location>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908781">
        <property type="protein sequence ID" value="EOA84415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGN4"/>
    <dbReference type="STRING" id="671987.R0IGN4"/>
    <dbReference type="eggNOG" id="ENOG502S6X3">
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="472" mass="52143" checksum="393A803681E9EA3D" modified="2013-06-26" version="1">MAADVLSPRSDSAQAGVNRTSLPPLVTSPPSKAKLERASSYMNKRLSTFSNTSNTHQSVRSRPQSTAFPIFHSSLPYSLVRDFAYDPLHPLFYGPLPEQPSDISTPASEHSRRLSDPPPVAWRNDRSGWSAASWDEKEGEQLPQTSYDGGPPYSEDEDISSPVVTSHHGARHKKHKSNIVNFDHTRGRRGYPEEQHRRTNLVPINGESSYFANDDAAHTPSSEYITYPPESSRLGLPEGASRRDSHFATTLPPRAYADAETVLQGPPYDSDDDMSEPEDYIYDDSRFSRDYQFTIASPDEEMHGKAVALFDFARENDNELPLVEGQVILVSYRHGQGWLVAQDPKTGESGLVPEEYVRLLRDIEGGWNGLVGAIQSQPELAPPEANNGPESLLSPISAGPEAKTPTQADHPQNYTPVISTFSTSHKDLEKYPTERLGTPTAADSGLFPRHKDSGTMEGLESTPEPLSQHQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPE7</accession>
    <name>R0IPE7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_162971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025415.1">
        <property type="nucleotide sequence ID" value="XM_008027224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPE7"/>
    <dbReference type="GeneID" id="19398610"/>
    <dbReference type="eggNOG" id="ENOG502T22I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717786_0_0_1"/>
    <dbReference type="OrthoDB" id="3775616at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="391" mass="43933" checksum="C05D0222E21AEDB0" modified="2013-06-26" version="1">MTSQPLKHHTPANQSRPSCEAQHGDLYRARHSRLLKRQRSPTPMCERRKKSRQDSAAGPAPSCLLLVALREYGLLENIVSCLCPGDLLALLLCSKSIHEALVPQAGSLQNLLGKLRCSGKGVQIRKQRHVKSTFFYAYECSEYVECGATDGCAKSRPCANCKVTTCDECRIHCVYQSIFEKPCDDDELPNYSGFVLLSPSEIPILSPHHLADNAATPRWKAPSPGRSLPYHDQGFIDVPFDEENFGPPECVEEFLDLDLGKHTFAGSAVSNVAHPSPVLRALYDTTERRKRRFCDAHLPSDLLKHQDDLSPHWCRCSLRSRFLDRWLCLRCYENEETTISKTYPDHVAHCRCGSTKGRAICLWCRGEILQPHAQEPQPESETGPNLQDHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQI3</accession>
    <name>R0IQI3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_89345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025628.1">
        <property type="nucleotide sequence ID" value="XM_008027437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQI3"/>
    <dbReference type="STRING" id="671987.R0IQI3"/>
    <dbReference type="GeneID" id="19405773"/>
    <dbReference type="HOGENOM" id="CLU_108113_2_0_1"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="169" mass="18636" checksum="44B5FB075BEE396B" modified="2013-06-26" version="1">MAPNSADVDKLAESYMAGFLYISLCDYLALRAHGAPTSSRPPSLGSPAPQNNYGFAEHVKNNLHPILITRFPLAANEMHMNEAGKQVTIWTADQPEFKPEFVAALGNKELTYIADFVFVLDVNDESKMLRVLELIDILATDSFRVLVEKAYGISVSDKINGQEVHVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQW6</accession>
    <name>R0IQW6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_51272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025153.1">
        <property type="nucleotide sequence ID" value="XM_008026962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQW6"/>
    <dbReference type="STRING" id="671987.R0IQW6"/>
    <dbReference type="GeneID" id="19405180"/>
    <dbReference type="eggNOG" id="KOG3172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099537_1_0_1"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="116" mass="12662" checksum="6B0F747B075C2FBC" modified="2013-06-26" version="1" fragment="single">MTSTIGIPIKLLNEAAGHIVTLEITSGEVYRGKLIEAEDNMNVQLKDITVTARDGRVSHLEQVYIRGSHVRYFIVPDMLRNAPMFRSRGTRGRGVGLARGRATVNRARASTRGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQZ8</accession>
    <name>R0IQZ8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Septum-promoting GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_171503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025759.1">
        <property type="nucleotide sequence ID" value="XM_008027568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQZ8"/>
    <dbReference type="STRING" id="671987.R0IQZ8"/>
    <dbReference type="GeneID" id="19401105"/>
    <dbReference type="eggNOG" id="KOG1673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_0_0_1"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA87320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41112" checksum="390DB917826BED5C" modified="2013-06-26" version="1">MEESSSQAPVLDAHPAHLDGHAELPHPDLLPPEPVTVDAHEAQKHMDQTMDGPDDSMASTITANTVTPLPDVGQTSSLNNSPSPYTNDPHRPSTSYSDTAYQYTTHNGSRFATSSDADTPPRHGYYDNRDAHIGQSHSRPSSQMGRYSTSEGGARSNSYQEQQRSAQQQQQQDAVKNASVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLVGTKYDHFVNFPREEQEEISNQAKRFARAMKASLIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEIENIGEPLLLYQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0IUE4</accession>
    <name>R0IUE4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_107644</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023852.1">
        <property type="nucleotide sequence ID" value="XM_008025661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IUE4"/>
    <dbReference type="STRING" id="671987.R0IUE4"/>
    <dbReference type="GeneID" id="19395246"/>
    <dbReference type="eggNOG" id="ENOG502SMB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069197_0_0_1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="345" mass="39484" checksum="4A90C05CE4639734" modified="2013-06-26" version="1">MTDPTCALCGNPTSTKCGACESTTYSRYYCSKDCQVKDWPDHKTECKEHQILYLEKPLKRIAEIVQQAYYDFRMNTWDTPITRVVEGDSVLILQDELLRDEEKFFVKFPGHLTESERTKKTMLCSWIYKETTAWMYNLILGLVKGLDVKLEEATVDLGTISRMVTAFTPVGDRHDNWPDYFHNVLFVSSTKPKKKWVIDMAGAQYGIYNAFWDWTDYKTYYGVKVQAAYPFGTNRDLLKERAKARGNPFMTFGVVGIVAAQLDVAIEKWVESRGMSLAQMIALDEDAYEEAKKSLLESMDSAVSSYVATNDFDAEFKAAKDYERMNPGRSGIECQAIDAVFYKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>R0IWA9</accession>
    <name>R0IWA9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_183797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023660.1">
        <property type="nucleotide sequence ID" value="XM_008025469.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IWA9"/>
    <dbReference type="GeneID" id="19401994"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_20_1_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="8"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1507"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="613"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="432"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="763"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA89055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1632" mass="182562" checksum="7B210CAC6AF0DA7F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0IWN7</accession>
    <name>R0IWN7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-NAD kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_127652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
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        <text evidence="1">Belongs to the NAD kinase family.</text>
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        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
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        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
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        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0418">Kinase</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA89145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48209" checksum="29CC982761139798" modified="2013-06-26" version="1">MRVLQHRPLPWPRLLAVPAQKRAFSSTPRRRDIRSISELPLRTTPSYIQSPANTLLRLQWPSPLRNILVTKKKRTPNITESVVEFTSHIRSTYPAINVIFEPETADELHGQLPFPVYTYQKKNGIPRHLSDKTDLVCTLGGDGTLLRASSLFSHSENVPPVLSFAMGTIGFLGEFKFKEYKRAFREVYMSGAPDTYATLSDSLGKSPPSLPASPDDPLDRPLSYADIRGKAMGSNRTARILLRNRLKVGVFGPDGKRIGGAAEGDTYALNEVTLHRGSSPHLKIIDVYVNNRFLTEAVADGMIISSPTGSTAYSLSSGGSIVHPLVPAICLTPICPRSLSFRPLVLPAETPVTLRLGEKNRGREVEVSIDGNTITERLGTGMEVRIGGEEVKRDARGWEGGVPSIVRGTTGKEDMAEDHWVGGLNALLKFNYPFGDQDS</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="172" mass="18959" checksum="363BEC5048060EDC" modified="2013-06-26" version="1">MPPKKKVAASDGTEAEGGTFRWTLENERKLLVLIQGRYLTSEDYERLVTVFPGTNYNGVKIKVSRFRVEQRKLYDEYGWVLPEGGAKLRKTETPAKDNNSSSSTATPNKNKRSADDADTETPTKKPRARKSKQKKEEETSASAAETETETENGLDGGGGGGGIKEEEVETQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYB0</accession>
    <name>R0IYB0_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_104351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008024492.1"/>
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    <dbReference type="AlphaFoldDB" id="R0IYB0"/>
    <dbReference type="STRING" id="671987.R0IYB0"/>
    <dbReference type="GeneID" id="19395041"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_046006_1_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="34"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="198" mass="22043" checksum="C942732B6C5F341A" modified="2013-06-26" version="1">MASNNPNFPAGPYESGKHLAPPPRPSSPATAGYSLNHFMMRIKDPKKSLEFYCDCLGMHVVFIFNAGPWTIYYLGGRDVDMKNIRQSQGLLELYHIPADASTPYASGNDYSKPGVGFGHIGFTVPDVAEATNRVKSFGFEVMKPLDEAKEDQMALPDEIVQGKHGEVVEGYKHIFKQLTFVKDPDGYWVELIPPAFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0W6</accession>
    <name>R0J0W6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_174792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0W6"/>
    <dbReference type="STRING" id="671987.R0J0W6"/>
    <dbReference type="GeneID" id="19401346"/>
    <dbReference type="eggNOG" id="ENOG502SJNU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="76"/>
            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA90590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="443" mass="48366" checksum="615F0E474BEDACAC" modified="2013-06-26" version="1">MVPPALSTRSSSESLYSNSSSVCSAPDRLPPAITGPMVWQGNELDPAEYVVQLSDGEIRDIRAAIIKFKLTGLARSEISAKTFDLGNPELANKLSSLSKDIHLGRGVVVLRGLDTAYLNDEEAVIAFVGVCSHICPERATDSYANQTLSHVLDATKKPVPAECRGIGLAGSKVTAAMDFHSDRFSGDVLALYVRNDGGPGAGGKQSVVSFARIYNELLQSDPEVLETLAEPDWPFELKKKDGAPYLEPGPILFFSQGKPICQLVKAPLLGTPNLPRDAQLPPLSARQHRALAAVERLAKQFSTQLDRQPGDIQLVHNLSVMHARSEYRGARRSKNSHSSSSSSSSSMRRMRSSSNKHIKETHDDDDEDAPSTRHLLRMFLRDPTHAWAKPHTTSTTADLRAPDTTASTTKNSFDDPFEPGRPQNLPVFDTDPWRIISGRESHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0J135</accession>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_159073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008024127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J135"/>
    <dbReference type="STRING" id="671987.R0J135"/>
    <dbReference type="GeneID" id="19397898"/>
    <dbReference type="eggNOG" id="ENOG502SNG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024401_0_0_1"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
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    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="437"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="573" mass="64215" checksum="CCF066B5A9349164" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4X8</accession>
    <name>R0J4X8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
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        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_40870</name>
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    <organism evidence="14 15">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031390.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_CS_CYS"/>
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        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="487"/>
        </location>
    </feature>
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        <location>
            <position position="253"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA82443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="503" mass="53751" checksum="BA60CF595916D261" modified="2013-06-26" version="1">MSLPYAPRAAYYDGKIQPASSSSTFDTIDPATAQSLATVHATTAAGVDAAVASAQKAFPAWSATPPIERARILQRAVALLRARNDELAKIETSDTGKPFSETSTVDIATGADVLEFYANLVGGGGMNGETTMLRPDAWVYTSKNSLGVCAGIGAWNYPIQIALWKSAPCLAAGNCMVYKPSEFTPLHSTVLAEIYAEAGVPSGVFNVVQGAGDVGGYLTKHPGIAKVSFTGQVATGKKVAGSAANEMKYVTMELGGKSAFIVLPDADVDQAADGAILANFFSTGQVCTNGTRVFVPESLKAEFEKRVLDKMQYIRSGDLHNLNTNFGPLVSKPHYDKVMSYMKHGIESDKAKLLYGGLEKPAWLSSYSDKAYHNGYWVQPTVFTDCTDDMKIVQEEIFGPVMSILSYKTVEEVIQRANNTPLGLAAGVFTKDINMAHKVIARLDAGITWINTWGESPAEMPVGGWKQSGVGVENGKKGLEAWVRNKSTVVEMGGVVPTVFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNR6</accession>
    <name>R0JNR6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Utp21-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_43668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029507.1">
        <property type="nucleotide sequence ID" value="XM_008031316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNR6"/>
    <dbReference type="STRING" id="671987.R0JNR6"/>
    <dbReference type="GeneID" id="19404866"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002774_1_0_1"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="67"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="841"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="901"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008030242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JSD5"/>
    <dbReference type="STRING" id="671987.R0JSD5"/>
    <dbReference type="GeneID" id="19406032"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_5_1"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
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        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
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        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343616" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="36"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="263" mass="26684" checksum="4CCEF992BFDBC40B" modified="2013-06-26" version="1">MRFESILAAALPALVLAAPTPQDPDFTWDDTPEDSIVGGTAASAGEFPFIASLQVSGRHICGGTLINSNTIVTASHCSVRDVIGSPSNLRVRVGSLSTTSGGTLVGVSAVYTHPNYNAATYDYDVAIWKLSTPVSAGGNIAFASLPASGSDPASGATSTVAGWGATREGGSGSASLLKVSVPVVARATCQASYPQETISTRMFCAGVTSGGRDSCQGDSGGPIVNSAKGFIGVVSWGYGCARPNLPGVYARVSALLPFIQQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0JT28</accession>
    <name>R0JT28_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_58023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031316.1">
        <property type="nucleotide sequence ID" value="XM_008033125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JT28"/>
    <dbReference type="STRING" id="671987.R0JT28"/>
    <dbReference type="GeneID" id="19405232"/>
    <dbReference type="eggNOG" id="ENOG502SMK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_25_4_1"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA80669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="267" mass="29620" checksum="1D0878B9A4769A4A" modified="2013-06-26" version="1" fragment="single">TRGPGVVVAAAILTACIFATVGLRVYTRLRVQKWFGPDDIFAILAFFTTLGFNVVTIVGHAKYGWDRHSWDIPIDLISTSIALSPASKLLFSCCASCTRMSFLFLYHRLIKTLDMRRFQMFLYAAMALVVAIFVAAFFCIFLLCSPARAYWTFPPIPGSKCVKELPVQLTMGSLHTIADLVVTILPIPIIMRLPLSRSERLGALSMLSLGFAITTAGCVRIYDSWYASTGNHDLAWDTWFVWIAALAEVNFGLICCCAPTIRVLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUR7</accession>
    <name>R0JUR7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_165773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030765.1">
        <property type="nucleotide sequence ID" value="XM_008032574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JUR7"/>
    <dbReference type="GeneID" id="19399586"/>
    <dbReference type="eggNOG" id="ENOG502S6NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136890_0_0_1"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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            <strain evidence="4">28A</strain>
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            <begin position="90"/>
            <end position="99"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="179" mass="20537" checksum="F0C3D1EC1752A9F2" modified="2013-06-26" version="1">MTFRCKRCEKKNLRCFVDTASGQCAGCIAVKAECSLFVTEEEWEKVEAEKRQKRLELARSEEQTARLRRELLEVEERERAYADRDHAILNLQNREKEEAEGSSAPGMEFPATEPSLPVQSTDPGWLQADYSSSSFDPLPLDYFLSYENPILASVDFSDGTHVLDFLDYVLVVFELDIFH</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908637">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028360.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19404576"/>
    <dbReference type="HOGENOM" id="CLU_2016638_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="123" mass="14273" checksum="176017AA51CB0096" modified="2013-06-26" version="1">MQDNILNKIRGLLSKTNATSVVQAEFLDKDGRRQYLTKLRQLLFAITIRRYHDTTLFLDNDQNRQIKPLLNPILSGERLKYEDACLEICNYDFNTIQQALKSIVDQDTPNKDINSLIPKSTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0JY80</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">SETTUDRAFT_36055</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA81182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="127" mass="13612" checksum="24707ED84A61C2B3" modified="2013-06-26" version="1">MDIADDADELRCSSATSSTATTATKNDHCQNSNSGMAVAVAVAPVAVQHCHCPMPTRPHQEYEHGRPKGGGDVTYGSDGTGRVRDKKKGPRFILWLLLLSCSSAVSVWHMCLSSDLPFRLAHTSCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYI0</accession>
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            <fullName evidence="11">Kynurenine 3-monooxygenase</fullName>
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            <fullName evidence="11">Biosynthesis of nicotinic acid protein 4</fullName>
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        <alternativeName>
            <fullName evidence="11">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BNA4</name>
        <name evidence="14" type="ORF">SETTUDRAFT_165798</name>
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="11"/>
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    <dbReference type="OrthoDB" id="10053569at2759"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="4"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA81292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="482" mass="54815" checksum="65349EBDCD44B72F" modified="2013-06-26" version="1">MTQKVVVVGAGPVGSLAALYAAVRGFEVQVYELRADLRDPDTIPLNFSKSINLALSERGIHSLRQTGLSNLADAVLAETFPMHGRMIHVRKNGEYVRQPQIYDARGRSLLAMDRTGLNKALLDQLEAMPNVKLMFNHKLVGADFRKKIAWFEHRPKSAEEQGDEFEITFDLMIGADGAHSAVRYHLMKFVPMYFKQEYIDKLWCQFHVPPAPDGEFRIPSHYLHIWPQDESMFIALPNLDKTFTATLFLTRKGFEELDESGKVVEYFDKKFPGVVPDLITEDDLRKQYASNQHLPLISIKCTPYHYGNSGVIVGDAAHAMVPFYGQGMNAGLEDVRVLFDLIDKHPNDRSKALSEYTKERTPDAHTINDLALGNYREMASDVKKPLYLLRKWIEEQLYIYIPSAGWATQYSRVTFSNVRYSEVQRLAHHQAKILNRVVGLGFVSALVSALWFVRSGRAQRAKMRILLLISVVAQKLQSLMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYY4</accession>
    <name>R0JYY4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_151614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026360.1">
        <property type="nucleotide sequence ID" value="XM_008028169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYY4"/>
    <dbReference type="STRING" id="671987.R0JYY4"/>
    <dbReference type="GeneID" id="19397130"/>
    <dbReference type="eggNOG" id="ENOG502SHQF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA86093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="318" mass="35259" checksum="FAAC97F001F7A947" modified="2013-06-26" version="1">MLTAIVTTVLQVLQVKAGNGKHSMFVDYPKGVDRILKFLFASIISYNTSLTSTKISILLQYRRIFAVRELRIPLNVVMSICVVWGLVTVVSSIFACVPVSAYWHILERPKAKCVDEKIMWYTNAAVNIFTDLLLAFLPVRVIGNLHIARRQKIALVGILTIGWFVCVVSVLRLHALIRLQGHMTDNTYYSAPAAYWSNIEMNLAIVCASLPALKPLIVRIIPAFSSSHGGSNGYGSRFTSGGHTKRTETGHGVSSTARHTRDDGIELERSPGTPAPDKGSDGESLGKNIYVSRHFEQHYEDCSRTSDSESQKDLVQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZ60</accession>
    <name>R0JZ60_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_177377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
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        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82072.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="376" mass="41332" checksum="0004BA812589A568" modified="2013-06-26" version="1" fragment="single">MSSPLTVRNLTSTAISLLRVERFEDPNTLQSKANGYFFSSKTTTHATPTAPELSGHAQSFNCQDLEVILQPFESYTLSFPSLAQPSSTATLSSPTLRITIQTANNERHRVDTNPSYTQKSTQTFTALSASPSTTYKAIFHPSKPTPHLAIHSNHVPRYSSWMATLPDNLPVSAISIPGAHNAHTHYCALPSVRCQVHDIQTQLDNGIRFLDIRVQPVHATDVSKKELYLVHGAFPVSLTGPKYFDPVLQTCYTFLAANPRETILLSLKREGIGSATDDHLARILQKHYIARNPAAWYTQNKIPYLGSVRGKLVLVRRYTVESSTSTSTSDSPDVQNAGLDATAWPHNATHAVFPSSSSSSSSQCITPTFCLQDFCE</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </feature>
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        <location>
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            <end position="216"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22041"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA82282.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="243" mass="27765" checksum="B55D1263B5B9CDC3" modified="2013-06-26" version="1">MSSNKVVLYDLPSKQGVSWSLNPWKTRMVLNFKKIDYETDWVEYPDLAPRWKALGIPPNDKNDPGYFADYSSPVIRYADGSYQMDSWLIAHALEKQYPTPSLHLDDPVVLQIRDHVAAMTKPLVPLAISQVPVVLLNKPSADFFYETREKAFGKPLEQVRSEADEEKCWEEAAAAAKVTGDLLRKNGGPFFLGETVSYADFIFVSMVHFLRCIDEKIFQRYVALDETFPKVYAACEQWLGKKD</sequence>
</entry>
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    </protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
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    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
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            <end position="122"/>
        </location>
    </feature>
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        <location>
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            <end position="446"/>
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    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
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    </feature>
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        <location>
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    <feature type="repeat" description="ANK" evidence="2">
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    </feature>
    <feature type="repeat" description="ANK" evidence="2">
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA87453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_008024978.1">
        <property type="nucleotide sequence ID" value="XM_008026787.1"/>
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    <dbReference type="AlphaFoldDB" id="R0K2U2"/>
    <dbReference type="STRING" id="671987.R0K2U2"/>
    <dbReference type="GeneID" id="19402265"/>
    <dbReference type="eggNOG" id="KOG3171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1205403_0_0_1"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26035" checksum="77B676DD95CE8F02" modified="2013-06-26" version="1">MNPSAPSPAQDEFNELFRDKHTDARHPEDGRPDSDVSDPESPGAAADYLEKIDTDDELDLPADMRANYYMPSLRSEANTGPKGVIADAQAFEQAKKQARRFTWKKNSPPPQYTVKAYHDDKTGSSDDDEDAGFMRQWREARLKELQTVGDKMRSRTNSPSRKIYGTMPLVDGEGYLDAVDKTTVIACTRLILRRLHMHMHTNQLYSYQASARMGAALRCRIPSLFICIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_161067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024759.1">
        <property type="nucleotide sequence ID" value="XM_008026568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K331"/>
    <dbReference type="STRING" id="671987.R0K331"/>
    <dbReference type="GeneID" id="19398107"/>
    <dbReference type="eggNOG" id="ENOG502QV8M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030352_0_0_1"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="51250" checksum="ABD5A2A6CBC6C538" modified="2013-06-26" version="1">MSIRALRDAENVFRVEKRCKLCEQAPLSCEGIKCPANQVCVQNSRTCDDCASVNCQIDPTLGPAPASKPNVGAIAGGVIGGVAFVAIVTFIVWKYCLKGKRRPVEEQPEWHDVDMAPQEKDTDFQSQRSARASTHTVASMASSVLTRASNIIQIAYIPGVTNRSGPGSPDVLVPPVPPIPAMSPSSGTTTPYNDQHFFVPDFRDSVLSSNTLGRTSLAPSLAQRGSVASTVYRQNAIVSPLPAQTVVRGKAAVVSVKSAGSIGPADTPAQTPPVPQIDPKHAVKPIRIHMPGISPANSVRSIAQLGPVKALNITKKKSTEITTPKSSAGSASSSADTERTLVNPPELLVPHARPLTGASTISSDDGELHERARRGSLASDLDDDDNHARAQQSLLGKPAGKRDSELTEFQDTSPSPGSSPFSDSSSLEPPRPNMSQRITSYDTSLGLRAPMTPIVEESSASKRTSAVSKRDLSPFSDTNQSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0K537</accession>
    <name>R0K537_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_179293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027215.1">
        <property type="nucleotide sequence ID" value="XM_008029024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K537"/>
    <dbReference type="STRING" id="671987.R0K537"/>
    <dbReference type="GeneID" id="19401670"/>
    <dbReference type="eggNOG" id="KOG1443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_4_0_1"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="200"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Ciuffetti L.M."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="347" mass="38130" checksum="3F6C23CF0E81C63F" modified="2013-06-26" version="1">MAATASTSELKLDPKYDQYDFPTISPTAQNGHPGHTTPEQDAQVFQLRTALEQAGYTKNLDTLTLLRFLRARKFNVEASKQMFVDCEKWRSEYAGCGVEELVRTFDYTERPEVFKFYPQYYHKTDKDGRPLYIEQLGNVDLPALQKITSQERMIQNLVCEYEKMADPRLPACSRKSGYLLETSCTIMDLKGVGLGKAASVYGYLGAVSAISQNYYPERLGKMYVINAPWGFSGVFSVVKKFLDPVTSAKIHVLGSGYQKELLAQVPAENLPKEFGGTCQCEKGCSLSDAGPWWDPQWAREPKWAKKSEGDAINNAALPAPTEAGAGGAPAPAPAGTEPATAPAPATT</sequence>
</entry>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        </location>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="299" mass="30471" checksum="56468CCFD00973D0" modified="2013-06-26" version="1">MQWVLMSLASALSVSVASASFDPVSNAALQLHPRASRFSSGKLENAAANPPVEHKGTTVKFSSRSLGYLLPRQQTLVIRDVAATNAARAMDTAELSSRQYCGLIVGCQPDFGRCGDAVPEPSPTPTSTPSPTSPPLPPISSSVLPPLPSGTLIPSTNGQCGNVTTCTGSAFGGCCSEYYYCGNTLGFCGTGCRPAFGTCGGIALPPGSSSVPIPAPSSSTRPSTTSRPISTPTPSPTSSAAPVPTNVSTNGRCGADGNGQTCTGSSFGRCCSSYGWCGNGQDDYCRLSWGCQPQFGSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Scott J.A."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR13900:SF0">
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        <location>
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            <end position="903"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="similarity">
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    <sequence length="188" mass="20492" checksum="B591EB4170EDA9A9" modified="2013-06-26" version="1">MAFGSVTRILVGLLSTSSFSSVQIPDGLSIDDATRQYLEFLSAEKLVKILAIFQQAMGGQVPALPEVIEAQQLYWSYDRSPSFYSIPHATVLDDWADAYQQASAVVDQMTIEEKVFVVSGQTSTKIGYAGQIPGVPCLRFPGICGNDGPSGLMTSLVLTAILLPLLLVRHGTKRWPLNVVNSWAWSLK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
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        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="127"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="280"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA90188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="362" mass="38291" checksum="86AD122256D95950" modified="2013-06-26" version="1">MSTEEPQPGQDAGRVNDQLDRLNMDGEGEVIPRTEEEYAEAQLTLRAIVSSKEAGVIIGKAGKNVADLRDETGVRAGVSKVVQGVHDRVLSVTGSLSGISKAYGLAAKGLLEGAPAMGMGGVIRTDGTHPIRLLISHNQMGTIIGRQGLKIKQIQDASGVRMVAQKEMLPQSTERIVEVQGSPAGIEKAVWEIGKCLIDDHERGYGTVLYNPAVRVQPGVGPGPLSNGGSAPSGGMGGRSYNRTGHGADFSDAPPAFSRRSGSDAASRPPPPTHTEDGEEMQTQNISIPSDMVGCIIGRGGSKISEIRKTSNARISIAKAPHDDTGERMFTITGSASANEKALYLLYENLEAEKMRRSQAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBZ7</accession>
    <name>R0KBZ7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_115527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025479.1">
        <property type="nucleotide sequence ID" value="XM_008027288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBZ7"/>
    <dbReference type="STRING" id="671987.R0KBZ7"/>
    <dbReference type="GeneID" id="19395653"/>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_3_2_1"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="748"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="789"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA86924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="846" mass="93790" checksum="BB7F4A46D3DB1F73" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KC99</accession>
    <name>R0KC99_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_115723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025545.1">
        <property type="nucleotide sequence ID" value="XM_008027354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KC99"/>
    <dbReference type="STRING" id="671987.R0KC99"/>
    <dbReference type="GeneID" id="19395661"/>
    <dbReference type="eggNOG" id="KOG1533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_1_1"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        </location>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA86387.1"/>
        </source>
    </evidence>
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        <source>
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    <sequence length="392" mass="41580" checksum="7678267C8F01B14D" modified="2013-06-26" version="1">MVSSRPVASSSRQRPDESWIDIASGPSSTSLSSVADEIITTGLTVQHDSRLHRRQNRRSRGGGQFSVGTGHRVAAAGGNSSQEEYEESESESDRVMTSSNEAVGPSLLKHEFPSPSPQSVASSETLSEREDDEEDENATAVNYPRSSRREFQPRPNAFSHPNSQQAIRSHSGTLYTPRRAARPAGQRQSSYPQHTPFNAVAPNYQPDHDEALRASLSTLLSAAAAVRGLPKPGQPRTAPPSSTRVDPSSLRMVPESVALGNIAEETTSSPRSVSSGPSEKPKRKANAPLASARSSSKDRRAVRKVRKTGPLIEEISPTLLTWVVSAGVVVLVSAIGFSAGYVVGKEAGHAEAMGQLSGADAGRCGKEAASGMRSTGLGLRKLRWGSGAGIRV</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="104" mass="11259" checksum="1DFCAB5830EED389" modified="2013-06-26" version="1">MYNSHLSALNLFLMRKTWKAGVGWKPCRLDSCRDVCIVINDAAPCPLLQGSEFDIDKAANVELKPQVVVVDSNDAASVPLGEGEEGPHIDLTRAQAQGLSQLPN</sequence>
</entry>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
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    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="ADH-like_C"/>
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        <property type="entry name" value="Ketoacyl_synth_AS"/>
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        <property type="entry name" value="Methyltransf_12"/>
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        <property type="entry name" value="PKS_KR"/>
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        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
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        <property type="entry name" value="PKS_PP-bd"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08659">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="12"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="953"/>
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        </location>
    </feature>
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        <location>
            <begin position="2504"/>
            <end position="2578"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="953"/>
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            <begin position="1117"/>
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        <location>
            <begin position="481"/>
            <end position="494"/>
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    </feature>
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            <position position="987"/>
        </location>
    </feature>
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            <position position="1188"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA87714.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2591" mass="284310" checksum="70706280D343E670" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>R0KEU5_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_39295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026366.1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_740022_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="210"/>
        </location>
    </feature>
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        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
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        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
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            <end position="113"/>
        </location>
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            <begin position="117"/>
            <end position="127"/>
        </location>
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        </location>
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            <begin position="240"/>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="374" mass="41854" checksum="ADCD0904C344E6EF" modified="2013-06-26" version="1">MSATPFQTPPPRQKPKRLPKKRKRPDTNALRAAAAQLDHINSLSAKFKVPAFVELLSDNDDGQESEDILEAEYQEDAKSKGIKMLKRRGGDKYSTPMHFQEFSATQASNMSESNRARLPRKHARRHSFISYSSSESEGKLLIPSQPISKIPCSPFLQESPRPPRRHAAKAPRRAPKPPNPSTIQARSINSPSNSDTVHRPASKKRRTSSQKLLEEIQDLAIDMQGWDRSYTPDTKRITRSQRSATRQESSAPVQLARTARRTRFWLDSESPVRSRGGSSSADDTAAYGGTVKEEFEARSKTKEETGIYTEAFYMPQTSHCGIFSGPSSPADETLDAQLLQRITQRMRDPHDIIHAGCDIAMPSIEVEENEILGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0KF61</accession>
    <name>R0KF61_EXST2</name>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">SETTUDRAFT_133112</name>
    </gene>
    <organism evidence="28 29">
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        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">28A</strain>
        </source>
    </reference>
    <reference evidence="28 29" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020675.1">
        <property type="nucleotide sequence ID" value="XM_008022484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KF61"/>
    <dbReference type="STRING" id="671987.R0KF61"/>
    <dbReference type="GeneID" id="19396181"/>
    <dbReference type="eggNOG" id="KOG2333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_7_0_1"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="81"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EOA91483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="742" mass="82666" checksum="BBF508EE65C1C3D9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFU5</accession>
    <name>R0KFU5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_171274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025517.1">
        <property type="nucleotide sequence ID" value="XM_008027326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFU5"/>
    <dbReference type="STRING" id="671987.R0KFU5"/>
    <dbReference type="GeneID" id="19401088"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_51_3_1"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGA1</accession>
    <name>R0KGA1_EXST2</name>
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        <recommendedName>
            <fullName evidence="5">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_85211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91883.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="834" mass="93355" checksum="B53E9CAEE0564EC8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGC6</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_152936</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
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            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
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        <property type="protein sequence ID" value="EOA91913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGC6"/>
    <dbReference type="STRING" id="671987.R0KGC6"/>
    <dbReference type="GeneID" id="19397242"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_1"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="390"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA91913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="507" mass="55486" checksum="C0CF6429A5AB4E00" modified="2013-06-26" version="1">MLARHVPASTALSAAAHRALPAASAATRLSTAAPSNRTQKRTLATVQDAAPKRTYGGLKDQDRIFQNLYGHHGADLKSAMKYGDWYKTKEILLKGHDWIISEIKASGLRGRGGAGFPSGLKWSFMNFKDWDKDDKPRYLVVNADEGEPGTCKDREIMRKDPHKLIEGCLVAGRAMNATAAYIYIRGEFYHEATVLQRAIQEAYQAGLIGKNACGSGYDFDVYIHRGMGAYVCGEETSLIESLEGKPGKPRLKPPFPAAVGLFGCPSTVANVETIAVAPTICRRGGSWFASFGRERNQGTKLFAISGHVNHPCTVEEEMSIPLRELIDKHCGGVRGGWDNLKAVIPGGSSTPILPKHICDDQLMDFDALKDSQSGFGTAAVIVMDKSTDVVRAITRLAKFYHHESCGQCTPCREGSKWTHQIMDRFAKGQAREREIDMLQELTKQVEGHTICALGEAFAWPLQGLIRHFRPELEARINDYGLKHGGKALAGGWAHDAVKKGQLVSPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGR8</accession>
    <name>R0KGR8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_116036</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025685.1">
        <property type="nucleotide sequence ID" value="XM_008027494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGR8"/>
    <dbReference type="STRING" id="671987.R0KGR8"/>
    <dbReference type="GeneID" id="19395675"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="12">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA87227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="398" mass="43173" checksum="F143CC1753329760" modified="2013-06-26" version="1">MASAAPADIQGPSHPNPEGLNTSASTQFPPINIGTRNSVLAQIQARAVEASLKQAYPHRTYNICPVVVQGDRDKITPLQQLSQGENAKSLWTGELESMLEAGDLDIIVHCLKDMPTQLPEHLALGAILEREDPRDALLISPRLPKETTLATLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLGKLDAEDSPYQAIILAAAGLKRMGLENRITQYLSSTSGGMLHAVGQGALGIEIRKNDEAMKEIVSGVRCERTTRACSAERALLRTLEGGCSVPIGVETSWRGSKGLAVGTQPLKDYDKHGNAMEEEQPDIDDQELVLRAMVVSVDGKESVEFEAAHKVRNAQEAEEMGREVARALIEKGADKILEKINVEKQWTAKKQLEELKAKSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGV1</accession>
    <name>R0KGV1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_88653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
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                <person name="Lindquist E.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023621.1">
        <property type="nucleotide sequence ID" value="XM_008025430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KIF8"/>
    <dbReference type="STRING" id="671987.R0KIF8"/>
    <dbReference type="GeneID" id="19396987"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="13">
        <location>
            <begin position="283"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="538"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="16">
        <location>
            <begin position="774"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="637"/>
            <end position="639"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="644"/>
            <end position="650"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA89004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119414" checksum="5EA1E613D486A788" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJ24</accession>
    <name>R0KJ24_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_167725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023000.1">
        <property type="nucleotide sequence ID" value="XM_008024809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJ24"/>
    <dbReference type="STRING" id="671987.R0KJ24"/>
    <dbReference type="GeneID" id="19400281"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_5_2_1"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="58" mass="6478" checksum="0F9AFBE856C26ABF" modified="2013-06-26" version="1">MPDQPQKQSAGCLKRLSPSFARGTHKLYIKAEPMVLLCKCLDRWPTVSKASRICTGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKZ5</accession>
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            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">SETTUDRAFT_167575</name>
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    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022741.1">
        <property type="nucleotide sequence ID" value="XM_008024550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKZ5"/>
    <dbReference type="STRING" id="671987.R0KKZ5"/>
    <dbReference type="GeneID" id="19400227"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031771_1_1_1"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="296"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="436" mass="46725" checksum="EB97651507B4328D" modified="2013-06-26" version="1">MAPYDSDSSDGGDDYTETNVLLGYATKDTTSDAISHLGGAPSWIDDKTAPSGALAKCKVCNGLLSLLLELNGDMPDTFPGHERRLYIWTCRRKTCRRKEGSVRGIRGVRVAKGASNKMPAPKAEKKEEKQEEKPQPQIGESLFGVKNGTAAATSANPFSNPFSSKPNGNAASNPFSSQSASANPFGAPAPAPAVQTIASEENKDEAPTTLAETFASKARISLPPAEQQPPRPHEPWPAESAFPTPFPHYYLDAEYETLDVPSAPSIPANARMEIDNEGSGSGGGKEDKEIFESSMDRTFQKFADRVGENAEQVLRYEFKGKPLLYSDSDAIGKALAPHSENGASSNAKVTTAASRSGPGFPRCQTCGADRVFEVQLTPHAITELEADEMTLDGMEWGTIIMAVCSKDCKPNDVPEGEVGYVEESVGVQWEEVAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLJ3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_36669</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021863.1">
        <property type="nucleotide sequence ID" value="XM_008023672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLJ3"/>
    <dbReference type="GeneID" id="19404168"/>
    <dbReference type="HOGENOM" id="CLU_953641_0_0_1"/>
    <dbReference type="OrthoDB" id="3687185at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343348" evidence="2">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="292" mass="30285" checksum="BC062842E27A9A5A" modified="2013-06-26" version="1">MRASLLLLLLLCCGQHGATTTTTTTTTCAPPRQGHNHQRGFSAQITLAPCPGSCTCAAKGATLKQAERPVAPGTSSQSLISFVSPTSQGHVWQVSTGPLIPPANIEGCRPAAAAPATRTPSSLTLPAIYTPCSSLSLPVSLPLSLRLSLYPVPLPGQSTGAPRQSPPIVIPPRPWLLLQPPLPRPLSHTPPATTDNTDSGAPSRPFSPTTSTGRPFGDRSQTAFSPQSVRVAPPAPLPAPPATIVRQTANAHTAHGAPVTIMIFRESESNNMGRGAYDTTGTPKPTSPPQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KMJ5</accession>
    <name>R0KMJ5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_26361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022856.1">
        <property type="nucleotide sequence ID" value="XM_008024665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMJ5"/>
    <dbReference type="STRING" id="671987.R0KMJ5"/>
    <dbReference type="GeneID" id="19403008"/>
    <dbReference type="eggNOG" id="ENOG502S504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115063_1_0_1"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
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            <end position="32"/>
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        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA89142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="89" mass="9362" checksum="B4B67E71644431BB" modified="2013-06-26" version="1">MVKPVVSAMNAWTCIVVSLFAIVILSTIGSLFKGHSNTVMGGEEDPKDGAAVAGAVFGAVFIYIGFFVFCGLQALLHLRESRRGAISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPK4</accession>
    <name>R0KPK4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_25062</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008023038.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0KPK4"/>
    <dbReference type="GeneID" id="19402867"/>
    <dbReference type="eggNOG" id="KOG0158">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA90969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58238" checksum="D21D777FAF8DBCD7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQE9</accession>
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        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_170231</name>
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    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020551.1">
        <property type="nucleotide sequence ID" value="XM_008022360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQE9"/>
    <dbReference type="STRING" id="671987.R0KQE9"/>
    <dbReference type="GeneID" id="19401029"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="768"/>
        </location>
    </feature>
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        <location>
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            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
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        </location>
    </feature>
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            <end position="118"/>
        </location>
    </feature>
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            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="137"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="695"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="86368" checksum="41AAFC6B25ED05A6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KR77</accession>
    <name>R0KR77_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_162217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KR77"/>
    <dbReference type="STRING" id="671987.R0KR77"/>
    <dbReference type="GeneID" id="19398305"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040397_0_2_1"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="38"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="250" mass="27802" checksum="C6FADE6FEAC65EE6" modified="2013-06-26" version="1">MPIWDPLVPAERVIQRCLARLPPAISHWFGYRHKTLPPSRTWLVCVWGFIGAFCGLSTILAIFGHTDYFRSRAVPPIVASFGASAILCYGAIDVPLAQPRSLIFGHFFSGLVGVIIATIFQFNLENDPYPRLQWLAAALATAIALVVMHLTKTTHPPAGATALLPCIDQHIWALRWYFLPVLLLSSTIVLVTAMLLMNLQRQYPKFWVAQIPSAPPVEKKEDKETKKDVTEGSEASSARDTLQDMERGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KR82</accession>
    <name>R0KR82_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_162220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
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        </reaction>
    </comment>
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        <property type="protein sequence ID" value="EOA91514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KR82"/>
    <dbReference type="STRING" id="671987.R0KR82"/>
    <dbReference type="GeneID" id="19398307"/>
    <dbReference type="eggNOG" id="ENOG502RCTR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051214_1_1_1"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="79"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA91514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="343" mass="36333" checksum="DCB3E2457A9FB5CB" modified="2013-06-26" version="1">MDAKSAVPNPHTRSRRRKLLCIVLPIVAVCILALALGLGLGLGLGGGSDDNNGSGGNGSSTPLPSPNSTLPWVPAVAATWQIILSHPPDLSSALTPNVSVYDIDLFDTPADTIKQLHSLGIKVLCYFSAGSYENWRSDAKDFKDADLGKPLDGWPGEKWLNLNSENVRNIMKKRIDLAAQKGCDGVDPDNVDGYQNDNGLGLTSQDSISYMKFLSNITAPLNLALGLKNAGDIIPAVLPVVHFSVNEQCVQYGECDTFAPFIAAGKPVFHIEYPSGAGAQQGLKEDVLGGSCKRDGKGQGSQNFSTVLKRMELDGWVEYCDGKVEVTNIDQATGGGRGSASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRB1</accession>
    <name>R0KRB1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_167246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022215.1">
        <property type="nucleotide sequence ID" value="XM_008024024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KRB1"/>
    <dbReference type="GeneID" id="19400094"/>
    <dbReference type="eggNOG" id="ENOG502SV9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_6_0_1"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF33">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="266" mass="29726" checksum="23F798F31ED5D0AE" modified="2013-06-26" version="1">MPSTKSFPAITGGCVCNTVRYRLLTSPLFCHACHCLDCQRVSGSAFILSLEIELYNIKIISATLPAFTKHEPKPGVFEQFAECPKCRVRLWADSMVEEAVCDVRVGTLDFPSLMEPDLHIFVESKLDWVRLPDGARTMLKGGNVQQFWPKSSLKRLEICRQRVEEAKQRRAAALTGVKDAAKSGGEGGVEEVDGEGDKTPTALEFSREDDEEFEVRFREKEKALQDRLEKLSLKLGERKGSEMDQTSVQLAEPDPDKSRQDTGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0KT26</accession>
    <name>R0KT26_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_162602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021031.1">
        <property type="nucleotide sequence ID" value="XM_008022840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KT26"/>
    <dbReference type="STRING" id="671987.R0KT26"/>
    <dbReference type="GeneID" id="19398452"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020492_1_0_1"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA92099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="543" mass="61666" checksum="F1828FA994C61288" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KUN4</accession>
    <name>R0KUN4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_170389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020680.1">
        <property type="nucleotide sequence ID" value="XM_008022489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KUN4"/>
    <dbReference type="STRING" id="671987.R0KUN4"/>
    <dbReference type="GeneID" id="19401038"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_14_0_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA91492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="59988" checksum="335CCFC9DD2EBBF7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5G1</accession>
    <name>R0I5G1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="4">M1Pi</shortName>
            <shortName evidence="4">MTR-1-P isomerase</shortName>
            <ecNumber evidence="4">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRI1</name>
        <name evidence="5" type="ORF">SETTUDRAFT_166325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="4"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031489.1">
        <property type="nucleotide sequence ID" value="XM_008033298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I5G1"/>
    <dbReference type="STRING" id="671987.R0I5G1"/>
    <dbReference type="GeneID" id="19399771"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_3_1"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000010">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA80895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="392" mass="41495" checksum="44CD6C24FAEB2673" modified="2013-06-26" version="1">MVLQAIKYERGQLQILDQLKLPHAEEYDHIYSSTDAWHAIKDMRTRGAPAIAIVAALALAVELTNMKLAAVPEEVKVFITEKLDYLVTSRPTAVNLADAAGKLRKITEHAAAEAGATGETVREVYVTAAEQMLVDDVSDNESIGKHGAEWIVSNTEAGKKGPVSMLTHCNTGSLATAGYGTALGVIRSLHANGSLKHAFCSETRPYNQGSRLTAFELVHDKIPATLITDSMAAALLRLRGESENIAGIVVGADRVAANGDTANKIGTYSLAILARHHGVKFLVAAPRTTIDLNTKSGTDIVIEERPGKEVTLVKGPRHDGVSLDLGVVETISIAANGIGVWNPAFDVTPAELIDGIITEVGVVEKDSNGVFHLDKVFEAEGSGAKPSTVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6Z1</accession>
    <name>R0I6Z1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_122991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030842.1">
        <property type="nucleotide sequence ID" value="XM_008032651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I6Z1"/>
    <dbReference type="STRING" id="671987.R0I6Z1"/>
    <dbReference type="GeneID" id="19395903"/>
    <dbReference type="eggNOG" id="ENOG502QSI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059771_0_0_1"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="36887" checksum="3C9E51EE7361C69C" modified="2013-06-26" version="1">MPPSSRIPPLLQPYAELPREESLTLVTSTLGASANWLLIRFLCAALGTATARGGGEEDHNVVLVSWMRPYEFWKQESRKSAALDLERLRKEGRFAFVDGLGAGSDATSDARQASAAPSNGIHAQRGLQTLSARGPPGRIVPARGPPASPQATTTTAETTGASSNTSGHYTLKSLELDDVKATISSAVSALTTAPVQRKTLLIFDNPDLLLALNPSITPSRFTSLVLTLQTIPTVSHILTHIQSDNPLLSLSAPPQPLELAHHNLLVKCAHMSRRILGVRILDTGVARDVSGVIRITEQKHEWLDLGFGDNEPKEGGDSGRGKEFLYQVKGDGSVRVFERGAGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAF2</accession>
    <name>R0IAF2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_157133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030553.1">
        <property type="nucleotide sequence ID" value="XM_008032362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAF2"/>
    <dbReference type="GeneID" id="19397700"/>
    <dbReference type="eggNOG" id="ENOG502R8VP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067373_0_0_1"/>
    <dbReference type="OrthoDB" id="3718497at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="277" mass="32368" checksum="F07B168F5D01D4AB" modified="2013-06-26" version="1">MTHFTNRPGNNEHVLCRQKLETLPVEIVNRILCYLIHPRCRLPGLTEAQSGWEVSEKQKRSIKNQEDLTQSADTHRWAADIFSLRLVSHPFNALALTSRTCHALVEAYCAHLVRRCNRTMFNLPFAQLDMYGPNCVYPDLSSIVYRRLWLQHAPRMCVYCHATLDCYPFSRVNRLFTACEGCFYRQAMTIEEVQRQYHLSPTAIHTSHRIRGNPNSPWILRVDVEALALQLYRTRQFHDAHPEQFGKPCSMCAITRFTHRHDVKKSPPSQKYFMAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAV4</accession>
    <name>R0IAV4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_43411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029490.1">
        <property type="nucleotide sequence ID" value="XM_008031299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAV4"/>
    <dbReference type="STRING" id="671987.R0IAV4"/>
    <dbReference type="GeneID" id="19404849"/>
    <dbReference type="eggNOG" id="ENOG502QSSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:lactone biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="AdoMet_MTases"/>
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        <property type="entry name" value="enoyl_red"/>
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    </dbReference>
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        <property type="entry name" value="PKS"/>
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    </dbReference>
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        <property type="entry name" value="Polyketide synthase Pks12"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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        <property type="entry name" value="Polyketide synthase dehydratase"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ac_transferase_dom_sf"/>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="Acyl_transferase_dom"/>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
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        <property type="entry name" value="ADH-like_N"/>
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        <property type="entry name" value="ER"/>
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        <property type="entry name" value="GroES-like_sf"/>
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        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
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        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
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        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
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        <property type="entry name" value="PKS_DH"/>
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        <property type="entry name" value="PKS_DH_C"/>
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        <property type="entry name" value="PKS_KR"/>
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        <property type="entry name" value="PKS_mFAS_DH"/>
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        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
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    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="FATTY ACID SYNTHASE"/>
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        <property type="entry name" value="KAsynt_C_assoc"/>
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    </dbReference>
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        <property type="entry name" value="ketoacyl-synt"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Methyltransf_12"/>
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    </dbReference>
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        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
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        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="6"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="925"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2482"/>
            <end position="2563"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="925"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA83405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2567" mass="278803" checksum="51026AF8E16CD64E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0IEW8</accession>
    <name>R0IEW8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_164249</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028322.1">
        <property type="nucleotide sequence ID" value="XM_008030131.1"/>
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    <dbReference type="GeneID" id="19399058"/>
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    <dbReference type="HOGENOM" id="CLU_017633_0_3_1"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd06257">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000053">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="162"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="162"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA83845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="456" mass="47524" checksum="AB0864C4ED28E008" modified="2013-06-26" version="1">MVDPYETLGVSRDASAADIKKAYYGLAKKYHPDTNKDPGAKDKFAAAQSAYEILSDAEKKKAFDSYGAGAFDANGGFNPGAGAGPGGPGGNPFGGGFGGFGGFGGGAQGPFQDINFEDLFGAFTGGRRGRSGGRRSPFEEEIMVGDNIEVQTNISFLDAAKGVKKDIHVTPLVECGTCHGSGLKQGAKRAECKSCGGTGQRVTSMGSFHMSATCSSCGGSGFAIPRGSSCGTCGGDGAVKERKTITIEIPGGVEDGMRLRVNGEGDAPLTGQAMSSGQIRGQKGDLYVLIRVAADPKFKRSGSDILHTATIPLTTAVLGGEIKVPTLDGEVKVKVPTGSGTGDRITLPGMGMKVLSGRRGGKGDLRVEFKVNMPKYLSVNQRTILEMLADEMGDKSAQRVINPGKMKDTAGNTAPSGHENEGFLKSAWHNLTGQHRHMSAEERRQAEEDEKKKGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0IFT7</accession>
    <name>R0IFT7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_32927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028087.1">
        <property type="nucleotide sequence ID" value="XM_008029896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IFT7"/>
    <dbReference type="GeneID" id="19403715"/>
    <dbReference type="eggNOG" id="ENOG502SRKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051697_0_0_1"/>
    <dbReference type="OrthoDB" id="5378696at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="317" mass="36520" checksum="406266CF10413C0F" modified="2013-06-26" version="1">MEIESTVLLKEIKKNNLKQTLEDNKARLNKNDLNRKLAETNVVLRSKAGKSARALRMAKDERESLQTKIKNAEEELQKCRETEEEVQLERECEHSLAKAEDLRTSNDFYKRQDSNQTQTIFNLKRLVANLQKTERNEGYIKTITTHKAEIARLVANEVRLKDEVQKHQRIAIKALERMKEQIKIANEAKKEVATYKGHALAAKHSLLVSLSHTKFELAMEIVNNVFKGLKDIDSEEKAKQAIHSINGYLEQQSKTVEDYTTNVMSNSAEVRGVIQDLQGYTLKEARPNEFGSFIDYVRGLQHTLETEAKKWKNKLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJ39</accession>
    <name>R0IJ39_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_137572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027613.1">
        <property type="nucleotide sequence ID" value="XM_008029422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJ39"/>
    <dbReference type="STRING" id="671987.R0IJ39"/>
    <dbReference type="GeneID" id="19396420"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025343_0_0_1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA85145.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="12">Patatin</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">SETTUDRAFT_40223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">28A</strain>
        </source>
    </reference>
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        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="389"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="959" mass="106613" checksum="DFAA4950BF90C4AB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IL89</accession>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="671987.R0IL89"/>
    <dbReference type="GeneID" id="19395473"/>
    <dbReference type="eggNOG" id="ENOG502QS95">
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    <dbReference type="HOGENOM" id="CLU_005287_0_0_1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <dbReference type="GO" id="GO:0051286">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005519">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AIP3_C"/>
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    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
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    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
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    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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                <person name="Wu D."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Bushley K.E."/>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5565730at2759"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="243" mass="26883" checksum="333FB5F6C358710A" modified="2013-06-26" version="1">MNTKYDPAQVTHPLELAQHAALVGGASAIPGTVIGAFYGTLRTQTPILFSLASGAQWFALGTTFWGFRASILNHSGLLNWWNITRGAPIHPRNDLNPSSSDKVRASAIAGGSTGFTLGFLFRGPRNVIPGTLMFSTLGWLGQHGYNYLDDRHSGQLREEAELKARGEEKPKETLMDKIAKSKWSPMQVLTDEDYDKLMQEKLLRVEAEIAVIDDKIEALRKEAAQMEAQRQVKATQEQEKSSK</sequence>
</entry>
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    </gene>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA87925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LigB-like"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
    <sequence length="298" mass="33440" checksum="ADD5665F7AC26021" modified="2013-06-26" version="1">MTYSASEPESTSCSQTPVLFASHGTPFTYLNESPSTVWWQEFGREALAHGIKGIVYVCSHWVEEDDRIRVSTGEHPQVTHMELVPRRYWENYPINVSPELGRRVVSVLKAAGLPDVDEDPNAQWQDDTLTPSRWMFPEGNPPATCVSINARYDPIVHIKLGRALRPLRSEGILIVGSGAITHNLFRASWAPVLRSGLRTAYHPNYKPEKWVLDFERAVRDSIMFNSGPRLAGALVRLLDHPCYKLAHPSDDHFYPLIVIAGVVSGDDDTVHGRKMAESWDVGNVCSSQYLWGSWSGET</sequence>
</entry>
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    <accession>R0IUC8</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="R0IUC8"/>
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    <dbReference type="eggNOG" id="ENOG502S6CD">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_417453_0_0_1"/>
    <dbReference type="OrthoDB" id="5245206at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="623" mass="68745" checksum="13C9C0E37B873AD1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVK2</accession>
    <name>R0IVK2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_168059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023558.1">
        <property type="nucleotide sequence ID" value="XM_008025367.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IWC7"/>
    <dbReference type="GeneID" id="19401458"/>
    <dbReference type="eggNOG" id="KOG0162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001352_1_0_1"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000762">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 21" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 21" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14 21" id="KW-0518">Myosin</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 20" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="26">
        <location>
            <begin position="897"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="27">
        <location>
            <begin position="1634"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="24">
        <location>
            <begin position="1924"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="393"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="21">
        <location>
            <begin position="1449"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1791"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1978"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1799"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1858"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1870"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1890"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1907"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1986"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="2012"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="2033"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="990"/>
            <end position="997"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EOA88921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="2068" mass="230045" checksum="5F9159C1500BB7AC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXB4</accession>
    <name>R0IXB4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin interaction motif protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_167907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Han J."/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="558"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="969"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1112"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="301"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="621"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="974"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1294"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="846"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA89416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1543" mass="171582" checksum="AB6B17385C2D5A12" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IY59</accession>
    <name>R0IY59_EXST2</name>
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        <recommendedName>
            <fullName evidence="13">Dopey N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_159264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA89675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008024446.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3613">
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    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
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        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="394"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1358"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA89675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1855" mass="204552" checksum="5E564416B5A25C70" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0J033</accession>
    <name>R0J033_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_102675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="DUF7702"/>
    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
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    </dbReference>
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            <end position="37"/>
        </location>
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        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA90370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="328" mass="36820" checksum="76123A98DE7188D5" modified="2013-06-26" version="1">MGTSSSDTGLITYPAIVNIATLIIFFVYLVVSIWLIFRQGLGRSSPWIWLTLLSVCRLTQVSLDLAATTMYPIGQSSNTSLESGVAILTTMGLTPLFMSTSSLLNTTTRPKGRRMQWILLVLHIPLIISFILIVAGGIDPDSRDGPTFAATESTKAGVLLYVVCFVVLVWSTIVISARLYLADRDEVRILTTVVLSLPFFVVDVVYMMCFAFERWESNDFDGWQHMRFNVISGSVTIQLCMQVIMEWIIVALYLALGLELPSKAARLRRQIEDQMDQARNLDVDALQETVLWRLHDFVSRMVAAMIMPALQFAHWMLGKILRSGQNNN</sequence>
</entry>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="GO" id="GO:0005777">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Epox_hydrolase-like"/>
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    </dbReference>
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        <property type="entry name" value="HYDROLASE"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA90126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="487" mass="53526" checksum="1580EC2C470E42B8" modified="2013-06-26" version="1">MSGKLGNLAWSGFKLGFGLFSLAGVWTSAVVHNGALWARDSEEEKRELAAAQDRFWSLDREPLPGFRHAFFETSAGCRIHYVVREGAAAEAGKEKNVAVFIHGFPDSYMIWKHLLQSPSLQQDTILVAVDLPGYGGSDSLPSYGANEMLEALSEFMIAIRQQYLHDGKKTVAVTHDWGAIIGARLASEAHVLADHWIITGGVIPSLQRSNAEHRIQLAKQMLHTWVSSPMNTRLLKNGLNALKPIRDQFRRSFYIFVFHLPWPLNNTLATFGNYWFLRLLHSLGKGASTPSSPSSQSKQANTSLDAVEAAEAMAITTGPALEQLSSKTTLDAVSYGASLRARLTDRGMHEKTRIYRENFIFGKWDKSLETTAALYNIASSASSMRSSSSAGTLASSALQGALKAPATLMMGQYEPAFDQRLSLDNAREYLVRGSQVVVVKGAGHWLQLEHTGRRILEKTLQWALRSDAASAATPFDTMSDVRVVEAV</sequence>
</entry>
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            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACMSD"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="169"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA90525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="608" mass="67525" checksum="E8137CD2982BA318" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2C2</accession>
    <name>R0J2C2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_182526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021742.1">
        <property type="nucleotide sequence ID" value="XM_008023551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2C2"/>
    <dbReference type="GeneID" id="19401922"/>
    <dbReference type="HOGENOM" id="CLU_1703907_0_0_1"/>
    <dbReference type="OrthoDB" id="3682427at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="156" mass="16068" checksum="208CD0C5038F2059" modified="2013-06-26" version="1">MFCQPVTSIPQPPTTHPSCAVPIGGSNSSILDACCNGHINTIATYSAPETASSPGSATSKPVIVNSEDNDDCFQYCITDSPDIVQSCLAEKMAAFEKESASGKGMFGCFNVQKARSARRATGGNEGSYASAGLRISGSGSWALSILMALSVVGAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4G2</accession>
    <name>R0J4G2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-arabinitol 2-dehydrogenase [ribulose-forming]</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_18490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; D-arabinitol metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.250" evidence="5"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020090.1">
        <property type="nucleotide sequence ID" value="XM_008021899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J4G2"/>
    <dbReference type="STRING" id="671987.R0J4G2"/>
    <dbReference type="GeneID" id="19402065"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047038">
        <property type="term" value="F:D-arabinitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000240">
        <property type="entry name" value="SDR family oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="300" mass="32123" checksum="7AAD8730D2668FED" modified="2013-06-26" version="1">MPEKGDDRAALVNRQLPEMTLSTADNPLTAPRPPPEDLAPAQRAHYRFQVKGNAIITGGAGTLALEAAQALLEHGATGLALWDMNPDQAFESVKKLHAKFPTARIMTEAVDVRDESAIASALESSVKVLGSIDMLCCFAGVVGCTHAIEMAADEWRRTHDVNLTGSFLCAQAVAKQLRAQGTGGSITFTASISAHHTNYPQPQCAYNSSKTALLSLAKSLAAEWSSYGIRVNCLSPGYMDTILNEGDGLIRARKSWNDRNPMGRMGHPWEITGPLVLLCSNAGRYINGTDIIVDGGAMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0J584</accession>
    <name>R0J584_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_18715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    </reference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">28A</strain>
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    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA81033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008033007.1"/>
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    <dbReference type="STRING" id="671987.R0JI38"/>
    <dbReference type="GeneID" id="19402796"/>
    <dbReference type="eggNOG" id="KOG0242">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Kinesin_motor_dom"/>
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        <property type="entry name" value="Kinesin_motor_dom_sf"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 12 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="228"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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    <feature type="region of interest" description="Disordered" evidence="14">
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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            <end position="908"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
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            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
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            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
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            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
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            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="858"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="307"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA81033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="938" mass="99927" checksum="169E07BDF35FFF7B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0JIC2</accession>
    <name>R0JIC2_EXST2</name>
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        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_100927</name>
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    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <sequence length="187" mass="21761" checksum="186DBF027C28A3E8" modified="2013-06-26" version="1">MSELGQPVRIKYIPSLAFSLARRRMTTTGKPIKLPGKNWARSFERRNPRLKGRKVKAIDWKRHEQNIYTKVTHWFEVIKGVLQDPRVRPENVYNMDETGVMLNMLGSVKVLVSKDDLRDYRRVLTAENGYNDSKISLEWFTRVFDAQTSDRANRKPPVLVCDGFGTHETLEILEFCFANSITMCRLP</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
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    <dbReference type="eggNOG" id="ENOG502T2BZ">
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        <property type="entry name" value="Apq12"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="71"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81888.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="161" mass="18862" checksum="132204923E6A994B" modified="2013-06-26" version="1">MEFVQDYAALLPRLLPPSFANPLLHVVTTFLGVSRTLSTHLSPLLNKLMTQPDVASIVALLFIFFISLKILDMMYRAVLFWINLAIRLVFWGGILVVGLWIWNRGPDGFVDDISGLIEYWMHEYERYSGEIREFQMQKESQIRFKAGQQQQQQQQQKRGWR</sequence>
</entry>
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    <accession>R0JLQ0</accession>
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        <recommendedName>
            <fullName evidence="5">Aminotransferase class I/classII large domain-containing protein</fullName>
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    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_156992</name>
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        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
        </source>
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    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
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        <property type="protein sequence ID" value="EOA82143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008032251.1"/>
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    <dbReference type="STRING" id="671987.R0JLQ0"/>
    <dbReference type="GeneID" id="19397686"/>
    <dbReference type="eggNOG" id="KOG1359">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_015846_3_0_1"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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        <property type="entry name" value="Aminotransferase_I/II_large"/>
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    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
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    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="59"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="486" mass="53666" checksum="E5C33CBE74EA8E03" modified="2013-06-26" version="1">MSEATQDLGAQWREEWAVAQKVKGPSMKNDSVFYRNIEEELDISRKSGLCFPIHLPSHVTDFSTCDVLGMGHTGALREEFLKELEANPGFYMGAGGSRLLDGTTKYQDSFEKELAQLMGVESALVVHSGWTANQAIFSTVPRSGDVLVYDELMHATALSGMKISLALDQRPFRHNDVEHFIEVMEAVKESTPLVKAGKRCVIVGVESWYSMDGDICPLRELIDAAKEIFPHGNAQFVVDEAHSFGVCGSEGTGFVREQGLNDEVAITMVTFTKALSGAREYLHDLTLFYLDTLTSHPVYKKAYKKGMVDMPVHEDGAWHETPITHIVPLWTRRPRHALYLAFHLTRDGFNGCYIVFPIVAKGEDRVRLFLHAHNTKEDVKNLIQSMVTWIQEMLDIEASGDKNKLPTAARLAFDIIEKDKQIANGAAPVTSAVATTAATTVTSTVAVKSTDEVSKESGSLSLLNSISSLKLGLNGLGRMEMPSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JN84</accession>
    <name>R0JN84_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_121074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029712.1">
        <property type="nucleotide sequence ID" value="XM_008031521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JN84"/>
    <dbReference type="GeneID" id="19395838"/>
    <dbReference type="eggNOG" id="ENOG502SHQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_1_0_1"/>
    <dbReference type="OrthoDB" id="4357141at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="496" mass="55617" checksum="BE247CDFD9505F32" modified="2013-06-26" version="1" fragment="single">MKSKLGHPVRIKFLPSIAFSIARQRPSGKKPNKPPGQKWARCFAKRHPEIKARTVKPIDWNLHEKYTYEKMEHWFKVIQEVLQDPAVVPENVYNMDETGVMLSMQNCVKVLVGKDDPRDYRGAGVKRTMVTAIECISADGRVLLPLIIWPALTHRSNWTTYPTPGWHYAHSENGYDNSKISLEWLMRVFDTQTRETANGKPRVLICDGFGSHETVEVLEFCLANNIILCRLPSHTSHKLQPCDVAVFAALKAAYRDQVDRLGRGGVDTIGKEHFTSLYSPARARAFTKRNITSAWAATGLFPFNPERVLRGIPKPAAHPAVQTTATPTTPVTPVNVEDVRSLFDRIKPRAETLDESSKHELLRDTHMMAKATRIAIAERSFLQDHNRFLSKINGEVKARRSTKLLVLGTAQVMKYEQLVEAQARRAATAAAAANRAKRGRKRKSATLESKAPDATAETAQASRVSGPWRAPVARMVAGDCQVILVEKSYRCLIDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNW3</accession>
    <name>R0JNW3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_156561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029886.1">
        <property type="nucleotide sequence ID" value="XM_008031695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNW3"/>
    <dbReference type="STRING" id="671987.R0JNW3"/>
    <dbReference type="GeneID" id="19397638"/>
    <dbReference type="eggNOG" id="ENOG502SEH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093925_0_0_1"/>
    <dbReference type="OrthoDB" id="5326237at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="279" mass="30987" checksum="743D9BA3DF7C1C84" modified="2013-06-26" version="1">MEASDASVQPGQSWDEAQCTEALAQLERLQTQIDDLRLAIPRIIEPFHRPPNATTYKLYAQGVLGSQNGLNALKDQWKLPEVQSTFEHVKQSYGANADLSESVSVPSHGWVERARKAKKITNKSGSDVVEESGTIITDDDISRVVVEFRKTHPGLKLETHDDDHSIHIQFVSGSALLKFHVVIEREANGRHKLSAECLGMAEPCLATTRCLASRPHANDLRHLLDMIVAYKTIKGPCDKCAKLLDSAVLMPTARRSKQVATTEENFETVWVALHESCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JP93</accession>
    <name>R0JP93_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_43791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA83013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029513.1">
        <property type="nucleotide sequence ID" value="XM_008031322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JP93"/>
    <dbReference type="STRING" id="671987.R0JP93"/>
    <dbReference type="GeneID" id="19404872"/>
    <dbReference type="eggNOG" id="ENOG502SREK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021599_5_2_1"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="505" mass="57343" checksum="E80E188EDC547984" modified="2013-06-26" version="1">MVNVAGRSKGCSTCRKRRVKCDESRPVCQRCQRLRLDCDGPRSIVFVEGKIVKSRRTQKQSTPGSDDADTSLALWKRQDVEESISLSPVLQSSVQDLGLRFSEYQVYVCYLRQNLYPNGPVDRGLQKLDVSDLEVSRDPARREGTPLFNQAALTFAILLFGARHKQTQIIAEGYDMHGVTLRRLNKALSIPGCHTSDEIINVIVIMAMLEMYMPSGPQNWLKHMLGLERMLELRDPGSLIYASSQTLELYKGVRHMILLAALRNRTPSIFARPRWKAVLRTELSLETPQEQDLHDVLADCSVLTAASDEIARIWDPYDANCMQRLEQITTTAMNLLASLSMWKEQWDSDALNTRTIETDFEAFRAGAPPLLQTIYRFYDDTVTRMFMLYNTALIHVLHIMAATEGFQSNAHMSSSMGPDMHAHVPRTGTKAAIYAAGIETARSILEYMRHRSLRGDKYFPSPIVQWAVLTAWEALGRNESPEGRWMMRFLSSNDKYAIAKVAWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0JPW0</accession>
    <name>R0JPW0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_164656</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028986.1">
        <property type="nucleotide sequence ID" value="XM_008030795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JPW0"/>
    <dbReference type="STRING" id="671987.R0JPW0"/>
    <dbReference type="GeneID" id="19399201"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_2_0_1"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF13">
        <property type="entry name" value="PHOSPHATE TRANSPORTER PIC2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="114"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="215"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA83203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="308" mass="33790" checksum="3C8B33F62955755E" modified="2013-06-26" version="1">MASKLDAMKPQRKIELFSGSYFAACTMGGIIACGPTHTMVTPLDLVKCRRQVDSSLYKSNSQAWKMIYSKEGLRGVFFGWTPTFIGYSMQGAGKYGFYEVFKYLYGDKLAPGAPKQVVYLAASASAEFLADIALCPMEAIKVRMQTTLPPFAHTLREGWAKVIKEEGVGGLYKGLYPLWARQIPYTMVKFATFEETVTQIYKFLGKPKESFNGLQQTGVSFLGGYIAGIGCAVVSHPADVMVSKLNSDRKAGEGAGQAIGRIYGKIGFTGLWNGLPVRIFMIGTLTAFQWLIYDSFKVYLGLPTTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0JR21</accession>
    <name>R0JR21_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_156082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
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    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA83573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="328" mass="37151" checksum="317E91C5832229FA" modified="2013-06-26" version="1">MCGRPTGPWFAVPADALGYYVVAFDQRGYGRTTGWDTSSFINTNLAQFALTNLVRDVVTLVYALGYRKVKCIVGHDFGAVTASMCALMRPDLFNSLVMMSHPFNAPDLLPFDIAHADTEAHAPTPPLHVHAELAKLDTPRKHYKWYNSTSAAARDWANPAQGLHVFLRGYLHLKLADWNWTAQELAKLPYYYIMPLHKSMPETIADMMSDQNIAATEAWMSDQDLAFYVQEWSRTGFQGGLNYYRIMTDPVRMTDLQLFAGKKIECPSIFVSDAKDWGNYQQPGAMEAHPESCSDFRRARFIQDAGHWPQQEQPRKVVDELVAFLSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUU1</accession>
    <name>R0JUU1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_157224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EOA81274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JUU1"/>
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    <dbReference type="OrthoDB" id="18453at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="182"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA81274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="454" mass="50842" checksum="68BACE6E31D3D44A" modified="2013-06-26" version="1">MSDPLSPDKEFALMVATRTASVFSVIGSSIIVSTFIYFPFFRKPINRLVFYATLGNILTNVATLMSVSVIPKDGESPSGLCELQGLLIQWFMVADSFWVLCMAVNVLLVFFYGYDARQLRGLEKWYFVFSYGVPAVPVVIYVSLDHVGRPIIGSATLWCWVAVEHDWMRIAFFYAPAWVMIFGTCTIYTITGYRIWQRTVELHSLSQDSYHFGTIESTIGAKGGDMVNGSAANKIVVTTQIQCDIQSIDSFSSVQMFSMGTQPDDQITEQPLDDLEAQNSLHSSKSECHGGEVTMITSTLPADDSEVPNLSTPRFVGKKRGRTHAAAMAYFQVAFLMFIALTIVWVPSSINRMYQFVNARHPSFALNIISAIVLPLQGAWNAAIYIFTTRAECRRAWRETLSKTRGKPLQPQLQQDLFHKTISSSQATRESTIDIALDEILERGTWVHHTGIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWU3</accession>
    <name>R0JWU3_EXST2</name>
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        <recommendedName>
            <fullName evidence="7">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_164057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027814.1">
        <property type="nucleotide sequence ID" value="XM_008029623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWU3"/>
    <dbReference type="STRING" id="671987.R0JWU3"/>
    <dbReference type="GeneID" id="19398986"/>
    <dbReference type="eggNOG" id="KOG0076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_7_3_1"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Condon B.J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Dhillon B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
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    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
    </reference>
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</entry>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
    </reference>
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        <location>
            <position position="1"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="692" mass="76956" checksum="61455AEC2FB6EFC6" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZF9</accession>
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        <recommendedName>
            <fullName evidence="12">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">SETTUDRAFT_47616</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
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        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="AAA"/>
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        <property type="match status" value="1"/>
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        <location>
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            <end position="230"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="526"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="596"/>
        </location>
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        <location>
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        <location>
            <begin position="1116"/>
            <end position="1175"/>
        </location>
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        <location>
            <begin position="8"/>
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    </feature>
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        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
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        <location>
            <begin position="425"/>
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        <location>
            <begin position="502"/>
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        <location>
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            <end position="588"/>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1116"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA86268.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1175" mass="133165" checksum="4519728E242B5F1D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0K097</accession>
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        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="19 20">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA83099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353828" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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            <end position="156"/>
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            <end position="201"/>
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        <location>
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            <end position="234"/>
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            <end position="457"/>
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    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="PROSITE" id="PS52012"/>
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        <source>
            <dbReference type="EMBL" id="EOA83099.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    <sequence length="480" mass="52094" checksum="A03148D97D6DDF4C" modified="2013-06-26" version="1">MRLSNVLACFAALTTGVRAQGGLESLAENMPSCALMCFMQAIPTSTCATDLTSECLCSNTALNAAVGACAKKTCTVYELLQTKNVSAKGCGVPERYKGQRFLIGGIIGCALAVAAFILRMAASIGKQGRKVSWDDATMAVVLALAIPPTVFAHYLIENGLGRDIWTLNAQQITNVLFYYYVGEIFYVVALGISKISILFFYLRVFPDKKFKMLVYSVMGASALYTVAFFIVTTFQCRPLSFAWNQWDGLHQGSCNDIHLQGWIAAAINIVLDATVMALPMKHLAGLNMGLKKKLMVMAMFGVGIFVVVVSVVRLYSLIHFANTQNITWNYVDAGLWSLIEIDVSIICGCMPAHRFLIGKLWPKMRTTFQSSKATSTKRSDFSANTNLSATPSKLARVSIKGMTAKDDSFIPLSDIDSDSDRAHLTKEAQAHAGSEANTWPTPPTGAHTNQGSTSTTTVGGGHSGDRPQDWNWPTTGKEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
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    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
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    <dbReference type="EMBL" id="KB908855">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008032137.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0K0I9"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="IPK_sf"/>
    </dbReference>
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        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="882"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="923"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1105"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="1282"/>
        </location>
    </feature>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wang R."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58841" checksum="FA0BB91B8CA69FC5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0K163</accession>
    <name>R0K163_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caffeine-induced death protein Cid2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_142112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030434.1">
        <property type="nucleotide sequence ID" value="XM_008032243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K163"/>
    <dbReference type="STRING" id="671987.R0K163"/>
    <dbReference type="GeneID" id="19396655"/>
    <dbReference type="eggNOG" id="ENOG502S17Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081050_1_0_1"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21918" checksum="4B02E369C720F13F" modified="2013-06-26" version="1">MSKPSAQPTLTPQFCFNQTALRDFLRISRSSIDDSITQNLNALLTPAQRGFDPTSTSTRQLPVPGQTRALEPEQCEAFKEKVLFPSWAVRSDVLDYCAGVATSPDPDDPGSVLRQIEDAKARERTVDERLDPYSGRYFPMEARTESLAMLMRNERAVEKIIRMRTWSILGERCGIASEEADEAFDKWRATRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0K168</accession>
    <name>R0K168_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_139964</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029140.1">
        <property type="nucleotide sequence ID" value="XM_008030949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K168"/>
    <dbReference type="STRING" id="671987.R0K168"/>
    <dbReference type="GeneID" id="19396529"/>
    <dbReference type="eggNOG" id="KOG2534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008698_4_1_1"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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    </reference>
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    <accession>R0K4I0</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="248923at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
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        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
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    </dbReference>
    <dbReference type="Pfam" id="PF00180">
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    </dbReference>
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    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="85"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="170"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="385"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA87983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="486" mass="54122" checksum="BC608353338629F2" modified="2013-06-26" version="1">MRSPIPAPAVIRSAASVARLPRRQTCTFATRCLASQTAATSAQLLSPRRSTPRSSVATTSALYTQIGQFRMASSSGTQKIKVKNPVVELDGDEMTRIIWQVIKDKFIYPYLDIDLKYYDLGLPYRDETDDQVTLDAAEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPIVIPTIPRLVPGWKQPIIIGRHAFGDQYRAKDRVIPGEGTLEMVFTPKGGKPEVIKVFDFPAEGGVAQTQYNTTESISGFAHASFKMALDKKLPLYMSTKNTILKAYDGKFKDVFQEIYDTQYKKDFEAAKIWYEHRLIDDMVAQMIKSEGGYVIAMKNYDGDVQSDIVAQGFGSLGLMTSTLITPDGKTFEAEAAHGTVTRHFREHQKGKETSTNPIASIFAWTQGLAKRGELDGTPELVVFAEQLEKACIDTVDVDKIMTKDLALACGKKDRGSWVTTNEYLGAVERRLKSSLKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5R2</accession>
    <name>R0K5R2_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_173182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029298.1">
        <property type="nucleotide sequence ID" value="XM_008031107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K5R2"/>
    <dbReference type="STRING" id="671987.R0K5R2"/>
    <dbReference type="GeneID" id="19401233"/>
    <dbReference type="eggNOG" id="ENOG502S495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015886_0_0_1"/>
    <dbReference type="OrthoDB" id="5206661at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="591"/>
        </location>
    </feature>
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        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="591" mass="65214" checksum="B3504784B601B18F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>R0K643</accession>
    <name>R0K643_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">sterol 3beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_137253</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027481.1">
        <property type="nucleotide sequence ID" value="XM_008029290.1"/>
    </dbReference>
    <dbReference type="SMR" id="R0K643"/>
    <dbReference type="STRING" id="671987.R0K643"/>
    <dbReference type="GeneID" id="19396403"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_6_0_1"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
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        <source>
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    <sequence length="1448" mass="161965" checksum="A76D8BC920FFDA10" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>R0K697</accession>
    <name>R0K697_EXST2</name>
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        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
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        <name evidence="16" type="ORF">SETTUDRAFT_163780</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
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        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
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            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
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    </comment>
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        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
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    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
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        <location>
            <begin position="12"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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        <location>
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        <ligand>
            <name>NADP(+)</name>
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        <location>
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        <ligand>
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            <position position="106"/>
        </location>
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        </ligand>
    </feature>
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        <location>
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        <location>
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    <sequence length="491" mass="54129" checksum="8A53FCBC80074AD8" modified="2013-06-26" version="1">MSEAVGDFGLIGLAVMGQNLILNAADHGFTVVAFNRTVSKVDRFLNDEAKGKSIVGAHSIQEFVSKLKKPRRMMMLVMAGKPVDDFIELLLEGGAEEGDIIIDGGNSHYPDTNRRTNYLKAKGIRFVGTGVSGGEEGARYGPSIMPGGNEEAWPYIKDVLQSISAKSDGEACCQWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDIMKRGLGMKNKEIGDVFAEWNKGVLDSFLIEITRDIMYKNDDDGVAIVEKILDSAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSSLKQERGRAASLLDGPTPSFSGDRKAFIDNLEQALYASKIISYAQGFMLIQNAAKEYKWKLNKPEIALMWRGGCIIRSVFLKEITKAYRQNPELENLLFDDFFSKAIHKAQSGWRDVVSKGALWGIPTPAFSTALSFYDGYRTKDLPANLLQAQRDYFGAHTFRIKPEFANETYKEGQDIHVNWTGRGGNISASTYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">28A</strain>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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                <person name="Glaser F."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA85869.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="204" mass="23421" checksum="E6DB26A71FBA8607" modified="2013-06-26" version="1">MKNIYIIGAQSTGKSTLINALESCLEEIANEYSSQRPLVIREVARTVLRENHFRREDIATLPARALQLQRHILAAQYYAETTACPEGASTWYICDRSGLDPIVYAKCFVGDYAAAEMLASEFWQGLEDRMKESIVILCEAGCQWLEDDGVRLMPKDEKEWMRIDAAFRDLLRIRGISFYIISKDMTDLRERVQYVQRHAKSTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>R0K929</accession>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">SETTUDRAFT_179403</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="19401674"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="TF_fung"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="784" mass="87986" checksum="7FC2BC333B4F2B38" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAE8</accession>
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        <recommendedName>
            <fullName evidence="1">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_172122</name>
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    <organism evidence="2 3">
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA85752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="343" mass="38101" checksum="DE297342E7B089F2" modified="2013-06-26" version="1">MTVFCSIDFNQLSCENTDPGSPKRNYPPSSSGTTRVSQRTPYSSEYGSFPVAFQSLPGTNQMVEVIDLTQDSPPAQPAPKKSKRNTNGSVEEKRGTTFRRSATQSYLTVKERALTQRLTVLSRERCGSDDTPEEKVIIAGTTGNVYTVLVDREPSCDCPHAKKGNQCKHIVYVMLRVLRAREEIAYQLALLSSELREVFQNAPPIPGVGTNGKDGTQKQGEDGNRKPIEGECPICYDDLDNKENIDYCKASCGNNVHRSCMQNWKAASKGKTTCPYCRATWQEDTNLPGKLGDINTKGLARNEDGYVNIAPQLGLSGERDYSTYYSYWARSRSGYGGRRGDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCN2</accession>
    <name>R0KCN2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_144615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021432.1">
        <property type="nucleotide sequence ID" value="XM_008023241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCN2"/>
    <dbReference type="STRING" id="671987.R0KCN2"/>
    <dbReference type="GeneID" id="19396773"/>
    <dbReference type="eggNOG" id="ENOG502SNXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_0_0_1"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="77"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="179"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31519" checksum="120A5D8FA268A365" modified="2013-06-26" version="1">MADAPHAAALVEAFDRLVDEGVIVYGPHQTIRVDANGYPVEFRICPTLATKPHTVGATNHAFNHSRKWGPGSDMYCPDERLIITQLNQTHDLALNLFCVDRPQLLMLTLDSYKRQHEALDTDDLTVMLQVLRQFPGMYVIFNCGEKGGCSRVHKHLQALNGPPYAFEYLLSAVSDKHKTVPFRYFVHHFSEGFANTSASAVLSVYAHLLRQCPPALDAGPDEAPPHNVAMWHDRLVVIPRRSGSIEGASANTGGMLGSVWVTGQQQVDEWLRIGCAKVLGELGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCX6</accession>
    <name>R0KCX6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_47657</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026282.1">
        <property type="nucleotide sequence ID" value="XM_008028091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCX6"/>
    <dbReference type="STRING" id="671987.R0KCX6"/>
    <dbReference type="GeneID" id="19405148"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KD79</accession>
    <name>R0KD79_EXST2</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="R0KDG6"/>
    <dbReference type="STRING" id="671987.R0KDG6"/>
    <dbReference type="GeneID" id="19404140"/>
    <dbReference type="eggNOG" id="ENOG502QPIS">
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    <dbReference type="HOGENOM" id="CLU_070126_0_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354114" description="Inositol polyphosphate-related phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="296" mass="32212" checksum="E552DB8032B909D6" modified="2013-06-26" version="1">MHTFFTSALALASLVPLSIAQNSGTFNVLTFNVAGLPEILNGNDVPGDKTENTARIGQLFTKYDISLIHVQEDFNYHATLYANDKHPYRTPTSGGVPFGSGLNSLSNYPYTDFKRIKWNTCSTFDGADCLTPKGFTYMKVQFAPGVIIDAYNLHADAGTTAADNKARAANLRQVSDYIKANSAGNPVLVFGDSNSRYTRTDDIPAVFKDENGMTDVWVELIKKGVPPAKGADALLCQNPSTTNDCEIVDKVWYRGSSSVKLSATKFAYAGNMFLSDKGEILSDHNGVLVDFSWSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEB3</accession>
    <name>R0KEB3_EXST2</name>
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        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
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        <name evidence="19" type="ORF">SETTUDRAFT_89151</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA86502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026989.1"/>
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    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ING_fam"/>
    </dbReference>
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        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="351"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="207"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EOA86502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="409" mass="43695" checksum="2C3AD6D2A4161AAF" modified="2013-06-26" version="1">MAIAEDAATVLEQFVHDVANLPAEITHLYEEVQAKDNQIQELRAGIQQRDSSIQKFIKLNGSLVENPKEAGYAKTITASYEKAQILQEEKIGLVEKAAALLDRHVKRLDSKLRDLQNDGSMPMDAQMPSLLRESTANLVPPASMCNTGANTPLLPVSGNQGGGAPNLAQAAAIARLSSASSAGLGSRTNPSLQKMQTQALLNQQRLTNAQSAMQASARQEREMSVGSESKRRRPTGSLGPLPSASSSLGRQGSIGPGTPKPSTPGSRAGSVGPRPPKNALTVKKAKPQQPLRKAALTAKSGVSKKRRKGGSRASPSTTADDESVASEAGTEDEDMAGMGGGDGEEDESDDTKYCTCQRVSFGDMVACDNDNCRYQWFHWECVGIKEEPVGDWLCPECRNQAPTKIKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEK8</accession>
    <name>R0KEK8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_28059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026337.1"/>
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    <dbReference type="STRING" id="671987.R0KEK8"/>
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    <dbReference type="eggNOG" id="ENOG502SIAS">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
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            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA87759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="400" mass="44059" checksum="B25C96B959E3464E" modified="2013-06-26" version="1">MEDRSGQVLAIALTFLVLAWVTVSLRCYVRCFLVKGFGVDDYTMLVTLCFFTGYLIAQIGGAVHGTGVRREKLSDAQAQTALHFWFFCEIFYTLSTCMLKISVGFFLLRITIVPLHIWIIRLIMVVSGIVGIAYTSVVIFQCKPISYWWNLDPNAKGVCLSSALVMNFTFVVSGLNAFADWVFAILPVLIVQGLHMKKRMKVVVASVIALAAIGSTATIIRLPYTSSIKGYKGDFLYRTTDFAIWSTVEVGLGITAGSIATLRPLLKQAFEITRSGSAMPWSKPSLKSGQEHSGNQLSTLKPSIQKSVTITTSRARRESAGSDEETFLSSTMPSQAWQQQQGHPSYNTTRVIDERGARVSVDQDRRHKQGRGGSPAGASHSTVGSEESGKTPRIHVHERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEY6</accession>
    <name>R0KEY6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_47054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EOA87884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEY6"/>
    <dbReference type="GeneID" id="19405104"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA87884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="483" mass="53224" checksum="D62544E6193B9401" modified="2013-06-26" version="1">MSTDADGKIVVDNKEFISPQGSADLAFDEASEKKLIRKIDWRLLPILGALYSIALIDRTNISNARIAGMGKDLRLDIGDRYTIVLVLFFPTYFLLELPSNIVLRKVGSANWLSFIAVSWGAVMIGQGFCKSWISLAICRVLLGSFEAGFFPGCVYLITCWYKRYETQKRLGGFYLFSVGIGGLANILAYGLMQMEGVGGVRGWQWIFIIEGILTVVVAVSAWFIILDFPDKAEKKGFLTAAEAATVMQRIEDDRGDSVDDPLTWSKFCFHIRDIKLWGYATLFMSVTMPAYAFSYFLPVILLGMGYSAGQANALSAPPSFAAMIAAFAFAWLGDKYRVRAPVIAAQAILTIVGLMIVAYAQNHGARYFGTFLGVIGCQGNIPAILAYQSNNIRGQSKRSVGSALQIGFGAIGGIIASTTFKQKEAPRYFTGLWVTAGLQFYILAVLCCFTVYFVRKNRRVDQQRANGEPMDEIEGMAGFKFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFW7</accession>
    <name>R0KFW7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_184142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="428" mass="48005" checksum="EE6F66765DC8C30F" modified="2013-06-26" version="1">MPKLNHVVIAGAGPSGLLLGILLAKNLGIKVTILDADTKVNDNPRAAHYAPSAVYDFHRAGIINDVREKGFSPKGVCWRLKDTTFLGGMGREPEDSEHSMVVLPLDQLNPLLVKHFESYSGNKILWTHRLVGVEQDENGATALVETAQGEKKRISGDYLVGADGASSGVRTALFGKEYPGETLPQQIIATNVYLPFDERFGFWDSNFIVHPTDWYMAAKITKDGLWRVTYGDWDNLSKEELIKRQPLRFEQILPGNPKPNEYKLISMSPYKLQQRCAPSFRVGKIVLVADAAHLCNPFGGMGLTGGFADVGSLYDCFMGIHLDELDESILDLYSEIRTKIWREMIDPLSRENFHRLWDPAHEEKRKEFFKICDKVNNDPVWGKSVTDGLYQVRHDFTQYFKSKQKQEGKGMDNLRTGNGVLAQNSAAA</sequence>
</entry>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="158" mass="16692" checksum="9ACF61BE06553823" modified="2013-06-26" version="1">MKLIAALSTSLAALAAANPLPVDSEAKKALSTRATIVAVTCPAVSNAGEVNYSVRNIEEAFNIGSGLLVPPPEWVTGANGVDYPHYFGNYDNLPLPSDCTAPDVIDQQEYPILRTKVAFGDQSQPGPDRVIFARQTGGGFVYCITVYHKDGGGFGQCT</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19400512"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA88464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="58" mass="6128" checksum="99AFF06FA01F3592" modified="2013-06-26" version="1">MLPTGVAEEKQLGLGDITPPKAMECDGGPKGAVCRARLWLCDNGPDAASRRRGSMQSK</sequence>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0KHX5</accession>
    <name>R0KHX5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_38151</name>
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    <organism evidence="2 3">
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        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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                <person name="Barry K.W."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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</entry>
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="2">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="100" mass="10687" checksum="555EB81D5F576836" modified="2013-06-26" version="1">MTSAFRKDNHTKLGEAMQPQSTKSTSTKIKESITDTADKIAREVQPDSSKNHSQATMDKAGRSYDRNVHGSTGGSILDKTKSALGMGGHYKGAHTHGNGL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">28A</strain>
        </source>
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        </location>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020074.1">
        <property type="nucleotide sequence ID" value="XM_008021883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KRS6"/>
    <dbReference type="STRING" id="671987.R0KRS6"/>
    <dbReference type="GeneID" id="19401987"/>
    <dbReference type="HOGENOM" id="CLU_3070167_0_0_1"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="53" mass="5752" checksum="524FF299762C07BB" modified="2013-06-26" version="1">MTDSFKNAMINRSLGDIKNNLQFLVESNVITSAQHDIIAAQLPVSAENPLSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSJ1</accession>
    <name>R0KSJ1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_158287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021509.1">
        <property type="nucleotide sequence ID" value="XM_008023318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSJ1"/>
    <dbReference type="STRING" id="671987.R0KSJ1"/>
    <dbReference type="GeneID" id="19397806"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000907">
        <property type="term" value="F:sulfonate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044273">
        <property type="term" value="P:sulfur compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="92"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA90757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="382" mass="42884" checksum="761DB422BE34EC08" modified="2013-06-26" version="1">MAPALVEEAEATDYKSGVGPYKEFGIGGPKAFSKELELKGTEKHAPTKYPNYLPVWDNEKDQKLPPLEPFTHVEHGKDADPTFSSLLKDATVSDLTANIGAEVRGIQLSTLTSTQKDELAFFVAQKKVVAFRDQDFADLPIKDALEFGSYFGRHHVHPTSGAPEGYPEVHLVHRGTDDTSIREFFEERTNSIAWHSDVTYEKQPPGTTFLYILDGPDAGGDTLFANQAAAYARLSPEFRKRLHGLRVVHSGIEQADNSRNRGGIVRRDPVTSIHPLVRTHPATGEKALFVNPQFSRRIVGFKKEESDYLLNFLYDHIAKGQDFQVRVKWAPRTVVVWDNRVTAHSALLDWDDGARRHVARITPQAEAPYETEFEQAPANFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSN6</accession>
    <name>R0KSN6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_101140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021547.1">
        <property type="nucleotide sequence ID" value="XM_008023356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSN6"/>
    <dbReference type="STRING" id="671987.R0KSN6"/>
    <dbReference type="GeneID" id="19394830"/>
    <dbReference type="eggNOG" id="ENOG502S6FA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033740_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="379" mass="42377" checksum="06FC65E2C1C6AD99" modified="2013-06-26" version="1">MTLRGADPFECFCGRTYTYAIDLEEHRRARGHFPSHVCRGSCRHPPVAQYDFTIRKCGYCGKLCERLDIFEDHYIATGHCFCSECDLPFESQSAWENHCEVELHASEYRCCNCDITFKDIHALNAHMASRAHRKPLQQKHKVNARKAGKATTVSAGDHMCKICRRTVPSLQSFQQHCESLKHKPISALSCPTGEGCKRKFSAPSALLHHLESGKCCSGMDRDDIYDIVQLYDKDHTIHILPKLTPSSSTYLSAHGLSPDSGAPTASLDSSDGWLLVTPTHSQGTFRTVQALQQHIVSPTHCDKVYHCPRNLLPINSSKAETKQRKAKQFTTLSGLAQHLESGACRGGRQTFLRCIEFIQQHLGQWGLGGMRLLLPGSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSU0</accession>
    <name>R0KSU0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_30515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020234.1">
        <property type="nucleotide sequence ID" value="XM_008022043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSU0"/>
    <dbReference type="STRING" id="671987.R0KSU0"/>
    <dbReference type="GeneID" id="19403442"/>
    <dbReference type="eggNOG" id="ENOG502SJHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031811_5_2_1"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="64"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Tandem CCCH zinc finger" evidence="4">
        <location>
            <begin position="377"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA92029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55454" checksum="61ED66DF5F2238DF" modified="2013-06-26" version="1">MADTDDNCNPAQPDTAELLRDLEAVTARFREAFKVSNTKQEQPLAKDESSKISDIGESREAVIDPYILVLIDAHSHNFKKNHVQGAESGGAKAAAVLKEETTQYLSSRLSAKKYRTDIYVYANLKMISFPTAERHTAKKLLFTKADSTAALAKFAAGFSCNDVTVNYVNVADEQVVERKICALFKMHITEPHCQHILFGASGSARYTSTLGEHLMFADKITLIQRGNHDTSLMKWGLRTTIFERAFEPLPGINATSKSMGKPSNSYSSQSGKSTSSMYSTASSPRKENFKSQVKPFPKPPAPVISLPMPGASGKLPVNAAGHRIDMHMKAPTKSEWNEYHACIRTRKLCTMFHLGQGCNKAFCTHDHNPITDNQRYCLQYAMRALPCRNNGACREVHCIRGHACHRKACDTNPEPCKMPPGLHGIDFRVADWVVPNGSSERPDEVPDEVPDEVSDEVPEEDDASQENPIEVEESWGTRVGVLIDIDPYENEDGGEMSMWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0KT39</accession>
    <name>R0KT39_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_125372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021662.1">
        <property type="nucleotide sequence ID" value="XM_008023471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KT39"/>
    <dbReference type="STRING" id="671987.R0KT39"/>
    <dbReference type="GeneID" id="19395966"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_3_1_1"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA90977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="193" mass="21072" checksum="241EED03906EC403" modified="2013-06-26" version="1">MSMVSQTLQGAVLSLTSNVLAQAITAYQNKTPFSLNYTSVFKFVLFSVLSNPPNIVWQGFLEDQFPTNVPSAPAPTSTEKPGSKPDPTKTTLSKTNVLIKFVLDQTVGALVNTLMFLSYIGYVNALDKPGVNAMDVVVSDCMNNTWPMMKDGYKFWPAISLISFLWVPVDKRVVFGCSVGVLWGIYLSLAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTM4</accession>
    <name>R0KTM4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_18920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020144.1">
        <property type="nucleotide sequence ID" value="XM_008021953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTM4"/>
    <dbReference type="GeneID" id="19402146"/>
    <dbReference type="HOGENOM" id="CLU_1897503_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA92274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="134" mass="14797" checksum="2ADE39B082384A7A" modified="2013-06-26" version="1">MEDGVTLDLKYLNTVSYNAESASVGFRARRNIKRSLHCPRDPGAMFPGECSSSVGVGGPRTGRRDILLFTQPQLLLNFSIVTSVTFSTVEYNSIYGSLVAYPAIYNRRTNSKHSLALQLISPEYRGSQTTSSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTM8</accession>
    <name>R0KTM8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_84775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020358.1">
        <property type="nucleotide sequence ID" value="XM_008022167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTM8"/>
    <dbReference type="STRING" id="671987.R0KTM8"/>
    <dbReference type="GeneID" id="19405480"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_3_0_1"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000090">
        <property type="entry name" value="Lipoyltransferase and lipoate-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="85"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA92279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="434" mass="48602" checksum="57EF7ED814148790" modified="2013-06-26" version="1">MPCRGFFSIATAKVSATSASHTLLHLQPHRTLHGFQQCSITRRAFSSTFTETLADPANKLQSYVSTSNDPYLNLSIEDHILRRSPADSTILFLYVNRPCVVIGRNQNPWSEVNLGILNAARGAHDLKDSEPPGIGTVQLVRRRSGGGTVFHDEGNLNWSITCPRADFTRDKHAEMVVRALRKLGVERARVNERHDIVLDQGNERRASDPNDTHRTPYTIQDGILPRPLKVSGSAYKLTRQRALHHATTLLSSPNLHIIPHYLRSPAKNFIRAQGVESVSSPVSNIGLDVKAFQSRLQEEFALMYAELGTPSIVQTVGDDFLEIPDIRKGYDELQTEEWMWAQTPAFSLTFGLVDNVGIEIKVHHGAIKSLNFEHSELSDETQSALRSALVGLQLQEIRNWTAFLQNRIHAWDEQMAAIGNRLDDLLPVPEAYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KUE4</accession>
    <name>R0KUE4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_29962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020173.1">
        <property type="nucleotide sequence ID" value="XM_008021982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KUE4"/>
    <dbReference type="GeneID" id="19403381"/>
    <dbReference type="HOGENOM" id="CLU_2279231_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="102" mass="11042" checksum="4162C8D7FA2691EC" modified="2013-06-26" version="1">MPLMLGRRRLAAASLPLCLARHPRAPFVARQRQPAHRAAASSAHPPHSDNRLFFCSKRPPQGPARPASTILAWCHGTNASASPLHDDVGCGHARMPQTPRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5T6</accession>
    <name>R0I5T6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hxB</name>
        <name evidence="6" type="ORF">SETTUDRAFT_174644</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031557.1">
        <property type="nucleotide sequence ID" value="XM_008033366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I5T6"/>
    <dbReference type="STRING" id="671987.R0I5T6"/>
    <dbReference type="GeneID" id="19401338"/>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010913_0_0_1"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="5">
        <location>
            <begin position="649"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA80990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="825" mass="90844" checksum="71FDF6AF443587A6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6I4</accession>
    <name>R0I6I4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.131</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_24705</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14 19">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031226.1">
        <property type="nucleotide sequence ID" value="XM_008033035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I6I4"/>
    <dbReference type="STRING" id="671987.R0I6I4"/>
    <dbReference type="GeneID" id="19402824"/>
    <dbReference type="eggNOG" id="KOG1387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_1_0_1"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000168">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg11), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="16">
        <location>
            <begin position="66"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA81205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="275" mass="30598" checksum="A83B5FC6F42C6E40" modified="2013-06-26" version="1">MGGGECFGEAGQLFSGSLFVSGVQGHVKSLWGPYRTKRSKAFDIDVVFPPVAVEEVTEAVEVSESSEKNRGPDLVYIAQFRPEKNHRLILEAFASFLHSKVELPAYSNETPKLVLIGSVRNSHDDAKRVYQLRLLAHELNIKDNVEFICDAPWPLMLERMRTSSVGVNAMWNEHFGIGVVEYQAAGMIAVVNNSGGPKLDIVVDVDGKPTGFHASTAQEYAEGFRKALTLSPQETLDMRRRARRSAERFTDKTFADKWLGNAEKLVALQIKRTSK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <strain evidence="8">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="592" mass="66040" checksum="41C96D9BAF6E22FF" modified="2013-06-26" version="1"> </sequence>
</entry>
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    <accession>R0I8J9</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
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        <location>
            <begin position="141"/>
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    </evidence>
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    <sequence length="180" mass="16921" checksum="17D697BEEDFDDA56" modified="2013-06-26" version="1">MRSSIYVSAAAFALASAQGGSTSIDAFPQTAFATQTNSLGVVTGMPSVDTSIPPQPNVFTSIPPVVTAQPAPADIPAVGPGVHTLTLAGTGTGSLVNSTRTITVSANNSTTVALVASPTSSGAGATGSGASGASGSGASGSGASASRTGANRPDKTGAASNVKAAAGSLVGFGALMAALL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <begin position="20"/>
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            <position position="434"/>
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            <name>heme</name>
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        <ligandPart>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="492" mass="54892" checksum="1DAE35FF0E745A0B" modified="2013-06-26" version="1">MALPSMLLLLYVVVGLVAAKILYTGLTCPTKHLPGPWYTRFTHYRLKRAVITGQRIFYIDSLHKRYGPIVRLSPTEVGVADLDAFKEIHKIGTKYLKSEWYLRLANFPKAGVFTMLDPREHGPRRKLLSRSFSRSYLLQYWEPVVKEKARLAAQKIKADAMQGSADVYNWWMLLASDVSAHLAFGDSFGMLETGHTNQFMRVLKKLTMGAGIMVELPFLRILRFVPITAVQEMFNANDFILQGASKAVETARSRTGENNIFAKVIEDCEKEGDGHIDDMDVRIEAMNVIIAGTDTTGVTLTYLTWAVLQRPQLQAALEAEVAALNDHFTENDLIALPLLNAVIEETLRLYGAAPSSLPRVVPPGGASFAGHHIPQGVTVDTQAYTLHRDASIWSDPLTFNPNRWIASPNEGIAEAHSPAAKLAFHPFGAGARSCIGIHLARMELRYACAFMFRECAGVRLAQSTTPQSMEFENFFLIAPKAHRCEITLKQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0IDU6</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
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    <dbReference type="STRING" id="671987.R0IDU6"/>
    <dbReference type="GeneID" id="19403802"/>
    <dbReference type="eggNOG" id="ENOG502SGAD">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="315" mass="32095" checksum="1374781428112955" modified="2013-06-26" version="1">MCMCMCGWVRRWRNSQINWIIHPHIHILSLSLSISPSLSASVLAFLPSLLVYSQAGAYGAQATEAAVKQYAEVQALLSELVNGKEPAFTESVMSRLASAYATDLPAAVASAQSYASEGYGAVTDAASDVYASASSVVGAIFTPPPVIEDVLSQASASLDLAVESASIALYGTPKGAAEQASSSVASAYSSIQSQVSEKLYGTKAAQDSFESAARSAQAAISEAIFGTSTASDYLASVTSGAGDVYSSISSAASSAVYGPEQGAMESANRRIADAVAAANSRIAQMYAAVSGSAEDAASSISSAATQATKAVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IFW3</accession>
    <name>R0IFW3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_21470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028019.1">
        <property type="nucleotide sequence ID" value="XM_008029828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IFW3"/>
    <dbReference type="STRING" id="671987.R0IFW3"/>
    <dbReference type="GeneID" id="19402437"/>
    <dbReference type="eggNOG" id="KOG1698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959790_0_0_1"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000007">
        <property type="entry name" value="Mitochondrial ribosomal protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA84110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32435" checksum="C339D07944780EBA" modified="2013-06-26" version="1">MSAAIPCTRATAQRLAFRSIRCKRYASTETVAVDAAPATPLPPAKREPPPPPPREDLSQRLHRALYPEYYGEDGRPIDGASRVHTRRKQPSKPISAKWEAVMKQKTVNRELSHRFGVPVFKQPARNIKKTCPNPVATVTASQISQLDPTGARTRLFAKDNPECARVGDILLVRQRSGDPFAGVCINIRRRGADTAILLRGQLTRVGVEMWYKIYSPLVEGIEVVQRAAKRARRARLTYMRTVKHDRGSVENVVRMYLRQKAALGTAEGQKKKGAGAAAAAMGGKKKPGRGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHI5</accession>
    <name>R0IHI5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_111918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908737">
        <property type="protein sequence ID" value="EOA84446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027922.1">
        <property type="nucleotide sequence ID" value="XM_008029731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHI5"/>
    <dbReference type="GeneID" id="19395519"/>
    <dbReference type="HOGENOM" id="CLU_714031_0_0_1"/>
    <dbReference type="OrthoDB" id="3695114at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA84446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="387" mass="42724" checksum="9C488F6AD44C7B6E" modified="2013-06-26" version="1" fragment="single">LNVEELAAYATTKSQAGVPDEEILREITQMLREDGWKEAAIGPTIEAVVKRSSVVGGKGSPRQEGSPKANQNAVAQVMEQMMQLLSPMASRLEALERNQAKGRSESSPRVDTPPLPLTTVAKPAARKNKFPDLERFDGTRDNYLAAYATTKSQAGVPDEEILREITQMLREDGWKEAAIGPTIEAVVKRSSVVGGKGSPRQEGSPKANQNAVAQVMEQMMQLLSPMASRLEALERNQAKGRSESSPRVDTPPLPLTTVAKPAARKNKSLKEYMDKAIKLSNDLYRIQLHGRNQRNAAYSHVQGPLKVAQRDASLEAMDWEPSKANRARETKDRPRRSPLDCYSCGELGHIARNCPNTTRVKRAIPPSKGQRRQKQIKCPDDSDSEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHL8</accession>
    <name>R0IHL8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Biotin carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_136604</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027230.1">
        <property type="nucleotide sequence ID" value="XM_008029039.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IHL8"/>
    <dbReference type="GeneID" id="19396368"/>
    <dbReference type="eggNOG" id="KOG0368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_5_2_1"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="56"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="208"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="691"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1516"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="1862"/>
            <end position="2177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EOA84645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2280" mass="253941" checksum="AFBE2112B0AF846C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHZ6</accession>
    <name>R0IHZ6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_32049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHZ6"/>
    <dbReference type="GeneID" id="19403615"/>
    <dbReference type="HOGENOM" id="CLU_2016639_0_0_1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="123" mass="13134" checksum="E5AA8148566F5B7C" modified="2013-06-26" version="1">MEPWCCLTHHPVSLYSPLISYRHQTRHGPPSLVCLSPALPHNYFDSTPPPATPSIAARDIVAAYDIVAARGLVAAHDLVAAHDPIATHDPIAAHDLVAAHDPIAAHDLIAAHDPIAARSLLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIA4</accession>
    <name>R0IIA4_EXST2</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_163533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029043.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19398790"/>
    <dbReference type="eggNOG" id="ENOG502SSF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162157_0_0_1"/>
    <dbReference type="OrthoDB" id="4415650at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="118" mass="13209" checksum="3CEFBAC3574DEE00" modified="2013-06-26" version="1">MSSSTHIPLLFTLPPSNRHEFLLLDTSAKPSLKALNKQITATLAQSPNCAEFMAKHKAKDGPAEHIKEFRLHWDTKGRDAKIWPEYTIVTDDNFAALLEVLRANPTMGVLEIKVGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIP1</accession>
    <name>R0IIP1_EXST2</name>
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            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
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        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_89715</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA85025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="19405792"/>
    <dbReference type="eggNOG" id="KOG4655">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0034457">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
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    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA85025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="189" mass="21930" checksum="A3AD1FDDAD94BDDE" modified="2013-06-26" version="1">MVRKLKHHEQKLLKKVDFNTYKSDNDHREAAVMRRYAIQGRDDYRKYNQLAGSLRQLAHKIAALDPADPFRRKHEDLMLEKLWDMGILGTGGGGRGKLSDIEHKVTVSAFARRRLPVVMTRLRMADHIQAATTLIEQGHVRVGTDVITDPAYLVTRNMEDFVTWIDSSKIKRNIMKYRDKLDDFELEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJT5</accession>
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        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_137519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027593.1">
        <property type="nucleotide sequence ID" value="XM_008029402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJT5"/>
    <dbReference type="GeneID" id="19396417"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026278_0_0_1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343158" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA85121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="398" mass="43005" checksum="63BC5EF81EF57FBA" modified="2013-06-26" version="1">MVAFLVSIIAIVLSVLPSSSHAILIPGADNNHGYKVAVSHSPLTDTSRKDPYRPTENRSVMVSLFMPVPKDSCSKECQVAYMPLQTARIANEQFIVGGQRDIGVFEDIQYSVCCKSSARIDASKIPVVVLEAHVDTSRLLYSTMARFITANGAAVVLVDHPGDTSIVEFPSSTIYNSGTVALSNLSPLTAWNGTVSKALETRTLDIRFVLSQLASPSLLPTQFPSFTFSSALNTTSHGILGHGLGGTVATSFGTSANASSSSTLVSINLSGTPPLLTHRINNPPLFFFGRQDFRRENDIHWPRTWRQLTGQSTEFDLNDSAIFDVSDVPVIVELARNEGGKKNVVARGLSAYAPVQGTHAVTCFVENIVKMKMRLAAQNRDLGDCVRMFEGVVPYPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJW1</accession>
    <name>R0IJW1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_91397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027816.1">
        <property type="nucleotide sequence ID" value="XM_008029625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJW1"/>
    <dbReference type="STRING" id="671987.R0IJW1"/>
    <dbReference type="GeneID" id="19405900"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA85420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56102" checksum="310E562BC41B1E2B" modified="2013-06-26" version="1">MIPFQVPPLSQILATGAIFAVIYYITSAIYCIYFHPLSKFPGPKFAAFSRLPFAISAVRGQQYKWIDDLHDRYGKVVRVGPNELTTISSGAWRDLYLQRPQLPKDPHPQTPPLNGADSLFTADGSTHQRMRRTLLNAFNDRALRAQSPIIESHANLFIQRLRREAAKSVDSVVDLAKFYGYAALDVVSDLTYGESFHGLEGDNEHNWVMGFFLGAKFGAVRNHLSYFYPLDRIFGFLFLQLTAKIRKRNWQYTADLVTKRLDMGDLGSLRSDFVTPVIGNVKETKDKGITRNELNTHSLAITIAGSQLPTVALATATYLLLTHPLQLERLLGEIRSSFQQESDITIESTAGLPYLSAVIDETLRIHHPTPIHLPRLISSGGLRVDNEWIPGNTSSRNWAEPHKFNPERFLPPSHSWYDARFNSDDKEAFKPFSIGTRNCIGGKVFLAEARILLARTLWNFELALEPSTRVDDWLDQKAYLVFEPKPLCVKLLEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>R0IL72</accession>
    <name>R0IL72_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_169593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="KB908637">
        <property type="protein sequence ID" value="EOA85815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026601.1">
        <property type="nucleotide sequence ID" value="XM_008028410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IL72"/>
    <dbReference type="STRING" id="671987.R0IL72"/>
    <dbReference type="GeneID" id="19400959"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="131"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA85815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="447" mass="48696" checksum="72F1DDC6A30A06AA" modified="2013-06-26" version="1">MAAAVADDVANLKLDDSQSKPTNGDKPVGDADHEDSDDDNEAEDGAPEAGEGAAKKKKKRKPRKKKKPGAAGGGGGPKVQTSPPRVRIDELFPNDSYPEGEIQEYVNENTYRTTSEEKRHLDRMNNDFLAEYRKGAEIHRQVRQWAQGFIKPGMSLTEIAEGIEDSVRALTGHQGLEDGDGLIAGMGFPTGLSINHCAAHYTPNAGNKMVVNYEDVMKVDFGVHINGRIVDSAFTVTFDPVYDNLINACKAATNAGIKEAGIDVRMSDIGAAIQEVMESYEVEIKGQMLPVKCIRNLNGHSIGHFTIHGGKTVPIVKGGDQTKMEEGETFAIETFGSTGKGYVRDDMETSHYAKRADAPKVALRVSSAKTLLNSITKNFGTLPFCRRYLDRLGHDKYLLGLNNLVSAGIVEAYPPLCDIKGSYTAQSEHTFVLRPTCKEVLSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILE8</accession>
    <name>R0ILE8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_47728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026423.1">
        <property type="nucleotide sequence ID" value="XM_008028232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILE8"/>
    <dbReference type="STRING" id="671987.R0ILE8"/>
    <dbReference type="GeneID" id="19405150"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_0_0_1"/>
    <dbReference type="OrthoDB" id="3679662at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053212">
        <property type="entry name" value="DHP_3-monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="MONOOXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469:SF2">
        <property type="entry name" value="OS06G0597600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48338" checksum="E34921306C83EC40" modified="2013-06-26" version="1">MSGRQKLVIVGGSVAGLMIAQLCKAKYDVTVLEQSKDIYSKHCTGGLSLGEWAINIFKTHIPNGELIKNAIFHKEIAIVSAFEGETKQSTIPLENYPVCTTTWDAVYRTLLSDIQYNSRTSEPMLLTNTKVTHAKYEDNVWKVSYTTGATYHVEQADILIAADGAHSTIRKATVTNAQPHFTGRLAWRGRVPGSIVIPQELKGVQEGLLVFVRMGGHYIILRVIFLSALEPPFLTISSYAVPNIEIADTSGKASMEWCWYYPYTEGASLDVENIAVSFVELDELFKDDLRVQRINETWKKHLQMTKDEVPPSIWTVLSSCDTPWVTKVTSFQEGLVDPCDQGSIEGSENSGDCRSVSLLGEKLFLIGEACAQLPPHIGASVDATAEQALAITDRLEGNIDSKTYLGWVKEVTARRHEDSEDTGEMGMYDHIKYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILR4</accession>
    <name>R0ILR4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_151762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908637">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILR4"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF6594"/>
    </dbReference>
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        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="15"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="293" mass="33146" checksum="F18D34B54C4599E2" modified="2013-06-26" version="1">MLHPQDTLQQYVIGYPKLAAKMEILPEVAIFRRFGALNAQNLLYMQAELVYLKKELRRCQLEDHCNPSEKRSKYALDWRWLKVSEGTEAGEQQALILRIRDLLKDHNQKTKKIKFSCSYQLDDALIQQAEILKYPKPGTWDLHHMQDYLHSPEMGEDALNGDDASVWGSACYRKSQSPDLITLCPRAKKDAFSSWAAESTIGMLFRCGCTRLMKPSRVHGVVGYEDSTVYRVTYWITSILASLIPIASIAVLYRVHSMSARLGIIAGFNVLVSVCLMALANAKRAEVFAITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0INA4</accession>
    <name>R0INA4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_151082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026067.1">
        <property type="nucleotide sequence ID" value="XM_008027876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0INA4"/>
    <dbReference type="STRING" id="671987.R0INA4"/>
    <dbReference type="GeneID" id="19397100"/>
    <dbReference type="eggNOG" id="KOG4011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016434_1_1_1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="194"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA86475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="554" mass="60905" checksum="357B877B7A5DE89E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPF2</accession>
    <name>R0IPF2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_87353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025419.1">
        <property type="nucleotide sequence ID" value="XM_008027228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPF2"/>
    <dbReference type="GeneID" id="19405645"/>
    <dbReference type="eggNOG" id="ENOG502R1YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392304_0_0_1"/>
    <dbReference type="OrthoDB" id="3799259at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="715" mass="79432" checksum="78C599998E406334" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQ09</accession>
    <name>R0IQ09_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SETTUDRAFT_88617</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025397.1">
        <property type="nucleotide sequence ID" value="XM_008027206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQ09"/>
    <dbReference type="SMR" id="R0IQ09"/>
    <dbReference type="STRING" id="671987.R0IQ09"/>
    <dbReference type="GeneID" id="19405719"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_0_0_1"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="163"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EOA86806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="233" mass="25144" checksum="5854BC2F1E17F6C7" modified="2013-06-26" version="1">MPALANTARAVARSWTAHQLPVARAAGCTAMQTRNASASSFDSPFKGTPETTKIPSFAAYRNKGGETGPKVFQYFMVGTMGALSALGAKATVQDFLVNMSASADVLAQAKVEIDLAAIPEGKNVIIKWRGKPVFIRHRTEDEITEAENTKWESLRDPQPDSARVQKPEWLIMLGVCTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPAYDFPEEGKVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQK1</accession>
    <name>R0IQK1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1264-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_153896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025644.1">
        <property type="nucleotide sequence ID" value="XM_008027453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQK1"/>
    <dbReference type="STRING" id="671987.R0IQK1"/>
    <dbReference type="GeneID" id="19397349"/>
    <dbReference type="eggNOG" id="ENOG502QR3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071931_2_1_1"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27536" checksum="A0DDC5CD384DFEFC" modified="2013-06-26" version="1">MESLPVNNKAAGEPESTYNRALETGAAATQNFAPVNRVCAHLNAFHAYAHDAKRDAVEANHYCAHVNDEVRQCILYDSPEPGARIIGIGTSLVRLDSGARLSVVPEYMISPKLYETLSAEEQRLWHSHVFEVKSGMLIMPRPTGVPEAAWEVAENREMEEVVELYGKIYHLWQTDRGDKLPLGPPQLMTSYTAADQMPDFEKRMQDRDGRFASDYKRKKEVRKYIGVPKIHENADATWAKGGLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0IQX9</accession>
    <name>R0IQX9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_19606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024927.1">
        <property type="nucleotide sequence ID" value="XM_008026736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IQX9"/>
    <dbReference type="GeneID" id="19402214"/>
    <dbReference type="HOGENOM" id="CLU_750412_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="390" mass="43664" checksum="C047D7864D53297C" modified="2013-06-26" version="1">MYVTIEAASTLSTLSLFPKAKTALLSPKAYNAPFSAASENKWTYDHSTGGHGGFFSRNAVRSRPNQISSSAPLAQPAGNRTGTGLTLISFQELVKIAASSQASEYPNDTATDHPSDSGDTSEKLLKPSPPPQYAAKANLRSSSPGSSTTHLLPETRGSLSKNTFPQSGTREEPILIDDLMDKDDREPSQQVLDLVDDDGEDTELDEDFNLMQYPFCKNMRQTTPEEGTPTAGDQRPKDAHRRSLRGVRTSAQCAGFLDGKKPVDNMLEEISDIWNNVQAQWMELYSKPSMKIGNSMGRFNTKICKADEKFRLEGICPEHVRVLARDWDLVHQLVYSRIERRSERRLMNRFKREMRRLKRASKVLKNCDPTTRADVEDDNENDMDWTPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRR9</accession>
    <name>R0IRR9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_41741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025146.1">
        <property type="nucleotide sequence ID" value="XM_008026955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IRR9"/>
    <dbReference type="GeneID" id="19404723"/>
    <dbReference type="HOGENOM" id="CLU_102649_0_0_1"/>
    <dbReference type="OrthoDB" id="3757079at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343260" evidence="1">
        <location>
            <begin position="29"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="202" mass="21871" checksum="FDE486F2B25F954F" modified="2013-06-26" version="1">MMRRLLVPLVLTMLLYALTVAAVAPASALVIALESPDDYINNAAPLLFTAPTRNPPNEALIAIANTPTQTLTKTAQIRQTWLPSAPKNPILIFPFHLTLTRSCSDNDDENSISALVRNGDFTTSVVHLSADTSAMVEHRIPGYPSAFRVGPFDAEKGGVRFLWENAEGGWIKEMDCSFILGWKSQFRGKAVATAAADTGEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRV5</accession>
    <name>R0IRV5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_87699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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    <reference evidence="1 2" key="2">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8313" checksum="7D5EE265E00C98E4" modified="2013-06-26" version="1">MGTFDGHNTSVHLYVRQIQHRVRLYRYQRVLEVLPLCMKGDAVDWYSSLSDGQIHRMTTSINKWIIALRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZC3</accession>
    <name>R0IZC3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_127397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022794.1">
        <property type="nucleotide sequence ID" value="XM_008024603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IZC3"/>
    <dbReference type="STRING" id="671987.R0IZC3"/>
    <dbReference type="GeneID" id="19396012"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029658_0_1_1"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA89901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="240" mass="27189" checksum="308A311466FE9FA2" modified="2013-06-26" version="1">MSGTPDENGVDHWSCVDEFPEHLKKYWFQRFKIWEKYDQGVWMTEDAWFGVTPEPIANKIAAHIAESAPKEKTVIVDAFAGVGGNAIALARSGRWERVFAIEKDAQTLKCAKHNAEIYGVSNKIFWLNADCFDAVNRFAGQKNVVVFASPPWGGTEYGADNVFDLTKMEPYNLDKLYKSFTKISKEVVLYLPRTSDLNQIARYGHDGKKLEVAHYAMMGASKALCVYFGDFDFELEQEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZF0</accession>
    <name>R0IZF0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_67881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022518.1">
        <property type="nucleotide sequence ID" value="XM_008024327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IZF0"/>
    <dbReference type="STRING" id="671987.R0IZF0"/>
    <dbReference type="GeneID" id="19405340"/>
    <dbReference type="eggNOG" id="KOG4035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187488_0_0_1"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27064" checksum="87912329F5957848" modified="2013-06-26" version="1" fragment="single">MAFEVSYDLENEQQFWDELDDIVSTRCHQHEIIDNSLRSFLNVTTNYKSDYLQTDYSIAKCIFRMLEGELFASNKQYVRRQIIYCLLQEDDNPTLHIVAAFLMYDGRNSKDDVVFEMMHSEGTFARLVELVQKPSVQEEPSLHQLLLQLLYESSRIQRLTYEDFMAVNDAFILYLLGIIEGASDDADDPYHYPVIRVLLVLNEQYLVASTSRHGDGRGGITNRVIKAISTHGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZG0</accession>
    <name>R0IZG0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_45998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporineae</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <end position="34"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="400"/>
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            <begin position="16"/>
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            <begin position="133"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
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        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
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        <reaction evidence="1 12">
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        </reaction>
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            <name>Zn(2+)</name>
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        </cofactor>
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        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
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    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
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        <property type="entry name" value="PMI_I_2"/>
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        <location>
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        </location>
    </feature>
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            <begin position="166"/>
            <end position="267"/>
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            <end position="402"/>
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        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA90280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="455" mass="49917" checksum="B9E86975F227E412" modified="2013-06-26" version="1">MRNPLIRLECGVNSYDWGKVGNDSAAAKFHAATASDFSIEEEKPYAELWMGTHPSLPSKDLETKRSLLELVQENQALLSTDIAERYANKLPFLFKVLSINKALSIQAHPNKKLAEQLHASDPKNYPDDNHKPEMTIAVTPFDGLCGFRPLAEIAHFLKTVPSLRKLVSEEEATKFEETISGKETSDKEEDVQANKKALQSAFTKLMNTDKDALAAASKELTEAAKAEGDNFAGGGPPSNTGKELADLVIRLDSQFPGDIGLFVQFFLNYVKLNVGEAMFLKADDIHAYLSGDIIECMASSDNVVRAGFTPKFKDVENLTKMLTYSYAPISEQKMEPKDYSRVRLNAPAYSSNSSNMLYNPPIPEFAVVRTALNRTGAKATFDPIDGPSIILCTKGKGTISVGPKEEELSEGFVYFIGATAEVIIKSDVDAEDEEGAEGLVTFKAFCEIEDDKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0J038</accession>
    <name>R0J038_EXST2</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_103040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="protein sequence ID" value="EOA90375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="19394959"/>
    <dbReference type="eggNOG" id="KOG0254">
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    <dbReference type="OrthoDB" id="6133115at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS maltose transporter, putative"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="89"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EOA90375.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="520" mass="57049" checksum="F500573795662495" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0D5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">SETTUDRAFT_158831</name>
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0D5"/>
    <dbReference type="GeneID" id="19397873"/>
    <dbReference type="HOGENOM" id="CLU_2832803_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="66" mass="7731" checksum="A71478DC43CF1BE3" modified="2013-06-26" version="1">MQENIFRRYAQSASCTGSSAYASRLHLPSRFTLNALQYCAVPRHHHRWNTAKPALTQRPRLLFVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0S2</accession>
    <name>R0J0S2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_146496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022372.1">
        <property type="nucleotide sequence ID" value="XM_008024181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0S2"/>
    <dbReference type="STRING" id="671987.R0J0S2"/>
    <dbReference type="MEROPS" id="M67.A02"/>
    <dbReference type="GeneID" id="19396871"/>
    <dbReference type="eggNOG" id="KOG1554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053034_0_2_1"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA90560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="354" mass="39284" checksum="B2CA75C9AC86EE66" modified="2013-06-26" version="1">MGAALKTWELENSIKLVDPSKDALYNYNPSAQKAINEAHPWRIDPNYFTSVRISAIALLKMVMHARSGGSLEVMGLMLGKIEAHTFVVTDAFRLPVEGTETRVNAQDEANEYMVEFLQRAREQGQMENAVGWYHSHPGYGCWLSGIDVNTQKTQQQFQDPFCAIVIDPDRTISAGKVEIGAFRTYSTEYVENQQKSGGGSKMAAGTDSDGFETIPLGKIEDFGAHASHYYSLEVSHYKSSLDSKLLEALWNKYWVQTLSSSPLISNRDYGTKQISDLARKMQQENTNSKRFFKGGGQGYAAAHESKNQLAKLGAAGSKIAREEEMGLLAAKVKDKVFNLTSEAEAKSHEVEMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0X7</accession>
    <name>R0J0X7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_167285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022275.1">
        <property type="nucleotide sequence ID" value="XM_008024084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0X7"/>
    <dbReference type="GeneID" id="19400117"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027968_1_1_1"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA90426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="444" mass="49618" checksum="ACF735D00F9EA747" modified="2013-06-26" version="1">MSEKADHLCVLVHGLWGNPDHLKYISTTLGETFPQDKLHVLVAKRNAGSFTYDGVDTGGERVADEIEGKLEELAESGHNITKISVVGYSLGGLISRYAIGLLFRRGVFDKIQPINFTTFATPHLGVRTPLKGYHSHLWNVLGARTLSRSGRQLFGVDKFRDTDRPLLAVLADPESIFIQALAQFKNRSLYANVINDRTVTYYTAGISSTDPFVDIDNVKVNYIDGYANVIVDREHPVSPKEPEEVPAFAQRLTDGTRTMIGRASIVALLAIFVPIGVSAFLINSAVQSVRSHQRIQLHEQGRSGIDYARYRIPLMINAVRREAEDMYENANNAHEQEYLSSSDEAAMSSKQHSANGMVQKKYCDVEGDSIQEQKDGATLKFPTLALTPAQFKMIEALNNVGFKKHPVHIHNHRHSHAAIIVRMNKKTFNEGKIVTQHWLDNFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1B4</accession>
    <name>R0J1B4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_166666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Schackwitz W."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
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        <text evidence="4">Belongs to the cyclin family.</text>
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    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
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    <dbReference type="PANTHER" id="PTHR10177">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
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    </dbReference>
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        <property type="entry name" value="Cyclin_A_B_D_E"/>
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    </dbReference>
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    </dbReference>
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            <end position="137"/>
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            <end position="263"/>
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    </evidence>
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    </evidence>
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            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="439" mass="50383" checksum="96C3515544EDCC72" modified="2013-06-26" version="1">MLLLDLPTELLLSVLEYVNVWEWKQVRQTCRSLSKLATPLLFQEINFKLCEHGCESLYNISQNYMLNRFVKTIALRRIRGYRKFADFNAWVECIHQPGTPDHIPWKTCHTTYYENEELRSQLMPYEEWARLSKEEKSVLYEAYNADRELQNKDAWSIANAEAGNVSVTQFAKALQTLPNLSALEHEPRFLDTDAWALQWRDVYFHPDYIIGFTDNDEDEDIDALQLSVVLERLAYFRGKGQRLQKMSMYIGGPAFATPARLKLLRLSGSHKITRLCRSIHATSPEADADARTGLVESDEIKLLYRRLQAMACAFSDLTCLDFCVSDNDEMTGCMESAAKLVLYFLISATKLQQLSLAFGRLVDGYLRPTYGSQESEQARGSIMLLSHLSLHSRWNQICNVELEIATDRKTLMGFLLAHKDTLRCLTLVRTSLKLGNAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0JIF7</accession>
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        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_166460</name>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
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    </evidence>
    <sequence length="340" mass="37095" checksum="34F379150DA754E5" modified="2013-06-26" version="1">MNDEAESSRARRRHDDGAPAPTPDDDDDDVGALEEAMARLEAAAERGREKQRQQRRVDAKRKRIQMLGELLRELDMVVYLELITLYHLDCSFFWLAFKAFIHGTLLTPMPDTATAMRPPDEPKPFLPLLLFSFGVSLALHLSYPAPAAGEDTRGYLHGGLMIDFIGQQGPTSKWKLGALDVCILLLQLVMVSVHVKRRELKKKLARLAAAGGAAAATAAAAATATATATAGGEADGEQDADDEERGVLHRTDTLSDLGTEPADDEDTLLAPSEAGHADAMEVLSSGQCVIGDFTLIDTLLHENRNYSAYRLTRTEAGMNDMPETLRRLNTLRTRFGVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0JL94</accession>
    <name>R0JL94_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_165536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030372.1">
        <property type="nucleotide sequence ID" value="XM_008032181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JL94"/>
    <dbReference type="STRING" id="671987.R0JL94"/>
    <dbReference type="GeneID" id="19399505"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353570" description="agmatinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA82033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="400" mass="43931" checksum="BFF24C6BE65DCD67" modified="2013-06-26" version="1">MRLNWTTLFAYAAYVSAHGAHHAEGQDSFSQERLDELEKKWGTDWPFSGISTFAHLPYTRCLTQPETTYDIAILGAPFDTAVSYRPGARFGPRAIRAGSSRQTSFRGFNPRANLNPYTSWAKIVDCGDIPVTPFDNALALRQLSEAFMELGKRPATEKSTQSGVQYFKKPKLLTLGGDHSIALPALRALKEVYGEPITVVHFDAHLDTWHPARYPSTWINSEDPTTQSFFNHGSMFWFASTEGLIANGSSVHAGLRTRLSGDDATDYDDDTQQGWHRIVTDDIDDIGVKGVIASIMDRVGTERPVYLSIDIDVVDPGMAPGTGTPEPGGWSTRELLRILRGIEGLNLVGADIVEVSPAYDAAETTGLAAAQIEYEVLTNMVHKGLVEQARTGKPQAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLW9</accession>
    <name>R0JLW9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_122534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030502.1">
        <property type="nucleotide sequence ID" value="XM_008032311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JLW9"/>
    <dbReference type="STRING" id="671987.R0JLW9"/>
    <dbReference type="GeneID" id="19395885"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078327_0_0_1"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24240" checksum="00FCA88830AC8AAF" modified="2013-06-26" version="1">MALPAPTIDLLLNLIDTRPQSILSSLAQHPQLASARDAHGYSLVHAAASYNQLPVLRHLVQKYNADVNILDEDGETPLFAAEKVEVAKCLVEELGADTTIQNGEGQTAEQKIGDEEGEAHEVYQYLRSRRTGQQPVPAGLVEAEGVHPPPPLPGGVHVNMGTMEEDAAEAPDPEIRKRIEELAAREDYNSDEVQSQLRELVQDVVSGMGAADDAARSVRRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JN72</accession>
    <name>R0JN72_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_48320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029515.1">
        <property type="nucleotide sequence ID" value="XM_008031324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JN72"/>
    <dbReference type="GeneID" id="19405168"/>
    <dbReference type="eggNOG" id="ENOG502SHQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_1_0_1"/>
    <dbReference type="OrthoDB" id="4357141at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="111"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="425" mass="47763" checksum="833751044A8506FC" modified="2013-06-26" version="1" fragment="single">SLAFSIAHQRSTKSESIKRPGKNWPRAFEKRHPELQARRVRSIDWKRHGNNIYEKIVEWFDVIGQVLQDPCVLPENVYNMDETGVMLSMLGSAKVLVGKDNRQGSRGAGVKRTMVTAIECISADGRALLPLIIWPASTHRSNWTTHSTPGWHYAHSENGYNDSKISLEWLKRFCFTNNIILCRLPSHTSHKLQPCDVGPFAPLKSAYREQVERLNQGGVDIVGKEHFTYLYNPARDRTLTKRNIRAGWSATGLFPFNPERVLRDVPKPPAEVSNISNPGTETASADVSDDMPRTPTTPVTPVTTEALTSLHNLITKDTHVLEKTSKDRLQRRIQKLASAAKVSFAEQALLKDRNHFLLQINREAKTRRSTKSVVLGKAKVMSFQDLEEARAKRAAKEQALAGKPKRGRKRKSDALEGSTVLPSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNI4</accession>
    <name>R0JNI4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_121229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029792.1">
        <property type="nucleotide sequence ID" value="XM_008031601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNI4"/>
    <dbReference type="STRING" id="671987.R0JNI4"/>
    <dbReference type="GeneID" id="19395841"/>
    <dbReference type="eggNOG" id="KOG0670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_5_1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="450"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA82773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="814" mass="90810" checksum="5FA39CB6B61955EE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0JVE4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_20485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026897.1">
        <property type="nucleotide sequence ID" value="XM_008028706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JVE4"/>
    <dbReference type="GeneID" id="19402324"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897550_0_0_1"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="304" mass="32502" checksum="08E5E4C984D5F597" modified="2013-06-26" version="1">MTTKITSLDSQSGAPSVPNPTPATEPIGSPFGSDPIDPPPEMDYAAVAKILGPIQESLNEAAMEAGYPSPPINTPVVGSPEPSVIFRQSMPRGRGFSVVGDRLAQLKLDNRKPRHREGDTASTSYSPEPSVAEDEEAEAASISEVLSDNGRDKQCCGHGRRSLAPISVTEGSVPIALGSPAVNPRIVEYLTFTSDDLPTNSVASCLPSTLMETGTTSLKTAIDGSSDRNSLKSDGVTEKSNWAEELEDAVDRACLRLEQLADDEVKMDASKTFEEYYIARLERLLGSDKRAVPVNVQKVKKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JVV1</accession>
    <name>R0JVV1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Opsin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_44481</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030729.1">
        <property type="nucleotide sequence ID" value="XM_008032538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JVV1"/>
    <dbReference type="GeneID" id="19404926"/>
    <dbReference type="eggNOG" id="ENOG502QQVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054785_0_0_1"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA81609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33180" checksum="6956B88893DFF2A6" modified="2013-06-26" version="1">MIVDQFEDVLGKVPSGSPPVAPIPSVVPGSEPIYQVAGDAGQKVLWVVFAIMLIASGAFTLMSWNVPLNKRLYHVITTIITLTAALSYFSMATGHGVALQKTVEREQHDHVPDTFTTVYREVYWARYVDWVVTTPFLLLDLGLLAGMAGGHLFMMVTADVIMVLTGLFAAFGSEETPQKWGWYTISCISFLFIFWHLGLNGGANARAKGEKLRSFFVSISVYTVILWTAYPIVWGIADGARKVSVDSEIIAYAILDVLAKAVFGAWLLIVHANMRESDAELNGFWANGLSREGAIRIGEDDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>R0JVV6</accession>
    <name>R0JVV6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_157515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Steffenson B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053112">
        <property type="entry name" value="Fungal_Dehydratase/Hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617:SF1">
        <property type="entry name" value="ATTH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617">
        <property type="entry name" value="TERPENE CYCLASE ASQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343677" description="AttH domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39687" checksum="7BB62C62FB963169" modified="2013-06-26" version="1">MKWLSKFSLLPVLLFTCTSLGFQRSAPDVGPLSTNYTLQAGIFNLTKTQEASRYRVNSFWTIFFLQGSNKHDYFLVAHFFTNGVASPPTSSLRVSLLDITDKYYFGATYSTPNATYNAEAFRFHDDKFESYSTSPDLFSTQVVKSNVKGAEFHLESAARGPNLYGSGNGLFFWGTDWTYELAYPEQWVTGNLTYKGEVIDIVSEKSMSWLDRQYGPGLGEAGWYLWILYLDNGAKMTIWHSESVKGGPVQYFTTVLFPDGHHEVYPIDGELRLEQPFISAQTGLTYYALSYVRIPGLDAVLRFHQPVAAGEMAQEHQPAAATTLYEGYVDVQGTFQGQNICGWGVAERKHPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0JW69</accession>
    <name>R0JW69_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 10 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_91569</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 10 11"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027646.1">
        <property type="nucleotide sequence ID" value="XM_008029455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JW69"/>
    <dbReference type="SMR" id="R0JW69"/>
    <dbReference type="GeneID" id="19405912"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_0_1"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344072" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="41"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA85188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="231" mass="25611" checksum="44078D5BB52BAF15" modified="2013-06-26" version="1">MVSFKSLLLAAVATTSVFAAPFDFLAERDDGNATALLEKRQSTPSSEGYHNGYFYSWWTDGGGSAQYTMGEGSKYSVTWRNTGNFVGGKGWNPGNGRTINYGGSFNPQGNGYLAVYGWTRNPLVEYYVIESYGTYNPSSGAQRKGSFQTDGGTYDIATSTRYNQPSIDGTRTFQQYWSVRTQKRVGGSVNMQNHFNAWSRYGMNLGTHYYQIVATEGYQSSGNSEIYVQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWG5</accession>
    <name>R0JWG5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">OMP decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Uridine 5'-monophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_163968</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027726.1">
        <property type="nucleotide sequence ID" value="XM_008029535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWG5"/>
    <dbReference type="STRING" id="671987.R0JWG5"/>
    <dbReference type="GeneID" id="19398957"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030821_1_1_1"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000606">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="13">
        <location>
            <begin position="37"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA85298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="380" mass="42056" checksum="5807B4CE371CC8F8" modified="2013-06-26" version="1">MPSHASLTTTYRARAALPSVGPLASYLLSLIAAKHSNLCLSADVETSAELIQLAEDVGDSICLLKTHCDIVTDWSDRTAQALREIAVRKSFLIFEDRKFADIGETVQKQYTSGHHRIALWAEITNAHVLPGPAIVTALEKAAEKTIAKYNTSVNTEISATRQVNGADCDDDHDEAMENPNFSIESPIEMEGGERRLSIRPPNRKQSVVSVTTSISMRTESISPRPEPNHNTEDVFNLDTASELIRLGPPPFLRSLLLLAEMSSEGHLMTPDYQQKTVEIARNHRDFVMGFIAQRSLNTEPDDNFITMTPGCQLPPPGQEGKKLGDGLGQQYNTPRKLILDQGCDVIIVGRGIVRAHDRKSEAERYRQAAWAAYEERVQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0JX99</accession>
    <name>R0JX99_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylanase</fullName>
            <ecNumber evidence="7">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_161885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="KB908681">
        <property type="protein sequence ID" value="EOA85558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026812.1">
        <property type="nucleotide sequence ID" value="XM_008028621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JX99"/>
    <dbReference type="STRING" id="671987.R0JX99"/>
    <dbReference type="GeneID" id="19398221"/>
    <dbReference type="eggNOG" id="ENOG502QSCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_2_1_1"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344097" description="Beta-xylanase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="11">
        <location>
            <begin position="77"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA85558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="383" mass="40681" checksum="15A84E488CD2CF7A" modified="2013-06-26" version="1">MRTSVLALVVAPTVVLGQVPVYGQCGGSGWTGGTTCASGSVCTKINDFYSQCVPGSGAAPTTTNGGGGSSPAPTGGSGAAGGLHDKFKAKGKLYFGTEIDHYHLNNAPLTTIAKNSFGQITHENSLKWDATEPQRGSFTFSNADAVVNFATQNGKYLRGHTLLWHSQLPSWVTQINDRNTLTTVIQNHVTALVTRYKGKILQWDVVNEIFTENGNLRDSVFSRVLGEDFVGIAFRAARAADPNAKLYINDYNLDIANYAKVTTGMVEHVNKWVAQGIPIDGIGSQCHLAQPGGWNPASGVPNALKVLAGANVKEIAITELDIAGAAANDYLTVMNGCLAVSKCVGITVWGVSDKDSWRSSDRPLLFDNNYQPKAAYTALVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXM7</accession>
    <name>R0JXM7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_142324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
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    </evidence>
    <sequence length="441" mass="48463" checksum="2D833292D4151607" modified="2013-06-26" version="1">MVDWKGLFVKAYWTFAGLGMIWAVFIGSLISPTLQRHALYAHRFNTNFMDNISNPEEFGFAKGQVQPFRLTTADDENLFCWHVIPLDVYLENEHELSTAAAVGQTVDGLKGTVGEKLLSMDLESKVVVNFHGNAGHIAQGYRPSTYRSISGIPKTHLLTCDYRGFGISSLKNAPHIPTETGIITDAISLVSYVCHNLSHPVSRTVLLGQSLGTAVTAAAALYHTDPNSPELPHDLVRPRAPGSSTKAPKPPTETFAAIVLVAPFRTLPLLLQHYRISGLIPVLKPLQGYPRIANYLASRIVDQWPTQARLEALISSDAARKLGFRISLLHARNDQDISYFESESLFAPLQTLMLASGNAAADAAGSDVSAEETRRSVHGGERVKRGAFAYKKVEDSKGERLIELEVTRYGGHNEVVGWSQVALAVRRGFEKRRLRPGLDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZ23</accession>
    <name>R0JZ23_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_165949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030939.1">
        <property type="nucleotide sequence ID" value="XM_008032748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZ23"/>
    <dbReference type="STRING" id="671987.R0JZ23"/>
    <dbReference type="GeneID" id="19399640"/>
    <dbReference type="eggNOG" id="KOG4122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_1_0_1"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA81487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="122" mass="13607" checksum="59A8CCBA9B882D2B" modified="2013-06-26" version="1">MLLSRALALPLRRALSARQTLQRTRTQHMHTPTCGCVRPTLLSPRFASQRPPLIRELVSGFQGLGVSVSSSSSGASRMQTRGMKVRSSVKKLCDGCKSVRRKKGRYVYIICSKNPKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K038</accession>
    <name>R0K038_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_34596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030092.1">
        <property type="nucleotide sequence ID" value="XM_008031901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K038"/>
    <dbReference type="STRING" id="671987.R0K038"/>
    <dbReference type="GeneID" id="19403926"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_2_1_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA81822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="66289" checksum="8F5071064E2E4FF8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K085</accession>
    <name>R0K085_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_164561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028912.1">
        <property type="nucleotide sequence ID" value="XM_008030721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K085"/>
    <dbReference type="STRING" id="671987.R0K085"/>
    <dbReference type="GeneID" id="19399170"/>
    <dbReference type="eggNOG" id="KOG2866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041037_4_0_1"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="204"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="398"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA83089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="503" mass="56057" checksum="E7D9C1B8C3DEB8C8" modified="2013-06-26" version="1">MARLNTHLSATPQPRASTVDSLYRDPSVAPQSERNGRTSSYSVISPTRSMQSDKENEVPDTYKNTPRRGKAKGLRSASARMPTPDSGSTEGHGSKRRRTGNYDMSRSQRYDGEHEADEEDGIDTPSQSHLQPEPDEEGDLRFYNPNQDPEKRRRLRATMRDHQRMLDDNRDDLIKSRDSGLLDALRTQNSLFGKVRQTADATVDSRFLVNASDLAGKKLNNALGNSGVGIDLDQFVSKCIYFMKSGGYVAGEENAPTIPVGDDDDDDPDGLDWGLLGRKACFPCNKRPPTASFLLGPLSVQKRVRATQRKARSQAQAPGPVTRPQEIKEGDIQQNENNNLSNLVKGIRKRLIDHTSQGADRVESELSEIPESDLDEEAQAAAFRRHRMAMTTDGEPAVDLLDFAINPHDFGQTVENLFYISFLVREGNAKIVKDQDGLPLLVPAAPRGVSEQREENVQKHQAVFSLDYPTWQIFIDAFNIKEPLIPHRENEEANVGSTGWYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0S2</accession>
    <name>R0K0S2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_43968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030155.1">
        <property type="nucleotide sequence ID" value="XM_008031964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0S2"/>
    <dbReference type="STRING" id="671987.R0K0S2"/>
    <dbReference type="GeneID" id="19404886"/>
    <dbReference type="eggNOG" id="ENOG502QVDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_0_1_1"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA82032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="442" mass="49547" checksum="A03339AA278F8D02" modified="2013-06-26" version="1">MTIWRTVTIAEVARIVHFLKKHAVGKTIQAVKTQEDNIVYGKVGTSASAFQEAMSGKKIVDARQQGKYFWLVMDKPPHPVMHFGMSGWMKFSNDETAYYRPTKPEEAEWPPKYWKFILQLKEEPKNEVAFVDARRLARIRLVDAAAEDMRKTTPLKENGPDPVIDKDILTVEWLSKKLRSKKVPVKALLLDQANISGIGNWVGDEVMYQAKLHPEQYSNTFTDEQVKRLHDAIMYVCDTAVEANGDSDSFPENWLMKHRWGKGKKEGSKLPTGEKITFLKVGGRTSAIVPSIQKKTAAVAGDVSDDAEGGDNEEDTKPKKGNKRKAEDIKKENDEAEEEAPAKAKGGRKNAKKAAVKEEEAAAEEKLPAKPKRASKKVKEEVKEEVKAEAEEETTDEVEEKQPDKKRKTTANGTTKQKKTAAKAEKKSEDTGGKRRSGRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K175</accession>
    <name>R0K175_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_34885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030123.1">
        <property type="nucleotide sequence ID" value="XM_008031932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K175"/>
    <dbReference type="STRING" id="671987.R0K175"/>
    <dbReference type="GeneID" id="19403957"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_738027_0_0_1"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="375" mass="40864" checksum="DC52CAC898A75A92" modified="2013-06-26" version="1">MQVLRLRPDSSRGGGTSPLESPLLWQSTPDSVPGWPRSRLKRKSPSKRPCQPPWQSPWPRLSFTTYSNKVDDDPQLRPTPASPGSWQFCFAFTTYSAHAGADSGWSRCAHILKTSSPVLCVVGAGLSAPSGTATWRGTNGLSMGEHQGQGAGIAQEIPRRPRCRPNPAHDALAALASQHKDWLTVHQNVDGLLEQTSHPKSTLLSIHGNLRAVRCTVCDYHIHVEKPDDIPYLRALADLNNPPPSVALSDLPRCPTKCANLLRPRVVWFGEKLAANATDTVDEWIPAGHVDLVIAVGTSLEVFPAAEWVHTVRADGATLAIMDADEDHHPKDQEASDYGDCWHVPGDVAVTLSRILENFMLVTAEACEKDTTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1E5</accession>
    <name>R0K1E5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_163068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025518.1">
        <property type="nucleotide sequence ID" value="XM_008027327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1E5"/>
    <dbReference type="STRING" id="671987.R0K1E5"/>
    <dbReference type="GeneID" id="19398643"/>
    <dbReference type="eggNOG" id="ENOG502SUY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136928_0_0_1"/>
    <dbReference type="OrthoDB" id="3648350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343006" evidence="1">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="152" mass="15279" checksum="9F8159937288D48B" modified="2013-06-26" version="1">MLGRILVPFLAMQVLVSATPQQGRSASDVKITSLEQNGTSTQGIGNVAAAGNLTPFGGIGVGCGINWKADTSYGGGLQAGSKDFGLGGGFTIKPDSLEFSAGIGLNEAGVSANVQFAGGKDGSMQLSFNTSARIVCTPATEGQFTILTCKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0K228</accession>
    <name>R0K228_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_165005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029601.1">
        <property type="nucleotide sequence ID" value="XM_008031410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K228"/>
    <dbReference type="STRING" id="671987.R0K228"/>
    <dbReference type="GeneID" id="19399326"/>
    <dbReference type="eggNOG" id="ENOG502QQV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:methionine biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
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        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="184"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="406" mass="46228" checksum="6C556E587356A93E" modified="2013-06-26" version="1">MASLKRSPPFRAEHVGSLLRPQELVQKRYDVASGKSQPEELVPLEDKAVAEVVKFQQDCGLKVVSSGEYTRHMFWGTFFETLHGMKELQLGVLKGYTKDMFRAYAPDVKSFMEAKEVPNHVTVCVDKIRHPGKSSNQREVDLMKSLLPESEWKNIKITLISPSWYHFRYMNGSAYPKEVYANDEEYFEDVAKAYQEELKILHSQGIRNIQIDDPNLAYFCSQDMLAGWKADSVNNKTADEMFDSYVKFYNKCFERPADMHLGIHLCRGNYVGSRHFSEGAYDNIAKKLFQDLNVDTYYLEYDTPRAGGFEPLAHLPKNKNVVLGVITSKFPTLEDKDEMISRVNQAADWIAKGTGQSREDALQQCCVSPQCGFASHAEGNALGYEDMRKKLQLVRSIADAVWPGQP</sequence>
</entry>
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    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_34467</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="R0K3I9"/>
    <dbReference type="GeneID" id="19403911"/>
    <dbReference type="eggNOG" id="ENOG502QPYR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026803_0_0_1"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13449">
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    </dbReference>
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        <property type="entry name" value="YWTD domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytase-like" evidence="1">
        <location>
            <begin position="65"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="497" mass="53962" checksum="51515DB947E1B264" modified="2013-06-26" version="1">MDKKTYKSAYATTQCGNSSSSANLSTSQSIASDARDKFGDTIGGLGSAIAFDKKSWKYKNGAYQGLVWGLPDRGWNTQGTQNTQTRIHKFSASFTPVKATLADPASPNLQLSYLDTLLLTGPDGTPLTGLDPTDTITYPGFPDLPLATYVGNGFGQNGTGGARVALDTEGLVLGDDGTFWISDEYAAYIYQFDSNGKMTKAVRTPDAFIPRRNGADSFSADSPPIYDPDFEITPKDPTSGRGNNQGLEALTASPDGKYLYTMLQSATIQDGGSSSKKRRNTRLLKYRVKDEKTTLEADYVVQLPVLSTGRVASQSEMHYISETQFLVLARDSNAGQGAEKTESIYRNADVIDISNATNVFGTAADSFGGQIASKDGVLKSGIVPVTYCPWLSYNNNNELGKFGLHNGGEQDSKLLNEKWESFAMLPVDKDDKIGWSDRQNEDEGKQYYLVSFSDNDFITQNGYINFGQNKYVDASGNNIDTQVLVFKANIPKGANPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3R5</accession>
    <name>R0K3R5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_28033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">28A</strain>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA87728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K3R5"/>
    <dbReference type="STRING" id="671987.R0K3R5"/>
    <dbReference type="GeneID" id="19403199"/>
    <dbReference type="eggNOG" id="KOG2135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017928_1_0_1"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
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</entry>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908548">
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    </dbReference>
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    </dbReference>
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            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
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            <fullName evidence="4">NAD(P)-binding protein</fullName>
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        <name evidence="2" type="ORF">SETTUDRAFT_138378</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
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    <dbReference type="eggNOG" id="KOG1611">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45458">
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        <property type="entry name" value="adh_short"/>
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        <property type="entry name" value="ADH_SHORT"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25385" checksum="AA085A9CFA488E30" modified="2013-06-26" version="1">MATYFLTGANRGIGLEFVRQLAAKPTNTIIAGVRSKSADLSDLHALNTHNNVHIVECDVSSLESLAGIEFRVAEILSKTGSNLDFLFNVAGINATSSDTSLTLDPKSISAHMQTNVVGPAKIVQSLKRYLARNATVLNMTSGLGSLAVATDMTKCCSYSMSKAALNMLTVHQSKDLKGNGVKVICMDPGWVKTRMGGEGALIEAQRSVKKMLRVVEGLKEADSGKFYRYDGEIVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6S9</accession>
    <name>R0K6S9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_148066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023386.1">
        <property type="nucleotide sequence ID" value="XM_008025195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6S9"/>
    <dbReference type="STRING" id="671987.R0K6S9"/>
    <dbReference type="GeneID" id="19396952"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37845" checksum="88C74FA1CF34CF66" modified="2013-06-26" version="1">MDSDSDSDPDSDADQATIHDSSSDSGFDSGSLLGDETDSLASSILNHRMENGRQYHAYRDGAYWGPNDELAKEILDFAHHMYLLTLDQKLHLAPLHHPHAILDCGTGTGIWAIDMADQYPEATVTGTDLSPIQPEWVPPNCHFEIDDVSLEWTFPPDHFDFVHIRELFGCIPDWDFFFAQAFRHTKPGGWIEIVEHSVCPVADDETMGPDHFYHTWGHVVVDMGNKFGKSFTIWEESADRIRKAGFVDVTVVDFKWPMNGWPTNAKLKNIGRWNQLRLMDGVEGFMLRLLTQVGGWSVARAQLHLAQMRKELKSYKAHAYLPGTVVYARKPFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA38</accession>
    <name>R0KA38_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_26168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022420.1">
        <property type="nucleotide sequence ID" value="XM_008024229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KA38"/>
    <dbReference type="STRING" id="671987.R0KA38"/>
    <dbReference type="GeneID" id="19402985"/>
    <dbReference type="eggNOG" id="ENOG502R3N6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007899_1_0_1"/>
    <dbReference type="OrthoDB" id="3199516at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55008" checksum="B6577857616A7CB5" modified="2013-06-26" version="1">MRHSEEPLSQKPGAAGITERSVEATPMKTTVSQPLPSIASLSLHEREADQDVDHFGNPMDDSSMTEGVSVFDNQPVGVEQAPHSAHPDKSNLKSHPMHSLHEQSTHEQDSLQHAAEPLLTGKLKLEVLELERVPLSVPVLRRAFDWSMLSTLTLLHCSNHEQLWKTLRRAYTPRPPYPGSPSSSKAYKASYTLRSEYQLNLKRIHTNTVSPSLISFLKETLAPNSLEVLFLQEGRSYSSTVTVDAIYKGPLKRHRASLKKLMIDSGEKGPDGHTTTSSRWRRWMLNREILTFITSGRMNSLRELAVSIDYKDWHHFLQRLPYIPHIRSLYIPFIADHAHGSNIDPRELAYQILDIVHLRPEIELCYMGLSNKCFEILENRPSNYDLRHDGMHADGSGSAYATHDPMLSDDESEATEDDDEDSMDEGAAPNGSDDTESDVSDEADAESDDESFIQDSQKGPKLRVREILFYEERVEAFRRRHGVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAY6</accession>
    <name>R0KAY6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_164054</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027810.1">
        <property type="nucleotide sequence ID" value="XM_008029619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAY6"/>
    <dbReference type="STRING" id="671987.R0KAY6"/>
    <dbReference type="GeneID" id="19398984"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA85412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="311" mass="32274" checksum="0983802B0B098B0D" modified="2013-06-26" version="1">MAFTPRGGRGGGRGGGDRGGRGGFTPRGGRGGGRGGGGDRGRGGARGGRGAPRGRGGARSGARGGARGGAKVIVEPHRHAGVFVARGKEDLLVTKNLTPGESVYGEKRISVGASAAKDGETEASSTEYRVWNPFRSKLAAGILGGVDNIYMGPGSKVLYLGAASGTSVSHVADIVGPEGTVFAVEFSHRSGRDLINMATHRTNVIPIVEDARHPSKYRMLLGMVDCIFADVAQPDQARIVGLNAGMFLKVGGGIVISIKANCIDSTAAPEAVFAQEVAKLREMGIKPKEQLTLEPFERDHAMVVGVYQRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0KC18</accession>
    <name>R0KC18_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_102661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022313.1">
        <property type="nucleotide sequence ID" value="XM_008024122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KC18"/>
    <dbReference type="STRING" id="671987.R0KC18"/>
    <dbReference type="GeneID" id="19394938"/>
    <dbReference type="eggNOG" id="ENOG502S054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079417_0_2_1"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="196" mass="22516" checksum="4344BED675648E05" modified="2013-06-26" version="1">MSTISEVITKDHRELEQYYNEVINSDDVDHQTRFGNQFTWELARHSVAEELLVYPAMEKYVGKEGHEHAEKDRKQHHQVKEFLKEFQNMKATDSNYVPKLKELWTFLGEHIKEEERDDLPILEKALSSPENKGASESLAKNFGRTKMLVPSRSHPSAGENPLFEGPMGMLAAPIDHIADIFRKFPEGTINPNPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCW0</accession>
    <name>R0KCW0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_89201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025660.1">
        <property type="nucleotide sequence ID" value="XM_008027469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCW0"/>
    <dbReference type="STRING" id="671987.R0KCW0"/>
    <dbReference type="GeneID" id="19405760"/>
    <dbReference type="eggNOG" id="ENOG502S48Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092522_0_1_1"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="179" mass="19581" checksum="32D98B6489D8F70E" modified="2013-06-26" version="1">MPSSLPPTSALPHLATPDLTKVLDVLFEPSSTLHSLSLPVLRSAPFPDYPTLISAVTAQLSALASSTQPQDAQRLDQILGAHPRLGAKKVDSELSQKEQAQLHAGHDDQGRMLDALNAEYEAKFPGLRYVVFVNGRPRPQIMQNMRARIDRGDAKAERLEAIQAMCDIALDRASKLHTE</sequence>
</entry>
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    <accession>R0KDI0</accession>
    <name>R0KDI0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_161427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026205.1">
        <property type="nucleotide sequence ID" value="XM_008028014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDI0"/>
    <dbReference type="STRING" id="671987.R0KDI0"/>
    <dbReference type="GeneID" id="19398153"/>
    <dbReference type="eggNOG" id="ENOG502RAAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="191" mass="20751" checksum="0BBFE961ABA0A891" modified="2013-06-26" version="1">MASYSFYDVTVPVLRNISKSAISFLTAAKEEISKNSSLPSEQELLDAKIGDMLPFRMQPILVASFPVGAINALQLNGSATTPALDPASFSSLDDIINFFKQMLTVYDAIDAKTYNESAEKSFQVSVGPKTLNASSLTSFIGDFVIPNSFFHLNAMYMLLRGKGFNLGKPSYIGAFMGETSQKDWAAMRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDQ6</accession>
    <name>R0KDQ6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_166867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDQ6"/>
    <dbReference type="GeneID" id="19399960"/>
    <dbReference type="HOGENOM" id="CLU_1866368_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="137" mass="15310" checksum="08E794A0FC479458" modified="2013-06-26" version="1">MRSVRDTTDPGNKNAGHCAGSEGSSSTLRRTVCHPQSKCPDWRKNRTQAGRERVTDNSPARCGNIVLIENTNRALPRAPNVSMLLSFSYNAHAMQRAAGRRPIRFDRHTTHGLEPQNIDTFWYDTHRPCAQKLPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KE35</accession>
    <name>R0KE35_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_161115</name>
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    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024803.1">
        <property type="nucleotide sequence ID" value="XM_008026612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KE35"/>
    <dbReference type="STRING" id="671987.R0KE35"/>
    <dbReference type="GeneID" id="19398115"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Grimwood J."/>
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                <person name="Xue C."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">28A</strain>
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    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="GH2_Domain-Containing"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Grimwood J."/>
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                <person name="Xue C."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="618"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="687"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1016"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129163" checksum="60F2920C58E38E8C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJR9</accession>
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            <fullName evidence="4">Tat pathway signal sequence protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_59298</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJR9"/>
    <dbReference type="GeneID" id="19405247"/>
    <dbReference type="eggNOG" id="ENOG502SRWG">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21987" checksum="E87882ACA46F1B89" modified="2013-06-26" version="1" fragment="single">PLKHAIEYEYRVFEDIPIQFHNGTLNPKKPTNFGGKPRPALDAAWRKLTKNQNIYLTEKDLGQPIEDDTVIQLTDGSGAFATLTVYHGLHCMERLHHYLYPEHYYSSFSDDEKLLLKYHAEHCLNWLRQYLTCNADTTPIMMHWIAESALPIAKVDGGSHSCVNWDRIDEWAEKRTFVPSGDNMKHPIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKJ5</accession>
    <name>R0KKJ5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_27306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025519.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0KKJ5"/>
    <dbReference type="GeneID" id="19403112"/>
    <dbReference type="HOGENOM" id="CLU_039641_0_0_1"/>
    <dbReference type="OrthoDB" id="3679872at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="359" mass="40867" checksum="72FC609DC45EC2C4" modified="2013-06-26" version="1">MSELAQLALKNDLFLAFGLELILHLWPLRDCFDAVVQRKLLPERFQSAYGSETAIAQTNAIRPKPTMLTRTTTKTVARTLYNTVTEQVTSVSTVTDRHWLTKWTHFPIDPATPCVTWTYYTNTTAVPEQNHTFTPPPDNSTDTHPTTPTATWSSTSWLLPSLLALTSTTLLLLLLVLLLKPHLLIPRPRSANPQTQQKLYQDWKDRAYSVLSDLEQTQRETQRLKQGISTRTAMLELLLGKNLNSDAAMSTTTDDHDDEEEEEEEILHHLVTQKRETDAKTQTQLHTATASNSALLARIQHLEGHNAELRDTIRMRLNSHFVPGVDQSFQELLDEKQKEIAFWRAAFYRERGEEEGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0KL04</accession>
    <name>R0KL04_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_147033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022747.1">
        <property type="nucleotide sequence ID" value="XM_008024556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KL04"/>
    <dbReference type="STRING" id="671987.R0KL04"/>
    <dbReference type="GeneID" id="19396898"/>
    <dbReference type="eggNOG" id="KOG0740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_15_1_1"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="558" mass="59486" checksum="ECBD22417E0B8DF1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNZ8</accession>
    <name>R0KNZ8_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_175630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022587.1">
        <property type="nucleotide sequence ID" value="XM_008024396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNZ8"/>
    <dbReference type="STRING" id="671987.R0KNZ8"/>
    <dbReference type="GeneID" id="19401411"/>
    <dbReference type="eggNOG" id="ENOG502ST5Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355674_0_0_1"/>
    <dbReference type="OrthoDB" id="5428038at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="788" mass="88048" checksum="B69221BB2B0B0CE2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQ89</accession>
    <name>R0KQ89_EXST2</name>
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        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_166971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA91179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQ89"/>
    <dbReference type="STRING" id="671987.R0KQ89"/>
    <dbReference type="GeneID" id="19400000"/>
    <dbReference type="eggNOG" id="KOG0781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_8_1_1"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000023">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA91179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="641" mass="69111" checksum="91374B4FBD12B717" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSV7</accession>
    <name>R0KSV7_EXST2</name>
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        <recommendedName>
            <fullName evidence="15">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_178369</name>
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    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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    <sequence length="309" mass="34016" checksum="5CB38A6D2841939C" modified="2013-06-26" version="1">MQSSLNSWLKKASLDKQLPQSQPPRPSQPPQNGLPSMPPKANRPPPPPKSASAPPRAPPTTTPTPAAMENWNDIPDDFLQAPSRPRAKKSPRSSRAVTPVSGMPTPILPPVESLAIPQLFALRPLPPNVQLVPLTEELLPAFKRLNTLTLPISYPESFYNETMTEPHHGITLVAVWRPAPVNEAEAASSDQPHLVGAVRCRLLPSSQLYISTLGVLAPYRAHGIAMHLLQAIVKKAVELHSVRSVTAHVWEANEEGMEWYKKRNFDILGKEEGYYRKLRPQGAFLVRKWIGVGDLLGNGLTQDDVLSSK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="662" mass="71810" checksum="89FE8C71BC1D3A9C" modified="2013-06-26" version="1"> </sequence>
</entry>
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    <accession>R0KVD1</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020801.1">
        <property type="nucleotide sequence ID" value="XM_008022610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KVD1"/>
    <dbReference type="GeneID" id="19398353"/>
    <dbReference type="HOGENOM" id="CLU_2759411_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="70" mass="7526" checksum="D04B2F11EEDCC75C" modified="2013-06-26" version="1">MSSALARCFTCHPSVPALPLPSCNLPVHAVQQVIRRGFEFQGMTKAGPLSMMTTAPFFVETNARSGFGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0I5R0</accession>
    <name>R0I5R0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_81368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="463" mass="49392" checksum="ABC95B9497608207" modified="2013-06-26" version="1" fragment="single">MPQWGRPPGGSSGVGRYYEGVVDDVYRFQDLGSDEEELDGVVIDGVLQPALNGKRINPDELYFNDMDIRAWESRTSALEEPTHGRVHGRRGYQEEHFGGAGNTIPSAETEERLFQRVLDKIRVARAAGNTDVSLSAEELDAYQSRLYGARASAVRPEPEPRPTSVSVSASTSASASVPNDTASVMSYETTGKHGASSSRSKKSQPRTSMFGSKAKKERRHSGHRRTSTNSTTESHALAPGFVVPGADGQGIYAPINAYEGSLARDQRPLRAASRRASDTSHHAAAAPNDTSPRNMLGSFPESEYDYGPSTPAWEEQKSVSRPSVDSASVPLGSRSGPPSIASSRLVPFPVEPYQYHQFSTSSSSLSPTSPQPQYTRRMSLSPSEASYTSVPRRIPAASPGYPPVPVPLQRVTDGGTGQGRASDPPLGTQSYGAGVPVQGQQSATGSGSGRGGEKRRSGGKGRK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="30"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA81280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31317" checksum="34AAC58E13E8065D" modified="2013-06-26" version="1">MTSPELEAFARALSRVLGWAYFLAWSLSFYPQPISNYVRKSTLGLAIDFPTLNVLGFACYTVSTASFLYSPTIKTQYAQRHPDAPQTTVRFNDFLFAAHGAVMCVIIYSQFFESIWGFEVGRRQRVSRAILGVWWACVVAVLGVVVLVRVQGVHGGYSAEGWAWIDVIYTLGYVKLLTVILKYIPQAWVNYKRKSTQGWSIYPMLLDFAGGWLSLAQLCIDSALENDWSGVTGNPVKFGLGNVTIVFDVIFMLQHYVLYRHTSEKTMDEDEERGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Uncharacterized protein</fullName>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I7C1"/>
    <dbReference type="STRING" id="671987.R0I7C1"/>
    <dbReference type="GeneID" id="19406404"/>
    <dbReference type="eggNOG" id="ENOG502SDAI">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="3692311at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA81460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="324" mass="34343" checksum="B794AA149DFC4627" modified="2013-06-26" version="1">MANASFYDFHCPTGGKWYACAKGSNFVGCCTSNPCTNGCVQGDVRAGGYNITHHGEWPDASCGSASDFYTCNAGPSFWGCCKSNPCAATPPSVCPDGDLVPAFMERPEQFNVYTSSKVENPESTSSDSKTNTGAIVGGVVGGVVVLLIIAVIIFVVLRRRRRNRKTTDGNMGAAAMMPMMNNEKDDNNNNNTAPAHYGGQSPPPTYSAPIQNSYQATAPGKGHESYHQYASHASEPQELPTDTSSSNPNRFSELPADASTSGVNRRFSELPAEGTARGGPSELESPLASPYVTPALLQEEFTNDMAKRASHHGLGLSPVTGRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9Y5</accession>
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            <fullName evidence="11">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">SETTUDRAFT_60790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
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    <dbReference type="GeneID" id="19405260"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Conidial pigment biosynthesis oxidase Abr1/brown 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase_2nd"/>
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        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
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        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342960" description="Multicopper oxidase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="68"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
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            <end position="341"/>
        </location>
    </feature>
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        <location>
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            <end position="592"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA82285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68098" checksum="C4307AB7CD99262B" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAJ5</accession>
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            <shortName evidence="7">CHT</shortName>
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        <alternativeName>
            <fullName evidence="7">Cyanide-degrading nitrilase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Formamide hydrolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_165747</name>
    </gene>
    <organism evidence="10 11">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>formamide = hydrogen cyanide + H2O</text>
            <dbReference type="Rhea" id="RHEA:21720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="EC" id="4.2.1.66"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer of dimers, forming left-handed helical fibers.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By cyanide.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.66" evidence="2 7"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030580.1">
        <property type="nucleotide sequence ID" value="XM_008032389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAJ5"/>
    <dbReference type="STRING" id="671987.R0IAJ5"/>
    <dbReference type="GeneID" id="19399575"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030196">
        <property type="term" value="F:cyanide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019500">
        <property type="term" value="P:cyanide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03224">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037544">
        <property type="entry name" value="CN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF4">
        <property type="entry name" value="CYANIDE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA82341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="365" mass="40951" checksum="F2133E941670D93B" modified="2013-06-26" version="1">MPLTKYKAAAVTSEPCWFDLEAGVQKTINFIKEAGEAGCKLIAFPEVWIPGYPYWMWKVNYQQSLPMLKKYRENSLPIDSEEFRRIRRAARDNQIYVSLGFSEIDHATLYLTQTLIDPTGEVINHRRKIKPTHVEKLVYGDGAGDTFKSVTQTELGRLGQLNCWENMNPFLKSLNVSEGEQIHIAAWPVYPGKETLKYPDPATNVADPASDLVTPAYAIETGTWTLAPFQRLSVEGLKKNTPEGVEPETDPTTYNGHARIYKPDGTLVSKPDKDFDGLLFVDIDLNECHLTKALADFSGHYMRPDLIRLLVDTRRKELITEADPHGGIQAYSTRERLGLDAPLDGHVQKQKRGVAADESTSATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAN9</accession>
    <name>R0IAN9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_164959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029542.1">
        <property type="nucleotide sequence ID" value="XM_008031351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAN9"/>
    <dbReference type="STRING" id="671987.R0IAN9"/>
    <dbReference type="GeneID" id="19399309"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019916_1_0_1"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="444" mass="50729" checksum="1496246B05D15AF0" modified="2013-06-26" version="1">MANVEIALPLPVLPEGWAAEKDFKAIGQLSEANDRNIEPVGPHFLAYARRKRHKRTFSEDDRIQAQANVKSVEEEDPDDVDEPEDPLMLQREAKDWKSQDHYAVLGITRYRWRATDDQIKRAHRRKVLKHHPDKKAAKGGTEDDQFFKCIQKAHEVLSDPVKRRQFDSVDEGAEVEPPSKKESQKGNFYKLWGKVFEAEGRFSNLQPVPKLGNENSTKEEVEHFYNFWYNFDSWRTFEYLDEDVPDDNENRDQKRHVERKNQAARRKKKTEDTARLRHLVDDCLALDERIKKFRQAEHAQKNKRRLEKEAALKREAEEAEKRKAEEAKAAAEKEAAEKAAKADSKKAKEAAKNAAKKNKRVVRGAAKDANYFHSGGEAPAAQVDAALADVDLIITKQDHEELAALTGKLNNVKDAGKIKDIFQEEAQRLIGAGKLAPGELRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAQ2</accession>
    <name>R0IAQ2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_64031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029526.1">
        <property type="nucleotide sequence ID" value="XM_008031335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAQ2"/>
    <dbReference type="STRING" id="671987.R0IAQ2"/>
    <dbReference type="GeneID" id="19405300"/>
    <dbReference type="eggNOG" id="KOG3085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23209" checksum="06CD78B1FEFB03D0" modified="2013-06-26" version="1" fragment="single">DLLLCFDAFGTLFAPSIPIPIAYARAAAHHGIRIGNTQDVGTSFKLAFKQESQRNPNYGKSSGLGSEKWWANIIHATFTPFLRKDQPFPHALTTELLDIYSSSRGYTLFPDVTPFFSTLRALKQQRIRETDDWPWHNTVVGIVTNSDDRVPGILESLGLSIGPRRVGTKDNRDKEASSHDDISFVVLSYDVGVEKPHSGMFRAAEDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICA2</accession>
    <name>R0ICA2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_165228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029839.1">
        <property type="nucleotide sequence ID" value="XM_008031648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ICA2"/>
    <dbReference type="STRING" id="671987.R0ICA2"/>
    <dbReference type="GeneID" id="19399395"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143122_2_1_1"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA82841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="77" mass="8783" checksum="4850AD39329D4D21" modified="2013-06-26" version="1">MIVPIRCFSCGKVTGDLWEKYMSLLSDGMEEAEALDSVGLQRYCCRRMILTHVDLIEKLLKYNASEREQARAARGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0IFG6</accession>
    <name>R0IFG6_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_32833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="54"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA84326.1"/>
        </source>
    </evidence>
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        <source>
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</entry>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name type="synonym">Setosphaeria turcica</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_442887_0_0_1"/>
    <dbReference type="OrthoDB" id="3799281at2759"/>
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    </dbReference>
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        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="516" mass="58975" checksum="2D6307C864FFB56D" modified="2013-06-26" version="1"> </sequence>
</entry>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502S72R">
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    <dbReference type="HOGENOM" id="CLU_046437_1_0_1"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0000444">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44987" checksum="F7377CBBFD57F959" modified="2013-06-26" version="1">MMASAKQQENMLLTEHFSWPPISLIDDIINAVNEVLYRCTDSFEAGLTSADPALLGFADLYASQKRTPATDEDGQNAYPEAALEIEEGVLKLETLMENAVDKNFDKLEIWTLRNVFALGRGKGEDEGLGDWVRLLHYENLQAPPKDSNLTPEALYALRRKLVETQKLHAALVAEKTRNEAQIARLKALLEPPRSSTLLSAEVQNGTGKIQQEGGEEEEEEEEGEGAFAFLVNTPAAQALGIQVPSSSSSSTGTTKPLATHTAFTTTQLPYLRHLLASLKPHLSTTALPHNSNSSTSTSTSDAKDTSTQRKLYVESQTKRVLERRGIDTRDGVEGVWHGERVAADEVRALEALVAGFGRGGNANANGKGKAGGGKRGNEEKEGEGDVQMDMDMEMEMEDEGGEGDEPEPEAMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_179912</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027858.1">
        <property type="nucleotide sequence ID" value="XM_008029667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IKV1"/>
    <dbReference type="STRING" id="671987.R0IKV1"/>
    <dbReference type="GeneID" id="19401724"/>
    <dbReference type="eggNOG" id="KOG2737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="33"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="667"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="733"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA85486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="847" mass="93651" checksum="AC678410FD16D5AE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0IM65</accession>
    <name>R0IM65_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_169490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026475.1">
        <property type="nucleotide sequence ID" value="XM_008028284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IM65"/>
    <dbReference type="GeneID" id="19400923"/>
    <dbReference type="eggNOG" id="ENOG502RMXS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107689_0_0_1"/>
    <dbReference type="OrthoDB" id="4968544at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="251" mass="27957" checksum="CE11C5AFB605A3B8" modified="2013-06-26" version="1">MSNQIVLERDGKHLLMQKLVPPDTTTPAIDDLLSFSSPFNQAFGSNVLLLVPTENQFKTKVLENIIEQDLQGATLITRQLKVDTGIEQPYDEKFEDCVIKRLKGAFAFLECNPDFLGENSIGRVEIGVIENYIRLSDGDSSAVDFGSIIIHNATIGKTRCSVSRGVTVQMEYVKEARERGFVDPEEKGGICTVGNVLKNHFDQVARHKFGGDYDISKDWHLAVSGESRYALLEEAARKVYATAIQECIRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0IMK9</accession>
    <name>R0IMK9_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_47648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026281.1">
        <property type="nucleotide sequence ID" value="XM_008028090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IMK9"/>
    <dbReference type="STRING" id="671987.R0IMK9"/>
    <dbReference type="GeneID" id="19405147"/>
    <dbReference type="eggNOG" id="KOG0098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001537">
        <property type="entry name" value="Secretion related GTPase SrgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="260" mass="27966" checksum="4B51D406F57CF6F3" modified="2013-06-26" version="1">MAQPWDYIAKIVSLGDSGCGKSSLTVRLCEGRFSPHHDVTIGVEFGSRIVPVGPPASYALNINNPAKTSQAPAPVSPSKQKQEQKHMKLSLWDTAGQETYKSITRSYFRGASGALLVFDISRKNTFLSATSWLHDLRQIAEEGIVVVLVGNKSDLAGSSTVSGSEAANKRQVTREEAEEWCKANGVMQYVETSAKSGEGVERAFLEVAERIYQNIEAGKYDLNDRRSGVKGPGGGGANRAGINLNDASRKGKQQGWGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0INP4</accession>
    <name>R0INP4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_41182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025101.1">
        <property type="nucleotide sequence ID" value="XM_008026910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0INP4"/>
    <dbReference type="STRING" id="671987.R0INP4"/>
    <dbReference type="GeneID" id="19404678"/>
    <dbReference type="eggNOG" id="ENOG502SZXU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041463_0_0_1"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="507" mass="58700" checksum="8C65375367B166BA" modified="2013-06-26" version="1">MTIINEHDFPPLPRTDAKQKEADEICRLREQEPGTTLHDLPDELILEISEHLRRMERKLHRARTLLNFALTSRRLYRIITEMVYARFSNTYGEPYLFLRTMISNPQLARLVRDVDITIEYETRAVGPHTPTAQDKKVIKEGLRALDIPYWKDCATDCYGSTEKDHGVMRNSTILLFTPNVTSIRIECSYEYETPCPVWVAFISRAVMGRFGNAHGFERLRSITIVMSLTDVIAVSPLFHIQSLRTLQLHRVRECSEYDDQLQPNYDEENIRKIQRLIPQACNNLEELVVENIFYTEDCLEALIASSRRLKVFKTRAATSNLLPESRRLPTSKSKTVIGMLGRHKTSLETLHVDRDDETDRDFPDKAHVRNNMKAFTSLKELSCPLAAIMTGKKDRFVERLPPSLVTFRTHFRNRTCDLDWIGGLEHMLANYEAHIPQLCELRVETPYYSQSEYKETVKRLARPSAKAGIVFSHAIRHYEYWHDPEDTVSESSESSDDVSMSSDEDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPG9</accession>
    <name>R0IPG9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_153422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025263.1">
        <property type="nucleotide sequence ID" value="XM_008027072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPG9"/>
    <dbReference type="STRING" id="671987.R0IPG9"/>
    <dbReference type="GeneID" id="19397298"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_2_0_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA86616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="388" mass="41752" checksum="F912BFB398435394" modified="2013-06-26" version="1">MIPTNFANAINVVIQSAALAAQPPAPSVSTLLGTAPRLAASIKASFPNPNLALLPQPIWWWQSGTAVEALLTYTSVTGDHQYEPILQNTILSQATPGDDFLTVDATGNDDQAWWALAAATAAEVKLPDTNPNATWLDLARNVYEQQKARWGNEKKGSGGCKGGLGWKIAKGDGNDGFFYKNSISNGLLFQLAARVAQLSAVQNETAAAEMSAWANTVYDWSVQVGLVNDQFDVFDGTDEKNGCADLNHNQWSYNVGVYMYGSAVMAVQTGDAKWVQRTRGFIQSANRTFVNHDTGALWEATCEKDKSCDADQISFKGLLARWLGATAEILPQVSLDAKAIGTMDGLGPIDSFNALELMCASLKTQEVQGDEGGMIGLRRARRGVARQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPR8</accession>
    <name>R0IPR8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_87464</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025324.1">
        <property type="nucleotide sequence ID" value="XM_008027133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPR8"/>
    <dbReference type="STRING" id="671987.R0IPR8"/>
    <dbReference type="GeneID" id="19405651"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_1_1"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343235" description="Dipeptidyl-peptidase V" evidence="10">
        <location>
            <begin position="18"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="494"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA86701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="716" mass="79118" checksum="25316CB759419E9E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRK0</accession>
    <name>R0IRK0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_136026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025756.1">
        <property type="nucleotide sequence ID" value="XM_008027565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IRK0"/>
    <dbReference type="STRING" id="671987.R0IRK0"/>
    <dbReference type="GeneID" id="19396338"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075838_2_0_1"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF117">
        <property type="entry name" value="ZINC FINGER PROTEIN WECKLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA87316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="227" mass="26844" checksum="B1DD17B03F1CC2E2" modified="2013-06-26" version="1">MAILRSYRWCDRCDRTYRTFSALRQHIKDSQNHYECPGCDFDGESWDDLLQHCRDEGCRTVCQGCNHGGGSHWDRDCEEYWHHLSDFNVCQRCERHFTSPDHLHNHMLSHRVPMYECYLCTDVFKTYGGMIIHLEYGTCSNVDRIELNMLAARCMRWRHFIDEDYRNELLAYGDTQYDVDPFMCPTCDATFSKLSGLFQHVESSACEQNLHDRVIGKLRNFLASRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRM7</accession>
    <name>R0IRM7_EXST2</name>
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            <fullName evidence="6">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
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        <name type="common">Northern leaf blight fungus</name>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025781.1">
        <property type="nucleotide sequence ID" value="XM_008027590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IRM7"/>
    <dbReference type="STRING" id="671987.R0IRM7"/>
    <dbReference type="GeneID" id="19398731"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_4_0_1"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
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    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
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    </dbReference>
    <dbReference type="Pfam" id="PF01655">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA87346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14736" checksum="A4093A26B6497ED5" modified="2013-06-26" version="1">MVAAKKHVPIVKKHTKRFNRHQSDRFKCVDPSWRKPKGIDSAVRRRFKGRAAMPKIGYGSNKKTRHMMPSGHKAFVVNNVADVDLLLMHNSTFAAEIAHAVSARKRIDIIARAKQLGVKVTNGKARVKTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVQ4</accession>
    <name>R0IVQ4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_27472</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVQ4"/>
    <dbReference type="GeneID" id="19403132"/>
    <dbReference type="HOGENOM" id="CLU_2721855_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342539" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="74" mass="8305" checksum="4E2683CE9CDCFB2E" modified="2013-06-26" version="1">MKLPILVLAVLVALAAANDKDKKFVVRNCHDCKKYYEKCHFNCYYGGSTCDGTCRTDTCRQSSLCKEHCGYGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVY4</accession>
    <name>R0IVY4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_106119</name>
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    <organism evidence="1 2">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023443.1">
        <property type="nucleotide sequence ID" value="XM_008025252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVY4"/>
    <dbReference type="GeneID" id="19395149"/>
    <dbReference type="HOGENOM" id="CLU_3038174_0_0_1"/>
    <dbReference type="OrthoDB" id="3938460at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA88771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="55" mass="6508" checksum="D5C9B9128E09B1C2" modified="2013-06-26" version="1" fragment="single">HPNHLISRLGKAIAKERTKANLGAKYSLYFKLLHKKINEYNIQPINIFNIDKKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVZ7</accession>
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            <fullName evidence="5">Translocation protein sec66</fullName>
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        <name evidence="3" type="ORF">SETTUDRAFT_27014</name>
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    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023300.1">
        <property type="nucleotide sequence ID" value="XM_008025109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVZ7"/>
    <dbReference type="STRING" id="671987.R0IVZ7"/>
    <dbReference type="GeneID" id="19403079"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24053" checksum="BEEDF54512E9D986" modified="2013-06-26" version="1">MWPFDLVDWVMLTVPIAYIGVLAGSFGVFTNLYKKRQAANAASLEPWFPTHLQRNVYLSLLHMDEPKVPDSILKAALLRRATEDIHRIIQIRNAKQALQVLLQRGSVGDDLWQRFQRAEQEIEEELRDVVNEANAFAPNWGQTIFQSASEMAQNNHIRERLAEIEAKAPAEKAWWESRRAGIQSEFMKELDDEKAKSEEDAVMVEKAKH</sequence>
</entry>
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    <accession>R0IWD6</accession>
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        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_27135</name>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mug57-like"/>
    </dbReference>
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        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
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        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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    <feature type="chain" id="PRO_5004353290" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="58"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA89080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="206" mass="22589" checksum="1C394834B56E5F36" modified="2013-06-26" version="1">MKAQSLFTYPLATITLIFACSAESRPFDSIVQSLHAITAQSPLRDYIMSKPEGQVSTGVIISDVIGKTQEIAIFSGLTRDIDSVSGRLDDAAQNATVLAPHNSVMRDLKRKPWEDADDYKTLGDNAYAGASGEDRARTNLERFVQRHIVPESPWEEGKKVKTLAGNEVWWESKDGQKKIQPANIEVTSIADKVSNGEVWVLGGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IWP0</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_27068</name>
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    <organism evidence="4 5">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IWP0"/>
    <dbReference type="GeneID" id="19403085"/>
    <dbReference type="HOGENOM" id="CLU_066286_0_0_1"/>
    <dbReference type="OrthoDB" id="3689183at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
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        <property type="match status" value="1"/>
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    <sequence length="355" mass="39694" checksum="EAFCD51ADE0EE758" modified="2013-06-26" version="1">MAMRRTVVFAAHTLTIPVPKNRRPKFDLHLRILDLNNVPLVSGTSFIKWHLAHSTAAEHRGRTSSCPVKDHKVAYDYEATLPVRLTVDKSGMLQECYIEFEVVQEYGTAKGERITLGTIRLNLAEYVEQSEMGTAAGEEPGVTRRYLMQDSKVNSTLKIGIYMRQVEGDKNFIAPALKTAQVFSGIAGIMAGDQAELEDQGATHSLTNKSREAGELQDMYRRTLAAYWSAQPGELKADECIEDIFAGGDGWGDRDKASSHARPQVLRFAGGDSSGSVSENESRHMHSSSISRKSHETLRPGDMKPARSQNVRGRESLEQRASHMKAEAARQRQRPNQEVDEFDLREDLVSWHRPT</sequence>
</entry>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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            <dbReference type="PubMed" id="23236275"/>
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    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">28A</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
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    <dbReference type="STRING" id="671987.R0IZL9"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA89991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35433" checksum="5CB502ADE536C455" modified="2013-06-26" version="1">MSARVFLGDEGARNEAWLKITREYTTNGYIASAILRLWPKPLRPLVNRIFPKCRQLRAQVLEARKIVNEIIDRRRKTKADALRQGIPAPVFNNAVEWWEQDTKDESVEYDPVIGQLVLSQSSIHTTTDFLTQVILDIAANPEVKGPLLEEIKQAKSTYGWSKSALYSMRLTESVMKESQRMKPIARCTMNRMVLDDMYLSDGTLLKKGALLGVSVDRMWDERVYENAQKWDGWRFYRKYQQSPDARDVPIVNTGPNYLAWGYGKLACAGHFFVTQEAKIVSSPSDTKVSAFGLVLASNLKARIKIRRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3E9</accession>
    <name>R0J3E9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylanase</fullName>
            <ecNumber evidence="7">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_86616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020477.1">
        <property type="nucleotide sequence ID" value="XM_008022286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3E9"/>
    <dbReference type="STRING" id="671987.R0J3E9"/>
    <dbReference type="GeneID" id="19405599"/>
    <dbReference type="eggNOG" id="ENOG502QSCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_2_1_1"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353354" description="Beta-xylanase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="10">
        <location>
            <begin position="131"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA91261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="414" mass="43827" checksum="5B7C64C6F45350BF" modified="2013-06-26" version="1">MYFTKSTLVAVIGLSSTSAVLASVPPYGQCGGRYYKGENSCTEGWTCVKSNDWYSQCINPTIGTASVLTPVYGAATPVALPLLLELLSLRTAMSPGKEGKGASTTLQTRANGAQCDIDALFKKKGKKYVGTITDPGLLNKAADKAAIIANFGAVTPENSMKWDATEPSEGRFTFGGADAVVNFASSNGKLVRGHTTVWHSQLPAWVSQINDKAKLEAVMVNHIKKVIGHYAGKVYAWDVVNEILNEQGGLRSSVFYNVLGEGFVATAFKAAREADPKAKLYINDYNLDTPNYPKTKGMISNVKKWIAAGVPIDGIGSQTHLSGVWSVSQVPAALEALCGAASECAMTEVDVKGGSAADYKTVFSACLNAKNCVGITVWGTSDADSWLGASASALLFDGSYQPKPAYNEICKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0J453</accession>
    <name>R0J453_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_86875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020491.1">
        <property type="nucleotide sequence ID" value="XM_008022300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J453"/>
    <dbReference type="STRING" id="671987.R0J453"/>
    <dbReference type="GeneID" id="19405613"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002763_0_0_1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="153" mass="16878" checksum="7EB0C42F49094157" modified="2013-06-26" version="1">MHLPMLIGTLALSASMAFAAQAKVHNNCGFPVWVNSVQGKAGLVQKVASGYTFSEEQKPTDNGIGVSVQITMYEDGRSNNDPILIMGYSWDKHAGLYYSLSTVKGFDFWGRKLRIHNTEGKPLEEIVWMGEPEPDYTAAYLNGEADITLELCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>R0J6C7</accession>
    <name>R0J6C7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_30712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020253.1">
        <property type="nucleotide sequence ID" value="XM_008022062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J6C7"/>
    <dbReference type="GeneID" id="19403461"/>
    <dbReference type="HOGENOM" id="CLU_1856534_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA92246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="138" mass="15782" checksum="0677277688AFE569" modified="2013-06-26" version="1">MQSNNSRQNLPINSMLFYDKRESPCPSAFIYRLREPSLVSLRASLDPSLTALPRFSAIILTTTPTVVEENEEEEELVAVKESRRKKFSARIRRLLCLGCKPEHKKERQMKEREEVRLWQPAQPGISTTCSAGTPNFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0JS19</accession>
    <name>R0JS19_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_32924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028085.1">
        <property type="nucleotide sequence ID" value="XM_008029894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JS19"/>
    <dbReference type="GeneID" id="19403713"/>
    <dbReference type="HOGENOM" id="CLU_781120_0_0_1"/>
    <dbReference type="OrthoDB" id="3670965at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="430" mass="48708" checksum="90DC39AD3A9E2C6A" modified="2013-06-26" version="1">MVPFSADVSLVCGLPLSFESKFQRIRTELTFWPGSLKDQPSQEDIVICPDLGGKYQCRICSKYFPCHEPYQHHVTKHGEAIKHIYTKSRQLNPTKSDIRAYHGVYCHRGIHYVRVTISEFFGSTSSIRKIDEEDVLTFGDFHEKKFNSTEIYNYTLERMEEFDSRCCRRIPNTTVVRTLRRLSSHAKTNPIQFSPKNILKLLRSCFACIPTPRWLRPRHWPSIPDPRATSLYPSTEATTTNNAHLLVTDDLISIESQPVSWKSLGHRQDSARPAYSYPSSPTVPQTALVEATPTYAATGQLRISPPFQATNFLPESVTGIVAVGSFCSTSNGVRGHKVLVATWSDTVMLLQQVDLDALLSHERLMNQLQDIVGEQAFGELLKFQDKCMDILEPVYRGILPDDLPIRVGEELSLEKCSPMLLAHVNNCIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUC5</accession>
    <name>R0JUC5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_91311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027210.1">
        <property type="nucleotide sequence ID" value="XM_008029019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JUC5"/>
    <dbReference type="GeneID" id="19405892"/>
    <dbReference type="eggNOG" id="ENOG502QUFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_571205_0_0_1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="238"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="479" mass="54070" checksum="EA107CDE8C677208" modified="2013-06-26" version="1" fragment="single">LASGNYSDLTITCGNDIHKVHKMIVCNQSDFLAAAMRFGGTEAEQATIDLPDDDPETVKLVIEYLYTGHYTSDAQEQPDDSSLDSTSKSRPARKYSRHRYLRECGENCAWDCDIFVCKHCTYVCFGQKPENLLVHAKMYEIADKYQLAGLKALARKLFASEILASWDHELFPAAAHYAFSTTVEEDKDLRDIIIRTIAEHTGLIRTTEIQALMTEFGGLAVGVLLAKADESLASGQYSDLKITCGPDSYNVHKVIVCERAEFFARAIKFGGRESNNSTIDLPKDEPAIIKLLIQYLYEGEYDHSLPNGLKSKQSIINMIPFPHTCSQDDQAQIFGQSWCVDHQCITYCCRKCGNFICPECHSHIKETARFHDPAEQLVTHTKMYEIADKYNVVGLKDLVIEKFSRACEQFWYDTYFAIAAHRAYSTTPDNDRGLRDIVCKTIAQNMGALIKKPSVEALLTEFKGLARDLLKLKIDEGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUD3</accession>
    <name>R0JUD3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_35983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031269.1">
        <property type="nucleotide sequence ID" value="XM_008033078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JUD3"/>
    <dbReference type="STRING" id="671987.R0JUD3"/>
    <dbReference type="GeneID" id="19404075"/>
    <dbReference type="eggNOG" id="ENOG502SMAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054243_5_1_1"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="143" mass="15962" checksum="EA125D7188300BE2" modified="2013-06-26" version="1">MNANSLVLAPEGDVILVVGGKRFRIHADSLFLKRHSTVFAALLGPNFREGQDLNTSSRKKIPLPNDDPYAMTAICATIYHNFSHIPRNPTTDQVLSIIRHADKYDCYDVLTLPSQVYGWLKSDHLTLGKDPANILAVSYLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUR6</accession>
    <name>R0JUR6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beige protein homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_42006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in protein sorting and cell wall formation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027080.1">
        <property type="nucleotide sequence ID" value="XM_008028889.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0JUR6"/>
    <dbReference type="GeneID" id="19404739"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000175_2_0_1"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="8">
        <location>
            <begin position="1829"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="7">
        <location>
            <begin position="2002"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="2427"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="965"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1156"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1733"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1775"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2282"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1734"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1776"/>
            <end position="1790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00054699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA84773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="2627" mass="294940" checksum="9B25EBAD1C188F9F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JVG8</accession>
    <name>R0JVG8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_99249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <property type="match status" value="1"/>
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    </feature>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA82119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="738" mass="83266" checksum="74BA27CD5E8ACBE1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYF3</accession>
    <name>R0JYF3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gcp-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_98376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030777.1">
        <property type="nucleotide sequence ID" value="XM_008032586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYF3"/>
    <dbReference type="STRING" id="671987.R0JYF3"/>
    <dbReference type="GeneID" id="19406367"/>
    <dbReference type="eggNOG" id="KOG2707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_4_0_1"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="2">
        <location>
            <begin position="66"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Gcp-like" evidence="2">
        <location>
            <begin position="199"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Gcp-like" evidence="2">
        <location>
            <begin position="319"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA81262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="504" mass="55462" checksum="6C2930B223E2DD24" modified="2013-06-26" version="1">MRPRSLLLQATIRFRTTRPLQWRLQRCLMTLAVETSCDDTSVAIVEKGRQHGRTTAQLHFHKKVTSNNTQYQGVHPLVSLQSHQESLATLIQEAIRHLPLRNGQLLPKAETMQPGEVDLATRRLPDFISVTRGPGMRSNLFTGLDTAKGLAVAWQKPLVGVHHMQAHALTPRMVSALESDTNPLPEGKSLSASTDADVTPEFPFLSVLASGGHTLLIHSASLTDHRVLGTTHDIAIGECLDKIARVVLPAESLQTTKSTMYGALLEAFAFPNKEATGPVDTQPSAPISKQSINSAESYLNGYGRQYDWYKVPANQEDAIRRNATKWGWALNKPLTKAGGGIKINSLEMSFSGITTMVERIVRFGMDPATRKFNKVERASADIETEERRDLARETMRVTFEHVASRVVLGLQSQHEAMTVKPAVVLAGGVAANSLFRHILASTLCAHGFSDAQLYFPPPKYCTDNAAMIGWAGLEMFEAGHVDPFSIRAVRKWPLDKLLDPPEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYQ1</accession>
    <name>R0JYQ1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_22573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029353.1">
        <property type="nucleotide sequence ID" value="XM_008031162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYQ1"/>
    <dbReference type="GeneID" id="19402573"/>
    <dbReference type="eggNOG" id="ENOG502RB0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1758506_0_0_1"/>
    <dbReference type="OrthoDB" id="3679518at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="146" mass="16491" checksum="0BD891FEA87C0850" modified="2013-06-26" version="1">MERKDWQESHSQARHSMSHVAEDHSQKLASIRQRADSHQPRTCTSTSPRPRQPSEVDHLAPQAVISAYLRSSYNGDDADRPRRFSSAAEAYDAPSSSHHKPPGEMRQISGNFNAPTKIEVERQRSHRKRSRGMGKLKDAVKALVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYX4</accession>
    <name>R0JYX4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_151589</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026353.1">
        <property type="nucleotide sequence ID" value="XM_008028162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYX4"/>
    <dbReference type="STRING" id="671987.R0JYX4"/>
    <dbReference type="GeneID" id="19397127"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="400"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="464"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA86083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="740" mass="84850" checksum="58845C547E2667E4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZ14</accession>
    <name>R0JZ14_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_22662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029372.1">
        <property type="nucleotide sequence ID" value="XM_008031181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZ14"/>
    <dbReference type="STRING" id="671987.R0JZ14"/>
    <dbReference type="GeneID" id="19402592"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660837_0_0_1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="8">
        <location>
            <begin position="214"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="386"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA82689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="416" mass="44966" checksum="34A16719481C0F8B" modified="2013-06-26" version="1">MKHDHAGKSLFEDANAWVALTEIFANVLQDASLGTTYLIIDALDECATDLPKLLSFIAKHSSASSRVKWIVSSRNWLDIEEELERAEHEMRLSLELNAESVAAAVDVFIRQKAYASALLFSPADSIVRRLFQHEEPRGVTIKPAMSNGWSACLQTLEGHSSYVSSVAFSHDSTRLVSASYDKTVKIWDASSGACVQALEGHSSYVSSVAFPHDSTRLASALYDKTVKIWDASSGTCMYTLEGHSSYVRSVAFSHDSTRLASALDDSTIKIWDASSGTCVYTLEGYSGDVSSDASSGTCVNTLEGHSSYITSVAFSHDSTRLASGSLDSTVKIWDASSRTCVYTLEGHSSYITSVAFSHNSTQLASASDDKTVKIWDASSGTCVYTLKSHSGDVSSVAFSHDSTRLVSASRDKTVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZC6</accession>
    <name>R0JZC6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_165211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029818.1">
        <property type="nucleotide sequence ID" value="XM_008031627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZC6"/>
    <dbReference type="GeneID" id="19399386"/>
    <dbReference type="eggNOG" id="ENOG502S9QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078299_1_0_1"/>
    <dbReference type="OrthoDB" id="2274804at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="9">
        <location>
            <begin position="43"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="262" mass="28293" checksum="810D81B2C0CFE241" modified="2013-06-26" version="1">MATRGGDVDMADAPVEARDADDHASVLQTNYSDAFAFSDSERLALQLYDQLYELELQQSLVGAQQSAQAHDFSALPDDLVEERLTMAQREAMEARAAYEMRNRITHKVLVMDPVLQAVHGGGGGGGGERTAAFAAKRILPLMAENDTVSMMHGAQTAKLASTMRALSAAEQANMVANRQNRELAQTMVALAEEMKAQSAQDIQDPQLRAQVDAVDQQLRASRRRAKTLQGVLAGMIVGSGINWAADEGLSELVMEGEGEEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZR1</accession>
    <name>R0JZR1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">40S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_98745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031057.1">
        <property type="nucleotide sequence ID" value="XM_008032866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZR1"/>
    <dbReference type="STRING" id="671987.R0JZR1"/>
    <dbReference type="GeneID" id="19406389"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_0_0_1"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
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        <location>
            <begin position="4"/>
            <end position="104"/>
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    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="105"/>
            <end position="178"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA81657.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22137" checksum="0ED6AFEA3A9CE0F2" modified="2013-06-26" version="1">MAPRSYSKTYSVPRRPFESARLDTELKLVGEYGLRNKREVWRVQLTLSKIRRAARSLLTLDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKIEDFLERRLQTCVYKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFMVRLDSQKHIDFALTSPFGGGRPGRVRRKKAKAAEKGGDDDAGEEDEE</sequence>
</entry>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_60404</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14485" checksum="76EB4A5AFFC365BC" modified="2013-06-26" version="1" fragment="single">MAPGERSEEVWLWYTAGHQLRAHCAAGGKAQVGVCLKHLPSPWAGSNNNNSNNKNREARFHSGNVPWQRVINAKGAISPRGPGAAGRQAEALRREGVVVELRQHGLGVYSVDLGEYGWFPDMLPSEAGGIDESD</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_79704</name>
    </gene>
    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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    <dbReference type="HOGENOM" id="CLU_1267474_0_0_1"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="198" mass="23255" checksum="F6997A9E23F67723" modified="2013-06-26" version="1" fragment="single">HHTPPTTPPARKIGLTWDDFQYEDDTEALHESPPARAKPPTALDLTISKLHHDRQRFTKTIPNDHKNKLCSPRDRSAVLDIYTEALHKINATNHAQMYTEANAKIRTVLGIHKAGTRDAVFTHQLLRPIEPLYAMPRIEVRHDKHGHRAAVRIQEWRRDGWPAKYPVNAVREEKARKGRFVRWFEEEWEDEVEEEWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0K104</accession>
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        <recommendedName>
            <fullName evidence="1">TIM-barrel domain-containing protein</fullName>
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    </protein>
    <gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029100.1">
        <property type="nucleotide sequence ID" value="XM_008030909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K104"/>
    <dbReference type="STRING" id="671987.R0K104"/>
    <dbReference type="GeneID" id="19401226"/>
    <dbReference type="eggNOG" id="ENOG502QQGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058589_0_0_1"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="10"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="279" mass="29521" checksum="36F620B808D3850D" modified="2013-06-26" version="1">MSPPTDRSSILQNLRSQINNGKIIVGAGAGIGLSAKFIEAGGGDLIIIYNSGRYRMAGRGSLAGLMPYGNANDVVLEMAGEVLPIVKSTPVLAGVCATDPFKDMSRFLKQLKDLGFAGIQNFPTVGLIDGTFRQNLEETGMSYDAEVEVVKMAREMDLLTTPYVFNVDEAKKMASAGADILVAHMGLTTSGSIGATSGKSLDDSVKLIQEIRDAASDIKSDIIILCHGGPIAKPEDAEYAISRTKGVHGFYGASSMERLPVEDAITNITKTFKGIKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1P7</accession>
    <name>R0K1P7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lysine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_164886</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029246.1">
        <property type="nucleotide sequence ID" value="XM_008031055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1P7"/>
    <dbReference type="STRING" id="671987.R0K1P7"/>
    <dbReference type="GeneID" id="19399279"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000044">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="250"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA83569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="601" mass="69065" checksum="0CBB0C3155BBD4EB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1V6</accession>
    <name>R0K1V6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_173223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20153" checksum="2846DFB676084E20" modified="2013-06-26" version="1">MGGYLSTFTKLIWAKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESVTYKNLNFNVWDLGGQTSIRPYWRCYYANTAAVIFVIDSTDIERLTTASEELRAMLNEEELRDAALLVFANKQDQPGAKGAGEISEALRLGELKDRNWSIVACSAVDGRGVQEGMDWLVSNVGEGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2L6</accession>
    <name>R0K2L6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_31652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025084.1">
        <property type="nucleotide sequence ID" value="XM_008026893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2L6"/>
    <dbReference type="STRING" id="671987.R0K2L6"/>
    <dbReference type="GeneID" id="19403567"/>
    <dbReference type="HOGENOM" id="CLU_894713_0_0_1"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343778" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40416" checksum="133282FDB5B677F7" modified="2013-06-26" version="1">MKSILALPAILGAVSAAAVPRAQSPCVSNGRSTAPEPAVNTLAGFNESANYSMLARNAVKPEGYELIMSDTKCALSSSKYMRYSRMSSYDSQTCAKMCDSHPGCDTFNIYVERYPSVVPDESCPNPSAIFFAICALYSEPITSAACDNPGQFIGPQDASGNPFRTAIRASNAYRRLRVKEVIVTVTTTRNILTDPERLKVYVHTGSAKHHANATTSSVAKVTPSIPIKDTAPMMAMHGPLRIYTVTEAEITSRQSLDDTVPMMAIHGPLQISTLEPKITPCPTVDDTAAMMGKHGPLHISTVTEDDTEDDIDEGSSAWVSSFYSMMRELHPEVSIRPVSSTRGWNGRLWMRNAHTEPTPMPRQLSETITYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0K2N1</accession>
    <name>R0K2N1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division control protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_163349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025813.1">
        <property type="nucleotide sequence ID" value="XM_008027622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K2N1"/>
    <dbReference type="STRING" id="671987.R0K2N1"/>
    <dbReference type="GeneID" id="19398741"/>
    <dbReference type="eggNOG" id="ENOG502S6JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052857_0_0_1"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32820" checksum="C814F75BAEE6FDF2" modified="2013-06-26" version="1">MEALLSLAFDNIASKDTQKIRKGLRQIEGMLAQICLSSGKSKPCTPAHRRNASAISLGEQQQQQQQQQQATPKKLGQLSDDLAFREFFRLQEGFEWNVVTRVADCLDRLLGMGSSKDGQNDILILSSLSNMQGLLLLHPPSRIIFGREVYMNLLLDLLDPYNCPAIQSQALLVLVSALLATPQNTRIFEHMDGLLTVTSLFKDEETTQGVKVKLLEFLYFYLMPEVPVSGAQRNRTKVAAAMDRRNSADEGAEGIRRHTRSQAEKQHMLGKYLNNVDALVQDLQESAPFTNVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3E9</accession>
    <name>R0K3E9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">NCA2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_156570</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029894.1">
        <property type="nucleotide sequence ID" value="XM_008031703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K3E9"/>
    <dbReference type="STRING" id="671987.R0K3E9"/>
    <dbReference type="GeneID" id="19397639"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008227_0_0_1"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA82907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="90690" checksum="80ED536A6D939C2F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0K423</accession>
    <name>R0K423_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_108979</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024699.1">
        <property type="nucleotide sequence ID" value="XM_008026508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K423"/>
    <dbReference type="STRING" id="671987.R0K423"/>
    <dbReference type="GeneID" id="19395332"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015739_0_0_1"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353912" description="Amine oxidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="12">
        <location>
            <begin position="251"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="331"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA87843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="784" mass="88048" checksum="E2734476EE5C51B8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4X7</accession>
    <name>R0K4X7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_90987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="HOGENOM" id="CLU_062261_0_0_1"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="283" mass="30730" checksum="093244EECD170A43" modified="2013-06-26" version="1">MVSEANSSTHQRLANTIASLATVGANFEDIHIAIQSTLSRLVTPMVDDSILGSNHPVTAALRLLLGSGVAKVVRLQLVQVWFAPLVAQNLKSQYGDRILFLDAEGVAQNARSVQKPWNGVYVGTHMTALGLDIEAVVDALSPSHGSPSSMPSSISSSVGSAFSSLDTFSVTEFELGCEDAKNEESKDESANDDSFFSGINIEEWDASTQVTEQHDLLGSEEMEVDDDVSDDEELEDVSQEDFDAIMGNMEDMANYEANQCDMTYMTNFAPELLLSRYHLGHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5Z0</accession>
    <name>R0K5Z0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_20444</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026893.1">
        <property type="nucleotide sequence ID" value="XM_008028702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K5Z0"/>
    <dbReference type="STRING" id="671987.R0K5Z0"/>
    <dbReference type="GeneID" id="19402320"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_9_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="246"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA84929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="345" mass="37515" checksum="FDD8359DB6761AC7" modified="2013-06-26" version="1">MSKPSEKPQPQAAAIMSDEPGEGVKALGTPDITSLQRIRQVFAQPVLASFVAGGVAGAVSRTVVSPLERLKIIFQVQSVGREEYKMSVPKALAKMWREEGWRGFMAGNGTNCIRIVPYSAVQFSAYNVYKRFFESEPGASLDAYQRLFCGGLAGITSVTFTYPLDIVRTRLSIQSASFSALKKEAGQKLPGMWALMVDMYKTEGGISALYRGILPTVAGVAPYVGLNFMVYEIARTQFTPEGEKDPSAVGKLAAGAVSGAVAQTITYPFDVLRRRFQVNTMSGMGYQYTGVGDAVKQIIKTEGLRGMYKGIVPNLLKVAPSMASSWLSFEMTRDLLMGKWNSGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0K610</accession>
    <name>R0K610_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1774-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_21105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027982.1">
        <property type="nucleotide sequence ID" value="XM_008029791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K610"/>
    <dbReference type="STRING" id="671987.R0K610"/>
    <dbReference type="GeneID" id="19402400"/>
    <dbReference type="eggNOG" id="ENOG502REZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061220_0_0_1"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31680" checksum="75F88E34AE5CB3B1" modified="2013-06-26" version="1">MNPFAKRDEHSSQAILLYKITTSLSYVLLVVTTFYYTFHAPKGHGNHRFWHNNPPTPFAQSSLFTSIYWLILFTAQLLYAYALYTSDAVYVTSAANIGSHFIANNLLLFGFVNLFVRSHFWLAEVLLVINFFNLSFAYFRHSTSPRTIHIGTVSGPLAWNFVALYWVGAVAVHTNHEAARILANIFIWGWLAYGMFFLVAYKDYTMGFALSLLSFSTGVGQFLTRPHILQLQWIFAFSIGGLLFVLSLAVAMPGLLGRDPFPRGQIVSEERERAPLLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6C3</accession>
    <name>R0K6C3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_129468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023943.1">
        <property type="nucleotide sequence ID" value="XM_008025752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6C3"/>
    <dbReference type="STRING" id="671987.R0K6C3"/>
    <dbReference type="GeneID" id="19396080"/>
    <dbReference type="eggNOG" id="KOG2904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_0_0_1"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="392" mass="43523" checksum="0A5360AE379F722F" modified="2013-06-26" version="1">MPRIPTSLIRKARAIDAFLPALLAPCRDLQAAQNELRWLREHVDKVAKRDRLAKGALLRQLVRERASGKPLQYILGTEYFGDLEIQCKPGVLIPRPDTAASVTHLVNLLRRSQNLPSELHLLDLCTGTGCIPLLFQHELLSARKDIDLRLLGVDISKKALDLAQSNLQRLVKSQPFGKRAQTSFVQADVLIDPSADQSGKILPLRAALNYALQPAQWDILISNPPYVSPSAFWKTTTRSVRAFEPKLALVPPSRAKYTDTQQGDMFYPHLLQIARDVEAKVVLLEVADMEQALRVASTARHLHLFDGIEIWKEDPTAASTVMTKDEFDIIGEGNARSVVCWRGRGTSWLGKSATDTATPTAEADSLSWNSPKVDTHHLEPQFIKSVASGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6R2</accession>
    <name>R0K6R2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_21334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028004.1">
        <property type="nucleotide sequence ID" value="XM_008029813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6R2"/>
    <dbReference type="GeneID" id="19402422"/>
    <dbReference type="eggNOG" id="ENOG502SJWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026304_1_0_1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="535" mass="60573" checksum="A6001AD89EF56302" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6W2</accession>
    <name>R0K6W2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_20797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="248" mass="26240" checksum="397114C04476C77A" modified="2013-06-26" version="1">MLFTAPLSLILALAPSALLAAPTQHMDSIAALIPRQNLPAGVWEQLRKTDSLCDLSNVKLPIAPTPLGSPAEGLSLRHIAIGRGTQNYTCASASAMEVPKATGAIASLFNATCDAARLNTDVLAQVTTLALNYAIPTSPEADNRLSGHHQFTAAGVPLFNLQTENADYGRVECAVNAKSPAPKAAALGKNELGSVPWLKLNATVGDDKQWAYKEVYRVHTAGGSAPKTCEGIEGSFTVEYSAEYWFYA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
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            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="314" mass="35710" checksum="86A48CD4E7E107EC" modified="2013-06-26" version="1">MLSRSLHLSKVLNYHSLIALCTIGAIYHFLSIRSQFTVRAPFAHTDAQQSEIPKLIWYKLGPNGLSEDARNWTNSCIQNNPTYEARFITDESGDEYVRKAFAFRSDIVDSYLALPVPIYKADFLRYLLLWDQGGIWSDLDVSCKTPIDEWVPPEYQKDAAVVVGWEFDHGWPGQYIRQFASWTMMAKPRSPHFMQVIDDILEKLQEQMAKHHLPSIANATLDIMGDVVDFTGPRRLTRGIIRSLEKQLNQSIDAIGDLKELLQPKLVGDVLVMPGRSFAASSNTYTPEQEALLPKQLVEHHYAGSWKNSKGGEQ</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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            <end position="42"/>
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        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <sequence length="380" mass="40787" checksum="A4D892C1F1671705" modified="2013-06-26" version="1">MSHMSVGVTSKGKDRKEYKLQRPSRSSSSSSSDSGHGKSGLIGTAIGAGLAAAALGATSSKKRHGRSRSPKKVQVLHNRRESNDEERMRRSQELRRMASRTSSSGASVIEIGQHHQYEGGFFQGFFAAPPPKEKPVKSPSLKKKKKGFFNFANASTSSSDSEMAFGTGYVRRRRRSSHTRRQSPSRRQSPSRRQSPSRPPVSSRPPSTRRRDSDERLKASLIGLGATAAAITAAKAGKRKQSRETLVTKENRHSRKTSQASGQGSLYGDDEWEDLPDDGASQVSSDGGLAYGDYGLKKSKSNDSLGSNDSGTNKWGWRWGFSKKKRRPSNNLYDNIAETSLIGPAAAGAAGAAGAAAGTAVGSAHRRHDSEAVTVALAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9U1</accession>
    <name>R0K9U1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_26080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022410.1">
        <property type="nucleotide sequence ID" value="XM_008024219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9U1"/>
    <dbReference type="STRING" id="671987.R0K9U1"/>
    <dbReference type="GeneID" id="19402975"/>
    <dbReference type="eggNOG" id="ENOG502S81D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088319_0_0_1"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="195" mass="21095" checksum="2954118D0C83A7AE" modified="2013-06-26" version="1">MADHTFHPRDALANTLSTTLQTTAVGAVVAGVRNTLRKQNVGAMGILTRSGGIIALYAGVGATYQFTLDATSNLRRSDDCYSEAVAGFAAGCAVGVARRSLPFMLGAGACFSTALTAYRYTMGLRGVGDIREQVDDDGEVERREELKKLRRRPLSETLQQLGEGRGIYGPGYEERRRQRLLEKYGIDVKAAQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAC3</accession>
    <name>R0KAC3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_104871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022813.1">
        <property type="nucleotide sequence ID" value="XM_008024622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAC3"/>
    <dbReference type="GeneID" id="19395067"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA89928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52209" checksum="7A493FCEE6A6496B" modified="2013-06-26" version="1">MFNSWGLVNAYGTWSSYYVGHSLRGIDQLQLNLVGSTESALVLLLSNVVGRLLDAGHFRKVIGCGTFLVPFGLFMLTVVHPNDVEALANFGSIWVTQGFVVGLGMATFFVSSSQVASTWFPKRRGLAVGYVACGASVAGTIYPTMLRYLIQSVGFNNAVRYVATLTSVTCIYSFIFCTTDPAHEHHTPKTWGSIGTWVDGEAFRNKAWCWFTAGIAFMFFGFYPVFFNLEEWASVRGYGTRDRTGSPVSPSDTTNKPLQTFWLLVIMNGASTVGRMLLAHFSDRIGAVNMHIGSQFTASLLTLILWTLAGSETDAIAFCIVFGIFSGMVIGLPPASIGNILNCSYTAPGTTHFAKKKLGHWTGMMYTFAAIPALTGPIIAGHLITSYETYITVQMWSGTNLLISCLCMCVSRWYLPCANGDHAKDALKRSSIFSKVYASDKRNSTGPDTFSQAPTRVPSTAPSRPVSQDSLYDVQGRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBZ8</accession>
    <name>R0KBZ8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_102512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022303.1">
        <property type="nucleotide sequence ID" value="XM_008024112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBZ8"/>
    <dbReference type="STRING" id="671987.R0KBZ8"/>
    <dbReference type="GeneID" id="19394927"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107649_6_2_1"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF116">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="6882" checksum="E35AD13CC568962E" modified="2013-06-26" version="1">MLTPSSDICKILLAIILPPLGVFLERGCGADFLINILLTILGYIPGIIHALYIIFKSARLPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCQ7</accession>
    <name>R0KCQ7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_19645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024935.1">
        <property type="nucleotide sequence ID" value="XM_008026744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCQ7"/>
    <dbReference type="GeneID" id="19402222"/>
    <dbReference type="HOGENOM" id="CLU_811734_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="342" mass="37600" checksum="466E220AE2303BC5" modified="2013-06-26" version="1">MPRSEKASKVSQLVDFYQNTATPSAPIPKKPTRKTLAIEPGPSPEADLVKDTPNLQELPKASIYDFDGDSTAVPSSVSSPQTPVRMRSTSSSASRDNTISLPITVTLPTEADRKDYRVEVIGFTRVSVYSDDAPAEGFGSIISHPYTPFCMEQTSRTLSRSTSAQTSSGLTPDENRHLLNKMTSERQLVRPAPEEQMNHTIHSAYGLVCPVGWRSFKGDNSDTQCSHSMCSHAMSEARHESLAQDHIPAFTQIIMAQRNLQRYAKVSQSAQSVVDDVIGPDWVLGDEGQKTPVTRSMTCQDIPRDRRNSLDTLQSVGLKDKLRRVGRKFRGSGTNGKSTSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCT4</accession>
    <name>R0KCT4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Dicer-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_45051</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021336.1">
        <property type="nucleotide sequence ID" value="XM_008023145.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0KCT4"/>
    <dbReference type="GeneID" id="19404969"/>
    <dbReference type="eggNOG" id="KOG0701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_4_6_1"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001669">
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    </dbReference>
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    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="31"/>
            <end position="210"/>
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    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="382"/>
            <end position="558"/>
        </location>
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    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="19">
        <location>
            <begin position="576"/>
            <end position="669"/>
        </location>
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    <feature type="domain" description="RNase III" evidence="16">
        <location>
            <begin position="938"/>
            <end position="1078"/>
        </location>
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    <feature type="domain" description="RNase III" evidence="16">
        <location>
            <begin position="1118"/>
            <end position="1294"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001936"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EOA90708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1430" mass="160943" checksum="8753C68DDFF00B1F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KD41</accession>
    <name>R0KD41_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_163275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008027553.1"/>
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    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="112"/>
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            <end position="154"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA87299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29687" checksum="255630F5B8C63167" modified="2013-06-26" version="1">MSVKFDKETFHSAADAASHHKDDLMHEIGQAITQGGGPNGYLAAYLRQLQSNPLRTKMLTSGTLSGLQEFLASWIAHDRSKSGHYFTSRVPKMAIYGAFISAPLGHVLITALQKLFQGRKSLKAKVLQILASNLLVAPIQNSVYLISMALIAGARTFHQVRATVKAGFWPVMKVSWVVSPISLAFAQQFLPETTWVPFFNIVGFIIGTYINTHTKKKRLAALRRKHYGEGGGRPASRPGSRPGSRPGSRPGSISGRTVDEYGRPDDRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDB0</accession>
    <name>R0KDB0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_136143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Dhillon B."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="PANTHER" id="PTHR10485">
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    <dbReference type="Pfam" id="PF02466">
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="106"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    </feature>
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        </location>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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    <dbReference type="AlphaFoldDB" id="R0KGS5"/>
    <dbReference type="STRING" id="671987.R0KGS5"/>
    <dbReference type="GeneID" id="19402240"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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                <person name="Condon B.J."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
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                <person name="Hamelin R.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908559">
        <property type="protein sequence ID" value="EOA88007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024502.1">
        <property type="nucleotide sequence ID" value="XM_008026311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJ07"/>
    <dbReference type="STRING" id="671987.R0KJ07"/>
    <dbReference type="GeneID" id="19396109"/>
    <dbReference type="eggNOG" id="KOG4824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122461_0_0_1"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="39"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="193" mass="20904" checksum="E0AF516A30461FF6" modified="2013-06-26" version="1">MLFPRADASTNDTTPSSPNVVAAHYDGSCFYPVPDPTFNLNKYLGTWYQVAGTPFGPTAGARCVTANYKLNDNGTVRVLNSAAAGPSTFSITGTATPVDPAYGLAGAFKVEFPNTLSQDGDCRGPNYIVQDYAVDWAIVQTQKWNTLYILSRVRQPSEEGIQAWIDRAVAFGSNREAIIRFNQTGCEGMNAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKQ1</accession>
    <name>R0KKQ1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_37362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022464.1">
        <property type="nucleotide sequence ID" value="XM_008024273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKQ1"/>
    <dbReference type="GeneID" id="19404247"/>
    <dbReference type="HOGENOM" id="CLU_700171_0_0_1"/>
    <dbReference type="OrthoDB" id="3478523at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50750" checksum="431B276845E0F47E" modified="2013-06-26" version="1">MTSKIANSKFRRISLNLEKLPCELHEPVLADLEFHQLIRLSAHAGPRLAWSLQNSLAPWSPCFRQQGDMGEWQRLLSVSDSIRKFCFAQPKTKDHVPWVFEHGDLAFLVYKKAQWARGGTTSLVPEHTLRNGKALARHWLAALNHIVVDATWSTLHDDYARTVEPWASSVAGAKDVFSKIPDIGIMTTTTRSNEPSTTLRSKYKPRASKVVNAKTVFTSRELVRFVDLYQQVRVKRAEAFAQELYRLAHLYDAHAARLKMPFDPRLHAPDDLNAAHIPTTMRCQARRLVRLAQCTRWRRSDAFKHRFAWPALIPYDWGIQLFNTVVQKPGFLDQDGAEEGPAEREAATVALVKQCRYIVASPPCWATGGPKTHTNAVARLSSKMGRQHLGEQAPDTSIPLCIRVDKTDIGWRELGKLHVVPRGEAELQWLQTFAEVTASMEQGYPNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0KM84</accession>
    <name>R0KM84_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_148733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023649.1">
        <property type="nucleotide sequence ID" value="XM_008025458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KM84"/>
    <dbReference type="GeneID" id="19396989"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001695_1_0_1"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="894"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA89042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1175" mass="130195" checksum="C3E7D1EE87FF5A3C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNP8</accession>
    <name>R0KNP8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_104172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022528.1">
        <property type="nucleotide sequence ID" value="XM_008024337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNP8"/>
    <dbReference type="STRING" id="671987.R0KNP8"/>
    <dbReference type="GeneID" id="19395029"/>
    <dbReference type="eggNOG" id="ENOG502SBU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181714_1_0_1"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA89532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="84" mass="9128" checksum="2A126DFE4D597896" modified="2013-06-26" version="1">MEDAPASPSQPAKSTCKSGNQAQEDFGALYLRKIASEFADDLDKVREAQDFKASSVPMLIHALKQGESLFTAEEKRRVVAATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPV5</accession>
    <name>R0KPV5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_125506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021715.1">
        <property type="nucleotide sequence ID" value="XM_008023524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPV5"/>
    <dbReference type="STRING" id="671987.R0KPV5"/>
    <dbReference type="GeneID" id="19395972"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_13_0_1"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28874" checksum="B7668C433FC90B60" modified="2013-06-26" version="1">MPDPRVFIIRHGETEWSLNGRHTGISDIPLTANGEKRVRATGKALVGDDRLIVPSNLAHIYVSPRTRAQRTLELLNLGCKERYPWSSSSSPAECAPDIRTHCKIQVTDAVREWDYGDYEGRVSREIREDRQKRGLGADWDIWRDGCEGGESPEDVTRRLDQFILELREKWHKGRFGKDGKPNDVLIVAHGHILRALAGRWVGKKLEDNPSLILEAGGVGMLSYEHHSIDEPAILLGGAFVVDVVEKEQEEREAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQ76</accession>
    <name>R0KQ76_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_65284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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                <person name="Han J."/>
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                <person name="Horwitz B.A."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
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        <property type="protein sequence ID" value="EOA90762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA90762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="439" mass="49336" checksum="C5919EB04A092B2A" modified="2013-06-26" version="1">MASSKPSYLVVGAGVFGISTAYHLIKKYPDRQITVVDQDAWDAESRVAASWDWNKVVRADYDDLIYCRLALEAQDVFKQDPLWQPYFHETGIFWVCRSDYAQDVIDNYKKLGREADLQAVSVEEAKKMFGGLFDEANYDGAKSVLVNKTSGWAQAGDALRAVTKWSIEQGVKYVTQKVESLEFDSTGRCTGVRTEQGNTLSATHTILSTGAYTAKLLEQAAHKSGNPNLRAGSRIVAGGITTGMTTLDEQSYEKFKHMPVGVQGYTAAYGPFIGSLPPTKDRELKWWGEKIFKNTHEVLPGRFVSAPPSSKDYSQWDVPGPLKLDISHANHVFYGKKGANWKMDKHRICWDAFTTSSDFIISPHAAAKGLYVATCGSFHGYKFFPVLGKYVVQMLEDDLEPELQQKWAWDRERPAPSLNPDWPRFEMTDLLDQWPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSS4</accession>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_45121</name>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19404977"/>
    <dbReference type="eggNOG" id="ENOG502SURK">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133390_0_0_1"/>
    <dbReference type="OrthoDB" id="4155163at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="163" mass="17478" checksum="6BC1803EA1122277" modified="2013-06-26" version="1">MSGSSRADLAAAATSTVLTADQIMKAIEASHEGKEAHAKKHIGYAAIGAAVAVGAMELFRRDELDRQGKDEDDDNVVVLGEHNKCGHHHHDHDSHVLRVDPKCSKDHVPPGHSRRLAEEIIGAYSLGQEIMGNKKHHVAHVVAEAIGAIAAMKDTRDHVSGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0KV13</accession>
    <name>R0KV13_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_18265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020065.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KV13"/>
    <dbReference type="GeneID" id="19401932"/>
    <dbReference type="HOGENOM" id="CLU_1846138_0_0_1"/>
    <dbReference type="OrthoDB" id="4802779at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="133" mass="14658" checksum="6207E99A94DFDE57" modified="2013-06-26" version="1">MFVLFGAVALAGDPPSGNWWSTDCYSSGIYFNDTSTNPPTRVYTHPGDAGFYYDWMLTRHVCEDDFSPSARYLEGIGRCVANEEGYSINGALSWSSCAAHARQGFFGYNDNGDQDYSQKYVGNAEGRGYLPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KV44</accession>
    <name>R0KV44_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_152681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="9">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020749.1">
        <property type="nucleotide sequence ID" value="XM_008022558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KV44"/>
    <dbReference type="STRING" id="671987.R0KV44"/>
    <dbReference type="GeneID" id="19397217"/>
    <dbReference type="eggNOG" id="ENOG502SBQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166246_3_1_1"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA91612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="72" mass="8364" checksum="BE441D47AB26793A" modified="2013-06-26" version="1">MVKAIRGTLVKCDASIKAMLVDIDSKNNNEYIIEELDEEHILVKETKINELKSRLNQMMRERLKEPESSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KVV2</accession>
    <name>R0KVV2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_162452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020915.1">
        <property type="nucleotide sequence ID" value="XM_008022724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KVV2"/>
    <dbReference type="GeneID" id="19398400"/>
    <dbReference type="HOGENOM" id="CLU_1679034_0_0_1"/>
    <dbReference type="OrthoDB" id="3873085at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA91892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18741" checksum="C00F795521D4EE25" modified="2013-06-26" version="1">MSTPRSKEHLRLALEIRRNGLPAPVPCDYCFANNRQCVAMPEVDGKRLKCSECTRLGHPCVNMSWVSLDKTREEYQKKVDKDKQLLAQVISRLMRNKKILKQAKERAAKKTMCLANSLRAGGDDVDAQESLDCPAADALVGFSPVMWSTLGSLDALASPSNSSDAPIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KW01</accession>
    <name>R0KW01_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_114035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020941.1">
        <property type="nucleotide sequence ID" value="XM_008022750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KW01"/>
    <dbReference type="GeneID" id="19395617"/>
    <dbReference type="eggNOG" id="ENOG502QU9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="308" mass="35401" checksum="4512BBF1E4E5BB49" modified="2013-06-26" version="1">MGKKRVLISYGVDVDAVCGWLGSYGGEDSSNDISRGVFAGTVGTQRLLKMFKKYDIKTTWFIPGHSLETFPEDMAAVRDAGHEIGLHGYSHENPTDMTIDQQRDILDKTYRMLTEFAGKPPRGSVAPWWETSREGAELLLSYGIEYDHSMSHHDCQPYYLRTGDQWTKIDYKKTAEEWMKPLVAGQDTGLVEIPANWYLDDLPPHMFIKKAANSHGFVNARDTEDLWRDHFDYFYREYDEFIFPITIHPDVSGRPHLLLMHERLIEHFKKHEGVEFVTMEQMVDEFKKKNAPPKGALLPAAPGLMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0I643</accession>
    <name>R0I643_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_166407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">28A</strain>
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        <source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003827"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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    <evidence type="ECO:0000313" key="11">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    <evidence type="ECO:0000313" key="3">
        <source>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030091.1">
        <property type="nucleotide sequence ID" value="XM_008031900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8T1"/>
    <dbReference type="SMR" id="R0I8T1"/>
    <dbReference type="STRING" id="671987.R0I8T1"/>
    <dbReference type="GeneID" id="19403925"/>
    <dbReference type="eggNOG" id="ENOG502SH4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342222" evidence="3">
        <location>
            <begin position="18"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="237" mass="26250" checksum="E563757050B9926C" modified="2013-06-26" version="1">MKVASFILSLLASGGVAEETLCQNYQSYSSNNYEVINNLWGISSASSGSQCTYVDSVSSTGAKWHSTWEWQGGQNNVKSYVYSALQFTKKPITQYTSMKTEAYWVYNTTNIRCDVAYDLFTSANVNHATTSGDYELMVWLARYSVDPIGTSQGTVTVAGQTWELFAGLNGAMEVYSFVASNTIYNFDASMLDFFTYLPDNMGFPGSSQNLITFEFGTEAFTGGPALFTVNQWDAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0I970</accession>
    <name>R0I970_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_78268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030185.1">
        <property type="nucleotide sequence ID" value="XM_008031994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I970"/>
    <dbReference type="GeneID" id="19405418"/>
    <dbReference type="HOGENOM" id="CLU_2460905_0_0_1"/>
    <dbReference type="OrthoDB" id="4227485at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="89" mass="10718" checksum="E11716B4A30AAE26" modified="2013-06-26" version="1" fragment="single">MIPFLRTFFEDQKYLEPCSKILKQLLGVKSKRPIWKEFKANYWGHESEIKVQISETKNLLLPGPLGKKERAKLGYLQSWMFCFRHWPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9C6</accession>
    <name>R0I9C6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="18">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SETTUDRAFT_165510</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="18"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030332.1">
        <property type="nucleotide sequence ID" value="XM_008032141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9C6"/>
    <dbReference type="STRING" id="671987.R0I9C6"/>
    <dbReference type="GeneID" id="19399496"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_0_1"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="16 23" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
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            <end position="259"/>
        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EOA81981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="452" mass="51484" checksum="1B82FF5735EA904D" modified="2013-06-26" version="1">MLKSVLHVANEPQKSAIWGRAINRGSLGYSVLSASLVCATPLLGITFSIIINDFQGSVLGFVYAAYSGKLSSILPAYYFRFSWHALAGYAFWAFLQALLFWGLPGKKGLGQPTAGGNILSYKTNGLSAWFVTHAILGLLCLMGVVDPGYIPRNWINLWHVANVFGFLVSGFAFIKAHLVPSHIQDRKFSGSLLYDFYMGIEHNPRIGNDFDIKLFTIGRLGMVSWTVIDISNIAYQYQTYRIITPSLVLVTILHGIYVIDFFVHEDWYLRTIDIAHDHFGFYLAWGSIVWIPATYTLQAQYLGQFPTIVSRIYLIIVFGLGLAGYVVFRVANNQKDRVRSSNGNCVVFGQPPRYIRARYKTADGKFHESILLCSGWWGWSRHANYVGDLLMSFAMCALVGTTKLLVWFYGFFMLVLLIHRCLRDEKRCHDKYGKYWQEYCRLVRWRLIPGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBG4</accession>
    <name>R0IBG4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_43584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029499.1">
        <property type="nucleotide sequence ID" value="XM_008031308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IBG4"/>
    <dbReference type="STRING" id="671987.R0IBG4"/>
    <dbReference type="GeneID" id="19404858"/>
    <dbReference type="eggNOG" id="ENOG502RBZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
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        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA82740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="206" mass="23037" checksum="7EDCDBD030DE7B38" modified="2013-06-26" version="1">MVEKIYVTYNQVHKLCQEAAEQILNDFQPNLMIAIGGGGYVPARILRSFLKKPGSPNIPIQAIGLSLYEQLGSGPDADVETPGTKVTRTQWLDLSSLEMANLIGKNVLIVDEVDDTRTTLEYAVRELEKDVEAAVEKLGRQGEKTNFSIFVLHNKDKAKKGQLPQDILKGRYIAARTVGDVWINYPWEATDIDEHDRHSKEAESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICV3</accession>
    <name>R0ICV3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_22993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA83021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029399.1">
        <property type="nucleotide sequence ID" value="XM_008031208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ICV3"/>
    <dbReference type="STRING" id="671987.R0ICV3"/>
    <dbReference type="GeneID" id="19402619"/>
    <dbReference type="HOGENOM" id="CLU_103201_0_0_1"/>
    <dbReference type="OrthoDB" id="3762955at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="235" mass="26430" checksum="8AE5FA138E34F617" modified="2013-06-26" version="1" fragment="single">MNGQSSPYNNKKRSRDSENKPEKPCLCGDSHFWGQCPYIDTALQQRGFVVDPEKAKKIADFEAKDNRGILNKIREKNRRFKKSKTRDTNKHNKATDSDSIEIDAGDPLAEQSLQHEAYAVFFSAFNNQRVAQQYPLAHSWTLDPATDIHICNNPAEFEWKAPAADDDVVLAGGTETKIEAWGEVKLPLSTPSGIKRTTLKRVALIQSFFTSLVSLSRLSSSNIHFDSGRNVLYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0IDD4</accession>
    <name>R0IDD4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_33459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028784.1">
        <property type="nucleotide sequence ID" value="XM_008030593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IDD4"/>
    <dbReference type="GeneID" id="19403774"/>
    <dbReference type="eggNOG" id="ENOG502RIRI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2098346_0_0_1"/>
    <dbReference type="OrthoDB" id="3785399at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="116" mass="12244" checksum="C186F0DEA5081769" modified="2013-06-26" version="1">MSPAPPPHPSFPPLATFSPLRQHPALAHSRSLPSCAPCPDTAAALHAPSTLAAMYHLDGNPAPSDHTLFQDLLKMTTSKWQSLLKKDAVPVPGDASTRPSVSRSSTQLSVSKAKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGG1</accession>
    <name>R0IGG1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_93575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028489.1">
        <property type="nucleotide sequence ID" value="XM_008030298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGG1"/>
    <dbReference type="STRING" id="671987.R0IGG1"/>
    <dbReference type="GeneID" id="19406043"/>
    <dbReference type="eggNOG" id="ENOG502S3X1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_2_0_1"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="9"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA84091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="350" mass="38873" checksum="4FD6B8A9D2DE3853" modified="2013-06-26" version="1">MSHPLPRRIDVHSHFLPPFYRTALAENGHTFPDGMPAIPEWSPEYHLEMMSIANVSKSILSVSSPGTHIVAGNDALCRDLTRQCNAYAAQLKAQHPDKFGVWAALPLPDVEASLLEIETCLGEEAEGFGLMTNYHGNYVGAESMDRVFDKLNQIAATVFIHPTKPCIKQCHDTSSAQTTAALPLGDQYPVPIFEFFFDTARAVINLFSTGTVDRCPNIKFIIPHSGGALPPLMTRFIQFSSVVPGGRKLDAPTVRRQLETQFYFDLAGFAFDGLSGGNGQLKAFAQGFDFSYERFLYGSDFPFTQTQFVKSFADRMKDGLEHLYNEEERKAMYEGNAVKLLEQGKKKNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGS4</accession>
    <name>R0IGS4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_33199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028113.1">
        <property type="nucleotide sequence ID" value="XM_008029922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGS4"/>
    <dbReference type="GeneID" id="19403741"/>
    <dbReference type="eggNOG" id="ENOG502RXNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_427696_0_0_1"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="640" mass="68150" checksum="5B6FBA9FE1C324FC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHA8</accession>
    <name>R0IHA8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_93572</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028676.1">
        <property type="nucleotide sequence ID" value="XM_008030485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHA8"/>
    <dbReference type="STRING" id="671987.R0IHA8"/>
    <dbReference type="GeneID" id="19406042"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
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        <location>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908637">
        <property type="protein sequence ID" value="EOA85786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026580.1">
        <property type="nucleotide sequence ID" value="XM_008028389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILT9"/>
    <dbReference type="STRING" id="671987.R0ILT9"/>
    <dbReference type="GeneID" id="19395474"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="54"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="157"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="267"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA85786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44898" checksum="A0A2BF0CA8F40A5B" modified="2013-06-26" version="1">MSTHDPEPPSPTEVHDRYAPSALSVEPRDMSIPTKQRAWSSPIASLAVRIANLPDGSVNALCGASAGVASGIVTCPLDVIKTRLQAQGSFRPRKYTGPPRTVYKGLGGTARIIWLEDGIRGLYRGLGPMLLGYIPTWAVYMSTYDSTKNLLYPQMENKWLARTIASLVAGGCSTLVTNPIWVVKTRLMSQVSARASDDHRPPWHYKNTFDAFRKMYAKEGILSFYSGLTPALLGLTHVAIQFPLYEFLKMKFTGLEMGQTDAKVEDVHWFAIALATVLSKMTATSATYPHEVLRTRLQTQQRALPDHSDNHVTFRGGHHDQIHTRPPGTASSDGMINLPRYRGILRTCNVILQEEGWRAFYNGMGTNMVRAIPAAVTTMLTFESLKILHQKLKKEGKRIEEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IMC8</accession>
    <name>R0IMC8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_28548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026084.1">
        <property type="nucleotide sequence ID" value="XM_008027893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IMC8"/>
    <dbReference type="GeneID" id="19403254"/>
    <dbReference type="eggNOG" id="ENOG502R7UW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727936_0_0_1"/>
    <dbReference type="OrthoDB" id="3801597at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="380" mass="42804" checksum="DE9398511F6ABF38" modified="2013-06-26" version="1">MPYSLRSGNKLKRPARYRDESDDKVDSSTHPTSGNRDTDSQSQNDSLTDSMESASTANSTPPPSSFTPPAFSFTPPSPLFTHPTVVAPAATTNSSNLSNTSHPPPLQHPKMANTKIVKANPRRTDEHRETEPDDPPPAGNHTKNPNKISRRNRALALTPKFAFPKPAAFPSLPTDAPPPSQPESAATDQSSVHSMKELFEAIESQDQARVAAIKQSIDRMYRESENEWYAELRKRWSPDEVEEIVTFESLWYSVRNTIIEEIQADFTDIYHGSPFYPAQRILNLEMEKLVAIMKENMEVWTTEDEIPKYFQQYRRRHPDAIIDPDEPPPAEVVRAIRFLRQQSLPGSLLGEWHILPPVEVFRPPVMAEYPSKGPATVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0IN90</accession>
    <name>R0IN90_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_169336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026226.1">
        <property type="nucleotide sequence ID" value="XM_008028035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IN90"/>
    <dbReference type="STRING" id="671987.R0IN90"/>
    <dbReference type="GeneID" id="19400872"/>
    <dbReference type="eggNOG" id="KOG3769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034765_3_0_1"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000043">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsRNA-binding domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="102"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA86241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="411" mass="44712" checksum="FF0D8F78B5C2B0E1" modified="2013-06-26" version="1">MKRIPISRCASQLLAQPLPRRPSCPCAAAKNAQRGIAPHSHRIQARFQTTAAIPHDGDLEIEIAANSGASSAAALRPAGSQPLALESLPSPHPSAAERSIKLHALRSRLSLPPRFPLQALARTLVHPSADPNPAFNNASLSILGRHLLSYYTTEWIVCNYPRLPMAVVFAAVEAYIGPKALATMAREWGIEAAAEPGGEVDPGLLQFKRIQSGDDLPSSLKRQVPWSWNVTTTHKIMKTDEFGSENAAPGPHSLQNTGVPTEEAAQSFVRALMGALHQHLGSPLVKRFFRDHFLSRHLDMSKLFDFRTPTRDLSTLCAREGFEPPIARLISETGRLSRHPVFVVGVYSGKDKLGEGAGSSLTEARIRAAAAALKAWYLYKPVQVTVPSSTEGELDTSKWRPNYVDCGEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0INA8</accession>
    <name>R0INA8_EXST2</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_28658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86261.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0INA8"/>
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    <dbReference type="HOGENOM" id="CLU_785652_0_0_1"/>
    <dbReference type="OrthoDB" id="3440338at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="173"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="353" mass="39646" checksum="4E01FDC8339D86D0" modified="2013-06-26" version="1">MKQDNKVNRTLDSPLEYPAALLKSRFHRPEYLYTVVDGAQHLDECDNGTLDVFTKAGIEAHLSRKKDCNLNGLVSTYEDEKIALKRGKGENSVKLILRTSGLVPAWLTTGDIKIPIWVSQKTEGSPRVKHAQPNVWICLDEAKVVLDIPDHLCDKGEWLVHGHSIKQRAAERIATQHSRIPKRNTDVEAYGVFDDEEREGQDKRSNREQHHLVEDKHTENPSTKDTSYFLEEPCIPTRKSSLRSLKPKPSNPPPTATTQSPQLRLATRNATITLTNADQSHAASLMKYALLMAYGKKPEAEETWPLDTSSISSLSSPGARSENEDGEKQVWCENLEVNIDVDMQSESSELEAM</sequence>
</entry>
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    <accession>R0INK3</accession>
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            <fullName evidence="3">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_30879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SJKY">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RmlC-like cupins"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25697" checksum="1CC7F33A5870B882" modified="2013-06-26" version="1">MPIKVHSYKLPPTPLIPNSPYPLLHYPGLLKDTVTAPDFRPTQLLDVYAKNGWQTQWIAKYGPDIQSHYHSTTHEAMTVISGLGATIRFGVADSPSWEPALYPPGARGPDGEAGGVEIEARIGDVFIIPAGVSHKTFAPSPESLELAFHQPHDIEAGNARDVSAEAEAQRRAFFEQVRVNGEFMMMGAYPYGRVWDFKIGGEHEGREGDVWNLPIPESDPVLGESGEGLVGLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPT6</accession>
    <name>R0IPT6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_31252</name>
    </gene>
    <organism evidence="14 15">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the thioredoxin family.</text>
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        <property type="protein sequence ID" value="EOA87420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0IRA5"/>
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    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="19690at2759"/>
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    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
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        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA87420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="146" mass="15928" checksum="571CB2321581991C" modified="2013-06-26" version="1">MATEISAPLHFRTLLTAHTYLIADFYATWCPPCKQIAPIYSQLAGAHATPAKLAFVKVNVDEQREVAGQYGVTAMPTFMLFKDGNKVQEVRGADVRALRACVEGVAAQVKAGRKEVGEEEEGHKEEKTVSGSYGMTGGNHWKMSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRS1</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_31668</name>
    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1723460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="152" mass="17294" checksum="5D2D0C85D5CF1EDD" modified="2013-06-26" version="1">MYNNLTLIHVSVLCDICMSSRTDILVGDNNLHNDFWGGFNVRNVCHKGRIIGLFARQRTHNLMVNGTITYSRSYLRTDCKYDSAIDIARVSQELATRALGSCVIQDRGIKTDYRIIRLDMDMQPNCLAKRVRYITAQTTSTGSHNVQFKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0IUM0</accession>
    <name>R0IUM0_EXST2</name>
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        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_65532</name>
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    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908539">
        <property type="protein sequence ID" value="EOA88336.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IUM0"/>
    <dbReference type="GeneID" id="19405319"/>
    <dbReference type="HOGENOM" id="CLU_013929_17_4_1"/>
    <dbReference type="OrthoDB" id="3942738at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA88336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6312" checksum="E6EF575EE69C6405" modified="2013-06-26" version="1" fragment="single">MDPIQEAIAEIESRELGDKFSYQAIAKKHGVARMTLMRRHRGETEAYGVRNLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>R0IV96</accession>
    <name>R0IV96_EXST2</name>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_46320</name>
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    <organism evidence="5 6">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023349.1">
        <property type="nucleotide sequence ID" value="XM_008025158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IV96"/>
    <dbReference type="STRING" id="671987.R0IV96"/>
    <dbReference type="GeneID" id="19405044"/>
    <dbReference type="eggNOG" id="ENOG502S0WX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009353_1_0_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA88685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="796" mass="88735" checksum="A3E1511C62F4C320" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVI5</accession>
    <name>R0IVI5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_168042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023461.1">
        <property type="nucleotide sequence ID" value="XM_008025270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVI5"/>
    <dbReference type="STRING" id="671987.R0IVI5"/>
    <dbReference type="GeneID" id="19400403"/>
    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060791_0_0_1"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA88795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="260" mass="29256" checksum="3DA39B2179DB069F" modified="2013-06-26" version="1">MGQPVVQTIHRDPALFWWILLPITVVMILTGILRHYAMTLLQSTPKKQDLLKIRQQRSLVRGVNLRTNAHVISPSSFAARKAYMVQAFQEGKFLAEPDMRGKPRPNPMSDPAAMEGMMGMMKGQMTMMIPQTLIMGWINAFFSGFVIMKLPFPLTPQFKSMLQSGVGTRDLDVRWVSSLSWYFLTLFGLQPVYNFILGSNNAANQVTQQMAMANPGAGGIMGPEQDPDKLFLNEAENLEVLEHRWIMEGIEERLVAKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXU2</accession>
    <name>R0IXU2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SETTUDRAFT_128091</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023181.1">
        <property type="nucleotide sequence ID" value="XM_008024990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IXU2"/>
    <dbReference type="STRING" id="671987.R0IXU2"/>
    <dbReference type="GeneID" id="19396040"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_3_1"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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        <location>
            <begin position="49"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EOA89396.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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    <sequence length="654" mass="73059" checksum="C7D2B526F3280271" modified="2013-06-26" version="1"> </sequence>
</entry>
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    <accession>R0IY25</accession>
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            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008024414.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SJUN">
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    <dbReference type="HOGENOM" id="CLU_007003_1_0_1"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Notoamide_regulator"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA89630.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="688" mass="79381" checksum="AB6C32422D84CE7C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0IY57</accession>
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        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023258.1">
        <property type="nucleotide sequence ID" value="XM_008025067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IY57"/>
    <dbReference type="STRING" id="671987.R0IY57"/>
    <dbReference type="GeneID" id="19400371"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010580_1_0_1"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA89496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="584" mass="66845" checksum="D740CD11478C56F3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYK2</accession>
    <name>R0IYK2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_146681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022595.1">
        <property type="nucleotide sequence ID" value="XM_008024404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IYK2"/>
    <dbReference type="STRING" id="671987.R0IYK2"/>
    <dbReference type="GeneID" id="19396883"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_0_2_1"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="141"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA89616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="442" mass="48836" checksum="C94B1C154E32DD2E" modified="2013-06-26" version="1">MVARPRREDIRLHSKTTASREYHDKNAGKPDRVLTYISPPQQYGYQSPQPPYNSGYGQPTPPPQQYGYNQGPPPQQQFGNYGGPPPPPQQTPRPGMMPTATSNQWTHGNHNAPPPPPTGAQNFGQGAPNGYSFQYSACNGRRKALLIGINYFGQRGQLRGCINDVKNMSTYLNEFFGYKREDMVTLTDDQQNPMSQPTKANILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEDDGYDEVIYPVDFRTAGHIVDDEMHRIMVAPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGVLKEPNLAKEAGQGLLGIVSSYARGDIGSMIGGATSLFKKAMNGDEVYKKNLRTKTSPADVIMWSGSKDTQTSADASIGGEATGAMSWAFITSLRKNPNQSYVQLLNSIRDELEGKYDQKPQLSCSHPLSRSCRPTCQLRKHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZ80</accession>
    <name>R0IZ80_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_167589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="310" mass="34538" checksum="2204ED05BA36D2D7" modified="2013-06-26" version="1">MIAPSSAWVRVGLRRIPNASSRNTNTGNTCNLERACLRLRLSNASRRYNSTNPEGAQGASGAARTIPGPSWLWLDPIVEPFRAYGRVQQRRPYMTQLVSSLIIYFIGDCVAQSITQPEPSAQQPEPAEDDADEKGWVQKWSDERDWARTGRALVIGGLSAIPSYKWFLWLSKSFNYQSKILSLSTKVFVNQALFTPLFNSYFFGMQTLLSGASFSEIIERIRNTVPTSWWNSCKVWPAVTAFSFTYVPIQYRSIFSGVVAIGWQTYLNLLNQHAAAEEGMQHAAGHVAPVNIRTVHAHAEGGQGMQKCAA</sequence>
</entry>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="101" mass="11433" checksum="783C04FE822AC2E9" modified="2013-06-26" version="1">MPLNDSQRRVILEHADRLLSTRAWPKTICPSEIARAFSTAELEVLDASSWRETMDSIRQLLWDKRASGEVEVMQKGQVVVAESLEDIRGPIRVRMVKAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZY5</accession>
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            <fullName evidence="4">Thiol methyltransferase</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15230" checksum="AC3018F531D806FA" modified="2013-06-26" version="1">MSNYAQQPYGAPSRPAFSALQSSRTAAPGYDSSAVSSIASRSSTASAPPVSPSSSPQNQPYFGSLNQQSHQHQHQHQQQPQQPPRMQAQRHPSFEYQPNRSGAGQTAAETTNYLNQAALLAEAAKRAQMACVMRDLDGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1E3</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021540.1">
        <property type="nucleotide sequence ID" value="XM_008023349.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0J1E3"/>
    <dbReference type="GeneID" id="19399902"/>
    <dbReference type="eggNOG" id="KOG0430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_1_2_1"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 20" id="KW-0408">Iron</keyword>
    <keyword evidence="12 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="22">
        <location>
            <begin position="261"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="1293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="793"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="906"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="938"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1038"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1107"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EOA90800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1361" mass="149385" checksum="5763DC12D5F09F74" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1W5</accession>
    <name>R0J1W5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_36262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021275.1">
        <property type="nucleotide sequence ID" value="XM_008023084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J1W5"/>
    <dbReference type="STRING" id="671987.R0J1W5"/>
    <dbReference type="GeneID" id="19404109"/>
    <dbReference type="eggNOG" id="ENOG502QRP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010191_1_0_1"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="713"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA90751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="764" mass="83741" checksum="925A4B4ED844A63E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2Z7</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_158569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021753.1">
        <property type="nucleotide sequence ID" value="XM_008023562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2Z7"/>
    <dbReference type="STRING" id="671987.R0J2Z7"/>
    <dbReference type="GeneID" id="19397838"/>
    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF15">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="263" mass="29240" checksum="1643081D7316D1BD" modified="2013-06-26" version="1">MPFTYKTVLLVGATSGIGAGMADKLIMEGSKVIAVGRRQDRLDEFVKKHNSPKAASIQFDIADHEGVDSFFSKVIEEHPDLDCVFLNAGIQSQTRLSRPAEFDLGKFHQEINVNFTSIVNLAVKFLPHLQAKSTPTSLIITGTHLAIVPAVTLAAYSASKAALTAFVDCLREQNRHKPTKIIEIYPPVVQSELHDYAGPRGRTYGLPLGEFTERAYTELLKGDELIVIDSIAIEPRETYMDLLDRRRKIFTKLSKAMLGHFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0J333</accession>
    <name>R0J333_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_101713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48458" checksum="4ECB1120DBAFF708" modified="2013-06-26" version="1">MPSFQLAIITAIVLSFTLLYTICSLSARDPTSIFFDASKAYTPRYSALRSQQAKAHVSTYNSTFSPEYVTEKHIGKKLCVGIPSVARQGPQYLPGAVGSLLNGLTAHEREEIYLMVFIPHSDPATHPAYGEPWLSKLTDRILTYEELNTQDMNHVRTMETKGGMFEEKGLYDYSYILSKCAERNTPYIVILEDDVIAMDGWYHRTVNALQDAEEQSTQREKPFLYLRLFYTEAFLGWNSEDWKTYLFYSLCFAAMPAAVVSFLRATSLPGLLNKHTWPTEARTGYRRLVLTFYALMAAAILLFFALGRMTVLPLPTGVHEMPRFGCCSQAFVFPRQKALDLISYFAQTKTGYVDVLTERYADTRGELRYAVTPSVFQHVGTTSSKMGEYGPIFKQKTWSFGFEEYEANELRKEHEAAGSWLDGMGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JW60</accession>
    <name>R0JW60_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_32404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027026.1">
        <property type="nucleotide sequence ID" value="XM_008028835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JW60"/>
    <dbReference type="SMR" id="R0JW60"/>
    <dbReference type="STRING" id="671987.R0JW60"/>
    <dbReference type="GeneID" id="19403648"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_5_1_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="570"/>
            <end position="571"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA85178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="665" mass="74344" checksum="2C811BBE20FAE04C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWH8</accession>
    <name>R0JWH8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_91125</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027736.1">
        <property type="nucleotide sequence ID" value="XM_008029545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWH8"/>
    <dbReference type="SMR" id="R0JWH8"/>
    <dbReference type="GeneID" id="19405883"/>
    <dbReference type="eggNOG" id="ENOG502S2KQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_0_1"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF4">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353752" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA85313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="222" mass="23677" checksum="B0F7517803C267BB" modified="2013-06-26" version="1">MVAISSLLLGISAIAGSAIAAPTADVPDFELNTESKALIARQDYNQNYKTSGNVQFSPTNNGYSVTFSNAGDFVVGKGWKTGTTRKIKFKGSTKARAGTVLVSVYGWTTNPLVEYYIQEYTSNGSGSAQGQKMGSVTCDGSSYDIWKHTQVNQPSIVGTTTFTQYISNRVNKRPGSGTVTTSCHFDAWAKLGMKLGTHNYQTLSTEGWGNAGGKSQYTVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWN0</accession>
    <name>R0JWN0_EXST2</name>
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        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_137970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA85363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027773.1">
        <property type="nucleotide sequence ID" value="XM_008029582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWN0"/>
    <dbReference type="STRING" id="671987.R0JWN0"/>
    <dbReference type="GeneID" id="19396437"/>
    <dbReference type="eggNOG" id="KOG0963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016758_0_0_1"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="443"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="149"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="427"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA85363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="735" mass="81244" checksum="1845001F95E74DDB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWR0</accession>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_100338</name>
    </gene>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031334.1">
        <property type="nucleotide sequence ID" value="XM_008033143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWR0"/>
    <dbReference type="STRING" id="671987.R0JWR0"/>
    <dbReference type="GeneID" id="19394781"/>
    <dbReference type="eggNOG" id="ENOG502RXEV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014019_1_0_1"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA80682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="585" mass="65031" checksum="C0EB78189D3FF9B6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWV8</accession>
    <name>R0JWV8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_156859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030331.1">
        <property type="nucleotide sequence ID" value="XM_008032140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWV8"/>
    <dbReference type="STRING" id="671987.R0JWV8"/>
    <dbReference type="GeneID" id="19397676"/>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010913_2_0_1"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="13"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="454" mass="50209" checksum="FB78B2155E30BCF9" modified="2013-06-26" version="1">MRKLEYHMLKGLTYLDHGGTTLAPRSLLNSFCSEMQRTLLANPHSDASNPSATAIMVESVRLEVLKMFQADPEHFDVVFTANATAAIKLVAEGFSGLEEGFDYFYHRNSHTSLVGVRELACSNHCFTSNVEVVDWLADSVRATDVPQRPILFAYPAQSNMNGERLPLDWAKKLRLSANHERAYTLLDVAALVSTSPLDLSDHSAAPDFTALSFYKIFGFPDLGALIVRKAAGHIFDQRRYFGGGTTEMTTCTGDVWVARKDSSLHARLEDGTIAFRSILALKFAIATHRELFGGPGQVSKHTSWLARNLYERLAGSNHLNGMPMYRIYKAADSKYHDPKTQGATIAFNVCRSNGSYTGPWHVGCFLRRHDIHIRTGTVCNPAGMACALGLNSEWLRKAFEKGYRCNTEQDVVEQIPVGVVRVTFGAMSTLEDVEKLVSSLAHTGNGRAPKSNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JX49</accession>
    <name>R0JX49_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_97180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030388.1">
        <property type="nucleotide sequence ID" value="XM_008032197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JX49"/>
    <dbReference type="STRING" id="671987.R0JX49"/>
    <dbReference type="GeneID" id="19406289"/>
    <dbReference type="eggNOG" id="KOG3401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_0_1_1"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="135" mass="15207" checksum="5464D214A86F1589" modified="2013-06-26" version="1">MTKVQSMVASSRRKSRKAHFSAPSSVRRVIMSAPLSKELREKHGVRSIPIRKDDEITVVRGSNKGREGKVSSVYRLKYCIHVNGIVREKSNGQSVPIPIAASKVVITKLKLDKDRESILERKSAGREEKKKQREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXT5</accession>
    <name>R0JXT5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_151991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Leng Y."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">28A</strain>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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                <person name="Steffenson B.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Dhillon B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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</entry>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <strain evidence="3">28A</strain>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039743">
        <property type="entry name" value="6GAL/EXGAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767:SF1">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
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        </location>
    </feature>
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            <begin position="26"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="480" mass="53092" checksum="BE22BA0E6E692A8A" modified="2013-06-26" version="1">MRAPSFAEIAFVLVNGLLVSADTTTTIDAKSNWGTWEGWGTSLAWWAQQFGDREDLADIFFTLKDTTFAGQTLSGLGFSHARYNAGACSWNTIGTDKMVVSPNVKRSRQMEGFWLDWNSQDPNSNSWNWSVDVNQRKALQLAIARGVTKTELFSNSPMWWQTKNHNPSGSSDGSENIQSWNLEQHAVYMATVAQVFKSKYNIAFETVDPFNEPSANWWKADGTQEGCHIDVSTQAQIIGYLDTQLKNRSLSTKIAASDESYYDQAVNNLKTIGSSALGKIYRVNVHGYQGGSGDRVGVNSLATAAGKGVYNSEYGDGDATGQQMASNLILDFRWLKPQAWIYWQVLDQGGWGLINADNDAKTLGGPTQKYFVLAQFARHIRPGMRILDGGADNVVAAYDATNKKLVIVAVNWGSAQYLNFDLSKFKTIPQTNAPVTRWSTQIGSGEQYGKHSDTVINGTKFWSYFGTNVIQTFEVSNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4F3</accession>
    <name>R0K4F3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_111929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908748">
        <property type="protein sequence ID" value="EOA84439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4F3"/>
    <dbReference type="STRING" id="671987.R0K4F3"/>
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    <dbReference type="HOGENOM" id="CLU_000288_125_11_1"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
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    </dbReference>
    <dbReference type="Pfam" id="PF13424">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="11038" checksum="E672A8A7B3DDBF31" modified="2013-06-26" version="1" fragment="single">TYRNQGRWTEAEELEVQVMQMRKRVLGDEYPDTLTSMNNLALALQSQARRQEALALMETCFQLRQQVLGEQHHNTQSSFDTLHSWRAECINENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0K524</accession>
    <name>R0K524_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_93952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029174.1">
        <property type="nucleotide sequence ID" value="XM_008030983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K524"/>
    <dbReference type="GeneID" id="19406069"/>
    <dbReference type="eggNOG" id="ENOG502S77Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065432_0_0_1"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343829" evidence="6">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="157" mass="17083" checksum="A4F5C7019746B719" modified="2013-06-26" version="1">MACLLYPLSAPAQGVSAALCTTAFPALLALPTATNARTSLVYLSKQSSWLSSYLRHITTFTLFSAYVLSPRRFRHPYLLYTSIFAFVSGPGVDYAVTAMEGASEQRQVMELEAQGDAVNGELVREVVERRQRTERIKTALAGVAFAMQVVGLWGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5Z5</accession>
    <name>R0K5Z5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Double-strand-break repair protein rad21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_179527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
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        <text evidence="2 8">Protein modification; protein glycosylation.</text>
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    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
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        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008027796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAA5"/>
    <dbReference type="STRING" id="671987.R0KAA5"/>
    <dbReference type="GeneID" id="19395391"/>
    <dbReference type="eggNOG" id="KOG1746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111220_0_0_1"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="141" mass="15407" checksum="59EFDEA3EC6A8B28" modified="2013-06-26" version="1">MAPKQRSADSSARSSTPSRAAKASSSSSSNTSAPAIVQGVWDKYVSKTPQRTKLLDVFLVFLMAVGALQFAYVVLVGNFPFNAFLSGFSATVGQFVLTASLRIQTNQENKQHFESISHERAFADFVFGSLLLHFFCVNFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBC1</accession>
    <name>R0KBC1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_36875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021885.1">
        <property type="nucleotide sequence ID" value="XM_008023694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBC1"/>
    <dbReference type="STRING" id="671987.R0KBC1"/>
    <dbReference type="GeneID" id="19404190"/>
    <dbReference type="HOGENOM" id="CLU_1679035_0_0_1"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343205" evidence="2">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA90223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="157" mass="15390" checksum="5106029281557A27" modified="2013-06-26" version="1">MKLLSLCTSMLLATTAAAAAIAANPHSIYRRCPADTTAPDAMPTSIESVSPAPSSLPPATTTTLAPSPVASPTASPPPAPAAPSDDSSSSTSPQKTVTIAPGDTLEKIAAANGVGVCDLARANEIADPNKILAGSTLVVLGLAGDKDNSTCLEAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBP4</accession>
    <name>R0KBP4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_102979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022228.1">
        <property type="nucleotide sequence ID" value="XM_008024037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBP4"/>
    <dbReference type="STRING" id="671987.R0KBP4"/>
    <dbReference type="GeneID" id="19394954"/>
    <dbReference type="eggNOG" id="ENOG502S6HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1355400_0_0_1"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF1">
        <property type="entry name" value="IPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="202" mass="22610" checksum="88BBBFE6DEF76896" modified="2013-06-26" version="1">MEVLEFWKSPEYAARLKAKCESVCSETENRKNISDNNVFLPLPSTTVSEPKIHIQQAKTKVKKRGEPQLRDQTTPEHPTEIKCASDPIRVSKGKLSVFRRMFPEAVEERSAEVEWSTFVLSMNDAGFSSKNSGGSMVTFESKSGLGSIIFHRPHPSSKLDSIMLQSMGRRMNKWFGWNRETFALIGKDIEAGVALEGASVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBT0</accession>
    <name>R0KBT0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_177732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85657.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    <sequence length="474" mass="50930" checksum="C3EBF0EF332B6425" modified="2013-06-26" version="1">MFHEGSLQSGIARAIQEQKLVACFVRDNGATSNEWEQEWLKSGWLSSLLAQKAVLLRLEAGSTEAGFLAAFSDLAEIPTFVVIQNGQLQVQLKSNVTKNDFINSIRRVLGANPIPGSTPAPTTQEPSESPTTTAAAENDLYGADEPSPPIRAEPVAVAPTPSTNAKGKQKATSAPASKPTTSSGSVNKAQQEAREALRKKKREEAEELARVKARIEADKAARKAEAETRKAERERERNKAAQAPAPPRTITSSRPSQAKTVSLNVRLFDGRTIRSTFPREATLQGQVRSWVDTEFSKLAQDDENINHKQLPPYYFRHILAPQPSRELSAGDENLSLGDIDLAPSATLVLVPVKGYSEAYSVAEGGAVGLATGLMGTAFNLLASTVDFVGSAIGYGSSASTPGQQRSSGSGQTMASRPSQDTQRDANGDGAAGTSDRAGMRVRTLSDQRAREPQQFYNGNQLSTEPRPEDNDKRD</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBT6"/>
    <dbReference type="STRING" id="671987.R0KBT6"/>
    <dbReference type="GeneID" id="19402193"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Tyrosinase_Cu-bd"/>
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    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="399" mass="44570" checksum="285360DAE3974872" modified="2013-06-26" version="1">MRSSLAVIYSQLLATFAVAGVSLDSPSVPNIDINPALDPVEALNQLQNYTYTVLEQSNDVFKKTKKGCSLATATIRRDWEYMSKPDRKAYIEAVQCLRRLPSKSDKSWAPAARTRFDDFVAIHVDQSLYIHGNGLFLAWHRYFVWAYEQALRNECGYRGYQPYWNWFAHTDNIYESPVFDGSDTSLGGDGEYFSHNGSLAGGRTISIPSGKGGGCVNSGPFKNTQANIGPISPGMQGFPDLAADITDYNPHCLRRDLSPYIPRKWFTTANLLNVTIVSGSRTHSVFWTEILGRYPDGFLGLHTSGHYTMGGDATDLYYSVNDPAFWLHHAMLDRVYWIWQTLHPAEANKVAGTLTLQNKPPTRNATIDEPLDLGINGKTVKIRDVLDTMGGTPLCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023982.1">
        <property type="nucleotide sequence ID" value="XM_008025791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KH96"/>
    <dbReference type="STRING" id="671987.R0KH96"/>
    <dbReference type="GeneID" id="19397016"/>
    <dbReference type="eggNOG" id="KOG2630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023273_1_1_1"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
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    </dbReference>
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        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
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        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA88604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24593" checksum="06DED26AE718DFC9" modified="2013-06-26" version="1">MSAASLNHARWSQAEVIVLDIGKLARHAWADADFQTLIASFPPDCRQNPDALLAHVQDLTRRDIKAVYLKQLQGHLWTTGFRDGHLKTPLFEDVVPTLEAWKTAGKTLVIFSSGSVQAQLQFFSYVSDGPTSTRDIKPLFSAHYDTVNAGPKLQEASYHKICSDLGKHSDQVVFLTDNVKEAEAATLAHVYAVVVDRPGNASLSDAARARFPVIQKLTDLPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0KHH5</accession>
    <name>R0KHH5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_162757</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021174.1">
        <property type="nucleotide sequence ID" value="XM_008022983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KHH5"/>
    <dbReference type="STRING" id="671987.R0KHH5"/>
    <dbReference type="GeneID" id="19398519"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_4_0_1"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000167">
        <property type="entry name" value="Uncharacterized mitochondrial carrier C29A3.11c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="260"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA92338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40024" checksum="6D70C9A02554016A" modified="2013-06-26" version="1">MPKQEDQRPTLQRGAPPRPRDLTDISSAVLRSEQAKRWTKRYRTEVAASSSSLLSTFAAYPLDSVKTRLQAYKFNSFTDCVRHTYRTEGFHGFYRGVWSPLASITLVRTVSFSIYQRSKYALDNWIYQTTGSSPLVIANTKGAWPTLSTVTCFGLAGVNAGGAITIIACPFELTKLSAQISVLMAERNDGGGKNDAIRKSYQNLGTWKTAQNLVRHRGWRGLYSGFHLHLLRDSIGTGIYFVTYESVKQVLANARGTSPTHPLAVVIAGGLCGLVSWACIFPIDTAKSIYQRNCLVGGRDKATRPKIQFFNRRMYQGLGVSMSRSCIVNAIFFTAFEFLKKRINSMTYDEELLRAYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJA6</accession>
    <name>R0KJA6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_108275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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        <source>
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</entry>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="91" mass="10030" checksum="A3DA769484BB7AFC" modified="2013-06-26" version="1">MRDIAIIGQLRKAVPVPGYSGSGKVPDTSTVQVIVQDQIGVSRDPSSAPKKRPHVQHNDCIKEIRSLVGHTQSPEWYQKVFGSNITPNRRA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKM1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0072546">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Beta_sandwich_EMC7"/>
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        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344416" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA88522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="239" mass="25960" checksum="528256D36996435A" modified="2013-06-26" version="1">MKTSFAALASFATLTSAARLLLQIPNTALVNPATLPSTTHATLQSSGPPLDAYLTRSNTFNFNNISVGSYLATIHCRDYAFEPLRIDVALEEAVEGSGEMKEVIKAWQTFLGNEWDNKGEIRGEGGNGLVIEARPVGPKYFYQERQGFSPLSFLKNPMIIMAVVSMGLIFGMPKLMENMDPEMKEEFEEMQKNGVLGSGTTNTAQQLQNFDLASWMAGKTDSGSASATTQSSAGQAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLN7</accession>
    <name>R0KLN7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_168101</name>
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    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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                <person name="Han J."/>
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                <person name="Han J."/>
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                <person name="Barry K.W."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Han J."/>
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            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020848.1">
        <property type="nucleotide sequence ID" value="XM_008022657.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0KS21"/>
    <dbReference type="GeneID" id="19398371"/>
    <dbReference type="eggNOG" id="ENOG502RZWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5432at2759"/>
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    </dbReference>
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        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA91779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="209" mass="22460" checksum="B50A7F0ABFF1C871" modified="2013-06-26" version="1">MTHFLRSKHDAILIGVGTAVADNPSLNCRIEGVGGYGGEGLAGQPRPIVVDPQGRWQFSEESKVLKLAGESKGKAPFIVTHVEPSDDRRAILENVGGKFLVLDPAPKHTTETSSLWHRILDALKEHDIQSVMIEGGGFVINDLLGPGPAYSLVDSVIVTIAPVWLGKGGVQVCPDGGPERLPVTRLRDVRWVPLGEDVVLCGRPNQALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTJ7</accession>
    <name>R0KTJ7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_101354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021739.1">
        <property type="nucleotide sequence ID" value="XM_008023548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTJ7"/>
    <dbReference type="STRING" id="671987.R0KTJ7"/>
    <dbReference type="GeneID" id="19394847"/>
    <dbReference type="eggNOG" id="ENOG502S7M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036529_1_0_1"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="289"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="401" mass="44184" checksum="286B3EEA0B308262" modified="2013-06-26" version="1">MPRLRSRAAPASLTPHSATPTASSTRPRRSTANQSPAAATIQRSSPEETRQSIHLTVKSSPNKLRQAIGGSLSKAGVSRQNIVAGKRASRNSRVVQEVDSDEDDEDEDEDEDEDDVDEADAMDVDDDSDDNEDAQGDDDDEDMDAEGDEDDEMEDTPAPRITVSSHRSIPVKSAPAGSLTKAQDKVEAKEMAMDDDDDEELSDPDSDLDDEDAEGEDEDAEGEDDDDIGVTPAEMDEDMDSDEDLSRDQTPDVTKMTKRQRALVTDDADGGLLALSNEAQKKKHLTAEEHAMRRAEMARRRKNLSEKRNEEEKLDTINRLLKKQPPKRGRKAQQDASEEGLEEPEPERANPLFVRYIQNAKGTQLAVPEEWLQAPVGSLFAGDTQKEAQKPFSGKMVEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0I545</accession>
    <name>R0I545_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_181893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031337.1">
        <property type="nucleotide sequence ID" value="XM_008033146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I545"/>
    <dbReference type="STRING" id="671987.R0I545"/>
    <dbReference type="GeneID" id="19401875"/>
    <dbReference type="HOGENOM" id="CLU_707887_0_0_1"/>
    <dbReference type="OrthoDB" id="3798900at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="358"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
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    <dbReference type="eggNOG" id="ENOG502QVDP">
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    <dbReference type="OrthoDB" id="3548913at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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                <person name="Dhillon B."/>
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                <person name="Kosti I."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="PubMed" id="23236275"/>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Manning V.A."/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46206:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="12"/>
            <end position="34"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        <location>
            <position position="454"/>
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        <ligandPart>
            <name>Fe</name>
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    </evidence>
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        <source>
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            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA84451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="58994" checksum="786803020C1ECE85" modified="2013-06-26" version="1">MEMKTSPVIAQIVQAVTAAAITYFAYTYIIHLNYKRHLARIPRLRSQQIGSNEETRQTYLKSAKALYREGYENFKDQVYRMSNADGIDSVVIPRKFLDELRRLPDNTLSAGKAVADFLEVKYTQILAEEDIVAHTIKADLTPSLLRLTPIISEVADKAIQGDMPSCEDWTPVCIYGLLTTIVAKMSGRIFVGPDLYLDEKYLEMGIQYTHELMAAQRRVKNMRPLLRPLLAHRTPEVRQLRKREKLAKEFFTPVVEARLQGEKRDDWKEPDDMLQWLLNRREQFKLDTMEKISKLQLGIIFTAIHTTVMTATNIFYSLVVTPEYIHELREEILQALANNEGIMNSKALQEMEKVDSYMKEVFRFYNFGTISFLRKVLKGIVLSNGQYIPAGVNIEAPTYSIYHDDHLYPDAHTFDGFRAYKMRKNTMLDEVSARNHFVNVNDQNLGFGYGRHACPGRFFANNEIKLILAKLLLEYDIKMVDGMTTRWPNIEHGAECLPDPSKEILFKRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIY4</accession>
    <name>R0IIY4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_32146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIY4"/>
    <dbReference type="GeneID" id="19403631"/>
    <dbReference type="eggNOG" id="ENOG502RZ6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011910_0_0_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="857"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA84906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="882" mass="100129" checksum="69A0BD98B14815F6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJ57</accession>
    <name>R0IJ57_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_172112</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027634.1">
        <property type="nucleotide sequence ID" value="XM_008029443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJ57"/>
    <dbReference type="STRING" id="671987.R0IJ57"/>
    <dbReference type="GeneID" id="19401158"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011815_0_1_1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="17"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA85170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="325" mass="36435" checksum="481257A974B958F7" modified="2013-06-26" version="1">MTSTPPNSALKRSQKPPSGPNVLEVVLGSLLIKPWYPSFYPEELVGKRAERLYVCQWCFKYSKELVGFLGHLKACPLRNTPPPGVNVYTKDNYSLYEIDGEKNKLYAQNLSLFAKLFLDTKSVFYDVTTFLYYLLVAHNPTPPVPNTNLSDDTTPGDTGVSGQVVGFFSKEKMSWDNNNLACILVFPPWQKQGLGQLLMGASYEMSRRENRLGGPEKPLSDLGRIAYNHYWSQTLARTLLSSPSKKTLTVQELREKTYIVPEDIIATLQMMDVLEQKKKGGADAVINKAKVRAWADTHKVDVKSCPVDPEAFISRELSRGGSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJD1</accession>
    <name>R0IJD1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_179766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027702.1">
        <property type="nucleotide sequence ID" value="XM_008029511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJD1"/>
    <dbReference type="STRING" id="671987.R0IJD1"/>
    <dbReference type="GeneID" id="19401711"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353092" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA85265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="457" mass="50149" checksum="D63F7ABB92CDE4B4" modified="2013-06-26" version="1">MRPSTLFIGALGLLSPITTSALELNVDDPASIKQATKVVAAGLREWYTGDRPGDVPGNLPDPYYWWLCGAMFGSFVDYWYYTGDDTYNKITTQALVHQIGQPKAFMPPNQTSTLGNDDQAFWGMTALSAAENKFPDAEGEMSWLSLAIAVFNTQVPRWNNKTCGGGLNWQIFPFNKGFDYKNTISNGAFFNIAARLAKYTKNDTYTEWAKTAWEWEQSIGLVDKDYHFYDGSSEKQNCTEKNHIQWTYNAGIHMSGAAALWNMSEAQGNTAQAAYWRKHLDGIIDNIGIFFSPDGAPNVMTEAACERNGLCDHDQRSFKAYLARWMGYTMLNAPYTREKLMPKLKTSAAAAAAQCSPGKGGCGLRWWQGKNDGQVGVGEQMSAMEVMQNLLIDQVAGPVGLDTGGVSKNDPTAGTDPGPLKIQHGAIKTGDKVGAAFLTVLVAVIFFGGGWWMTTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJR5</accession>
    <name>R0IJR5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_164038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Kosti I."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">28A</strain>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the NRP synthetase family.</text>
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    <dbReference type="HOGENOM" id="CLU_000022_37_4_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00833">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
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    </dbReference>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
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        <property type="entry name" value="Polyketide synthase dehydratase"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_adenyl_dom"/>
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        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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        <property type="entry name" value="ANL_N_sf"/>
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    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
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    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
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    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
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    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
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    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
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    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
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    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
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    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
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    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
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    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
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    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KR"/>
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        <property type="entry name" value="Methyltransf_12"/>
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    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
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        <property type="entry name" value="PP-binding"/>
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    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PKS_KR"/>
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    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="13">
        <location>
            <begin position="5"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="14">
        <location>
            <begin position="952"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="3568"/>
            <end position="3643"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2504"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2511"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="10">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="10">
        <location>
            <position position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA87505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4039" mass="439326" checksum="B1259F7CE5FF9C47" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISI5</accession>
    <name>R0ISI5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_28099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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    </evidence>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Manning V.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <text evidence="2">Belongs to the ORC5 family.</text>
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    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="152"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="376"/>
            <end position="385"/>
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    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Manning V.A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Tu Z.J."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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            <strain evidence="8">28A</strain>
        </source>
    </reference>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="370" mass="40075" checksum="0BFEF8E5AE7818DB" modified="2013-06-26" version="1">MARINLPPLTRGILATLVFCTLLNFALRPNANWVEKVEKPIIGVGNGVPWLAIVPRRSVPWYPWVFALATVVEQNLLGLIITGLTVFYGGRYLERAWGSHEFTKFMLFVAMIPNILSYLLYAVGYLVVGKGSMVNTTISGGIAIQAGFLVSFKQLVPEHTVAIAKGLIRMRVKHFPAIFLLANTISGTILGTETAMFLAYFGFMTAWIYLRFYRISPSLSSTATGDGSVIRGDASDTFSFAHFFPEPLQTPIGAFADGVYNMLVSLKVCTPFSDHDIDAGNEQASARAEGGLPSIMNPNSRGGRGGGTRAEAERRRALALEALNQRLNAAASRTSSFPAPATVSVSGPSESLGETNYEPDRPEMSEKSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2W0</accession>
    <name>R0J2W0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_166914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA91081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008023542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2W0"/>
    <dbReference type="STRING" id="671987.R0J2W0"/>
    <dbReference type="GeneID" id="19399977"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_0_1_1"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable glutamine synthetase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="124"/>
            <end position="488"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA91081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="488" mass="54356" checksum="3F870EB28FAD4ED2" modified="2013-06-26" version="1">MAADFDPSTLTADQLPELLKNDLAVKVAGIDVDGMLRGKLMAKKKFLSIASEGFGFCSVVFGWDMHDKTYFRELAISNKENGYRDLVAIPDLSSFRRIPWEDNVPFFLVSFYDPDTKASLSACPRSLLKRAVDKLKENGYGAMAGAEYEFYQFRAPQSHDGSEKNTSSTASFLRDNPVDALPSLTEGMFGYSITRPVHNQEYYYGIFNACAQFGCGIEGWHTESGPGVFEAALEFGDIQSMADKASLFKLVVKSLGSKFGITPCFMAKPREGLPGNSGHMHVSIVDKEGKNLFYRGEEDKNAPYPDIRHLSDLGRHFLAGLIDGLPDIMPILAPNVNSYKRLVENFWAPVTVSWGLEHRAASIRLIAPPTASPKATRFEVRVPGADTNPHFVLAAILALGWRGIEKKMEISIPPLGKGEDVGSETDKGERLAKSLKEATERFMRKESVAREVFGDQFVDHFGGTRQHEIRLWDEAVTDWEVRRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3L9</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_152458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020599.1">
        <property type="nucleotide sequence ID" value="XM_008022408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3L9"/>
    <dbReference type="GeneID" id="19397192"/>
    <dbReference type="HOGENOM" id="CLU_2997938_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343349" evidence="2">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="57" mass="5784" checksum="94B22293A1604C4A" modified="2013-06-26" version="1">MVATAWCWGLSYLVGCGVTGALSALDKGSRWTLAPKGLGNKAGRQAGQTGDDDDVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3N0</accession>
    <name>R0J3N0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_132872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lucas S."/>
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                <person name="Ciuffetti L."/>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>heme</name>
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    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
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    </dbReference>
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    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="202"/>
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        <ligand>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="6">
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J4I1"/>
    <dbReference type="GeneID" id="19403428"/>
    <dbReference type="HOGENOM" id="CLU_478153_0_0_1"/>
    <dbReference type="OrthoDB" id="3644322at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="578" mass="63248" checksum="DFC5242C850EE454" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0J5D0</accession>
    <name>R0J5D0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_74773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020333.1">
        <property type="nucleotide sequence ID" value="XM_008022142.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0J5D0"/>
    <dbReference type="GeneID" id="19405390"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_1_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="424" mass="47222" checksum="5A4BFDED8239ED8E" modified="2013-06-26" version="1" fragment="single">TLETFRIMGLRKEFEEAITVITGTDFAPDERVTSLLQTTQLLSALLSAYDITTCKDARLLSKAMEVGDMLYTFFDTPNRLPVTRWNATKAANGEEQQVSQHATLADLTSYSLAFTRLSQLTRDMRFYDAVARTITILASQQSRTRIPGLWPADINLQNLDLTSSNTFNLHTTSHSAYAHSALMTRFLGTSSAASPYTTVSTNALDATIRHLLFRPITPTNASILMASTAYTTPKGHITRTHTIDASSCALGSTLALSAALTHNDTHLAYARLVTEGCIWTSLHAPPSPLGHINAMPESFSMLACSSAALKNSAQNCTFEPAVWPTQVYPGFEKVWDAKRTTVRPEMVMSLFALYRVTGEERWRDVAWEMWTSVERVVAARLEQLRDEEELRMTTQTLKFFYLLFGDPAMFSLDEWVFGSDGHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0JHB6</accession>
    <name>R0JHB6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_143783</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031402.1">
        <property type="nucleotide sequence ID" value="XM_008033211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JHB6"/>
    <dbReference type="STRING" id="671987.R0JHB6"/>
    <dbReference type="GeneID" id="19396726"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Dhillon B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11013" checksum="E5C5874F7382278E" modified="2013-06-26" version="1">MTVYDNTGAPGACGVNLTDDMLVVAIAQSAWDAKGGSTYNVMTGASSNPWCGTEIEVKYNGASVKAKILDLCPGCKGPDDVDLSRGAWKALGLTEATRLKASWSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJY9</accession>
    <name>R0JJY9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_98593</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031027.1">
        <property type="nucleotide sequence ID" value="XM_008032836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JJY9"/>
    <dbReference type="STRING" id="671987.R0JJY9"/>
    <dbReference type="GeneID" id="19406383"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07836">
        <property type="entry name" value="STKc_Pho85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="151"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA81613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="470" mass="52255" checksum="BD3E829D0B569A80" modified="2013-06-26" version="1">MPSTCSHSCLLSAAPTSPPSRRPPPTHACPPTHSVYSSTGPYLIAGPRRRPRCITTSHIVKTAPPAPAPADDAPRSSSPLRIARQLTTASAILWDPKFTSRPPPASLKPVHAGTLVAPQRTDSSISVRSLGDGDGVPLVPTMDNRRHPSSFQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLDSEEGTPSTAIREISLMKELRHENIVLLHDVIHTENKLMLVFEFMDKDLKRYMDSRGDRGALDPATIKSFMYQLLKGIAFCHEARVLHRDLKPQNLLINNRGQLKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAEMYTGRPLFPGTTNEDQVQKIFRLMGTPSERSWPGISQLPEYKNNFPVYHTQDLRLILPQVDQVGLNLLNSMLQLRPEMRISAANALQHPWFNDLPQRQQEVAQMQAQAHAQAQQAQMGGGYQVPQNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0JMT0</accession>
    <name>R0JMT0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_140681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029639.1">
        <property type="nucleotide sequence ID" value="XM_008031448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JMT0"/>
    <dbReference type="STRING" id="671987.R0JMT0"/>
    <dbReference type="GeneID" id="19396573"/>
    <dbReference type="eggNOG" id="ENOG502R6VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020422_0_0_1"/>
    <dbReference type="OrthoDB" id="5300765at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65963" checksum="31B1D3A2158F088D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JP48</accession>
    <name>R0JP48_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_121619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029954.1">
        <property type="nucleotide sequence ID" value="XM_008031763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JP48"/>
    <dbReference type="STRING" id="671987.R0JP48"/>
    <dbReference type="GeneID" id="19395855"/>
    <dbReference type="eggNOG" id="KOG2901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024840_0_0_1"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000004">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA82978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="525" mass="57242" checksum="39AA2150DF5148C1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0JQ15</accession>
    <name>R0JQ15_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_164700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029031.1">
        <property type="nucleotide sequence ID" value="XM_008030840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQ15"/>
    <dbReference type="STRING" id="671987.R0JQ15"/>
    <dbReference type="GeneID" id="19399209"/>
    <dbReference type="eggNOG" id="ENOG502S3W3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086393_1_0_1"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA83273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="161" mass="18388" checksum="C9375B90FD1803E8" modified="2013-06-26" version="1">MGMPYNIITNATTAITNDYGIEARRYSDSSTESDLCEMVRFEEQKGAITDYIEMWDYVGGIMFRGFVVEREEERSMFVFFDEAVIAADLKAGLMALLELCEVDYFSCGRLVLCIDRHADQAARNNLTKDLGWIGFGLTTLDEFSQGDELTSEKWLFMDMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0JQK6</accession>
    <name>R0JQK6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_140026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029166.1">
        <property type="nucleotide sequence ID" value="XM_008030975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQK6"/>
    <dbReference type="STRING" id="671987.R0JQK6"/>
    <dbReference type="GeneID" id="19396533"/>
    <dbReference type="eggNOG" id="KOG1813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050460_0_0_1"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="228"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA83453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="308" mass="33917" checksum="0EE47B17A84A31F8" modified="2013-06-26" version="1">MDTPVVKFKKRGAKAAPRKAAPPPPQSDSDFSSGEDAEGEDGRVVKRRKTNANALKASTADRKTNATVEGTTQYAANTDAVIEASNDATKQSNWYDEKAEDALSSKNLLGSTRSKPQSFIDKNPDAPTRQVGPMKASTNIRTITVTDYTPDVCKDYKQTGFCGFGDNCKFLHAREDYAAGWKLDREWEMSTKGKKPGGTIVASANRDEKDKDEDGIDLALLEKIPFACIICKKPYKSPVVTKCGHYFCEACALKRYRKDPTCAACSAKTYGVFNGAKNLQKLLEKKQKWEDKKKAEAEEKAKEEEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JQS6</accession>
    <name>R0JQS6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_94736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029206.1">
        <property type="nucleotide sequence ID" value="XM_008031015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JQS6"/>
    <dbReference type="STRING" id="671987.R0JQS6"/>
    <dbReference type="GeneID" id="19406121"/>
    <dbReference type="eggNOG" id="ENOG502S1MK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051552_0_0_1"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000032">
        <property type="entry name" value="CTD kinase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031560.1">
        <property type="nucleotide sequence ID" value="XM_008033369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JTY2"/>
    <dbReference type="STRING" id="671987.R0JTY2"/>
    <dbReference type="GeneID" id="19399791"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="392"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA80994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="808" mass="89922" checksum="93C66AE85B6A4682" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>R0JU61</accession>
    <name>R0JU61_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_31829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026967.1">
        <property type="nucleotide sequence ID" value="XM_008028776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JU61"/>
    <dbReference type="GeneID" id="19403589"/>
    <dbReference type="HOGENOM" id="CLU_1661871_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="159" mass="17930" checksum="A1B7E6E826FAA27A" modified="2013-06-26" version="1">MVFKAPAPDAPTAEQWQRMLMATQLQYTPTQCWPIHLPDESFSFPFAASSGFLQQHQRRQLFECMPTEDVQCVLALNLPDSHQQLEDCANSPSPSSLLPRTSTSSTEICFHTHRAAPSQPARWLSIAERHVYDASRKAQVPLAMYAHGHVSRDGVSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUM6</accession>
    <name>R0JUM6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_20254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JUM6"/>
    <dbReference type="GeneID" id="19402311"/>
    <dbReference type="HOGENOM" id="CLU_1732610_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="151" mass="16787" checksum="D08131CEC309A0EB" modified="2013-06-26" version="1">MADNGRHGVAVAVTVTVTVTVTVTGTQRDDSWSDCAICSGAKPNACCWPAGPSPVTRHSRQAGRMTASASPAMFVVLDSLLRLKEEAWVTEWVAKCVNQSPRTRLRQWRGWSDSITQACRASGYRWLHGKALEEFEYDVLEIEMDRQKCQV</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
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        <property type="protein sequence ID" value="EOA84823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="671987.R0JUX0"/>
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    <dbReference type="GO" id="GO:0022625">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
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    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
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        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA84823.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="110" mass="11906" checksum="7909E220D7AA545C" modified="2013-06-26" version="1">MAPKKNKRTADSINSRLALVMKSGKVTLGYKSTLKSLRTGKAKLVIIAGNTPPLRKSELEYYAMLSKTSVHHFSGNNIELGTACGKLFRCSVMSILDAGDSDILSTNTEN</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908659">
        <property type="protein sequence ID" value="EOA85663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028503.1"/>
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    <dbReference type="AlphaFoldDB" id="R0JXN4"/>
    <dbReference type="STRING" id="671987.R0JXN4"/>
    <dbReference type="GeneID" id="19404587"/>
    <dbReference type="eggNOG" id="KOG3431">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_122978_1_0_1"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA-binding TFAR19-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15395" checksum="0EB6DF7DB539DDFF" modified="2013-06-26" version="1">MSDEDLEQIRRARLQQLQQQSGGRGSGGQGSEQESRKQAEADQRASILSQILLPEAADRLGRIRLVKESRATDVENRLIMLARTGQIRQKVTEEQLKEILGAVAEQQDKEEQKIVVNRRGGGWDDDDELEELMKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYE8</accession>
    <name>R0JYE8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_23637</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030592.1">
        <property type="nucleotide sequence ID" value="XM_008032401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYE8"/>
    <dbReference type="STRING" id="671987.R0JYE8"/>
    <dbReference type="GeneID" id="19402693"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011977370" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="774"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="716"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA81257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="870" mass="93097" checksum="405EDFBFDE81D4EC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYH6</accession>
    <name>R0JYH6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_165035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029635.1">
        <property type="nucleotide sequence ID" value="XM_008031444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYH6"/>
    <dbReference type="SMR" id="R0JYH6"/>
    <dbReference type="STRING" id="671987.R0JYH6"/>
    <dbReference type="GeneID" id="19399336"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:melatonin binding"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA82524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="361" mass="39646" checksum="8239D62A61C44C8F" modified="2013-06-26" version="1">MVQATEVLSRKTGVIVGEDIEKLFKHAQSEGYAIPAINVTSSSTVVAALEAARDSKSPIILQLSNGGAAYFAGKGVANSNQEASIAGSIAAAHYIRSIAPSYGIPVVLHTDHCAKKLLPWLDGMMDADEAYFKQHGEPLFSSHMIDLSEESKEWNIATTKKYLQRAATIKQMIEMEIGITGGEEDGVNNEDVDNNSLYTQPEDIYDIYKELSAVSPLFSIAAGFGNVHGVYKPGNVKLRPELLQKHQAYVKEKTGSKDDKPVFLVFHGGSGSSVDDFRQAISYGVVKVNLDTDMQWAYLSGIRDYIQSKSGYLQTQVGNPDGDDKPNKKYYDPRVWVREGEKTMSKRIKVALDDFYTTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZD1</accession>
    <name>R0JZD1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SETTUDRAFT_165213</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029820.1">
        <property type="nucleotide sequence ID" value="XM_008031629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZD1"/>
    <dbReference type="STRING" id="671987.R0JZD1"/>
    <dbReference type="GeneID" id="19399387"/>
    <dbReference type="eggNOG" id="KOG0455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_0_1_1"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="18">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="159"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="97"/>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
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                <person name="Grimwood J."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008030734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K446"/>
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    <dbReference type="eggNOG" id="ENOG502SAHG">
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    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
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        <location>
            <begin position="111"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="385"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="385" mass="41747" checksum="CB365881418C19AA" modified="2013-06-26" version="1">MSNWFGDLDLAYKYVLVFVSLLVITIIGGFIKVLYNRQKLRKAVKTELEAGPKEDTVELNQREKDEGDLFGIRAIEAGFYAGVAQSRPTSRAGSVMSDHAAMSNSTLVGGSVNSPLMKGQSNNNSTLSLNLNATSDSTRRTSPPTVKLRPSEAELTGRHHMVDMSLQVPPSPGLPRGSSSPTFDMSDNDHDDFGRSYSPSGQSPYNPPTGKLPTIPNIAMSKERRSPSPENTYPRVQVHEPNYAPALSLSATPGRVEPQAYSAQHERGGSDASSHYYSSAKRGWHEADGRSAERQVSVSTTMSGGRTSSIFASVASDDEHEQGPTQPPSSTLLVPAPVGGNDGRLSEFYEAYYRNEHYRTEHAFDRQSAMGDDDASPAATPTVFK</sequence>
</entry>
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        </recommendedName>
    </protein>
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            <taxon>Pleosporales</taxon>
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            <taxon>Exserohilum</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K450"/>
    <dbReference type="GeneID" id="19396503"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019748">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29594" checksum="C8A2B7510EE65902" modified="2013-06-26" version="1">MASIAKEIALITGANSGIGFEIAHQLLQRGNYHVLLGSRNSNKGAAALQDLQSRNLPGSIELMHLDVRSDEHISQTATLIKEKHGKLDILFNNAAVAIPEGATERERLAAAFDINATGPWLLTKSVMPLLKKSENPRIINISSGAGSIGRRLFSESPMYKIQGAPYRASKVAFNMLTACLHVEFGLGVKQIDMTGTEPSQGEEGTEDEEKRNMTVFCYDPGFTVSNLGPHNKPEFGARSAEKTVNSIMELVDGKRDEEVGKFIHNTGEYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4P8</accession>
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        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_160546</name>
    </gene>
    <organism evidence="7 8">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA88033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008025959.1"/>
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    <dbReference type="AlphaFoldDB" id="R0K4P8"/>
    <dbReference type="STRING" id="671987.R0K4P8"/>
    <dbReference type="GeneID" id="19398054"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_026673_16_2_1"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
    <sequence length="426" mass="46056" checksum="7D28E3FB8274AB31" modified="2013-06-26" version="1">MDHQHEFQRTSGKSSLPKIQRALLLHGVRQPYVTSRDTKVPGVHHDYELLVKVNAAGLNPIDWKAPDYNFGIPTLPYISGRELVGTVIKASKSSNSRIHEGDIVIIPSTDYRDLRKAAFQEYSIASAFNTIRLPTHISINSGSILGVAFVSAVLSLGICMGVSFEDVENGPDLLNIVKNIDPERLPVDIRQECLDSIERSERAKSGDWLVIWGGSSTCAYVAKQLARLVGLKIISVVDGAKHGLRLSSTPSIRPDLVVDSHNPTRAVEIIKAATNDGARFGLDTVGKETAGHLLTSLSFSPSSEPLLAKDENGNAKRKDSKLLSPPATPLEITSGARRSHLVGLTGLPKTGIPGGVVPHNVPIKLYHEIPEVGEALSAWCERLLVQGLLVPPEVVGTVNGLEGINEGLDRMRRNEIRGGRLVAILP</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908548">
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA88248.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="411" mass="42669" checksum="5FBDA89738E235F9" modified="2013-06-26" version="1">MDSASTHINMGTQHGYIDSADDMSITEAVLADMDFGDVDEPVPLVKNDGLKAIPMEQLAAEWDAMWTAQDAAAEDTTAVPRGELECGGDGGSTIVATETGSGGQVSVDKPSVNEPSVDHEQALKPESKTSPNTQEENEAAEKDVAKVTPDAVVHVEDATEHSDLPGITVDTASNDVIDEPSPAVDPVQGPQKAEPTETKIATQSSDDVTGSHDAAPVATTMHAAAAPEKAADSASPVIRPSSPGTLFCTPRAPKHAGKQHLGVGKNTIQVSNLYQGLESLDASQEGMESGNEDGGDGEEDENPAPADEAPVDEWPIKDQGPGPAAAASKKAKRGKRGKRAGKKVQLKRAKALAVVEEEEMEMEAEAKAKAVGIVETSTLLDVDEPHVAPAGLLVLALSVVAAFVGAWIEGY</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000016935">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="91"/>
            <end position="110"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="110" mass="12190" checksum="3C4CCE9EBDDE58D0" modified="2013-06-26" version="1">MPCDTHGGPCDNHYVMKTHDFSFLCTPPTKHCPGRAYGQILHYSPDQDCIAHHVHAKPGSGPWSSNRMHIIPTTIYTYVATSGMETDHVSAARDGDYNQLRGGVEPRDPK</sequence>
</entry>
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    <accession>R0K5Z7</accession>
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            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
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    <organism evidence="3 4">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="Grimwood J."/>
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                <person name="Han J."/>
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                <person name="Bushley K.E."/>
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        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_177420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026210.1">
        <property type="nucleotide sequence ID" value="XM_008028019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9Z0"/>
    <dbReference type="STRING" id="671987.R0K9Z0"/>
    <dbReference type="GeneID" id="19401534"/>
    <dbReference type="eggNOG" id="KOG2541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050129_0_1_1"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344304" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="327" mass="36451" checksum="4C9CE223E524E817" modified="2013-06-26" version="1">MLRLLPISTLLLVTQTLASPLAHGESKPLPLLIWHGLGDNYAADGLHSVGDLANETNPGTYVYYIRLDEDAGSDRTATFLGNVTEQIAQVCDDISEHEILSQAPGLNALGFSQGGQFLRGLVERCGDRVNIKNLVTFGSQHNGIAKYQICKDGDWLCKGYIGLLKANTWGTWVQGHLVPAQYFKATNETTGEPTDEYLEASNFLADINNERKLKNVTYAKNLAALDNFVMYMFEDDTTVIPKESGWFAYTNLTSNEVTDLRDRDIYREDWIGLKKLDEKGGLHFKTTKGGHMQLGDKVLRDVFKTYFSPKGTEWSGAMENAHDVMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA98</accession>
    <name>R0KA98_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_159456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022795.1">
        <property type="nucleotide sequence ID" value="XM_008024604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KA98"/>
    <dbReference type="STRING" id="671987.R0KA98"/>
    <dbReference type="GeneID" id="19397937"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35165" checksum="FA11FCF040548530" modified="2013-06-26" version="1">MASPLPYNRQNALASSIAADNASSIAAKIVLTTGVTQGGLGATFVEEIAKHGPQLIILAGRSPAKVQATADKIKADPASANVQVRVLTLDLASQKQIREAAKEVLEYREDRIDVLVNSAGTMGGEYRTTPEGIEHHFGANHVGHFLFTNLIMPKLLAAPAPRIVNVSSDGHRMSGVRFEDPNSQDGRVYDKWEAYGQSKTANILFTNALVDKLGHRGLRAYALHPGQTLGTSLAVSFTDEDMAASVEVKDKEIGWTREFDIKSLDECAATHVVAAFDPRLDDHNGAYLHDGNIAPEEVRPTAKQPGDGEKLWKLSEKLVGQEFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBU0</accession>
    <name>R0KBU0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycoside hydrolase family 132 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_37050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="1">Cell wall</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the SUN family.</text>
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        <property type="protein sequence ID" value="EOA90413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502QPVV">
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    <dbReference type="HOGENOM" id="CLU_033459_1_0_1"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="SUN"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA90413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="455" mass="49148" checksum="05A6200A29EF5BD5" modified="2013-06-26" version="1">MKLQHVITVTAIVAVTSAKPHHLHRRAHAHGPVKRDIVYAPAATQTQIVYWLEDHAISEEEAREGIANGTLMWGQDNVLSSATDTSVALPTPPPSSSHEPAPEQIEYHIEEPDDAPQSQPEMPAAETPLATPNPPDAPNIQQPDASPRPWIDMVDENGYCAECDREFPDGKIACTEFPHGYGALPIAHEGLGGWSGIQDPQYVGSDGFDDITTVVKGSCSDGTCCTPGSFCSYGCPNPYLKASFPSIQGKHGQTVGGLYCNKDGYFEMADGKIANTLCVQGSKRMGVKVQNKLSKSVSFCRTDYPGTESMTFPVTVGPGETGFLANPDQQKYFFWQGKKTSAQYYVNKQGVPEDEACTWGKEMGGKGNWAPAVFGTSFDDGPAQQGFSSLKQNELCKKERLGYDITFVGDGVVSACRYKSATNQWCEGGQCWEDPDRGCTAAIMHGDLTVVLSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBX1</accession>
    <name>R0KBX1_EXST2</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_169625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908648">
        <property type="protein sequence ID" value="EOA85717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026663.1">
        <property type="nucleotide sequence ID" value="XM_008028472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBX1"/>
    <dbReference type="STRING" id="671987.R0KBX1"/>
    <dbReference type="GeneID" id="19400969"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="387"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
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            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="548" mass="60627" checksum="38798CA24F16E711" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBY5</accession>
    <name>R0KBY5_EXST2</name>
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        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_37091</name>
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    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021910.1">
        <property type="nucleotide sequence ID" value="XM_008023719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBY5"/>
    <dbReference type="STRING" id="671987.R0KBY5"/>
    <dbReference type="GeneID" id="19404215"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090726">
        <property type="term" value="C:cortical dynamic polarity patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180040">
        <property type="term" value="P:negative regulation of pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA90453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="356" mass="40787" checksum="54ACABEFD1CF0307" modified="2013-06-26" version="1">MCFGRKPSTADPNARKNAEIEKTLRNDKKRAEREVKLLLLGAGESGKSTVLKQMRIINAGGFQSLERKTWRATIFNNLVSAFQTIFQAMQEDDTDFEDEDNIRYSEMVNTAPDIGTEEPMPDEFLTAFNCLWADKGVQLTILKGNQYALHDNLNYFFQDIDRLFHKDFLPTDQDILRTRLRTTGISETIFELGNLTYKMVDVGGQRSERKKWIHVFDNVQVVLFLVAISGYDHVLVEDRNGNQMHEALMLFESISNSRYFEKTALILFLNKIDLFAEKIAGGMSPINKTFPDYTGGATDFDAGKEFFANKFRNLVRQPKKEVYVHYTNATDTNLLKITMASVQDMIVQRNLNALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCE0</accession>
    <name>R0KCE0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_103266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022375.1">
        <property type="nucleotide sequence ID" value="XM_008024184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCE0"/>
    <dbReference type="STRING" id="671987.R0KCE0"/>
    <dbReference type="GeneID" id="19394975"/>
    <dbReference type="eggNOG" id="KOG1624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483963_0_0_1"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KE65"/>
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    <dbReference type="eggNOG" id="ENOG502SZN2">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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            <begin position="1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="80" mass="8415" checksum="C9F653E8C72DA2B2" modified="2013-06-26" version="1">MPVHPAEETASGNITDQVAKESSDSTASTHQHHDTDTHATSGGSLHAQAHKANPGPVVADNLPTPASKEELKKRAEELNQ</sequence>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="304" mass="31434" checksum="C0B7FEAEBA58AAC9" modified="2013-06-26" version="1">MPRNGDGSSDNGPIEGHEILHGMTGDDSLQHTKHAAPMPAAEHGDALPGMSGGGTAATVPVSINGTQQSDVVEASEESSSTSISKKRTEPHHASPERSQLDQKFTKLDADEVDIAAAQTESQERGARAQRRSDALGETKSEKQQKMGGTEEASKFGGHADVEALHGAATLEGDKSSEGAGKTKKQGNGAVEVHDADMLQRKKAEKFGGVNLENEGQTTANASKPTGENGGAHAGEHGETHVNGKEQQIGTKTAGRKDSLPVDGKESGHAMDGKGSGNGAVEVHEADKLQRSKAAKFGGVNLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEM6</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
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            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
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            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
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    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
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    <dbReference type="EMBL" id="KB908570">
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    <dbReference type="OrthoDB" id="498204at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0047545">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA87779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="414" mass="44382" checksum="CF56414B72190846" modified="2013-06-26" version="1">MFSLRALSRAKPTTTHHPRTLCRAFASSTRLNADFTHAVVGGGVVGLAIARKLQSRPSASTVLIEKHSAAGTETSSRNSEVIHAGLYYGPSSLKTKLCLRGKQLLYELCAKHGIPHRNTGKWIVAQDASQMGALEQIHDFAKSIDVPTRFLSKNEASTREPDVRAEAGVLESASTGIVDSHSLMQYLEGDFENSGGICAFNSPVTRITPIDAGRGGWEISTTTATTNDGDDDDTTSITAETLINAAGLHAVALSNSILPADRQKKAFYAKGSYFSYAASRPRVNTLIYPAPVPGHAGLGTHLTLDLSGRIRFGPDVQWTDSPSDYAPNTASLPAAIADIKLYLPRVDPTAIAPDYVGIRPKLGKLAATSGPDFQDFYIVREQGFEAWVNLLAIESPGLTSCLAIAEEVERLLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0KF40</accession>
    <name>R0KF40_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYB transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_41277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025107.1">
        <property type="nucleotide sequence ID" value="XM_008026916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KF40"/>
    <dbReference type="STRING" id="671987.R0KF40"/>
    <dbReference type="GeneID" id="19404684"/>
    <dbReference type="eggNOG" id="ENOG502RZP2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039317_2_0_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="125"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA86717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29529" checksum="BAC1859CEF1F1781" modified="2013-06-26" version="1">MSQHSPSSYNVGYPPPQQAAGRKRSHQDDLPHDLAPSLEQQLNPYAQAAGSVSLQHATQSYSMQQYPPPPPAPQSTLPPTHHHHLPSSHRNKRHHTMEGAPPSPSHHHGPPSVVGQEGMPAPAQRPRGPKLKFTPEDDQLLVDLKEKKNLTWKQIADFFPGRSSGTLQVRYCTKLKAKTTVWTSEMVDKLRNAMQEYENDRWRIISSKVGSGFSPAACRDKAEELQAVELAQQEAQEGEHSQLQHQSAYAPSQMGPDSSDSGARYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFP5</accession>
    <name>R0KFP5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_163046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025491.1">
        <property type="nucleotide sequence ID" value="XM_008027300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFP5"/>
    <dbReference type="STRING" id="671987.R0KFP5"/>
    <dbReference type="GeneID" id="19398634"/>
    <dbReference type="eggNOG" id="KOG2016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019618_1_0_1"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="18"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA86942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="563" mass="62332" checksum="63B03115AE422B52" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFW8</accession>
    <name>R0KFW8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_171288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025529.1">
        <property type="nucleotide sequence ID" value="XM_008027338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFW8"/>
    <dbReference type="STRING" id="671987.R0KFW8"/>
    <dbReference type="GeneID" id="19401091"/>
    <dbReference type="eggNOG" id="ENOG502RX75">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008809_0_0_1"/>
    <dbReference type="OrthoDB" id="5340195at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF3">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="748" mass="83671" checksum="E2EB8141A152DE48" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>R0KIB5</accession>
    <name>R0KIB5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SETTUDRAFT_168909</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024657.1">
        <property type="nucleotide sequence ID" value="XM_008026466.1"/>
    </dbReference>
    <dbReference type="SMR" id="R0KIB5"/>
    <dbReference type="STRING" id="671987.R0KIB5"/>
    <dbReference type="GeneID" id="19400717"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_0_2_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1189"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1587"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1613"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1642"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="22">
        <location>
            <begin position="1"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="940"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="23">
        <location>
            <begin position="1785"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="592"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EOA87782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1845" mass="205618" checksum="15F1BE7676BA6507" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKK7</accession>
    <name>R0KKK7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SETTUDRAFT_183936</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">28A</strain>
        </source>
    </reference>
    <reference evidence="27 28" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA88512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008025720.1"/>
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    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
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    </dbReference>
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        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
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    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Alpha-helical ferredoxin"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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    <sequence length="198" mass="21604" checksum="1053A3918C762BF6" modified="2013-06-26" version="1">MDLDKDNANPTILNPSDLPSRRSHATAKRQHHGATGLFDDLIPRYTYLSDPLDEPMSPADSDTDDAPEAIDEQEIYDLISTICDPEHPLSLGSLSVVNLPDIHILPPASPLSNISTVVVEITPTITHCSLATVIGLGVRVRLEQALPPRFRIDVRIKKGTHSTDKQVNKQLGDKERVAAALENGTLMGVLKKMLSTCE</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
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        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        <location>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
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    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
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    <dbReference type="GO" id="GO:0005850">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="180"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="312" mass="34459" checksum="FFB7AABEBD6BC660" modified="2013-06-26" version="1">MADTAEVTERKPRKSVQFSEGATIVDSNGDVTKSMELNGGKDSAEGHSSGGVGEDKEVDEVTDMFADLAKKKKKKSTKKKEGEEEEGAEGDFAALKKKKKSTKKKVEDDFEAKLAAAGGEKAEGEEEAAVAEPEVQEGDMMKGTGIWQHDQTTPISYNLLLSRFFTLLHAQHPDLASSGTKSYKIPPPQCMREGNKKTVFANLAEICKRMKRSDEHVAQFLFAELGTSGSFADQKRLVIKGRFQQKQLENVLRRYIVEYVTCKTCRSPDTDLSKGENRLNFVTCNSCGSRRSVQAIKTGFSAQIGKRRRMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPB8</accession>
    <name>R0KPB8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_101609</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021606.1">
        <property type="nucleotide sequence ID" value="XM_008023415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPB8"/>
    <dbReference type="STRING" id="671987.R0KPB8"/>
    <dbReference type="GeneID" id="19394868"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_6_0_1"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="296"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA90899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="691" mass="76511" checksum="B3A689CD71E1D743" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPD9</accession>
    <name>R0KPD9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_167527</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022663.1">
        <property type="nucleotide sequence ID" value="XM_008024472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPD9"/>
    <dbReference type="STRING" id="671987.R0KPD9"/>
    <dbReference type="GeneID" id="19400208"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA89712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="463" mass="50843" checksum="9EAB8C6BD2DAD3DF" modified="2013-06-26" version="1">MSGQHCLRRLPAAMRSVRALRPSPRSTPAARTYSAVARANSSGLLSQASRRPGQLSTQRLCTLDHIRTYADTIVKVPDMAESITEGTLKQWSKQVGDHVEQDEEIATIETDKIDVAVNAPEAGIIKEFLVNEEDTVTVGQEIVRLEPGAAPEGGKKEASEQPKEPAPESQETSSQPEGQQEQSQPEAPKEESKPEPKQETPQPPKQESKPQPPKKESKPEEPKPATPGSREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSSIMEFRKLYKDEVLKNKGVKLGFMSAFSRACILAARDVPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNAESMDMVGIEKAIADLGKKARDNKLTIEDMAGGTFTISNGGVFGSLMGTPIINLPQTAVLGLHAIKEKPVAINGKVEIRPMMYLALTYDHRLLDGREAVTFLVKVKEYIEDPRKMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQW9</accession>
    <name>R0KQW9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_132977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020639.1">
        <property type="nucleotide sequence ID" value="XM_008022448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQW9"/>
    <dbReference type="STRING" id="671987.R0KQW9"/>
    <dbReference type="GeneID" id="19396174"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="79"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
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    </evidence>
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        <source>
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    </evidence>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Bradshaw R.E."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
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        </location>
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        <location>
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        <location>
            <position position="53"/>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="342"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA91927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0KW59</accession>
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        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_178329</name>
    </gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA91987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022781.1"/>
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    <dbReference type="GeneID" id="19401604"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:late endosome to vacuole transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
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    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
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    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1973"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="3066"/>
            <end position="3171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="846"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1396"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1583"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1739"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
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        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1583"/>
            <end position="1596"/>
        </location>
    </feature>
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        <location>
            <begin position="1776"/>
            <end position="1797"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA91987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="3197" mass="359772" checksum="12AAEE75692E818B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KX61</accession>
    <name>R0KX61_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">SETTUDRAFT_162721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008022955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KX61"/>
    <dbReference type="STRING" id="671987.R0KX61"/>
    <dbReference type="GeneID" id="19398502"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="195"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA92297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="616" mass="69900" checksum="D1BCF7D0FEBF0D08" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9I0</accession>
    <name>R0I9I0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_181287</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030369.1">
        <property type="nucleotide sequence ID" value="XM_008032178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9I0"/>
    <dbReference type="STRING" id="671987.R0I9I0"/>
    <dbReference type="GeneID" id="19401836"/>
    <dbReference type="eggNOG" id="KOG1514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_5_1_1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9M9</accession>
    <name>R0I9M9_EXST2</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="11" type="ORF">SETTUDRAFT_165605</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">28A</strain>
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    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">28A</strain>
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        <text evidence="1">Belongs to the CEF1 family.</text>
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    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
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        <location>
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            <end position="54"/>
        </location>
    </feature>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="780" mass="87224" checksum="C3F338EBEB317D0A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0IA47</accession>
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        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
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        <lineage>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030475.1">
        <property type="nucleotide sequence ID" value="XM_008032284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IA47"/>
    <dbReference type="STRING" id="671987.R0IA47"/>
    <dbReference type="GeneID" id="19397691"/>
    <dbReference type="eggNOG" id="KOG0884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="165" mass="17974" checksum="6B3FFFBE7570B108" modified="2013-06-26" version="1">MSVTLHTTKGDIKLEVFCETVPKTAENFLALCASGFYAGSPFHRIIPSFIVQTGSPASDPKSKTSASIFDTPNQLFDDEIRPALRHNARGILSMANKGPNSNGSQFFITLAPAPHLDGKNTVFGKVLEGWEALDDMEQVHVDKKSRPQERIEIKSVTIHANPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBS7</accession>
    <name>R0IBS7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450 monooxygenase ABA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Abscisic acid biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cytochrome P450 monooxygenase aba1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_165250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Hormone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029859.1">
        <property type="nucleotide sequence ID" value="XM_008031668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IBS7"/>
    <dbReference type="STRING" id="671987.R0IBS7"/>
    <dbReference type="GeneID" id="19399404"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000076">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00067672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="521" mass="58709" checksum="3C78E29D0BC830A8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0IC83</accession>
    <name>R0IC83_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_95734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="331" mass="37130" checksum="ADF7BA5A57DB4078" modified="2013-06-26" version="1">MENCSSQMCKAFGWDGSPDLVGVGMLATYTIQAILVTLYLFAILGVRLDKLPPQVQSSRILSRTLHSVQHSTAEFLSASSVFSLSILIASIISISYYEELRPMTWILALIISLNSVFPVAILHISTSTMLRRSKGRVFMWFIIDILLIGLTVRSSILFAEFSAYDAWIEYETNPCARISLHGIAVFSHIIAGFLCLGITGYIVDFMVSVIRNRPAMMVRLPDIAQWGVVGVCICTMWGFLGWLLNLAIKIQSRAGDNNKDSEWTFGQVLSLATWVPFVVEFAYIWWEDPLQALHGRLMAPYEVVVSSREQSLLEMRPSGGDEARGRFQRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IDZ8</accession>
    <name>R0IDZ8_EXST2</name>
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        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_164782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029104.1">
        <property type="nucleotide sequence ID" value="XM_008030913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IDZ8"/>
    <dbReference type="STRING" id="671987.R0IDZ8"/>
    <dbReference type="GeneID" id="19399239"/>
    <dbReference type="eggNOG" id="ENOG502SIMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_2_2_1"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA83371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="414" mass="47387" checksum="23193AC2A4B81E65" modified="2013-06-26" version="1">MRTRPRPPPPKLHLKIAMRPSSPIVSHFSGKLTSQVRRVLPAYLALIFLFLFFAHTEFFTTPIRAASRYKRELKYQQPLQAAGSVIPRKIWQTWKVGPLGFEQRDSDSAKTWPAKNPTYRYEVLTDDNANEYLEWHYGSHGFGRKDLVDLYKELNITIIKADLLRYLVMYAEGGVYADIDVECLRPINRFIPERYNEPDIDMIIGVEIDEPTFADHEILGGKCKSFCQWTFAAKPRLPVMMRLIENIQDWIHQLAKEKDVPISQLQLDFDEVIGGTGPSAFTKAVLQQMTAQNNGNPVTWDLFHNLAESRLVNGILVLNVEAFAAGQGHSDSGNHDSRGALVKHHYHASGWPALHPRRNHPMYGEVEHCNWKRECVDEWDKNVAEWDTLSKEEQEKRLASKPAPPTVPRQALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0IFG1</accession>
    <name>R0IFG1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LPS export ABC transporter periplasmic protein LptC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_172567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028434.1">
        <property type="nucleotide sequence ID" value="XM_008030243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IFG1"/>
    <dbReference type="GeneID" id="19401189"/>
    <dbReference type="eggNOG" id="ENOG502SYZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134552_1_0_1"/>
    <dbReference type="OrthoDB" id="3439489at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031755">
        <property type="entry name" value="Inhibitor_I66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16850">
        <property type="entry name" value="Inhibitor_I66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342344" description="LPS export ABC transporter periplasmic protein LptC" evidence="1">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17264" checksum="8D91E12E84AAE24C" modified="2013-06-26" version="1">MPAETNRRRNLLWALGIFCLILVSFRVYAAKEMDSLPAPFTIEIDGTPIAKAPADAADRTQAHIGTEPAAVFELKDKRLQSDGHILARALSEDRSFSPKKVMWFKADTTVPVYDVVAAQDGEDYSLQFSGAGLMASDGQVFADIMGTNPSRVVVKMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0IH25</accession>
    <name>R0IH25_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_164493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
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        </reaction>
    </comment>
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        <property type="match status" value="1"/>
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    </feature>
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    </evidence>
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</entry>
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            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025131.1">
        <property type="nucleotide sequence ID" value="XM_008026940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IR01"/>
    <dbReference type="STRING" id="671987.R0IR01"/>
    <dbReference type="GeneID" id="19404708"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF15">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="38"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA87106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="474" mass="51201" checksum="418EA53F6A1BBF6A" modified="2013-06-26" version="1">MEPATAPEFNPAKPNGGNPNQENVNLQYTGLEFHYIYLMIMAFLVFLIIPGIGFLYSGLARRKSALSLLFQSFAVMGVTTFQWMFWGYSLAYSRTASAFIGNMDNFGLKNVMSAPSPGSPLLPEIVFCLYQLLFCACTVQLVIGGSFERGRILPSMVFAFCWATVVYCPIACWTWNGNGWLFNLPSLDFAGGGPVHIASGWSALAYAFVLGKRLHKGDKIHGKAHNPTLVFIGTVFIWFGWFGFNGGSALNGTIRSMVAAFNTNTAASFGVIGWVMVEYVRTKGHFSVVGACSGAIAGLVGITPAAGYVSLWIAALIGFLTGVICSLCQNVDKWIRIDEGMDVFKLHGIGGMVGSFLTGIFAQSWVYDLDGMGPYDPLGAMDGVGVQVGRQLAEITAIASYSFVVSCILLYILKFIPGMHLRVTSEAEMMGLDLDQFGDEQIGDWSLMDQNHYEANASSASSQHATAVAAGKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRJ4</accession>
    <name>R0IRJ4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_20012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024985.1">
        <property type="nucleotide sequence ID" value="XM_008026794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IRJ4"/>
    <dbReference type="STRING" id="671987.R0IRJ4"/>
    <dbReference type="GeneID" id="19402272"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF15">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA87495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="491" mass="52965" checksum="8D7B84A8226052CE" modified="2013-06-26" version="1">MESHQSLQALLSSKNVPTISNSSSNWASLIDPYNRRLKYTPAAVTLPTTAQHVSDSILCAVAAGVKVQARSGGHSYGSFSLGGQNGSLVIDLRNLNTVSLDKSTGIVTVGGGARLGNLGLGIYNQGQRALPHGTFPGVGIGGHYTHGGFGYSSRRWGLALDTIVAMDVVLADGRFVHVTPTSHPDLWYALRGAADSIGIITTFYLQTQPAPAQVVNYSANFSSALKSADAAANVILTLQNFATTSPYIDRNLTVEVYTSVLGEFIVRGWYFGDLDYFSKTVFPAMLNGMATPPDNTTVEEQAWLTALEGIAEGEPLAEPLTGYNRRGTFYIKSIVTREAQPLTKAALTSYYQYIIDKGLTAQFFWNTFISLYGGKDSQINKPAADSAAYSHRDSLWVFQNIGSSPNRLPPFSPEITTFVNGLNTAITAPQPDGNFLAYPNYLDPALTPAEAAHLYYGRSTYSKLVKIKSDVDPNDVFWNPQSIGNAVLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IRP9</accession>
    <name>R0IRP9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_39334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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    <dbReference type="OrthoDB" id="3678099at2759"/>
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    </evidence>
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    <sequence length="276" mass="31320" checksum="E88715361D7AEF3C" modified="2013-06-26" version="1">MSDATTVGSEHGGMAPPRCRLLELPGELRNRIYVCVLEGTSCRVRPRPPPYPLRLAFRTPSRTLHWSLLKRQSLGLTQTCRKIRGEFLPLHRAHAPVKLQSMRELQRYISDFFVSAAAACGQCSLRLPLKEQAHDVLALIRALDSAPGLLLHWTDMPRWDRTNLAALIDVKGNRVWGEYVNQFVTGIWYYGDLSVYYQLVVELKDTAAEPWMLEKSGSNSARQDDSVHENRPHQKSEAVKKWLEMVGLQNIDRDLDSVQIQVAETEKSAVCQTNTT</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <feature type="non-terminal residue" evidence="2">
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            <position position="1"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA87436.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="49" mass="5779" checksum="CE900DAFE0053DB6" modified="2013-06-26" version="1" fragment="single">NVQYLVQKSGQRLTVDAHTLTRNARFLPHAYAPNTEKDQRERKKNNNKE</sequence>
</entry>
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    <accession>R0IV66</accession>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_27449</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">MFS-type transporter; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="EOA88645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025535.1"/>
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    <dbReference type="STRING" id="671987.R0IV66"/>
    <dbReference type="GeneID" id="19403128"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0015137">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0140115">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug resistance transporter"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="338"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA88645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="491" mass="53478" checksum="29DF9E41ECE33C7B" modified="2013-06-26" version="1">MAAVPNDDKPEPVPLDEAAVVPEVPVKGEVEVPYSIYTNREKWMIVAMVALAGFYSPLPANIYFPAIPTLARAFGKSADDLNQTVTVYLVFQGISPMLWGPISDRYGRRLVYLVCLSILVASSIGLALCPTNSFWLLLFLRCFQSGGSASTIALGAGVIGDISTSKERGGYFGMFNLGPMLAPCIAPAIGGALSQGLGWRSIFWSIVIMVAVCLLCIALFLPETLRSIAGNGSIPVPRIQRAIIPIVGQKATKEAFDPETRTKPKHSVNPFVLFTYPDVIVLLTFTGLVYAVNYTITATISSSFAKIYPQLSQTALGLCYLPVGAGMIIGSTLTGKMLDWEYARIKARCGDNFTIEHARLRIMPFYLSLFIVCVIAWGWTIQARAHIAVPLILGILLGWTSIGILNTTMTLNIDILQSRSSGATACTNLVRCSLAAILVAVIDRMTSAWGDGWTYTLWGAICCCLLPLMFLEIRMGPKWRKRREAKELDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>R0IWI7</accession>
    <name>R0IWI7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_106188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023595.1">
        <property type="nucleotide sequence ID" value="XM_008025404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IWI7"/>
    <dbReference type="STRING" id="671987.R0IWI7"/>
    <dbReference type="GeneID" id="19395153"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_1_1_1"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="656"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA88971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="732" mass="81923" checksum="C23B5F2E03A358D3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IWM1</accession>
    <name>R0IWM1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_168204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA89001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023618.1">
        <property type="nucleotide sequence ID" value="XM_008025427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IWM1"/>
    <dbReference type="STRING" id="671987.R0IWM1"/>
    <dbReference type="GeneID" id="19400462"/>
    <dbReference type="eggNOG" id="KOG1780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_10_0_1"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008025013.1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="58" mass="6661" checksum="F19C8CD1A5994DAD" modified="2013-06-26" version="1" fragment="single">MILVLQLRVRAKTSKECFFGYKKAVVRKKNGNYIRARADRQVDDDDDICRPSRGGTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0IZ91</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <location>
            <begin position="66"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA90310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
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    </dbReference>
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        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="204"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="407"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA90231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="599" mass="65875" checksum="EF96FE92AACC1ABA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0L0</accession>
    <name>R0J0L0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_167208</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022184.1">
        <property type="nucleotide sequence ID" value="XM_008023993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0L0"/>
    <dbReference type="STRING" id="671987.R0J0L0"/>
    <dbReference type="GeneID" id="19400077"/>
    <dbReference type="eggNOG" id="KOG3230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="222" mass="25412" checksum="4CF7DA014E03793A" modified="2013-06-26" version="1">MNIVEWAFGKRMTPAERLRKHQRALEKTQRELDRERVKLENQEKKLVADIKKSAKNGQMGPLRIQAKDLVRTRRYIQKFYQMRTQLQAISLRIQTVRSNEQMMQSMKGATTLLGSMNRQMNLPALQRIAQEFEKENDIMDQRQEMMDDAIDDATGVEDEEESEDVVNQVLDEIGIDLGQALGETPSGLQKNTVPETRVAQAIGGGGDPDDDDLQARLDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0Z1</accession>
    <name>R0J0Z1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_167291</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022284.1">
        <property type="nucleotide sequence ID" value="XM_008024093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0Z1"/>
    <dbReference type="STRING" id="671987.R0J0Z1"/>
    <dbReference type="GeneID" id="19400121"/>
    <dbReference type="eggNOG" id="ENOG502QRZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_1_0_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA90441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="442" mass="47044" checksum="17B5D3B9B4B81A85" modified="2013-06-26" version="1">MAASAAASPSPVQKRAITPITVKGNAFWAGNERFYVRGVDYQPGGSAKAADPIADADGCKRDIAEFKKLGINTVRVYTVDNSANHDTCMGLLADAGIYLALDVNTPKYSLNRAQPQKSYNKVYLQSLFATVEMFAKYDNTLLFFSGNEVINDDKTTDCAPYVKAVTRDLKSYINARGLRQIPVGYSAADVESNRYEMAAYMNCGDNSTRSDFFAFNDYSWCDPSSFTTSGWDNKVKKFSNYSLPIFLSEFGCNTNKRTFEEIKTLYSSQMTSVYSGGLVYEYSQESSNYGLVEIDNGQVKELADFQALKSAYSGTPSPQGDGGYRASGSPSECPTQSSTWDVTLKADQLPAIPSGASDYFKNGAGKGPGLTGDGSQEAGSSESNIADAGNGAVTTGGVSPSGTSTPKKGAASSVRPMDFSLAPLVAGAVVLASSLFGGALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0J199</accession>
    <name>R0J199_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_24871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021209.1">
        <property type="nucleotide sequence ID" value="XM_008023018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J199"/>
    <dbReference type="GeneID" id="19402847"/>
    <dbReference type="HOGENOM" id="CLU_712033_0_0_1"/>
    <dbReference type="OrthoDB" id="3800116at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="399" mass="44903" checksum="1362355C78DD0714" modified="2013-06-26" version="1">MPRNKHQLTIDTAYANMPYVFTHASNQKSASSKETPSPDDQTFLLSPTSSEGNFYLESPVLPQSRRENPFATPNISDISTGCGSFQTFQTLADELLISQPNTASHMVDILPDSASLYAEEEFHEWDWQNVQPDAQQPCGIEVNVSMDPEVQGPLPIIHDEDFPPGLPAEEYQYLRKQQQRQHLESQLRSRSNTSPYFTHSPTYSQTAFQQAGLAHAQRVHISEVRNATRKALGANFDFADEKDRGNGGGRTVQRRPAHTSTTTTPRPRERMPQHHVDALSARWSEAEMQEQYARSRAARMQQNMHGATTASVSRRRDHSRAHDDSTSTARRHDSGVVVSMDAVNEFPGRSAAGGAMPQLKSKFSFDSDDDDDDDGHQAETSRADRVKKPKRRFWRHLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1P3</accession>
    <name>R0J1P3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_36397</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021296.1">
        <property type="nucleotide sequence ID" value="XM_008023105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J1P3"/>
    <dbReference type="STRING" id="671987.R0J1P3"/>
    <dbReference type="GeneID" id="19404130"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000151">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="378"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="486"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="650"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA90900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="703" mass="77490" checksum="C5B291BF9C687B6E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2H6</accession>
    <name>R0J2H6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_25225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021248.1">
        <property type="nucleotide sequence ID" value="XM_008023057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2H6"/>
    <dbReference type="GeneID" id="19402886"/>
    <dbReference type="HOGENOM" id="CLU_849890_0_0_1"/>
    <dbReference type="OrthoDB" id="3693998at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="360" mass="39062" checksum="4B7D1522FE064780" modified="2013-06-26" version="1">MFQRFDITNTNAAPKTTSNPTTVQVLSEKSHYRDDRNSAIATAETRILKQRRIKNPVNAVQIAAPAARVALTGSIVSLLPLGSYTAMFSILAMSIVSRRLQSQAVGCVVAFLHAGGLSGLEGQVLALLSFISFSAVLDSLDGPLHAIYKSSIHDIELVQDTLTAICVSMFFELLVLFSAIFFALHRIFTNAPRFTAASWSRRLSTGTLESCRRFFVQELNYVHGIESFADEESDGFGLGVGLGVTWDAVSQASQEALSTFSSPSSNCGASRGELFKDSEMVEDACDDEARIESRTEDAERRTQALFGDVNRLIDDCNGLDTAQWDEVIAALHEPQGVGVVEDRGPNLDRSLAASAARQMP</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Dhillon B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA81353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0JKE5</accession>
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        </recommendedName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Scott J.A."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the peptidase A1 family.</text>
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    </dbReference>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_008031132.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031177">
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        <property type="project" value="InterPro"/>
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        <location>
            <begin position="2"/>
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            <begin position="929"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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        <source>
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    <evidence type="ECO:0000256" key="9">
        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS52019"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA82373.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2377" mass="259898" checksum="09DFDBC0472E0823" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNL2</accession>
    <name>R0JNL2_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_141071</name>
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    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the rad9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029813.1">
        <property type="nucleotide sequence ID" value="XM_008031622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNL2"/>
    <dbReference type="STRING" id="671987.R0JNL2"/>
    <dbReference type="GeneID" id="19396602"/>
    <dbReference type="eggNOG" id="KOG2810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030657_1_0_1"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="431" mass="47421" checksum="5FA8CD372CA3952A" modified="2013-06-26" version="1">MVVLNFTLTPEAASRVHDLLVCLGKFSDTVAIEARREKLTFTALNPSKSAYAAVTLDGRQFFASYECVPSHGGPDGRFTCSMYTKALLSVFKGRLHDPMGRDGAIDRCEVSVQERENEAQCRFIFKMVCNQGVIKTYKLTYEAVDVMHALFDRSVAKNRWTMHASAVKEYIEYFGTKTEMLDIFAGEDGRCVFKSYTEKISNGKEILKHPLVTAVAVNTSDFEQFTVQAGMHIIINVKDFKAIVIHADTLKTSLKAFYSQPTRPLQFSYGCDGLFCEFTLMTSGNYTAAPPTPAPALAPPTVNSRNSSRAPSAATAGPEGSRSFQSDMPPPVQPASRREGSSRLGSRQTSAQAQSPRHDPESLFVPEDEDAAWAPMDYDKEETLGWDASASHDASAFPTFTDSGSASKANTVESNEVFEPTQRVSQIKGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JRB8</accession>
    <name>R0JRB8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_43369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028882.1">
        <property type="nucleotide sequence ID" value="XM_008030691.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0JRB8"/>
    <dbReference type="GeneID" id="19404848"/>
    <dbReference type="eggNOG" id="KOG1810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001011_1_1_1"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="306"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="704"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="944"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA83643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1653" mass="183058" checksum="7902CE706BA47E8A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0JRT4</accession>
    <name>R0JRT4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Non-repetitive nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_164241</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028311.1">
        <property type="nucleotide sequence ID" value="XM_008030120.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0JRT4"/>
    <dbReference type="GeneID" id="19399053"/>
    <dbReference type="eggNOG" id="KOG1900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000429_0_1_1"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Non-repetitive nucleoporin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-repetitive nucleoporin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoporin_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Putative isomerase YbhE"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="14">
        <location>
            <begin position="97"/>
            <end position="544"/>
        </location>
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    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="13">
        <location>
            <begin position="646"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA83828.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1363" mass="152131" checksum="AF7E82BB191A2132" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">SETTUDRAFT_111921</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA84438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11719" checksum="5010B911C2349707" modified="2013-06-26" version="1" fragment="single">MVGRQPIRHNGQHCPGWKQLRIAWANVGKASECHDTILCRASDENIDVICIQEPWTLPGTVTKNHPGYHMHAPVIAWDSREERENERPRVLTYTRKGVNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0JTQ0</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_166348</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JTQ0"/>
    <dbReference type="STRING" id="671987.R0JTQ0"/>
    <dbReference type="GeneID" id="19399776"/>
    <dbReference type="HOGENOM" id="CLU_176470_0_0_1"/>
    <dbReference type="OrthoDB" id="5424404at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA80919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="93" mass="11007" checksum="373D1E6EAE72B033" modified="2013-06-26" version="1" fragment="single">KRYKADLATKYRLYFELLHNKMKEYNIQPSYIFNIDKKGFLLRILRRSKRIFSKRQYERGGVVSSLQDGSREWITVLACICLDGTPLSPSLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUX4</accession>
    <name>R0JUX4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_163645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027362.1">
        <property type="nucleotide sequence ID" value="XM_008029171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JUX4"/>
    <dbReference type="GeneID" id="19398836"/>
    <dbReference type="eggNOG" id="ENOG502T1VM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076685_0_0_1"/>
    <dbReference type="OrthoDB" id="3914029at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="315" mass="34568" checksum="A35394C8F63A0034" modified="2013-06-26" version="1">MTGWERRRDDTQLGNLRLATWVYLLPSLDLTITTANTPSLTAAIPHLIVSNTSFHLNIYLDIVKEERKKKMSPQKDTDSPPPYAVAYTSSGPVPPSSSSSSQSQTMLNQLSTTRTRHIQSVISHSIIPLIQARTAYGIAQTTLALLPSDIPLPPVAEQSEFSFAAADTDTKPVQVIGFSSQDEPQVVRLQGQMNRTEFWRPQLVIDELETLLTLNLNPPPPPEHTTPTSCDAAAAGESAPRHSRRTLLSRVMPSLGPELRSPGNNPEVGVAQIAQKGVVVVKARLEEICLRTVSEFGLFDTMSRQCVIIRVDARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0JW26</accession>
    <name>R0JW26_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_157592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031082.1">
        <property type="nucleotide sequence ID" value="XM_008032891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JW26"/>
    <dbReference type="STRING" id="671987.R0JW26"/>
    <dbReference type="GeneID" id="19397742"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="184"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="348" mass="39378" checksum="D785276EDEE52F9D" modified="2013-06-26" version="1">MARKYEGVRRVEWNGTQVPVYPMETIDFSALLSQEPDELDKLLQCCKDEGFFYLNLDNVDGRRFLDDHQQLLGLMHRFFDAPLQVKNEYGLVSPHLGYEPVGSRNGVLENTRDGYEMVKISRDEIQRSAPHIPRNLTSASDLKTLEASISGSNIIGKTILCALSTAFGLTGPSRFETLHRNHRPSTSTLALMHYIPSDPAQDQHVGHQKHTDISSLTVLFTEQWGLQIRPPGTREFGFVAPQPRHAIINVGDSLRFASGHVFQSCVHRVVPYEYSEHRYSVAYFLRAEDETMLRDSEGRYVTSRQWHDEKFMAFLAGPADQKAAPKSLLLGGMHEEEGDVYGVCTRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0JW31</accession>
    <name>R0JW31_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_143439</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031086.1">
        <property type="nucleotide sequence ID" value="XM_008032895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JW31"/>
    <dbReference type="STRING" id="671987.R0JW31"/>
    <dbReference type="GeneID" id="19396714"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055356_2_1_1"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA81694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="260" mass="28559" checksum="E55B7EC43E4458F0" modified="2013-06-26" version="1" fragment="single">MTSDPPVVPHPDAQHPDASIDVAHSLSYWNSVTPDVNGMLGGFPQTSRIDLQGSSNFLAKLRRGGKAASKDALPLLGRVADCGAGIGRITRGLLLGVSERVDIVEPVQKFTDELAQSLEQDDDNKTQGALGDIINLGLQDWVPEPASYNLIWNQWCLGHLTDAQLVVYLQRCKQGLVKPTATTEGDAATPRSSWIIVKENLSTDSKHRDIYDDEDSSVTRSDAKFRWLFQKAGLRIVATELQKGMPRELFPVRIYALAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0JWJ3</accession>
    <name>R0JWJ3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_97831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030260.1">
        <property type="nucleotide sequence ID" value="XM_008032069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JWJ3"/>
    <dbReference type="STRING" id="671987.R0JWJ3"/>
    <dbReference type="GeneID" id="19406328"/>
    <dbReference type="eggNOG" id="KOG3208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078034_1_0_1"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA81879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="224" mass="25320" checksum="895FA6C8CF4C4F60" modified="2013-06-26" version="1">MSSTGGGWAQLRQQARTLEQQTETLFHTYSQFGSTPNIPAKPSEEELRVETRLHDILEQREALVAQLSRLLDSESTHGSSAVKQNNLARHREVLSDHRRELARLKSSLNDARNRANLLSNVRSDIDAYRSANQAEADYMLDERNRIENSHNVADSVLSQAYAVQENFAIQRETLANINRRIVGAASQVPGINSLMGRIGSKKRRDGIILASFIAFCFLMLLWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXI8</accession>
    <name>R0JXI8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear architecture-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_44074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030169.1">
        <property type="nucleotide sequence ID" value="XM_008031978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXI8"/>
    <dbReference type="STRING" id="671987.R0JXI8"/>
    <dbReference type="GeneID" id="19404900"/>
    <dbReference type="eggNOG" id="KOG2439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_0_1_1"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="7">
        <location>
            <begin position="131"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA82189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="635" mass="67721" checksum="DD5B66274A1C6A76" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYC1</accession>
    <name>R0JYC1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_28864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026382.1">
        <property type="nucleotide sequence ID" value="XM_008028191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYC1"/>
    <dbReference type="STRING" id="671987.R0JYC1"/>
    <dbReference type="GeneID" id="19403284"/>
    <dbReference type="HOGENOM" id="CLU_1950160_0_0_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="129" mass="13425" checksum="11019EF40D739A71" modified="2013-06-26" version="1">MSDSSWRSVSGKLAARGFLRVARIGIKANRGVGSAIALKPTQRGAKVAAHFLIGISLAAEVIHKTKCLRNGPDVTASEANVENAEEIAKLMDSAVAHFGGLEICCSNAGMHSSGHFTGSSATDFDRNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYC8</accession>
    <name>R0JYC8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_142548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030751.1">
        <property type="nucleotide sequence ID" value="XM_008032560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYC8"/>
    <dbReference type="STRING" id="671987.R0JYC8"/>
    <dbReference type="GeneID" id="19396674"/>
    <dbReference type="eggNOG" id="KOG4254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Han J."/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA83199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="276" mass="31402" checksum="ADA15A4EB56A0E10" modified="2013-06-26" version="1">MIRGSIEEQALLRAPIDVGARTTRKSSCRMLYVFLLLMTNICSGILAFHSGRLDARRVYSMDPIGIEAVYKGVSRHLVDHRFSQFDLYDNRSRYTATPSKAVDDAWDEIGAGNHSFLLPLQYGSLFGLDQRRNLHVRPPQWGPDKSGYLVQLWASHDVHCVNLLRQSLYFNHDYYKSHNGHLNETEAEHRAHINHCVNILRERVMCVADARVIPMGWGPGEFDFGVSRRCHLHRPLIDWLREHDIGPNDPGVAWDLIKIPPDAIPGAAGYTLPTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0K150</accession>
    <name>R0K150_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_23367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030052.1">
        <property type="nucleotide sequence ID" value="XM_008031861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K150"/>
    <dbReference type="STRING" id="671987.R0K150"/>
    <dbReference type="GeneID" id="19402657"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1422230_0_0_1"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20126" checksum="7708A472D940E744" modified="2013-06-26" version="1">MSSAAAPASPAVVRSSSTSRRSGERPNRSQPAASRPAAPAQAPAPALAPARHHQPPPPPPPQQQPALANVTRRDYDQPSVAHDPPVRRSEEPPRPDSSRRTHSRYASDASTTSAMPINGVAVDARTVQQQPVNKRRTTITAPATGTWALGKTIGAGSMGKVKLAKNVETEEQRLHSLAPVDAPGIPRVPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1S7</accession>
    <name>R0K1S7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_120673</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029549.1">
        <property type="nucleotide sequence ID" value="XM_008031358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1S7"/>
    <dbReference type="STRING" id="671987.R0K1S7"/>
    <dbReference type="GeneID" id="19395822"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="11"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA82392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="243" mass="27319" checksum="102247ADC0D845E4" modified="2013-06-26" version="1">MAPEQSKNKYSVLLPTYNERRNLPIITWLLNKTFTENNLDWELIIVDDGSPDGTQEVAAQLQKVYTPERIQIRARAGKLGLGTAYVHGLQFATGNFVIIMDADFSHHPKFIAPMIALQKTKNYDIVTGTRYAGNGGVYGWDLKRKFVSRGANLFADTVLRPGVSDLTGSFRLYKKEILQKVIRSTESKGYTFQMEMMVRAKAMGCTVGEVPISFVDRLYGESKLGGDEIVEYAKGVFSLWMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0K200</accession>
    <name>R0K200_EXST2</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_22331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028764.1">
        <property type="nucleotide sequence ID" value="XM_008030573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K200"/>
    <dbReference type="GeneID" id="19402534"/>
    <dbReference type="HOGENOM" id="CLU_2533798_0_0_1"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA83634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="84" mass="9368" checksum="6292C997AE5096D0" modified="2013-06-26" version="1" fragment="single">MNPSERTKEALLAKTEALCTSIVDNRKDDPWGGDGYLSTILRTVKMHEATDYSSVHNKTEFEPALDFSTSAHKELLIKEQTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K244</accession>
    <name>R0K244_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_164139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028205.1">
        <property type="nucleotide sequence ID" value="XM_008030014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K244"/>
    <dbReference type="STRING" id="671987.R0K244"/>
    <dbReference type="GeneID" id="19399008"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="46"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA83679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="468" mass="50138" checksum="FA0EA1A29FD1E8CB" modified="2013-06-26" version="1">MGRSNDKMGDDIEYGNPLKAEDTNPQGQADAVFGEVVEGGPNYRSVNWWASSIIMMKTQIGLGVLSIPAAFDALGLIPGIISLLAIGLITLWSGYMVGTFKMRHPETYGIEDVGQKLFGRAGREVLGLAFALLWTCVAGSGMLGISIGLNSLSEHGTCTAVFVAVACFVGFALASIKTLGKLSWIAWVGLGGIMSAIITLTVAVSIQDRPSAAPQFGPWQSDFELFKSPTFAEAAAALSSIVFAFCGIPAYFNVVSEMKDHKDYFKALSLCQFVMTSIYIAIGVVVYYYCGSYVASPALGSAGVLMKKVCYGLALPGLLASVILVTQLVAKYFFIRTLRGTKHLSHPTAKHWITWFGFTAAVSLSAYIIASAIPVFGGLVSLVGALLGTLMSFQPMGCMWLYDNWHRSNRDWRWKGMVAWSIFVIVAGTFLLIGGTYGSIVGIIDSYNKNGGTKPWTCADNSNSSGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0K420</accession>
    <name>R0K420_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_155675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>R0K6C2</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="215" mass="23765" checksum="0DCB54A9451633A6" modified="2013-06-26" version="1">MPKVPSSRRVRSENSTQQRQSRADRIRQQGNEMTFRCKRCEEKNLYCFVDTATGRCASCIAIKAECSLFVTKEEWEKVEANKRSKRLALLRAKAEVARLRLEVAETKALERSYADHDHAILSLQDRAKEQAEGDSAPGTSLPAVEPSLPGPSADLGGLQADYSFDPFSLDYFLSLEEPVLASSDASDGILVPVTRCSSSFLQVPKCYGSRAIPST</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <strain evidence="9">28A</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3R)-atrochrysone 2-carbonyl-[ACP] + H2O = (3R)-atrochrysone 2-carboxylate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64236"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:20479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:234107"/>
            <dbReference type="ChEBI" id="CHEBI:234110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:64237"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023472.1">
        <property type="nucleotide sequence ID" value="XM_008025281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K733"/>
    <dbReference type="STRING" id="671987.R0K733"/>
    <dbReference type="GeneID" id="19400408"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_1_3_1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF3">
        <property type="entry name" value="ATROCHRYSONE CARBOXYL ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="65"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="336" mass="37515" checksum="C85CED6FB3391E84" modified="2013-06-26" version="1">MSTDQVSTEDKGGYRQINKALNICAFEDYLKGQTANLEQIPDVEQVTERVLRVRGQNPGKFTFQGTNTFLVGTGASRILIDTSGGEPEYAKLLASTLESRNISIKYVLVTHWHGDHSGGVPDLIRMYPHLKEHIYKNDPELGQKDIYDGQQFCVEGATVEAVHCPGHSEDHMCFILKEENSMFTGDNILGTGTSAVEDLGIFMSSLHKMMDQKCRAGHPAHGITIDDLNTKISRELSSKYRREKQVIRALKNLRDYGQNRPVVRDIVNNIYGSSVDETTRTLALEPFIDEVLRKLAGDGKVGFQACRGQRKWFLIASEQNSTPMPHLQSSVTRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7G3</accession>
    <name>R0K7G3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SETTUDRAFT_91593</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027846.1">
        <property type="nucleotide sequence ID" value="XM_008029655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K7G3"/>
    <dbReference type="STRING" id="671987.R0K7G3"/>
    <dbReference type="GeneID" id="19405914"/>
    <dbReference type="eggNOG" id="KOG0539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="354"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <ligand>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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    </evidence>
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    </evidence>
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    <sequence length="157" mass="17025" checksum="8E150DD3DE9B07D8" modified="2013-06-26" version="1">MFASTLRAAARAPQPTAAFARSFSSSRPSQIARMTIVGRLGVVPEEVTVSGERTLVRYVVGTSHGKGEEKKTSWFRVASFVQGAQKDFLMSVPKGSMLYVDADARMETYFDADGAKKTNLSLVARNFEVLTRARTEEPDPNDEGLVQEASEASEASG</sequence>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8X8</accession>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023206.1">
        <property type="nucleotide sequence ID" value="XM_008025015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K8X8"/>
    <dbReference type="STRING" id="671987.R0K8X8"/>
    <dbReference type="GeneID" id="19400343"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024877_4_0_1"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA89428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="292" mass="33060" checksum="21B4E6EAB3E12619" modified="2013-06-26" version="1">MTAPFDNFAEFSMFATLHDGTIYIEEDFPSRAAQRAAEASRPPPRHQHPDQQSREMMTYWGYKFEKLALIPTLPSETPPHEIERHQRGIVSNHAQHCSIVHTSFGPHSLILGGEVDGLLAPKSTHPDQPPQWVELKTSEELPPPHLQQHRDILKFERKLLKFWAQSFLLGVRKITVGFRSKSGILRSLQTFNTHDIPGMVRRGTGCWDGNVCINFATEFLAWLKHVVRDEGVYSVNLRKKSGVIEVKKVRDGVDKIVSDEYRKWRAEQESVDEVDKATGGGSIDKTEGKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9C6</accession>
    <name>R0K9C6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_32121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027004.1">
        <property type="nucleotide sequence ID" value="XM_008028813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9C6"/>
    <dbReference type="GeneID" id="19403626"/>
    <dbReference type="HOGENOM" id="CLU_1294175_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354028" evidence="3">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA84882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="254" mass="28032" checksum="7931B2F1ED07B10C" modified="2013-06-26" version="1">MVSTLLALCLFACHAIALVSAHNTTVTSTSMLTIPIFTLVVVNPSSPPLSPPPPPTNTTTSLLPPSHDLQPSASETSVSTTPRSLTRTPSLVTLASPVHATLPHTPLPPPNSMTTTTTTTTTTTTTTTTTTTTTTTTPSTNFAAQISSTPWIVPVTATLLCYDFLLALALAWCWAMGWFWWWRNPSHRNSTRRERRAVLAWDEDEEMGDGGVEWEDQEEARRRRRRRRRRHVALTRVMLVDGGIEGEMRRLGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0K9L6</accession>
    <name>R0K9L6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_171954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="3"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027461.1">
        <property type="nucleotide sequence ID" value="XM_008029270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9L6"/>
    <dbReference type="STRING" id="671987.R0K9L6"/>
    <dbReference type="GeneID" id="19401146"/>
    <dbReference type="eggNOG" id="ENOG502QQFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031603_2_0_1"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000299">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF40">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="2"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="445" mass="50741" checksum="996160CB283C6487" modified="2013-06-26" version="1">MYYLTGMNYWACMNLAASDSVGGNYARLVTELDQMAERGINHLRIMASSEGAPTPQPFRMTPALQQAPGEYNEEIFKGLDICLAEMSKRGMRATMTLNNEWQWSGGFAQYVSWATNNTKIPYPPSWNLTAPPQRETPGTGWGNYTVQGVDAASYNEFTAYANLIYNNTQAEQWYKDHIKTVMSRRNTVTGRLYTEDPTIMTWQLANEPQPSDQVGFTGPYNIFLKPNPDDLLFPWVDRISRYIHSMSARQLISVGLESKQGEYYFKRVHNFSTVSYATTHCWVQNWGVYDMYNASEANLAASQKFASDFVKNSSAWATDIGKPVFLEEFGMARDNWENKDKEYPYLSSASTTHKDQYFDTIIGAVMQDFMNHGPYIGTCPWAYGGIYRPETQHADEFGMVWAGDPPHESPGWYDLYDDDIAMDIVEKQHRVIEAWIAENGDDDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0KB15</accession>
    <name>R0KB15_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_153393</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025239.1">
        <property type="nucleotide sequence ID" value="XM_008027048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KB15"/>
    <dbReference type="STRING" id="671987.R0KB15"/>
    <dbReference type="GeneID" id="19397294"/>
    <dbReference type="eggNOG" id="KOG0056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_6_1_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044604">
        <property type="term" value="F:ABC-type phytochelatin transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036249">
        <property type="term" value="P:cadmium ion import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071996">
        <property type="term" value="P:glutathione transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036246">
        <property type="term" value="P:phytochelatin 2 import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000050">
        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="336"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="654"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="903"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA86579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="107027" checksum="400BA82981DA0B45" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KB35</accession>
    <name>R0KB35_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_87693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025248.1">
        <property type="nucleotide sequence ID" value="XM_008027057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KB35"/>
    <dbReference type="STRING" id="671987.R0KB35"/>
    <dbReference type="GeneID" id="19405661"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="137"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="389"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="432"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="530"/>
            <end position="532"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="634" mass="72340" checksum="1E3CE9501B8BA858" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBC0</accession>
    <name>R0KBC0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_162872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025293.1">
        <property type="nucleotide sequence ID" value="XM_008027102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBC0"/>
    <dbReference type="STRING" id="671987.R0KBC0"/>
    <dbReference type="GeneID" id="19398569"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_0_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA86664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="250" mass="27981" checksum="F40C61D68B1B2707" modified="2013-06-26" version="1">MNAHFHQVNVTDYASLSRAFEAAYNASQRLDFVFANAGVVEKDNFYAQHDVQGPPPPPPNQLSVDINYKAVVDTSYLALHYFRKAKSRRENSELDPVLVMTASCGALYPSEFCPMYSGSKAAVMHFNRAIAVAYHHEGIRTLSICPGMIRTGLMTQEEWSFFQPEQFTPVESVRDTVVKLVDGGDLKDAKGVSKSRSEMWGLTVEINGQNFYFREAPEFCDDNMRTMMAHTSMTTQLARIEAAQKGASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCE6</accession>
    <name>R0KCE6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_161967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908488">
        <property type="protein sequence ID" value="EOA90568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021802.1">
        <property type="nucleotide sequence ID" value="XM_008023611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCE6"/>
    <dbReference type="GeneID" id="19398231"/>
    <dbReference type="eggNOG" id="ENOG502TFCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131085_2_0_1"/>
    <dbReference type="OrthoDB" id="5418749at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11220" checksum="3B95147A374023BD" modified="2013-06-26" version="1">MAAPESYVQKLQHYCATNQIAQPQFQDYSDPRGIRTAWSSSVFVHGREYRAALWRDYRYLEQSREEAAEVAWKAIHSTPTTNGANQGQYNRSYATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCT3</accession>
    <name>R0KCT3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_31455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025067.1">
        <property type="nucleotide sequence ID" value="XM_008026876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCT3"/>
    <dbReference type="STRING" id="671987.R0KCT3"/>
    <dbReference type="GeneID" id="19403550"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="29"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="354" mass="38360" checksum="29746172245A4FB3" modified="2013-06-26" version="1">MSQIRTASVDTDSIPATMRAWQWLACTTTLEESIHMNESAPLPTENRPLSSGESLIQVYAAALNQVDYKLAELPVVGRMAIPKPATPGLDFAGKVMRVGPDCNVSVGQMVFGKLEPRQQFGTLGEYIIGSNAGTVPIPQGVTTDEAATLGVCGLVTYQCIAPNVKSGDRVLINGGSGGTGTFAIQIAKALGCQVTTTCSDANIQFCKDLGADEVIDYRKNDILSTLANGSQQYDLILDNIGHSFELYWKSPWFTRPGAKYVQVGSQVSLPFIYDLAFRFLVPTWLGGGQRPFSFGFALTNFKDFTALAKLVADGKVVPAIDDVYEFEQVPKAYKKLRTGRAKGKIVVRLRRDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KD61</accession>
    <name>R0KD61_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_110644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026365.1">
        <property type="nucleotide sequence ID" value="XM_008028174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KD61"/>
    <dbReference type="GeneID" id="19395431"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="530" mass="56456" checksum="C85E304A399B9DB1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>R0KD65</accession>
    <name>R0KD65_EXST2</name>
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        <recommendedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_161587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028177.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0KD65"/>
    <dbReference type="GeneID" id="19398171"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_4_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA88759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="326" mass="37641" checksum="438516850E665480" modified="2013-06-26" version="1">MLKQAKPKTARAKREMKKREPQQHENPKTTLFVSGQKTSQILKLAVADLCTLKRPMAERFTKKNDIHPFEDASSLEFFSQKNDTSLLVLSLHSKKRPHCITLARTFSYKMLDMIELYLNPETFRTLQQFKNKKPSIGLKPMLSFHGTVFEDPNQTKYTLFKSLFIDFFKGHDTNEIDVEGLQYIVSVAAEEPTDELPNPQVHLRFYLLRTKRSGQKLPRIEVEEMGPRMDFTLGREMFPDPDMLKQALKTPKGNEARTKKNIDMNSMGDKTAKVHVGKQDFGNLQTRKMKGLKRGRNESDDDEEVGVEDSESEDEEEEKTPKKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KI27</accession>
    <name>R0KI27_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_168824</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the BOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024576.1">
        <property type="nucleotide sequence ID" value="XM_008026385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KI27"/>
    <dbReference type="STRING" id="671987.R0KI27"/>
    <dbReference type="GeneID" id="19400679"/>
    <dbReference type="eggNOG" id="KOG3251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078260_1_0_1"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA87672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="252" mass="28800" checksum="B2BA921E4896D32F" modified="2013-06-26" version="1">MNALFNSALRQSTSIRKDLDQFADSAAPSPHLQAQLNASLTTFARTIDDYGKLARQEPVQTKAEKAQERLKTFRAELDEYRASFKRIKSANEDIQTIQARTELLGRRPHNTATPENPYAQSNLAAQHSAFAPSQPYDPNAPYRPNPYSAGAPQGGEYDREGRVLRENTFFNKTSDQLDEFLDRGRAVLGDLHQQRDMLKGTQRRLYTVANTLGISGDTIRMVERRAKQDKWIFWGGVVFFFLFCWLVIHFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJN4</accession>
    <name>R0KJN4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_37907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022928.1">
        <property type="nucleotide sequence ID" value="XM_008024737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJN4"/>
    <dbReference type="STRING" id="671987.R0KJN4"/>
    <dbReference type="GeneID" id="19404305"/>
    <dbReference type="eggNOG" id="ENOG502SEUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106353_1_1_1"/>
    <dbReference type="OrthoDB" id="3990500at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354237" evidence="2">
        <location>
            <begin position="27"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="170" mass="18653" checksum="654E0DED7099513C" modified="2013-06-26" version="1">MSFLLPGLRRGLLLSTPLILSTPLLAYQLRNGQRIRCDGPDPLTKITNDLKSNYTTEAKTPVITQSGVMNPETVQQISMGSILGVIGGIGLSVFSRPLAILIGLGIFAVQTIRSMLRKGKFIESRGIHIIPYAFLQRRIKSVNIQSLVRDNVAFKLSFGLTFAMAAFSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLB0</accession>
    <name>R0KLB0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_106576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023432.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLB0"/>
    <dbReference type="STRING" id="671987.R0KLB0"/>
    <dbReference type="GeneID" id="19395179"/>
    <dbReference type="eggNOG" id="ENOG502SJG1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5331891at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="351"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="607" mass="67854" checksum="A84C661CB78F363B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLE8</accession>
    <name>R0KLE8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_103861</name>
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    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19395012"/>
    <dbReference type="HOGENOM" id="CLU_729558_0_0_1"/>
    <dbReference type="OrthoDB" id="5420711at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="381" mass="44487" checksum="18B084A163046C17" modified="2013-06-26" version="1">MNSRLLATPREIRDLIYEYALVRGFILVERAAATVPEADAKRCPEFYSQLARSYPLTRTRNHRRVWSVPRFDIGMPSFKGDPEDPPSHVRMTYQLARPCNLPFQDRIEINLLQTCQQIYHEARKVFYSKNVFGFKTTECVPTAFAFLCDRPADSLRLISSMELTLGEGTNLRGTAEAHYPVVPRSTDSLVLRYAYNHFTDLCTLLSTSRMRLRKLSLIIDGLHQFYRPVIPSPADSMLWEAQRMASPRPWVASWIHPLLKLDNPECLEVHWILDRPEICRMADTLSLMRRQMLVRTGYEQHGYSDILRKPKFDFRVSFRIHYQVVTQERTSICCELSRNDLLLCDDEDDDGRTKKLHSSEERLTKAWRRHIRNIFKASGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNM2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_148052</name>
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    <organism evidence="2 3">
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        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023269.1">
        <property type="nucleotide sequence ID" value="XM_008025078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNM2"/>
    <dbReference type="GeneID" id="19396950"/>
    <dbReference type="eggNOG" id="ENOG502RH73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_693647_0_0_1"/>
    <dbReference type="OrthoDB" id="3753493at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="391" mass="44304" checksum="A4C2AB313FCDF935" modified="2013-06-26" version="1">MAEEEQRGKGTARRRPSTRRDFDPIPLPVPKDVATLQERRLMSGKPKRPARWRGPQNNAGALSTTWPKHTAPAVQSHRATRSIRADTPTSESHPPKSQNVELRFSFSATPDESPSPRGREETVTRSFSGLCMTGSANRSVSANPPQTRASSAQEPRRHSESIPQAPQLEKPKKKREGYGFSYSETFMFDSDDYPDTECEWEPDEPPSHPKADSPADANPYLNWDRTEQISRPASRDSTATVEDQSFNDLVVLRDVGSFHLARPQRILPCTPATREDTLRLKVQAKTLVSKYEESADIQAQLLTRLERMMYLQQQQQRRASTPSDTNAMATCAEKLRDFLLRVKEERVETGEHSTIVEHELEWVTWLVQASKTGVMHVRTEGCTCRPDWDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPX5</accession>
    <name>R0KPX5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_36555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="entry name" value="HET"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="57"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="505" mass="56491" checksum="BFB2C94B46A276EF" modified="2013-06-26" version="1">MVPPLVSYTKITDWMNQTYDHSEPRADPVLRSRTAVPLTVIECTTRSLIILPENEAYVTVSYVWGSVTFDQTTTQSGKYEPNSLPLQLPSTIEDSITACLALNFRYLWVDRYCIHGSHDVCAQQIKHMDKIYSESALTIIACAGADSSYGLPGVSRPRKPDPSIEIKGLGYLRAIPAMYDIESSVWATRGWTYQEALLSKRQLYFTEKQLFLGLYDKIESEAVVHGGDWVSGAISDVARSKHSLGMSNVYDCIGEYSERQLSYPEDILNALLGILSKFHETRGVFHVWGVPFKGSNSNPPEGSTQSNELVFEESLCWSANKQTPRKGFPTWSWTSRDGVVRWPIMFPLTLVSAPSNAGAAPKFEVELRSGQLCSLSEYQVRYDHLNNYSEAVLSQDRPSQFIHVEAFVSPIVKIQDMVISDRVVLRSSTGEPIFLEVVGSERLAPGLPGSLVAVHLVTGSYAHVRTKYALIVRDMGDHWERAVLIEDIECLLEGAVKVRRKLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPZ2</accession>
    <name>R0KPZ2_EXST2</name>
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        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_125556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021736.1">
        <property type="nucleotide sequence ID" value="XM_008023545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPZ2"/>
    <dbReference type="STRING" id="671987.R0KPZ2"/>
    <dbReference type="GeneID" id="19395974"/>
    <dbReference type="eggNOG" id="ENOG502S6VI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063513_2_1_1"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="203" mass="22570" checksum="4F166E8FE2C35767" modified="2013-06-26" version="1">MADVLCGVCATEPKKYKCPTCALPYCSLICFKTHKATHPENITTPAPTPAEPTLPQPAPPAPIPRYLKSRTDFSVLATNPKFQALLKTHPTLLSSLQRVYAKTIQPDPEDERRRRLLERNAFRGRGARGRGRGRGRGGRGGWHGEDREERWTPKKGDKDAMAVLKEIRDGETQDDEKEAMAQFVGLVDELFAQKDKTSGVEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_103728</name>
    </gene>
    <organism evidence="9 10">
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Exserohilum</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030653.1">
        <property type="nucleotide sequence ID" value="XM_008032462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I744"/>
    <dbReference type="GeneID" id="19403980"/>
    <dbReference type="eggNOG" id="ENOG502R87G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171283_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="113" mass="11842" checksum="BABAE2273D6B14E9" modified="2013-06-26" version="1">MSSPYTSPYTPKAPTYPSRPSTASTSKPLLFPPPLPTKSLTKHHQPTGYSTSSTSSQSLYTNSPTSAMSPPSSSSSSSSRSKKYSKPPVIHNGGGKLNDPNTSTSAPNGGYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0I7G2</accession>
    <name>R0I7G2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_165892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030884.1">
        <property type="nucleotide sequence ID" value="XM_008032693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I7G2"/>
    <dbReference type="MEROPS" id="S28.004"/>
    <dbReference type="GeneID" id="19399623"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023630_0_0_1"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA81406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="358" mass="39406" checksum="1CC257630ED9B1A5" modified="2013-06-26" version="1">MYGGSLAGAQTAFTMKTYNDLFAGGIGSSATVQAHLGYPSWYTPIMKFGPSDCVSRVISIVDKMDALIASGNEKGIQQLKDIFGLGSLSSLGDFAMTIAFPIGGPMNYPTNTWQELNWSPLYGSSDFFDFCSNVTNPSSPGNTSSVDTALAQYSDGEAWTGLSNYAAYIKRVLLPECTTGRINSTDPGCFSTQNQTFYADPTNGASRSYLYSTCTESGAYQVAPAHGPSLISRVLQIPYTQQWCTWAFPPGQYNSIPPTPALHYYNSYGGWNIQAKNLALIDGNTDVWLDLCYHSNLVDKLRISSDLHPSYLIAGAGHHWDSYGIKHVLAEPQFIREAHLWEERTVARFLERWAQKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8M6</accession>
    <name>R0I8M6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UMP1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_97178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030257.1">
        <property type="nucleotide sequence ID" value="XM_008032066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8M6"/>
    <dbReference type="STRING" id="671987.R0I8M6"/>
    <dbReference type="GeneID" id="19406288"/>
    <dbReference type="eggNOG" id="KOG3061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_1_0_1"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA81875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="50685" checksum="3556689C072AFA3B" modified="2013-06-26" version="1">MKPIIAIPAIAALVYRAYSRKSLTPVGIAAAFGTAVVHALHPWSVCFALLAVFFLAGTAVKHDVKAKLTQSATGASGGEGARNHVQVFANSGIASVLILIHLWQLKNEGRYEDENLCWSGRNDVVVIGIVANYAAVAADTFSSELGILSKSKPRLITAPWRVVPPGTNGGVTATGLGAGLLGAFILSLTSTLLLPFCQDWTFADKATYTLALTAAGFSGTLLDSLLGALLQASVVDVHSGKIVEGEGGRKVIVHSSHALHLSKAGQNATGTTSGADVAASVKGSEMMLKAGASGTAVADKQHESRKVEVGSDLLDNNAVNILMAGLSLRFVPSKAHPAQTSLETSAPSAPGVHDTLRSRLGQTCAAPTAASSSTAPVALQSAHPLEARLVQWRDTQDRLKMEMLRRQFGIAEPVRRGMELKIAEAGEWRPLALGGSSGVHKDILQGRDCEIGWEDVFTGNELRQVPDFHTEMEHKMKMNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9R3</accession>
    <name>R0I9R3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II beta 2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_122269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030407.1">
        <property type="nucleotide sequence ID" value="XM_008032216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I9R3"/>
    <dbReference type="STRING" id="671987.R0I9R3"/>
    <dbReference type="GeneID" id="19395878"/>
    <dbReference type="eggNOG" id="ENOG502S2SB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035164_0_0_1"/>
    <dbReference type="OrthoDB" id="5415241at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038816">
        <property type="entry name" value="Stationary_phase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342:SF1">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="48692" checksum="2E6444539621FCB4" modified="2013-06-26" version="1">MMAPAAVHLHRLVVKNAKAFKAAWKHAAKLVQKQLPESARPADAVLQPILARNAPKHPLHRIAYLKQSKGRWYTTHSQISAAVRRFTTSAARNSGVKYDKASFPKSRIGSIVNSQAGRAPFASTLRPNLTGGTLGRTAGGYGWGSGRTGGARYFSHGPAAPAQVINNVSQAVRAFLLGGQKAQFDGVNPHNGEKRFKAVSALQDQVNRTLNKVPTASAGSSISFNINPTVTALTPLKAVKGFASFAQEKETLNSEGLLKNLSVDFSRAVLELAAVLKDLQRLAALGDLPISYEDSTLKVHFPGCDAQTVESICNDFGITRGVVHEDENFDSSVGTDIALMFPFAPSKTPSECSFYAKPVTDRQYVQPDIDWTNMLSPSATESEGFATPSEHSYDQLDDFITEPNPWLSVSSPSGYESLHTSEADEMDMETPMNFQATQGLHIFTGPCEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0IA11</accession>
    <name>R0IA11_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_34889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030124.1">
        <property type="nucleotide sequence ID" value="XM_008031933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IA11"/>
    <dbReference type="STRING" id="671987.R0IA11"/>
    <dbReference type="GeneID" id="19403958"/>
    <dbReference type="eggNOG" id="ENOG502SHS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="341" mass="37803" checksum="E0E39B0AF3569087" modified="2013-06-26" version="1">MPKKLITILGATGTQGGSVANRFLSHAEWRVRGLTRNPGSAKAKEWSRRGVEMVKGDYDDLESLKAAFQGANAIFAVTDWATCFTRVSEDKTLQDEAEAAGMSFEEYAGDLETLQAINVATAASDPKVLSTLDKFIFSTLAPVQRISGGKYKHAYEFDSKAAAERYMRERLPDLRSRLSTVTMGIFQETWRDIAAFRPHKLPNGTFEYVRLRTSGRHQANPEVVATRDTGVFVEALVLHHPPGTDVLGASEILTKPEYAATWGRTLGVEAKVRDVDEDEYVKYLPEGFEATVIDDVRFFAEYGYAGGNPKVKTPAELGIKTTALEDFFRDEDWSAVLKGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0IAB7</accession>
    <name>R0IAB7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_156190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IAB7"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009811_0_0_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004342291" description="Zn(2)-C6 fungal-type domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="547"/>
        </location>
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        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA83140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="547" mass="60980" checksum="D0B83FD1BE66B987" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>R0IDK0_EXST2</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_94396</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EOA83430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="358" mass="39296" checksum="9D96366B2533B1B9" modified="2013-06-26" version="1">METPGQLSQLRILQRQYFQLVEPQQLRWPDEAILKRPQVQTWLFTHLLDASTISSPPPVGYQLRFLKELVARLERSITDPEEDEISDDIMEAMTRLLTTNLPSETSAAQQKALVTYSFPQQPTGASVSGERTVTLLEARSVISSSGTTGLRTWEAALLLGSYLASAGGRGYVNQKRLFELGAGTGMLSILCAKHLGVAGVVATDGDEAVVDAIKTNLFLNGLDVNDDSGCQVRTAALKWGYPVNATSFAEDYGMDVPDTVLGADVTYDSAVIPRLVSTLRALFALNRRLRALVSATIRNEQTFETFLDACKRNRFSLEPIDCPLVPEDDQEGPFYPTSTPIQMWCITRGQAADDPFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0IDM4</accession>
    <name>R0IDM4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_95138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008030818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IDM4"/>
    <dbReference type="STRING" id="671987.R0IDM4"/>
    <dbReference type="GeneID" id="19406144"/>
    <dbReference type="eggNOG" id="KOG1812">
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    <dbReference type="OrthoDB" id="10009520at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="337"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028047.1">
        <property type="nucleotide sequence ID" value="XM_008029856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGD9"/>
    <dbReference type="STRING" id="671987.R0IGD9"/>
    <dbReference type="GeneID" id="19402465"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1603764_0_0_1"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="17956" checksum="D2EDF115888FBB21" modified="2013-06-26" version="1">MTKNAPRALGDLHLKKPRVNRLAGHDLSDLAGVETGLAPGRSAKHDLVSNKAHFAVRTLKGQSLVLLASDGVGGTNEAEDATRLAVDWWQQGNDAKEIADKLTQREGKSKGADNCTVLVVVLDTESKGRRSVDSGRRSFDVSSDGSGSRRRRRSSIASLKDWIRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHK4</accession>
    <name>R0IHK4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_47960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KB908704">
        <property type="protein sequence ID" value="EOA84466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027889.1">
        <property type="nucleotide sequence ID" value="XM_008029698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHK4"/>
    <dbReference type="STRING" id="671987.R0IHK4"/>
    <dbReference type="GeneID" id="19405165"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022549_0_0_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF43">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA84466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="470" mass="53316" checksum="FDE5C8BB9F3C0A74" modified="2013-06-26" version="1">MLRAIAGRLTRRPWRFVFPGILFFLFFYSLSHRTGSRSQGPARKAKTKSFFPPLETKAANSIELDYCKNFPTKLLEEVQVVLKVASDGAHETKAHLNTVSSCITNLIIVGDREERLGDRQVIDILAELPKSYQKDNLDFQVYVDQKKAHEGGETVKGQQRSFKLDRFKYLPMVDKAYISNPTAKWFVFVESDVYFFWDTLFRLLSQLDPSEPHYMGEPHKGSEGRQFAYGGAGIVLSQGLVKKLIPGKTAGSTEIPRENRLAVRYESWVKEEQRGDAVLAYAIQNATGHKLANMHPTFASDKVKDVTTTKERWCVPMLSLHQVKPQQMEDLWKWERTRPYNNHPFTYSSFLSYTHSFLSQGPSREWWDNLSTAPVPNDRPAHHNAGSCGSECAADNNCLQWSYSQTVCRHADYIKLGDAVDRENGGQGEFVSGWDTAKLRTMGFGVEAENGQREFYAGCVEATWITPQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHP7</accession>
    <name>R0IHP7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_154344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027260.1">
        <property type="nucleotide sequence ID" value="XM_008029069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHP7"/>
    <dbReference type="STRING" id="671987.R0IHP7"/>
    <dbReference type="GeneID" id="19397398"/>
    <dbReference type="eggNOG" id="ENOG502SI6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043687_0_2_1"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
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    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="KB908659">
        <property type="protein sequence ID" value="EOA85671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026746.1">
        <property type="nucleotide sequence ID" value="XM_008028555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILK0"/>
    <dbReference type="STRING" id="671987.R0ILK0"/>
    <dbReference type="GeneID" id="19395495"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA85671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="322" mass="37007" checksum="509F682466940FBA" modified="2013-06-26" version="1">MAENEVDLDSIIDRLLEVRGSRPGKQVQLLETEIRYLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFVLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDCGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAEKKQKYVPNLGSSRHGSRTKPSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IM20</accession>
    <name>R0IM20_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_161557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026345.1">
        <property type="nucleotide sequence ID" value="XM_008028154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IM20"/>
    <dbReference type="STRING" id="671987.R0IM20"/>
    <dbReference type="GeneID" id="19398164"/>
    <dbReference type="eggNOG" id="KOG3999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035754_0_0_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA86070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="337" mass="36489" checksum="86E01B16C2E39635" modified="2013-06-26" version="1">MRFKASIQNITTFTKLTASLNSLGPLAWVKLSEEQVCFTIIPEQGTQDSIFETISVQSAANNVINLEVPLTSLNRALKSALNATSAHIRLTKKDNVPMLALTIVTTTSSNTYSAFPAAAGNNQDGFDAPFDSDFGTGNRETIVTQEIPVRVLAPDTVAHLHEPACREPDVHIILPPLMQLKSISDRFTKLALADTKVNSSTTTTSSARTRLEIAANMHGCLKLSIRSDAMSISSVWTDLNNPELDPGHVAGGEDGIAEHPSTRMKQLGSADGRSDEGWAVVRIDGRDWGKVMSVGRLGGRVIACFCHEHALILYVYLPNDNGEDESVLTYFISSYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0INT0</accession>
    <name>R0INT0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 93 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_88794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Han J."/>
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        </source>
    </evidence>
    <sequence length="360" mass="38313" checksum="6CC6F2F4154B7FF0" modified="2013-06-26" version="1">MPSAIVIKQVPGKPDQVYYPLEKITVPEPKPADNEAVITLTAAALNHRDLFIRQHLYPGTAFGVPLLADGVGVVTSAGSSPAAQAWLNKRVVLNPGTGWKNDPEGPEHPKGYAIMGGTKSNPRGTLQDVCAIDVAELEECPEHLSDEEAAALPLTGLTAWRAFQVKSGNAVAGRNILITGIGGGVALMALSFAVARGCNVYVTSGNQDKIDRAVKLGAKGGVIYKEKGWDKKIKALLPKDRPYLDAIIDGAGGHVIAAGTKLLKNGGVISVYGMTVSPKMDFLMSAVLRNIEVRGSTMGSRKEFAEMIQFVRDTKMRPVVSRSVHGMDLAKIETLFDDMKNATQFGKLVITLGSAKASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0IUW7</accession>
    <name>R0IUW7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_149248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023957.1">
        <property type="nucleotide sequence ID" value="XM_008025766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IUW7"/>
    <dbReference type="STRING" id="671987.R0IUW7"/>
    <dbReference type="GeneID" id="19397011"/>
    <dbReference type="eggNOG" id="ENOG502S7PV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029042_1_0_1"/>
    <dbReference type="OrthoDB" id="4205424at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="2">
        <location>
            <begin position="272"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="449" mass="48680" checksum="8957B5FF9AFB3746" modified="2013-06-26" version="1">MPLYLAAGPSLDVWTTEESTQAWFESLLLSNPATLSDTPGQTANEWWKLARSQSPIGILAQVQDVAEDAQKPRVTEILFYGTIAIHAIGGLPTPPLSSSSIENISGEQLPELRVHATPLSSDLLHRSSISLPLDDDAHFLPPLHNAHGPPKSPKKHRDIFEEATIANKKARGSGGRAVSAAAARGSESQQPYTHRKSSLSIDKRASPFTDSRPQSASGALPHPSSRPHSRSPSISSDTRPLSRKGQPEAHARRSNLSQVATIPIQPEEPTTESRNKDALVKVVMAAMRMHGLQQRKPNKSRRASLAVGGEESERLSEEAIAEAAKDDEYKLIYHQTYKGAALALRKHMSEKPLHVQPDRMRDVVEKLLTIFLSDPLAEPPPADVPANPVATPGSKSRPGLPGSTHSHASPFDLPSTSRPSMMRSVTDSHIYTGSPISKKRGTMNQPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0IV69</accession>
    <name>R0IV69_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_168387</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023914.1">
        <property type="nucleotide sequence ID" value="XM_008025723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IV69"/>
    <dbReference type="STRING" id="671987.R0IV69"/>
    <dbReference type="GeneID" id="19400530"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_3_2_1"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA88516.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
        </source>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">28A</strain>
        </source>
    </reference>
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        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
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    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
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    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYX0</accession>
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        <recommendedName>
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        </recommendedName>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
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        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="490" mass="53998" checksum="15158FFE9DD1D5D6" modified="2013-06-26" version="1">MPAMLDDPSAPIIFRTSGDVPYPPPGGPLPVGIAPCQVTLRDRVTTATIIPFSAPNQVPLTLLAYLCDQLGREIEKGDTYPMVEPLPLDNFGPYWFGVFGAIMLLGEVHDGRELHEMARRGCDWERECLGSFYIKPNYPGRSSHVCNGGFLVTDASRNRGVGRLMGETYLDWAPKLGYTYSVFNLVYETNVASCRIWDALGFKRIGRVKGCGNLKSYPGELVDAIIYGRDLGQDDEFVSEERFDKIRFYLKNGKYPNGADRAEKSRLRSAATHYKLTLGNDDEPEKLWLKGKEVIADPKQQYEIAQDIHHKHHGGINKTTAAIAELYHWVRIKETVSQVIRNCPECSEMNKGLSAMRQGQNQARAEARCASTFSSTTASQKPMPQTASTSLTPTPPSLFSPSQPPASVPSSSSDSPSTQIHVAQPAQPTHVFHHHHQQPFDLPVDPVLMDGIQSSVPATDIVRPVDLPPTSPFLPIAASTVNTQNETTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0J0N9</accession>
    <name>R0J0N9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_167236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022207.1">
        <property type="nucleotide sequence ID" value="XM_008024016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J0N9"/>
    <dbReference type="STRING" id="671987.R0J0N9"/>
    <dbReference type="GeneID" id="19400090"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA90336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="126" mass="13737" checksum="6E8DAF8D0D30EF3A" modified="2013-06-26" version="1">MAEDNSAAWPQADQALSQEILDLVQQATHYRQLKKGANEATKTLNRGISELIILAADTSPLAILLHLPLLCEDKNVPYVYVPSKMALGRACGVARPVIAASITTNEASDLMGQIRTLKDKVERLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2I2</accession>
    <name>R0J2I2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbonyl reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_145116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021656.1">
        <property type="nucleotide sequence ID" value="XM_008023465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2I2"/>
    <dbReference type="STRING" id="671987.R0J2I2"/>
    <dbReference type="GeneID" id="19396792"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353339" description="Carbonyl reductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="42836" checksum="4E08F4890FCFA683" modified="2013-06-26" version="1">MLTIFAPLLLLAQGTFAAPVENAAAAATVGKIRGVRDPIYHLYLQASPKNASTPVLGPETAADEFTIGGTIQSKKTTKYLNIATASTSYKPLVWGDKGDTTAWGLEGDTIITVQGSSYGRRVVTGANKGIGLAIVRQLALQYPKSPLNNGPFLIYLTARDQGRGEAAVKDLEQDAQLKQAKALKADGGLAEIKFHLLDITSSDSIKALAGHLKQDHSDGIDFVINNAGIAMDGFDANVVKTTLNCNYYKTLEACHEFLPLLKPTGRLVNVASRAGLLSKYSEEVRSRFLASKTEDDVTAIMKDFAAAVEAGKEKEAGFPSAAYAVSKAGLIGGTRAFAKQVKDSGKEVLVNACCPGYVNTDMTKGNGTKTPDQGAQTPVMLALRDIEGKTGAFWSEEQEISWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0J2M6</accession>
    <name>R0J2M6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_112805</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020531.1">
        <property type="nucleotide sequence ID" value="XM_008022340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J2M6"/>
    <dbReference type="STRING" id="671987.R0J2M6"/>
    <dbReference type="GeneID" id="19395571"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
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        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343756" description="alpha-glucosidase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="192"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="344"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="786"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA91205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111593" checksum="11811AE35B22ACD3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4K3</accession>
    <name>R0J4K3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_133764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020904.1">
        <property type="nucleotide sequence ID" value="XM_008022713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J4K3"/>
    <dbReference type="STRING" id="671987.R0J4K3"/>
    <dbReference type="GeneID" id="19396219"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_0_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
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</entry>
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        </submittedName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Sds3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </location>
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            <end position="358"/>
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            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA91990.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0J560</accession>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
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    <dbReference type="EMBL" id="KB908481">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008022714.1"/>
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    <dbReference type="AlphaFoldDB" id="R0J560"/>
    <dbReference type="STRING" id="671987.R0J560"/>
    <dbReference type="ESTHER" id="sett2-r0j560">
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    </dbReference>
    <dbReference type="GeneID" id="19395614"/>
    <dbReference type="eggNOG" id="KOG4389">
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    </dbReference>
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    <dbReference type="OrthoDB" id="408631at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005145249" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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    <sequence length="214" mass="23455" checksum="1BDD3E4898373D36" modified="2013-06-26" version="1">MTSSPPSASCETPSTDNHFTLLHPSIAEALFTFEERVADFSAAFDLLSQQHNILAAKYDELLGTTLKLRTQLAIQVVALVKCQGQEYTYTQRGEAKTSHGGNVSSADDEDEGSKTKKFSSNMRENNCTATACNTKSDASPPTHQTPDLLSPLLSKDTKKTPRLILRLPSRPDGEKAAPTMANQGQSSKGRRAKRNESSFLHATTMKRRTKRVNV</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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        <source>
            <dbReference type="EMBL" id="EOA80883.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0JII4</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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            <strain evidence="10">28A</strain>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5296287at2759"/>
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        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="PANTHER" id="PTHR23502">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA81128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="521" mass="56431" checksum="6CD7FB7D264967DE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0JIQ5</accession>
    <name>R0JIQ5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_185131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KB908870">
        <property type="protein sequence ID" value="EOA81223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031147.1">
        <property type="nucleotide sequence ID" value="XM_008032956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JIQ5"/>
    <dbReference type="STRING" id="671987.R0JIQ5"/>
    <dbReference type="MEROPS" id="S10.014"/>
    <dbReference type="GeneID" id="19402092"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006529581" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA81223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="550" mass="61387" checksum="48A4972F1F4EE4BA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>R0JKX1</accession>
    <name>R0JKX1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">SETTUDRAFT_141791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030306.1">
        <property type="nucleotide sequence ID" value="XM_008032115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JKX1"/>
    <dbReference type="STRING" id="671987.R0JKX1"/>
    <dbReference type="GeneID" id="19396635"/>
    <dbReference type="eggNOG" id="KOG0650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011390_0_1_1"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="171"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="437"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA81943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="789" mass="88714" checksum="0DAAF2FF06DC0A69" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0JN20</accession>
    <name>R0JN20_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_121026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029686.1">
        <property type="nucleotide sequence ID" value="XM_008031495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JN20"/>
    <dbReference type="STRING" id="671987.R0JN20"/>
    <dbReference type="GeneID" id="19395836"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000254">
        <property type="term" value="F:C-4 methylsterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="142"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="301" mass="35437" checksum="034DB5B1323091A7" modified="2013-06-26" version="1">MNATSVLTPMAQDTYWGSFEEISKYNVQLNYLEKMWMAWYAWMGNDVLATGIMSFVIHEALYFGRSLPWIIIDCIPYFNRYKIQQHKIPTAWEQMQCALLVLLSHFTVELPQIWLFHPMCQYFGLETSVPFPSIYKIAYQLAIFFVCEDAWHYWTHRAMHASSFLYKNIHKIHHQYSAPFGLAAEYASPIEVMILGFGTVGVPIMWCAITKDLHLLTMYIWIVVRLFQAIDAHSGYEFPWSLHHFLPFWAGAEHHDVHHEKFIGNYASSFRWWDYVLDTEAGAEASKKRRERKMAKARKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0JN37</accession>
    <name>R0JN37_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_165087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029695.1">
        <property type="nucleotide sequence ID" value="XM_008031504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JN37"/>
    <dbReference type="STRING" id="671987.R0JN37"/>
    <dbReference type="GeneID" id="19399355"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000426">
        <property type="entry name" value="Aldehyde reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="338" mass="37796" checksum="192F4D5D22104732" modified="2013-06-26" version="1">MPDLALDTDATVVVTGVNGLVGSHVADQLLKRGYNVRGVVRDAEKHKYLVEYFGEKHRYAKFELVGVPDMTVEGCYDDVVKDIGGFVQVASPMGTILDVDEAISVAANGAINALKACAKSPSCKRFIFTSSSVAATFPHPDVEMSIDENAYNDEALQTLRKDPNTPGLYSYAAMKVETEKAMREWMQENKPDFVLVFVLPNMNLGAVLIPEHQGYPSTINLARQAWLGQHLEMFATFAGPQWYVHPVDCALVHVSALIYKDVGSERLFAFAEPWDYNKMLDIWRKLYPERKFPDPIEGLGVDKMEIPNKRAEELLTWVKGAGWDSLEKGLKEMTESWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNC8</accession>
    <name>R0JNC8_EXST2</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_34238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008031268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNC8"/>
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    <dbReference type="eggNOG" id="ENOG502T621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3785310at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="285" mass="29495" checksum="A09B9E9436BB0825" modified="2013-06-26" version="1">MHIMHTMHTLAFLAATGVAGAAAQAGQWGRLVEPAKFGVVARDEGCSEMPALCTDLVLLRGHETTLTYLCPETEVGNAGPTTSSAFVEPLASTSNGPAPTSEQPTTTTTVQSTMEVTVTETVLKATASSSFSLTPAIITWSFPAILPSDMKSLLSASPTWSSVKNVSSAMPHIPKSRPVTTRTSVSIDLTSFNLFPTHTVANSSSTASSTTVSSSAAYCKAPYANSTSHGGYNAPTLNVAREANSTETVTTIAPVATITGTGVAVESRVSFVALFLGVLVTALMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNF6</accession>
    <name>R0JNF6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_34274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029465.1">
        <property type="nucleotide sequence ID" value="XM_008031274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNF6"/>
    <dbReference type="SMR" id="R0JNF6"/>
    <dbReference type="STRING" id="671987.R0JNF6"/>
    <dbReference type="GeneID" id="19403896"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031225_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="621" mass="67674" checksum="CD9A529492B0BFF6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNK7</accession>
    <name>R0JNK7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_34331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Henrissat B."/>
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030972.1">
        <property type="nucleotide sequence ID" value="XM_008032781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZ89"/>
    <dbReference type="STRING" id="671987.R0JZ89"/>
    <dbReference type="GeneID" id="19399653"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_0_2_1"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA81537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17699" checksum="9C72428AF82F3ED7" modified="2013-06-26" version="1">MSDYGGDDYDGGAGDIEEPLIEFDEEAEPDLMDDEDDQPGGGEDPDNADPNDDNVVVSGDANAAAAAREAAKNTVTSEKDKKVPNDKRTTTPYMTKYEKARVLGTRALQISGNAPVLIDVEGMTDPLQIAAKELQEKKIPLVVRRYLPDGFYEDWTCEELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1E9</accession>
    <name>R0K1E9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_140099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029197.1">
        <property type="nucleotide sequence ID" value="XM_008031006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1E9"/>
    <dbReference type="STRING" id="671987.R0K1E9"/>
    <dbReference type="GeneID" id="19396539"/>
    <dbReference type="eggNOG" id="ENOG502SJT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047586_0_0_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="336" mass="35841" checksum="981184FA531F4C91" modified="2013-06-26" version="1">MSSGAVSLVLPRPGAETTLPPKTIAGPPEESFTSTFGALLPPARYLSTDNGKAAYYSMPPSPPPTPDTQSPDTKSPERVLFIHGVQTPALGMLPLARQLHSSFPTAHFVLLDLWGHGLSDTPVAPHTASLFHGLIDALLDHLQWPSAHMVGFSFGASLTAGYVALRATRVQSYTLVAPAGLIKSASFSAAEQAHLQPGSDEAAAQKWVLEFLEGGDLLVPADWEERVARGEVVAEAVRKWQMDKHPAHTASVVGIFRDGGVLDNQQRFEAAIATGVPAMVVQGEKDDLCTPGELVQLGFQHVFVVPDVGHAVVRERVPEVAEYGGDCQKFLLTGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K261</accession>
    <name>R0K261_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
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            <strain evidence="6">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="58" mass="6171" checksum="AE78700502EA4B6F" modified="2013-06-26" version="1" fragment="single">ISRLLIAGATPISPSESKIRKYGNDVEACVACGASLGFAHHACQCCESWNPQYCKTPS</sequence>
</entry>
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    <accession>R0K3C2</accession>
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            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
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        <property type="entry name" value="ADH-like_N"/>
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        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="26"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="359" mass="38838" checksum="EE048579F79E83C0" modified="2013-06-26" version="1">MNGHAASSQHGQPQAVPKKMKALQYSGPEKFAVETIDVPAIGDDDVLVKISACGVCGTDLHYHKGEFLAKWPLIPGHEATGTVAAIGKHVTNVAVGDRVAADALEPCRQCFHCTRRKPLLCENVTGYGGNVPGGMAEYCRYPARMVLPIGDLPDLEAVLLEPAACAVHGIERMQLQVGSRVLLFGCGPTGILLAQLIKMNGAAHLTIASKAGPKLDLARELGIADTYITISDDHAETDMHSLRTANPHGFDVVVEATGAPTVLEKALDYVRKGGKLVVYGVYDDRAKIAWSPFKIWENEVTILASFCSMGHLPHVLEYVNAGRLKLKGIANRRYRIEEWAECLEAVRKQEVVKAAIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0K3E1</accession>
    <name>R0K3E1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_119087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028487.1">
        <property type="nucleotide sequence ID" value="XM_008030296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K3E1"/>
    <dbReference type="STRING" id="671987.R0K3E1"/>
    <dbReference type="GeneID" id="19395770"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027160_1_0_1"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA84089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="497" mass="57777" checksum="B16841ED8E81F8F3" modified="2013-06-26" version="1">MLLEDQRQLHEDLERLEDAAAERLLEDPPHIRDRLARDHDIARFLEQIESQSSRLLKIYEDADGKKEDEVRALTHGDPMESFLKEVQSIKDFHNRYPNEPVENLEKAYKKRSPEDHAQSIAAIDSMFTGEEGFGRFFDLTTLHEQYLNLPVHQHARRLTYLQYLDLFDVFTPPQCNIRRDQKKSEAYFHYLKALQDYLESFMRRTKPLENLDRLFANFDKEFEELWEKDQVPGWEKVAPAAADGEAQGEGIWCSACKKGFSKETVYEAHLTGKKHKKAVQESQNGTQDGGKQANGAFADLQRFKECAVAEREFRIRKLAAAMQTERGDTKMNVERKQGMTERERQQELEQLYSETPESGAKEEDNDSDGEDKIYNPLKLPLAWDGKPIPFWLYKLHGLGVEFPCEICGNFVYMGRRAFDKHFNEPRHIHGLKCLGITNTTLFREITSIKEAEDLWKKIQKDKKKEKMMAENVVEMEDSEGNVMPEKVYRDLAAAGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5Q5</accession>
    <name>R0K5Q5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cadmium resistance transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_107453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023819.1">
        <property type="nucleotide sequence ID" value="XM_008025628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K5Q5"/>
    <dbReference type="GeneID" id="19395228"/>
    <dbReference type="eggNOG" id="ENOG502QV0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071117_0_0_1"/>
    <dbReference type="OrthoDB" id="3791566at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004676">
        <property type="entry name" value="Cd-R_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03596">
        <property type="entry name" value="Cad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30999" checksum="AA54A7B7AE1E7119" modified="2013-06-26" version="1">MQFGKSVGTACSSFVITNIDDMFVLVTFFAEASTSKTMTPLRIIVGQYIGFTAIITISMVGFGVSLVLPSEPIGFLGLLPILLGLWNLFQLLFPNKVEEAEETEEAEKSNIASMKSILKVSIITVMNGGDNIGTYIPLFSQAKGAEIAVYVVIFYILLGVWCLVAYLVMKQRHILHVAQKYANVVVPFLYIGLGIFIIVKSSCYPWSIERIDDSISSHPGKTIMAVVTTVLLLVCISAMLWLKLRKKAAVPHSNNSSTGHEAENLNDSTAVQQAKNSVSDNSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>R0K5T7</accession>
    <name>R0K5T7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_107543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023838.1">
        <property type="nucleotide sequence ID" value="XM_008025647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K5T7"/>
    <dbReference type="STRING" id="671987.R0K5T7"/>
    <dbReference type="GeneID" id="19395238"/>
    <dbReference type="eggNOG" id="ENOG502S0IF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036104_0_0_1"/>
    <dbReference type="OrthoDB" id="3246050at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="485" mass="54463" checksum="06544B3FB4D68F0D" modified="2013-06-26" version="1">MPKTAVFTTITPLPTGITRKSVIDMYHDHLAMIDLNPLVVERFMCKPPSYAPTDEYWSMWYTIKDKVSYLPGKLAQGSVSYHACFHDTADGLETHVYAPLGLDIRAKWSVGGRLPGEPKPPTEPDLKVPRHGLYIREDVRMTCSSLLLSFVKRTFKDSHGELVDKLVERAHILESNLANERLQALRNIDPGERMGHGDIFIAPPPDYHLSPTHNLQVPSPRYATHFRSQSDPVLSPGFSSSSTLNEHSDASPREAERPTSFTFVKEEKEVSSSAPEQNSYLLPATTYDGGFSQKKQRPASLGPVSPLGRCSEAFISERMISLMPLSPRSPYPPSQHKPISSLHAPRVSYTVEERPISFTFPFDPKQPFDRKSTTETTHSDQNNLLDDIDDAIDEFMYTLPSSTFQTLPATTYSPEPTLSSARYTPEPTLSSATYTPEPKLSSAKYYDPRHQRKDSAMPSQTSSEDDERPPVPLKDDKYRKGSIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6R4</accession>
    <name>R0K6R4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_20746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026923.1">
        <property type="nucleotide sequence ID" value="XM_008028732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6R4"/>
    <dbReference type="SMR" id="R0K6R4"/>
    <dbReference type="STRING" id="671987.R0K6R4"/>
    <dbReference type="GeneID" id="19402350"/>
    <dbReference type="eggNOG" id="ENOG502S675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343129" evidence="3">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA85229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="241" mass="25356" checksum="45388D4318705E86" modified="2013-06-26" version="1">MKLSTFIAASSASLALAVPAAPLEKRADFCDQWGSQVNGPYTTYNNLWGKGSATSGSQCTGVDSYSGTPHGRGLAGTHGQVKSYANVVTNVAKKQLSSINSLPSVWKWSYTGSNIIADVAYDLFTSSSPSGKEENEIMIWLAALGGAGPISSTGSPIATVTLAGNSWKLYKGPNGQMTVYSFVAQNQVQNFNGDLMEFVRYLTSKQGLASSQYLISAGAGTEPFSGSNAKLTVSEYSLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6V4</accession>
    <name>R0K6V4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_154846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    <sequence length="414" mass="44488" checksum="7FA7233326E85DA0" modified="2013-06-26" version="1">MSLKAIATFVLAASLAVAKPIAPVEAAPGVTKRQFDFNSVVNGFNSNNGGFNFINGFNNFNQQRRVIQVQEQSLQIIDNGGRQQIVQQVEQVLVVDRVNNGFNSDLNDLFRKSNFRNQFRNVATVVLVVQEIQVIIDDRRRGRIQQNLFAQRAIVANRGARQTQTVMIFDSRKLIAQDILGNNAFNNIGRFGGIAGATGVINANLPVKTDGVQVFDVKPTWTAMAQDPAETLGSIWQDALQDQQKADADKADNQLNQQIAQQEMKAMQQAMQKQNQTQTADNAQQKADAQKQADAQKQADDAKKAADAQKKADDAKKADDAKMAADAQKADAKKAADAQKAADAQKADDAKKAADAQKADAQMADSQKADAQKADAQKADAQKADAQMAADAAKASAPAAAADAAPPAASKRAE</sequence>
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    <accession>R0K7F8</accession>
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    </protein>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Zhong S."/>
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    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
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            <end position="449"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
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        </source>
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            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
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    </evidence>
    <sequence length="872" mass="95910" checksum="BA2A523EFA81AACB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0K7T1</accession>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>heme</name>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016935">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
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    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA84362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56720" checksum="36D2A0CF5121C8B1" modified="2013-06-26" version="1">MAAPDDAPATAVLLLSAGLAALVAYAVAAVTYNVYLHPLAKFPGPPLARATVYWKAYAECVQNRSFCHYLVELHARYGDVVRVGPNELHFANPKAYHDIYNNRNRWDKEATLYQSFNEDRSSFGFLTHAEAKERKHVLNPSFSQAAIRNAQPLCIDKTKQLCAAFERQAKASKSIDLFLAFRCMSVDVITTLCFGNPIHAVDAPDFKAPIVVALDASTPVSLYFKYSDLFKNFILKCPPKLSRVLSPLTAGLIDLNELLMHQINDLTNNPEKLKLLPHNMTVFHRLMDPDAHRDKKVPCTGSLYEETQALMFGGTDTTGNTLMVGAFHLLKEPAAWQKLKSELLAAWPLLEGEGPTLSELESLPYLNAVIKESLRLSSGVTSGLLRIVPSTGATISGVAVPPKTIVSCGSTFVHYNADIFPKPDKFVPERWLETPDLDNWLVAFSRGPRMCLGINLAWAELRLAFAHVYRKFDMTPAKPLPDKLLWRDVFLPYYYDEHLQVNMQLVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0K854</accession>
    <name>R0K854_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_104947</name>
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    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022981.1">
        <property type="nucleotide sequence ID" value="XM_008024790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K854"/>
    <dbReference type="STRING" id="671987.R0K854"/>
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    </evidence>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA84902.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="295" mass="33216" checksum="52DA992CA7C0F806" modified="2013-06-26" version="1">MLAYYCVYIFLFLLILLALCCVYRKSGAGKKLIGPAYIVALVFEIIAYILDLANLIMTQCGIYNNHAYEAIYTTANILYNLGIWALLFVVLYTLNSMLRRQLGSPGRIVTGIPLAVCGIVLALTIVYLGLVSYTWLNRAYNYDISSDSLVHPTQRLVLALRAIYLFSVMLSFALSAMNISALRRARLPGGDLVGWVVVLHVCMFIWALLAVVWTGMSIFTYDWALEASLAVMYVTAFFRTISFVVLLGIAKHVCWRNKVPAQQVYAPVMHRQGEHGYNGEEHNYYQAPPEIFHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA56</accession>
    <name>R0KA56_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box protein</fullName>
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    </protein>
    <gene>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022767.1">
        <property type="nucleotide sequence ID" value="XM_008024576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KA56"/>
    <dbReference type="GeneID" id="19397933"/>
    <dbReference type="HOGENOM" id="CLU_615636_0_0_1"/>
    <dbReference type="OrthoDB" id="3691658at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="51028" checksum="6AF7C74A2CCAF897" modified="2013-06-26" version="1">MINRAPEYPMPNCEPVQKVHCPQAAPGQRLLLDGLYTDVLSVIIDWICAEKEASHSYSVTRANHGFRKKGGTLFCLSLVNKRMRSLCISKLFEKVFRYTASMGELNRRLRDIEGNPLLPSLPSVLRAIKVCDIVTTSRGKNTRCRTRLARTLPKMECLTELSITHRKDVDISGLSATFDRKSVCLESVKRLRILSNGSWDFLIRACPNVKTLGLGFNLGHDDIMEAAQDLKHLKHLEICCHAWDVAGINRLRSFVPKIQSLVMRGALDPHQHASDFAIALNHFEHLRDIAITTLCHVSDEDLESQFSDDDSGTDSIIALLEIGVANFEDESLVRDEFYEHWSHMRCLYIVDDKARRQPHEPGEKPFWYPDDETITGEDAVFGVEKLSYDREGFLDLFSFPRPVSYCDEAYDPPFYRPMSRHEREDKEKRRYTSVKIRASHLDLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAH8</accession>
    <name>R0KAH8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_137720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027677.1">
        <property type="nucleotide sequence ID" value="XM_008029486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAH8"/>
    <dbReference type="STRING" id="671987.R0KAH8"/>
    <dbReference type="GeneID" id="19396425"/>
    <dbReference type="eggNOG" id="KOG3720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030431_3_1_1"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA85227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="523" mass="58511" checksum="C5D0B46D2CAAD3FB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0KB31</accession>
    <name>R0KB31_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_32657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027059.1">
        <property type="nucleotide sequence ID" value="XM_008028868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KB31"/>
    <dbReference type="GeneID" id="19403681"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1996"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344329" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="31"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA86072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="343" mass="38464" checksum="21AC20AE513DDF1E" modified="2013-06-26" version="1">MKTFLTALAFAAPGTALLRFPCAQLVIDRLDPLVTPGQAPSPHLHQILGGDSFNITMDPAKDMPGESTCTSCQFSEDFSNYWTAVLYFKARNGTYKRVPQIPNSGFDGVNGGMTVYYMQDGLYNFQQTSKVQAFQPGFRMFIGDVNARTREEAERFRQLTFTCLDDINTRDPQTLDFPDKPCKTGIMTAVRFPTCWDGVHLDSPDHMAHMAYPEHGTFETGGPCPASHPVRMSQLFYEVVWDTSKFNNLAEWPEDGTQPFVWSFGDATGYANHGDYIFGWKGDALQRALDSPCYVNCPTLKTQDATAMNKCTVPRVVNEDIDGWVTELPGGYQAQYIKKRWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0KD56</accession>
    <name>R0KD56_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_166710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021568.1">
        <property type="nucleotide sequence ID" value="XM_008023377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KD56"/>
    <dbReference type="GeneID" id="19399908"/>
    <dbReference type="HOGENOM" id="CLU_2086281_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="117" mass="13158" checksum="97EB26AD58C68545" modified="2013-06-26" version="1">MTLFKDYNNRYFSSIDNVELVRKSISTLCVSIPVNVCDIFWSYPYIVAWTAFAPLGAYIFVREVLMARGVIHDGRARRVVTILNSGFEDKLNTLLARHILGNAGSFPATIVYLAPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDD9</accession>
    <name>R0KDD9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_25026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021227.1">
        <property type="nucleotide sequence ID" value="XM_008023036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDD9"/>
    <dbReference type="STRING" id="671987.R0KDD9"/>
    <dbReference type="GeneID" id="19402865"/>
    <dbReference type="eggNOG" id="ENOG502S3E8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066479_0_0_1"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24422" checksum="47B53C6923B19507" modified="2013-06-26" version="1">MPTKLMLSFVAMDFLFAGCGGLLLGFALMSEQSMRATPTVDNVTKNLLLGQCPLTAGVVNAIFVFVTFLLSLPALFLPNNRGWLRIMGWLVVVCATFTLGLGVAIWVETLGTRSNLNVLWGAETPLIQSLLQQKFDCCGYFNSTSPPFVQDRTCPNTLVAAQKGGCIGKFSSFANSYLDQIFTAAFGIVGIDTILVLCVAMVLKYRTEQERYRHIDEKNGLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KFL6</accession>
    <name>R0KFL6_EXST2</name>
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        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_162274</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020746.1">
        <property type="nucleotide sequence ID" value="XM_008022555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KFL6"/>
    <dbReference type="STRING" id="671987.R0KFL6"/>
    <dbReference type="GeneID" id="19398333"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="111"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA91608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="383" mass="42411" checksum="FB255BDB91C46C01" modified="2013-06-26" version="1">MANSTIVSNAANLKKYLDLPQKGAVMAEYVWIDGSNGIRSKSKTLKKKVESLADLPEWNFDGSSTGQAPGENSDVYLRPVAYYPDPFRLGDNVLVMCETYMSDGAPNAYNFRHDAAIIFEKHKDADFWFGLEQEYTLLDEFGWPYGWPKNGFPAPQGPYYCGVGTGKVFCRDIVEAHYKACMYAEIAISGTNAEVMPAQWEYQVGPCPGIDLGDQLWMSRFLLHRVAEEFGAKVTFAPKPIPGDWNGAGLHTNVSTVETRGENGMKAIEAAMEKLSTRQAEHMAVYGSDNQLRMTGKHETASYDKFTWGVANRGSSVRIPRAVAAEGKGYFEDRRPASNGDPYQITGIIAETMYGKVEGADIARFAKKADTVETEMVIDVHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGA9</accession>
    <name>R0KGA9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_86869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020490.1">
        <property type="nucleotide sequence ID" value="XM_008022299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGA9"/>
    <dbReference type="GeneID" id="19405612"/>
    <dbReference type="HOGENOM" id="CLU_1744999_0_0_1"/>
    <dbReference type="OrthoDB" id="3698536at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="150" mass="16859" checksum="DB23F635417ED424" modified="2013-06-26" version="1" fragment="single">FGEAAKKSMFLKGLHTKLQEALATIDENLSYEQLVNKAVRTSDNLYRVGLVKLRATSSWVVDRPTTTTAQHEASLDVMDWEPSKVNQAREARGKPRRPPPDCYRCGELGHIAKYCQNATQVKKARPAPSNVRHKPQEEVDQVPSSDSEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGQ9</accession>
    <name>R0KGQ9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division cycle protein 123</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_160342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023873.1">
        <property type="nucleotide sequence ID" value="XM_008025682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGQ9"/>
    <dbReference type="STRING" id="671987.R0KGQ9"/>
    <dbReference type="GeneID" id="19398029"/>
    <dbReference type="eggNOG" id="KOG2983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034402_2_0_1"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">28A</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908559">
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA87962.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="137" mass="15700" checksum="E8442C2E8D730240" modified="2013-06-26" version="1">MDLIQEAIAEIELREPGDKFSYQAIAKKHGVARMTLMRRHRGETEAYGVRNLSLHPQHEKELVRYIDTLTERRLPPTKEMIQRFASDLAGKPVSESWVDRFIRRHPNHLISAHSKGMSKLRCTPIQEPSTACIQASG</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Znf622/Rei1/Reh1"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="400" mass="44515" checksum="D5B93E7897AC7C3D" modified="2013-06-26" version="1">MADETSGSRTVFPCNTCSLSFANSGLQRSHMRGAWHIHNLQRKVSGLPALSELDFAEREDECAKDTREKSRWNDSQSASSTAQRRIDGVHQETSETADSDADSDDYSSTSSAFQNDDDHDSEPALSTAKCLFCPLSFPQTQENLTHMCTAHSFFIPSAPVNLSIEPLLSYLAQLVFSHHECICCGRTKANVYSVQSHMRDTGHCRLDGKDYAEFLCEDRCEVEEDEEEEEMVEDGEAGDKVRMLGLTEMRLPSGVVVNSRLHNSIHDGEMRRNRPRTAHIRLKTSSQQQQQQPRAVATATSPCTATPTPSAAQTQALALSPLAHSISFPEPPTTSLVPNTRKQDLSLSGLSAEQLRSLVTLDKKMRRQEVSARNKFRDAAMRQPVKTIYYKTENPVYQAG</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908515">
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    <dbReference type="eggNOG" id="ENOG502TDD3">
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    <dbReference type="OrthoDB" id="2561193at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA89249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="196" mass="22098" checksum="500F94E58D7AF984" modified="2013-06-26" version="1">MSRNAYSAFQKHLLFFSTPTTPPRLTLGSVLRAAVSLGLDVPVAVLLSVSLRLLYAPLPYFWSPIIVDRIPVSSHRTQLESTRLLPEKTEYTCSDLLALLKQSEKQESAKGWLAHMIDQGHIIGFWTMAANTQTHTVSKHDVERFQQGNWEEAVVERRAGRHEVLPLWRGGPIWVGGHSWAVRKLFGVKVYNAKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJX1</accession>
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        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
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    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_147981</name>
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    <organism evidence="10 11">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
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    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
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    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
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        <property type="protein sequence ID" value="EOA89474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023242.1">
        <property type="nucleotide sequence ID" value="XM_008025051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJX1"/>
    <dbReference type="SMR" id="R0KJX1"/>
    <dbReference type="STRING" id="671987.R0KJX1"/>
    <dbReference type="GeneID" id="19396944"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_0_2_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344410" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA89474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="250" mass="27583" checksum="86B41856B98DC5DD" modified="2013-06-26" version="1">MRVPSIALVSMAAVGVVNAQGSVASWHPPTAGDSRGPCPMLNTLANHEFLPHNGRNFTLDNVKHALTTALNLTDELAELLNKFALTTNLAANATTWGLDTLSNHNILEHDASLSRADNFFNNDSTSFNQTVFDRTRAFWTAPWINIQMAANARLARALDSVKFNRQFALSELAGAFSAGEGAAYLLVFGDRQNQTANRDMVEFFFENERLPIQMGWKAPNPAISSTVLFDMSELIVNATNYQSEQMMTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKM6</accession>
    <name>R0KKM6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_25985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022401.1">
        <property type="nucleotide sequence ID" value="XM_008024210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKM6"/>
    <dbReference type="GeneID" id="19402966"/>
    <dbReference type="HOGENOM" id="CLU_2589398_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354240" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="85" mass="9159" checksum="F6A7CFB8A06D6CF1" modified="2013-06-26" version="1">MKFAIVISTILFGAVPALAGTRVWCEWADFAKVEGKCIDSAYNLPVVDIGTCCVVTTVEEVKFKSICKELNSNFNSGGYCKGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0KL05</accession>
    <name>R0KL05_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_176663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023997.1">
        <property type="nucleotide sequence ID" value="XM_008025806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KL05"/>
    <dbReference type="STRING" id="671987.R0KL05"/>
    <dbReference type="GeneID" id="19401486"/>
    <dbReference type="eggNOG" id="KOG1172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002289_7_2_1"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="233"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="568"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA88622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="622" mass="69181" checksum="212DF068955FD618" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>R0KLT3</accession>
    <name>R0KLT3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_148453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023548.1">
        <property type="nucleotide sequence ID" value="XM_008025357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KLT3"/>
    <dbReference type="GeneID" id="19396974"/>
    <dbReference type="eggNOG" id="ENOG502S2VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021590_1_0_1"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA88907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="537" mass="59854" checksum="0A063C9834CE3EA0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KM14</accession>
    <name>R0KM14_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_106004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023603.1">
        <property type="nucleotide sequence ID" value="XM_008025412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KM14"/>
    <dbReference type="STRING" id="671987.R0KM14"/>
    <dbReference type="GeneID" id="19395141"/>
    <dbReference type="eggNOG" id="KOG3369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_2_2_1"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA88982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="152" mass="17101" checksum="9BE1BB36B68B2A16" modified="2013-06-26" version="1" fragment="single">VFALFIISKSGGLIYNREFHSGMSKLSSNDYLMLAGSFHGMHAITAQLSPIPPARAPPPSATTPNLQTFPVRATGIEVLESSHFRIQCFQTQTGVKFLLFTEPQQPNVDTMMKKIYELYADYVMKNPFYTVEMPIRCDKFDRGLDGFVKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQH0</accession>
    <name>R0KQH0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_85741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="8">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <property type="entry name" value="Histone_AcTrfase_su3"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <dbReference type="Pfam" id="PF06985"/>
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        <source>
            <dbReference type="EMBL" id="EOA91479.1"/>
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            <fullName evidence="20">Gentiobiase E</fullName>
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    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="23">
        <location>
            <begin position="886"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="787"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EOA90912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="974" mass="106904" checksum="563E8396425A2E23" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KTJ2</accession>
    <name>R0KTJ2_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_166915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021734.1">
        <property type="nucleotide sequence ID" value="XM_008023543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTJ2"/>
    <dbReference type="STRING" id="671987.R0KTJ2"/>
    <dbReference type="GeneID" id="19399978"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="275" mass="29545" checksum="5ED8D0EF50D0A8E0" modified="2013-06-26" version="1">MGRLENKNCIITGGAGGIGLETGILFAREGANVLLCDISGPALEKASAKLKEVVPEAKKVETKITDVSKEADVQAMIDHVDSWGGVDVLFNNAGIMHANDDDAVNTPEKIWDLTQAINVKGVWFGCKHAVNSFRKHGKKKTSVINTASVVALVGSATPQLAYTASKGAVLAMTRELAMVHAREGFRFNSLCPAPLNTPLLQDWLGDDKEKRHRREVHFPTGRFGEAIEQAQGVLFLASDESSFVNGTDFVIDGGMTKCYTTPTGPPLDAPKNNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KUR7</accession>
    <name>R0KUR7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_30049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
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                <person name="Grimwood J."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <source>
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        </source>
    </evidence>
    <sequence length="501" mass="56793" checksum="EDE2067FF3FB68D3" modified="2013-06-26" version="1">MPRSKSSVGVSSAVMTSQEEPVQPTYRGYGTFAAQRQRRHSWHTRPCMQEAENFQLLLCNFLTELNCRLDFLEDYGHLKYDAGVEYAYNTLLAVRESCSKISDGAIEAGRRQASVFVETLEERYKDALERKETLGEKVLEGIVLMDSYLTEFETRAYTLGNGSLGTYAHDFYEEGLRKMDEGIEIAKGVVDGGLDKARRARETIELRVEHAVQRALARAKANGLIHYDDLPEPWRVNPHILKGYRFQEGKWACVRSIFGLHNELINIWTHLLGFVMVLAIAFYFYPSSTNFSMSTNADIFIAAVFFFAACKCLACSTIWHTMNSISHQTLLERFACVDYTGISLLVAASIMTTEYAAFYCEPVSRWSYMCITALLGIGGVILPWHPTFNRADMAWLRVVFYCSLALTGFLPFGQLAYTRGIEWAQYFYAPITKSLLVYVTGACLYASKTPERFFPGFFDYVGCSHNIWHVAVLGGIIFHYKAMQAMFTQALTRAQTSCSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0I6Y4</accession>
    <name>R0I6Y4_EXST2</name>
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        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_23616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I6Y4"/>
    <dbReference type="STRING" id="671987.R0I6Y4"/>
    <dbReference type="GeneID" id="19402692"/>
    <dbReference type="HOGENOM" id="CLU_171282_0_0_1"/>
    <dbReference type="OrthoDB" id="3689396at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA81236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12766" checksum="752E2D4F99A40B85" modified="2013-06-26" version="1">MADAIKKRVLSMVGDLSAPAYDKVAHWCHDAILYKILKLESVTYEPSKEHPHNARTVFSFVVPQEMCNVLSNMHGGAVAMVFDRVTSLTVSPCMKEGFWDAGHVSRNRKFCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>R0I7L0</accession>
    <name>R0I7L0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_98307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030909.1">
        <property type="nucleotide sequence ID" value="XM_008032718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I7L0"/>
    <dbReference type="STRING" id="671987.R0I7L0"/>
    <dbReference type="GeneID" id="19406363"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122515_0_0_1"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA81446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="139" mass="16231" checksum="859CFE0A0D1C78A0" modified="2013-06-26" version="1">MFAARSVARAAPRQALARAPARAGRRNYSSESPKQFAGAEDNEFNRERAHIQQHAGESGEFWRKLSLYVAVPCIIVASVNAKVRWDAHWEHVAHEEHEHPRSERPEYPYQNIRTKNFWFGDGDKTLFWNDKVNYHKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0I8H3</accession>
    <name>R0I8H3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_165414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
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            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029877.1">
        <property type="nucleotide sequence ID" value="XM_008031686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IBV3"/>
    <dbReference type="STRING" id="671987.R0IBV3"/>
    <dbReference type="GeneID" id="19406241"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_8_0_1"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052718">
        <property type="term" value="C:tRNA-specific adenosine-34 deaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000039">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA82885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="217" mass="23616" checksum="F4126C9BC02A0778" modified="2013-06-26" version="1">MDPDERAYHEGFMREAIAMAELALKSDETPVGCVFVRHGHIIGRGMNETNRTLNGTRHAEFVAIAGILAKHPIAILHETDLYVTVEPCVMCASMLRQYGIRAVYFGCWNERFGGTGGVLNIHSDPSVDKPYPVTGGIFREEAIMLLRKFYVQENEKAPEPKQKKTRELKTEILPMDVHQPKSAPSPAVPAPASSASTGSIPTLSSLANATTTVSGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICE2</accession>
    <name>R0ICE2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_156540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029868.1">
        <property type="nucleotide sequence ID" value="XM_008031677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ICE2"/>
    <dbReference type="STRING" id="671987.R0ICE2"/>
    <dbReference type="GeneID" id="19397637"/>
    <dbReference type="eggNOG" id="KOG0247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009436_0_0_1"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000091">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="453"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="943"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="548"/>
            <end position="555"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122728" checksum="A0C48D0C0037C66C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0ICW4</accession>
    <name>R0ICW4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_33516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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    <sequence length="187" mass="19978" checksum="1E86FAE933E82A0C" modified="2013-06-26" version="1">MSYTFSILSPLDVPLFTHDFGTSRSGGTGVANFTPSERALVPFILHSSLDIVEEVQWGPSSSSGSAPMYLKHIDKYQNCFVSCWITGGNTRFLLLTRPRDESLGLTSGGAGGARGSLAGGRSALSGGGGLYNPNSPATEEAVKNFMVDVYEAWVKTIMNPFFAVGNGDVIKSPVFRQRVATAAKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0IFH0</accession>
    <name>R0IFH0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_155170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028300.1">
        <property type="nucleotide sequence ID" value="XM_008030109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IFH0"/>
    <dbReference type="STRING" id="671987.R0IFH0"/>
    <dbReference type="GeneID" id="19397487"/>
    <dbReference type="eggNOG" id="ENOG502SEMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099097_2_0_1"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="3">
        <location>
            <begin position="26"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA83816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="188" mass="20733" checksum="C59181136EBB7353" modified="2013-06-26" version="1">MDIATTSRAYFAMPSPSPDEKISLQASNTVYTYHCLCSHLLLATTTPLPSLPTRRHSRDGAHIMPLPPPPSTSNRKNSASSNSSEDSNSDHYGLLLSTRQERQAEIITNESGFEKRYLQRCGRCDLVVGYQLDWQQFAVDRAGRREDYVFLLPDGFVKTSDMIANKMASASAAGGPMDSTVSVTEVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0II62</accession>
    <name>R0II62_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_20389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026890.1">
        <property type="nucleotide sequence ID" value="XM_008028699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0II62"/>
    <dbReference type="STRING" id="671987.R0II62"/>
    <dbReference type="GeneID" id="19402317"/>
    <dbReference type="eggNOG" id="ENOG502RXDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012627_0_0_1"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="110309" checksum="F70737D0B432FDC2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIC5</accession>
    <name>R0IIC5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_137144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027438.1">
        <property type="nucleotide sequence ID" value="XM_008029247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIC5"/>
    <dbReference type="STRING" id="671987.R0IIC5"/>
    <dbReference type="GeneID" id="19396398"/>
    <dbReference type="eggNOG" id="KOG4589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_2_0_1"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="75"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="358" mass="40100" checksum="8D3426274B82C955" modified="2013-06-26" version="1">MLSRRLFRQLTDSLLLGRCAHPKHAVCFASACATCSSPARALAPWTRHSSSSSTRWKSRQGRDFFAKEARVKGLKSRAAFKLLELNEKHKLFKPGQTVVDLGYAPGSWCQVAVNRTSPDGRVIGIDLIPAQPPRGVSTIQGDFLSPAIQEEVRAYVRDPELGRPRRQISSSVSEGLTEEELEEMQRGYIDIERQAHLDGADLEVIGQPIENKDGDASSAAKLSLKERDMQQGRVVDVVLSDMSAPWDQTTGFYKKSLSDPYFRMMNTSGNAFRDHAGSMDLCMAALTFVFDTLKTGGHFLCKYYQGPEEKAFETKLKRLFTKVQREKPESSRAESREAYFVALRRKETPTKEEVLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIM6</accession>
    <name>R0IIM6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_163627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027339.1">
        <property type="nucleotide sequence ID" value="XM_008029148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IIM6"/>
    <dbReference type="STRING" id="671987.R0IIM6"/>
    <dbReference type="GeneID" id="19398826"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="202"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="347" mass="37120" checksum="C8189D275372668B" modified="2013-06-26" version="1">MAEAKKTVLIIGGGAVGAIAAVNLEVGGLAAVTVVLRSNYNVVKEKGYTIHSCDHGVLDGWRPSVVRNTVPNLVEEGIPPYDYVILCTKNIPDASPTAVELATPALPKNSGKTTLLLLQNGINIEKPFLRAHPNVPILSGISMIGSAEPSPGHIVHDEADKLLIGAFPTSNINPAVPERRAEELVAIYGKAGKTDCQYSPEVLHDRWKKLVFNAALNPICAITGLDDGRIRLADGALDGLVRPAMREIVAAAKAVNGVELGDDVVEATINIDPLESYLKPSMQQDLEKGNWIEFENLVGEPLRAGKNAGVPMPTLEVLYHIAKAIQWRTREKRGLVSVPPKGSNSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJ12</accession>
    <name>R0IJ12_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_117351</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84936.1"/>
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        <property type="nucleotide sequence ID" value="XM_008029253.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
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    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
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        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
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    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EOA84936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1042" mass="111601" checksum="C0DEC10313AA5A92" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0IK84</accession>
    <name>R0IK84_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_89961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA85520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027879.1">
        <property type="nucleotide sequence ID" value="XM_008029688.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0IK84"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>FAD</name>
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        <source>
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    </evidence>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">28A</strain>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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        <source>
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        <source>
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    </evidence>
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        <source>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">28A</strain>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Bushley K.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="758" mass="84524" checksum="DE223D6404B031CD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IXL9</accession>
    <name>R0IXL9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_127972</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023129.1">
        <property type="nucleotide sequence ID" value="XM_008024938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IXL9"/>
    <dbReference type="STRING" id="671987.R0IXL9"/>
    <dbReference type="GeneID" id="19396036"/>
    <dbReference type="eggNOG" id="ENOG502QT6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046802_1_0_1"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353304" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="196"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA89326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="319" mass="33827" checksum="C4C531E1C2083CE2" modified="2013-06-26" version="1">MHISSLLYPALLVASGADALRSDRVKLSNIQSLTLRKGQQTSARRVDPIPQLKCIGGSARGLYEPEVMRCKNSGSDYDEDSIQWTCTASLPEEFKLGSTDVICEGYDYPEDPYILKGSCGVEYRLILTEKGREKYGKGRGGWEGDDDDRPDGPKTMGEKIAAGLFWLLFGGVVLWMIYSAFTNRAQAQDGGFAGGNRPGWGGGGGGGGGWGYDDNNDPPPPYYPNDPTNPNNPKSGYGTTQGWRPGFWSGAAGGAAAGWAAGRFANRGNRSSQGGGWGSGSGSGTRWDNGGEGSSRSSSGDSFSSTRYESTGFGGTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0IY17</accession>
    <name>R0IY17_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_25946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022399.1">
        <property type="nucleotide sequence ID" value="XM_008024208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IY17"/>
    <dbReference type="STRING" id="671987.R0IY17"/>
    <dbReference type="GeneID" id="19402964"/>
    <dbReference type="eggNOG" id="KOG3428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123956_3_0_1"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502SVIN">
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="125" mass="12657" checksum="0873204139B329EE" modified="2013-06-26" version="1">MVSSQQGYSNTTIDMKGNTQAVNEAQSNLPLPDQPPVASDFNSSDARTVNVGSGGQEASFTSGGGAIREPAVGAGGVSGREAKDGLSGIPNDAVSREAKNHSGLADTTGKDYGYPKNDPSSGIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </comment>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="282" mass="29862" checksum="564E1B8F3719D09C" modified="2013-06-26" version="1">MADFDPSNVFNVKGMVAVITGGGTGLGLMMAQALEANGAIVYILGRREEVLKQAAATAKHGNIHYFKADVTSKADLSAAADHIGAKSGYVNLVIANSGITGPTLHGLNKGASLAETQKYLWNWDSDEFNQTFTLNTTAAFFTAVAFLDLLDKGNKAGNIEQKSQVVFVSSAGAFSRMPMAGYAYAGSKAAIIHIMKQLATSFAQHGIRSNALAPGLFPSEMSAPILAKQEVWPRDFIPEERPGDIKDMAGAVLFLTSRAGAYVNGTVLLQEGGRLSIIPATY</sequence>
</entry>
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    <accession>R0J2J4</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <location>
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        <location>
            <position position="422"/>
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        <ligandPart>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="EOA91160.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="1124" mass="126189" checksum="707F6C3B1C275EAB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0J370</accession>
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    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021252.1">
        <property type="nucleotide sequence ID" value="XM_008023061.1"/>
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    <dbReference type="AlphaFoldDB" id="R0J370"/>
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    <dbReference type="GeneID" id="19402890"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
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        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
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    </dbReference>
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        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
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    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
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    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
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    </dbReference>
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        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
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        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SDHA_APRA_LASPO"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="47"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="499"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="442"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EOA91161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="635" mass="68312" checksum="804960C5FE2DCC5F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4U2</accession>
    <name>R0J4U2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA-box-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_87224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="2127950at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
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        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27257" checksum="125FA190A1971C1C" modified="2013-06-26" version="1">MDPNSLTSHPSTAAQAQTFVAPGSLSYPQGANLDMTAPSTEQNTQQVADNANGVATPAATPDTQNGQVPSGIVPTLQNIVATVNLSARLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALVFASGKMVVTGAKSEDDSRLASRKYARIIQKLGFSAKFTDFKIQNIVGSCDIRFPIRLEGLASRHHTFSSYEPELFPGLIYRMMKPRIVLLIFVSGKIVLTGAKVREEIYQAFELIYPVLSDFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0J520</accession>
    <name>R0J520_EXST2</name>
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        <recommendedName>
            <fullName evidence="4">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_162401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020876.1">
        <property type="nucleotide sequence ID" value="XM_008022685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J520"/>
    <dbReference type="STRING" id="671987.R0J520"/>
    <dbReference type="GeneID" id="19398382"/>
    <dbReference type="eggNOG" id="ENOG502QRGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032158_1_1_1"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="181"/>
        </location>
    </feature>
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        <location>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="49113" checksum="907245C6AC51D404" modified="2013-06-26" version="1">MSYLQNSLRRFRRTQLHNVETFKGQPLDELSGSLGDLGTLLPLMTALVITNSISLPSTLLVTGAANILTGMAFGLPLPVQPMKAIAAVAIARKFSQNETAAAGLVVAGFVGVLSITGLLNWANRVTPVPVVKGIQVGAGLSLCVSAGSNMLLPLTWTGPWWGDNLLLALAAVVLLVCTFAYPRLPYAIIIFAAGILLSLASPGNENAHAPDAAVSLLRPSGHDFWKATTTASLGQLPLTLLNSVIAASALAADLLPSPPYPAAPTVTELGVSVAAINLVGCWFGAMPACHGSGGLAGQYRFGARSGASIIVLGIVKFTLGLVAFWKSPGIIAVLDNIPKSLLGVLVLAAGIELAKVGESVNTNARDLRVLDRDHAWDGKRVKDLDERERKERWMVMLVTVAALLTFKNDAVGFIAGLAWHWGFEIATRIEGWRHGEVDGPVWRTVGHGRDERTSLLAHTESDTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0J5G5</accession>
    <name>R0J5G5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial inner membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_162530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020971.1">
        <property type="nucleotide sequence ID" value="XM_008022780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J5G5"/>
    <dbReference type="STRING" id="671987.R0J5G5"/>
    <dbReference type="GeneID" id="19398421"/>
    <dbReference type="eggNOG" id="ENOG502RY8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045137_0_0_1"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030131.1">
        <property type="nucleotide sequence ID" value="XM_008031940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JLU0"/>
    <dbReference type="STRING" id="671987.R0JLU0"/>
    <dbReference type="GeneID" id="19403965"/>
    <dbReference type="HOGENOM" id="CLU_1166460_0_0_1"/>
    <dbReference type="OrthoDB" id="3693807at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA82198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="238" mass="26004" checksum="62945913F351BB9E" modified="2013-06-26" version="1">MSNTPPVAPEYISSPPANPPSLLSQSLAPQSTSPNREVQSTPNRELPCTPPGREIPCTSPPGAPTAPVRQRVEMIFPFPNQDAPPTVEQPPSHASSDPIRMPRRLRSSTTPRVPPLHYQPLRSYLPASWRPLPARVHHRDDTVVHYCALGSNGWEAMQQERVRRSQEDIGKIDVAWAASGGGVILNFKRDRKGKGREGQGQGAETVSVEDEGEGEQGSEGDGGLEEERGEEADDERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0JLU7</accession>
    <name>R0JLU7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_23447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030068.1">
        <property type="nucleotide sequence ID" value="XM_008031877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JLU7"/>
    <dbReference type="STRING" id="671987.R0JLU7"/>
    <dbReference type="GeneID" id="19402673"/>
    <dbReference type="eggNOG" id="KOG2524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036001_2_1_1"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA82208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="364" mass="42403" checksum="5142D924428C2EFE" modified="2013-06-26" version="1">MSDDDVDLELLELMRKHWGGGARQDGPPETKVLENAQFIYDNSIDVALDMRSTKVAAQLVLDEMSKRDYSPRSWSEHELHPKSKDEAAVNFIFTMDLLNFSFWSEKSDQERFAVVYKGKRWTGYWSLVAILQRALEQEIPITSPEFWVDEETCSEEVLRTVFSSGTDEEIPLFEQRVRCLREAGQVLQEEFDSSVVTLIEDANNSAAGLVNLLAERFNCFRDEGKFENKNVRFLKRAQIFVADLWAAFEGDGYGTFNDIDKITMFADYRIPQMLHSLGIMWYCPPLENKIRRLEMIDSGHTWEMQIRGCSIWAVELLRREIKKLKPDTQVNAILIDFFLYDLAKEREKEGVDAIPHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNB8</accession>
    <name>R0JNB8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_95951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029731.1">
        <property type="nucleotide sequence ID" value="XM_008031540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNB8"/>
    <dbReference type="STRING" id="671987.R0JNB8"/>
    <dbReference type="GeneID" id="19406196"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003059_1_1_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="480"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="7">
        <location>
            <begin position="484"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="7">
        <location>
            <begin position="518"/>
            <end position="522"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <sequence length="1157" mass="127969" checksum="719B777AFE273A22" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0JRU4</accession>
    <name>R0JRU4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_138486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028317.1">
        <property type="nucleotide sequence ID" value="XM_008030126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JRU4"/>
    <dbReference type="STRING" id="671987.R0JRU4"/>
    <dbReference type="GeneID" id="19396461"/>
    <dbReference type="eggNOG" id="ENOG502SNUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006524_5_0_1"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA83838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="666" mass="74270" checksum="D1F18125D137BE31" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JT17</accession>
    <name>R0JT17_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_119314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028571.1">
        <property type="nucleotide sequence ID" value="XM_008030380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JT17"/>
    <dbReference type="STRING" id="671987.R0JT17"/>
    <dbReference type="GeneID" id="19395778"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="127"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA84213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="601" mass="67120" checksum="942E264F0BB0A290" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0JT61</accession>
    <name>R0JT61_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_24230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
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        <property type="protein sequence ID" value="EOA80714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JT61"/>
    <dbReference type="STRING" id="671987.R0JT61"/>
    <dbReference type="GeneID" id="19402756"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_171_0_1"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="178"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="269"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA80714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028053.1">
        <property type="nucleotide sequence ID" value="XM_008029862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JTB9"/>
    <dbReference type="GeneID" id="19402471"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA84328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="556" mass="62615" checksum="162A18CFEF825203" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0JUK4</accession>
    <name>R0JUK4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_91402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">28A</strain>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
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    </dbReference>
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        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
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        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="60"/>
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            <end position="278"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA81314.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="286" mass="30799" checksum="59D414647D2C72C6" modified="2013-06-26" version="1">MTEYAKMKNDELSALLKERKLPHTGKKAEMVERLQKDDEKANAKPAAGAEDEIDWDDDDAAAAPAPATSTTAAPAAEGAIPNEKIVEKAGGEGQPPNPQAVPNQVADIDPAKTDDLTSSAPAEGTAEESAETKPEEKKEPAPDYSRGLAATNLDEEIEKRKKRALKFGTKLEDDEGLKKLERAKKFGEVGPPKGLDEALPERRQKRGREGGEDAGSNKRREAGRDAGRDAGRTGGRGGRRDNRTRDGRDNRRSEHKTGSGEPTGWMSEKDRAAAEARKAKFAKPAA</sequence>
</entry>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    </gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
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    </feature>
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        <location>
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            <end position="217"/>
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        <location>
            <begin position="168"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="239" mass="23472" checksum="AA5DAF9C28803260" modified="2013-06-26" version="1">MSKIFSAALLASCAAAQLTTSIWMPGADSGGVSLKASVVKVDKDRTTMSMALPTESGSSELADIAQTITVAGNTYYGFDANAADMGASVYIVGQCTRKDTSEKVATCTISTKGLDAAISSFCGGDDADPDVCSGGSALETSMTTTLPEGYVGMFPIVITAGENLLPSASAGGSPSATGASATASSTPSGSQAVKSDKPTASGSKDASPTSKSTDSAGAAPIMTMVPALAGLGAAAAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_163932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
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        <property type="protein sequence ID" value="EOA85253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029503.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0JWC5"/>
    <dbReference type="GeneID" id="19398953"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1924260at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA85253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="311" mass="35377" checksum="39F5B85DD0900E4A" modified="2013-06-26" version="1">MSGGWNTIESDAGVFTYLIEKLGVKDVQFEELTTLEASDLQNLGTIYGVIFLFKYPTGEKASDVPKDGTYDYEAANSLFFPAQTIQNACGTQAIVSLLLNREEEIDIGKELKEFKEFAGDFPPELRGETLSNSDLIRETHNSFARSSPFVDETQRTVTEDDDVFHFIAYTSIKNTLYELDGLQPAPISHGPCTASEFPQKIIPVLQRRIARYPATEIRFNLMACCRDLRIRAREIGDEDELEEQEDKRARWLWENSLRRHNFVGFVGELLKSVVRAKLDQGGDAYDKWVDEAKGRSAKRREELRKQGIAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0JX43</accession>
    <name>R0JX43_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_156917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030383.1">
        <property type="nucleotide sequence ID" value="XM_008032192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JX43"/>
    <dbReference type="STRING" id="671987.R0JX43"/>
    <dbReference type="GeneID" id="19397681"/>
    <dbReference type="eggNOG" id="ENOG502SJPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA82054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="351" mass="38109" checksum="17D455BB7B9B9F3D" modified="2013-06-26" version="1">MTIRSRPQMFDILIIGSGPAGLNAALTCARTRTTALVFDSQQYRNEGVTHMHTVASRDHFNPREFGRIAREQIESQYDSVWFQQATITHATKKQLVLPQEKVPYDGFQITDSEGHSYKGKKLILATGSRDILPDLPGYKENWPSHIYQCLACDGYEQRGSAVGILDFNSPMYAHMVQMALPLDPSSITILNNGPTKQDAAIHDALKLARGLGATLDERNIVRLVNNGPSHTDGVTVHFETGEPVTLGFIVHKPATVNRAQHLIEQLGVETVDPAMGGHVKIASPMFNETSVRGVFAAGDTMVAMKQVAIAMAEGLKAAAGAGMQILQENAKGLAEAEKVVGGDEEKEKVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYG0</accession>
    <name>R0JYG0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_28887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026385.1">
        <property type="nucleotide sequence ID" value="XM_008028194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYG0"/>
    <dbReference type="STRING" id="671987.R0JYG0"/>
    <dbReference type="GeneID" id="19403287"/>
    <dbReference type="HOGENOM" id="CLU_013929_8_3_1"/>
    <dbReference type="OrthoDB" id="5420958at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="229" mass="25979" checksum="68BB548BBDA992F3" modified="2013-06-26" version="1">MDPASQAFAQRLPEGVRDTCAARSEHGDVPVSTLIHRRLGRRSRAEQAQSQQYLTREEEKALVKFLLLMSNLGQPVRVKYLRSLAFSIARQRSTKSESIKRPGKNWPRAFEKRHPELQARRDSCVLPENVYNMDETGVMLSMLDSAKVLVGEDDRQGSRGAGVKRTMVTAIECISANGRALLPLIIWPASTHRSNWTTYSTPGWHYAHSENGYNDSKISLEWLKRVFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYT8</accession>
    <name>R0JYT8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_157343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA81412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYT8"/>
    <dbReference type="GeneID" id="19397724"/>
    <dbReference type="eggNOG" id="ENOG502S978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066070_0_0_1"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="290" mass="32013" checksum="9F192E656EA5C3F9" modified="2013-06-26" version="1">MAPLRRYLRITKHSVLEVRIYLDRPSDGEAWLLKRDDAALPRVIQAVRPLVLPKLREENGRGKGRGGARAKKKGVKDVVIQDDFEVSIFLTELSCRHSVLSKQKIFKDRARIQSNSGKLTSWLTTTTATGTIDEPVVINEDIAPPIVIREEDGDEPADLSNIPEAKSVEKQRRYTAHQNRRSDTRSADICSHWSNGESLDMSISGAEITKAGASNAGHDSGDGPRADDKKKLGLNTSYDGFSIYGRILCLVVKRRGGRKPTSAASSQAILETWVSTQAVKDHVDDDEDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZB7</accession>
    <name>R0JZB7_EXST2</name>
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        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_151300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008028023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZB7"/>
    <dbReference type="STRING" id="671987.R0JZB7"/>
    <dbReference type="GeneID" id="19397114"/>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_024722_3_1_1"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008860">
        <property type="term" value="F:ferredoxin-NAD+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="359"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA86223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="449" mass="49339" checksum="0B3C1D3E792AF013" modified="2013-06-26" version="1">MNKNHDAIVDMYEQLPVPYGLVRYGVAPDHPEVKNCQDTFEEVAQSPRFNYIGNVRVGFDVDLVKMKPHYDAMLFSYGASEDRQLGIPGEDLPGVYSARSFVGWYNGLPQFRDLRPNLHAGEQAVVIGQGNVALDVARILLSPVDALRGTDIADQAIQALSESRVRSVRVVGRRGPIQAAFTVKEARELMQIPSVAFEPIDRSLYPPDIKKLPRVQKRIAEVLLKGSKASLQDAPRSWALEFMQAPKAMHADGDHLSSITFTKQNFVPDGDPFDQKTRVVPTAEESTMEASLAFRSVGYKSTALPGLSDLGVPFDDRLGIIPNDMHGRVMTPSAGPGNLTAGHVPGLYCAGWVKRGPTGVIASTMQDAFASAEIIAQDWEAGVPFLNDNRSTGLGWDAIKDAVESKGVRPLSWADWKKIDGAERERGRARGKEREKFQSVEEMLNVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZG4</accession>
    <name>R0JZG4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_166000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">28A</strain>
        </source>
    </reference>
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        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
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    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
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        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
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        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
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        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="340"/>
            <end position="468"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZR0</accession>
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    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
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            <end position="39"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82117.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC transporter E family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="229"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="506" mass="57156" checksum="6E223B0FF5011DBC" modified="2013-06-26" version="1" fragment="single">MPRPGQVLGLVGTNGIGKSTALKILSGKLKPNLGRYDNPPDWEEILKYFRGSELQNYFTKVLEDNLKAVVKPQYVDQIPKAIKATDRSVGKLIKARSQMENLDEMIDDLELRHIFDRDVGQLSGGELQRFAIALVCVQQADVYMFDEPSSFLDVKQRLAAGRKIRSLLRPDDYVIVVEHDLSVLDYLSDFICVLYGKPAVYGVVTLPASVREGINIFLDGNIPTENLRFREESLQFRIAEAGDEYMADHNRGYSYPSMKKTLGDFELNIESGAFTDSEILVMMGENGTGKTTFCKMLAGALQPDGDTKIPKMSISMKPQTITPKFQGTVRQLFFKKIKAAFLSPQFQTDVYKPLKMDDFIDQEVQNLSGGELQRVAIVLALGMPADIYLIDEPSAYLDSEQRIIASRVIKRFIMHSKKTAFVVEHDFIMATYLADRVIVFDGQPAVKARANKPESLLTGCNTFLKNLDVTFRRDPNSYRPRINKDRSQLDQEQKLSGNYFFLEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1U7</accession>
    <name>R0K1U7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_33893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028842.1">
        <property type="nucleotide sequence ID" value="XM_008030651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1U7"/>
    <dbReference type="GeneID" id="19403832"/>
    <dbReference type="HOGENOM" id="CLU_586841_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="466" mass="51977" checksum="562E514C03544D36" modified="2013-06-26" version="1">MCNIITHQYTCTHVLPHIRSICNARIVRRKSRSFTSTSTTTSSSSSSSHSYTSTTTTTTKPACTASPLLTLHHTTPCPTCLYKIWLQTWLDKSSRSKKFLRLLQERDGDDGGEEEDTRVVRELVSALHQKMQAEMWMWSRIEGIGLGLGFGFGLGGGREKRRRRRRRVGNGNGNGNGRRGSVLRFEVYASDIGMPSEGYEEEEEEEEEEGEEEEEEKEKDKSGYERDSEWNSETDWKWKWECDSESRNPTTTREFENDGLGIGIGISDSLATYNADTTSWSNHGHGDRNHGKTDSDLFDHSFWTQDIDADADTDGDIDADADGDVQRDSDINPSTWPWDPPPPPSPPTLLLPTTTAIAQPFNAANPEYQTPDSEDHASELDTIITSHTPSSLVAWDSSDVETTPSTALNANGDLYTTTTTTTTTAEHHDEHTRKVVAAFWSVVNGTTEISSASVLRLLHDFRQDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4D9</accession>
    <name>R0K4D9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_139581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028980.1">
        <property type="nucleotide sequence ID" value="XM_008030789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K4D9"/>
    <dbReference type="STRING" id="671987.R0K4D9"/>
    <dbReference type="GeneID" id="19396514"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="9">28A</strain>
        </source>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="282" mass="31343" checksum="69B5081A3FA1986C" modified="2013-06-26" version="1">MDFSNSAFRTAPTSKVSDDVMSHANLVMACRWGWTSSPDADGGGANSPSATSTQPSSSASTFNNVRSKRFAPCQGRLYHQLLCSHRIRTDLVEDCGANCVEPYGNAVGAAFICHECIQGEAAKIWGERQAQHNALYPRMEQMTQEQYDQWYAEHQQLEADFSRDQQVYEMELKAKTRPSNICSAMEASKEEMEFANELDCLSLSLMASNTSTADQAPPQIQGRTRTSLATDPEEQLHWDLNTLALDRGSCGIEYSASHPSSGVNSTRQLDTDKLWRKPRNLD</sequence>
</entry>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908504">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K9A2"/>
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    <dbReference type="HOGENOM" id="CLU_1653204_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="160" mass="17645" checksum="B3E11FC189463235" modified="2013-06-26" version="1">MLTRALHNRIAIRAYPVLLALALALVLLGLLADSLSLVPGLEVGVVLVSKVVGVAVLDCHVQDEESEEDSEEEEESEEEGEDEDEDEGEDEVSEEDEGEGEEEEEEEEEEEEEEEEEEEDEEEDEEDDEEADSTGHDDAVASVFVLIDVVLDEETPGGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA16</accession>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
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    <dbReference type="GeneID" id="19395729"/>
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    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24094">
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        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343904" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="211" mass="22226" checksum="C379B7CCE64537A3" modified="2013-06-26" version="1">MKASLLIAAAASLGLTSAAPTSSSPLAARAPPNVPSKAEATSQLAGLTVAAQGPQTGYSRDLFPHWITQSGTCNTRETVLKRDGTNVVTNSACASTSGSWFSPYDGATWTAASDVDIDHMVPLSNAWKSGAASWTTARRQAFANDLTNPQLLAVTDNVNQAKGDKGPEDWKPPLTSYYCTYSKMWIKVKSVYGLTITSAEKSALTSMLATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R0KB00</accession>
    <name>R0KB00_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_162808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025232.1">
        <property type="nucleotide sequence ID" value="XM_008027041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KB00"/>
    <dbReference type="STRING" id="671987.R0KB00"/>
    <dbReference type="GeneID" id="19398547"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_2_0_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
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        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLYHDRLASE47"/>
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    <keyword evidence="6" id="KW-0106">Calcium</keyword>
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    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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            <begin position="1"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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</entry>
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    <accession>R0KBI7</accession>
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    </protein>
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        <name evidence="1" type="ORF">SETTUDRAFT_169700</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="129" mass="14918" checksum="A630765B5AD3B354" modified="2013-06-26" version="1">MVKIVFNEKLSEGHNSLVTAQDIRLFFEGYFRGCGIWIYRRVSPSNRLVAVKWVVVLSHEKDLPYSEWNRCALVLESHGYLLYRTIRLLDSTDLSVLDRWAKGCTTLEGSAKHIRDVLLRMGSEWLGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0KC62</accession>
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        <recommendedName>
            <fullName evidence="12">Laccase</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_19500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA86979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026729.1"/>
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    <dbReference type="AlphaFoldDB" id="R0KC62"/>
    <dbReference type="STRING" id="671987.R0KC62"/>
    <dbReference type="GeneID" id="19402207"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_8_3_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13873">
        <property type="entry name" value="CuRO_2_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13895">
        <property type="entry name" value="CuRO_3_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
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        <property type="entry name" value="MCO_CuRO_3"/>
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    <dbReference type="InterPro" id="IPR017762">
        <property type="entry name" value="Multicopper_oxidase_fun"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03390">
        <property type="entry name" value="ascorbOXfungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344319" description="Laccase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="53"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="178"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="424"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="67794" checksum="96279434C79E934E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDH0</accession>
    <name>R0KDH0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_169312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026197.1">
        <property type="nucleotide sequence ID" value="XM_008028006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDH0"/>
    <dbReference type="STRING" id="671987.R0KDH0"/>
    <dbReference type="GeneID" id="19400862"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_0_1"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="295"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA86202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="349" mass="36537" checksum="78794E3DB0D2035F" modified="2013-06-26" version="1">MFSVARQSALRVARTRLSQPQPTIVPQYSAFARLASTLAILEQKEGKILPQSLAAITAGTKIGGSITAFVAGSGVKSAADEAAKAKGVEKVVYVENGAYDKSLPENYAPLLVENIKKGGYTHVIAGQSAFGKNIMPRVSALLDSQQVSDITGIESEDTFVRPIYAGNAIMTVQSSDSTKVITVRGTAFPAPETEGGNATVEEGVDPKAECLTEWISEDLQKSDRPDLGSAEKVVSGGRGLKSKEEFDKLMTPLADALGAAIGASRAAVDSGFADNSLQVGQTGKNVAPQLYLCAGISGAIQHLAGMKDSKVIAAINKDPDAPIFQVADVGLVGDLFEKVPELTEKLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDX6</accession>
    <name>R0KDX6_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_28165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908581">
        <property type="protein sequence ID" value="EOA87529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024710.1">
        <property type="nucleotide sequence ID" value="XM_008026519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDX6"/>
    <dbReference type="STRING" id="671987.R0KDX6"/>
    <dbReference type="GeneID" id="19403220"/>
    <dbReference type="eggNOG" id="ENOG502T6D0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1705346_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012361858" evidence="2">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="154" mass="13418" checksum="257F00177278177E" modified="2013-06-26" version="1">MKFTAVLFMAAGALAAPVVERQVGIPPSPSGGAPPFPSGGFPGFPSGGFPGGPAPTGGFPGFPGGGAPGGGFPSGGFPGGGAPAPTGGFPGFPGGGAPGGGFPSGGFPGGGAPAPTGFPGFPGGGAPGGGFPGGGAPGGGFPGGAPPAPTPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KE28</accession>
    <name>R0KE28_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_158562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA91098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021747.1">
        <property type="nucleotide sequence ID" value="XM_008023556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KE28"/>
    <dbReference type="STRING" id="671987.R0KE28"/>
    <dbReference type="GeneID" id="19397833"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="5">
        <location>
            <begin position="448"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="577"/>
            <end position="578"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA91098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="597" mass="63961" checksum="F9BBE45AEB05A84D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KE29</accession>
    <name>R0KE29_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxymethylenebutenolidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_169177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908593">
        <property type="protein sequence ID" value="EOA86417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026027.1">
        <property type="nucleotide sequence ID" value="XM_008027836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KE29"/>
    <dbReference type="STRING" id="671987.R0KE29"/>
    <dbReference type="GeneID" id="19400819"/>
    <dbReference type="eggNOG" id="ENOG502QWD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032662_0_0_1"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46988" checksum="4EA3AC885D940612" modified="2013-06-26" version="1">MGGAPITPPLETGPALTPPKAQRISPHVTLQAPLSRRGRGPGLVLVLDHYAAIEASEKHLDPPPLQKWAEEGFAVVQLLVPGNAAEDGGEFPLQKALDVLKACKGCEFDKGVGLISYLTRIPYYVEEGACQNAHIKALVSYGGRKFISLSATSHPPQLIHTSGPPVAHRRASSTESVGITPGIVKTYRYEDAEKDSSWILPSDPDYHKRNAGIAHTRSLTFLKPLLGGPFFDLEAVWEEHTKYEFGDRDVGKTMATMVDQPYVNHIPTMAGGIGKDRLTNFYTHHFVFSNPPDTALSLVSRTVGIDRVIDEFVFSLTHTKHIPWLLPGVPPTGKRLAIPFTSVVALRGDRLCHEHISWDHATLLKQCGLLPDYVPFPYEIKGVTREQGKRFEVPLPVVGEEGSRKLVDEGSEESNPLMGAQWRVVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0KF14</accession>
    <name>R0KF14_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_27845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Ciuffetti L."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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                <person name="Barry K.W."/>
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                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023009.1">
        <property type="nucleotide sequence ID" value="XM_008024818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJ30"/>
    <dbReference type="STRING" id="671987.R0KJ30"/>
    <dbReference type="GeneID" id="19396917"/>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076409_0_1_1"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27575" checksum="3274FE635199C059" modified="2013-06-26" version="1">MAQPNPSAPNETSAPYVDPTFSLVNTSCLDLLLIELVPMAYRITADLAAREEEWIHGSSGAKPKRLSGASNDASSTAAGTVRGTDGGPVGAGGTATVDEEESREAVFHRLEALGYRVGLGVVERFSRDAPRPTTPLDCIKFLCKDLWMLLFRKQIDNLKTNHRGIYVLTDNTFKPLGRMSFDTKKYDAAMQAALVAQTGDPALGRDANSQARVQPFLYFPAGLIRGCLASLGIQATVTAESAALPGATFQIRTAGAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>R0KJP4</accession>
    <name>R0KJP4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_167885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023189.1">
        <property type="nucleotide sequence ID" value="XM_008024998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJP4"/>
    <dbReference type="STRING" id="671987.R0KJP4"/>
    <dbReference type="GeneID" id="19400336"/>
    <dbReference type="eggNOG" id="KOG4017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053731_0_1_1"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA89404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="412" mass="47088" checksum="F1916CDC921D4207" modified="2013-06-26" version="1">MSERQATPPRATHSAGKLPPNPPTPEQIRRMEEARLKAKAAAQQAQASRPSPAPVAGEKRAYSAITASQTPATLRNAAAASPPKRDQNGFIQPPANDYIQPAKKYARSDFIEYDFSKMTDTKGGFLSTEDDPHNKAMRKGQAKEEQKPEGMTMPEWEKERIRRKLRANRAGPYEPGISILNTVDGKEEEDEEAALLEAAENAEIESGTFKGRYGDGKRDVKGKCRECNSLEIDWKWQDIFNVGVCNICKEKYPDKYSLLTKTEARDDYLLTDPELKDEELLPHLERPNPHKQFFHPMQLFLRLQVEAYAFSPAKWGSPEALDEEYAKRQVISKERKQKKFKNKLEDLKKRTRVEAYKRARLAGDADAQFGQKIKGRYDRHEHEWGRSVLDPETGMTRKRCEECGMEVEELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KKP9</accession>
    <name>R0KKP9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SETTUDRAFT_107074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KKP9"/>
    <dbReference type="STRING" id="671987.R0KKP9"/>
    <dbReference type="GeneID" id="19395210"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="EmrE-like"/>
    </dbReference>
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        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="155"/>
            <end position="174"/>
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    </feature>
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        <location>
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            <end position="342"/>
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            <end position="421"/>
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            <end position="62"/>
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    </feature>
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    </feature>
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            <end position="508"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="551"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA88542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="551" mass="60160" checksum="8A5563D3EAC5A473" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0KL35</accession>
    <name>R0KL35_EXST2</name>
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        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_160522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024018.1">
        <property type="nucleotide sequence ID" value="XM_008025827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KL35"/>
    <dbReference type="GeneID" id="19398047"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000295">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="364"/>
            <end position="383"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA88652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55815" checksum="BB5D815C396C1D62" modified="2013-06-26" version="1">MASAGEKPGVLDVERVSNASADAAVAYEEGKAAVDGAVVCTDEDNKRIVRKTDFWMLSLLCMVYFLQSADKGIIGLTAVYGLKKDAKLTGNDYSNIGNIGYYAQLGVQPLAAWILVKLRYRHVLPVIIVCWGISVAGGLGGSTNYAGLMASRFFLGAFEAAPFRVACWYSCYGLSTLISAPIVYGFGRIHSPHLYRYQIVYLFFGCLTIAIGLITYWWAHDSPGEARFLSPEDRLKAVERVKANQQGINSHKFNWKHVTEAMTEPKYWLYMIMVIAVNAGASVSSVFGSIILQNLAGFTADEAVLLNMPFGALQFVSILLASWLAYRFKRKSPFLLILVTIVIVGVALLVGLPKTKDNKAGLLVGYYLIAFVFAINPLLISWMGANCAGQTKKAIYYTSFNAGNSIGNIITPYIFDKKFAPQYVNALKGILSIWCVLWGVVIAQVFVIMWMQKKKCDEREAAGLPRNPIDYSMSGHQQDADAEVHGENGLQDMTDRENIYFQYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0KML7</accession>
    <name>R0KML7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_102306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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    <sequence length="317" mass="35765" checksum="5BA75AE4FCD7679A" modified="2013-06-26" version="1">MDDEYLIPEPRSSDIGPSRNVAFRRDSSGIQDHGHVIDAPSLSHLVSEMVRRGLIMVPHLQELRVLGFANTEWQSLLASAEMTLCELALQPSAYNLTTIDLQLEMSTRGPNNCLSSLVEVTKRTIKLKVLRIRSGPKALSQYRIPTEYWAPLLKQLGERKPPFKLHTLDLDGLATSKVAPTLDRIVAAHSCSLRRLVLGHTNFHYPNTLYAFFSALAKSDVSYFELSWLFLHHKSLLVASSLSFAQVPDEVLKMGVKDLRSDCDMSNYDWIVIRWDVDRHDAAVVYDNEDGFYGQDWIKRCCQNALTSIECGAIDDS</sequence>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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    </reference>
    <dbReference type="EMBL" id="KB908482">
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        <property type="evidence" value="ECO:0007669"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021286.1">
        <property type="nucleotide sequence ID" value="XM_008023095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KP38"/>
    <dbReference type="GeneID" id="19404120"/>
    <dbReference type="HOGENOM" id="CLU_1732609_0_0_1"/>
    <dbReference type="OrthoDB" id="3662064at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA90834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="151" mass="16978" checksum="64103D5C84133ED9" modified="2013-06-26" version="1">MASSTLDTSFSQQPVLSSSPDKTVTQGSVGTFNHCLPPISEYEWDFGWEENTFPLADPYEGFEQVPATAVESIAHDTTLRQKHEDLAELGNKVQKLRHDISELHDMFCKRLDSIEKSIAVADSYVKHLVPWSVEVHEKYSQLLAIAAKQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQV4</accession>
    <name>R0KQV4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_167114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022069.1">
        <property type="nucleotide sequence ID" value="XM_008023878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQV4"/>
    <dbReference type="GeneID" id="19400039"/>
    <dbReference type="eggNOG" id="ENOG502S9ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039661_0_0_1"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000236">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="6">
        <location>
            <begin position="161"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="389" mass="44737" checksum="BC5C857566E9C816" modified="2013-06-26" version="1">MGPQGRWRRVLLIALVPMVVAFIYYSTPTSYMPAGLTSAPYPHTQNITLPQDDLSMATIIKALYGPIIHPIDAANFTDEDGDVYRLAGEPRFKTPLGKKVLILDIDSRPLTDEGQLMNQHLKWKGMRSLSAGMLGHYMFAQIHGYDYKFIRAPDYEDRWGTWVKVPMMKEALKTHEYIVFMDSDVMFHYPHLPLEWLLNYWNMTDDTLAMMSIDPNEPQNYDEKGNRYLNTGFVIARQSKRTQEMYKAWAECPSETRYKGCAKWKKGWAHEQAAFGNYLRYDFDRPNDIRVLPCVEANGAPEAEKRGGCKGVFVRHFWVDKGLVAKNLADNVMQYFLPRLHEAYLGSANEHIVDAKGFRLEGADLIEMTDAEKEAAKKEKGKNQKDEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQW7</accession>
    <name>R0KQW7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_158799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022082.1">
        <property type="nucleotide sequence ID" value="XM_008023891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQW7"/>
    <dbReference type="STRING" id="671987.R0KQW7"/>
    <dbReference type="GeneID" id="19397870"/>
    <dbReference type="eggNOG" id="KOG1581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036019_0_2_1"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120112">
        <property type="term" value="P:UDP-glucose transmembrane transport into endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA90182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="412" mass="45021" checksum="18E5E48B7A254D15" modified="2013-06-26" version="1">MAQAVRRKANETNGHANGNAHHRLDDAVHSIEQKLEEQAELHARNPQEQKEAGLFQLVICVAGIYGSFMTWAWIQERLTTTSHGPRNERFTYSIFLNTVQSAFAAITGLAYLFLSASKDPKTGVRKVLPIFPSRAILVPLLGIAITSSLASPFGYASLKHIDYVTFILAKSCKLLPVMFLHISLFQKRYPLYKYAVIGFVTLGVAVFTLYSPSTAKKAAKKSGAVNAEASQTIGLVLLGVNLLFDGLTNTVQDHIFTTFKGFTGPQMMCAQNIMSTALTVSYLLITPLLASTPLAASLGLATDELSSALNFITTYPSVGWDVLMFSACGAIGQVFIFHTLAHFSSLLLVTVTVTRKMLTMVWSVWWFGHEITSMQWVGVGLVFGGIGAEAAMGRREKAKKAAAKKAEMEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KR68</accession>
    <name>R0KR68_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_162210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020686.1">
        <property type="nucleotide sequence ID" value="XM_008022495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KR68"/>
    <dbReference type="STRING" id="671987.R0KR68"/>
    <dbReference type="GeneID" id="19398300"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA91499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="480" mass="54759" checksum="C6960621F2559E98" modified="2013-06-26" version="1">MAQSYLPKDFLWGFATASYQIEGAPHEDGRADSIWDSFCRIPGKIAGGESGEVACDSYHRTDEDVALLKELGAKSYRFSLSWSRIIPLGGRNDAVNEKGLQYYLTLVDKLHAAGIEPMITLFHWDLPDELHKRYGGMLNKDEFVKDYENYARVCFKAFGSKVKYWITFNEPWCSSILGYGTGLFAPGRCSDRSKSAEGDSTREPWIVGHSLLIAHGAAVKAYRDDFKAQDGGQIGITLNGDWTEPWDPEDPKDREACNRKIEFAICWFGDPVYFGKYPDSMRKQLGDRLPEFTPDEVALVKGSNDFYGMNHYCANYIRHRDTEPELDDHAGNLDVLYQNKKGEWIGPETQSAWLRPMPLGFRKLIKWLSDRYGGPTFYVTENGTSLKGENELPLEQLLDDEFRCEYFRGYIGALADAHTLDGVDVRGYSAWSLMDNFEWAEGYTTRFGVTYVDYKGGQKRYPKKSAREISKIFDKYIQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KR80</accession>
    <name>R0KR80_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_126278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022189.1">
        <property type="nucleotide sequence ID" value="XM_008023998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KR80"/>
    <dbReference type="STRING" id="671987.R0KR80"/>
    <dbReference type="GeneID" id="19395985"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044629_0_0_1"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000014">
        <property type="entry name" value="SET domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="30"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="479" mass="54085" checksum="EC1E1ED0D97BD563" modified="2013-06-26" version="1">MIRRGRAEGWLKQPIDALPTWATFHGVRFNNVKIGPLPGHEERGSTVIADESLQSSANPLLVVPKELIISRQNIDLVAKADHHLHELLEALGDFGRTTRGAVLTFLLLQATMCCPHTTEVGVLNPLTEYIKFLPDELLPTFWTEEERELLVGTTLKPAVSAKLNSLLREFENLRTATESIPWCHKYWWSEDNGMLTFDDWMRVDAMYRSRALEFPGAGDCMMPCVDMANHASGDATGALYETDSNGNGLLLLREGKNIEKGGEVTITYGDDKGACESIFSYGFLEDAMTSARAMFLDLDVPDDDPLRPAKKYVSTEAPGFRIFEKDGTIDWEGDFIWLVVVNEEDGLDFKVRQTTDGKRDIQGFWKERVLDTSRLRQHLEEDAAWDVFQLRATVLLQNRIDEQIEILKGAQGMKHEATVRDVPWRLAERLRSLELEMLQRAASVLGNQRAQLLDSPTVIHYLGLDGAEAEEEEEEDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRI9</accession>
    <name>R0KRI9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_113483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020747.1">
        <property type="nucleotide sequence ID" value="XM_008022556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KRI9"/>
    <dbReference type="STRING" id="671987.R0KRI9"/>
    <dbReference type="GeneID" id="19395596"/>
    <dbReference type="eggNOG" id="ENOG502RYK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008378_0_0_1"/>
    <dbReference type="OrthoDB" id="5310959at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="93"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA91609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="693" mass="75751" checksum="4AD35BD341B28C85" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSY9</accession>
    <name>R0KSY9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_166810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021626.1">
        <property type="nucleotide sequence ID" value="XM_008023435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KSY9"/>
    <dbReference type="STRING" id="671987.R0KSY9"/>
    <dbReference type="GeneID" id="19399937"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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                <person name="Henrissat B."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <source>
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        <source>
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    <sequence length="373" mass="40412" checksum="10E2639CFE43D18D" modified="2013-06-26" version="1">MSTPSTIVTAPMNTSTTYQPTSYVTNMDISYDSLPSSLDDASDRFSSQAGSLRLDSWGLSNDDAMSGFLTNDSPSFHSPPTFEIDGSGSSADFPDSFGHMQVGCMDTTSHGQHSHILECNARLCNLNLDLSKRLQECLGTTPQGSPRLYNAKPEDGSTGDRDGINTTLERALGDLSEFIAVIRSYVSTRNDFDRGNPTGEPIGQGVGSGPGISATPKISLVFLINLLSAYLQLVTIYDKIFSPHRTRLCSTASLEPSCTSPSQQPLDFRLLGLSAAQGTLQTKILIHAILHQFDVIERMLGLPADLRVTDTQDVYLGLFEDERARSLLGAVSNAKRIETSWAQAQFNMEDYGGANALSALRMTLKVMQGFLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0I708</accession>
    <name>R0I708_EXST2</name>
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        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
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        <name evidence="13" type="ORF">SETTUDRAFT_165846</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008032661.1"/>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
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        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KOW2_Spt5"/>
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    </dbReference>
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        <property type="entry name" value="Spt5-NGN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Spt5"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
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        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
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    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
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    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="12">
        <location>
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    </feature>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
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        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="1011" mass="108153" checksum="1252AB9FEED1925D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0I788</accession>
    <name>R0I788_EXST2</name>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_98454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I788"/>
    <dbReference type="STRING" id="671987.R0I788"/>
    <dbReference type="GeneID" id="19406374"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_5_1"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA81430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="332" mass="36755" checksum="17ABAD2F57FB7683" modified="2013-06-26" version="1">MAPTITHERGAKMGIYVIAISGGNTLGPLICGFIVTNLSWRWHKWISVIFTGLNFVAILFLVPETRYRREGFGQAGVTVGLSTDDVAIADEKMPQRSFTGLSLKQVQHKTWKQELFLWSGVEKTNLAKMFVRPFPMVVYPAVIYAFLGYSISLVLTVAVNMLNPFVLQAPPYNWSPQINGLINIPGIVGNVFGAWAGGNLVDMWCRWRTRKHHGIYEPESRLYLVIIPLILTTAGCILFGYGVQNELSWVSLFFGYGMISVSLTAIPTITMAYVSDCALPVNADVLLLVNGLKNIVAFGFLYGVVPWVEDTGYVNVFGIMAGIFAGTRKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0I7E2</accession>
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    </gene>
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        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030870.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I7E2"/>
    <dbReference type="GeneID" id="19397721"/>
    <dbReference type="eggNOG" id="ENOG502SPRR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084275_0_1_1"/>
    <dbReference type="OrthoDB" id="4831122at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004352781" description="Celp0028 effector like protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28037" checksum="B2D82A08BD542FCF" modified="2013-06-26" version="1">MHLTSLLALAASAVMVAAAPTSNIVVMEDEVVLYGSGRYQIMKRSEFHEKFSDYYFNQSSVPAQIDTRGITTYTSEQIEEIVVRETSNKIKRDNGDVVIMGQKTRFLGWDVQISPIVKGGPNTGTFVAVAAGYSISNSIAIGVSAKLGLIEKVLSVSASFLRTWTTTNTQDQTLSFFVPPGKIACWVSNPWTNRQEGWVWTGTIGQQGSLEYWRADQFESKQYNNLAWVDGVMQTCVGDDYPLKRCSGAGFLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0I814</accession>
    <name>R0I814_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_64978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030743.1">
        <property type="nucleotide sequence ID" value="XM_008032552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I814"/>
    <dbReference type="GeneID" id="19405312"/>
    <dbReference type="HOGENOM" id="CLU_044119_0_0_1"/>
    <dbReference type="OrthoDB" id="3781946at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA81655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="336" mass="37931" checksum="24583BA67434D8BC" modified="2013-06-26" version="1" fragment="single">RTSSKTFNWQALPTELKEHILTFCLHQSPPPGLSRRTKGAPEVTGQLGDWDSLLSVSRQVRTLCLRLCLSGSSSLVYKHGLCIDVDTHRDFKDCIRRLGKYFQLLEPNSLPHDATTQLLAKTYRDFPLAHAHLARYATLRHGIRKLHLEFSFLDCMHFFRVTVAHFPRFYPHFRLDYRVLDSLSGLVAVAVRLPDPTGYLVDRVPQCGPRLFYGDPYTCPRILHRVIYEAAAEAMAPCGFFALYGFMDYDEKARFEALRASASAKVKFTTDQLGELYAEDQPGGGGVQLGEWIQPGVDAAAAAAAARSDVDEELDFVRDTFWPPKCRCKVRCSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0I9W1</accession>
    <name>R0I9W1_EXST2</name>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <name>[4Fe-4S] cluster</name>
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        <property type="project" value="InterPro"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Lucas S."/>
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                <person name="Ciuffetti L."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
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        <subcellularLocation>
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    <comment type="similarity">
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    <dbReference type="STRING" id="671987.R0IIX8"/>
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    <dbReference type="OrthoDB" id="436262at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001056">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="113"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1068"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="857"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="930"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA85095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1252" mass="139075" checksum="A3E44BDB6D38EF21" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJ63</accession>
    <name>R0IJ63_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_163883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027640.1">
        <property type="nucleotide sequence ID" value="XM_008029449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJ63"/>
    <dbReference type="STRING" id="671987.R0IJ63"/>
    <dbReference type="GeneID" id="19398928"/>
    <dbReference type="eggNOG" id="ENOG502RXB4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009827_2_0_1"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="365" mass="41046" checksum="6F962D80C9118F06" modified="2013-06-26" version="1">MSTIQAAVLDQVGRPSVSIIGNITLCGRTVSLAQTFGLHRDPSKWSITENEKSLRIRLWWCVLITDQWSSVAYGAPPYLSKGYYDVPRPTVTSLIGSRASPHQKQATTCFVHLCGLTELLAEIIPFVYQIKPDRLQLAREIDRFKLELNGLEAQLPEWLPMPNRSGTAMLWLSFLSIRLVLARVIFRAAVLDGDGSIGRNRMHQLRNASSAVLEFILTMGEIQFLDFWLPYATHLLVHAITVSLRCTVETQDPEIRNTSVARLERVIAHIQYARDNYDWDIANYCLERCADPVSKIASLNSREALQPSETEPTTVVANGNGTEMHTMPNFDDASFLLSDILDPNAFDFSWDALWDTPSGMTNFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJM0</accession>
    <name>R0IJM0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_179819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027755.1">
        <property type="nucleotide sequence ID" value="XM_008029564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJM0"/>
    <dbReference type="STRING" id="671987.R0IJM0"/>
    <dbReference type="GeneID" id="19401714"/>
    <dbReference type="eggNOG" id="ENOG502RJY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012440_1_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Lowry S."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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            <strain evidence="4">28A</strain>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="similarity">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
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        <property type="nucleotide sequence ID" value="XM_008025811.1"/>
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    <dbReference type="AlphaFoldDB" id="R0IVM9"/>
    <dbReference type="STRING" id="671987.R0IVM9"/>
    <dbReference type="GeneID" id="19395205"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_5_1_1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="33"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="199" mass="21336" checksum="AC4EC9A65502B0BA" modified="2013-06-26" version="1">MSDAASDIDGQVAVGSSDHISGIDQAYLATGPDYKAAILFHHNVIRANHHAAPLSWDSKCEENARIAANRCNFEHFIPKGAGQGQNLFTVSGRAFNVTAAITESWYHGELSPMMPWFGKASLPHDVFEKVGHLTQLVWKGTTKVGCVSLDCGTAMTVDGRPSTMNKYTVCNYAPAGNVVGKYAVNVVPPQSTNAIGWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVQ3</accession>
    <name>R0IVQ3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SETTUDRAFT_128655</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023526.1">
        <property type="nucleotide sequence ID" value="XM_008025335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IVQ3"/>
    <dbReference type="SMR" id="R0IVQ3"/>
    <dbReference type="STRING" id="671987.R0IVQ3"/>
    <dbReference type="GeneID" id="19396058"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="22">
        <location>
            <begin position="62"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="23">
        <location>
            <begin position="512"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="67"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EOA88875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="647" mass="70940" checksum="9C8819113278E892" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0IWP9</accession>
    <name>R0IWP9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute symporter family transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_46077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022939.1">
        <property type="nucleotide sequence ID" value="XM_008024748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IWP9"/>
    <dbReference type="STRING" id="671987.R0IWP9"/>
    <dbReference type="GeneID" id="19405028"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA89160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="72481" checksum="0102759A4B7FCFF5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0IYI0</accession>
    <name>R0IYI0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
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        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_167449</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB908504">
        <property type="protein sequence ID" value="EOA89596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022578.1">
        <property type="nucleotide sequence ID" value="XM_008024387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IYI0"/>
    <dbReference type="STRING" id="671987.R0IYI0"/>
    <dbReference type="GeneID" id="19400179"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_2_1"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021465.1">
        <property type="nucleotide sequence ID" value="XM_008023274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J163"/>
    <dbReference type="SMR" id="R0J163"/>
    <dbReference type="STRING" id="671987.R0J163"/>
    <dbReference type="GeneID" id="19396779"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003033_2_0_1"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1124"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="777"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="813"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="973"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1003"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1057"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1098"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA90680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1261" mass="135567" checksum="5C05B88BBBBFEDCD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1C5</accession>
    <name>R0J1C5_EXST2</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_101519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021524.1">
        <property type="nucleotide sequence ID" value="XM_008023333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J1C5"/>
    <dbReference type="STRING" id="671987.R0J1C5"/>
    <dbReference type="GeneID" id="19394864"/>
    <dbReference type="eggNOG" id="ENOG502S1RY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1678251_0_0_1"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
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    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA90775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="161" mass="17300" checksum="6F92EEC02220EAA2" modified="2013-06-26" version="1" fragment="single">GMPPGLANMFSAMQGGGGAAEPSPDQSSAWIWRLVHSIFSLGLAIYIVLQTPFTGSKLSRDNVADDDWATESSPAQNFAHFFYLFATFEVVLQTSRYYIEKGQLQGSGILSTVAGALPEPYAGYVRTVGRYSVIYSTVVSDAMVVVFVLGASSWWRGAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1M9</accession>
    <name>R0J1M9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_166606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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                <person name="Henrissat B."/>
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                <person name="Ciuffetti L."/>
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                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="OrthoDB" id="6077919at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA91006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="317" mass="34269" checksum="A0F550B5BE029DA2" modified="2013-06-26" version="1">MSGVAASSYPLQAPAHPQHQQQRPQSPPSPPAEEKKPSLPSISSLLEFAGNDKTASSDSGATQPQPQQQQQQSQPQATRPEQFTAYTPASAPATSRMTLPPTPPMHPDVAHDGNQSPSAASNHSAASTPYFVGGALNNMEPHQQRQSFSVPSMKRESMQQSHSMSPYSTSVYGQSPYQSSPGAASSASFYSPEQHSYNSSQLYTQRPLPSNFQPHSMPLPVPVPSPAANGSNPWQHHHYISTSSQSQFPQPQDRYICSTCNKAFSRPSSLRIHSHSHTGEKPYKCPQPGCGKAFSVRSNMKRHERGCHAASSTTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>R0J442</accession>
    <name>R0J442_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_18199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020056.1">
        <property type="nucleotide sequence ID" value="XM_008021865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J442"/>
    <dbReference type="GeneID" id="19401883"/>
    <dbReference type="HOGENOM" id="CLU_1750814_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA91516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="149" mass="16516" checksum="3495E09257CE7182" modified="2013-06-26" version="1">MMWQPVSWKHRLPQSETCIVGPEKAALPTAECSTAVETFTALNNICNYDMCNIGYTATKGCRGFLSLVLGDITASSFGASMACGSLLATRLAAGYRRNTRPIMRHIWKQCSPKGMLHWFPPKPPELAVIFEDMFFKSTIEKRGPLGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0J4B2</accession>
    <name>R0J4B2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SETTUDRAFT_30290</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020216.1">
        <property type="nucleotide sequence ID" value="XM_008022025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J4B2"/>
    <dbReference type="STRING" id="671987.R0J4B2"/>
    <dbReference type="GeneID" id="19403424"/>
    <dbReference type="eggNOG" id="KOG0420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_6_1_1"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Condon B.J."/>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="entry name" value="Endochitinase-like_sf"/>
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        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
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        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
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        <property type="entry name" value="E set domains"/>
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        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
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        <property type="entry name" value="CHIT_BIND_I_2"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5004353529" evidence="5">
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            <begin position="18"/>
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    <feature type="disulfide bond" evidence="3">
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            <dbReference type="ARBA" id="ARBA00022669"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50941"/>
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        <source>
            <dbReference type="EMBL" id="EOA81433.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    <sequence length="811" mass="85398" checksum="DD1D62DF5656D9B3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0JKB2</accession>
    <name>R0JKB2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SETTUDRAFT_99403</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA81733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_008031109.1">
        <property type="nucleotide sequence ID" value="XM_008032918.1"/>
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    <dbReference type="AlphaFoldDB" id="R0JKB2"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
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    <dbReference type="UniPathway" id="UPA00850"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
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        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
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        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
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        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
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    <dbReference type="AlphaFoldDB" id="R0JL19"/>
    <dbReference type="STRING" id="671987.R0JL19"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <location>
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    </feature>
    <feature type="chain" id="PRO_5004353586" evidence="1">
        <location>
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            <end position="305"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="305" mass="33266" checksum="683E9F5571A8E4B2" modified="2013-06-26" version="1">MRYLLISFATLAIGASLKTTSNTSLDCNDQAIACTAASSSTDCSAVYQTCAIACINTYNSCSATSDPTCDDTLHTCLGAAPNSTSRLPSDNIGSTNSSDVALHVAKRASSWYFPDPVELCRARKLVFFEHTTTNCLAQRGNEFTYTCRHPSTDNVRTYVDVCQNTYTCQQVNNDGTAPRTPIPNPYTQSRALCVRDEKSGTSAGRGDTGRVCPQQGSSIRKFFGKVYSKSKETLKRVIYVTENRGSGEIVSIAGQEENVLEYDLSYNIDPTNDICIYAIIIAALTIPWGWDSRFVDKSVFPPHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0JPR8</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_164592</name>
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    <organism evidence="2 3">
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83138.1"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">Kelch repeat-containing protein</fullName>
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    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_163737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="85830" checksum="70145853A446561C" modified="2013-06-26" version="1"> </sequence>
</entry>
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            <fullName evidence="13">Polyketide synthase</fullName>
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    </gene>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908692">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR036736">
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    </dbReference>
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    </dbReference>
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    <dbReference type="Pfam" id="PF00698">
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    </dbReference>
    <dbReference type="Pfam" id="PF22621">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
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        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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                <person name="Ciuffetti L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029369.1">
        <property type="nucleotide sequence ID" value="XM_008031178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZ09"/>
    <dbReference type="STRING" id="671987.R0JZ09"/>
    <dbReference type="GeneID" id="19402589"/>
    <dbReference type="eggNOG" id="ENOG502QQSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004282_4_0_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA82679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="503" mass="56714" checksum="6E61C67559DB2D23" modified="2013-06-26" version="1">MVRLWTGTGAVLVQTLYWYKMAGGLKTIDDYVELYNGQWQESAPRGLYPGVLTNYTDDLSFSMTQLSENPYRIFRVPKDTKLPFTVSNTSAIAGQSLESLQSSGRLFLTDFLDQKYQLMSPGKYGAACQAYFYIDPISQDFLPLAIKPNLEGSELVYTPQDLDNDWLLAKMMFNLNSLWYTQWYHLAATHAVSEIVYLSAIRTLSDEHPIMAILHRLMKDAWAFRPVAVERLTYPGGPIDKLFPWTGAQAANYTHALYQSGEASAFQANYFGPNLEKRGLINSTSGPKIKAFPFYQDACVINAEIRRFMETLVNSYYKDAIDITNDSELQAWIKEAIPAQIVDFPSSIDNAGTIIDILTHIAHLVSIVHGTLNSNALFASSGSLPFHPFAFYSPLPTTKVIMDIMQFMPPVEASLGQIALTGNFNRPSFVSSNETMVHMFDDRVMLSKMNKDVEKAERLFRDAMKRHSNVVRGRNFGRDQLCGGMTYCWTTLDPDTASYWLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZV3</accession>
    <name>R0JZV3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_98903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031100.1">
        <property type="nucleotide sequence ID" value="XM_008032909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZV3"/>
    <dbReference type="GeneID" id="19406401"/>
    <dbReference type="HOGENOM" id="CLU_013929_17_1_1"/>
    <dbReference type="OrthoDB" id="3942738at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA81717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="149" mass="17482" checksum="D5E2030ED6A8AD51" modified="2013-06-26" version="1">MTAIEKALAAINSQGLEGQISYRTAAKIYGVAASTLTRRHQNKTRSRAAAARPRRLLSPQQEKYLVQHIEKLSKRSTPPSQEMIKKYVANIAKRQLSNSWFTRFLWRNREKIITRNTAGIDQNCKKANDFKDYYNYFRLLYDYIEKYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0K212</accession>
    <name>R0K212_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_163200</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025646.1">
        <property type="nucleotide sequence ID" value="XM_008027455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K212"/>
    <dbReference type="STRING" id="671987.R0K212"/>
    <dbReference type="GeneID" id="19398684"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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            <end position="40"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="104"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA84189.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="199" mass="21805" checksum="DD5A4F5D0BC35DFE" modified="2013-06-26" version="1">MAIFDLRKNLIFYGAYHRDPTNVAIHMTCVPLILGTAFLFGTHTPALPLKPHALLTRLHLPLNLGTLAAATYSTLYVLLSPNVAGVAATPLVMGLASASNYLCTRFNKTKVTAGAVALHTISWILQFVGHGKYEGRKPALLDNLAQALFLAPLFVWYEVLFRLGFYKELHADIMRGVEEEVARMEARKGKGAVKGKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>R0K4M2</accession>
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        <recommendedName>
            <fullName evidence="15">Leptomycin B resistance protein pmd1</fullName>
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    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_108583</name>
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    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA88013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008026314.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19395312"/>
    <dbReference type="eggNOG" id="KOG0055">
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    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000967">
        <property type="entry name" value="ABC multidrug transporter mdr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="96"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="147"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="324"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="835"/>
            <end position="859"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="76"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="401"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="724"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA88013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1287" mass="140223" checksum="AD98C087F7CEFB9D" modified="2013-06-26" version="1"> </sequence>
</entry>
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    <accession>R0K561</accession>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">28A</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
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    <dbReference type="eggNOG" id="KOG1715">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="50S ribosomal protein L7/L12"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="97"/>
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    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
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            <end position="182"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16320"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA83507.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="183" mass="19477" checksum="7582C45A062F0008" modified="2013-06-26" version="1">MAAPASRALRRCICTAKQTAYVRPTIGATQQRIQRRWQSDSAAPTNPKIATIVDQISQLTLLETADLVSTLKTRLNIPDMPMGGFVTGPGGAGPAAAAAPVEEEEAAPAAQEKTLFNVKLEKFDPAAKPKVIKEVKAMLGLSLVDSKKFVESAPKVMKEGVPKEEAEKIVETLKALGATVVLE</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908833">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K5K3"/>
    <dbReference type="GeneID" id="19404845"/>
    <dbReference type="eggNOG" id="ENOG502SR2P">
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    <dbReference type="OrthoDB" id="5430532at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="344" mass="38449" checksum="F605252470EADE38" modified="2013-06-26" version="1">MARKLSFNLAPVKMAPKSDLGDRASDPASSHSRESSSHRRHTSKDTICDNSPWINRRVLDSHTELELRAACRLILKNFKPSDYGMENTDPKLDFAGFKPRKESKPLPADVNVRIPTGAPPEPASSTSFLPRSRSTKTRTRAKADMEIRARQNADAPARANSSRKRADFGWFTDRDAEKDEKLRTLGKASMDVARPAAATNISDEDVTLPVAVTSTLANQKPSHHLDDPVAAADAQATEWMRRELDKKQQQQQQQQQDTTDRRRPSMSAARPPSRTASIKESVKEYVFPGSRSRALSRAQSKDSLRSSVENQENGLSRQGSNAGWRNWGLRRMKSERDAGCGMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6G9</accession>
    <name>R0K6G9_EXST2</name>
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        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_164280</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="496" mass="54069" checksum="E9239550FBAA2942" modified="2013-06-26" version="1">MDTTFITIHDLSDDAHILYSSDSIVDILGHTPDEVVNRSVWHFFHPDELPLAKAQHSRGVRLDKAAVLSYCRLKNRQGEWVGCECCFSIVYDVLVCCTSVYRQGMQSQKRAVEAPIVRKLFASSPKDPRYHMLSHLSTKFDLGHEDQTHEPRAALFLNRFTRTLTVMYATSGIEQIIGISGEAMKGRSFYYCIAPNCLEDAVRCLESAKGNDSIAYMRFFFRDPRQDDAPEATSSESEDDVMTDVTGSDDDSEGGVGLGVPPASEGASPRQLSNPNHSANHSAEPSASRSHSREHPSYRSNTHQAMFGGSGPRSSISSASSPRSEARDDQIELEAVISCTSDGLVVCLRRARPMLPGALPTAQPTQQYNGIFAAPWATQPVFHPAPPQMPQYPLGARHPAMAQAAPSLEFQNNFMRSIRDVAVFAWALTGINGSLVDYARGKPVGESQPPEGFPIWNPLPDPAFIGGKQHSAAPSGYVSGSTSSSSNDPFGDPGLH</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343128" evidence="1">
        <location>
            <begin position="17"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88653.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="293" mass="33344" checksum="E031423ADFB8030E" modified="2013-06-26" version="1">MLFLLLYLLFGFSVCGTPLAPEGEPDFSLYFDRSEIDPYMRNEDGEHALHQAVTRRLDDHFRTDEAAHALHVRGLNNKRASAKVTVYYRPNLNDVCIENGLRRVHAAAYVNVCINPRQFSVICDIDEEHDEAPIVYGNCSPGYFCVTVLKDTLTVVDPANLHIGQAVEPICTQEVKLDIFKITESLLGFVSEWWRAPGKFKVFFGRMALQGQTLGTAYNLRWDWKTINSKFGTQAGFKRISDTSSATHHEYEMSYDYNYRGDMQFRAAVDWKEPLGHLGVLTLLVYFAAISPK</sequence>
</entry>
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            <fullName evidence="1">NodB homology domain-containing protein</fullName>
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    </protein>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
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        <property type="nucleotide sequence ID" value="XM_008025237.1"/>
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    <dbReference type="eggNOG" id="ENOG502QU9T">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
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    </dbReference>
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        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
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            <begin position="29"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="327" mass="37615" checksum="7827AFBED75C7F47" modified="2013-06-26" version="1">MGKKRVLVSYGVDIDAVAGWLGSYGGEDSTSDISRGLWAGTIGTQRLLKLFDKYNIKATWFIPGHSLDTFPEDCAAVRDAGHEIGLHGYSHENPADMTFEQQRDVLDKTYKQLTAFCNGKPPRGSVAPWWETSAEGTELLLSYGIEYDHSMSHEDHRCYWLRTGDQWTKIDYTKKAEEWMKPLIKGKETGLVEIPGSWYIDDLPPMMFMKKSANSHGWVNPRDVEQIWMDHFDYFYREYDEFVFPMTIHPDVSGRPHVVLMHERIIEHINKHEGVEWVTMEQMADDFKKNNKVPEGAMMPAPRGEILKLQKEGKAYSLVDYDGPMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6Y4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_20816</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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    <sequence length="410" mass="46938" checksum="5FCA8F9257012845" modified="2013-06-26" version="1">MSNLSNDSSAQTGHVPPREEVHHQALLRMRNLHDMRKFTQENNKTEGMLWTSTTQLRNLERQCFPHRAHGLRLANMTDEDTVQEAQAAQKWLFGILEYHNRVMMPQQDLGTFTLAVGKQMRGQQQNWTEKERLYMALTDHELPSPKDRLQAAFMIVLHLNLAKNLSDISSIAKTHSERLQRRAEIESKFLHTLEKISERVESILIDQFACAIPLSHTAGPGNGTGAIDGDSGYCPICQNSYSAFSEFSIDELVADYPVRIKYCGHIVGKACLEQWLMTPKIDEAKYPYRTCPLCRVQVEGVKYPSVPRGLTNHVNKDRRSLEVCRELVYGFGLDPEECLLAIVACMSEEIACTELLHEIERRGGNKAHEHALKKKLEDLRMEKWAWGFRGNGVWDVLRREWMTSGVVHRV</sequence>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57042" checksum="61BDCE27E489720A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0K992</accession>
    <name>R0K992_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_169381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008028101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K992"/>
    <dbReference type="SMR" id="R0K992"/>
    <dbReference type="STRING" id="671987.R0K992"/>
    <dbReference type="GeneID" id="19400886"/>
    <dbReference type="eggNOG" id="KOG3458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="276296at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="11">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA86009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="154" mass="17621" checksum="3690E3F34559EB6E" modified="2013-06-26" version="1">MSSRQPRFNQQALIDTTPLPDDIPKVQELGASSAPLLSASYFIGARCKAYNDDYMMCKTEANGRGEFECMKEGRKVTRCAASVIKDINENCLTQFRTHWQCLENHNQQLWNCRSAERKLNQCVFEKLKLEKTIPDTPKGETPVHLRTRNIFAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>R0KA37</accession>
    <name>R0KA37_EXST2</name>
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        <recommendedName>
            <fullName evidence="20">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_91078</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008029367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KA37"/>
    <dbReference type="STRING" id="671987.R0KA37"/>
    <dbReference type="GeneID" id="19405878"/>
    <dbReference type="eggNOG" id="KOG1142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276221_0_0_1"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA85422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027818.1">
        <property type="nucleotide sequence ID" value="XM_008029627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAZ6"/>
    <dbReference type="STRING" id="671987.R0KAZ6"/>
    <dbReference type="GeneID" id="19397464"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA85422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="487" mass="54543" checksum="D1CF51005CA25F37" modified="2013-06-26" version="1">MSNLPKWLLAVCALISYLLLRAIYRLTLHPLKSFPGPASRAISHVPHARSILSGYLPHDLTSLHAKYGDVVRISPDMVSFISPEAWTDIYGHGPNRNFPKWGMTRSHKTVDHLLSANNADHARQRRTVNHAFSDKALRAQEELVMRYIDQFMNALAAQSGADVNVKNWLEYTAFDIVGDLAFGEPFGCLSNGAYHPWVGLLFPFIKALSLFGAARLFKPFTPFLIALLPKEDIRARMQHIKLSAEKVHKRLAAGEQPHRSDFWTYILRHNDEKGMCIEEMESNASLFITGGSETVATALCGILYLLAKNPASMQKLREEIFAAFETKQDINMLSVGGLKVLQATINEGMRIYPPVPAGLQRIVPKGGAIIAGHAVTEGTIVNVSQQPAYHLASNFAQPDRFAPVRWLADASAEYSQDKKDVFQPFSTGPRNCVGKNLAMAEMKLILARLVWQFDWELADDAFALEKQRVFIMREKPDLNLRIKIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBW9</accession>
    <name>R0KBW9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_153664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025458.1">
        <property type="nucleotide sequence ID" value="XM_008027267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBW9"/>
    <dbReference type="STRING" id="671987.R0KBW9"/>
    <dbReference type="GeneID" id="19397323"/>
    <dbReference type="eggNOG" id="ENOG502SNI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_5_1"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA86894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="416" mass="46398" checksum="F05E354D16E5F72C" modified="2013-06-26" version="1">MAYRLLVARQESGPPPSPEYMAENQGPNLMAVEGPLFALSTTAVLLRFYVRVFMLKTFGWDDLMMLIAVAISTTTLGLFLTVIDLGLGRHVEAFPPENIFPFFMYMYFYSILIISAYSFIKLSICLFLLRLADRTKWRPFLIGMLVFLVVFTIGSTFAIIFQCIPVRAGWDFNLRPPTGDAKCYDPTIFKNVGVFNSSVNIATDLIFALIPIPMVWKLQVTLRTRIGLAAILSLGLFASGVAIYKTPMQANFFKVKDWSGDGSWYYIWQQVEMHVGIIAACLPTMKPLLSNVFGQVRSMATRGRTTGSNGINSTPFRSNGYVKQNESSTGNSYAMKNMSEASQSTGRDPYDEDAVLGKDMSYTVEAGRGKTDFRRSIIGGRQSDDSILSYEGGCGPRRPIPRGMAIVRTTEVDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCI1</accession>
    <name>R0KCI1_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_169496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026482.1">
        <property type="nucleotide sequence ID" value="XM_008028291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCI1"/>
    <dbReference type="GeneID" id="19400925"/>
    <dbReference type="HOGENOM" id="CLU_2456190_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA85917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="89" mass="10269" checksum="44F7AD13F08FA002" modified="2013-06-26" version="1">MRDREEYHSDAEPHQTWPLLATPQTAARKPIFGHHDPLAREQSCKMRAVHPHYTPHQSIRSHPRRGTRASDHSRESANRSYHHCDSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KCZ3</accession>
    <name>R0KCZ3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine decarboxylase-like protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_169419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908615">
        <property type="protein sequence ID" value="EOA86052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026328.1">
        <property type="nucleotide sequence ID" value="XM_008028137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KCZ3"/>
    <dbReference type="STRING" id="671987.R0KCZ3"/>
    <dbReference type="GeneID" id="19400899"/>
    <dbReference type="eggNOG" id="ENOG502QSR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_1_0_1"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA86052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="23832" checksum="C18C11014C444A4B" modified="2013-06-26" version="1">MDATTDNGTANQPVVCVFCGASSGTSPVHMEAARALAHALHKSNTKLVYGGGTVGLMGEVARTLVSLSGPDSVHGIIPAALARLEQNYDPTNPASHAVSETIYGRTTVVKDMHTRKQMMAQEVTKGGPGGGFVALSGGYGTFEELMEITTWNQLGIHSMPVVVFNVDGYWTGLIEWVKNAVRSGFVAPTNAGILSEALTADEVMTCLKEYENAPGRFNLTWEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDE4</accession>
    <name>R0KDE4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_169281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026171.1">
        <property type="nucleotide sequence ID" value="XM_008027980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDE4"/>
    <dbReference type="GeneID" id="19400852"/>
    <dbReference type="HOGENOM" id="CLU_1817000_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343245" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="142" mass="14113" checksum="D391421F78685353" modified="2013-06-26" version="1">MRFSIIVSALAAMIPAALAESSATGSMVPMMSPTAPPVTMAWSGEASTTAGGSMAMATGKSSMMGSGMKESGMMKSGMMMESGMKETGMMKETGMSGMTMSEGMPKTTGSAMSAMAGMSGSASSMELSTGAVLTAALLLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0KDL3</accession>
    <name>R0KDL3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_39735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026116.1">
        <property type="nucleotide sequence ID" value="XM_008027925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KDL3"/>
    <dbReference type="GeneID" id="19404515"/>
    <dbReference type="HOGENOM" id="CLU_180248_0_0_1"/>
    <dbReference type="OrthoDB" id="3684436at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354150" evidence="1">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA86247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="101" mass="11011" checksum="6067D763CE43AA8B" modified="2013-06-26" version="1">MNLLTHALNLLISAILLASVLASLNPSSPALKLNLSPRDMLCEICIERYDFCVENGHTKGQAGCKETCAEHVCHVQRRRGVECSKCGDAFAVCGETSRYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0KEF5</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S6KJ">
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA87699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="393" mass="43093" checksum="5A76141987E449B3" modified="2013-06-26" version="1">MAYVAPYPLLNRTYSLYRLSPLHHGDAPLLVDDATRTHAKRLKDQLKGDNVRGVQVDFAAAQETATLGPLDDCRWEVLGDEDAWIDRRLQSEDPGAPRVAPDVTPDRARGLHVTLDYDKQQYNALLLRDPDATSSPIGFTALPLLLVKMPAPIRDIFFSYLRTTFDAHVAPLRLPSPFLTSALETFFTHLTASSSTLSIQHVIKQLHIQLAFPTATSLLKHIQVSIAAEDVAEFVRRGRLLKDTHSKPFTAALTKYLNQHLALDLSHPKVHVSRISCSSFHLGTERLKIVAPDTLPDASFSDQESSQDSSAAQLAVHELYTSLVREATGSGKFLPEDLAKDSTDDSPSSTASARRKRAISTTAVSNGNSKKTKARGKENAARVSGDNTVIVDS</sequence>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_149972</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908559">
        <property type="protein sequence ID" value="EOA87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008026231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KEZ8"/>
    <dbReference type="STRING" id="671987.R0KEZ8"/>
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    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
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        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
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    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
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    </dbReference>
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        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354175" description="Oxidoreductase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
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            <begin position="9"/>
            <end position="138"/>
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    <feature type="domain" description="Gal80p-like C-terminal" evidence="3">
        <location>
            <begin position="145"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA87894.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="386" mass="41615" checksum="A74A9263FFE544A3" modified="2013-06-26" version="1">MPSNSLPLRTALIGLSSSAVTSWAAAAHLPGLFTPTGRSKITITALLNSSVDAAKSAIDQFKLPTTTKAYGSAEDLAADADIDLVICNTRVDRHYETILPSVKAGKDVYVEWPIAANKEQIDEIVEAATKSRSRVAVGLQRRWAPQVIKLREILDGGNGDLGKVLSSTVQAFGGTIERAILPTGLAYFTDKKVGGNPIAIGVGHVLDFVLSTLGNLDPSTLHSKAQIQRPDIPIRNPSTQEIVEHKTSDVPDLLSFHGALAPSPQTAADATLSFHFRRGQPFPGTPALTWTINCEHGEIKLTSANSMVLPASERDGPVTIQVHDYKTNEVKDVAWDWTPDQKEVPIVARDVMWCLYAFADGKAEGDGWVGLQDAAQYAKLMDSFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="9">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908481">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
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    </dbReference>
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        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA91833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="69918" checksum="1270080D35BABA0B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0KGF8</accession>
    <name>R0KGF8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_38427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008025542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KGF8"/>
    <dbReference type="STRING" id="671987.R0KGF8"/>
    <dbReference type="GeneID" id="19404351"/>
    <dbReference type="HOGENOM" id="CLU_2086282_0_0_1"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="117" mass="13694" checksum="A8754620AF5762E5" modified="2013-06-26" version="1">MYVYKFNALTNYSKVSQCNSTRDELGFKNLIIAKRMCTGGEKVRESPFVDPAELDSFQKANYPGYYWWVVFHKLLRHGIGRMVVEDSEGNFDFDIYSPLASKPITTWYNWDRNEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KH74</accession>
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        <recommendedName>
            <fullName evidence="5">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_88321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025830.1">
        <property type="nucleotide sequence ID" value="XM_008027639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KH74"/>
    <dbReference type="STRING" id="671987.R0KH74"/>
    <dbReference type="GeneID" id="19405698"/>
    <dbReference type="eggNOG" id="ENOG502SY5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168441_3_2_1"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA87422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8574" checksum="C8564CC4C4FB51A7" modified="2013-06-26" version="1">MTTPQPLGDRSQSDSASVSSNNPEASGELTAVVDDLLNQLNTKFNSISSELLSKMDDMSRRLDNLEATIQGGDGTKGSGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0KHK3</accession>
    <name>R0KHK3_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_26754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023274.1">
        <property type="nucleotide sequence ID" value="XM_008025083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KHK3"/>
    <dbReference type="STRING" id="671987.R0KHK3"/>
    <dbReference type="GeneID" id="19403053"/>
    <dbReference type="eggNOG" id="ENOG502TGHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103817_0_0_1"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="187" mass="20185" checksum="877EE186AAC2AC58" modified="2013-06-26" version="1">MTTPTTTAAPPSLMITSTRAASSTTRCASSNIDFSVSLAEPPYKTVTEHESETTAPAGTAPARTDSGDSVPVAAIVGATLGGVILCALLMTVFLCIRKRQAKKVYKAPAYPSPLVGSDMTRQLSSKSSSQFQQKVAALYRADSIERYEPPQLDSLQMTRKDQGQDLNLDDHLDHHDVHKLQPFPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0KI16</accession>
    <name>R0KI16_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SETTUDRAFT_168107</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the large ribosomal subunit. Interacts with DHX33.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023525.1">
        <property type="nucleotide sequence ID" value="XM_008025334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KI16"/>
    <dbReference type="STRING" id="671987.R0KI16"/>
    <dbReference type="GeneID" id="19400426"/>
    <dbReference type="eggNOG" id="KOG0746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_1_1"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 17" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EOA88874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="392" mass="44397" checksum="6DF62525BCE6E692" modified="2013-06-26" version="1">MSHRKFEAPRHGSLAFLPRKRAARHRGKVKSFPKDDPKKPVHLTAAMGYKAGMTTIVRDLDRPGAKLHKKEIVEACTVIETPPMIAVGLVGYIETPRGLRSLTTVWAEHLSDEVKRRFYRNWYKSKKKAFTKYAKKHSENNGQSITRELERMKKYCSVVRVLAHTQISKTPLQQKKAHLMEIQVNGGSVADKVEFGHGLFEKPIEITSIFEDNEMIDVIAVTKGKGFNGVTSRWGTKKLPRKTHKGLRKVACIGAWHPAHVQWTVARAGQDGYHHRTSVNHKIYRIGKGDDEGNASTDFDVSKKRITPMGGFVRYGEVKNDFILLKGACPGVKKRVMTLRKSMFTHTSRRALEKVELKWIDTSSKFGHGAYQTPAEKRQYEGVLKKDLQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0KI93</accession>
    <name>R0KI93_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_26993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        <recommendedName>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
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            <end position="32"/>
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    </feature>
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            <end position="720"/>
        </location>
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        <location>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87932.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024292.1">
        <property type="nucleotide sequence ID" value="XM_008026101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KJT7"/>
    <dbReference type="STRING" id="671987.R0KJT7"/>
    <dbReference type="ESTHER" id="sett2-r0kjt7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="19397033"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_3_1"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="84"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="192"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA88267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="570" mass="61440" checksum="CF75664F343212E8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>R0KMK8</accession>
    <name>R0KMK8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_167729</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="KB908515">
        <property type="protein sequence ID" value="EOA89157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023008.1">
        <property type="nucleotide sequence ID" value="XM_008024817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KMK8"/>
    <dbReference type="STRING" id="671987.R0KMK8"/>
    <dbReference type="GeneID" id="19400284"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="148"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA89157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="330" mass="34132" checksum="A941B2AE45458064" modified="2013-06-26" version="1">MVKAVVAGASGGIGQPLSLLLKNCQHVTELALYDVVNTPGVATDLSHISTPAVVTGYLPKDDGLKNALTGADVVVIPAGIPRKPGMTRDDLFKINAGIVQGLIEGVAQYCPKAFVLVISNPVNSTVPIAAEVLKKAGVFDPKKLFGVTTLDVVRAETFVAEITGEKNPGNLSIPVIGGHSGETIVPLFSQAKPSVTIPADKMDALVNRVQFGGDEVVKAKEGAGSATLSMAYAGYRFAEKVIKASKGEKGIVEPSFVYLPGVAGGDAIAKATGTEFFSVPIELGPSGAEKAIDVVSSANEHEKKLLKACYDGLKGNIAKGVEFVQSPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0KNE5</accession>
    <name>R0KNE5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_182228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021384.1">
        <property type="nucleotide sequence ID" value="XM_008023193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KNE5"/>
    <dbReference type="STRING" id="671987.R0KNE5"/>
    <dbReference type="GeneID" id="19401906"/>
    <dbReference type="eggNOG" id="KOG3308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058668_1_0_1"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050262">
        <property type="term" value="F:ribosylnicotinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046495">
        <property type="term" value="P:nicotinamide riboside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="247" mass="28002" checksum="BB91D0A1AC459596" modified="2013-06-26" version="1">MSSPLLVGISGPSSSGKTTLSRLLRDVFPPSKLFILHLDDFYLTDAQIPLKNGVQDWDCIESLNLPQLKQALGHIKEHGKSPEWLVSQEDQNSVGEHGVPPAEIDRLRGHVAKLLEDKPDWHGKRLCIVDGFLLFSEDMKDIRSMFDVRLFLRTSYQTAKRRREARSGYVTLEGFWQDPPGYVDQIVWPNYVQDHKFLFKNGDVDGELDGHVCKSAGIHGMPREAEENMTKCLSWAVGVLEHVLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPA4</accession>
    <name>R0KPA4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_24993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021225.1">
        <property type="nucleotide sequence ID" value="XM_008023034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KPA4"/>
    <dbReference type="GeneID" id="19402863"/>
    <dbReference type="eggNOG" id="ENOG502T6HT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824229_0_0_1"/>
    <dbReference type="OrthoDB" id="3724701at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="326" mass="37376" checksum="15FACEF5735E8B16" modified="2013-06-26" version="1">MSWEKTQHTALTLWDIDRVFQDAHEAYEQWQARHRHTRSKWICFGGKNRDDAVGRALSLGRQIQRIMESGKEAFGERFEEGDQKCNTILSAQLLRVQYEIRQPLYDSAFSSTPVTPIDDIITTAKSVRRACLTALRDQYARLETPILSPVLPPPRFKVEFCPFADQLRKDLKETKTSTLRAKKAQPHDKHDDREICPHCSACVSVATHSGLPASRCILFTSHIALDPDAKDDRATFACNSCYKTFDDSYAFLDHYFQKQIGSDKSCLKLSVSRSTSSWFLKEELIDVDPSVVEQCLKNCIARETMRSKQHKRRGSRITIREVLTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0KQT0</accession>
    <name>R0KQT0_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_25426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021828.1">
        <property type="nucleotide sequence ID" value="XM_008023637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KQT0"/>
    <dbReference type="GeneID" id="19402915"/>
    <dbReference type="HOGENOM" id="CLU_2723813_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343413" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA90142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="72" mass="7184" checksum="83E83A0FC60B3D9B" modified="2013-06-26" version="1">MQYSTFILTTLALFGAAVHGTASPDPLPVGILDPRDTIGGCCCNHFQSSTCACYYGAAAGSGSCGSTCAGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0KRP8</accession>
    <name>R0KRP8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidyl synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_167330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022323.1">
        <property type="nucleotide sequence ID" value="XM_008024132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KRP8"/>
    <dbReference type="STRING" id="671987.R0KRP8"/>
    <dbReference type="GeneID" id="19400136"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_3_1_1"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43264" checksum="0287ECD0194E74C4" modified="2013-06-26" version="1">MAPSKQHSEIATGFETARRHLEAIAPASPDLTPPETSVTDKYAFAFDIDGVLIRGGRPIPEAIEAMKMLNGENEYGIQVPYIFVTNGGGKTEAERCIQLSKQLEIEVSPGQFICGHTPMREMAEKYGTVLVVGGEGEKCRIVAEGYGFKDVVTPGDIIKDNQDTTPFRKLTEEEYRNSRTRNFAEVEIEAIFVFADSRDWASDQQIILDLLMSKKGRLGTRSENYDEGPPVFFSHNDVVWSASHDLTRIGMGALRVSLEAMFKAVTGRTLETTAFGKPQIGTFQFATRLLQEWRKDTHGIDSPPSTVYFVGDTPESDIRGTNEYNEQNPDANWYSILVKTGVFQDGTKPRFEPKATVNTVLDAVKHGMEREYKKALKESMIATKVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>R0KS32</accession>
    <name>R0KS32_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SETTUDRAFT_166572</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021400.1">
        <property type="nucleotide sequence ID" value="XM_008023209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KS32"/>
    <dbReference type="STRING" id="671987.R0KS32"/>
    <dbReference type="GeneID" id="19399849"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
        <property type="term" value="P:mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 22" id="KW-0931">ER-Golgi transport</keyword>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
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                <person name="Han J."/>
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                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908482">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KTU7"/>
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    <dbReference type="GeneID" id="19396804"/>
    <dbReference type="eggNOG" id="ENOG502SP07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="71600at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004344149" description="Tetraspanin Tsp3" evidence="3">
        <location>
            <begin position="25"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA91167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33178" checksum="F13EBC46EEE46BF2" modified="2013-06-26" version="1">MTYTRKQVITCVSLLYLLVATALAGYAASRANARSIPISDTLTAFTTALPIVSGLLLELGYDLTRRHERRHQLSRGEIQRPPLVIVANTLIFIYSTVVITLSATHVAPSSTIDCGLRERWQRLFRHKDATAIRQIQDAFNCCGLANSRDMAWPFPDRTHNAHACETTYNGRTSGCLGAWKAEEQKMAGLFMTVVAMVFIWQFSIIAIPIQKNSWLHRVAPARLSRMIADERNGDAEPRRAIDFIPAYNRYSDRVEEEAEEDGHAPSRAIEQGSHPAFPANVGREQQPSVENEWARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0KWM5</accession>
    <name>R0KWM5_EXST2</name>
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        <recommendedName>
            <fullName evidence="8">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_86470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EOA92097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020465.1">
        <property type="nucleotide sequence ID" value="XM_008022274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KWM5"/>
    <dbReference type="STRING" id="671987.R0KWM5"/>
    <dbReference type="GeneID" id="19405587"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA92097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28222" checksum="F24BBE6CC8E4336D" modified="2013-06-26" version="1">MSLQTAEQPNLIVSTTDDGIAILEMNRPRKRNALSQAFIDELTAALRHIDRTPTTFAVILTSSGPFSAGADLTELGALTTAEATRVGWLKDLDDAFSSFRKPILAAVRGFALGGGFELALMCDMIYASADARFGFPEITLGTLPGAGGTQRLTKTIGKQKAMELILTGTTTSATEMERLGVVNRVASSEEDVLEVAKTVARSIASFSAPAIGLAKQAVLAAETTTLKAGLEIERALYYSSFSLEDCREGVTAFKEKRKANVQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0I536</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008032962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I536"/>
    <dbReference type="GeneID" id="19402751"/>
    <dbReference type="eggNOG" id="ENOG502SSNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104465_1_0_1"/>
    <dbReference type="OrthoDB" id="5426872at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA80676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="195" mass="21477" checksum="EACA93940A13E45C" modified="2013-06-26" version="1">MLLQGHPPRRHISSAPVSLSAASALLDKYLEDSQTHAHLHPDALITPDGVTFNSQGGAMGNPLMHHLRRVAAGMRGEYRAPDKTLEAQEREQEQQQQRGAKSGVADEEWQDMAAYQAEQGVTEVGDVGERSNLVQEGGEEPEVQTKDARKRTKEQADDGQATASGGIDKEARKKAKKERDMQRKREKTTQANKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>R0I559</accession>
    <name>R0I559_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_174429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Han J."/>
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Bushley K.E."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Barry K.W."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028388.1">
        <property type="nucleotide sequence ID" value="XM_008030197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IF89"/>
    <dbReference type="STRING" id="671987.R0IF89"/>
    <dbReference type="GeneID" id="19401183"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF156">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51303" checksum="92702C5D09542458" modified="2013-06-26" version="1">MALQDLIVGVVGGHLMLTLTLGPILILFIRSVYRVYFHPLSHIPGPLLAKLTSLWLYYHAYVGDEASTIHKLHQQYGPYVRVSPTEVDLSDADGIPAIYVSKRGFPKANCYANFDIDGHKTLFSTTDTEYRSPRAKAVVPLFSTKALRENERAIWGCVDRMVDRLVEEAKTKRPVNVLNLTRSLAVDAVSTHLFRENYDGVSERGPVLSVSAFVDLFVAVGRFFYLPNLVFAWLEWAVTKLVPDREADDSMSLVDKFVGTVVSNTTSKSTTYPGRLLAIGLSDSEVRALVMHPEKYQRPKEEVAKNAALGADAQEAQALPYLNAVVKEGLRLSMANPTRLPHVVPAGGWNFKGTYFPAGTIIGCSAYELHFNPAVFPQPRVFSPERWLNPTEDMLKYWFAFGAGSRACIARNLATVELQFATERLGRSGILDGARIVQSEVDIYEWFNSKVKGGKIELVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGT9</accession>
    <name>R0IGT9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_119307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028569.1">
        <property type="nucleotide sequence ID" value="XM_008030378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGT9"/>
    <dbReference type="STRING" id="671987.R0IGT9"/>
    <dbReference type="GeneID" id="19395777"/>
    <dbReference type="eggNOG" id="ENOG502R41Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="314" mass="34662" checksum="DF1FAFB791173057" modified="2013-06-26" version="1">MVKIIFGGFGLSDQAYFNTPEVRSQVIDTLLSNGIKNIDTARIYPGSEEAIGKLEKRKEFTIDTKLPGGFGPGTATKDGAINDSQDSLKRLQLDQVDILYIHAPETSIPIEETLEGINEAYKKGVFRRFGLSNYAAEQVQQIYDICKAKGYPLPQVFQGNYNPVARHYEAQLFPTLRKLGIHFYAYSPLAGGFLTKTTADLDAGGGRFNKDALGGLYSKLYDHEPLRQALTKWNEIAEKEGVSKAELAYRWVAHHSALQGDDDGVIFGASKPAQVEQTAQGIKKGKLSDEAVKGIDEIWESVKSVAPVDNYHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHM2</accession>
    <name>R0IHM2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_20181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026872.1">
        <property type="nucleotide sequence ID" value="XM_008028681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHM2"/>
    <dbReference type="STRING" id="671987.R0IHM2"/>
    <dbReference type="GeneID" id="19402299"/>
    <dbReference type="eggNOG" id="ENOG502RH95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842166_0_0_1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="127"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA84650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="324" mass="36181" checksum="27690151F552AE4A" modified="2013-06-26" version="1">MFLTPVFATQMVHEPTFGAPKRDPSSPTAPSVLSSASSDASFGWRKRRDSTSSNVSVSTDASSVPSVQPSPRPKHRKTLSSSSITRRLLQKRKPEQPQRKSEPPPTSAPVLSPAPVAIPPSSPPASEEKSSDLVVRCRSDVYHVDRVIMCYHSRWFARVCAVVMSPKSSKGAIDLSADDPSAVAAMMQYCYQLDYVHQLSDFDSDVSEDATLPFHVKVYMLAERYGVAGLRALALQKFKQCVAIVLNEDGKEEQLLLAIRVMYAPDRRANADDLRRVVIKLCADHVQDFIHDTGKKMSLVYQSMEEYPDFRAELFEEMGSRWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0IJ38</accession>
    <name>R0IJ38_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_163739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027465.1">
        <property type="nucleotide sequence ID" value="XM_008029274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IJ38"/>
    <dbReference type="STRING" id="671987.R0IJ38"/>
    <dbReference type="GeneID" id="19398871"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031576_0_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA84961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="57167" checksum="9B168051DBDEBB43" modified="2013-06-26" version="1">MFVGAFAAVFGAVSFFVYLFTPPRNFPKNIPTIPFYYGLLPLFKDVDQAELYRQYLKEPLAKHGAVKLFFGGQWNILVTNPTYIGEVLKQEDIYAKSGNQVKIPHSVLAEYTGENIISAHGEKWRLYQRVIKPALQADQDSEDIWKNSRILADMFLSDTKNARGNGIPIYAPLHRYALANLSEVLYSSSFETLQHPDSPLHTLQTKIKPIIFHPIFMNFPFLDYLPLKIRKLGRMLSRQFRHTLRNAIIKGHTRHVCNENDSKNVACRLLGSHREGMLSDKDLDDNLVSTFLAGHENPQLALMSLMYLLGTHTQVQDAVRKEISSLFPANASPDYEPSYTDIHDLPLLTSVLYESLRMFPPISQLINRRTTTPIVLGNTVPIPAGVYVGYNAYSTNRDTEFWGPDAEAFRPERWGTTNEDIGKLYRRANSKSAFISFHGGRRACLGQKFAMQQLRITLVQLLRDVKWRVDDAWDGRMTPAGPLYPRGLKLKFERVNGQVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0ILX7</accession>
    <name>R0ILX7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_161751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908637">
        <property type="protein sequence ID" value="EOA85826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026609.1">
        <property type="nucleotide sequence ID" value="XM_008028418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ILX7"/>
    <dbReference type="STRING" id="671987.R0ILX7"/>
    <dbReference type="GeneID" id="19398196"/>
    <dbReference type="eggNOG" id="ENOG502QVX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037358_0_1_1"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004343196" description="PLC-like phosphodiesterase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Kosti I."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">28A</strain>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0IR58</accession>
    <name>R0IR58_EXST2</name>
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            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
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    </protein>
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        <name evidence="10" type="ORF">SETTUDRAFT_89018</name>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
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    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="2 9">Single-pass membrane protein</topology>
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        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
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        <property type="match status" value="1"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA87380.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="96" mass="10614" checksum="FC72ABDBFF6274D4" modified="2013-06-26" version="1">MAENNPQPVASISRTTRPMSEALLNEKWDRCLSSMLIRSGLGVSFGVVFSVLLFKRRAWPAFVGLGFGAGRAWEECDNSFKRASAPSKDGLRIIRP</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">SETTUDRAFT_31751</name>
    </gene>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S4RI">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="274" mass="31484" checksum="4E572E306F7ECD1F" modified="2013-06-26" version="1">MATVRTLMKMNPTFAELAVKHGTDKNREEKALVTRQGTTMEVGGHLYAPHYDFHFQPLRDRDITLFEIGVGGFDDRQAGGESLRMWKEYFLKAQIISLDYYDKTALQEDRIRIYQGSQDDPNILHKIHKEHGDFDIIIDDGSHLCQHVIASFKILFPLLKIGGMYVVEDLETSYWKVTGGSSTDLNTTKSSMGFFKSLLDGLNHVEFELPGYMPTYFDKHIVSMTFYHNMVVIYKGENNEQSNVMVDNQMPPALAELWPKFDWVKEAEVTPSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>R0ISV5</accession>
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        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_83488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908570">
        <property type="protein sequence ID" value="EOA87711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024573.1">
        <property type="nucleotide sequence ID" value="XM_008026382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ISV5"/>
    <dbReference type="GeneID" id="19405461"/>
    <dbReference type="eggNOG" id="ENOG502S41B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061199_0_1_1"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA87711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29382" checksum="11AB2EB345BFFE4D" modified="2013-06-26" version="1" fragment="single">MASPRLIDRDERTRKKPMRVLVLGMCRTGTTSMAVALRKLGYTPHQMRDVLTKPSEIELWQEAVDVTLLPPQDRVAYQRNQAPYGKEEFDKLLGEYDVVTDLPSCVFAKELVDAYPEAKVILTNRKYDDWEHSMQESIWCLDTWRLFILCRQLGVTQLSALMHLIHSIFKAHNNNTYGGPRAKSAFEKHYDTVRRSVPKDRLLEVDTDAELGWEPLCNFLGTEIPKESFPKVKEEQAMRKGLDKAWWGMVQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0ITQ8</accession>
    <name>R0ITQ8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_107792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024224.1">
        <property type="nucleotide sequence ID" value="XM_008026033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ITQ8"/>
    <dbReference type="STRING" id="671987.R0ITQ8"/>
    <dbReference type="GeneID" id="19395256"/>
    <dbReference type="HOGENOM" id="CLU_013929_17_3_1"/>
    <dbReference type="OrthoDB" id="3942738at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA88155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10267" checksum="F49E1FEEBD10D7F7" modified="2013-06-26" version="1">MTPIEKALAAVDAQDPKERLSYRAAAKKFSVVLSTLTRRHHKQTQSCAAAAENTKLLTTQHEAELVKYIQKLSSCGLGLTRSIIKNFVLNIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0IU91</accession>
    <name>R0IU91_EXST2</name>
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        <recommendedName>
            <fullName evidence="15">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
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    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_46943</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024131.1">
        <property type="nucleotide sequence ID" value="XM_008025940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IU91"/>
    <dbReference type="STRING" id="671987.R0IU91"/>
    <dbReference type="GeneID" id="19405096"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
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    <dbReference type="PANTHER" id="PTHR45618">
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    <dbReference type="SUPFAM" id="SSF103506">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="146"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="336" mass="36142" checksum="5446E1FA45F6A515" modified="2013-06-26" version="1">MPAARALENAKQSSETVFSDASSAMSKAAENPKKATADFFHTPFMRAALPFINGGLAGMTATTVIQPVDMVKVRLQLAGEGVKTGPKPTPITVFRDIVSQGKVLDLYTGLSAGLLRQAVYTTARLGFFDTFMKSLSARAKENGTTIGFKERAGAGLAAGGLAAMVGNPADLALIRMQSDGLKPAAQRANYTSVIDALVRISKAEGVTRLWAGSYPTVVRAMALNFGQLAFFSEAKQQLQSTSLSSRSQTLTASAIAGFFASFLSLPFDFMKTRLQKQTRAPDGSLPYKGMFDCFKKVAKEEGLMRFYRGFGTYYVRIAPHAMVTLIVADYLGFITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
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        <location>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA88450.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="501" mass="54843" checksum="D97C6EF899EFA2A1" modified="2013-06-26" version="1" fragment="single">TFHGPWSKSLSAFKKSVESMPSQYKPAFDSASKATLDKICNPEVLHVWESDSDIDSLLQLTSVIAKLCDLGVRQNKGANASDGSMLIIAEESGSRNNFSRICMLVEYLTGAEAKRHLDGTVAVYSKIVVVRGWDNSVLSGQKEALDKTAKRINTALERVLKMGGFHGDSKKVVWHHNAVIPFLLHWINTTTPALRAALSAITVTGSLDFTAGIAPSAAGRANKLAHLERLEQYAKKLDVPVVFVDSASQLISFAYLGTYMYYHAYYINTLLPPALSRPHLHKAQDELLAFAFRLRAASDHQYGGAAVKMVQRHLDARIAKPWARLCITNETYDKQACRAAAKDNAIHHAVQLADHPFALLSHKPSPSPSKTNNTIPAFARLALGPASASPHTTYTAAPITFSFRTSQLRPASPATLHLLIPQPGVDTDKITSHIQGLMMAVLERVRQEKGNPVLAEPESNMWRAVVTACTWALEAKLPAEVQAKVRFVRDKLKGGTWGFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2098341_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88560.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="116" mass="12000" checksum="6EBD18DD5413A2E8" modified="2013-06-26" version="1">MAWSSKQASKPCMQSSLSGNWGLGNVDGKQASTCAWALFGGGNFFGGLQDAGECISQAASHDDDDDDEGQWGRSVQFGKAIGCMHACICSLPAVLSGVGSSSPDDDDDDDDEEEAS</sequence>
</entry>
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    <accession>R0IUX6</accession>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023860.1">
        <property type="nucleotide sequence ID" value="XM_008025669.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IUX6"/>
    <dbReference type="GeneID" id="19402004"/>
    <dbReference type="eggNOG" id="KOG1922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="150"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1445"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="858"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1408"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1555"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1295"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="875"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="922"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="970"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1408"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1426"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1462"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1472"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1503"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1516"/>
            <end position="1530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA88441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1673" mass="184813" checksum="1FFA1F519BB4DC47" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0IW47</accession>
    <name>R0IW47_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Actin cytoskeleton-regulatory complex protein sla1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SETTUDRAFT_38158</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908526">
        <property type="protein sequence ID" value="EOA88841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023330.1">
        <property type="nucleotide sequence ID" value="XM_008025139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IW47"/>
    <dbReference type="STRING" id="671987.R0IW47"/>
    <dbReference type="GeneID" id="19404331"/>
    <dbReference type="eggNOG" id="ENOG502QQC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2209857_0_0_1"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000300">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
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        <location>
            <begin position="2"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
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    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR036396">
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    <dbReference type="PANTHER" id="PTHR24287">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
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        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
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    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008021512.1">
        <property type="nucleotide sequence ID" value="XM_008023321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J1X3"/>
    <dbReference type="STRING" id="671987.R0J1X3"/>
    <dbReference type="GeneID" id="19394873"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_1"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000007">
        <property type="entry name" value="Lysosomal beta glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000009">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF117">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="10">
        <location>
            <begin position="707"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA90761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="788" mass="85550" checksum="7F13E8B4587A5751" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0J3D7</accession>
    <name>R0J3D7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_49510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA91246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020317.1">
        <property type="nucleotide sequence ID" value="XM_008022126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J3D7"/>
    <dbReference type="STRING" id="671987.R0J3D7"/>
    <dbReference type="GeneID" id="19405174"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021925_0_0_1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="351"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA91246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="9">Component of the Mediator complex.</text>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="KB908481">
        <property type="protein sequence ID" value="EOA92241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008020496.1">
        <property type="nucleotide sequence ID" value="XM_008022305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J6C3"/>
    <dbReference type="STRING" id="671987.R0J6C3"/>
    <dbReference type="GeneID" id="19405618"/>
    <dbReference type="eggNOG" id="KOG2804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_5_1_1"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="129"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="398"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA92241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="441" mass="49160" checksum="142653F15D195056" modified="2013-06-26" version="1">MPPKRKRTTAVDSVKQEAMDPVQPSLRDASDEGAEDPVLQAVASKKERQADANGSTKRVRVAKGPHDEDGDEERAVKKSRRTPSPVDDEHGEAGEAESMRMPPPPKAGLVDPVGYKTNPPPVGRPVRVYADGVFDLFHIGHMRALQQAKTAFPNVHLVVGVTGNKETHKRKGLTVLSARERAESVRHCKWVDEVIEDCPWIVTAEFLLKHNIDYVAHDDLPYGADEGDDIYGPIKERGMFLVTQRTEGLSTTGIITKIVRDYDQYIDRQLKRGTSRKELNVSWLKKNELDIKRTMAELRDSIKANWTTTGQELSKDFRQFWQSSRPASPARTPTREQSQAEAMDQSGAARSPSALSRLSYLDILRANNSRESSEFTAGYNLGLIGGVRAWMARSRRNLNDSRPQSPMDDSSDEHEGKSLQEAPRGRTGKQTKSEPPMETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>R0JIK7</accession>
    <name>R0JIK7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SETTUDRAFT_36036</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031275.1">
        <property type="nucleotide sequence ID" value="XM_008033084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JIK7"/>
    <dbReference type="STRING" id="671987.R0JIK7"/>
    <dbReference type="GeneID" id="19404081"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_3_1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001834">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="33"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="260"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EOA81163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="485" mass="54789" checksum="2435B18E22FA312C" modified="2013-06-26" version="1">MPGPRKRPYSNIDFTLRKVFKKAAFRPPQREIVLATLEGQDVFVQAATSFGKSLCYQLPAVVDFGITIVISPLLALMNNQVASLRNANIRVETINSTTPTADRNRIIADLQCGHPLTRLLYVTPEFCQGDHFRRILRIIHSQRELARIAVDEAHCVSEWGHDFRPSFQQLSFFKTEFPDVPVICLTATATARVRDDIISTLALDPKKVAMFRMSSSRPNLHYEVRFKSDEEDHYDDFVALLRAIYARRADRPERASQLASQNQRTDNVPGIIYTLFRKDCESLAARLRSDGIGAKPYHAGLSVSERADALSGWIANKAGYDIIVATTAFGMGIDKENVRFVVHWQIPKSFEGFYQEAGRAGRDGKASLCILYYGREDRDRAASLMSRDALRQPPRGAGAEAQQQQLMNRARSLQALVGYCEATDKCRHKLIAKYFADEGPTPCDFACDWCKDAEALVKRKERGLASEEWCSTQRAEGRYDIDEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0JJ82</accession>
    <name>R0JJ82_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_142871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030882.1">
        <property type="nucleotide sequence ID" value="XM_008032691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JJ82"/>
    <dbReference type="STRING" id="671987.R0JJ82"/>
    <dbReference type="GeneID" id="19396692"/>
    <dbReference type="eggNOG" id="ENOG502RXN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035149_0_1_1"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA81403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44597" checksum="64E41EE973FCA2A1" modified="2013-06-26" version="1">MRRPPEPHYSFTIPSVHDDTPLDCRIYLPHVLLRPDDPEDIAKWKRRGIVMAHPYAPMGGSYDDRVVGIVIDEFLHAGFIVGAFNFRGAHGSKGRTSWSGRPELDDYTSFAAFFMHYLSSLQPHLAHQLLCVSERPQMLQSPADPVSTPGNACPIVVLGGYSYGSLILRHLPPVPTILKPFAAPEAGSAADEIVLRSHKLADQTNMEWVALTRDETRARKPKAKQTARPSITMGGEETSPGKRRSSREIRRSFEGTRLEIRSKLRRLSHGKREKSEPTTPPPAVKSEDFAMPDTRYLLISPLTTPISSLAAPALIHRLWGKSKDDGHEIVGKHMCLAIYGNQDIFSSAKKLREWAERLKDAPASRFYSVEVEGAGHFWVEHGVETRLRVALEQWAMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>R0JNS1</accession>
    <name>R0JNS1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_181005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029857.1">
        <property type="nucleotide sequence ID" value="XM_008031666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JNS1"/>
    <dbReference type="STRING" id="671987.R0JNS1"/>
    <dbReference type="GeneID" id="19401814"/>
    <dbReference type="eggNOG" id="KOG0995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012583_0_0_1"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="127"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="348"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="575"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA81949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0JWS1"/>
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    <dbReference type="eggNOG" id="ENOG502SUCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA81949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="502" mass="54353" checksum="29CFF897F946F500" modified="2013-06-26" version="1">MLPPSIQTFTPHQLPLQEMEDITVVPETTMAATSSNGDPKPRKMRASCDACSRAKVKCDKVRPTCQRCGNMNVCCNYSPSMRLGKPRKHRNPDGTLKREVSPAGSYGPLGARFDLIPRTAASHTYESSPEPTDPFYFGPSTPEFQYQDAFVGNNFSGSRSPACSEGTVSLVGAWSNDEQIMFGNPADMFVQMPHYLPQQTPVHGHIRSTSTQSQPELYASLDSQHPSPDSRPQLLDMQQNMYLPQEKTADSPSPMLSAPLPTPPASSSLPTHDCTLSAFQTLNSLYAPSGALTPGGSPTLECILSTNKAAVDTLYALLNCDCTSTPHFSSTINLAIMKILSWHQAIARAHDPRGLFSPHLDTHTEVYTAPPPAPPSHHASPDTTTSSDTECARRTNLVLSELCRIEKLIDRFAERYCQYMTGGSNAAAKPDSASGVHLAMEASLRTRVRDTFRVTMAVAPESVKRRLAAASRTSTTSTSSMTAVTTAGAAATMQSRVRVNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0JX39</accession>
    <name>R0JX39_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_164121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027870.1">
        <property type="nucleotide sequence ID" value="XM_008029679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JX39"/>
    <dbReference type="STRING" id="671987.R0JX39"/>
    <dbReference type="GeneID" id="19399003"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA85503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="310" mass="34043" checksum="DE618CB3D71FAA4F" modified="2013-06-26" version="1">MAPSAVQVEPRQLPQTKQLVPRSKEDASKELTPLQAISQGMCLPSVPLFSSYDKQRAWILSHMAGAFRIFARNGFTEGMSGHISVRDPENPHTFWTNPLGKHFGLIKASDMVLVDYEGKVVGGNQSRPANAAGFLIHSAVHKARPDVNAACHCHGRAGKAWSAFARPLEMLNQDACYFYGDAQAVYKDFGGVVFSEEEGKRLAAALGPKGKAMVLRNHGLLTVGSTVDEAAYLYTLMERSCQVQLQVEAAAANGIPKVYVDDDAASYTFEMGSDAETLYWELQPDLEYEYEMSNGNFAHPDCDEVVWPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXI1</accession>
    <name>R0JXI1_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_122427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA82179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030467.1">
        <property type="nucleotide sequence ID" value="XM_008032276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXI1"/>
    <dbReference type="STRING" id="671987.R0JXI1"/>
    <dbReference type="GeneID" id="19395881"/>
    <dbReference type="eggNOG" id="ENOG502S8HR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108991_1_0_1"/>
    <dbReference type="OrthoDB" id="514292at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009187">
        <property type="term" value="P:cyclic nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA82179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20895" checksum="900D0C496456554E" modified="2013-06-26" version="1">MPGSSLWLLPPADHPLNKVLPGLIDQTSKSFGSPHRFLPHVTLTSEISPSKYGSDGPAWLSALDLGPAKDVRVNLERLGSDDFFFRKLYIKCEKDGGLKTLAKQCRKHVDGYADEKTAQDWAKEAYMPHVSLMYHDCPQVDEKELVAVDTLEVKLGGTGDMSGWVGGRVVLVPTDKPIDQWVPIAERVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXK7</accession>
    <name>R0JXK7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_35884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031257.1">
        <property type="nucleotide sequence ID" value="XM_008033066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JXK7"/>
    <dbReference type="STRING" id="671987.R0JXK7"/>
    <dbReference type="GeneID" id="19404063"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_1_1_1"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA80997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="209" mass="20515" checksum="C9E8A622722C732D" modified="2013-06-26" version="1">MSGAANRQGKMQNLINYRMKVTLQDGRQMVGQMLAFDKHMNLVLADTEEFRRTRRKGKAAPGATQQVTETEERRAIGLTIIRGAHVISLSVDGPPPADPAARLGANSGPSTAAALAAGPGVARPAGRGLPVGLTGPAPGVGAPGPGFGGGFPGAPGGFAPPGFPGRGGPPGGPPGFPPAGGPPGFGGPPGFGGPPGFPGRGGPPGFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0JXW3</accession>
    <name>R0JXW3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_24591</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA81082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008031207.1">
        <property type="nucleotide sequence ID" value="XM_008033016.1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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            <strain evidence="5">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>R0JY78</accession>
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            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908626">
        <property type="protein sequence ID" value="EOA85873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026460.1">
        <property type="nucleotide sequence ID" value="XM_008028269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JY78"/>
    <dbReference type="STRING" id="671987.R0JY78"/>
    <dbReference type="GeneID" id="19400916"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_7_2_1"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="33"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="622"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA85873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="709" mass="79665" checksum="74E7B24903A365FD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>R0JYG4</accession>
    <name>R0JYG4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_95599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029628.1">
        <property type="nucleotide sequence ID" value="XM_008031437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JYG4"/>
    <dbReference type="STRING" id="671987.R0JYG4"/>
    <dbReference type="GeneID" id="19406176"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_12_1_1"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA82514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="161" mass="17418" checksum="B534F841897946D0" modified="2013-06-26" version="1">MSALKFVRSVWESFRANSGLEPRLLDGLRVTSAVPGRVKFELDIQKEHTNRLNILHGGTIASMVDLGGSLAVASRGLFATGVSTDLNVTYLSSGGKIGDLVKAEVSCDKFGKTLAYTSISFSNSKGEIFARGSHTKYVALAWKDPNNIVEELSPKPDEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>R0JZ46</accession>
    <name>R0JZ46_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="15">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SETTUDRAFT_47519</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Proline-directed serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="15"/>
    <dbReference type="EMBL" id="KB908604">
        <property type="protein sequence ID" value="EOA86138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026125.1">
        <property type="nucleotide sequence ID" value="XM_008027934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0JZ46"/>
    <dbReference type="STRING" id="671987.R0JZ46"/>
    <dbReference type="GeneID" id="19405138"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EOA86138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="356" mass="40812" checksum="F4F3344CD771A5EC" modified="2013-06-26" version="1">MAEFVRAQIFGTTFEITSRYTDLQPVGMGAFGLVCSAKDQLTNQAVAVKKIMKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTICSENTLRFVQSLPKRERQPLANKFKNAEPEAVDLLENMLVFDPRKRVRAEQALAHPYLAPYHDPTDEPIAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVDAAAQDAPESNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K0V4</accession>
    <name>R0K0V4_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SETTUDRAFT_31074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025019.1">
        <property type="nucleotide sequence ID" value="XM_008026828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K0V4"/>
    <dbReference type="STRING" id="671987.R0K0V4"/>
    <dbReference type="GeneID" id="19403502"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_0_1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EOA86753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="383" mass="41292" checksum="8A1CDD074BA366F4" modified="2013-06-26" version="1">MADQCSYKDNGNFVNATCTQGGYAEYAVKVSDVAQMQLAVNLARNLNLGLVVRNTGHDYNGRSVGKGALSIWTHGLKEIKYVEKYISPTYEGPVFKLGAGVQGFELYQAADKLGVSAVAGICPTVGVTGGYSTGGGHLPLMQLFGVGADRIVALEVVLARGRFATATPEVNSHLYWAMLGGGGGTFGVIASAMAKTHRRVPVTTSSWSIMTSETVTADKLWEAFRFYLDKMPSYFTLMALAPGAYLWTMNPIFATGKTVEEYETLIKPFYDKCHVCDVQLLHWRGGEGMACNRPVTWDNWKGSASRDQTFAAMRRVVESAGVVNMHHQRPAAQKSKHGNSAKPAVGDEESQVVIINSVGEQAAAGGAYGNEADIAEPAWQHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>R0K1X7</accession>
    <name>R0K1X7_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">SETTUDRAFT_41555</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA87123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025134.1">
        <property type="nucleotide sequence ID" value="XM_008026943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K1X7"/>
    <dbReference type="STRING" id="671987.R0K1X7"/>
    <dbReference type="GeneID" id="19404711"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="81"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="292"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="467"/>
            <end position="470"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="485"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="502"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="630"/>
            <end position="631"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="636"/>
            <end position="640"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EOA87123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    </reference>
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    <sequence length="345" mass="40325" checksum="B9C70A3209AB05BC" modified="2013-06-26" version="1">MATKAPRRHIIPREPLCPSLPAEIWINIFTYCTDLAHLWNTVRRVSSVLRACVDRAFAHHFLHDMHIDFALEKYNLGGRSKRPELRTRFSRRSICADADDDDDDDDGDDVELAWFKDERPDPPQRSNEQYNTVTQRWIEHVESWKPEMPRYTITLGSMVNDTPLVNLSVCAATREISFEWRASLELFFREQARLEVLRRRFDDQMKVKMDEVEERVKRGEKLVPGDYPDKWESVENAFRRGVRRKRLKGWYEGDEEMLWAIESLACFEQGGGSGHADGERAASAVSTRGSHHHQISRDFRLNPDLPGARLGEKWFGSVYLVQELYLDEWSCMHRIDMKEDQIGAK</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">28A</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <strain evidence="2">28A</strain>
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    <evidence type="ECO:0000313" key="2">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027455.1">
        <property type="nucleotide sequence ID" value="XM_008029264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K611"/>
    <dbReference type="STRING" id="671987.R0K611"/>
    <dbReference type="GeneID" id="19396400"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_0_1"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000060">
        <property type="entry name" value="Mitochondrial carnitine carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="235"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA84949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="34109" checksum="6023CB1B3827DBFC" modified="2013-06-26" version="1">MASTADAAIEKLPSTADLKEDAKAATKSTVQSLRALVAGGVGGVCAVVVGHPFDLVKVRMQTAEKGVYSGAMDVVRKTIAKEGLARGLYAGVSAPLVGVTPMFAVSFWGYDLGKQLVSSVSKVENNQYSVAQVSAAGFFSAIPMTVITAPFERVKVLLQIQGQKQLAPGEKPKYSGGLDVVRQLYKEGGIRSVYRGSAMTLARDGPGSALYFATYEVIKRNLTPKDPVTGQPGSLSIGAVMVAGGAAGVAMWIPVFPVDTIKSRLQSAEGRPTIGGTIRGLYASGGIKAFFPGIGPAMARAVPANAATFAGVELAQKAMTKMFDRDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6E2</accession>
    <name>R0K6E2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SETTUDRAFT_163810</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027565.1">
        <property type="nucleotide sequence ID" value="XM_008029374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6E2"/>
    <dbReference type="STRING" id="671987.R0K6E2"/>
    <dbReference type="GeneID" id="19398903"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="392"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EOA85084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="449" mass="49845" checksum="FA31F421AA282615" modified="2013-06-26" version="1">MADPVAILDEIAAIEKRIEEAQAQLKDARERLRKAQDAMYVGPGANMSEEEKMALIKVNLAEVLNPEIMDEAMKKQGHLKVYWGTATTGRPHCGYFVPILKLAQFLAAGCHVKILLADIHGFLDNLKAPIELVKYRAEYYRFTITTLLKAVKVPIEKLEFVLGSSYELNADYAMDLLRLASITSEATAKKAGAEVVKQTENAPLSGLIYPLMQALDEQYLDVDVQFGGVDQRKIFALAKDVLPKIGYKERAHLMNPMVPGLQGGKMSASDPDSKIDVLDDADVVKRKLKKAHAAPKVVEENGVLSFVEYVLLPAGHLIYGEPKFVVKRRDAEPLVYTEISKMHDDYRSDILTPQDLKPAVTEALITLLEPVQKEFQANPQWKEIEQKAYPPPPVVKKEKKVKNKGTFHPKRNVEAKPDGHVEGADKATVDVGTEGGEKAIEGLSLEEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6G3</accession>
    <name>R0K6G3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_129550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023972.1">
        <property type="nucleotide sequence ID" value="XM_008025781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6G3"/>
    <dbReference type="STRING" id="671987.R0K6G3"/>
    <dbReference type="GeneID" id="19396081"/>
    <dbReference type="eggNOG" id="ENOG502QSR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_0_1_1"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA88588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="231" mass="25720" checksum="A3EECD6B1FE8106B" modified="2013-06-26" version="1">MTNNSQPPLPVPQVPIREADKQLFASINSFVYEYMSKYDNSHDYQHILRVLSNTNRILQAELKANPSVAYDTTPLFLAALLHDVGDHKYAKPGEDAENQIANTLLQHSASSELATKVQAIVKNLSYSHEVRDPARVASAMAQHPELAIVQDADRLDAIGAVGIARCFSFGAAKMPEQPMDRAISHFEEKLYNLAGMMKTAAGKDMASRRHKVLEEFAKEWKGETELSLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>R0K6X3</accession>
    <name>R0K6X3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Plasma membrane iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_32509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027039.1">
        <property type="nucleotide sequence ID" value="XM_008028848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0K6X3"/>
    <dbReference type="STRING" id="671987.R0K6X3"/>
    <dbReference type="GeneID" id="19403661"/>
    <dbReference type="eggNOG" id="ENOG502QQWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046738_0_1_1"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061840">
        <property type="term" value="F:high-affinity ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EOA85294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38773" checksum="C8419397BAA05699" modified="2013-06-26" version="1">MPNVFAVPVFFICFRECLETSIIVSVLLAFLKQTLGPSQDAAVYKRLVRQVWYGVGAGVIICLIICAGVIATFYTAGKNTFETAENIWEGVFGILASVIITLMGAALLRISKLQDKWRVKISKVLEQKDLNLPVKGKLKRWTEKYAMFILPFITVLREGIEAVLFIAGVSLSAPATSFPLAVICGLGAGALVGFFIYKGGNKTSLQIFLVVSTCFLYLVAAGLFSKGVWNLEQNAWVKLAGEGAAEAGSGPGSYDIRNSVWHVNCCSPLENGSGGWGIFNSLLGWQNSATYGSVISYNVYWLAVILGFVFMGLRERKGSASHNGEMESDTSSEQRETAQASKIADEGMGVNTAVREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>R0K8Z5</accession>
    <name>R0K8Z5_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_39941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EOA89713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="671987.R0K9Q5"/>
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    <dbReference type="eggNOG" id="ENOG502SWMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA89713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="151" mass="16804" checksum="862618F4AF62255A" modified="2013-06-26" version="1">MSPNTDPYTRTLIVALKSPSVGKSISQISELTGVHPRTVNRIYSRAIEAGFEPNVLPLKILPEHVQDAPRSGRPSKQTDKVKEQIIQQVRRDRYGREKSCADVAGALSLQGVNISRTTVWRVLREAGYRKTKPTRKPGLTQEMRSARLSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAW8</accession>
    <name>R0KAW8_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SETTUDRAFT_145590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022012.1">
        <property type="nucleotide sequence ID" value="XM_008023821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAW8"/>
    <dbReference type="GeneID" id="19396819"/>
    <dbReference type="eggNOG" id="KOG2886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094297_2_0_1"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="199" mass="21443" checksum="16B76B81FDF306F9" modified="2013-06-26" version="1">MSSLATFKNPSTYHLLSYGTLLGSTLFQSFVSGVIAFRVLPRPQFSTLQKHTFPIFFGLQTVAPIAMFLTYPRGATSLIPSFLLPSSPAAPPPSFSFFAPASTSTSNNKLASWLHAAMLATAVVNLVYIGPKTTEVMGIRKHQETRDGKKSYDSGPHSKEMQALNKQFAILHGVSTLINLAGLGAMIWYGGVLAEGLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>R0KAX3</accession>
    <name>R0KAX3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Shwachman-Bodian-diamond syndrome protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SETTUDRAFT_138049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA85402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027804.1">
        <property type="nucleotide sequence ID" value="XM_008029613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KAX3"/>
    <dbReference type="STRING" id="671987.R0KAX3"/>
    <dbReference type="GeneID" id="19396444"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_0_1"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990932">
        <property type="term" value="F:5.8S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="109"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="235"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA85402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32698" checksum="51FF4FDBE8802964" modified="2013-06-26" version="1">MVINQPSNQIKLTNVSLVRMKKGKKRFEIACYKNKVLEWRNKVEKDLSNVLQIENVFLNVSKGQAAPKADLEKAFPKKSLMEIITDILDHGELQVGEKERNAELERTKNEVIDIVAGKLVDPRTKRVYTTGMIEKALDQLSSAAASQQADKDKAEAKDEGDDKAKAKELPKWTGIVTNKSAKSQALFAMKALIAHQPIPVARMQMKLRVTCATSVLKQGIKTAPKAQAGADDKGATGTVKDAILGFMENIESQETIGAEWEAVGLVEPGAFKGLNELIESQTKGRGNVEVLEMAVGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>R0KB55</accession>
    <name>R0KB55_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SETTUDRAFT_153415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025259.1">
        <property type="nucleotide sequence ID" value="XM_008027068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KB55"/>
    <dbReference type="STRING" id="671987.R0KB55"/>
    <dbReference type="GeneID" id="19397296"/>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013931_1_1_1"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004354101" description="Tyrosine specific protein phosphatases domain-containing protein" evidence="8">
        <location>
            <begin position="31"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="659"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA86609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="742" mass="80905" checksum="5EC882F58E7A0572" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>R0KBR6</accession>
    <name>R0KBR6_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_89557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025422.1">
        <property type="nucleotide sequence ID" value="XM_008027231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0KBR6"/>
    <dbReference type="STRING" id="671987.R0KBR6"/>
    <dbReference type="GeneID" id="19405783"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908592">
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        <property type="entry name" value="DUF3425"/>
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        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="362" mass="40812" checksum="FB262E3239A0C239" modified="2013-06-26" version="1">MPDAAAAQRSWLYPGDAPTSHLRRYSSDSPGPHFGQARTPHMHSDMPFDERLGVDFLLDNGQRRPVDPNLPPPHHARPSNVSTSQHAQYAPSLVAHLTLPRNLPATCPLDVILLDFLQDRQNRAAEGVPIKTLVGPHYPNFTSLAYPDRAVESHPLSKLFTDILRTFPDICGRPEQVAIVFIMFLIMRWQIEPTQENYDRLPHWVTPRPAQLFTPHALWIDHLPWPRLRERLITAQPPVSFENFFIPFTTTVSLNWPYEHRDCLLPASIVRHTTLSTTSSSIAASSPFSTHVNAGSPQGPATPQPPTGNIPTMDQLPKEDDQWLINPAFETHLRDLNNWSLGPSFRGTFPMFADAVKIKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0KD33</accession>
    <name>R0KD33_EXST2</name>
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    </gene>
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
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            <end position="200"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="200" mass="21983" checksum="B8D98EB8B5982D79" modified="2013-06-26" version="1">MTRSRVNIRPAVFPDDKDTVGRLFLAYAQSLPVSLDFQNFEHELAALPGKYAVEKGGAVWLAYASPKASEPAPAPNGNAHSDAKPVEDEQAVGCIAIRPFFTTPTTAESSALLASSTSPATTTCELKRLFITPESRGLGVSKLLMDVAVSEARELGYKEVLLDTLRTMTPARRLYEKFGFEETRSYYENPNDAVFYRLVL</sequence>
</entry>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">SETTUDRAFT_110184</name>
    </gene>
    <organism evidence="4 5">
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908604">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="121"/>
            <end position="155"/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Steffenson B.J."/>
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                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EOA87727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008026425.1"/>
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    <dbReference type="AlphaFoldDB" id="R0KI69"/>
    <dbReference type="STRING" id="671987.R0KI69"/>
    <dbReference type="GeneID" id="19400700"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:translation elongation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_V-like"/>
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        <property type="entry name" value="EFTu-like_2"/>
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        <property type="entry name" value="G_TR_CS"/>
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    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
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        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELONGATNFCT"/>
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        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA87727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="843" mass="93725" checksum="8BEBB990F5757994" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0KIC0</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_38281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908526">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="188" mass="21090" checksum="5A825DD31D447262" modified="2013-06-26" version="1">MIASSFTTDLFLALIVLASTILAVILVYLALRFVHRRKKKACAQQDFEPGLLDVESGRESRLSHRLSRQQIQQEQREDLLQHYSSVPRPPSIELLPEIKTSSSDSRAVEWLEQGVAHEGVDVVDGDLGEKKPDIRHVAVAKPKKQLRWECRAENMVHHDTSPGVIEKTENDGVKCVEHGTEKPNGISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0KIY9</accession>
    <name>R0KIY9_EXST2</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_27927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EOA89292.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="123" mass="14057" checksum="C0B400680D91F92C" modified="2013-06-26" version="1">MEYLFYSICFIVLAVATAAYFTRHRWIHLLPIPEPIYSRLPTSFRDDIEAGLSSSAFDLSGNVEAGDSRQGLDDAGKKEVMRIMKRQGVDFDEARRIYMQDRFKKNNIGADGIPRDPKFVSFS</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
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    <dbReference type="EMBL" id="KB908482">
        <property type="protein sequence ID" value="EOA90609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_008023220.1"/>
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    <dbReference type="GeneID" id="19399856"/>
    <dbReference type="eggNOG" id="ENOG502SR07">
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    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="18"/>
            <end position="190"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EOA90609.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20491" checksum="A53FF73F2BB45CA0" modified="2013-06-26" version="1">MALDRLLALVACLPCGAHHHRQPDATPPCDEKASLLSHDVAVATANDVVATLLTTSSSGPALRMELDSKVGAYGWRQHLAELILDKLAQVLQTAHEKLGPSVNSAYQRAVSAVAEIEGFVIEHPVISTVVALGVLALLAPWVLDALGFADLGPAAGSFASWWQARYAGYVPKRSLFSFFQRLGMKWHWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>R0KPA7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">SETTUDRAFT_167502</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_2499282_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA89677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="86" mass="9525" checksum="5A3376D2A43A6558" modified="2013-06-26" version="1">MANRNGRTPIITTAPHIYTHPSTPSAVGSEKQSDSSWHRQESARPRCAITPFPPVHMHMDMHPRPTPCALAHGPVQTHSPGWHPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>R0KSJ8</accession>
    <name>R0KSJ8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_166670</name>
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    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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</entry>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Glaser F."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">28A</strain>
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    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">28A</strain>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="common">Northern leaf blight fungus</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908877">
        <property type="protein sequence ID" value="EOA80951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2211608_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA80951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="107" mass="11335" checksum="C14DA60DB21923D7" modified="2013-06-26" version="1">MHPTTAPDRRSSEAEPSALLAAVSLCAAAAAAALGLLSSSPPSPGRRRRGAYAGLRLAPGPRHACCTMPSDHFRRSARFTLHTSAHTSHTHTHTHSNARCTRRASTM</sequence>
</entry>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
        <property type="protein sequence ID" value="EOA81381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="R0I7D4"/>
    <dbReference type="STRING" id="671987.R0I7D4"/>
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        <property type="evidence" value="ECO:0007669"/>
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            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA81381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="111" mass="12425" checksum="2A5427A0CE9B4C40" modified="2013-06-26" version="1" fragment="single">NSGSNLFVTGIHPTLTEDEVTRLFEKYGDVEQCNIMRDPHTKESRGFGFVKMVTSEQADAAKEGLQGEVHQGRTLSIEKARRARPRTPTPGKYYGPPKRGKCGWCLFGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>R0I872</accession>
    <name>R0I872_EXST2</name>
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            <fullName evidence="4">Glycosyltransferase family 1 protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908866">
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    <dbReference type="AlphaFoldDB" id="R0I872"/>
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    <dbReference type="STRING" id="671987.R0I872"/>
    <dbReference type="GeneID" id="19406398"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000537_1_2_1"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GT1_Gtf-like"/>
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    </dbReference>
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        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
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    </dbReference>
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    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
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                <person name="Henrissat B."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908855">
        <property type="protein sequence ID" value="EOA81821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008030213.1">
        <property type="nucleotide sequence ID" value="XM_008032022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0I8U4"/>
    <dbReference type="STRING" id="671987.R0I8U4"/>
    <dbReference type="GeneID" id="19397666"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EOA81821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57027" checksum="FA9F1BCEC284A77C" modified="2013-06-26" version="1">MTVPSSSSNADVRSGPSLDSVKQAIPIITTVSLAIVALISFLVISHQSKLPVVNGPGWFELTTFKRLNFMKNGADILRDARKRYHSQPYNLVMSAGLITMLPPKYAQIIRNDPRLSFGHSFARDFAGDVHGLEPLNTLADQRRLVQLVIQKQLTKHLNWREIRITDSILQLVARLSTKVFLGDKLCRNESWLQASKEYTLYSFRAALSVIFLPSPLKYLMSFFSNDVRLAKQSLTKSRNVLEPIIQERRKARTEAIKNGEPAPAYNDMLDWLDQESKGGSYDPVHYQMVLSAGAIHTTSDLLGQTIMRLAQEPGWIAELRKEIIEVLSKDGLTKAALANLKLMDSALKEASRLIPISGMLMRRLAKEDITLPEGIVIKKGQFLAVDGIEAWKAKNYPEPLKFDMYRFYRLRQDPSTASKAHLVSTSPEHLGFGHGDQACPGRFFAANEMKIALCHLFLKYDWELTPGANLEPYHVYGDVFTLDPNNVIRFRRRKEEVDLEGLAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>R0IA80</accession>
    <name>R0IA80_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_95973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008029541.1">
        <property type="nucleotide sequence ID" value="XM_008031350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IA80"/>
    <dbReference type="STRING" id="671987.R0IA80"/>
    <dbReference type="GeneID" id="19406198"/>
    <dbReference type="eggNOG" id="ENOG502RYEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018542_0_0_1"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="114"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="434" mass="47122" checksum="5D18F8F28AC2579E" modified="2013-06-26" version="1">MDASPAPPASPAPPKSPAANATSPLLPLPNDARPALEETRRPSTIQFLAHRNASLPRGTPRPRERRRLSSPPPPPVFQNRVSFDTFDKPADFIEESSFTLIAKHKDYEYTKRSRTFLCGFDENEYSVYALQWLINELVDDGDEIVCLRVVEKEDAIAGDRSVESGRYRVEAENAMSDIQSRNHDNKAINLILEFSIGKVNKVIDDMINLYEPAILVVGTRGKSLGGFQGLLPGSVSKYCLQHSPVPVIVVRPTSKRDKAKSKRTNDPDRQGYRELLAKSERLPDYDSPRNRFFANEDEAAAVARAIAAPKPAVETIHPLAQVERAQDSSGDELETGDSSTMVGDDPRSPGPMMKSPHLQNLDSPELSSQSSSDDEDEQAGVSSSTESRGADAAAQEAAQADAAKDVSKDATQDATQDAARDAAAAAASKGAQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>R0IBI4</accession>
    <name>R0IBI4_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SETTUDRAFT_95466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908844">
        <property type="protein sequence ID" value="EOA82606.1"/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">28A</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SU96">
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        <location>
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            <end position="46"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA82786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
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    </evidence>
    <sequence length="118" mass="13173" checksum="179502DD28312C7E" modified="2013-06-26" version="1">MGFLSILPESLKALETWITRIFLFLGLLAIGPWVALLIYDILLYLFRACVHEIPVVGGRAQGKDRPRAPSLTERPSGRRRKFSLRGFDRPVLSTGGANVDARDARHRRITEVTVGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908833">
        <property type="protein sequence ID" value="EOA83066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028903.1">
        <property type="nucleotide sequence ID" value="XM_008030712.1"/>
    </dbReference>
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    <dbReference type="STRING" id="671987.R0ID22"/>
    <dbReference type="GeneID" id="19397544"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
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    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
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    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
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    <dbReference type="InterPro" id="IPR036396">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
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    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA83066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57592" checksum="E735ABA1AFD36AF4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>R0IF65</accession>
    <name>R0IF65_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="2 3">
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        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">28A</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_008030029.1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004353015" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EOA83706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9246" checksum="625E30564965E488" modified="2013-06-26" version="1" fragment="single">MPFRQSLIFCLLLHTSPLLALPCTLWSRSPHDLVSCQGPPSPPLSLARCHCFAVTLDLRNTTCIATSQGACMERIHIRVIPGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>R0IG65</accession>
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        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">SETTUDRAFT_164447</name>
    </gene>
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        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:protein phosphatase type 2A complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:establishment of protein localization to chromosome"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of autophagosome assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:sister chromatid biorientation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
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    </dbReference>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="610"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="654"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EOA84220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="720" mass="80345" checksum="FEB677F5282656F7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>R0IGQ2</accession>
    <name>R0IGQ2_EXST2</name>
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        <recommendedName>
            <fullName evidence="3">DUF4048 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SETTUDRAFT_42850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908814">
        <property type="protein sequence ID" value="EOA84166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008028167.1">
        <property type="nucleotide sequence ID" value="XM_008029976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IGQ2"/>
    <dbReference type="STRING" id="671987.R0IGQ2"/>
    <dbReference type="GeneID" id="19404798"/>
    <dbReference type="eggNOG" id="ENOG502S19N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016967_3_1_1"/>
    <dbReference type="OrthoDB" id="4097086at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025122">
        <property type="entry name" value="DUF4048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13257">
        <property type="entry name" value="DUF4048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4048" evidence="3">
        <location>
            <begin position="169"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EOA84166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="481" mass="53097" checksum="E07DB3F465BC1DA1" modified="2013-06-26" version="1">MSAHTRSKTIDVVGQGKRLSLQFPIQPSPATIYTPASAKRTRPQSWVHGATPIRSPEPPDDTPHETNILAVLAAQERYVLELKEELTKAEADLTMLKSHWARHEANKRRTQGRKVAALQPLDTSLANAPPSPYDDDSSGLSMQKEMERRKTLLNHAKTSQRKVFSGSRHLRTLSLLSPERIDSPAFSQTVDLLDDRSPAMRSQSSARTSTSSDITRQVVTAGDHDRYEMGGMPTIQREQLIRAGTQMATDFKKGLFTFIEDIRQATVGDEALHMGDSAAGMAGTKGASKSGRKPSDGRPPLSRSASSKKSQQTGSFGDDFWKEMGVTDPKTSTTHKKTQPTKSTATPQKQIRKVASEEDWDNWDTPNDSLLVDVTDSKDSSDDSDAHTSPMSGPGSSSTSTSTRYHAKRHDSKASSLTSITQEDLAPREPKRSSITWPDMTKVSPSNLKRTASHLMKEWEKQLTPPPESRTQDYSHGDYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>R0IHS9</accession>
    <name>R0IHS9_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SETTUDRAFT_163576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">28A</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027291.1">
        <property type="nucleotide sequence ID" value="XM_008029100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IHS9"/>
    <dbReference type="STRING" id="671987.R0IHS9"/>
    <dbReference type="GeneID" id="19398806"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EOA84735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="147" mass="16512" checksum="3DF4E7DA9536D95C" modified="2013-06-26" version="1">MALKRINKELTDLGRDPPSSCSAGPIGDDLFHWQATIMGPGDSPYSGGVFFLAIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRSRYESTAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>R0IIZ2</accession>
    <name>R0IIZ2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase 14</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Deubiquitinating enzyme 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin thioesterase 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-specific-processing protease 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SETTUDRAFT_91696</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">28A</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="KB908703">
        <property type="protein sequence ID" value="EOA84916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008027430.1">
        <property type="nucleotide sequence ID" value="XM_008029239.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IIZ2"/>
    <dbReference type="GeneID" id="19405926"/>
    <dbReference type="eggNOG" id="KOG0944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001397_0_0_1"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000235">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000144">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="22">
        <location>
            <begin position="1275"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="21">
        <location>
            <begin position="1426"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="20">
        <location>
            <begin position="1722"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="20">
        <location>
            <begin position="1788"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="734"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="737"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EOA84916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1927" mass="213902" checksum="BCCA9CE71973B09C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>R0IKD7</accession>
    <name>R0IKD7_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_40206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908670">
        <property type="protein sequence ID" value="EOA85565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008026768.1">
        <property type="nucleotide sequence ID" value="XM_008028577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IKD7"/>
    <dbReference type="STRING" id="671987.R0IKD7"/>
    <dbReference type="GeneID" id="19404590"/>
    <dbReference type="HOGENOM" id="CLU_1152362_0_0_1"/>
    <dbReference type="OrthoDB" id="10419710at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA85565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="241" mass="28025" checksum="4019EDFDF85E07A2" modified="2013-06-26" version="1">MPTNTSQAGGVMIASNRNGSIRVSITGTCESGTVDEAVLEWVKDQNRYCFDMTCKATLSYFVSCPKAMLSSIKHVTLTRTMMSSDDYNNYAYAEDLARKLQQEVVLESITLAVPHDNELLDIKSDEFEWWMWTLHQGAIDGFKEGRIAMVRFLFRTLYTTVKDVKKFRAYGEIQLRVVGQKYEDWLDSCIRARDEEGFDDSIMRETPKEHLDSMWEQLEYIIEIDERREEEEGTVLILRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>R0ING2</accession>
    <name>R0ING2_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_178590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008025193.1">
        <property type="nucleotide sequence ID" value="XM_008027002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ING2"/>
    <dbReference type="STRING" id="671987.R0ING2"/>
    <dbReference type="GeneID" id="19401622"/>
    <dbReference type="eggNOG" id="KOG1993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003886_1_0_1"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
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    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA86515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117867" checksum="503A9A12B6BB7B1C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPR0</accession>
    <name>R0IPR0_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SETTUDRAFT_19439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">28A</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="KB908592">
        <property type="protein sequence ID" value="EOA86925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024913.1">
        <property type="nucleotide sequence ID" value="XM_008026722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0IPR0"/>
    <dbReference type="STRING" id="671987.R0IPR0"/>
    <dbReference type="GeneID" id="19402200"/>
    <dbReference type="eggNOG" id="KOG3730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015023_0_0_1"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="201"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="827"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="840"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EOA86925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="873" mass="96724" checksum="73E66C674899D27C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>R0IPX3</accession>
    <name>R0IPX3_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SETTUDRAFT_87990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
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                <person name="Henrissat B."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Xue C."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">28A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KB908548">
        <property type="protein sequence ID" value="EOA88250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008024282.1">
        <property type="nucleotide sequence ID" value="XM_008026091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0ITY1"/>
    <dbReference type="STRING" id="671987.R0ITY1"/>
    <dbReference type="GeneID" id="19395284"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_2_0_1"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="371"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EOA88250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="492" mass="52937" checksum="E255BAD67D7F5B44" modified="2013-06-26" version="1">MDPNPSQAPILDTLDKTAGHGFALPVKRIHDGDDVTAFLASRAYADIMTFIFQLNTAMIPRAVETKEQGEEAAPAKEWQLNDKDVAYPSVVHSLAKLLDTLTAIIDEAPPDPGPRRFGNISFRTWYDIVRERVPGLLYEHLPQQVLDFKSTSDISAKSELEAYLLGSFGSSQRLDYGTGHELSFLAFLGCLWKLGAFPESQDGDQERAIVLGVLEPYLALIRRLILTYTLEPAGSHGVWGLDDHSFLPYIFGSAQFSPAITTPADVAAEGSLPTAPHPGDVAKAPAVARERTRNMYFSAIGFIYDVKKGPFWEHSNILYDVSGVKAGWAKINKGMIKMYNAEVLSKYPVVQHFPFGSLFSFSPDPNAKKIQATVHTASQPKASSTPSNTAPTARPQPPLRDPLADPSSSATMATRPPGGAVGTAAPWARGATGPGVPSGVNQPTRAPWASRTPAPPPPSTTMAGVGTAAPWAKKDAGGDAQQSTRAPWANKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVQ8</accession>
    <name>R0IVQ8_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SETTUDRAFT_38706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908537">
        <property type="protein sequence ID" value="EOA88671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008023763.1">
        <property type="nucleotide sequence ID" value="XM_008025572.1"/>
    </dbReference>
    <dbReference type="STRING" id="671987.R0IVQ8"/>
    <dbReference type="GeneID" id="19404381"/>
    <dbReference type="HOGENOM" id="CLU_250474_0_0_1"/>
    <dbReference type="OrthoDB" id="3693101at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
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        <location>
            <begin position="872"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
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        </location>
    </feature>
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        <location>
            <begin position="970"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EOA88671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="1466" mass="161022" checksum="B9206F5EB08C0BB6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>R0IVT5</accession>
    <name>R0IVT5_EXST2</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SETTUDRAFT_167985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Martin J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EOA90090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13886" checksum="AF3E9DF0508E836C" modified="2013-06-26" version="1">MDPDAPVANEPQPSVFRWVLGFLIVGACWGLTTPFMRKAAINYTPPQRPALTDPDNSWLKKKVLGVLYAVIGVLSRPAYAIPLLLNVTGSVWFFILIGKAELSLTVPITNSLAFMFTVLGEWWIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0J186</accession>
    <name>R0J186_EXST2</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SETTUDRAFT_102841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exserohilum turcicum (strain 28A)</name>
        <name type="common">Northern leaf blight fungus</name>
        <name type="synonym">Setosphaeria turcica</name>
        <dbReference type="NCBI Taxonomy" id="671987"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Exserohilum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">28A</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB908493">
        <property type="protein sequence ID" value="EOA90536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_008022354.1">
        <property type="nucleotide sequence ID" value="XM_008024163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R0J186"/>
    <dbReference type="GeneID" id="19394948"/>
    <dbReference type="HOGENOM" id="CLU_1455123_0_0_1"/>
    <dbReference type="OrthoDB" id="3677053at2759"/>
    <dbReference type="Proteomes" id="UP000016935">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EOA90536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016935"/>
        </source>
    </evidence>
    <sequence length="221" mass="25139" checksum="50080624EE934298" modified="2013-06-26" version="1">MTAAAIDPLVPIVFDATKAEEVMDEIVEAIGTDTTKLRMTIEVIYHRAMQSEHWADMAVKLLAMLSERIPQTLSDPDIALDKNGVAFVGPRLVRRYLFTRIQSDFDADIQKPSWSVPLVHFLYGLSRTMTQSLRMSYRVQTQIISKMAKSDHLFVETNMELFLLFVSWLGPNLDKEQDKDAILTDVLLGVRERADLESTLMRLAVVGLVRLREDGWPSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>R0J1H8</accession>
    <name>